diff --git a/.github/workflows/HDMF_dev.yaml b/.github/workflows/HDMF_dev.yaml
new file mode 100644
index 00000000..51c6ec64
--- /dev/null
+++ b/.github/workflows/HDMF_dev.yaml
@@ -0,0 +1,38 @@
+name: HDMF Dev Branch Compatibility
+
+on: [pull_request, workflow_dispatch]
+
+jobs:
+  check_compatibility:
+    runs-on: ubuntu-latest
+    steps:
+      - name: Cancel non-latest runs
+        uses: styfle/cancel-workflow-action@0.11.0
+        with:
+          all_but_latest: true
+          access_token: ${{ github.token }}
+          
+      - uses: actions/checkout@v4
+      
+      - name: Set up Python 3.11
+        uses: actions/setup-python@v4
+        with:
+          python-version: "3.11"
+
+      - name: Install HDMF_Zarr Requirements
+        run: |
+          python -m pip install -r requirements-dev.txt -r requirements.txt
+          
+      - name: Clone HDMF Dev Branch
+        run: |
+          git clone https://github.com/hdmf-dev/hdmf.git --recurse-submodules
+          cd hdmf
+          python -m pip install -r requirements-dev.txt -r requirements.txt
+          python -m pip install -e .
+
+      - name: Run HDMF_Zarr Tests
+        run:
+          pytest
+          
+      
+