Indel results aggregation

Position results aggregation

Similar to the results aggregation, where we aggregate multiple structural analysis results into aggregated position results, we can further aggregate multiple position results again together. Doing so, we can assign structural features to any set of amino acids.

Indel region aggregation

Position result aggregation can directly performed on regions that are changed by an indel. The exact way how this technique is applied depends on the type of indel. Generally, we have to in-silico mutate the wildtype sequence of the corresponding protein and process the mutant sequence as input to the StructMAn pipeline.

Deletions

For deletions, we aggregate the positions that get removed from the wildtype sequence.

Insertions

For insertions, we aggregate the positions that got inserted into the mutant sequence.

Substitutions

For substitutions, we aggregate both, the deleted positions from the wildtype sequence, and the inserted positions from the mutant sequence.

Flanking region aggregation