diff --git a/onnxruntime/core/optimizer/qdq_transformer/qdq_util.cc b/onnxruntime/core/optimizer/qdq_transformer/qdq_util.cc
index 221c06d7c8dcf..b1ab641a23256 100644
--- a/onnxruntime/core/optimizer/qdq_transformer/qdq_util.cc
+++ b/onnxruntime/core/optimizer/qdq_transformer/qdq_util.cc
@@ -54,9 +54,26 @@ bool IsQDQPairSupported(
   Initializer dq_zp(*dq_zp_tensor_proto, model_path);
   Initializer dq_scale(*dq_scale_tensor_proto, model_path);
 
-  return q_zp.data_type() == dq_zp.data_type() &&
-         SpanEq(q_zp.DataAsByteSpan(), dq_zp.DataAsByteSpan()) &&
-         *q_scale.data<float>() == *dq_scale.data<float>();
+  if (q_zp.data_type() != dq_zp.data_type() ||
+      q_scale.data_type() != q_scale.data_type() ||
+      !SpanEq(q_zp.DataAsByteSpan(), dq_zp.DataAsByteSpan())) {
+    return false;
+  }
+
+  switch (q_scale.data_type()) {
+    case ONNX_NAMESPACE::TensorProto::FLOAT:
+      return *q_scale.data<float>() == *dq_scale.data<float>();
+
+    case ONNX_NAMESPACE::TensorProto::FLOAT16:
+      return *q_scale.data<MLFloat16>() == *dq_scale.data<MLFloat16>();
+
+    case ONNX_NAMESPACE::TensorProto::BFLOAT16:
+      return *q_scale.data<BFloat16>() == *dq_scale.data<BFloat16>();
+
+    default:
+      assert(false);
+      return false;
+  }
 }
 
 bool IsDQSupported(const Node& dq_node, const GetConstantInitializerFn& get_const_initializer) {
diff --git a/onnxruntime/test/optimizer/graph_transform_test.cc b/onnxruntime/test/optimizer/graph_transform_test.cc
index ef6e2d531bc1a..5adcb3c150b8d 100755
--- a/onnxruntime/test/optimizer/graph_transform_test.cc
+++ b/onnxruntime/test/optimizer/graph_transform_test.cc
@@ -4602,38 +4602,43 @@ TEST_F(GraphTransformationTests, GeluApproximation_SessionOptionConfig) {
 }
 
 // Test DoubleQDQPairsRemover to remove unnecessary DQ->Q nodes in the middle
-TEST_F(GraphTransformationTests, DoublQDQRemover_RemoveDupQDQ) {
-  constexpr const ORTCHAR_T* model_uri = MODEL_FOLDER "qdq_optimization/dup_qdq.onnx";
-  std::shared_ptr<Model> p_model;
-  ASSERT_STATUS_OK(Model::Load(model_uri, p_model, nullptr, *logger_));
-  Graph& graph = p_model->MainGraph();
+TEST_F(GraphTransformationTests, DoublQDQRemover_RemoveDupQDQ_Float16) {
+  auto RunTest = [this](const ORTCHAR_T* model_uri) {
+    std::shared_ptr<Model> p_model;
+    ASSERT_STATUS_OK(Model::Load(model_uri, p_model, nullptr, *logger_));
+    Graph& graph = p_model->MainGraph();
 
-  onnxruntime::GraphTransformerManager graph_transformation_mgr{5};
-  ASSERT_STATUS_OK(graph_transformation_mgr.Register(std::make_unique<DoubleQDQPairsRemover>(), TransformerLevel::Level1));
-  ASSERT_STATUS_OK(graph_transformation_mgr.ApplyTransformers(graph, TransformerLevel::Level1, *logger_));
+    onnxruntime::GraphTransformerManager graph_transformation_mgr{5};
+    ASSERT_STATUS_OK(graph_transformation_mgr.Register(std::make_unique<DoubleQDQPairsRemover>(), TransformerLevel::Level1));
+    ASSERT_STATUS_OK(graph_transformation_mgr.ApplyTransformers(graph, TransformerLevel::Level1, *logger_));
 
-  std::map<std::string, int> op_to_count = CountOpsInGraph(graph);
-  EXPECT_EQ(op_to_count["QuantizeLinear"], 3);
-  EXPECT_EQ(op_to_count["DequantizeLinear"], 4);
+    std::map<std::string, int> op_to_count = CountOpsInGraph(graph);
+    EXPECT_EQ(op_to_count["QuantizeLinear"], 3);
+    EXPECT_EQ(op_to_count["DequantizeLinear"], 4);
 
-  std::string dq_scale_name_before_reshape_node;
-  std::string zp_name_before_reshape_node;
-  std::string dq_scale_name_after_reshape_node;
-  std::string zp_name_after_reshape_node;
-  for (auto& node : graph.Nodes()) {
-    if (node.Name() == "dq_2") {
-      dq_scale_name_before_reshape_node = node.InputDefs()[QDQ::InputIndex::SCALE_ID]->Name();
-      zp_name_before_reshape_node = node.InputDefs()[QDQ::InputIndex::ZERO_POINT_ID]->Name();
-    }
-    if (node.Name() == "q_3") {
-      dq_scale_name_after_reshape_node = node.InputDefs()[QDQ::InputIndex::SCALE_ID]->Name();
-      zp_name_after_reshape_node = node.InputDefs()[QDQ::InputIndex::ZERO_POINT_ID]->Name();
+    std::string dq_scale_name_before_reshape_node;
+    std::string zp_name_before_reshape_node;
+    std::string dq_scale_name_after_reshape_node;
+    std::string zp_name_after_reshape_node;
+    for (auto& node : graph.Nodes()) {
+      if (node.Name() == "dq_2") {
+        dq_scale_name_before_reshape_node = node.InputDefs()[QDQ::InputIndex::SCALE_ID]->Name();
+        zp_name_before_reshape_node = node.InputDefs()[QDQ::InputIndex::ZERO_POINT_ID]->Name();
+      }
+      if (node.Name() == "q_3") {
+        dq_scale_name_after_reshape_node = node.InputDefs()[QDQ::InputIndex::SCALE_ID]->Name();
+        zp_name_after_reshape_node = node.InputDefs()[QDQ::InputIndex::ZERO_POINT_ID]->Name();
+      }
     }
-  }
-  EXPECT_EQ(dq_scale_name_before_reshape_node.empty(), false);
-  EXPECT_EQ(zp_name_before_reshape_node.empty(), false);
-  EXPECT_EQ(dq_scale_name_before_reshape_node, dq_scale_name_after_reshape_node);
-  EXPECT_EQ(zp_name_before_reshape_node, zp_name_after_reshape_node);
+    EXPECT_EQ(dq_scale_name_before_reshape_node.empty(), false);
+    EXPECT_EQ(zp_name_before_reshape_node.empty(), false);
+    EXPECT_EQ(dq_scale_name_before_reshape_node, dq_scale_name_after_reshape_node);
+    EXPECT_EQ(zp_name_before_reshape_node, zp_name_after_reshape_node);
+  };
+
+  RunTest(MODEL_FOLDER "qdq_optimization/dup_qdq.onnx");
+  RunTest(MODEL_FOLDER "qdq_optimization/dup_qdq_float16.onnx");
+  RunTest(MODEL_FOLDER "qdq_optimization/dup_qdq_bfloat16.onnx");
 }
 
 // Test Gelu -> FastGelu
diff --git a/onnxruntime/test/testdata/transform/qdq_optimization/dup_qdq_bfloat16.onnx b/onnxruntime/test/testdata/transform/qdq_optimization/dup_qdq_bfloat16.onnx
new file mode 100644
index 0000000000000..a04b7781fca40
Binary files /dev/null and b/onnxruntime/test/testdata/transform/qdq_optimization/dup_qdq_bfloat16.onnx differ
diff --git a/onnxruntime/test/testdata/transform/qdq_optimization/dup_qdq_float16.onnx b/onnxruntime/test/testdata/transform/qdq_optimization/dup_qdq_float16.onnx
new file mode 100644
index 0000000000000..691da77969b1c
Binary files /dev/null and b/onnxruntime/test/testdata/transform/qdq_optimization/dup_qdq_float16.onnx differ