diff --git a/.gitmodules b/.gitmodules
index 7bb49e98bfec1..f874660971d41 100644
--- a/.gitmodules
+++ b/.gitmodules
@@ -7,4 +7,4 @@
 [submodule "cmake/external/emsdk"]
 	path = cmake/external/emsdk
 	url = https://github.com/emscripten-core/emsdk.git
-	branch = 3.1.44
+	branch = 3.1.51
diff --git a/cgmanifests/generated/cgmanifest.json b/cgmanifests/generated/cgmanifest.json
index 137ea8a50c011..bcd0b2a92a5c3 100644
--- a/cgmanifests/generated/cgmanifest.json
+++ b/cgmanifests/generated/cgmanifest.json
@@ -6,7 +6,7 @@
       "component": {
         "type": "git",
         "git": {
-          "commitHash": "a896e3d066448b3530dbcaa48869fafefd738f57",
+          "commitHash": "4e2496141eda15040c44e9bbf237a1326368e34c",
           "repositoryUrl": "https://github.com/emscripten-core/emsdk.git"
         },
         "comments": "git submodule at cmake/external/emsdk"
diff --git a/cmake/adjust_global_compile_flags.cmake b/cmake/adjust_global_compile_flags.cmake
index e825bfeaea952..596f20d69b9bf 100644
--- a/cmake/adjust_global_compile_flags.cmake
+++ b/cmake/adjust_global_compile_flags.cmake
@@ -16,9 +16,7 @@ if (NOT MSVC AND NOT onnxruntime_ENABLE_BITCODE)
 endif()
 
 if (CMAKE_SYSTEM_NAME STREQUAL "Emscripten")
-  string(APPEND CMAKE_C_FLAGS " -s STRICT=1 -s DEFAULT_TO_CXX=1")
-  string(APPEND CMAKE_CXX_FLAGS " -s STRICT=1 -s DEFAULT_TO_CXX=1")
-  set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -s ALLOW_UNIMPLEMENTED_SYSCALLS=1")
+  set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -s ALLOW_UNIMPLEMENTED_SYSCALLS=1 -s DEFAULT_TO_CXX=1")
 
   # Enable LTO for release single-thread build
   if (NOT CMAKE_BUILD_TYPE STREQUAL "Debug")
diff --git a/cmake/external/emsdk b/cmake/external/emsdk
index a896e3d066448..4e2496141eda1 160000
--- a/cmake/external/emsdk
+++ b/cmake/external/emsdk
@@ -1 +1 @@
-Subproject commit a896e3d066448b3530dbcaa48869fafefd738f57
+Subproject commit 4e2496141eda15040c44e9bbf237a1326368e34c
diff --git a/cmake/onnxruntime_unittests.cmake b/cmake/onnxruntime_unittests.cmake
index 7c8c70f913dca..0c1fee7bb4410 100644
--- a/cmake/onnxruntime_unittests.cmake
+++ b/cmake/onnxruntime_unittests.cmake
@@ -906,7 +906,7 @@ if (onnxruntime_ENABLE_TRAINING_TORCH_INTEROP)
 endif()
 if (CMAKE_SYSTEM_NAME STREQUAL "Emscripten")
   set_target_properties(onnxruntime_test_all PROPERTIES LINK_DEPENDS ${TEST_SRC_DIR}/wasm/onnxruntime_test_all_adapter.js)
-  set_target_properties(onnxruntime_test_all PROPERTIES LINK_FLAGS "-s STACK_SIZE=5242880 -s ALLOW_MEMORY_GROWTH=1 -s MAXIMUM_MEMORY=4294967296 --pre-js \"${TEST_SRC_DIR}/wasm/onnxruntime_test_all_adapter.js\" -s \"EXPORTED_RUNTIME_METHODS=['FS']\" --preload-file ${CMAKE_CURRENT_BINARY_DIR}/testdata@/testdata -s EXIT_RUNTIME=1 -s DEMANGLE_SUPPORT=1")
+  set_target_properties(onnxruntime_test_all PROPERTIES LINK_FLAGS "-s STACK_SIZE=5242880 -s ALLOW_MEMORY_GROWTH=1 -s MAXIMUM_MEMORY=4294967296 -s INCOMING_MODULE_JS_API=[preRun,locateFile,arguments,onExit,wasmMemory,buffer,instantiateWasm] --pre-js \"${TEST_SRC_DIR}/wasm/onnxruntime_test_all_adapter.js\" -s \"EXPORTED_RUNTIME_METHODS=['FS']\" --preload-file ${CMAKE_CURRENT_BINARY_DIR}/testdata@/testdata -s EXIT_RUNTIME=1 -s DEMANGLE_SUPPORT=1")
   if (onnxruntime_ENABLE_WEBASSEMBLY_THREADS)
     set_property(TARGET onnxruntime_test_all APPEND_STRING PROPERTY LINK_FLAGS " -s DEFAULT_PTHREAD_STACK_SIZE=131072 -s PROXY_TO_PTHREAD=1")
   endif()
diff --git a/cmake/onnxruntime_webassembly.cmake b/cmake/onnxruntime_webassembly.cmake
index 9014089cb6112..114638041e163 100644
--- a/cmake/onnxruntime_webassembly.cmake
+++ b/cmake/onnxruntime_webassembly.cmake
@@ -225,6 +225,7 @@ else()
     "SHELL:-s EXPORT_ALL=0"
     "SHELL:-s VERBOSE=0"
     "SHELL:-s FILESYSTEM=0"
+    "SHELL:-s INCOMING_MODULE_JS_API=[preRun,locateFile,arguments,onExit,wasmMemory,buffer,instantiateWasm,mainScriptUrlOrBlob]"
     ${WASM_API_EXCEPTION_CATCHING}
     --no-entry
   )
diff --git a/tools/ci_build/build.py b/tools/ci_build/build.py
index 5cc537c4596e8..d455c98ce1259 100644
--- a/tools/ci_build/build.py
+++ b/tools/ci_build/build.py
@@ -425,7 +425,7 @@ def convert_arg_line_to_args(self, arg_line):
     # WebAssembly build
     parser.add_argument("--build_wasm", action="store_true", help="Build for WebAssembly")
     parser.add_argument("--build_wasm_static_lib", action="store_true", help="Build for WebAssembly static library")
-    parser.add_argument("--emsdk_version", default="3.1.44", help="Specify version of emsdk")
+    parser.add_argument("--emsdk_version", default="3.1.51", help="Specify version of emsdk")
 
     parser.add_argument("--enable_wasm_simd", action="store_true", help="Enable WebAssembly SIMD")
     parser.add_argument("--enable_wasm_threads", action="store_true", help="Enable WebAssembly multi-threads support")
diff --git a/tools/ci_build/github/azure-pipelines/templates/linux-wasm-ci.yml b/tools/ci_build/github/azure-pipelines/templates/linux-wasm-ci.yml
index d67af8d23706f..e6693a6f6d26a 100644
--- a/tools/ci_build/github/azure-pipelines/templates/linux-wasm-ci.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/linux-wasm-ci.yml
@@ -93,15 +93,15 @@ jobs:
       - script: |
           set -ex
           cd '$(Build.SourcesDirectory)/cmake/external/emsdk'
-          ./emsdk install 3.1.44 ccache-git-emscripten-64bit
-          ./emsdk activate 3.1.44 ccache-git-emscripten-64bit
+          ./emsdk install 3.1.51 ccache-git-emscripten-64bit
+          ./emsdk activate 3.1.51 ccache-git-emscripten-64bit
         displayName: 'emsdk install and activate ccache for emscripten'
   - ${{if eq(parameters.WithCache, false)}}:
       - script: |
           set -ex
           cd '$(Build.SourcesDirectory)/cmake/external/emsdk'
-          ./emsdk install 3.1.44
-          ./emsdk activate 3.1.44
+          ./emsdk install 3.1.51
+          ./emsdk activate 3.1.51
         displayName: 'emsdk install and activate ccache for emscripten'
 
   - template: build-linux-wasm-step.yml