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Feature Request - add seqs_per_slice=1000 when convert to cram #91

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lindaxiang opened this issue Mar 17, 2020 · 0 comments
Open

Feature Request - add seqs_per_slice=1000 when convert to cram #91

lindaxiang opened this issue Mar 17, 2020 · 0 comments
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new-feature Request is a new feature

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@lindaxiang
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Detailed Description

As indicated in wiki: https://wiki.oicr.on.ca/display/icgcargotech/Data+Management+Tasks
The way the CRAM is generated can minimise compute overhead, see samtools, use seqs_per_slice=1000 instead of the default. Increase in file size is negligible, but has a large impact on random access.

Possible Implementation

Should add seqs_per_slice=1000 at
https://github.com/icgc-argo/dna-seq-processing-tools/blob/master/tools/bam-merge-sort-markdup/bam-merge-sort-markdup.py#L62

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