diff --git a/chromosome_region/requirements.txt b/chromosome_region/requirements.txt
index 12f1a4a3..b215d200 100644
--- a/chromosome_region/requirements.txt
+++ b/chromosome_region/requirements.txt
@@ -36,7 +36,7 @@ multidict==6.0.4
     # via
     #   aiohttp
     #   yarl
-protobuf==4.21.12
+protobuf==4.22.4
     # via grpcio-tools
 redis==4.4.2
     # via chromosome-region (setup.py)