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Robyn Ffrancon edited this page Jun 5, 2018
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Welcome to the gramtools wiki!
Gramtools builds a directed acyclical graph (DAG) of genetic variation from a population of genomes. Given sequence data from a haploid individual, alleles on the graph are annotated with coverage information. A personalised reference genome (PRG) for the sample being studied can then be inferred from the annotated graph. The infered PRG is the closest recombinant of genomes in the graph.
Future work will extend functionality to support the following:
- diploid inference
- mixed ploidy inference
- novel variant discovery.