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pharmacology.js
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//section: core pharmacology functions
function initcet() {
document.getElementById("card_infusion0").style.display = "none";
document.getElementById("card_cpt0").style.display = "none";
document.getElementById("card_cet0").style.display = "none";
document.getElementById("btn_displayhistory").innerHTML = "Scheme";
document.getElementById("status").innerHTML="Waiting to start";
//moved from start_cpt
//set drug_sets_index to zero
active_drug_set_index = 0;
drug_sets[active_drug_set_index].cpt_active = 0;
drug_sets[active_drug_set_index].cet_active = 0.5;
drug_sets[active_drug_set_index].IB_active = 0;
drug_sets[active_drug_set_index].firstrun = -1;
calculate_udfs(active_drug_set_index);
drug_sets[active_drug_set_index].cpt_rates = new Array();
drug_sets[active_drug_set_index].cpt_times = new Array();
drug_sets[active_drug_set_index].cpt_cp = new Array();
drug_sets[active_drug_set_index].cpt_ce = new Array();
drug_sets[active_drug_set_index].cpt_rates_real = new Array();
drug_sets[active_drug_set_index].volinf = new Array();
drug_sets[active_drug_set_index].historyarray = new Array();
drug_sets[active_drug_set_index].historyarrays = new Array();
drug_sets[active_drug_set_index].historytexts = new Array();
drug_sets[active_drug_set_index].cpt_bolus = 0;
drug_sets[active_drug_set_index].cet_bolus = 0;
drug_sets[active_drug_set_index].cpt_pause = 0;
drug_sets[active_drug_set_index].cet_pause = 0;
drug_sets[active_drug_set_index].cet_lockdowntime = 0;
drug_sets[active_drug_set_index].p_state = new Array();
drug_sets[active_drug_set_index].e_state = new Array();
p_state[1] = 0;
p_state[2] = 0;
p_state[3] = 0;
e_state[1] = 0;
e_state[2] = 0;
e_state[3] = 0;
e_state[4] = 0;
/*?can remove -> used for bolus admin stuff
l1 = Math.exp(-lambda[1] );
l2 = Math.exp(-lambda[2] );
l3 = Math.exp(-lambda[3] );
l4 = Math.exp(-lambda[4] );
*/
}
function initcet_complex(drug_sets_index) {
document.getElementById("card_cet" + drug_sets_index + "_new").style.display = "";
document.getElementById("card_cet" + drug_sets_index + "_new").classList.add("hide");
document.getElementById("card_infusion" + drug_sets_index).style.display = "none";
document.getElementById("card_cpt" + drug_sets_index).style.display = "none";
document.getElementById("card_cet" + drug_sets_index).style.display = "none";
document.getElementById("btn_displayhistory").innerHTML = "Scheme";
document.getElementById("status").innerHTML="Waiting to start";
drug_sets[drug_sets_index].cet_active = 0.5;
drug_sets[drug_sets_index].firstrun = -1;
drug_sets[drug_sets_index].IB_active = 0;
calculate_udfs(drug_sets_index);
// initialize params
drug_sets[drug_sets_index].cpt_rates = new Array();
drug_sets[drug_sets_index].cpt_times = new Array();
drug_sets[drug_sets_index].cpt_cp = new Array();
drug_sets[drug_sets_index].cpt_ce = new Array();
drug_sets[drug_sets_index].cpt_rates_real = new Array();
drug_sets[drug_sets_index].volinf = new Array();
drug_sets[drug_sets_index].historyarray = new Array();
drug_sets[drug_sets_index].historyarrays = new Array();
drug_sets[drug_sets_index].historytexts = new Array();
drug_sets[drug_sets_index].cpt_bolus = 0;
drug_sets[drug_sets_index].cet_bolus = 0;
drug_sets[drug_sets_index].cpt_pause = 0;
drug_sets[drug_sets_index].cet_pause = 0;
drug_sets[drug_sets_index].cet_lockdowntime = 0;
drug_sets[drug_sets_index].p_state = new Array();
drug_sets[drug_sets_index].e_state = new Array();
p_state[1] = 0;
p_state[2] = 0;
p_state[3] = 0;
e_state[1] = 0;
e_state[2] = 0;
e_state[3] = 0;
e_state[4] = 0;
}
function initcpt_complex(drug_sets_index) {
document.getElementById("card_cpt" + drug_sets_index).style.display = "";
document.getElementById("card_cpt" + drug_sets_index).classList.add("hide");
document.getElementById("card_infusion" + drug_sets_index).style.display = "none";
document.getElementById("card_cet" + drug_sets_index).style.display = "none";
document.getElementById("card_cet" + drug_sets_index + "_new").style.display = "none";
document.getElementById("btn_displayhistory").innerHTML = "Scheme";
document.getElementById("status").innerHTML="Waiting to start";
drug_sets[drug_sets_index].cpt_active = 0.5;
drug_sets[drug_sets_index].firstrun = -1;
calculate_udfs(drug_sets_index);
// initialize params
drug_sets[drug_sets_index].cpt_rates = new Array();
drug_sets[drug_sets_index].cpt_times = new Array();
drug_sets[drug_sets_index].cpt_cp = new Array();
drug_sets[drug_sets_index].cpt_ce = new Array();
drug_sets[drug_sets_index].cpt_rates_real = new Array();
drug_sets[drug_sets_index].volinf = new Array();
drug_sets[drug_sets_index].historyarray = new Array();
drug_sets[drug_sets_index].historyarrays = new Array();
drug_sets[drug_sets_index].historytexts = new Array();
drug_sets[drug_sets_index].cpt_bolus = 0;
drug_sets[drug_sets_index].cet_bolus = 0;
drug_sets[drug_sets_index].cpt_pause = 0;
drug_sets[drug_sets_index].cet_pause = 0;
drug_sets[drug_sets_index].cet_lockdowntime = 0;
drug_sets[drug_sets_index].p_state = new Array();
drug_sets[drug_sets_index].e_state = new Array();
p_state[1] = 0;
p_state[2] = 0;
p_state[3] = 0;
e_state[1] = 0;
e_state[2] = 0;
e_state[3] = 0;
e_state[4] = 0;
}
function initcetbolus(ind) {
document.getElementById("card_infusion" + ind).style.display = "none";
document.getElementById("card_cpt" + ind).style.display = "none";
document.getElementById("card_cet" + ind + "_new").style.display = "none";
document.getElementById("card_cet" + ind).style.display = "";
document.getElementById("card_cet" + ind).classList.add("hide");
document.getElementById("btn_displayhistory").innerHTML = "Scheme";
drug_sets[ind].cpt_active = 0;
drug_sets[ind].cet_active = 0.5;
drug_sets[ind].IB_active = 1;
drug_sets[ind].IB_swing = 0.05;
drug_sets[ind].firstrun = -1;
calculate_udfs(ind);
drug_sets[ind].cpt_rates = new Array();
drug_sets[ind].cpt_times = new Array();
drug_sets[ind].cpt_cp = new Array();
drug_sets[ind].cpt_ce = new Array();
drug_sets[ind].cpt_rates_real = new Array();
drug_sets[ind].volinf = new Array();
drug_sets[ind].historyarray = new Array();
drug_sets[ind].historyarrays = new Array();
drug_sets[ind].historytexts = new Array();
drug_sets[ind].cpt_bolus = 0;
drug_sets[ind].cet_bolus = 0;
drug_sets[ind].cpt_pause = 0;
drug_sets[ind].cet_pause = 0;
drug_sets[ind].cet_lockdowntime = 0;
drug_sets[ind].p_state = new Array();
drug_sets[ind].e_state = new Array();
document.getElementById("status").innerHTML="Waiting to start";
//moved from start_cpt
p_state[1] = 0;
p_state[2] = 0;
p_state[3] = 0;
e_state[1] = 0;
e_state[2] = 0;
e_state[3] = 0;
e_state[4] = 0;
//l1 = Math.exp(-drug_sets[active_drug_set_index].lambda[1] );
//l2 = Math.exp(-drug_sets[active_drug_set_index].lambda[2] );
//l3 = Math.exp(-drug_sets[active_drug_set_index].lambda[3] );
//l4 = Math.exp(-drug_sets[active_drug_set_index].lambda[4] );
//UI change
document.getElementById("card_cet" + ind).querySelector(".cardtitle").innerHTML = "INTERMITTENT BOLUS";
document.getElementById("btn_startCet" + ind).setAttribute("onclick", "start_cet_bolus()");
document.getElementById("IB_about_btn" + ind).style.display = "block";
document.getElementById("progressbar").style.display = "block";
//document.getElementById("IB_description").style.display = "block";
//var IBelem = document.getElementsByClassName("IB_elements");
//for (u=0; u<IBelem.length; u++) {
// IBelem[u].style.display= "table-row";
//}
document.getElementById("IB_swing_select_row" + ind).style.display = "table-row";
document.getElementById("IB_interval_row" + ind).style.display = "table-row";
var tempmodel = document.getElementById("modelname").innerText;
if (drug_sets[ind].drug_name=="Propofol") {
if (tempmodel=="Marsh") {
document.getElementById("IB_interval" + ind).innerText = "1.5-2min";
}
if (tempmodel=="Schnider") {
document.getElementById("IB_interval" + ind).innerText = "1.5-2min";
}
if (tempmodel=="Eleveld") {
document.getElementById("IB_interval" + ind).innerText = "3.5-4min";
}
if (tempmodel=="Paedfusor") {
document.getElementById("IB_interval" + ind).innerText = "2.5-3.5min";
}
if (tempmodel=="Maitre") {
document.getElementById("IB_interval" + ind).innerText = "2.5-5min";
}
}
if (drug_sets[ind].drug_name=="Remifentanil") {
document.getElementById("IB_swing_select" + ind).options[0].disabled = true;
document.getElementById("IB_swing_select" + ind).options[1].disabled = true;
document.getElementById("IB_swing_select" + ind).options[2].selected = true;
drug_sets[ind].IB_swing = 0.075;
document.getElementById("IB_swing_select" + ind).value = drug_sets[ind].IB_swing;
}
//unhide if propofol
if (ind == 0) {
document.getElementById("card_cet" + ind).classList.remove("hide");
}
}
function initmanual(ind) {
drug_sets[ind].cpt_active = 0;
drug_sets[ind].cet_active = 0;
drug_sets[ind].manualmode_active = 1;
drug_sets[ind].firstrun = -1;
calculate_udfs(ind);
// initialize params
drug_sets[ind].cpt_rates = new Array();
drug_sets[ind].cpt_times = new Array();
drug_sets[ind].cpt_cp = new Array();
drug_sets[ind].cpt_ce = new Array();
drug_sets[ind].cpt_rates_real = new Array();
drug_sets[ind].volinf = new Array();
drug_sets[ind].historyarray = new Array();
drug_sets[ind].historyarrays = new Array();
drug_sets[ind].historytexts = new Array();
drug_sets[ind].cpt_bolus = 0;
drug_sets[ind].cet_bolus = 0;
drug_sets[ind].historytext = "";
p_state[1] = 0;
p_state[2] = 0;
p_state[3] = 0;
e_state[1] = 0;
e_state[2] = 0;
e_state[3] = 0;
e_state[4] = 0;
drug_sets[ind].desired = 0;
//l1 = Math.exp(-drug_sets[active_drug_set_index].lambda[1] );
//l2 = Math.exp(-drug_sets[active_drug_set_index].lambda[2] );
//l3 = Math.exp(-drug_sets[active_drug_set_index].lambda[3] );
//l4 = Math.exp(-drug_sets[active_drug_set_index].lambda[4] );
document.getElementById("card_infusion" + ind).style.display = "";
document.getElementById("card_infusion" + ind).classList.add("hide");
//document.getElementById("card_bolus" + ind).style.display = "none"; -->no need this, otherwise tabswitch bug
document.getElementById("card_bolus" + ind).classList.add("hide");
document.getElementById('card_cpt' + ind).style.display = 'none';
document.getElementById('card_cet' + ind).style.display = 'none';
document.getElementById('card_cet' + ind + "_new").style.display = 'none';
//document.getElementById('card_TimeEstimation').style.display = 'none';
//document.getElementById('card_VolumeEstimation').style.display = 'none';
document.getElementById("schemecopytitle").innerHTML = "HISTORY";
document.getElementById("pastschemeCOPY").style.display = "none";
//unhide if this is propofol, first run
if (ind==0) {
document.getElementById("card_infusion" + ind).classList.remove("hide");
}
}
function start_cet() {
active_drug_set_index = 0;
if (complex_mode == 1) {
if ((drug_sets[active_drug_set_index].firstrun == -1) && (drug_sets[alt_drug_set_index].firstrun == -1)) {
common_start_calls();
}
} else if (drug_sets[active_drug_set_index].firstrun == -1) {
common_start_calls();
}
if (drug_sets[active_drug_set_index].firstrun == -1) {
if (document.getElementById("inputDesiredCe0_new").value>0) {
drug_sets[active_drug_set_index].desired = 0;
drug_sets[active_drug_set_index].firstrun = 0;
drug_sets[active_drug_set_index].running = 1;
offset = Date.now();
if (document.getElementById("inputDesiredCe0_new").value>0) {
desired = document.getElementById("inputDesiredCe0_new").value *1;
}
drug_sets[active_drug_set_index].cet_active = 1;
deliver_cet(desired, active_drug_set_index);
//UI code goes here
drug_sets[active_drug_set_index].running = 1;
document.getElementById("status").innerHTML="";
document.getElementById("btn_startCet0_new").innerHTML = `<div class="icon"><i class="fas fa-play fa-fw"></i></div><div class="input-button-text">Enter</div></a>`;
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("pastscheme").classList.add("show");
} else {
displayWarning("Warning","CE Target Invalid.");
document.getElementById("inputDesiredCe0_new").value = "";
}
} else {
if (document.getElementById("inputDesiredCe0_new").value>0) {
desired = document.getElementById("inputDesiredCe0_new").value *1;
drug_sets[active_drug_set_index].running = 1;
document.getElementById("status").innerHTML="";
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
drug_sets[active_drug_set_index].cet_active = 1;
deliver_cet(desired,0);
} else {
displayWarning("Warning","CE Target Invalid.");
document.getElementById("inputDesiredCe0_new").value = "";
}
}
alert_api(0);
displaypreview_hide_onsubmit();
}
function start_cpt_complex(cpt_complex_desired, active_drug_set_index) {
if ((drug_sets[active_drug_set_index].firstrun == -1) && (drug_sets[alt_drug_set_index].firstrun == -1)) {
common_start_calls();
}
if (drug_sets[active_drug_set_index].firstrun == -1) {
if (cpt_complex_desired > 0) {
offset = Date.now();
desired = document.getElementById("inputDesired1").value *1;
drug_sets[active_drug_set_index].cpt_active = 1;
drug_sets[active_drug_set_index].desired = desired;
drug_sets[active_drug_set_index].firstrun = 0;
drug_sets[active_drug_set_index].running = 1;
// initialize params (moved away to initcpt)
deliver_cpt(desired, 0, 0, 1); // 4th argument is drug set index (3rd arg is compensation)
//UI code goes here
document.getElementById("status").innerHTML="";
document.getElementById("btn_startCpt1_new").innerHTML = `<div class="icon"><i class="fas fa-play fa-fw"></i></div><div class="input-button-text">Enter</div></a>`;
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("pastscheme").classList.add("show");
loop4 = setInterval(updatechart2, 5000);
loop5 = setInterval(updatechart3, 1000);
setTimeout(function(){
updatechart3(1);
},500);
} else {
displayWarning("Warning","CP Target Invalid.");
document.getElementById("inputDesired1").value = "";
}
} else {
if (document.getElementById("inputDesired1").value>0) {
//desired = document.getElementById("inputDesired1").value *1;
drug_sets[active_drug_set_index].running = 1;
document.getElementById("status").innerHTML="";
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
drug_sets[active_drug_set_index].cpt_active = 1;
deliver_cpt(cpt_complex_desired, 0, 0, 1);
setTimeout(function(){
updatechart3(1);
},500);
} else {
displayWarning("Warning","CP Target Invalid.");
document.getElementById("inputDesired1").value = "";
}
}
displaypreview_hide_onsubmit();
}
function start_cet_complex(cet_complex_desired, active_drug_set_index) {
if ((drug_sets[active_drug_set_index].firstrun == -1) && (drug_sets[alt_drug_set_index].firstrun == -1)) {
common_start_calls();
}
if (drug_sets[active_drug_set_index].firstrun == -1) {
/*
document.getElementById("top_subtitle").classList.add("topClose");
document.getElementById("top_title").classList.add("topOpen");
initshare();
*/
//if (document.getElementById("inputDesiredCe").value>0) {
if (cet_complex_desired>0) {
loop4 = setInterval(updatechart2, 5000);
loop5 = setInterval(updatechart3, 1000);
drug_sets[active_drug_set_index].desired = 0;
drug_sets[active_drug_set_index].firstrun = 0;
drug_sets[active_drug_set_index].running = 1;
offset = Date.now();
/*
if (document.getElementById("inputDesiredCe").value>0) {
desired = document.getElementById("inputDesiredCe").value *1;
}
*/
drug_sets[active_drug_set_index].cet_active = 1;
// initialize params
drug_sets[active_drug_set_index].cpt_rates = new Array();
drug_sets[active_drug_set_index].cpt_times = new Array();
drug_sets[active_drug_set_index].cpt_cp = new Array();
drug_sets[active_drug_set_index].cpt_ce = new Array();
drug_sets[active_drug_set_index].cpt_rates_real = new Array();
drug_sets[active_drug_set_index].volinf = new Array();
drug_sets[active_drug_set_index].historyarray = new Array();
drug_sets[active_drug_set_index].historyarrays = new Array();
drug_sets[active_drug_set_index].historytexts = new Array();
drug_sets[active_drug_set_index].cpt_bolus = 0;
drug_sets[active_drug_set_index].cet_bolus = 0;
drug_sets[active_drug_set_index].cpt_pause = 0;
drug_sets[active_drug_set_index].cet_pause = 0;
drug_sets[active_drug_set_index].cet_lockdowntime = 0;
deliver_cet(cet_complex_desired, active_drug_set_index);
//loop1 = setInterval(update, 500);
//loop2 = setInterval(runinfusion2, refresh_interval);
//loop3 = setInterval(updatechart, 5000);
//UI code goes here
drug_sets[active_drug_set_index].running = 1;
setTimeout(function(){
updatechart3(1);
},500);
document.getElementById("status").innerHTML="";
document.getElementById("btn_startCet1").innerHTML = "Update Cet";
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("pastscheme").classList.add("show");
} else {
displayWarning("Warning","CE Target Invalid.");
document.getElementById("inputDesiredCe1_new").value = "";
}
} else {
// if (document.getElementById("inputDesiredCe").value>0) {
if (cet_complex_desired>0) {
//desired = document.getElementById("inputDesiredCe").value *1;
drug_sets[active_drug_set_index].running = 1;
document.getElementById("status").innerHTML="";
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
drug_sets[active_drug_set_index].cet_active = 1;
deliver_cet(cet_complex_desired,active_drug_set_index);
setTimeout(function(){
updatechart3(1);
},500);
} else {
displayWarning("Warning","CE Target Invalid.");
document.getElementById("inputDesiredCe1_new").value = "";
}
}
displaypreview_hide_onsubmit();
}
function start_cet_bolus() {
if (complex_mode ==1) {
if ((drug_sets[active_drug_set_index].firstrun == -1) && (drug_sets[alt_drug_set_index].firstrun == -1)) {
common_start_calls();
}
} else if (drug_sets[active_drug_set_index].firstrun == -1) {
common_start_calls();
}
if (drug_sets[active_drug_set_index].firstrun == -1) {
if (document.getElementById("inputDesiredCe" + active_drug_set_index).value>0) {
drug_sets[active_drug_set_index].desired = 0;
drug_sets[active_drug_set_index].firstrun = 0;
drug_sets[active_drug_set_index].running = 1;
offset = Date.now();
if (document.getElementById("inputDesiredCe" + active_drug_set_index).value>0) {
drug_sets[active_drug_set_index].desired = document.getElementById("inputDesiredCe" + active_drug_set_index).value *1;
}
drug_sets[active_drug_set_index].cet_active = 1;
// initialize params
drug_sets[active_drug_set_index].cpt_rates = new Array();
drug_sets[active_drug_set_index].cpt_times = new Array();
drug_sets[active_drug_set_index].cpt_cp = new Array();
drug_sets[active_drug_set_index].cpt_ce = new Array();
drug_sets[active_drug_set_index].cpt_rates_real = new Array();
drug_sets[active_drug_set_index].volinf = new Array();
drug_sets[active_drug_set_index].historyarray = new Array();
drug_sets[active_drug_set_index].historyarrays = new Array();
drug_sets[active_drug_set_index].historytexts = new Array();
drug_sets[active_drug_set_index].cpt_bolus = 0;
drug_sets[active_drug_set_index].cet_bolus = 0;
drug_sets[active_drug_set_index].cpt_pause = 0;
drug_sets[active_drug_set_index].cet_pause = 0;
drug_sets[active_drug_set_index].cet_lockdowntime = 0;
deliver_cet_alt(drug_sets[active_drug_set_index].desired);
document.getElementById("status").innerHTML="";
document.getElementById("btn_startCet" + active_drug_set_index).innerHTML = "Update Cet";
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("pastscheme").classList.add("show");
if ((complex_mode == 1) && (drug_sets[0].firstrun > -1) && (drug_sets[1].firstrun>-1)) {
loop4 = setInterval(updatechart2, 5000);
loop5 = setInterval(updatechart3, 1000);
setTimeout(function(){
updatechart3(1);
},500);
}
} else {
displayWarning("Warning","CE Target Invalid.");
document.getElementById("inputDesiredCe" + active_drug_set_index).value = "";
}
} else {
if (document.getElementById("inputDesiredCe" + active_drug_set_index).value>0) {
drug_sets[active_drug_set_index].desired = document.getElementById("inputDesiredCe" + active_drug_set_index).value *1;
drug_sets[active_drug_set_index].running = 1;
document.getElementById("status").innerHTML="";
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
drug_sets[active_drug_set_index].cet_active = 1;
deliver_cet_alt(drug_sets[active_drug_set_index].desired);
} else {
displayWarning("Warning","CE Target Invalid.");
document.getElementById("inputDesiredCe" + active_drug_set_index).value = "";
}
}
alert_api(0);
}
function start_manual(ind) { //this is new
if (complex_mode == 1) {
if ((drug_sets[active_drug_set_index].firstrun == -1) && (drug_sets[alt_drug_set_index].firstrun == -1)) {
common_start_calls();
}
} else if (drug_sets[ind].firstrun == -1) {
common_start_calls();
}
if (drug_sets[ind].firstrun == -1) { //first run
//document.getElementById("top_subtitle").classList.add("topClose");
//document.getElementById("top_title").classList.add("topOpen");
//initshare();
offset = Date.now();
if (optionsarray_infusionunit[0][0] == 1) {
drug_sets[ind].inf_rate_mls = document.getElementById("inputInfusion" + ind).value *1;
} else {
//otherwise convert to ml/h first
drug_sets[ind].inf_rate_mls = document.getElementById("inputInfusion" + ind).value/drug_sets[active_drug_set_index].infusate_concentration/drug_sets[active_drug_set_index].inf_rate_permass_factor*mass;
}
//special code to account for "lost time" for delayed start in complex mode
if (complex_mode == 1) {
working_clock = Math.floor(time_in_s);
for (i=0; i<working_clock; i++) {
drug_sets[ind].cpt_rates_real.push(0);
drug_sets[ind].cpt_cp.push([0,0,0]);
drug_sets[ind].cpt_ce.push([0,0,0,0]);
drug_sets[ind].volinf.push(0)
}
myChart.data.datasets[ind*2+2].data.push({x:(working_clock-1)/60, y:0});
myChart.data.datasets[ind*2+3].data.push({x:(working_clock-1)/60, y:0});
//loop4 = setInterval(updatechart2, 1000);
//loop5 = setInterval(updatechart3, 1000*30);
setTimeout(function(){
updatechart3(1);
},500);
}
drug_sets[ind].firstrun = 0;
drug_sets[ind].running = 1;
if (document.getElementById("inputBolus_initial" + ind).value>0) {
temp_bolus = document.getElementById("inputBolus_initial" + ind).value * 1;
if (optionsarray_infusionunit[1][0] == 1) {
bolusadmin(temp_bolus,ind);
} else if (optionsarray_infusionunit[1][1] == 1) {
bolusadmin(temp_bolus * mass,ind);
} else {
bolusadmin(temp_bolus * drug_sets[ind].infusate_concentration,ind);
}
} else {
lookahead(0,21600,ind);
}
//UI code goes here
document.getElementById("btn_start" + ind).innerHTML = "Update Rate";
document.getElementById("tableInitialBolus" + ind).style.display = "none";
document.getElementById("tableInfusionRate" + ind).classList.remove("line");
document.getElementById("card_bolus" + ind).style.display ="";
document.getElementById("card_bolus" + ind).classList.remove("hide");
document.getElementById("status").innerHTML="Running";
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
if ((complex_mode == 1) && (drug_sets[0].firstrun > -1) && (drug_sets[1].firstrun > -1)) {
loop4 = setInterval(updatechart2, 5000);
loop5 = setInterval(updatechart3, 1000);
setTimeout(function(){
updatechart3(1);
},500);
}
} else {
document.getElementById("prompt_msg2").innerHTML = "Current rate";
if (optionsarray_infusionunit[0][0] == 1) {
drug_sets[ind].inf_rate_mls = document.getElementById("inputInfusion" + ind).value *1;
} else {
//otherwise convert to ml/h first
drug_sets[ind].inf_rate_mls = document.getElementById("inputInfusion" + ind).value/drug_sets[active_drug_set_index].infusate_concentration/drug_sets[active_drug_set_index].inf_rate_permass_factor*mass;
}
document.getElementById("status").innerHTML="Running";
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
lookahead(0,21600,ind);//start button name already changed to "updaterate"
}
}
function start() { // this will be obsolete
if (firstrun == -1) { //first run
offset = Date.now();
inf_rate_mls = document.getElementById("inputInfusion").value *1;
inf_rate_mgperkg = inf_rate_mls*10/mass;
historytext = "<br>" + "Time: " + time_in_s + "s - Rate: " + inf_rate_mls + "ml/h";
calculate_udfs();
p_state[1] = 0;
p_state[2] = 0;
p_state[3] = 0;
e_state[1] = 0;
e_state[2] = 0;
e_state[3] = 0;
e_state[4] = 0;
desired = 0;
loop1 = setInterval(update, 100);
//init patient states
loop2 = setInterval(runinfusion, refresh_interval);
loop3 = setInterval(updatechart, 3000, myChart);
loop4 = setInterval(lookahead, 6000);
if (document.getElementById("inputBolus_initial").value>0) {
bolusadmin(document.getElementById("inputBolus_initial").value * 1);
}
firstrun = 0;
running = 1;
document.getElementById("btn_start").innerHTML = "Update Rate";
document.getElementById("tableInitialBolus").style.display = "none";
document.getElementById("tableInfusionRate").classList.remove("line");
document.getElementById("card_bolus").style.display ="block";
document.getElementById("card_cpt").style.display ="none";
document.getElementById("status").innerHTML="Running";
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
} else {
updateinfusion();//start button name already changed to "updaterate"
}
}
function start_cpt() {
//enter read 'desired' code here, otherwise manual command line entry
//reading 'desired' code here
active_drug_set_index = 0;
if (complex_mode == 1) {
if ((drug_sets[active_drug_set_index].firstrun == -1) && (drug_sets[alt_drug_set_index].firstrun == -1)) {
common_start_calls();
}
} else if (drug_sets[active_drug_set_index].firstrun == -1) {
common_start_calls();
}
if (drug_sets[active_drug_set_index].firstrun == -1) {
if (document.getElementById("inputDesired0").value>0) {
offset = Date.now();
desired = document.getElementById("inputDesired0").value *1;
drug_sets[active_drug_set_index].cpt_active = 1;
drug_sets[active_drug_set_index].desired = desired;
drug_sets[active_drug_set_index].firstrun = 0;
drug_sets[active_drug_set_index].running = 1;
deliver_cpt(desired, 0, 0, 0); // 4th argument is drug set index (3rd arg is compensation)
//UI code goes here
document.getElementById("status").innerHTML="";
document.getElementById("btn_startCpt0_new").innerHTML = `<div class="icon"><i class="fas fa-play fa-fw"></i></div><div class="input-button-text">Enter</div></a>`;
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("pastscheme").classList.add("show");
} else {
displayWarning("Warning","CP Target Invalid.");
document.getElementById("inputDesired0").value = "";
}
} else {
if (document.getElementById("inputDesired0").value>0) {
desired = document.getElementById("inputDesired0").value *1;
drug_sets[active_drug_set_index].cpt_active = 1;
drug_sets[active_drug_set_index].running = 1;
document.getElementById("status").innerHTML="";
document.getElementById("iconplay").classList.remove("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
document.getElementById("iconplay").innerHTML="<i class='fas fa-play fa-lg'></i>";
deliver_cpt(desired, 0, 0,0);
} else {
displayWarning("Warning","CP Target Invalid.");
document.getElementById("inputDesired0").value = "";
}
}
alert_api(0);
displaypreview_hide_onsubmit();
}
function pause(ind) {
drug_sets[ind].inf_rate_mls = 0;
document.getElementById("inputInfusion" + ind).value = "0";
lookahead(0,21600,ind);
document.getElementById("iconplay").classList.add("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-pause fa-lg'></i>";
document.getElementById("status").innerHTML="Paused";
}
function pauseCpt(ind) {
drug_sets[ind].desired = 0;
if (parseloading == 0) {
document.getElementById("inputDesired" + ind).value = "0";
document.getElementById("inputDesiredCe" + ind + "_new").value = "0";
}
drug_sets[ind].running=0;
var working_clock = Math.floor(time_in_s);
//backup current P state and E state s
if (drug_sets[ind].cpt_cp.length>0) {
p_state[1] = drug_sets[ind].cpt_cp[working_clock-1][0];
p_state[2] = drug_sets[ind].cpt_cp[working_clock-1][1];
p_state[3] = drug_sets[ind].cpt_cp[working_clock-1][2];
e_state[1] = drug_sets[ind].cpt_ce[working_clock-1][0];
e_state[2] = drug_sets[ind].cpt_ce[working_clock-1][1];
e_state[3] = drug_sets[ind].cpt_ce[working_clock-1][2];
e_state[4] = drug_sets[ind].cpt_ce[working_clock-1][3];
}
p_state2[1] = p_state[1];
p_state2[2] = p_state[2];
p_state2[3] = p_state[3];
e_state2[1] = e_state[1];
e_state2[2] = e_state[2];
e_state2[3] = e_state[3];
e_state2[4] = e_state[4];
p_state3[1] = p_state[1];
p_state3[2] = p_state[2];
p_state3[3] = p_state[3];
e_state3[1] = e_state[1];
e_state3[2] = e_state[2];
e_state3[3] = e_state[3];
e_state3[4] = e_state[4];
//pop the arrays
drug_sets[ind].cpt_rates.length = 0;
drug_sets[ind].cpt_times.length = 0;
drug_sets[ind].historyarray.length = 0;
//set the real rates delivery array to current length in time_in_s
drug_sets[ind].cpt_rates_real.length = working_clock;
drug_sets[ind].cpt_cp.length = working_clock;
drug_sets[ind].cpt_ce.length = working_clock;
drug_sets[ind].volinf.length = working_clock;
myChart.data.datasets[ind*2+2].data.length = myChart.data.datasets[ind*2+2].data.findIndex((element)=>element.x>time_in_s/60);
myChart.data.datasets[ind*2+3].data.length = myChart.data.datasets[ind*2+3].data.findIndex((element)=>element.x>time_in_s/60);
var look_l1 = Math.exp(-drug_sets[ind].lambda[1] );
var look_l2 = Math.exp(-drug_sets[ind].lambda[2] );
var look_l3 = Math.exp(-drug_sets[ind].lambda[3] );
var look_l4 = Math.exp(-drug_sets[ind].lambda[4] );
var temp_result, temp_result_e;
var temp_vol = drug_sets[ind].volinf[working_clock-1];
for (j=0; j<21600; j++) {
p_state3[1] = p_state3[1] * look_l1 ;
p_state3[2] = p_state3[2] * look_l2 ;
p_state3[3] = p_state3[3] * look_l3 ;
//if (effect_data)
// {
e_state3[1] = e_state3[1] * look_l1 ;
e_state3[2] = e_state3[2] * look_l2 ;
e_state3[3] = e_state3[3] * look_l3 ;
e_state3[4] = e_state3[4] * look_l4 ;
//prior_test_rate = test_rate;
temp_result = p_state3[1] + p_state3[2] + p_state3[3];
temp_result_e = e_state3[1] + e_state3[2] + e_state3[3] + e_state3[4];
drug_sets[ind].cpt_cp.push([p_state3[1],p_state3[2],p_state3[3]]);
drug_sets[ind].cpt_ce.push([e_state3[1],e_state3[2],e_state3[3],e_state3[4]]);
drug_sets[ind].volinf.push(temp_vol);
drug_sets[ind].cpt_rates_real.push(0);
//if (j%60 ==0) {console.log(j + "real rate " + test_rate*3600/10 + " real Cp " + result);}
if ((j<1800) && (j%10==0)) {
myChart.data.datasets[ind*2+2].data.push({x:(working_clock+j)/60, y:temp_result});
myChart.data.datasets[ind*2+3].data.push({x:(working_clock+j)/60, y:temp_result_e});
}
if ((j>=1800) && (j<7200) && (j%60==0)) {
myChart.data.datasets[ind*2+2].data.push({x:(working_clock+j)/60, y:temp_result});
myChart.data.datasets[ind*2+3].data.push({x:(working_clock+j)/60, y:temp_result_e});
}
if ((j>=7200) && (j%120==0)) {
myChart.data.datasets[ind*2+2].data.push({x:(working_clock+j)/60, y:temp_result});
myChart.data.datasets[ind*2+3].data.push({x:(working_clock+j)/60, y:temp_result_e});
}
}
processhistory();
drug_sets[ind].historytext = "<div class='schemecpt' data-time='" + working_clock + "'>" + "At " + converttime(working_clock) + " - target set zero.</div>";
drug_sets[ind].historytext = drug_sets[ind].historytext.concat("<div class='schemeinf' data-time='" + working_clock + "'>" + "Infusion paused</div>");
drug_sets[ind].historyarray.push([working_clock, 0]);
drug_sets[ind].historyarrays.push([,0,working_clock,0]);
document.getElementById("historywrapper").innerHTML = drug_sets[ind].historytext;
historydivs = document.getElementById("historywrapper").querySelectorAll("[data-time]"); // need to self-write history divs because of update() will not function
document.getElementById("iconplay").classList.add("stop");
document.getElementById("iconplay").innerHTML="<i class='fas fa-pause fa-lg'></i>";
document.getElementById("status").innerHTML="Paused";
document.getElementById("prompt_msg2").innerHTML = "Current target: 0";
document.getElementById("warning").style.display = "none";
document.getElementById("infusiondescriptor").innerHTML="";
document.getElementById("top_infrate").style.display = "none";
if (parseloading == 0) {
savefile_data();
ptol_generate_margins(ind,0.9,0.5);
} else {
myChart.update();
}
}
function runinfusion2() {
drug_sets[0].inf_rate_mls = getinfusionrate(time_in_s,0);
drug_sets[0].inf_rate_permass = drug_sets[0].inf_rate_mls*drug_sets[0].infusate_concentration*drug_sets[0].inf_rate_permass_factor/mass;
result = Math.round(getcp(time_in_s,0)*100)/100;
result_e = Math.round(getce(time_in_s,0)*100)/100;
displayresult(result, result_e);
}
function runinfusion_complex() {
if (drug_sets[active_drug_set_index].running > -1) {
drug_sets[active_drug_set_index].inf_rate_mls = getinfusionrate(time_in_s,active_drug_set_index);
drug_sets[active_drug_set_index].inf_rate_permass = drug_sets[active_drug_set_index].inf_rate_mls*drug_sets[active_drug_set_index].infusate_concentration*drug_sets[active_drug_set_index].inf_rate_permass_factor/mass;
result = Math.round(getcp(time_in_s,active_drug_set_index)*10)/10;
result_e = Math.round(getce(time_in_s,active_drug_set_index)*10)/10;
displayresult(result,result_e) ;
} else {
displayresult(0,0);
}
//document.getElementById("cp_propo").innerHTML = result;
//document.getElementById("ce_propo").innerHTML = result_e;
//document.getElementById("inf_propo").innerHTML = drug_sets[active_drug_set_index].inf_rate_mls;
//if (drug_sets[active_drug_set_index].manualmode_active == 1) {
// displayresult(result, result_e);
//}
if (drug_sets.length==2) {
drug_sets[alt_drug_set_index].inf_rate_mls = getinfusionrate(time_in_s,alt_drug_set_index);
drug_sets[alt_drug_set_index].inf_rate_permass = drug_sets[alt_drug_set_index].inf_rate_mls*drug_sets[alt_drug_set_index].infusate_concentration*drug_sets[alt_drug_set_index].inf_rate_permass_factor/mass;
alt_result = Math.round(getcp(time_in_s,alt_drug_set_index)*10)/10;
alt_result_e = Math.round(getce(time_in_s,alt_drug_set_index)*10)/10;
//document.getElementById("cp_opioid").innerHTML = alt_result;
//document.getElementById("ce_opioid").innerHTML = alt_result_e;
//document.getElementById("inf_opioid").innerHTML = drug_sets[alt_drug_set_index].inf_rate_mls;
//code to target alt drug imminent rate change
if (drug_sets[alt_drug_set_index].historyarray.length>0) {
let nextIndex = drug_sets[alt_drug_set_index].historyarray.findIndex((element)=>element[0]>time_in_s);
if (nextIndex > 0) {
difference = drug_sets[alt_drug_set_index].historyarray[nextIndex][0] - time_in_s;
if (difference < 30) {
if (ringbell2active == 0) {
ringbell2(difference*1000/simspeed);
}
//ding twice to alert to alert alt drug change
if (alert_sound_on == 1) {
if (alert_sound_on == 1) {
if (!alert_sound_2) {
alert_sound_2 = setInterval("alert_sound_object2.play()",3000);
}
}
if (alert_vibrate_on == 1) {
if (!alert_vibrate_2) {
alert_vibrate_2 = setInterval("window.navigator.vibrate(500)",3000);
}
}
}
} else if (difference < 5) {
if ((notificationallowed == 1) && (notificationactive == 1)) {
if (drug_sets[alt_drug_set_index].IB_active == 1) {
tempMessage2 = "Next Bolus: " + drug_sets[alt_drug_set_index].historyarray[nextIndex][2] + drug_sets[alt_drug_set_index].infused_units;
} else {
tempMessage2 = "Infuse at " + Math.round(drug_sets[alt_drug_set_index].historyarray[nextIndex][1]*3600/drug_sets[alt_drug_set_index].infusate_concentration*10)/10 + "ml/h";
}
showNotification(tempMessage2, alt_drug_set_index);
}
} else { // not within 30s window
if (alert_sound_on == 1) {clearInterval(alert_sound_2); alert_sound_2 = null;}
if (alert_vibrate_on == 1) {clearInterval(alert_vibrate_2); alert_vibrate_2 = null;}
}
} else { // to cater for findIndex not found, returns -1, means it is time is past the last of historyarray of alt
if (alert_sound_on == 1) {clearInterval(alert_sound_2); alert_sound_2 = null;}
if (alert_vibrate_on == 1) {clearInterval(alert_vibrate_2); alert_vibrate_2 = null;}
}
} else {
// to account for alt drug may not be CPT/CET; may be manual etc, off notif at this point
if (alert_sound_on == 1) {clearInterval(alert_sound_2); alert_sound_2 = null;}
if (alert_vibrate_on == 1) {clearInterval(alert_vibrate_2); alert_vibrate_2 = null;}
}
}
}
function preview_cpt(x,ind) {
drug_sets[ind].desired = x;
drug_sets[ind].preview_bolus = 0;
drug_sets[ind].cpt_bolus = 0;
drug_sets[ind].preview_rate = 0;
drug_sets[ind].previewhistorytext = "";
max_rate_input = drug_sets[ind].max_rate;
bolus_duration = 0;
if (drug_sets[ind].previewhistoryarray == undefined) drug_sets[ind].previewhistoryarray = new Array();