diff --git a/cmake/onnxruntime_python.cmake b/cmake/onnxruntime_python.cmake
index 07c65e7986b05..270139ceaff7b 100644
--- a/cmake/onnxruntime_python.cmake
+++ b/cmake/onnxruntime_python.cmake
@@ -97,8 +97,12 @@ endif()
 
 onnxruntime_add_include_to_target(onnxruntime_pybind11_state Python::Module Python::NumPy)
 target_include_directories(onnxruntime_pybind11_state PRIVATE ${ONNXRUNTIME_ROOT} ${pybind11_INCLUDE_DIRS})
-if(onnxruntime_USE_CUDA AND onnxruntime_CUDNN_HOME)
-    target_include_directories(onnxruntime_pybind11_state PRIVATE ${onnxruntime_CUDNN_HOME}/include)
+if(onnxruntime_USE_CUDA)
+    target_include_directories(onnxruntime_pybind11_state PRIVATE ${CMAKE_CUDA_TOOLKIT_INCLUDE_DIRECTORIES})
+    # cudnn_home is optional for Window when cuda and cudnn are installed in the same directory.
+    if(onnxruntime_CUDNN_HOME)
+      target_include_directories(onnxruntime_pybind11_state PRIVATE ${onnxruntime_CUDNN_HOME}/include)
+    endif()
 endif()
 if(onnxruntime_USE_CANN)
     target_include_directories(onnxruntime_pybind11_state PRIVATE ${onnxruntime_CANN_HOME}/include)