effects of sequence coverage on the estimate

[jianshu93]

Hello mcorr team,

I am wondering for the metagenomic case, whether the coverage of the target genome affected the final c estimate. I can see that the simulation use 5X coverage for the genome. In many real world cases, coverage varies by quite a lot sample by sample. Is there a rule to say what coverage threshold is the best, e.g., >5X?

Thanks for the great tool.

Jianshu