From ee64b51fb957f0f3109cf6aacf63869a6f979c2d Mon Sep 17 00:00:00 2001
From: karolamik13 <karolami@pitt.edu>
Date: Wed, 13 Nov 2024 14:59:56 +0100
Subject: [PATCH] Checks for database_folder exists

---
 prody/proteins/interactions.py | 4 ++++
 1 file changed, 4 insertions(+)

diff --git a/prody/proteins/interactions.py b/prody/proteins/interactions.py
index e5d2050b8..9cc43962a 100644
--- a/prody/proteins/interactions.py
+++ b/prody/proteins/interactions.py
@@ -3404,6 +3404,10 @@ def runFoldseek(pdb_file, chain, **kwargs):
     coverage_threshold = kwargs.pop('coverage_threshold', 0.3)
     tm_threshold = kwargs.pop('tm_threshold', 0.5)    
     
+    full_path = os.path.expanduser(database_folder)
+    if not os.path.exists(full_path.strip('pdb')):
+        raise ValueError('The required database is not found in {0}. Please download it first.'.format(database_folder.strip('pdb')))
+    
     # Define the amino acid conversion function
     def aa_onelet(three_letter_code):
         codes = {