diff --git a/dune-project b/dune-project
index 43e444967f..d9997a2d8b 100644
--- a/dune-project
+++ b/dune-project
@@ -35,8 +35,6 @@
    (>= "5.1"))
   (cmdliner
    (>= "1.1.0"))
-  (base64
-   (>= "3.1.0"))
   dune-build-info
   (cppo :build)
   (ounit :with-test)
@@ -44,7 +42,6 @@
    (and
     :with-test
     (>= "3.9.0")))
-  (js_of_ocaml :with-test)
   (ppxlib
    (>= "0.24.0"))
   (menhir
diff --git a/melange.opam b/melange.opam
index 1828d97958..41cd7ae2c5 100644
--- a/melange.opam
+++ b/melange.opam
@@ -10,12 +10,10 @@ depends: [
   "dune" {>= "3.8"}
   "ocaml" {>= "5.1"}
   "cmdliner" {>= "1.1.0"}
-  "base64" {>= "3.1.0"}
   "dune-build-info"
   "cppo" {build}
   "ounit" {with-test}
   "reason" {with-test & >= "3.9.0"}
-  "js_of_ocaml" {with-test}
   "ppxlib" {>= "0.24.0"}
   "menhir" {>= "20201214"}
   "reactjs-jsx-ppx" {with-test}
diff --git a/nix/default.nix b/nix/default.nix
index e056c5547f..49b1adf3fb 100644
--- a/nix/default.nix
+++ b/nix/default.nix
@@ -50,7 +50,6 @@ buildDunePackage {
   nativeBuildInputs = [ menhir cppo git makeWrapper ];
   propagatedBuildInputs = [
     dune-build-info
-    base64
     cmdliner
     ppxlib
     menhirLib