From b4058ab4627c04e9dd13fe67c1f1f561077b6f3f Mon Sep 17 00:00:00 2001 From: Rodrigo V Honorato Date: Wed, 8 May 2024 14:29:06 +0200 Subject: [PATCH] add api golden data --- tests/{api => golden_data}/bestpdb.json | 0 tests/golden_data/ligand.json | 11746 ++++++++++++++++++++++ tests/golden_data/uniprot.json | 6879 +++++++++++++ 3 files changed, 18625 insertions(+) rename tests/{api => golden_data}/bestpdb.json (100%) create mode 100644 tests/golden_data/ligand.json create mode 100644 tests/golden_data/uniprot.json diff --git a/tests/api/bestpdb.json b/tests/golden_data/bestpdb.json similarity index 100% rename from tests/api/bestpdb.json rename to tests/golden_data/bestpdb.json diff --git a/tests/golden_data/ligand.json b/tests/golden_data/ligand.json new file mode 100644 index 0000000..2700b3d --- /dev/null +++ b/tests/golden_data/ligand.json @@ -0,0 +1,11746 @@ +{ + "P07550": { + "sequence": "MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL", + "length": 413, + "dataType": "LIGAND BINDING SITES", + "data": [ + { + "name": "(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol", + "accession": "TIM", + "residues": [ + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 118, + "endIndex": 118, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 199, + "endIndex": 199, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 204, + "endIndex": 204, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 286, + "endIndex": 286, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 308, + "endIndex": 308, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3d4s", "6ps6", "6ps1"] + } + ], + "additionalData": { + "scaffoldId": "c1nsnc1N1CCOCC1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "DB00373", + "numAtoms": 21, + "targetUniProts": ["P08588", "P07550"], + "pdbEntries": ["6ps6", "3d4s", "6ps1"] + } + }, + { + "name": "L-EPINEPHRINE", + "accession": "ALE", + "residues": [ + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo"] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo"] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo"] + } + ], + "additionalData": { + "scaffoldId": "c1ccccc1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "DB00668", + "numAtoms": 13, + "targetUniProts": [ + "P08588", + "P35368", + "P07550", + "P35348", + "P18089", + "P08913" + ], + "pdbEntries": ["4ldo"] + } + }, + { + "name": "SALBUTAMOL", + "accession": "68H", + "residues": [ + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhi", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhi"] + }, + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhi", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhi"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhi", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhi"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhi", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhi"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhi", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhi"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhi", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhi"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhi", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhi"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhi", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhi"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhi", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhi"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhi", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhi"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhi", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhi"] + } + ], + "additionalData": { + "scaffoldId": "c1ccccc1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "DB13139", + "numAtoms": 17, + "targetUniProts": ["P07550"], + "pdbEntries": ["7dhi"] + } + }, + { + "name": "ISOPRENALINE", + "accession": "5FW", + "residues": [ + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhr", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhr"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhr", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhr"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhr", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhr"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhr", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhr"] + }, + { + "startIndex": 118, + "endIndex": 118, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhr", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhr"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhr", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhr"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhr", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhr"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhr", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhr"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7dhr", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7dhr"] + } + ], + "additionalData": { + "scaffoldId": "c1ccccc1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 15, + "targetUniProts": [], + "pdbEntries": ["7dhr"] + } + }, + { + "name": "(2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol", + "accession": "JTZ", + "residues": [ + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8jjo", "entityId": 1, "chainIds": "F" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8jjo", "entityId": 1, "chainIds": "F" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8jjo", "entityId": 1, "chainIds": "F" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjo", "entityId": 1, "chainIds": "F" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 118, + "endIndex": 118, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8jjo", "entityId": 1, "chainIds": "F" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 195, + "endIndex": 195, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 199, + "endIndex": 199, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 200, + "endIndex": 200, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8jjo", "entityId": 1, "chainIds": "F" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 204, + "endIndex": 204, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 286, + "endIndex": 286, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8jjo", "entityId": 1, "chainIds": "F" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8jjo", "entityId": 1, "chainIds": "F" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjo", "entityId": 1, "chainIds": "F" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8jjo", "entityId": 1, "chainIds": "F" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8jjo", "entityId": 1, "chainIds": "F" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6prz", "3nya", "6oba", "8jjo", "6ps2"] + } + ], + "additionalData": { + "scaffoldId": "c1ccccc1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 18, + "targetUniProts": [], + "pdbEntries": ["3nya", "6ps2", "6prz", "8jjo", "6oba"] + } + }, + { + "name": "ethyl 4-({(2S)-2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)-3-methyl-1-benzofuran-2-carboxylate", + "accession": "JSZ", + "residues": [ + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 195, + "endIndex": 195, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 199, + "endIndex": 199, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 200, + "endIndex": 200, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 286, + "endIndex": 286, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 308, + "endIndex": 308, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny9"] + } + ], + "additionalData": { + "scaffoldId": "c1ccc2occc2c1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 24, + "targetUniProts": [], + "pdbEntries": ["3ny9"] + } + }, + { + "name": "1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL", + "accession": "SNP", + "residues": [ + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps5"] + }, + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps5"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps5"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps5"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps5"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps5"] + }, + { + "startIndex": 199, + "endIndex": 199, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps5"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps5"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps5"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps5"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps5"] + } + ], + "additionalData": { + "scaffoldId": "c1ccc2ccccc2c1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 19, + "targetUniProts": [], + "pdbEntries": ["6ps5"] + } + }, + { + "name": "(2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol", + "accession": "CAU", + "residues": [ + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "B" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "B" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "B" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "B" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "B" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 118, + "endIndex": 118, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "B" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 195, + "endIndex": 195, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "B" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 199, + "endIndex": 199, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "B" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 200, + "endIndex": 200, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "B" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 204, + "endIndex": 204, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 286, + "endIndex": 286, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "B" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "B" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 308, + "endIndex": 308, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "B" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4gbr", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "B" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "5d5a", + "5x7d", + "2rh1", + "5d6l", + "6ps0", + "4gbr", + "5jqh", + "5d5b" + ] + } + ], + "additionalData": { + "scaffoldId": "c1ccc2c(c1)[nH]c1ccccc12", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 22, + "targetUniProts": [], + "pdbEntries": [ + "5x7d", + "2rh1", + "5jqh", + "5d5a", + "4gbr", + "5d6l", + "5d5b", + "6ps0" + ] + } + }, + { + "name": "(5R,6R)-6-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol", + "accession": "GJ6", + "residues": [ + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 308, + "endIndex": 308, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["7xk9"] + } + ], + "additionalData": { + "scaffoldId": "c1ccc2c(c1)CCCC2", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 17, + "targetUniProts": [], + "pdbEntries": ["7xk9"] + } + }, + { + "name": "(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol", + "accession": "G1I", + "residues": [ + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8gef", "entityId": 4, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8ggc", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uny", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gec", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggx", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unu", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unn", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh1", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggf", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfy", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gej", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggt", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggm", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8uns", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggl", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unq", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggj", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unm", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggo", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggr", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggv", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gef", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggp", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uno", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggs", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggn", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ged", "entityId": 4, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8gea", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gdz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unp", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gee", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggk", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggw", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggq", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unt", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gga", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geg", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gei", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggu", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unl", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unr", "entityId": 4, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8ggx", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8uo2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gdz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geg", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gef", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggf", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gge", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uno", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unl", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uny", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfy", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggv", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gee", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggn", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggm", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggz", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggl", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggk", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggq", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unn", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8geh", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggc", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggj", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gea", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggs", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unq", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggw", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggp", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gh0", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggt", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggu", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gec", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh1", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggi", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggr", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggo", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unp", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gga", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggy", "entityId": 1, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8unv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geh", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gga", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggr", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggj", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unp", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfy", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gea", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggl", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggp", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gge", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unn", "entityId": 4, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8gh1", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8uo1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gee", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggn", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggk", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggx", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggz", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8geb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unr", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggy", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggw", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unl", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uny", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggi", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gdz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uno", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gec", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gei", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggm", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unt", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uns", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh0", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggu", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ged", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggv", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gej", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggc", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggq", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggf", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unm", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geg", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gef", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggt", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unu", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggs", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unq", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggo", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg2", "entityId": 4, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8ggj", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unm", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gge", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggv", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8geg", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggr", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggp", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggx", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unl", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unp", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gdz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggo", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggm", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggz", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ged", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unr", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggq", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8geb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uno", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggw", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggt", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unt", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gea", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggs", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unq", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggc", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggf", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh0", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggk", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unn", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8gfw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geh", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gec", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gee", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggu", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unu", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggy", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gef", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gei", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uny", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh1", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggl", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggn", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gej", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gga", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uns", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfy", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggi", "entityId": 1, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8uo4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggt", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfy", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggm", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ged", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggl", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggu", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unl", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gdz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggj", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gge", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unt", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gga", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggv", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8uny", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggr", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unq", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggq", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unm", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unn", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unp", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggi", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8unr", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggy", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8uns", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggo", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggw", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gh1", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gee", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh0", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggc", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggk", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unu", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggn", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggs", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggp", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggx", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gea", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uno", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggz", "entityId": 1, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 204, + "endIndex": 204, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8ggf", "entityId": 4, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8gg1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggk", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfy", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gee", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unl", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unq", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggn", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggw", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggj", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggi", "entityId": 1, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8gdz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggo", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gea", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unm", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unp", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uns", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggl", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggm", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unn", "entityId": 4, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8ggq", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ged", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggv", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unn", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggi", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unp", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gef", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gei", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggo", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggk", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unl", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unt", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unr", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggp", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unu", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gee", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggy", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggl", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggj", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uny", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh0", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unm", "entityId": 4, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8gfw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggf", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggt", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggz", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggx", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfy", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unq", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geh", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uno", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geg", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggr", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggn", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggc", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggm", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggu", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gea", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gdz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggw", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8uo0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gga", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uns", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggs", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gec", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo1", "entityId": 4, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8ggk", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggt", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggv", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggi", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh0", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unl", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unn", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ged", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unr", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggn", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unm", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggs", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unq", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unu", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unp", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uns", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gee", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gei", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gec", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggy", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8geg", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uno", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggw", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggu", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggj", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggx", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggr", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggp", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gej", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggz", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unt", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfy", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gdz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggl", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh1", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gea", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gga", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggq", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8uny", "entityId": 4, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8unx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gef", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggo", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggm", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8uo0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge8", "entityId": 4, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8gfw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uny", "entityId": 4, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8ggj", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unt", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unl", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uno", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unu", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh1", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggk", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8uo0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ged", "entityId": 4, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 308, + "endIndex": 308, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8ge2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggn", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggf", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unq", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggc", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggt", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gea", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggr", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unl", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geh", "entityId": 4, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8ge7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggs", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unu", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gdz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gge", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggl", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gh0", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gh1", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gec", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggw", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggu", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggj", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggm", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge5", "entityId": 4, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8unw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unt", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggs", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggk", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggt", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unl", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfy", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gea", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gef", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggw", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unn", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh1", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gee", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unp", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uno", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gej", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gec", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggi", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggn", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggj", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unu", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unr", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8unq", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggp", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8gdz", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uo1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggz", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggv", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggm", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfw", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gfv", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gg0", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggx", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggu", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gg1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geg", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggr", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggo", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gfx", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ged", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggl", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8uns", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh0", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ggq", "entityId": 1, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8ggc", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge5", "entityId": 4, "chainIds": "R" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "8ge4", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggx", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8gee", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gei", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge7", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gef", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gh0", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8unm", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggt", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggy", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8uo3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge9", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge8", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ge1", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geb", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gea", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggw", "entityId": 1, "chainIds": "R" }, + { "pdbId": "8ge2", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geh", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gec", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8geg", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8gga", "entityId": 4, "chainIds": "R" }, + { "pdbId": "8ggb", "entityId": 4, "chainIds": "R" } + ], + "allPDBEntries": [ + "8gg6", + "8gef", + "8gg4", + "8ggi", + "8unr", + "8ge1", + "8ggo", + "8gg5", + "8gg8", + "8gec", + "8geb", + "8gdz", + "8unm", + "8gg0", + "8gh0", + "8ggz", + "8ggb", + "8ggu", + "8gg7", + "8ge7", + "8ge2", + "8ggx", + "8ge6", + "8uo4", + "8gee", + "8gg3", + "8gfx", + "8ge4", + "8ggt", + "8uo2", + "8ggp", + "8ggr", + "8unt", + "8ggq", + "8gg1", + "8unp", + "8ge8", + "7xka", + "8uo1", + "8gfv", + "8gfy", + "8gej", + "8ggc", + "8ggf", + "8unw", + "8ged", + "8gea", + "8gg9", + "8ge9", + "8gfz", + "8ggk", + "8ggy", + "8unn", + "8uny", + "8unz", + "8ge5", + "8unx", + "8ggv", + "8gei", + "8ggn", + "8ggs", + "8unq", + "8gga", + "8uo0", + "8unl", + "8unv", + "8uno", + "8gg2", + "8geh", + "8ggl", + "8ggj", + "8ggm", + "8ge3", + "8geg", + "8uo3", + "8ggw", + "8unu", + "8gge", + "8gh1", + "8gfw", + "8uns" + ] + } + ], + "additionalData": { + "scaffoldId": "c1ccc2c(c1)CCCC2", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 15, + "targetUniProts": [], + "pdbEntries": [ + "8gfv", + "8gfx", + "8gfy", + "8gfw", + "8ggp", + "8gh0", + "8ge7", + "8uny", + "8ggc", + "8ge3", + "8ge1", + "8uo3", + "8unt", + "8unu", + "8ggv", + "8unz", + "8uo1", + "8unx", + "8ggz", + "8gfz", + "8uns", + "8gg8", + "8unn", + "8ge4", + "8ggm", + "8unm", + "8ggq", + "8ge5", + "8gea", + "8ggk", + "8gg0", + "8ggo", + "7xka", + "8gg6", + "8ggn", + "8gec", + "8ge9", + "8gej", + "8ggy", + "8uo0", + "8gg7", + "8ggf", + "8unl", + "8gg2", + "8unv", + "8ggs", + "8uo2", + "8ggl", + "8ggu", + "8ggj", + "8geg", + "8ggw", + "8ge2", + "8ged", + "8uo4", + "8geh", + "8uno", + "8ge8", + "8ggi", + "8ggx", + "8ggt", + "8unw", + "8gei", + "8gdz", + "8gef", + "8geb", + "8gh1", + "8gee", + "8gg4", + "8gg9", + "8ggb", + "8gg5", + "8ggr", + "8unq", + "8gg3", + "8gga", + "8ge6", + "8gge", + "8gg1", + "8unr", + "8unp" + ] + } + }, + { + "name": "(2S,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]butan-2-ol", + "accession": "JRZ", + "residues": [ + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 118, + "endIndex": 118, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 204, + "endIndex": 204, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 308, + "endIndex": 308, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8", "6ps4"] + } + ], + "additionalData": { + "scaffoldId": "c1ccc2c(c1)CCC2", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 20, + "targetUniProts": [], + "pdbEntries": ["6ps4", "3ny8"] + } + }, + { + "name": "(2S)-1-(8H-CARBAZOL-4-YLOXY)-3-[2-(2-METHOXYPHENOXY)ETHYLAMINO]PROPAN-2-OL", + "accession": "CVD", + "residues": [ + { + "startIndex": 93, + "endIndex": 93, + "startCode": "HIS", + "endCode": "HIS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 94, + "endIndex": 94, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 195, + "endIndex": 195, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 199, + "endIndex": 199, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 200, + "endIndex": 200, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 309, + "endIndex": 309, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 313, + "endIndex": 313, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps3"] + } + ], + "additionalData": { + "scaffoldId": "c1ccc(OCCNCCCOc2cccc3[nH]c4ccccc4c23)cc1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 30, + "targetUniProts": [], + "pdbEntries": ["6ps3"] + } + }, + { + "name": "6-bromo-N~2~-phenylquinazoline-2,4-diamine", + "accession": "M3J", + "residues": [ + { + "startIndex": 122, + "endIndex": 122, + "startCode": "GLU", + "endCode": "GLU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6oba"] + }, + { + "startIndex": 125, + "endIndex": 125, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6oba"] + }, + { + "startIndex": 126, + "endIndex": 126, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6oba"] + }, + { + "startIndex": 129, + "endIndex": 129, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6oba"] + }, + { + "startIndex": 206, + "endIndex": 206, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6oba"] + }, + { + "startIndex": 210, + "endIndex": 210, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6oba"] + }, + { + "startIndex": 211, + "endIndex": 211, + "startCode": "PRO", + "endCode": "PRO", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6oba"] + }, + { + "startIndex": 214, + "endIndex": 214, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6oba"] + } + ], + "additionalData": { + "scaffoldId": "c1ccc(Nc2ncc3ccccc3n2)cc1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 19, + "targetUniProts": [], + "pdbEntries": ["6oba"] + } + }, + { + "name": "~{N}-[5-[(1~{R})-2-[[(2~{R})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide", + "accession": "H98", + "residues": [ + { + "startIndex": 93, + "endIndex": 93, + "startCode": "HIS", + "endCode": "HIS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" }, + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" }, + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" }, + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" }, + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" }, + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 191, + "endIndex": 191, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" }, + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 200, + "endIndex": 200, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" }, + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" }, + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 308, + "endIndex": 308, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" }, + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 309, + "endIndex": 309, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jj8", "entityId": 1, "chainIds": "F" }, + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7bz2", "entityId": 5, "chainIds": "R" } + ], + "allPDBEntries": ["7bz2", "8jj8"] + } + ], + "additionalData": { + "scaffoldId": "c1ccc(CCNCCc2ccccc2)cc1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "DB01274", + "numAtoms": 25, + "targetUniProts": ["P07550"], + "pdbEntries": ["7bz2", "8jj8"] + } + }, + { + "name": "4-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(2-sulfanylethoxy)phenyl]ethyl}amino)ethyl]benzene-1,2-diol", + "accession": "35V", + "residues": [ + { + "startIndex": 93, + "endIndex": 93, + "startCode": "HIS", + "endCode": "HIS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 191, + "endIndex": 191, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4qkx"] + } + ], + "additionalData": { + "scaffoldId": "c1ccc(CCNCCc2ccccc2)cc1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 26, + "targetUniProts": [], + "pdbEntries": ["4qkx"] + } + }, + { + "name": "4-[(1R)-1-hydroxy-2-{[1-(4-hydroxyphenyl)-2-methylpropan-2-yl]amino}ethyl]benzene-1,2-diol", + "accession": "XQC", + "residues": [ + { + "startIndex": 93, + "endIndex": 93, + "startCode": "HIS", + "endCode": "HIS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 191, + "endIndex": 191, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 192, + "endIndex": 192, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 308, + "endIndex": 308, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 309, + "endIndex": 309, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldl"] + } + ], + "additionalData": { + "scaffoldId": "c1ccc(CCNCCc2ccccc2)cc1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 23, + "targetUniProts": [], + "pdbEntries": ["4ldl"] + } + }, + { + "name": "salmeterol", + "accession": "K5Y", + "residues": [ + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 191, + "endIndex": 191, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 192, + "endIndex": 192, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 194, + "endIndex": 194, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 296, + "endIndex": 296, + "startCode": "HIS", + "endCode": "HIS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 303, + "endIndex": 303, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 305, + "endIndex": 305, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 308, + "endIndex": 308, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 309, + "endIndex": 309, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + } + ], + "additionalData": { + "scaffoldId": "c1ccc(CCCCOCCCCCCNCCc2ccccc2)cc1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 30, + "targetUniProts": [], + "pdbEntries": ["6mxt"] + } + }, + { + "name": "8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one", + "accession": "ERC", + "residues": [ + { + "startIndex": 90, + "endIndex": 90, + "startCode": "GLY", + "endCode": "GLY", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 93, + "endIndex": 93, + "startCode": "HIS", + "endCode": "HIS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 99, + "endIndex": 99, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 191, + "endIndex": 191, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 192, + "endIndex": 192, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 200, + "endIndex": 200, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 309, + "endIndex": 309, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 313, + "endIndex": 313, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3pds"] + } + ], + "additionalData": { + "scaffoldId": "O=c1ccc2c(CCNCCc3ccccc3)cccc2[nH]1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 31, + "targetUniProts": [], + "pdbEntries": ["3pds"] + } + }, + { + "name": "Olodaterol", + "accession": "DZQ", + "residues": [ + { + "startIndex": 93, + "endIndex": 93, + "startCode": "HIS", + "endCode": "HIS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 191, + "endIndex": 191, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 192, + "endIndex": 192, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 200, + "endIndex": 200, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 308, + "endIndex": 308, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 309, + "endIndex": 309, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "8jjl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8jjl"] + } + ], + "additionalData": { + "scaffoldId": "O=C1COc2c(CCNCCc3ccccc3)cccc2N1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "DB09080", + "numAtoms": 28, + "targetUniProts": ["P07550"], + "pdbEntries": ["8jjl"] + } + }, + { + "name": "8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one", + "accession": "P0G", + "residues": [ + { + "startIndex": 93, + "endIndex": 93, + "startCode": "HIS", + "endCode": "HIS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "R" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 109, + "endIndex": 109, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3sn6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "B" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 110, + "endIndex": 110, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ni3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "B" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 113, + "endIndex": 113, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "B" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "R" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 114, + "endIndex": 114, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "B" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 117, + "endIndex": 117, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ni3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "B" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 191, + "endIndex": 191, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 193, + "endIndex": 193, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "B" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "R" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 200, + "endIndex": 200, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "B" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 203, + "endIndex": 203, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6e67", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "B" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "R" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 207, + "endIndex": 207, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "B" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "R" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 289, + "endIndex": 289, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "B" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "R" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 290, + "endIndex": 290, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "B" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 293, + "endIndex": 293, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3sn6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "B" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 308, + "endIndex": 308, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ni3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "B" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 309, + "endIndex": 309, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3sn6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "R" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "B" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 312, + "endIndex": 312, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3p0g", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3sn6", "entityId": 4, "chainIds": "R" }, + { "pdbId": "6e67", "entityId": 1, "chainIds": "B" }, + { "pdbId": "6ni3", "entityId": 4, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + }, + { + "startIndex": 316, + "endIndex": 316, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3sn6", "3p0g", "6e67", "6ni3", "6n48", "4lde"] + } + ], + "additionalData": { + "scaffoldId": "O=C1COc2c(CCNCCc3ccccc3)cccc2N1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 27, + "targetUniProts": [], + "pdbEntries": ["6ni3", "6n48", "6e67", "4lde", "3p0g", "3sn6"] + } + }, + { + "name": "N-[(3R)-4-(4-tert-butylphenyl)-3-({2-[(4-methoxyphenyl)sulfanyl]-5-[methyl(propan-2-yl)sulfamoyl]benzene-1-carbonyl}amino)butanoyl]glycine", + "accession": "KBY", + "residues": [ + { + "startIndex": 126, + "endIndex": 126, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6n48"] + }, + { + "startIndex": 133, + "endIndex": 133, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6n48"] + }, + { + "startIndex": 137, + "endIndex": 137, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6n48"] + }, + { + "startIndex": 141, + "endIndex": 141, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6n48"] + }, + { + "startIndex": 144, + "endIndex": 144, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6n48"] + }, + { + "startIndex": 145, + "endIndex": 145, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6n48"] + }, + { + "startIndex": 149, + "endIndex": 149, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6n48"] + }, + { + "startIndex": 152, + "endIndex": 152, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6n48"] + }, + { + "startIndex": 153, + "endIndex": 153, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6n48"] + }, + { + "startIndex": 156, + "endIndex": 156, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6n48"] + } + ], + "additionalData": { + "scaffoldId": "O=C(NCCc1ccccc1)c1ccccc1Sc1ccccc1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 46, + "targetUniProts": [], + "pdbEntries": ["6n48"] + } + }, + { + "name": "4-carbamoyl-N-[(2R)-2-cyclohexyl-2-phenylacetyl]-L-phenylalanyl-3-bromo-N-methyl-L-phenylalaninamide", + "accession": "8VS", + "residues": [ + { + "startIndex": 54, + "endIndex": 54, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 57, + "endIndex": 57, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 58, + "endIndex": 58, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 61, + "endIndex": 61, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 63, + "endIndex": 63, + "startCode": "ARG", + "endCode": "ARG", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 64, + "endIndex": 64, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 69, + "endIndex": 69, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 72, + "endIndex": 72, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 270, + "endIndex": 270, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 271, + "endIndex": 271, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 274, + "endIndex": 274, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 275, + "endIndex": 275, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 326, + "endIndex": 326, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 328, + "endIndex": 328, + "startCode": "ARG", + "endCode": "ARG", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 329, + "endIndex": 329, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 331, + "endIndex": 331, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 332, + "endIndex": 332, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 335, + "endIndex": 335, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + } + ], + "additionalData": { + "scaffoldId": "O=C(NCCc1ccccc1)[C@H](Cc1ccccc1)NC(=O)[C@@H](c1ccccc1)C1CCCCC1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 43, + "targetUniProts": [], + "pdbEntries": ["5x7d"] + } + }, + { + "name": "4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID", + "accession": "EPE", + "residues": [ + { + "startIndex": 66, + "endIndex": 66, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 67, + "endIndex": 67, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 68, + "endIndex": 68, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 131, + "endIndex": 131, + "startCode": "ARG", + "endCode": "ARG", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 141, + "endIndex": 141, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 142, + "endIndex": 142, + "startCode": "GLN", + "endCode": "GLN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 143, + "endIndex": 143, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 264, + "endIndex": 264, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 270, + "endIndex": 270, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + }, + { + "startIndex": 273, + "endIndex": 273, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5x7d"] + } + ], + "additionalData": { + "scaffoldId": "C1CNCCN1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 15, + "targetUniProts": [], + "pdbEntries": ["5x7d"] + } + }, + { + "name": "CHOLESTEROL", + "accession": "CLR", + "residues": [ + { + "startIndex": 44, + "endIndex": 44, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 45, + "endIndex": 45, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 48, + "endIndex": 48, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 49, + "endIndex": 49, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 52, + "endIndex": 52, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 53, + "endIndex": 53, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 55, + "endIndex": 55, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "B" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 56, + "endIndex": 56, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 59, + "endIndex": 59, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 70, + "endIndex": 70, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 73, + "endIndex": 73, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 77, + "endIndex": 77, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "B" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 80, + "endIndex": 80, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "B" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 81, + "endIndex": 81, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "B" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 84, + "endIndex": 84, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 85, + "endIndex": 85, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5jqh", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "B" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 108, + "endIndex": 108, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 112, + "endIndex": 112, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 115, + "endIndex": 115, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 151, + "endIndex": 151, + "startCode": "ARG", + "endCode": "ARG", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 154, + "endIndex": 154, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 155, + "endIndex": 155, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 158, + "endIndex": 158, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3nya", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 166, + "endIndex": 166, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6oba", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 339, + "endIndex": 339, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + }, + { + "startIndex": 340, + "endIndex": 340, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps4", + "3nya", + "6ps5", + "3pds", + "3d4s", + "6oba", + "3ny8", + "2rh1", + "5d6l", + "6ps0", + "6ps2", + "5d5a", + "5x7d", + "6ps3", + "6prz", + "6ps6", + "3ny9", + "6ps1", + "5jqh", + "5d5b" + ] + } + ], + "additionalData": { + "scaffoldId": "C1=C2CCCCC2[C@H]2CCC3CCC[C@H]3[C@@H]2C1", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 28, + "targetUniProts": [], + "pdbEntries": [ + "5x7d", + "5d5a", + "6ps2", + "6ps4", + "6ps3", + "3nya", + "6ps5", + "6oba", + "3ny9", + "2rh1", + "5d6l", + "3pds", + "5jqh", + "6ps1", + "3ny8", + "6ps6", + "6prz", + "3d4s", + "5d5b", + "6ps0" + ] + } + }, + { + "name": "TRIETHYLENE GLYCOL", + "accession": "PGE", + "residues": [ + { + "startIndex": 100, + "endIndex": 100, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["3ny8"] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 10, + "targetUniProts": [], + "pdbEntries": ["3ny8"] + } + }, + { + "name": "PALMITIC ACID", + "accession": "PLM", + "residues": [ + { + "startIndex": 339, + "endIndex": 339, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "2rh1", "5d6l", "5d5b"] + }, + { + "startIndex": 341, + "endIndex": 341, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "2rh1", "5d6l", "5d5b"] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 18, + "targetUniProts": [], + "pdbEntries": ["5d6l", "5d5b", "2rh1", "5d5a"] + } + }, + { + "name": "ACETAMIDE", + "accession": "ACM", + "residues": [ + { + "startIndex": 264, + "endIndex": 264, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "5x7d", "2rh1", "5d6l", "5d5b"] + }, + { + "startIndex": 265, + "endIndex": 265, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "5x7d", "2rh1", "5d6l", "5d5b"] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 4, + "targetUniProts": [], + "pdbEntries": ["5x7d", "2rh1", "5d5a", "5d6l", "5d5b"] + } + }, + { + "name": "NICKEL (II) ION", + "accession": "NI", + "residues": [ + { + "startIndex": 107, + "endIndex": 107, + "startCode": "GLU", + "endCode": "GLU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + }, + { + "startIndex": 172, + "endIndex": 172, + "startCode": "HIS", + "endCode": "HIS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6mxt"] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 1, + "targetUniProts": [], + "pdbEntries": ["6mxt"] + } + }, + { + "name": "MAGNESIUM ION", + "accession": "MG", + "residues": [ + { + "startIndex": 103, + "endIndex": 103, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8uo4", "8uo3", "6mxt", "8uo1"] + }, + { + "startIndex": 184, + "endIndex": 184, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8uo4", "8uo3", "6mxt", "8uo1"] + }, + { + "startIndex": 187, + "endIndex": 187, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8uo4", "8uo3", "6mxt", "8uo1"] + }, + { + "startIndex": 190, + "endIndex": 190, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["8uo4", "8uo3", "6mxt", "8uo1"] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 1, + "targetUniProts": [], + "pdbEntries": ["6mxt"] + } + }, + { + "name": "SODIUM ION", + "accession": "NA", + "residues": [ + { + "startIndex": 103, + "endIndex": 103, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4qkx", "4ldl", "7xk9", "7xka", "4lde"] + }, + { + "startIndex": 106, + "endIndex": 106, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4qkx", "4ldl", "7xk9", "7xka", "4lde"] + }, + { + "startIndex": 184, + "endIndex": 184, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" }, + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4qkx", "4ldl", "7xk9", "7xka", "4lde"] + }, + { + "startIndex": 185, + "endIndex": 185, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" }, + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4qkx", "4ldl", "7xk9", "7xka", "4lde"] + }, + { + "startIndex": 187, + "endIndex": 187, + "startCode": "ASN", + "endCode": "ASN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4qkx", "4ldl", "7xk9", "7xka", "4lde"] + }, + { + "startIndex": 190, + "endIndex": 190, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4qkx", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" }, + { "pdbId": "7xka", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" }, + { "pdbId": "7xk9", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4qkx", "4ldl", "7xk9", "7xka", "4lde"] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 1, + "targetUniProts": [], + "pdbEntries": ["4qkx", "7xka", "4lde", "4ldl", "4ldo", "7xk9"] + } + }, + { + "name": "1,4-BUTANEDIOL", + "accession": "BU1", + "residues": [ + { + "startIndex": 215, + "endIndex": 215, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "5x7d", "2rh1", "5d6l", "5d5b"] + }, + { + "startIndex": 216, + "endIndex": 216, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "5x7d", "2rh1", "5d6l", "5d5b"] + }, + { + "startIndex": 223, + "endIndex": 223, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "5x7d", "2rh1", "5d6l", "5d5b"] + }, + { + "startIndex": 226, + "endIndex": 226, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "5x7d", "2rh1", "5d5b"] + }, + { + "startIndex": 227, + "endIndex": 227, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "5x7d", "2rh1", "5d5b"] + }, + { + "startIndex": 264, + "endIndex": 264, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "5x7d", "2rh1", "5d6l", "5d5b"] + }, + { + "startIndex": 269, + "endIndex": 269, + "startCode": "HIS", + "endCode": "HIS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5x7d", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "5x7d", "2rh1", "5d6l", "5d5b"] + }, + { + "startIndex": 279, + "endIndex": 279, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["5d5a", "5x7d", "2rh1", "5d6l", "5d5b"] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 6, + "targetUniProts": [], + "pdbEntries": ["5x7d", "2rh1", "5d5a", "5d6l", "5d5b"] + } + }, + { + "name": "(2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate", + "accession": "1WV", + "residues": [ + { + "startIndex": 36, + "endIndex": 36, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4ldl", "6n48", "4lde"] + }, + { + "startIndex": 39, + "endIndex": 39, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4ldl", "6n48", "4lde"] + }, + { + "startIndex": 40, + "endIndex": 40, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4ldl", "6n48", "4lde"] + }, + { + "startIndex": 43, + "endIndex": 43, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4ldl", "6n48", "4lde"] + }, + { + "startIndex": 94, + "endIndex": 94, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4ldl", "6n48", "4lde"] + }, + { + "startIndex": 309, + "endIndex": 309, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4ldl", "6n48", "4lde"] + }, + { + "startIndex": 310, + "endIndex": 310, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4ldl", "6n48", "4lde"] + }, + { + "startIndex": 313, + "endIndex": 313, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6n48", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4lde", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" }, + { "pdbId": "4ldl", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4ldl", "6n48", "4lde"] + }, + { + "startIndex": 314, + "endIndex": 314, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "4ldo", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["4ldo", "4ldl", "6n48", "4lde"] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 21, + "targetUniProts": [], + "pdbEntries": ["4ldl", "6n48", "4ldo", "4lde"] + } + }, + { + "name": "SULFATE ION", + "accession": "SO4", + "residues": [ + { + "startIndex": 66, + "endIndex": 66, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3kj6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 67, + "endIndex": 67, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3kj6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 68, + "endIndex": 68, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3kj6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 131, + "endIndex": 131, + "startCode": "ARG", + "endCode": "ARG", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 141, + "endIndex": 141, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 142, + "endIndex": 142, + "startCode": "GLN", + "endCode": "GLN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3kj6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 143, + "endIndex": 143, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3kj6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 146, + "endIndex": 146, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 147, + "endIndex": 147, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 264, + "endIndex": 264, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 270, + "endIndex": 270, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 273, + "endIndex": 273, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + }, + { + "startIndex": 328, + "endIndex": 328, + "startCode": "ARG", + "endCode": "ARG", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "2rh1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5a", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3pds", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d6l", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "5d5b", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6ps5", + "3pds", + "2rh1", + "5d6l", + "6ps0", + "3kj6", + "6ps2", + "5d5a", + "6prz", + "6ps3", + "6ps6", + "6ps1", + "5d5b", + "6ps4" + ] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 5, + "targetUniProts": [], + "pdbEntries": [ + "6ps4", + "2rh1", + "3pds", + "6ps1", + "5d5a", + "6ps3", + "6ps2", + "6ps6", + "6prz", + "5d6l", + "5d5b", + "3kj6", + "6ps5", + "6ps0" + ] + } + }, + { + "name": "(2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate", + "accession": "OLB", + "residues": [ + { + "startIndex": 40, + "endIndex": 40, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 41, + "endIndex": 41, + "startCode": "SER", + "endCode": "SER", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 49, + "endIndex": 49, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 52, + "endIndex": 52, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 53, + "endIndex": 53, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 55, + "endIndex": 55, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 59, + "endIndex": 59, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 60, + "endIndex": 60, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 80, + "endIndex": 80, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 85, + "endIndex": 85, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 89, + "endIndex": 89, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 91, + "endIndex": 91, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 95, + "endIndex": 95, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 96, + "endIndex": 96, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 101, + "endIndex": 101, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 105, + "endIndex": 105, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 122, + "endIndex": 122, + "startCode": "GLU", + "endCode": "GLU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 126, + "endIndex": 126, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 129, + "endIndex": 129, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 130, + "endIndex": 130, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 133, + "endIndex": 133, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 144, + "endIndex": 144, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 145, + "endIndex": 145, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 273, + "endIndex": 273, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 276, + "endIndex": 276, + "startCode": "GLY", + "endCode": "GLY", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 281, + "endIndex": 281, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 284, + "endIndex": 284, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 327, + "endIndex": 327, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 336, + "endIndex": 336, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 340, + "endIndex": 340, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + }, + { + "startIndex": 342, + "endIndex": 342, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": ["6ps2"] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 25, + "targetUniProts": [], + "pdbEntries": ["6ps2"] + } + }, + { + "name": "OLEIC ACID", + "accession": "OLA", + "residues": [ + { + "startIndex": 32, + "endIndex": 32, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 36, + "endIndex": 36, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 39, + "endIndex": 39, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 40, + "endIndex": 40, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 43, + "endIndex": 43, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 48, + "endIndex": 48, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 52, + "endIndex": 52, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 56, + "endIndex": 56, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 84, + "endIndex": 84, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 85, + "endIndex": 85, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 89, + "endIndex": 89, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 94, + "endIndex": 94, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 101, + "endIndex": 101, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 105, + "endIndex": 105, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 132, + "endIndex": 132, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 160, + "endIndex": 160, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 163, + "endIndex": 163, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 164, + "endIndex": 164, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 168, + "endIndex": 168, + "startCode": "PRO", + "endCode": "PRO", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 173, + "endIndex": 173, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 198, + "endIndex": 198, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 199, + "endIndex": 199, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 202, + "endIndex": 202, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 206, + "endIndex": 206, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 214, + "endIndex": 214, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 215, + "endIndex": 215, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 216, + "endIndex": 216, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 217, + "endIndex": 217, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 218, + "endIndex": 218, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 219, + "endIndex": 219, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 221, + "endIndex": 221, + "startCode": "ARG", + "endCode": "ARG", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 223, + "endIndex": 223, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 279, + "endIndex": 279, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 283, + "endIndex": 283, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 306, + "endIndex": 306, + "startCode": "GLU", + "endCode": "GLU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 309, + "endIndex": 309, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 310, + "endIndex": 310, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 313, + "endIndex": 313, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 314, + "endIndex": 314, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 317, + "endIndex": 317, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "6ps1", + "6ps2", + "6ps4" + ] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 20, + "targetUniProts": [], + "pdbEntries": [ + "6ps4", + "6ps1", + "3ny8", + "6ps3", + "6ps2", + "6ps6", + "6prz", + "6mxt", + "6ps5", + "6ps0" + ] + } + }, + { + "name": "(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate", + "accession": "OLC", + "residues": [ + { + "startIndex": 33, + "endIndex": 33, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 34, + "endIndex": 34, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 38, + "endIndex": 38, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 45, + "endIndex": 45, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 46, + "endIndex": 46, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 48, + "endIndex": 48, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 49, + "endIndex": 49, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 52, + "endIndex": 52, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 53, + "endIndex": 53, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 55, + "endIndex": 55, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 56, + "endIndex": 56, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 59, + "endIndex": 59, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 60, + "endIndex": 60, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 65, + "endIndex": 65, + "startCode": "GLN", + "endCode": "GLN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 70, + "endIndex": 70, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 73, + "endIndex": 73, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 77, + "endIndex": 77, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 80, + "endIndex": 80, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps1", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 81, + "endIndex": 81, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 89, + "endIndex": 89, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 91, + "endIndex": 91, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 92, + "endIndex": 92, + "startCode": "ALA", + "endCode": "ALA", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 95, + "endIndex": 95, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 96, + "endIndex": 96, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 101, + "endIndex": 101, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 105, + "endIndex": 105, + "startCode": "TRP", + "endCode": "TRP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 118, + "endIndex": 118, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 122, + "endIndex": 122, + "startCode": "GLU", + "endCode": "GLU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 126, + "endIndex": 126, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 129, + "endIndex": 129, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 130, + "endIndex": 130, + "startCode": "ASP", + "endCode": "ASP", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 132, + "endIndex": 132, + "startCode": "TYR", + "endCode": "TYR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 133, + "endIndex": 133, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 144, + "endIndex": 144, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 145, + "endIndex": 145, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 153, + "endIndex": 153, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 156, + "endIndex": 156, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 157, + "endIndex": 157, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 160, + "endIndex": 160, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 206, + "endIndex": 206, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 213, + "endIndex": 213, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 214, + "endIndex": 214, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 216, + "endIndex": 216, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 217, + "endIndex": 217, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 218, + "endIndex": 218, + "startCode": "VAL", + "endCode": "VAL", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 221, + "endIndex": 221, + "startCode": "ARG", + "endCode": "ARG", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 223, + "endIndex": 223, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 269, + "endIndex": 269, + "startCode": "HIS", + "endCode": "HIS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 272, + "endIndex": 272, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 273, + "endIndex": 273, + "startCode": "LYS", + "endCode": "LYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 275, + "endIndex": 275, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 276, + "endIndex": 276, + "startCode": "GLY", + "endCode": "GLY", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 277, + "endIndex": 277, + "startCode": "ILE", + "endCode": "ILE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 279, + "endIndex": 279, + "startCode": "MET", + "endCode": "MET", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6mxt", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 280, + "endIndex": 280, + "startCode": "GLY", + "endCode": "GLY", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 281, + "endIndex": 281, + "startCode": "THR", + "endCode": "THR", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 284, + "endIndex": 284, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps0", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6prz", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 323, + "endIndex": 323, + "startCode": "PRO", + "endCode": "PRO", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 324, + "endIndex": 324, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 327, + "endIndex": 327, + "startCode": "CYS", + "endCode": "CYS", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 336, + "endIndex": 336, + "startCode": "PHE", + "endCode": "PHE", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 337, + "endIndex": 337, + "startCode": "GLN", + "endCode": "GLN", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 338, + "endIndex": 338, + "startCode": "GLU", + "endCode": "GLU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 339, + "endIndex": 339, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "3ny8", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3ny9", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps2", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "3d4s", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 340, + "endIndex": 340, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps6", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps4", "entityId": 1, "chainIds": "A" }, + { "pdbId": "6ps5", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + }, + { + "startIndex": 342, + "endIndex": 342, + "startCode": "LEU", + "endCode": "LEU", + "indexType": "UNIPROT", + "interactingPDBEntries": [ + { "pdbId": "6ps3", "entityId": 1, "chainIds": "A" } + ], + "allPDBEntries": [ + "6prz", + "6ps3", + "6ps5", + "3d4s", + "3ny8", + "6ps6", + "6ps0", + "6mxt", + "3ny9", + "6ps1", + "6ps2", + "6ps4" + ] + } + ], + "additionalData": { + "scaffoldId": "", + "coFactorId": "", + "reactionId": "", + "chemblId": "", + "drugBankId": "", + "numAtoms": 25, + "targetUniProts": [], + "pdbEntries": [ + "6ps4", + "3ny9", + "6ps1", + "3ny8", + "6ps3", + "6ps2", + "6ps6", + "3d4s", + "6prz", + "6mxt", + "6ps5", + "6ps0" + ] + } + } + ] + } +} diff --git a/tests/golden_data/uniprot.json b/tests/golden_data/uniprot.json new file mode 100644 index 0000000..4e60676 --- /dev/null +++ b/tests/golden_data/uniprot.json @@ -0,0 +1,6879 @@ +{ + "accession": "P07550", + "id": "ADRB2_HUMAN", + "proteinExistence": "Evidence at protein level", + "info": { + "type": "Swiss-Prot", + "created": "1988-04-01", + "modified": "2024-03-27", + "version": 250 + }, + "organism": { + "taxonomy": 9606, + "names": [ + { + "type": "scientific", + "value": "Homo sapiens" + }, + { + "type": "common", + "value": "Human" + } + ], + "lineage": [ + "Eukaryota", + "Metazoa", + "Chordata", + "Craniata", + "Vertebrata", + "Euteleostomi", + "Mammalia", + "Eutheria", + "Euarchontoglires", + "Primates", + "Haplorrhini", + "Catarrhini", + "Hominidae", + "Homo" + ] + }, + "secondaryAccession": [ + "B0LPE4", + "B2R7X2", + "O14823", + "O14824", + "O14825", + "O14826", + "Q4JG18", + "Q53GA6", + "Q6GMT4", + "Q6P4D8", + "Q8NEQ9", + "Q96EC3", + "Q9UCZ0", + "Q9UCZ1", + "Q9UCZ2", + "Q9UCZ3", + "Q9UH95", + "Q9UHA1", + "Q9UMZ5" + ], + "protein": { + "recommendedName": { + "fullName": { + "value": "Beta-2 adrenergic receptor" + } + }, + "alternativeName": [ + { + "fullName": { + "value": "Beta-2 adrenoreceptor" + }, + "shortName": [ + { + "value": "Beta-2 adrenoceptor" + } + ] + } + ] + }, + "gene": [ + { + "name": { + "value": "ADRB2" + }, + "synonyms": [ + { + "value": "ADRB2R" + }, + { + "value": "B2AR" + } + ] + } + ], + "comments": [ + { + "type": "FUNCTION", + "text": [ + { + "value": "Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "2831218", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/2831218", + "alternativeUrl": "https://europepmc.org/abstract/MED/2831218" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "7915137", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/7915137", + "alternativeUrl": "https://europepmc.org/abstract/MED/7915137" + } + } + ] + } + ] + }, + { + "type": "SUBUNIT", + "text": [ + { + "value": "Binds NHERF1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (PubMed:9924018). Interacts with USP20 and USP33 (PubMed:19424180, PubMed:23166351). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750). Interacts with ARRDC3 (PubMed:20559325, PubMed:25220262). Interacts with NEDD4 (PubMed:23166351). Interacts with MARCHF2 (PubMed:23166351)", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "10499588", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/10499588", + "alternativeUrl": "https://europepmc.org/abstract/MED/10499588" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "12142540", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/12142540", + "alternativeUrl": "https://europepmc.org/abstract/MED/12142540" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "17952055", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/17952055", + "alternativeUrl": "https://europepmc.org/abstract/MED/17952055" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "17962520", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/17962520", + "alternativeUrl": "https://europepmc.org/abstract/MED/17962520" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "18547522", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/18547522", + "alternativeUrl": "https://europepmc.org/abstract/MED/18547522" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19424180", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19424180", + "alternativeUrl": "https://europepmc.org/abstract/MED/19424180" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19584355", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19584355", + "alternativeUrl": "https://europepmc.org/abstract/MED/19584355" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20559325", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20559325", + "alternativeUrl": "https://europepmc.org/abstract/MED/20559325" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20733053", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20733053", + "alternativeUrl": "https://europepmc.org/abstract/MED/20733053" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "21602791", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/21602791", + "alternativeUrl": "https://europepmc.org/abstract/MED/21602791" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "23166351", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/23166351", + "alternativeUrl": "https://europepmc.org/abstract/MED/23166351" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "24405750", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/24405750", + "alternativeUrl": "https://europepmc.org/abstract/MED/24405750" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "25220262", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/25220262", + "alternativeUrl": "https://europepmc.org/abstract/MED/25220262" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "7822302", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/7822302", + "alternativeUrl": "https://europepmc.org/abstract/MED/7822302" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "9388255", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/9388255", + "alternativeUrl": "https://europepmc.org/abstract/MED/9388255" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "9924018", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/9924018", + "alternativeUrl": "https://europepmc.org/abstract/MED/9924018" + } + } + ] + } + ] + }, + { + "type": "INTERACTION", + "interactions": [ + { + "accession1": "P07550", + "accession2": "P30542", + "gene": "ADORA1", + "interactor1": "EBI-491169", + "interactor2": "EBI-2903663", + "organismDiffer": false, + "experiments": 5 + }, + { + "accession1": "P07550", + "accession2": "P07550", + "gene": "ADRB2", + "interactor1": "EBI-491169", + "interactor2": "EBI-491169", + "organismDiffer": false, + "experiments": 4 + }, + { + "accession1": "P07550", + "accession2": "P32121", + "gene": "ARRB2", + "interactor1": "EBI-491169", + "interactor2": "EBI-714559", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q96B67", + "gene": "ARRDC3", + "interactor1": "EBI-491169", + "interactor2": "EBI-2875665", + "organismDiffer": false, + "experiments": 6 + }, + { + "accession1": "P07550", + "accession2": "Q9UII2", + "gene": "ATP5IF1", + "interactor1": "EBI-491169", + "interactor2": "EBI-718459", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q9ULD4-2", + "gene": "BRPF3", + "interactor1": "EBI-491169", + "interactor2": "EBI-23662416", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q9NSI6-4", + "gene": "BRWD1", + "interactor1": "EBI-491169", + "interactor2": "EBI-10693038", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q5M9N0-2", + "gene": "CCDC158", + "interactor1": "EBI-491169", + "interactor2": "EBI-21796846", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "A0AVK6", + "gene": "E2F8", + "interactor1": "EBI-491169", + "interactor2": "EBI-7779316", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q658K8", + "gene": "EEF1DP3", + "interactor1": "EBI-491169", + "interactor2": "EBI-10248874", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "O00472", + "gene": "ELL2", + "interactor1": "EBI-491169", + "interactor2": "EBI-395274", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q15910-2", + "gene": "EZH2", + "interactor1": "EBI-491169", + "interactor2": "EBI-10699473", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q15486", + "gene": "GUSBP1", + "interactor1": "EBI-491169", + "interactor2": "EBI-712457", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "P61978", + "gene": "HNRNPK", + "interactor1": "EBI-491169", + "interactor2": "EBI-304185", + "organismDiffer": false, + "experiments": 2 + }, + { + "accession1": "P07550", + "accession2": "Q5TCQ9", + "gene": "MAGI3", + "interactor1": "EBI-491169", + "interactor2": "EBI-310506", + "organismDiffer": false, + "experiments": 9 + }, + { + "accession1": "P07550", + "accession2": "Q99685", + "gene": "MGLL", + "interactor1": "EBI-491169", + "interactor2": "EBI-721306", + "organismDiffer": false, + "experiments": 2 + }, + { + "accession1": "P07550", + "accession2": "O14745", + "gene": "NHERF1", + "interactor1": "EBI-491169", + "interactor2": "EBI-349787", + "organismDiffer": false, + "experiments": 6 + }, + { + "accession1": "P07550", + "accession2": "Q9NR21-5", + "gene": "PARP11", + "interactor1": "EBI-491169", + "interactor2": "EBI-17159452", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q8WVD3", + "gene": "RNF138", + "interactor1": "EBI-491169", + "interactor2": "EBI-749039", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q9H0X6", + "gene": "RNF208", + "interactor1": "EBI-491169", + "interactor2": "EBI-751555", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q13573", + "gene": "SNW1", + "interactor1": "EBI-491169", + "interactor2": "EBI-632715", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "P12931", + "gene": "SRC", + "interactor1": "EBI-491169", + "interactor2": "EBI-621482", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q5T0J7-2", + "gene": "TEX35", + "interactor1": "EBI-491169", + "interactor2": "EBI-12833746", + "organismDiffer": false, + "experiments": 3 + }, + { + "accession1": "P07550", + "accession2": "Q8N0U2", + "gene": "TMEM61", + "interactor1": "EBI-491169", + "interactor2": "EBI-25830583", + "organismDiffer": false, + "experiments": 3 + } + ] + }, + { + "type": "SUBCELLULAR_LOCATION", + "locations": [ + { + "location": { + "value": "Cell membrane", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19584355", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19584355", + "alternativeUrl": "https://europepmc.org/abstract/MED/19584355" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20559325", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20559325", + "alternativeUrl": "https://europepmc.org/abstract/MED/20559325" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "23166351", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/23166351", + "alternativeUrl": "https://europepmc.org/abstract/MED/23166351" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "25220262", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/25220262", + "alternativeUrl": "https://europepmc.org/abstract/MED/25220262" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "2831218", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/2831218", + "alternativeUrl": "https://europepmc.org/abstract/MED/2831218" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "7915137", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/7915137", + "alternativeUrl": "https://europepmc.org/abstract/MED/7915137" + } + } + ] + }, + "topology": { + "value": "Multi-pass membrane protein", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19584355", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19584355", + "alternativeUrl": "https://europepmc.org/abstract/MED/19584355" + } + } + ] + } + }, + { + "location": { + "value": "Early endosome", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20559325", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20559325", + "alternativeUrl": "https://europepmc.org/abstract/MED/20559325" + } + } + ] + } + }, + { + "location": { + "value": "Golgi apparatus", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "27481942", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/27481942", + "alternativeUrl": "https://europepmc.org/abstract/MED/27481942" + } + } + ] + } + } + ], + "text": [ + { + "value": "Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942)", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19584355", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19584355", + "alternativeUrl": "https://europepmc.org/abstract/MED/19584355" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20559325", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20559325", + "alternativeUrl": "https://europepmc.org/abstract/MED/20559325" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "27481942", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/27481942", + "alternativeUrl": "https://europepmc.org/abstract/MED/27481942" + } + } + ] + } + ] + }, + { + "type": "PTM", + "text": [ + { + "value": "Palmitoylated (PubMed:2540197, PubMed:11146000, PubMed:27481942, PubMed:17962520, PubMed:18547522). Mainly palmitoylated at Cys-341 (PubMed:2540197, PubMed:17962520, PubMed:18547522). Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (PubMed:11146000). Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi (PubMed:27481942). Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor (PubMed:27481942). Could be depalmitoylated by LYPLA1 at the plasma membrane (PubMed:27481942)", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "11146000", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/11146000", + "alternativeUrl": "https://europepmc.org/abstract/MED/11146000" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "17962520", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/17962520", + "alternativeUrl": "https://europepmc.org/abstract/MED/17962520" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "18547522", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/18547522", + "alternativeUrl": "https://europepmc.org/abstract/MED/18547522" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "2540197", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/2540197", + "alternativeUrl": "https://europepmc.org/abstract/MED/2540197" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "27481942", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/27481942", + "alternativeUrl": "https://europepmc.org/abstract/MED/27481942" + } + } + ] + } + ] + }, + { + "type": "PTM", + "text": [ + { + "value": "Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK" + } + ] + }, + { + "type": "PTM", + "text": [ + { + "value": "Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "8521811", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/8521811", + "alternativeUrl": "https://europepmc.org/abstract/MED/8521811" + } + } + ] + } + ] + }, + { + "type": "PTM", + "text": [ + { + "value": "Polyubiquitinated (PubMed:23166351). Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation (PubMed:19424180, PubMed:20559325, PubMed:23166351). Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19424180", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19424180", + "alternativeUrl": "https://europepmc.org/abstract/MED/19424180" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20559325", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20559325", + "alternativeUrl": "https://europepmc.org/abstract/MED/20559325" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "23166351", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/23166351", + "alternativeUrl": "https://europepmc.org/abstract/MED/23166351" + } + } + ] + } + ] + }, + { + "type": "PTM", + "text": [ + { + "value": "Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19424180", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19424180", + "alternativeUrl": "https://europepmc.org/abstract/MED/19424180" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19584355", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19584355", + "alternativeUrl": "https://europepmc.org/abstract/MED/19584355" + } + } + ] + } + ] + }, + { + "type": "POLYMORPHISM", + "text": [ + { + "value": "The Gly-16 allele is overrepresented in individuals affected by nocturnal asthma as compared to controls, and appears to be an important genetic factor in the expression of this asthmatic phenotype" + } + ] + }, + { + "type": "SIMILARITY", + "text": [ + { + "value": "Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily", + "evidences": [ + { + "code": "ECO:0000255", + "source": { + "name": "PROSITE-ProRule", + "id": "PRU00521", + "url": "https://prosite.expasy.org/unirule/PRU00521" + } + } + ] + } + ] + }, + { + "type": "SEQUENCE_CAUTION", + "conflictType": "ERRONEOUS_INITIATION", + "sequence": "BAD96745.1", + "text": "Extended N-terminus.", + "evidences": [ + { + "code": "ECO:0000305" + } + ] + }, + { + "type": "WEBRESOURCE", + "name": "SeattleSNPs", + "url": "http://pga.gs.washington.edu/data/adrb2/" + } + ], + "features": [ + { + "type": "CHAIN", + "category": "MOLECULE_PROCESSING", + "ftId": "PRO_0000069130", + "description": "Beta-2 adrenergic receptor", + "begin": "1", + "end": "413", + "molecule": "" + }, + { + "type": "TOPO_DOM", + "category": "TOPOLOGY", + "description": "Extracellular", + "begin": "1", + "end": "34", + "molecule": "" + }, + { + "type": "TRANSMEM", + "category": "TOPOLOGY", + "description": "Helical; Name=1", + "begin": "35", + "end": "58", + "molecule": "" + }, + { + "type": "TOPO_DOM", + "category": "TOPOLOGY", + "description": "Cytoplasmic", + "begin": "59", + "end": "71", + "molecule": "" + }, + { + "type": "TRANSMEM", + "category": "TOPOLOGY", + "description": "Helical; Name=2", + "begin": "72", + "end": "95", + "molecule": "" + }, + { + "type": "TOPO_DOM", + "category": "TOPOLOGY", + "description": "Extracellular", + "begin": "96", + "end": "106", + "molecule": "" + }, + { + "type": "TRANSMEM", + "category": "TOPOLOGY", + "description": "Helical; Name=3", + "begin": "107", + "end": "129", + "molecule": "" + }, + { + "type": "TOPO_DOM", + "category": "TOPOLOGY", + "description": "Cytoplasmic", + "begin": "130", + "end": "150", + "molecule": "" + }, + { + "type": "TRANSMEM", + "category": "TOPOLOGY", + "description": "Helical; Name=4", + "begin": "151", + "end": "174", + "molecule": "" + }, + { + "type": "TOPO_DOM", + "category": "TOPOLOGY", + "description": "Extracellular", + "begin": "175", + "end": "196", + "molecule": "" + }, + { + "type": "TRANSMEM", + "category": "TOPOLOGY", + "description": "Helical; Name=5", + "begin": "197", + "end": "220", + "molecule": "" + }, + { + "type": "TOPO_DOM", + "category": "TOPOLOGY", + "description": "Cytoplasmic", + "begin": "221", + "end": "274", + "molecule": "" + }, + { + "type": "TRANSMEM", + "category": "TOPOLOGY", + "description": "Helical; Name=6", + "begin": "275", + "end": "298", + "molecule": "" + }, + { + "type": "TOPO_DOM", + "category": "TOPOLOGY", + "description": "Extracellular", + "begin": "299", + "end": "305", + "molecule": "" + }, + { + "type": "TRANSMEM", + "category": "TOPOLOGY", + "description": "Helical; Name=7", + "begin": "306", + "end": "329", + "molecule": "" + }, + { + "type": "TOPO_DOM", + "category": "TOPOLOGY", + "description": "Cytoplasmic", + "begin": "330", + "end": "413", + "molecule": "" + }, + { + "type": "REGION", + "category": "DOMAINS_AND_SITES", + "description": "Disordered", + "begin": "392", + "end": "413", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000256", + "source": { + "name": "SAM", + "id": "MobiDB-lite", + "url": "https://www.uniprot.org/help/sam" + } + } + ] + }, + { + "type": "MOTIF", + "category": "DOMAINS_AND_SITES", + "description": "PDZ-binding", + "begin": "410", + "end": "413", + "molecule": "" + }, + { + "type": "COMPBIAS", + "category": "SEQUENCE_INFORMATION", + "description": "Polar residues", + "begin": "394", + "end": "413", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000256", + "source": { + "name": "SAM", + "id": "MobiDB-lite", + "url": "https://www.uniprot.org/help/sam" + } + } + ] + }, + { + "type": "BINDING", + "category": "DOMAINS_AND_SITES", + "description": "", + "begin": "113", + "end": "113", + "molecule": "", + "ligand": { + "name": "(S)-carazolol", + "dbReference": { + "name": "ChEBI", + "id": "CHEBI:188146" + }, + "note": "inverse agonist" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "17952055", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/17952055", + "alternativeUrl": "https://europepmc.org/abstract/MED/17952055" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "17962520", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/17962520", + "alternativeUrl": "https://europepmc.org/abstract/MED/17962520" + } + }, + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "BINDING", + "category": "DOMAINS_AND_SITES", + "description": "", + "begin": "113", + "end": "113", + "molecule": "", + "ligand": { + "name": "(S)-timolol", + "dbReference": { + "name": "ChEBI", + "id": "CHEBI:188157" + }, + "note": "inverse agonist" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "18547522", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/18547522", + "alternativeUrl": "https://europepmc.org/abstract/MED/18547522" + } + }, + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "3D4S", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/3D4S" + } + } + ] + }, + { + "type": "BINDING", + "category": "DOMAINS_AND_SITES", + "description": "", + "begin": "118", + "end": "118", + "molecule": "", + "ligand": { + "name": "(S)-timolol", + "dbReference": { + "name": "ChEBI", + "id": "CHEBI:188157" + }, + "note": "inverse agonist" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "18547522", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/18547522", + "alternativeUrl": "https://europepmc.org/abstract/MED/18547522" + } + }, + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "3D4S", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/3D4S" + } + } + ] + }, + { + "type": "BINDING", + "category": "DOMAINS_AND_SITES", + "description": "", + "begin": "203", + "end": "203", + "molecule": "", + "ligand": { + "name": "(S)-carazolol", + "dbReference": { + "name": "ChEBI", + "id": "CHEBI:188146" + }, + "note": "inverse agonist" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "17952055", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/17952055", + "alternativeUrl": "https://europepmc.org/abstract/MED/17952055" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "17962520", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/17962520", + "alternativeUrl": "https://europepmc.org/abstract/MED/17962520" + } + }, + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "BINDING", + "category": "DOMAINS_AND_SITES", + "description": "", + "begin": "293", + "end": "293", + "molecule": "", + "ligand": { + "name": "(S)-timolol", + "dbReference": { + "name": "ChEBI", + "id": "CHEBI:188157" + }, + "note": "inverse agonist" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "18547522", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/18547522", + "alternativeUrl": "https://europepmc.org/abstract/MED/18547522" + } + }, + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "3D4S", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/3D4S" + } + } + ] + }, + { + "type": "BINDING", + "category": "DOMAINS_AND_SITES", + "description": "", + "begin": "312", + "end": "312", + "molecule": "", + "ligand": { + "name": "(S)-carazolol", + "dbReference": { + "name": "ChEBI", + "id": "CHEBI:188146" + }, + "note": "inverse agonist" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "17952055", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/17952055", + "alternativeUrl": "https://europepmc.org/abstract/MED/17952055" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "17962520", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/17962520", + "alternativeUrl": "https://europepmc.org/abstract/MED/17962520" + } + }, + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "BINDING", + "category": "DOMAINS_AND_SITES", + "description": "", + "begin": "312", + "end": "312", + "molecule": "", + "ligand": { + "name": "(S)-timolol", + "dbReference": { + "name": "ChEBI", + "id": "CHEBI:188157" + }, + "note": "inverse agonist" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "18547522", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/18547522", + "alternativeUrl": "https://europepmc.org/abstract/MED/18547522" + } + }, + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "3D4S", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/3D4S" + } + } + ] + }, + { + "type": "BINDING", + "category": "DOMAINS_AND_SITES", + "description": "", + "begin": "316", + "end": "316", + "molecule": "", + "ligand": { + "name": "(S)-timolol", + "dbReference": { + "name": "ChEBI", + "id": "CHEBI:188157" + }, + "note": "inverse agonist" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "18547522", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/18547522", + "alternativeUrl": "https://europepmc.org/abstract/MED/18547522" + } + }, + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "3D4S", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/3D4S" + } + } + ] + }, + { + "type": "MOD_RES", + "category": "PTM", + "description": "Phosphotyrosine", + "begin": "141", + "end": "141", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "8521811", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/8521811", + "alternativeUrl": "https://europepmc.org/abstract/MED/8521811" + } + } + ] + }, + { + "type": "MOD_RES", + "category": "PTM", + "description": "Phosphoserine", + "begin": "246", + "end": "246", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007744", + "source": { + "name": "PubMed", + "id": "17525332", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/17525332", + "alternativeUrl": "https://europepmc.org/abstract/MED/17525332" + } + } + ] + }, + { + "type": "MOD_RES", + "category": "PTM", + "description": "Phosphoserine; by PKA", + "begin": "261", + "end": "261", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000255" + } + ] + }, + { + "type": "MOD_RES", + "category": "PTM", + "description": "Phosphoserine; by PKA", + "begin": "262", + "end": "262", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000255" + } + ] + }, + { + "type": "MOD_RES", + "category": "PTM", + "description": "Phosphoserine; by PKA", + "begin": "345", + "end": "345", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "11146000", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/11146000", + "alternativeUrl": "https://europepmc.org/abstract/MED/11146000" + } + } + ] + }, + { + "type": "MOD_RES", + "category": "PTM", + "description": "Phosphoserine; by PKA", + "begin": "346", + "end": "346", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "11146000", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/11146000", + "alternativeUrl": "https://europepmc.org/abstract/MED/11146000" + } + } + ] + }, + { + "type": "MOD_RES", + "category": "PTM", + "description": "Phosphoserine; by BARK", + "begin": "355", + "end": "355", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000305" + } + ] + }, + { + "type": "MOD_RES", + "category": "PTM", + "description": "Phosphoserine; by BARK", + "begin": "356", + "end": "356", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000305" + } + ] + }, + { + "type": "MOD_RES", + "category": "PTM", + "description": "4-hydroxyproline", + "begin": "382", + "end": "382", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19584355", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19584355", + "alternativeUrl": "https://europepmc.org/abstract/MED/19584355" + } + } + ] + }, + { + "type": "MOD_RES", + "category": "PTM", + "description": "4-hydroxyproline", + "begin": "395", + "end": "395", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19584355", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19584355", + "alternativeUrl": "https://europepmc.org/abstract/MED/19584355" + } + } + ] + }, + { + "type": "LIPID", + "category": "PTM", + "description": "S-palmitoyl cysteine", + "begin": "265", + "end": "265", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "27481942", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/27481942", + "alternativeUrl": "https://europepmc.org/abstract/MED/27481942" + } + } + ] + }, + { + "type": "LIPID", + "category": "PTM", + "description": "S-palmitoyl cysteine", + "begin": "341", + "end": "341", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "17962520", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/17962520", + "alternativeUrl": "https://europepmc.org/abstract/MED/17962520" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "18547522", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/18547522", + "alternativeUrl": "https://europepmc.org/abstract/MED/18547522" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "2540197", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/2540197", + "alternativeUrl": "https://europepmc.org/abstract/MED/2540197" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "27481942", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/27481942", + "alternativeUrl": "https://europepmc.org/abstract/MED/27481942" + } + } + ] + }, + { + "type": "CARBOHYD", + "category": "PTM", + "ftId": "", + "description": "N-linked (GlcNAc...) asparagine", + "begin": "6", + "end": "6", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000305" + } + ] + }, + { + "type": "CARBOHYD", + "category": "PTM", + "ftId": "", + "description": "N-linked (GlcNAc...) asparagine", + "begin": "15", + "end": "15", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000305" + } + ] + }, + { + "type": "DISULFID", + "category": "PTM", + "description": "", + "begin": "106", + "end": "191", + "molecule": "" + }, + { + "type": "DISULFID", + "category": "PTM", + "description": "", + "begin": "184", + "end": "190", + "molecule": "" + }, + { + "type": "VARIANT", + "category": "VARIANTS", + "ftId": "VAR_049373", + "description": "in dbSNP:rs33973603", + "alternativeSequence": "S", + "begin": "15", + "end": "15", + "molecule": "" + }, + { + "type": "VARIANT", + "category": "VARIANTS", + "ftId": "VAR_003452", + "description": "in dbSNP:rs1042713", + "alternativeSequence": "R", + "begin": "16", + "end": "16", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "15489334", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/15489334", + "alternativeUrl": "https://europepmc.org/abstract/MED/15489334" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "3025863", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/3025863", + "alternativeUrl": "https://europepmc.org/abstract/MED/3025863" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "3033609", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/3033609", + "alternativeUrl": "https://europepmc.org/abstract/MED/3033609" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "3034889", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/3034889", + "alternativeUrl": "https://europepmc.org/abstract/MED/3034889" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "7706471", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/7706471", + "alternativeUrl": "https://europepmc.org/abstract/MED/7706471" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "7915137", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/7915137", + "alternativeUrl": "https://europepmc.org/abstract/MED/7915137" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "8383511", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/8383511", + "alternativeUrl": "https://europepmc.org/abstract/MED/8383511" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "Citation", + "id": "Ref.8", + "url": "https://www.uniprot.org/uniprot/P07550#ref8" + } + } + ] + }, + { + "type": "VARIANT", + "category": "VARIANTS", + "ftId": "VAR_003453", + "description": "in dbSNP:rs1042714", + "alternativeSequence": "Q", + "begin": "27", + "end": "27", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "11246467", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/11246467", + "alternativeUrl": "https://europepmc.org/abstract/MED/11246467" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "15489334", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/15489334", + "alternativeUrl": "https://europepmc.org/abstract/MED/15489334" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "2823249", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/2823249", + "alternativeUrl": "https://europepmc.org/abstract/MED/2823249" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "3025863", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/3025863", + "alternativeUrl": "https://europepmc.org/abstract/MED/3025863" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "3026848", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/3026848", + "alternativeUrl": "https://europepmc.org/abstract/MED/3026848" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "3033609", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/3033609", + "alternativeUrl": "https://europepmc.org/abstract/MED/3033609" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "3034889", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/3034889", + "alternativeUrl": "https://europepmc.org/abstract/MED/3034889" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "7915137", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/7915137", + "alternativeUrl": "https://europepmc.org/abstract/MED/7915137" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "8383511", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/8383511", + "alternativeUrl": "https://europepmc.org/abstract/MED/8383511" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "Citation", + "id": "Ref.10", + "url": "https://www.uniprot.org/uniprot/P07550#ref10" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "Citation", + "id": "Ref.11", + "url": "https://www.uniprot.org/uniprot/P07550#ref11" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "Citation", + "id": "Ref.12", + "url": "https://www.uniprot.org/uniprot/P07550#ref12" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "Citation", + "id": "Ref.8", + "url": "https://www.uniprot.org/uniprot/P07550#ref8" + } + } + ] + }, + { + "type": "VARIANT", + "category": "VARIANTS", + "ftId": "VAR_003454", + "description": "in dbSNP:rs990810566", + "alternativeSequence": "M", + "begin": "34", + "end": "34", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "8383511", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/8383511", + "alternativeUrl": "https://europepmc.org/abstract/MED/8383511" + } + } + ] + }, + { + "type": "VARIANT", + "category": "VARIANTS", + "ftId": "VAR_009125", + "description": "", + "alternativeSequence": "F", + "begin": "159", + "end": "159", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "11246467", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/11246467", + "alternativeUrl": "https://europepmc.org/abstract/MED/11246467" + } + } + ] + }, + { + "type": "VARIANT", + "category": "VARIANTS", + "ftId": "VAR_009124", + "description": "", + "alternativeSequence": "L", + "begin": "159", + "end": "159", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "11246467", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/11246467", + "alternativeUrl": "https://europepmc.org/abstract/MED/11246467" + } + } + ] + }, + { + "type": "VARIANT", + "category": "VARIANTS", + "ftId": "VAR_003455", + "description": "in dbSNP:rs1800888", + "alternativeSequence": "I", + "begin": "164", + "end": "164", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "8383511", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/8383511", + "alternativeUrl": "https://europepmc.org/abstract/MED/8383511" + } + } + ] + }, + { + "type": "VARIANT", + "category": "VARIANTS", + "ftId": "VAR_025101", + "description": "in dbSNP:rs3729943", + "alternativeSequence": "C", + "begin": "220", + "end": "220", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "Citation", + "id": "Ref.11", + "url": "https://www.uniprot.org/uniprot/P07550#ref11" + } + } + ] + }, + { + "type": "VARIANT", + "category": "VARIANTS", + "ftId": "VAR_009394", + "description": "in dbSNP:rs771585355", + "alternativeSequence": "R", + "begin": "375", + "end": "375", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "11246467", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/11246467", + "alternativeUrl": "https://europepmc.org/abstract/MED/11246467" + } + } + ] + }, + { + "type": "MUTAGEN", + "category": "MUTAGENESIS", + "description": "Affects binding of catecholamines, and produces an uncoupling between the receptor and stimulatory G proteins.", + "alternativeSequence": "N", + "begin": "79", + "end": "79", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "2831218", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/2831218", + "alternativeUrl": "https://europepmc.org/abstract/MED/2831218" + } + } + ] + }, + { + "type": "MUTAGEN", + "category": "MUTAGENESIS", + "description": "Abolishes insulin-induced tyrosine phosphorylation and insulin-induced receptor supersensitization.", + "alternativeSequence": "F", + "begin": "141", + "end": "141", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "8521811", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/8521811", + "alternativeUrl": "https://europepmc.org/abstract/MED/8521811" + } + } + ] + }, + { + "type": "MUTAGEN", + "category": "MUTAGENESIS", + "description": "Loss of ligand-induced palmitoylation.", + "alternativeSequence": "A", + "begin": "265", + "end": "265", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "27481942", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/27481942", + "alternativeUrl": "https://europepmc.org/abstract/MED/27481942" + } + } + ] + }, + { + "type": "MUTAGEN", + "category": "MUTAGENESIS", + "description": "Loss of basal palmitoylation.", + "alternativeSequence": "A", + "begin": "341", + "end": "341", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "27481942", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/27481942", + "alternativeUrl": "https://europepmc.org/abstract/MED/27481942" + } + } + ] + }, + { + "type": "MUTAGEN", + "category": "MUTAGENESIS", + "description": "Uncoupled receptor.", + "alternativeSequence": "G", + "begin": "341", + "end": "341", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "2540197", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/2540197", + "alternativeUrl": "https://europepmc.org/abstract/MED/2540197" + } + } + ] + }, + { + "type": "MUTAGEN", + "category": "MUTAGENESIS", + "description": "Delayed agonist-promoted desensitization.", + "alternativeSequence": "AA", + "begin": "345", + "end": "346", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "11146000", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/11146000", + "alternativeUrl": "https://europepmc.org/abstract/MED/11146000" + } + } + ] + }, + { + "type": "MUTAGEN", + "category": "MUTAGENESIS", + "description": "Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization.", + "alternativeSequence": "A", + "begin": "350", + "end": "350", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "8521811", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/8521811", + "alternativeUrl": "https://europepmc.org/abstract/MED/8521811" + } + } + ] + }, + { + "type": "MUTAGEN", + "category": "MUTAGENESIS", + "description": "Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization.", + "alternativeSequence": "A", + "begin": "354", + "end": "354", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "8521811", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/8521811", + "alternativeUrl": "https://europepmc.org/abstract/MED/8521811" + } + } + ] + }, + { + "type": "MUTAGEN", + "category": "MUTAGENESIS", + "description": "Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization.", + "alternativeSequence": "F", + "begin": "366", + "end": "366", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "8521811", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/8521811", + "alternativeUrl": "https://europepmc.org/abstract/MED/8521811" + } + } + ] + }, + { + "type": "CONFLICT", + "category": "SEQUENCE_INFORMATION", + "description": "in Ref. 9; BAG35969", + "alternativeSequence": "L", + "begin": "71", + "end": "71", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000305" + } + ] + }, + { + "type": "CONFLICT", + "category": "SEQUENCE_INFORMATION", + "description": "in Ref. 8; AAN01267", + "alternativeSequence": "A", + "begin": "216", + "end": "216", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000305" + } + ] + }, + { + "type": "CONFLICT", + "category": "SEQUENCE_INFORMATION", + "description": "in Ref. 10; BAD96745", + "alternativeSequence": "P", + "begin": "261", + "end": "261", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000305" + } + ] + }, + { + "type": "CONFLICT", + "category": "SEQUENCE_INFORMATION", + "description": "in Ref. 14; AAH12481", + "alternativeSequence": "P", + "begin": "402", + "end": "402", + "molecule": "", + "evidences": [ + { + "code": "ECO:0000305" + } + ] + }, + { + "type": "STRAND", + "category": "STRUCTURAL", + "begin": "25", + "end": "27", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "3P0G", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/3P0G" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "31", + "end": "60", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "62", + "end": "64", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "67", + "end": "85", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "87", + "end": "96", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "102", + "end": "136", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "STRAND", + "category": "STRUCTURAL", + "begin": "137", + "end": "139", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "STRAND", + "category": "STRUCTURAL", + "begin": "140", + "end": "142", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "6PS2", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/6PS2" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "147", + "end": "170", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "TURN", + "category": "STRUCTURAL", + "begin": "171", + "end": "174", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "179", + "end": "186", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "STRAND", + "category": "STRUCTURAL", + "begin": "187", + "end": "189", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "3SN6", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/3SN6" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "197", + "end": "207", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "209", + "end": "229", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "TURN", + "category": "STRUCTURAL", + "begin": "235", + "end": "239", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2R4R", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2R4R" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "267", + "end": "298", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "STRAND", + "category": "STRUCTURAL", + "begin": "299", + "end": "303", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "6PS4", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/6PS4" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "305", + "end": "317", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "318", + "end": "320", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "322", + "end": "325", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "326", + "end": "328", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "HELIX", + "category": "STRUCTURAL", + "begin": "330", + "end": "339", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "type": "TURN", + "category": "STRUCTURAL", + "begin": "340", + "end": "342", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "5JQH", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/5JQH" + } + } + ] + }, + { + "type": "TURN", + "category": "STRUCTURAL", + "begin": "345", + "end": "347", + "molecule": "", + "evidences": [ + { + "code": "ECO:0007829", + "source": { + "name": "PDB", + "id": "2R4R", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2R4R" + } + } + ] + } + ], + "dbReferences": [ + { + "type": "EMBL", + "id": "X04827", + "properties": { + "molecule type": "mRNA", + "protein sequence ID": "CAA28511.1" + } + }, + { + "type": "EMBL", + "id": "Y00106", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "CAA68289.1" + } + }, + { + "type": "EMBL", + "id": "M15169", + "properties": { + "molecule type": "mRNA", + "protein sequence ID": "AAA88015.1" + } + }, + { + "type": "EMBL", + "id": "J02960", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "AAA88017.1" + } + }, + { + "type": "EMBL", + "id": "AF022953", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "AAB82148.1" + } + }, + { + "type": "EMBL", + "id": "AF022954", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "AAB82149.1" + } + }, + { + "type": "EMBL", + "id": "AF022955", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "AAB82150.1" + } + }, + { + "type": "EMBL", + "id": "AF022956", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "AAB82151.1" + } + }, + { + "type": "EMBL", + "id": "AF169225", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "AAD48036.1" + } + }, + { + "type": "EMBL", + "id": "AF202305", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "AAF17569.1" + } + }, + { + "type": "EMBL", + "id": "AF203386", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "AAF20199.1" + } + }, + { + "type": "EMBL", + "id": "AY136741", + "properties": { + "molecule type": "mRNA", + "protein sequence ID": "AAN01267.1" + } + }, + { + "type": "EMBL", + "id": "AK313151", + "properties": { + "molecule type": "mRNA", + "protein sequence ID": "BAG35969.1" + } + }, + { + "type": "EMBL", + "id": "AK223025", + "properties": { + "molecule type": "mRNA", + "protein sequence ID": "BAD96745.1", + "status": "ALT_INIT" + } + }, + { + "type": "EMBL", + "id": "DQ094845", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "AAY88739.1" + } + }, + { + "type": "EMBL", + "id": "EU332834", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "ABY87523.1" + } + }, + { + "type": "EMBL", + "id": "CH471062", + "properties": { + "molecule type": "Genomic_DNA", + "protein sequence ID": "EAW61798.1" + } + }, + { + "type": "EMBL", + "id": "BC012481", + "properties": { + "molecule type": "mRNA", + "protein sequence ID": "AAH12481.3" + } + }, + { + "type": "EMBL", + "id": "BC063486", + "properties": { + "molecule type": "mRNA", + "protein sequence ID": "AAH63486.2" + } + }, + { + "type": "EMBL", + "id": "BC073856", + "properties": { + "molecule type": "mRNA", + "protein sequence ID": "AAH73856.1" + } + }, + { + "type": "CCDS", + "id": "CCDS4292.1" + }, + { + "type": "PIR", + "id": "A27525", + "properties": { + "entry name": "QRHUB2" + } + }, + { + "type": "RefSeq", + "id": "NP_000015.1", + "properties": { + "nucleotide sequence ID": "NM_000024.5" + } + }, + { + "type": "PDB", + "id": "1GQ4", + "properties": { + "method": "X-ray", + "chains": "A=409-413", + "resolution": "1.90 A" + } + }, + { + "type": "PDB", + "id": "2R4R", + "properties": { + "method": "X-ray", + "chains": "A=1-365", + "resolution": "3.40 A" + } + }, + { + "type": "PDB", + "id": "2R4S", + "properties": { + "method": "X-ray", + "chains": "A=24-365", + "resolution": "3.40 A" + } + }, + { + "type": "PDB", + "id": "2RH1", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=263-365", + "resolution": "2.40 A" + } + }, + { + "type": "PDB", + "id": "3D4S", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=263-348", + "resolution": "2.80 A" + } + }, + { + "type": "PDB", + "id": "3KJ6", + "properties": { + "method": "X-ray", + "chains": "A=2-365", + "resolution": "3.40 A" + } + }, + { + "type": "PDB", + "id": "3NY8", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=263-348", + "resolution": "2.84 A" + } + }, + { + "type": "PDB", + "id": "3NY9", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=263-348", + "resolution": "2.84 A" + } + }, + { + "type": "PDB", + "id": "3NYA", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=263-348", + "resolution": "3.16 A" + } + }, + { + "type": "PDB", + "id": "3P0G", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=263-365", + "resolution": "3.50 A" + } + }, + { + "type": "PDB", + "id": "3PDS", + "properties": { + "method": "X-ray", + "chains": "A=25-230, A=264-348", + "resolution": "3.50 A" + } + }, + { + "type": "PDB", + "id": "3SN6", + "properties": { + "method": "X-ray", + "chains": "R=29-365", + "resolution": "3.20 A" + } + }, + { + "type": "PDB", + "id": "4GBR", + "properties": { + "method": "X-ray", + "chains": "A=29-365", + "resolution": "3.99 A" + } + }, + { + "type": "PDB", + "id": "4LDE", + "properties": { + "method": "X-ray", + "chains": "A=29-348", + "resolution": "2.79 A" + } + }, + { + "type": "PDB", + "id": "4LDL", + "properties": { + "method": "X-ray", + "chains": "A=29-348", + "resolution": "3.10 A" + } + }, + { + "type": "PDB", + "id": "4LDO", + "properties": { + "method": "X-ray", + "chains": "A=29-348", + "resolution": "3.20 A" + } + }, + { + "type": "PDB", + "id": "4QKX", + "properties": { + "method": "X-ray", + "chains": "A=29-348", + "resolution": "3.30 A" + } + }, + { + "type": "PDB", + "id": "5D5A", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=263-365", + "resolution": "2.48 A" + } + }, + { + "type": "PDB", + "id": "5D5B", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=263-365", + "resolution": "3.80 A" + } + }, + { + "type": "PDB", + "id": "5D6L", + "properties": { + "method": "X-ray", + "chains": "A=1-223, A=264-365", + "resolution": "3.20 A" + } + }, + { + "type": "PDB", + "id": "5JQH", + "properties": { + "method": "X-ray", + "chains": "A/B=30-348", + "resolution": "3.20 A" + } + }, + { + "type": "PDB", + "id": "5X7D", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=264-365", + "resolution": "2.70 A" + } + }, + { + "type": "PDB", + "id": "6E67", + "properties": { + "method": "X-ray", + "chains": "A/B=1-232, A/B=268-365", + "resolution": "3.70 A" + } + }, + { + "type": "PDB", + "id": "6KR8", + "properties": { + "method": "NMR", + "chains": "A=25-350" + } + }, + { + "type": "PDB", + "id": "6MXT", + "properties": { + "method": "X-ray", + "chains": "A=29-365", + "resolution": "2.96 A" + } + }, + { + "type": "PDB", + "id": "6N48", + "properties": { + "method": "X-ray", + "chains": "A=29-348", + "resolution": "3.20 A" + } + }, + { + "type": "PDB", + "id": "6NI3", + "properties": { + "method": "EM", + "chains": "R=29-341", + "resolution": "3.80 A" + } + }, + { + "type": "PDB", + "id": "6OBA", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=264-365", + "resolution": "3.10 A" + } + }, + { + "type": "PDB", + "id": "6PRZ", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=264-348", + "resolution": "2.80 A" + } + }, + { + "type": "PDB", + "id": "6PS0", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=264-348", + "resolution": "3.40 A" + } + }, + { + "type": "PDB", + "id": "6PS1", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=264-348", + "resolution": "3.20 A" + } + }, + { + "type": "PDB", + "id": "6PS2", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=264-348", + "resolution": "2.40 A" + } + }, + { + "type": "PDB", + "id": "6PS3", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=264-348", + "resolution": "2.50 A" + } + }, + { + "type": "PDB", + "id": "6PS4", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=264-348", + "resolution": "2.60 A" + } + }, + { + "type": "PDB", + "id": "6PS5", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=264-348", + "resolution": "2.90 A" + } + }, + { + "type": "PDB", + "id": "6PS6", + "properties": { + "method": "X-ray", + "chains": "A=1-230, A=264-348", + "resolution": "2.70 A" + } + }, + { + "type": "PDB", + "id": "7BZ2", + "properties": { + "method": "EM", + "chains": "R=1-348", + "resolution": "3.82 A" + } + }, + { + "type": "PDB", + "id": "7DHI", + "properties": { + "method": "EM", + "chains": "R=1-348", + "resolution": "3.26 A" + } + }, + { + "type": "PDB", + "id": "7DHR", + "properties": { + "method": "EM", + "chains": "R=1-348", + "resolution": "3.80 A" + } + }, + { + "type": "PDB", + "id": "7XK9", + "properties": { + "method": "X-ray", + "chains": "A=29-348", + "resolution": "3.40 A" + } + }, + { + "type": "PDB", + "id": "7XKA", + "properties": { + "method": "X-ray", + "chains": "A=29-348", + "resolution": "3.10 A" + } + }, + { + "type": "PDB", + "id": "8JJ8", + "properties": { + "method": "EM", + "chains": "F=29-230, F=263-340", + "resolution": "3.20 A" + } + }, + { + "type": "PDB", + "id": "8JJO", + "properties": { + "method": "EM", + "chains": "F=29-340", + "resolution": "3.40 A" + } + }, + { + "type": "PDBsum", + "id": "1GQ4" + }, + { + "type": "PDBsum", + "id": "2R4R" + }, + { + "type": "PDBsum", + "id": "2R4S" + }, + { + "type": "PDBsum", + "id": "2RH1" + }, + { + "type": "PDBsum", + "id": "3D4S" + }, + { + "type": "PDBsum", + "id": "3KJ6" + }, + { + "type": "PDBsum", + "id": "3NY8" + }, + { + "type": "PDBsum", + "id": "3NY9" + }, + { + "type": "PDBsum", + "id": "3NYA" + }, + { + "type": "PDBsum", + "id": "3P0G" + }, + { + "type": "PDBsum", + "id": "3PDS" + }, + { + "type": "PDBsum", + "id": "3SN6" + }, + { + "type": "PDBsum", + "id": "4GBR" + }, + { + "type": "PDBsum", + "id": "4LDE" + }, + { + "type": "PDBsum", + "id": "4LDL" + }, + { + "type": "PDBsum", + "id": "4LDO" + }, + { + "type": "PDBsum", + "id": "4QKX" + }, + { + "type": "PDBsum", + "id": "5D5A" + }, + { + "type": "PDBsum", + "id": "5D5B" + }, + { + "type": "PDBsum", + "id": "5D6L" + }, + { + "type": "PDBsum", + "id": "5JQH" + }, + { + "type": "PDBsum", + "id": "5X7D" + }, + { + "type": "PDBsum", + "id": "6E67" + }, + { + "type": "PDBsum", + "id": "6KR8" + }, + { + "type": "PDBsum", + "id": "6MXT" + }, + { + "type": "PDBsum", + "id": "6N48" + }, + { + "type": "PDBsum", + "id": "6NI3" + }, + { + "type": "PDBsum", + "id": "6OBA" + }, + { + "type": "PDBsum", + "id": "6PRZ" + }, + { + "type": "PDBsum", + "id": "6PS0" + }, + { + "type": "PDBsum", + "id": "6PS1" + }, + { + "type": "PDBsum", + "id": "6PS2" + }, + { + "type": "PDBsum", + "id": "6PS3" + }, + { + "type": "PDBsum", + "id": "6PS4" + }, + { + "type": "PDBsum", + "id": "6PS5" + }, + { + "type": "PDBsum", + "id": "6PS6" + }, + { + "type": "PDBsum", + "id": "7BZ2" + }, + { + "type": "PDBsum", + "id": "7DHI" + }, + { + "type": "PDBsum", + "id": "7DHR" + }, + { + "type": "PDBsum", + "id": "7XK9" + }, + { + "type": "PDBsum", + "id": "7XKA" + }, + { + "type": "PDBsum", + "id": "8JJ8" + }, + { + "type": "PDBsum", + "id": "8JJO" + }, + { + "type": "AlphaFoldDB", + "id": "P07550" + }, + { + "type": "EMDB", + "id": "EMD-30249" + }, + { + "type": "EMDB", + "id": "EMD-30681" + }, + { + "type": "EMDB", + "id": "EMD-30682" + }, + { + "type": "EMDB", + "id": "EMD-36342" + }, + { + "type": "EMDB", + "id": "EMD-36360" + }, + { + "type": "EMDB", + "id": "EMD-36361" + }, + { + "type": "SMR", + "id": "P07550" + }, + { + "type": "BioGRID", + "id": "106663", + "properties": { + "interactions": "326" + } + }, + { + "type": "CORUM", + "id": "P07550" + }, + { + "type": "DIP", + "id": "DIP-33948N" + }, + { + "type": "ELM", + "id": "P07550" + }, + { + "type": "IntAct", + "id": "P07550", + "properties": { + "interactions": "107" + } + }, + { + "type": "MINT", + "id": "P07550" + }, + { + "type": "STRING", + "id": "9606.ENSP00000305372" + }, + { + "type": "BindingDB", + "id": "P07550" + }, + { + "type": "ChEMBL", + "id": "CHEMBL210" + }, + { + "type": "DrugBank", + "id": "DB07543", + "properties": { + "generic name": "(S)-carazolol" + } + }, + { + "type": "DrugBank", + "id": "DB01193", + "properties": { + "generic name": "Acebutolol" + } + }, + { + "type": "DrugBank", + "id": "DB00866", + "properties": { + "generic name": "Alprenolol" + } + }, + { + "type": "DrugBank", + "id": "DB01118", + "properties": { + "generic name": "Amiodarone" + } + }, + { + "type": "DrugBank", + "id": "DB00182", + "properties": { + "generic name": "Amphetamine" + } + }, + { + "type": "DrugBank", + "id": "DB01102", + "properties": { + "generic name": "Arbutamine" + } + }, + { + "type": "DrugBank", + "id": "DB01274", + "properties": { + "generic name": "Arformoterol" + } + }, + { + "type": "DrugBank", + "id": "DB01238", + "properties": { + "generic name": "Aripiprazole" + } + }, + { + "type": "DrugBank", + "id": "DB09204", + "properties": { + "generic name": "Arotinolol" + } + }, + { + "type": "DrugBank", + "id": "DB06216", + "properties": { + "generic name": "Asenapine" + } + }, + { + "type": "DrugBank", + "id": "DB00335", + "properties": { + "generic name": "Atenolol" + } + }, + { + "type": "DrugBank", + "id": "DB01408", + "properties": { + "generic name": "Bambuterol" + } + }, + { + "type": "DrugBank", + "id": "DB05590", + "properties": { + "generic name": "Bedoradrine" + } + }, + { + "type": "DrugBank", + "id": "DB09013", + "properties": { + "generic name": "Befunolol" + } + }, + { + "type": "DrugBank", + "id": "DB00195", + "properties": { + "generic name": "Betaxolol" + } + }, + { + "type": "DrugBank", + "id": "DB00217", + "properties": { + "generic name": "Bethanidine" + } + }, + { + "type": "DrugBank", + "id": "DB01295", + "properties": { + "generic name": "Bevantolol" + } + }, + { + "type": "DrugBank", + "id": "DB00612", + "properties": { + "generic name": "Bisoprolol" + } + }, + { + "type": "DrugBank", + "id": "DB00901", + "properties": { + "generic name": "Bitolterol" + } + }, + { + "type": "DrugBank", + "id": "DB08807", + "properties": { + "generic name": "Bopindolol" + } + }, + { + "type": "DrugBank", + "id": "DB06726", + "properties": { + "generic name": "Bufuralol" + } + }, + { + "type": "DrugBank", + "id": "DB08808", + "properties": { + "generic name": "Bupranolol" + } + }, + { + "type": "DrugBank", + "id": "DB00248", + "properties": { + "generic name": "Cabergoline" + } + }, + { + "type": "DrugBank", + "id": "DB00521", + "properties": { + "generic name": "Carteolol" + } + }, + { + "type": "DrugBank", + "id": "DB01136", + "properties": { + "generic name": "Carvedilol" + } + }, + { + "type": "DrugBank", + "id": "DB04846", + "properties": { + "generic name": "Celiprolol" + } + }, + { + "type": "DrugBank", + "id": "DB01407", + "properties": { + "generic name": "Clenbuterol" + } + }, + { + "type": "DrugBank", + "id": "DB00785", + "properties": { + "generic name": "Cryptenamine" + } + }, + { + "type": "DrugBank", + "id": "DB01151", + "properties": { + "generic name": "Desipramine" + } + }, + { + "type": "DrugBank", + "id": "DB11273", + "properties": { + "generic name": "Dihydroergocornine" + } + }, + { + "type": "DrugBank", + "id": "DB13345", + "properties": { + "generic name": "Dihydroergocristine" + } + }, + { + "type": "DrugBank", + "id": "DB00449", + "properties": { + "generic name": "Dipivefrin" + } + }, + { + "type": "DrugBank", + "id": "DB11278", + "properties": { + "generic name": "DL-Methylephedrine" + } + }, + { + "type": "DrugBank", + "id": "DB00841", + "properties": { + "generic name": "Dobutamine" + } + }, + { + "type": "DrugBank", + "id": "DB09273", + "properties": { + "generic name": "Doxofylline" + } + }, + { + "type": "DrugBank", + "id": "DB06262", + "properties": { + "generic name": "Droxidopa" + } + }, + { + "type": "DrugBank", + "id": "DB01363", + "properties": { + "generic name": "Ephedra sinica root" + } + }, + { + "type": "DrugBank", + "id": "DB01364", + "properties": { + "generic name": "Ephedrine" + } + }, + { + "type": "DrugBank", + "id": "DB00668", + "properties": { + "generic name": "Epinephrine" + } + }, + { + "type": "DrugBank", + "id": "DB01049", + "properties": { + "generic name": "Ergoloid mesylate" + } + }, + { + "type": "DrugBank", + "id": "DB11587", + "properties": { + "generic name": "Etafedrine" + } + }, + { + "type": "DrugBank", + "id": "DB01288", + "properties": { + "generic name": "Fenoterol" + } + }, + { + "type": "DrugBank", + "id": "DB00983", + "properties": { + "generic name": "Formoterol" + } + }, + { + "type": "DrugBank", + "id": "DB05039", + "properties": { + "generic name": "Indacaterol" + } + }, + { + "type": "DrugBank", + "id": "DB00221", + "properties": { + "generic name": "Isoetharine" + } + }, + { + "type": "DrugBank", + "id": "DB01064", + "properties": { + "generic name": "Isoprenaline" + } + }, + { + "type": "DrugBank", + "id": "DB00598", + "properties": { + "generic name": "Labetalol" + } + }, + { + "type": "DrugBank", + "id": "DB01210", + "properties": { + "generic name": "Levobunolol" + } + }, + { + "type": "DrugBank", + "id": "DB13139", + "properties": { + "generic name": "Levosalbutamol" + } + }, + { + "type": "DrugBank", + "id": "DB01365", + "properties": { + "generic name": "Mephentermine" + } + }, + { + "type": "DrugBank", + "id": "DB13624", + "properties": { + "generic name": "Methoxyphenamine" + } + }, + { + "type": "DrugBank", + "id": "DB01214", + "properties": { + "generic name": "Metipranolol" + } + }, + { + "type": "DrugBank", + "id": "DB00264", + "properties": { + "generic name": "Metoprolol" + } + }, + { + "type": "DrugBank", + "id": "DB01203", + "properties": { + "generic name": "Nadolol" + } + }, + { + "type": "DrugBank", + "id": "DB05849", + "properties": { + "generic name": "NCX 950" + } + }, + { + "type": "DrugBank", + "id": "DB04861", + "properties": { + "generic name": "Nebivolol" + } + }, + { + "type": "DrugBank", + "id": "DB00368", + "properties": { + "generic name": "Norepinephrine" + } + }, + { + "type": "DrugBank", + "id": "DB00540", + "properties": { + "generic name": "Nortriptyline" + } + }, + { + "type": "DrugBank", + "id": "DB00334", + "properties": { + "generic name": "Olanzapine" + } + }, + { + "type": "DrugBank", + "id": "DB09080", + "properties": { + "generic name": "Olodaterol" + } + }, + { + "type": "DrugBank", + "id": "DB00816", + "properties": { + "generic name": "Orciprenaline" + } + }, + { + "type": "DrugBank", + "id": "DB01580", + "properties": { + "generic name": "Oxprenolol" + } + }, + { + "type": "DrugBank", + "id": "DB00715", + "properties": { + "generic name": "Paroxetine" + } + }, + { + "type": "DrugBank", + "id": "DB01359", + "properties": { + "generic name": "Penbutolol" + } + }, + { + "type": "DrugBank", + "id": "DB00925", + "properties": { + "generic name": "Phenoxybenzamine" + } + }, + { + "type": "DrugBank", + "id": "DB00397", + "properties": { + "generic name": "Phenylpropanolamine" + } + }, + { + "type": "DrugBank", + "id": "DB00960", + "properties": { + "generic name": "Pindolol" + } + }, + { + "type": "DrugBank", + "id": "DB01291", + "properties": { + "generic name": "Pirbuterol" + } + }, + { + "type": "DrugBank", + "id": "DB01366", + "properties": { + "generic name": "Procaterol" + } + }, + { + "type": "DrugBank", + "id": "DB01182", + "properties": { + "generic name": "Propafenone" + } + }, + { + "type": "DrugBank", + "id": "DB00571", + "properties": { + "generic name": "Propranolol" + } + }, + { + "type": "DrugBank", + "id": "DB06814", + "properties": { + "generic name": "Protokylol" + } + }, + { + "type": "DrugBank", + "id": "DB00852", + "properties": { + "generic name": "Pseudoephedrine" + } + }, + { + "type": "DrugBank", + "id": "DB01917", + "properties": { + "generic name": "Putrescine" + } + }, + { + "type": "DrugBank", + "id": "DB11124", + "properties": { + "generic name": "Racepinephrine" + } + }, + { + "type": "DrugBank", + "id": "DB00867", + "properties": { + "generic name": "Ritodrine" + } + }, + { + "type": "DrugBank", + "id": "DB01001", + "properties": { + "generic name": "Salbutamol" + } + }, + { + "type": "DrugBank", + "id": "DB00938", + "properties": { + "generic name": "Salmeterol" + } + }, + { + "type": "DrugBank", + "id": "DB00489", + "properties": { + "generic name": "Sotalol" + } + }, + { + "type": "DrugBank", + "id": "DB03566", + "properties": { + "generic name": "Spermidine" + } + }, + { + "type": "DrugBank", + "id": "DB00127", + "properties": { + "generic name": "Spermine" + } + }, + { + "type": "DrugBank", + "id": "DB00871", + "properties": { + "generic name": "Terbutaline" + } + }, + { + "type": "DrugBank", + "id": "DB00373", + "properties": { + "generic name": "Timolol" + } + }, + { + "type": "DrugBank", + "id": "DB00726", + "properties": { + "generic name": "Trimipramine" + } + }, + { + "type": "DrugBank", + "id": "DB12248", + "properties": { + "generic name": "Tulobuterol" + } + }, + { + "type": "DrugBank", + "id": "DB09082", + "properties": { + "generic name": "Vilanterol" + } + }, + { + "type": "DrugBank", + "id": "DB09185", + "properties": { + "generic name": "Viloxazine" + } + }, + { + "type": "DrugCentral", + "id": "P07550" + }, + { + "type": "GuidetoPHARMACOLOGY", + "id": "29" + }, + { + "type": "MoonDB", + "id": "P07550", + "properties": { + "type": "Predicted" + } + }, + { + "type": "TCDB", + "id": "9.A.14.3.5", + "properties": { + "family name": "the g-protein-coupled receptor (gpcr) family" + } + }, + { + "type": "GlyCosmos", + "id": "P07550", + "properties": { + "glycosylation": "2 sites, No reported glycans" + } + }, + { + "type": "GlyGen", + "id": "P07550", + "properties": { + "glycosylation": "4 sites, 1 O-linked glycan (1 site)" + } + }, + { + "type": "iPTMnet", + "id": "P07550" + }, + { + "type": "PhosphoSitePlus", + "id": "P07550" + }, + { + "type": "SwissPalm", + "id": "P07550" + }, + { + "type": "BioMuta", + "id": "ADRB2" + }, + { + "type": "DMDM", + "id": "296439450" + }, + { + "type": "EPD", + "id": "P07550" + }, + { + "type": "jPOST", + "id": "P07550" + }, + { + "type": "MassIVE", + "id": "P07550" + }, + { + "type": "PaxDb", + "id": "9606-ENSP00000305372" + }, + { + "type": "PeptideAtlas", + "id": "P07550" + }, + { + "type": "ProteomicsDB", + "id": "52013" + }, + { + "type": "ABCD", + "id": "P07550", + "properties": { + "antibodies": "44 sequenced antibodies" + } + }, + { + "type": "Antibodypedia", + "id": "15959", + "properties": { + "antibodies": "1320 antibodies from 44 providers" + } + }, + { + "type": "DNASU", + "id": "154" + }, + { + "type": "Ensembl", + "id": "ENST00000305988.6", + "properties": { + "gene ID": "ENSG00000169252.6", + "protein sequence ID": "ENSP00000305372.4" + } + }, + { + "type": "GeneID", + "id": "154" + }, + { + "type": "KEGG", + "id": "hsa:154" + }, + { + "type": "MANE-Select", + "id": "ENST00000305988.6", + "properties": { + "RefSeq nucleotide sequence ID": "NM_000024.6", + "RefSeq protein sequence ID": "NP_000015.2", + "protein sequence ID": "ENSP00000305372.4" + } + }, + { + "type": "AGR", + "id": "HGNC:286" + }, + { + "type": "CTD", + "id": "154" + }, + { + "type": "DisGeNET", + "id": "154" + }, + { + "type": "GeneCards", + "id": "ADRB2" + }, + { + "type": "HGNC", + "id": "HGNC:286", + "properties": { + "gene designation": "ADRB2" + } + }, + { + "type": "HPA", + "id": "ENSG00000169252", + "properties": { + "expression patterns": "Low tissue specificity" + } + }, + { + "type": "MIM", + "id": "109690", + "properties": { + "type": "gene+phenotype" + } + }, + { + "type": "neXtProt", + "id": "NX_P07550" + }, + { + "type": "OpenTargets", + "id": "ENSG00000169252" + }, + { + "type": "PharmGKB", + "id": "PA39" + }, + { + "type": "VEuPathDB", + "id": "HostDB:ENSG00000169252" + }, + { + "type": "eggNOG", + "id": "KOG3656", + "properties": { + "taxonomic scope": "Eukaryota" + } + }, + { + "type": "GeneTree", + "id": "ENSGT00940000159538" + }, + { + "type": "HOGENOM", + "id": "CLU_009579_11_0_1" + }, + { + "type": "InParanoid", + "id": "P07550" + }, + { + "type": "OMA", + "id": "FGASHIM" + }, + { + "type": "OrthoDB", + "id": "2900736at2759" + }, + { + "type": "PhylomeDB", + "id": "P07550" + }, + { + "type": "TreeFam", + "id": "TF316350" + }, + { + "type": "PathwayCommons", + "id": "P07550" + }, + { + "type": "Reactome", + "id": "R-HSA-390696", + "properties": { + "pathway name": "Adrenoceptors" + } + }, + { + "type": "Reactome", + "id": "R-HSA-418555", + "properties": { + "pathway name": "G alpha (s) signalling events" + } + }, + { + "type": "Reactome", + "id": "R-HSA-5689880", + "properties": { + "pathway name": "Ub-specific processing proteases" + } + }, + { + "type": "Reactome", + "id": "R-HSA-8856825", + "properties": { + "pathway name": "Cargo recognition for clathrin-mediated endocytosis" + } + }, + { + "type": "Reactome", + "id": "R-HSA-8856828", + "properties": { + "pathway name": "Clathrin-mediated endocytosis" + } + }, + { + "type": "SignaLink", + "id": "P07550" + }, + { + "type": "SIGNOR", + "id": "P07550" + }, + { + "type": "BioGRID-ORCS", + "id": "154", + "properties": { + "hits": "10 hits in 1160 CRISPR screens" + } + }, + { + "type": "ChiTaRS", + "id": "ADRB2", + "properties": { + "organism name": "human" + } + }, + { + "type": "EvolutionaryTrace", + "id": "P07550" + }, + { + "type": "GeneWiki", + "id": "Beta-2_adrenergic_receptor" + }, + { + "type": "GenomeRNAi", + "id": "154" + }, + { + "type": "Pharos", + "id": "P07550", + "properties": { + "development level": "Tclin" + } + }, + { + "type": "PRO", + "id": "PR:P07550" + }, + { + "type": "Proteomes", + "id": "UP000005640", + "properties": { + "component": "Chromosome 5" + } + }, + { + "type": "RNAct", + "id": "P07550", + "properties": { + "molecule type": "Protein" + } + }, + { + "type": "Bgee", + "id": "ENSG00000169252", + "properties": { + "expression patterns": "Expressed in cartilage tissue and 162 other cell types or tissues" + } + }, + { + "type": "ExpressionAtlas", + "id": "P07550", + "properties": { + "expression patterns": "baseline and differential" + } + }, + { + "type": "Genevisible", + "id": "P07550", + "properties": { + "organism ID": "HS" + } + }, + { + "type": "GO", + "id": "GO:0016324", + "properties": { + "term": "C:apical plasma membrane", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0030669", + "properties": { + "term": "C:clathrin-coated endocytic vesicle membrane", + "source": "TAS:Reactome" + } + }, + { + "type": "GO", + "id": "GO:0005769", + "properties": { + "term": "C:early endosome", + "source": "IEA:UniProtKB-SubCell" + } + }, + { + "type": "GO", + "id": "GO:0005768", + "properties": { + "term": "C:endosome", + "source": "TAS:ProtInc" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "10734107", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/10734107", + "alternativeUrl": "https://europepmc.org/abstract/MED/10734107" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0010008", + "properties": { + "term": "C:endosome membrane", + "source": "TAS:Reactome" + } + }, + { + "type": "GO", + "id": "GO:0005794", + "properties": { + "term": "C:Golgi apparatus", + "source": "IDA:UniProtKB" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "27481942", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/27481942", + "alternativeUrl": "https://europepmc.org/abstract/MED/27481942" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0005764", + "properties": { + "term": "C:lysosome", + "source": "TAS:ProtInc" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "9507004", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/9507004", + "alternativeUrl": "https://europepmc.org/abstract/MED/9507004" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0016020", + "properties": { + "term": "C:membrane", + "source": "NAS:ARUK-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20395454", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20395454", + "alternativeUrl": "https://europepmc.org/abstract/MED/20395454" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0098992", + "properties": { + "term": "C:neuronal dense core vesicle", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0005634", + "properties": { + "term": "C:nucleus", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0005886", + "properties": { + "term": "C:plasma membrane", + "source": "IDA:UniProtKB" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "23166351", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/23166351", + "alternativeUrl": "https://europepmc.org/abstract/MED/23166351" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "27481942", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/27481942", + "alternativeUrl": "https://europepmc.org/abstract/MED/27481942" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0043235", + "properties": { + "term": "C:receptor complex", + "source": "IDA:HGNC-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "15123695", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/15123695", + "alternativeUrl": "https://europepmc.org/abstract/MED/15123695" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "23382219", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/23382219", + "alternativeUrl": "https://europepmc.org/abstract/MED/23382219" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0008179", + "properties": { + "term": "F:adenylate cyclase binding", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0001540", + "properties": { + "term": "F:amyloid-beta binding", + "source": "IDA:ARUK-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20395454", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20395454", + "alternativeUrl": "https://europepmc.org/abstract/MED/20395454" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0004941", + "properties": { + "term": "F:beta2-adrenergic receptor activity", + "source": "IDA:HGNC-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "15123695", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/15123695", + "alternativeUrl": "https://europepmc.org/abstract/MED/15123695" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19710023", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19710023", + "alternativeUrl": "https://europepmc.org/abstract/MED/19710023" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0042802", + "properties": { + "term": "F:identical protein binding", + "source": "IPI:IntAct" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "15518545", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/15518545", + "alternativeUrl": "https://europepmc.org/abstract/MED/15518545" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19763081", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19763081", + "alternativeUrl": "https://europepmc.org/abstract/MED/19763081" + } + }, + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20590567", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20590567", + "alternativeUrl": "https://europepmc.org/abstract/MED/20590567" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0051380", + "properties": { + "term": "F:norepinephrine binding", + "source": "IDA:HGNC-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "15123695", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/15123695", + "alternativeUrl": "https://europepmc.org/abstract/MED/15123695" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0015459", + "properties": { + "term": "F:potassium channel regulator activity", + "source": "IDA:BHF-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "12297500", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/12297500", + "alternativeUrl": "https://europepmc.org/abstract/MED/12297500" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0042803", + "properties": { + "term": "F:protein homodimerization activity", + "source": "IDA:HGNC-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "15123695", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/15123695", + "alternativeUrl": "https://europepmc.org/abstract/MED/15123695" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0044877", + "properties": { + "term": "F:protein-containing complex binding", + "source": "IPI:ARUK-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20395454", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20395454", + "alternativeUrl": "https://europepmc.org/abstract/MED/20395454" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0007190", + "properties": { + "term": "P:activation of adenylate cyclase activity", + "source": "IDA:HGNC-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "15123695", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/15123695", + "alternativeUrl": "https://europepmc.org/abstract/MED/15123695" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0007171", + "properties": { + "term": "P:activation of transmembrane receptor protein tyrosine kinase activity", + "source": "TAS:ProtInc" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "10734107", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/10734107", + "alternativeUrl": "https://europepmc.org/abstract/MED/10734107" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0071880", + "properties": { + "term": "P:adenylate cyclase-activating adrenergic receptor signaling pathway", + "source": "IBA:GO_Central" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "21873635", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/21873635", + "alternativeUrl": "https://europepmc.org/abstract/MED/21873635" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0007188", + "properties": { + "term": "P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway", + "source": "TAS:ProtInc" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "2823249", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/2823249", + "alternativeUrl": "https://europepmc.org/abstract/MED/2823249" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0071875", + "properties": { + "term": "P:adrenergic receptor signaling pathway", + "source": "IDA:CAFA" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "19710023", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/19710023", + "alternativeUrl": "https://europepmc.org/abstract/MED/19710023" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0045453", + "properties": { + "term": "P:bone resorption", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0050873", + "properties": { + "term": "P:brown fat cell differentiation", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0007166", + "properties": { + "term": "P:cell surface receptor signaling pathway", + "source": "TAS:ProtInc" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "1371121", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/1371121", + "alternativeUrl": "https://europepmc.org/abstract/MED/1371121" + } + } + ] + }, + { + "type": "GO", + "id": "GO:1904646", + "properties": { + "term": "P:cellular response to amyloid-beta", + "source": "IGI:ARUK-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20395454", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20395454", + "alternativeUrl": "https://europepmc.org/abstract/MED/20395454" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0002032", + "properties": { + "term": "P:desensitization of G protein-coupled receptor signaling pathway by arrestin", + "source": "IDA:HGNC-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "15123695", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/15123695", + "alternativeUrl": "https://europepmc.org/abstract/MED/15123695" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0002024", + "properties": { + "term": "P:diet induced thermogenesis", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0008333", + "properties": { + "term": "P:endosome to lysosome transport", + "source": "TAS:ProtInc" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "9507004", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/9507004", + "alternativeUrl": "https://europepmc.org/abstract/MED/9507004" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0031649", + "properties": { + "term": "P:heat generation", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0040015", + "properties": { + "term": "P:negative regulation of multicellular organism growth", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0045986", + "properties": { + "term": "P:negative regulation of smooth muscle contraction", + "source": "IBA:GO_Central" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "21873635", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/21873635", + "alternativeUrl": "https://europepmc.org/abstract/MED/21873635" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0002025", + "properties": { + "term": "P:norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure", + "source": "IBA:GO_Central" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "21873635", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/21873635", + "alternativeUrl": "https://europepmc.org/abstract/MED/21873635" + } + } + ] + }, + { + "type": "GO", + "id": "GO:2000969", + "properties": { + "term": "P:positive regulation of AMPA receptor activity", + "source": "IGI:ARUK-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20395454", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20395454", + "alternativeUrl": "https://europepmc.org/abstract/MED/20395454" + } + } + ] + }, + { + "type": "GO", + "id": "GO:1901098", + "properties": { + "term": "P:positive regulation of autophagosome maturation", + "source": "IDA:GO_Central" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "23708524", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/23708524", + "alternativeUrl": "https://europepmc.org/abstract/MED/23708524" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0030501", + "properties": { + "term": "P:positive regulation of bone mineralization", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:2000481", + "properties": { + "term": "P:positive regulation of cAMP-dependent protein kinase activity", + "source": "TAS:ARUK-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20395454", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20395454", + "alternativeUrl": "https://europepmc.org/abstract/MED/20395454" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0120162", + "properties": { + "term": "P:positive regulation of cold-induced thermogenesis", + "source": "ISS:YuBioLab" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "12387862", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/12387862", + "alternativeUrl": "https://europepmc.org/abstract/MED/12387862" + } + } + ] + }, + { + "type": "GO", + "id": "GO:1904504", + "properties": { + "term": "P:positive regulation of lipophagy", + "source": "IDA:GO_Central" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "23708524", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/23708524", + "alternativeUrl": "https://europepmc.org/abstract/MED/23708524" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0043410", + "properties": { + "term": "P:positive regulation of MAPK cascade", + "source": "IDA:HGNC-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "15123695", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/15123695", + "alternativeUrl": "https://europepmc.org/abstract/MED/15123695" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0061885", + "properties": { + "term": "P:positive regulation of mini excitatory postsynaptic potential", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0010739", + "properties": { + "term": "P:positive regulation of protein kinase A signaling", + "source": "IGI:ARUK-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20395454", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20395454", + "alternativeUrl": "https://europepmc.org/abstract/MED/20395454" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0071902", + "properties": { + "term": "P:positive regulation of protein serine/threonine kinase activity", + "source": "IGI:ARUK-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20395454", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20395454", + "alternativeUrl": "https://europepmc.org/abstract/MED/20395454" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0045944", + "properties": { + "term": "P:positive regulation of transcription by RNA polymerase II", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0006898", + "properties": { + "term": "P:receptor-mediated endocytosis", + "source": "IDA:HGNC-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "15123695", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/15123695", + "alternativeUrl": "https://europepmc.org/abstract/MED/15123695" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0002028", + "properties": { + "term": "P:regulation of sodium ion transport", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0009409", + "properties": { + "term": "P:response to cold", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:1990911", + "properties": { + "term": "P:response to psychosocial stress", + "source": "TAS:ARUK-UCL" + }, + "evidences": [ + { + "code": "ECO:0000269", + "source": { + "name": "PubMed", + "id": "20395454", + "url": "http://www.ncbi.nlm.nih.gov/pubmed/20395454", + "alternativeUrl": "https://europepmc.org/abstract/MED/20395454" + } + } + ] + }, + { + "type": "GO", + "id": "GO:0006939", + "properties": { + "term": "P:smooth muscle contraction", + "source": "IEA:Ensembl" + } + }, + { + "type": "GO", + "id": "GO:0006366", + "properties": { + "term": "P:transcription by RNA polymerase II", + "source": "IEA:Ensembl" + } + }, + { + "type": "CDD", + "id": "cd15957", + "properties": { + "match status": "1", + "entry name": "7tmA_Beta2_AR" + } + }, + { + "type": "Gene3D", + "id": "1.20.1070.10", + "properties": { + "match status": "1", + "entry name": "Rhodopsin 7-helix transmembrane proteins" + } + }, + { + "type": "InterPro", + "id": "IPR002233", + "properties": { + "entry name": "ADR_fam" + } + }, + { + "type": "InterPro", + "id": "IPR000332", + "properties": { + "entry name": "ADRB2_rcpt" + } + }, + { + "type": "InterPro", + "id": "IPR000276", + "properties": { + "entry name": "GPCR_Rhodpsn" + } + }, + { + "type": "InterPro", + "id": "IPR017452", + "properties": { + "entry name": "GPCR_Rhodpsn_7TM" + } + }, + { + "type": "PANTHER", + "id": "PTHR24248", + "properties": { + "match status": "1", + "entry name": "ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR" + } + }, + { + "type": "PANTHER", + "id": "PTHR24248:SF21", + "properties": { + "match status": "1", + "entry name": "BETA-2 ADRENERGIC RECEPTOR" + } + }, + { + "type": "Pfam", + "id": "PF00001", + "properties": { + "match status": "1", + "entry name": "7tm_1" + } + }, + { + "type": "PRINTS", + "id": "PR01103", + "properties": { + "entry name": "ADRENERGICR" + } + }, + { + "type": "PRINTS", + "id": "PR00562", + "properties": { + "entry name": "ADRENRGCB2AR" + } + }, + { + "type": "PRINTS", + "id": "PR00237", + "properties": { + "entry name": "GPCRRHODOPSN" + } + }, + { + "type": "SMART", + "id": "SM01381", + "properties": { + "match status": "1", + "entry name": "7TM_GPCR_Srsx" + } + }, + { + "type": "SUPFAM", + "id": "SSF81321", + "properties": { + "match status": "1", + "entry name": "Family A G protein-coupled receptor-like" + } + }, + { + "type": "PROSITE", + "id": "PS00237", + "properties": { + "match status": "1", + "entry name": "G_PROTEIN_RECEP_F1_1" + } + }, + { + "type": "PROSITE", + "id": "PS50262", + "properties": { + "match status": "1", + "entry name": "G_PROTEIN_RECEP_F1_2" + } + } + ], + "keywords": [ + { + "value": "3D-structure" + }, + { + "value": "Cell membrane" + }, + { + "value": "Disulfide bond" + }, + { + "value": "Endosome" + }, + { + "value": "G-protein coupled receptor" + }, + { + "value": "Glycoprotein" + }, + { + "value": "Golgi apparatus" + }, + { + "value": "Hydroxylation" + }, + { + "value": "Lipoprotein" + }, + { + "value": "Membrane" + }, + { + "value": "Palmitate" + }, + { + "value": "Phosphoprotein" + }, + { + "value": "Receptor" + }, + { + "value": "Reference proteome" + }, + { + "value": "Transducer" + }, + { + "value": "Transmembrane" + }, + { + "value": "Transmembrane helix" + }, + { + "value": "Ubl conjugation" + } + ], + "references": [ + { + "citation": { + "type": "journal article", + "publicationDate": "1987", + "title": "Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors.", + "authors": [ + "Chung F.-Z.", + "Lentes K.-U.", + "Gocayne J.D.", + "Fitzgerald M.G.", + "Robinson D.A.", + "Kerlavage A.R.", + "Fraser C.M.", + "Venter J.C." + ], + "publication": { + "journalName": "FEBS Lett." + }, + "location": { + "volume": "211", + "firstPage": "200", + "lastPage": "206" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "3026848" + }, + { + "type": "DOI", + "id": "10.1016/0014-5793(87)81436-9" + } + ] + }, + "source": { + "tissue": [ + { + "value": "Brain" + } + ] + }, + "scope": ["NUCLEOTIDE SEQUENCE [MRNA]", "VARIANT GLN-27"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1987", + "title": "Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.", + "authors": [ + "Kobilka B.K.", + "Frielle T.", + "Dohlman H.G.", + "Bolanowski M.A.", + "Dixon R.A.F.", + "Keller P.", + "Caron M.G.", + "Lefkowitz R.J." + ], + "publication": { + "journalName": "J. Biol. Chem." + }, + "location": { + "volume": "262", + "firstPage": "7321", + "lastPage": "7327" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "3034889" + }, + { + "type": "DOI", + "id": "10.1016/s0021-9258(18)48239-7" + } + ] + }, + "scope": [ + "NUCLEOTIDE SEQUENCE [GENOMIC DNA]", + "VARIANTS ARG-16 AND GLN-27" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1987", + "title": "Primary structure of the human beta-adrenergic receptor gene.", + "authors": ["Schofield P.R.", "Rhee L.M.", "Peralta E.G."], + "publication": { + "journalName": "Nucleic Acids Res." + }, + "location": { + "volume": "15", + "firstPage": "3636", + "lastPage": "3636" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "3033609" + }, + { + "type": "DOI", + "id": "10.1093/nar/15.8.3636" + } + ] + }, + "scope": [ + "NUCLEOTIDE SEQUENCE [GENOMIC DNA]", + "VARIANTS ARG-16 AND GLN-27" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1987", + "title": "cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.", + "authors": [ + "Kobilka B.K.", + "Dixon R.A.F.", + "Frielle T.", + "Dohlman H.G.", + "Bolanowski M.A.", + "Sigal I.S.", + "Yang-Feng T.L.", + "Francke U.", + "Caron M.G.", + "Lefkowitz R.J." + ], + "publication": { + "journalName": "Proc. Natl. Acad. Sci. U.S.A." + }, + "location": { + "volume": "84", + "firstPage": "46", + "lastPage": "50" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "3025863" + }, + { + "type": "DOI", + "id": "10.1073/pnas.84.1.46" + } + ] + }, + "scope": ["NUCLEOTIDE SEQUENCE [MRNA]", "VARIANTS ARG-16 AND GLN-27"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1987", + "title": "Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.", + "authors": [ + "Emorine L.J.", + "Marullo S.", + "Delavier-Klutchko C.", + "Kaveri S.V.", + "Durieu-Trautmann O.", + "Strosberg A.D." + ], + "publication": { + "journalName": "Proc. Natl. Acad. Sci. U.S.A." + }, + "location": { + "volume": "84", + "firstPage": "6995", + "lastPage": "6999" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "2823249" + }, + { + "type": "DOI", + "id": "10.1073/pnas.84.20.6995" + } + ] + }, + "scope": ["NUCLEOTIDE SEQUENCE [GENOMIC DNA]", "VARIANT GLN-27"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1993", + "title": "Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.", + "authors": ["Reihsaus E.", "Innis M.", "Macintyre N.", "Liggett S.B."], + "publication": { + "journalName": "Am. J. Respir. Cell Mol. Biol." + }, + "location": { + "volume": "8", + "firstPage": "334", + "lastPage": "339" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "8383511" + }, + { + "type": "DOI", + "id": "10.1165/ajrcmb/8.3.334" + } + ] + }, + "scope": [ + "NUCLEOTIDE SEQUENCE [GENOMIC DNA]", + "VARIANTS ARG-16; GLN-27; MET-34 AND ILE-164" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2000", + "title": "Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population.", + "authors": [ + "Rupert J.L.", + "Monsalve M.V.", + "Devine D.V.", + "Hochachka P.W." + ], + "publication": { + "journalName": "Ann. Hum. Genet." + }, + "location": { + "volume": "64", + "firstPage": "135", + "lastPage": "143" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "11246467" + }, + { + "type": "DOI", + "id": "10.1017/s0003480000008009" + } + ] + }, + "source": { + "tissue": [ + { + "value": "Blood" + } + ] + }, + "scope": [ + "NUCLEOTIDE SEQUENCE [GENOMIC DNA]", + "VARIANTS GLN-27; LEU-159; PHE-159 AND ARG-375" + ] + }, + { + "citation": { + "type": "submission", + "publicationDate": "JUL-2002", + "title": "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).", + "authors": ["Puhl H.L. III", "Ikeda S.R.", "Aronstam R.S."], + "publication": { + "submissionDatabase": "EMBL/GenBank/DDBJ databases" + } + }, + "source": { + "tissue": [ + { + "value": "Heart" + } + ] + }, + "scope": [ + "NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]", + "VARIANTS ARG-16 AND GLN-27" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2004", + "title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.", + "authors": [ + "Ota T.", + "Suzuki Y.", + "Nishikawa T.", + "Otsuki T.", + "Sugiyama T.", + "Irie R.", + "Wakamatsu A.", + "Hayashi K.", + "Sato H.", + "Nagai K.", + "Kimura K.", + "Makita H.", + "Sekine M.", + "Obayashi M.", + "Nishi T.", + "Shibahara T.", + "Tanaka T.", + "Ishii S.", + "Yamamoto J.", + "Saito K.", + "Kawai Y.", + "Isono Y.", + "Nakamura Y.", + "Nagahari K.", + "Murakami K.", + "Yasuda T.", + "Iwayanagi T.", + "Wagatsuma M.", + "Shiratori A.", + "Sudo H.", + "Hosoiri T.", + "Kaku Y.", + "Kodaira H.", + "Kondo H.", + "Sugawara M.", + "Takahashi M.", + "Kanda K.", + "Yokoi T.", + "Furuya T.", + "Kikkawa E.", + "Omura Y.", + "Abe K.", + "Kamihara K.", + "Katsuta N.", + "Sato K.", + "Tanikawa M.", + "Yamazaki M.", + "Ninomiya K.", + "Ishibashi T.", + "Yamashita H.", + "Murakawa K.", + "Fujimori K.", + "Tanai H.", + "Kimata M.", + "Watanabe M.", + "Hiraoka S.", + "Chiba Y.", + "Ishida S.", + "Ono Y.", + "Takiguchi S.", + "Watanabe S.", + "Yosida M.", + "Hotuta T.", + "Kusano J.", + "Kanehori K.", + "Takahashi-Fujii A.", + "Hara H.", + "Tanase T.-O.", + "Nomura Y.", + "Togiya S.", + "Komai F.", + "Hara R.", + "Takeuchi K.", + "Arita M.", + "Imose N.", + "Musashino K.", + "Yuuki H.", + "Oshima A.", + "Sasaki N.", + "Aotsuka S.", + "Yoshikawa Y.", + "Matsunawa H.", + "Ichihara T.", + "Shiohata N.", + "Sano S.", + "Moriya S.", + "Momiyama H.", + "Satoh N.", + "Takami S.", + "Terashima Y.", + "Suzuki O.", + "Nakagawa S.", + "Senoh A.", + "Mizoguchi H.", + "Goto Y.", + "Shimizu F.", + "Wakebe H.", + "Hishigaki H.", + "Watanabe T.", + "Sugiyama A.", + "Takemoto M.", + "Kawakami B.", + "Yamazaki M.", + "Watanabe K.", + "Kumagai A.", + "Itakura S.", + "Fukuzumi Y.", + "Fujimori Y.", + "Komiyama M.", + "Tashiro H.", + "Tanigami A.", + "Fujiwara T.", + "Ono T.", + "Yamada K.", + "Fujii Y.", + "Ozaki K.", + "Hirao M.", + "Ohmori Y.", + "Kawabata A.", + "Hikiji T.", + "Kobatake N.", + "Inagaki H.", + "Ikema Y.", + "Okamoto S.", + "Okitani R.", + "Kawakami T.", + "Noguchi S.", + "Itoh T.", + "Shigeta K.", + "Senba T.", + "Matsumura K.", + "Nakajima Y.", + "Mizuno T.", + "Morinaga M.", + "Sasaki M.", + "Togashi T.", + "Oyama M.", + "Hata H.", + "Watanabe M.", + "Komatsu T.", + "Mizushima-Sugano J.", + "Satoh T.", + "Shirai Y.", + "Takahashi Y.", + "Nakagawa K.", + "Okumura K.", + "Nagase T.", + "Nomura N.", + "Kikuchi H.", + "Masuho Y.", + "Yamashita R.", + "Nakai K.", + "Yada T.", + "Nakamura Y.", + "Ohara O.", + "Isogai T.", + "Sugano S." + ], + "publication": { + "journalName": "Nat. Genet." + }, + "location": { + "volume": "36", + "firstPage": "40", + "lastPage": "45" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "14702039" + }, + { + "type": "DOI", + "id": "10.1038/ng1285" + } + ] + }, + "source": { + "tissue": [ + { + "value": "Brain" + } + ] + }, + "scope": ["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"] + }, + { + "citation": { + "type": "submission", + "publicationDate": "APR-2005", + "authors": [ + "Suzuki Y.", + "Sugano S.", + "Totoki Y.", + "Toyoda A.", + "Takeda T.", + "Sakaki Y.", + "Tanaka A.", + "Yokoyama S." + ], + "publication": { + "submissionDatabase": "EMBL/GenBank/DDBJ databases" + } + }, + "source": { + "tissue": [ + { + "value": "Thyroid" + } + ] + }, + "scope": ["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]", "VARIANT GLN-27"] + }, + { + "citation": { + "type": "submission", + "publicationDate": "JUN-2005", + "consortiums": ["SeattleSNPs variation discovery resource"], + "publication": { + "submissionDatabase": "EMBL/GenBank/DDBJ databases" + } + }, + "scope": [ + "NUCLEOTIDE SEQUENCE [GENOMIC DNA]", + "VARIANTS GLN-27 AND CYS-220" + ] + }, + { + "citation": { + "type": "submission", + "publicationDate": "DEC-2007", + "consortiums": ["NHLBI resequencing and genotyping service (RS&G)"], + "publication": { + "submissionDatabase": "EMBL/GenBank/DDBJ databases" + } + }, + "scope": ["NUCLEOTIDE SEQUENCE [GENOMIC DNA]", "VARIANT GLN-27"] + }, + { + "citation": { + "type": "submission", + "publicationDate": "SEP-2005", + "authors": [ + "Mural R.J.", + "Istrail S.", + "Sutton G.G.", + "Florea L.", + "Halpern A.L.", + "Mobarry C.M.", + "Lippert R.", + "Walenz B.", + "Shatkay H.", + "Dew I.", + "Miller J.R.", + "Flanigan M.J.", + "Edwards N.J.", + "Bolanos R.", + "Fasulo D.", + "Halldorsson B.V.", + "Hannenhalli S.", + "Turner R.", + "Yooseph S.", + "Lu F.", + "Nusskern D.R.", + "Shue B.C.", + "Zheng X.H.", + "Zhong F.", + "Delcher A.L.", + "Huson D.H.", + "Kravitz S.A.", + "Mouchard L.", + "Reinert K.", + "Remington K.A.", + "Clark A.G.", + "Waterman M.S.", + "Eichler E.E.", + "Adams M.D.", + "Hunkapiller M.W.", + "Myers E.W.", + "Venter J.C." + ], + "publication": { + "submissionDatabase": "EMBL/GenBank/DDBJ databases" + } + }, + "scope": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2004", + "title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).", + "consortiums": ["The MGC Project Team"], + "publication": { + "journalName": "Genome Res." + }, + "location": { + "volume": "14", + "firstPage": "2121", + "lastPage": "2127" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "15489334" + }, + { + "type": "DOI", + "id": "10.1101/gr.2596504" + } + ] + }, + "source": { + "tissue": [ + { + "value": "Fetal brain" + }, + { + "value": "Leukocyte" + }, + { + "value": "Prostate" + } + ] + }, + "scope": [ + "NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]", + "VARIANTS ARG-16 AND GLN-27" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1988", + "title": "Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation.", + "authors": [ + "Chung F.-Z.", + "Wang C.-D.", + "Potter P.C.", + "Venter J.C.", + "Fraser C.M." + ], + "publication": { + "journalName": "J. Biol. Chem." + }, + "location": { + "volume": "263", + "firstPage": "4052", + "lastPage": "4055" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "2831218" + }, + { + "type": "DOI", + "id": "10.1016/s0021-9258(18)68888-x" + } + ] + }, + "scope": ["MUTAGENESIS OF ASP-79", "FUNCTION", "SUBCELLULAR LOCATION"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1989", + "title": "Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.", + "authors": [ + "O'Dowd B.F.", + "Hnatowich M.", + "Caron M.G.", + "Lefkowitz R.J.", + "Bouvier M." + ], + "publication": { + "journalName": "J. Biol. Chem." + }, + "location": { + "volume": "264", + "firstPage": "7564", + "lastPage": "7569" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "2540197" + }, + { + "type": "DOI", + "id": "10.1016/s0021-9258(18)83271-9" + } + ] + }, + "scope": ["PALMITOYLATION AT CYS-341", "MUTAGENESIS OF CYS-341"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1995", + "title": "Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.", + "authors": ["Valiquette M.", "Parent S.", "Loisel T.P.", "Bouvier M."], + "publication": { + "journalName": "EMBO J." + }, + "location": { + "volume": "14", + "firstPage": "5542", + "lastPage": "5549" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "8521811" + }, + { + "type": "DOI", + "id": "10.1002/j.1460-2075.1995.tb00241.x" + } + ] + }, + "scope": [ + "MUTAGENESIS OF TYR-141; TYR-350; TYR-354 AND TYR-366", + "PHOSPHORYLATION AT TYR-141" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1995", + "title": "Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors.", + "authors": [ + "Gurevich V.V.", + "Dion S.B.", + "Onorato J.J.", + "Ptasienski J.", + "Kim C.M.", + "Sterne-Marr R.", + "Hosey M.M.", + "Benovic J.L." + ], + "publication": { + "journalName": "J. Biol. Chem." + }, + "location": { + "volume": "270", + "firstPage": "720", + "lastPage": "731" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "7822302" + }, + { + "type": "DOI", + "id": "10.1074/jbc.270.2.720" + } + ] + }, + "scope": ["INTERACTION WITH ARRB1 AND ARRB2"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1997", + "title": "Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.", + "authors": [ + "Lin F.-T.", + "Krueger K.M.", + "Kendall H.E.", + "Daaka Y.", + "Fredericks Z.L.", + "Pitcher J.A.", + "Lefkowitz R.J." + ], + "publication": { + "journalName": "J. Biol. Chem." + }, + "location": { + "volume": "272", + "firstPage": "31051", + "lastPage": "31057" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "9388255" + }, + { + "type": "DOI", + "id": "10.1074/jbc.272.49.31051" + } + ] + }, + "scope": ["INTERACTION WITH ARRB1"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1999", + "title": "A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.", + "authors": [ + "Cao T.T.", + "Deacon H.W.", + "Reczek D.", + "Bretscher A.", + "von Zastrow M." + ], + "publication": { + "journalName": "Nature" + }, + "location": { + "volume": "401", + "firstPage": "286", + "lastPage": "290" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "10499588" + }, + { + "type": "DOI", + "id": "10.1038/45816" + } + ] + }, + "scope": ["INTERACTION WITH NHERF1"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1999", + "title": "Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.", + "authors": [ + "Luttrell L.M.", + "Ferguson S.S.G.", + "Daaka Y.", + "Miller W.E.", + "Maudsley S.", + "Della Rocca G.J.", + "Lin F.-T.", + "Kawakatsu H.", + "Owada K.", + "Luttrell D.K.", + "Caron M.G.", + "Lefkowitz R.J." + ], + "publication": { + "journalName": "Science" + }, + "location": { + "volume": "283", + "firstPage": "655", + "lastPage": "661" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "9924018" + }, + { + "type": "DOI", + "id": "10.1126/science.283.5402.655" + } + ] + }, + "scope": ["INTERACTION WITH SRC AND ARRB1"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2001", + "title": "The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization.", + "authors": ["Moffett S.", "Rousseau G.", "Lagace M.", "Bouvier M."], + "publication": { + "journalName": "J. Neurochem." + }, + "location": { + "volume": "76", + "firstPage": "269", + "lastPage": "279" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "11146000" + }, + { + "type": "DOI", + "id": "10.1046/j.1471-4159.2001.00005.x" + } + ] + }, + "scope": [ + "EFFECT OF PALMITOYLATION", + "PHOSPHORYLATION AT SER-345 AND SER-346", + "MUTAGENESIS OF 345-SER-SER-346" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2002", + "title": "Modulation of postendocytic sorting of G protein-coupled receptors.", + "authors": [ + "Whistler J.L.", + "Enquist J.", + "Marley A.", + "Fong J.", + "Gladher F.", + "Tsuruda P.", + "Murray S.R.", + "Von Zastrow M." + ], + "publication": { + "journalName": "Science" + }, + "location": { + "volume": "297", + "firstPage": "615", + "lastPage": "620" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "12142540" + }, + { + "type": "DOI", + "id": "10.1126/science.1073308" + } + ] + }, + "scope": ["INTERACTION WITH GPRASP1"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2007", + "title": "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.", + "authors": [ + "Matsuoka S.", + "Ballif B.A.", + "Smogorzewska A.", + "McDonald E.R. III", + "Hurov K.E.", + "Luo J.", + "Bakalarski C.E.", + "Zhao Z.", + "Solimini N.", + "Lerenthal Y.", + "Shiloh Y.", + "Gygi S.P.", + "Elledge S.J." + ], + "publication": { + "journalName": "Science" + }, + "location": { + "volume": "316", + "firstPage": "1160", + "lastPage": "1166" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "17525332" + }, + { + "type": "DOI", + "id": "10.1126/science.1140321" + } + ] + }, + "source": { + "tissue": [ + { + "value": "Embryonic kidney" + } + ] + }, + "scope": [ + "PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246", + "IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2009", + "title": "The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.", + "authors": [ + "Berthouze M.", + "Venkataramanan V.", + "Li Y.", + "Shenoy S.K." + ], + "publication": { + "journalName": "EMBO J." + }, + "location": { + "volume": "28", + "firstPage": "1684", + "lastPage": "1696" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "19424180" + }, + { + "type": "DOI", + "id": "10.1038/emboj.2009.128" + } + ] + }, + "scope": [ + "UBIQUITINATION", + "DEUBIQUITINATION BY USP20 AND USP33", + "INTERACTION WITH USP20 AND USP33" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2009", + "title": "Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.", + "authors": [ + "Xie L.", + "Xiao K.", + "Whalen E.J.", + "Forrester M.T.", + "Freeman R.S.", + "Fong G.", + "Gygi S.P.", + "Lefkowitz R.J.", + "Stamler J.S." + ], + "publication": { + "journalName": "Sci. Signal." + }, + "location": { + "volume": "2", + "firstPage": "RA33", + "lastPage": "RA33" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "19584355" + }, + { + "type": "DOI", + "id": "10.1126/scisignal.2000444" + } + ] + }, + "scope": [ + "INTERACTION WITH EGLN3 AND VHL", + "SUBCELLULAR LOCATION", + "INDUCTION", + "UBIQUITINATION", + "HYDROXYLATION AT PRO-382 AND PRO-395", + "IDENTIFICATION BY MASS SPECTROMETRY" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2010", + "title": "Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.", + "authors": ["Nabhan J.F.", "Pan H.", "Lu Q."], + "publication": { + "journalName": "EMBO Rep." + }, + "location": { + "volume": "11", + "firstPage": "605", + "lastPage": "611" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "20559325" + }, + { + "type": "DOI", + "id": "10.1038/embor.2010.80" + } + ] + }, + "scope": [ + "UBIQUITINATION", + "SUBCELLULAR LOCATION", + "INTERACTION WITH ARRDC3" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2010", + "title": "SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane.", + "authors": [ + "Lauffer B.E.", + "Melero C.", + "Temkin P.", + "Lei C.", + "Hong W.", + "Kortemme T.", + "von Zastrow M." + ], + "publication": { + "journalName": "J. Cell Biol." + }, + "location": { + "volume": "190", + "firstPage": "565", + "lastPage": "574" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "20733053" + }, + { + "type": "DOI", + "id": "10.1083/jcb.201004060" + } + ] + }, + "scope": ["INTERACTION WITH SNX27"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2011", + "title": "SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.", + "authors": [ + "Temkin P.", + "Lauffer B.", + "Jager S.", + "Cimermancic P.", + "Krogan N.J.", + "von Zastrow M." + ], + "publication": { + "journalName": "Nat. Cell Biol." + }, + "location": { + "volume": "13", + "firstPage": "715", + "lastPage": "721" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "21602791" + }, + { + "type": "DOI", + "id": "10.1038/ncb2252" + } + ] + }, + "scope": ["INTERACTION WITH SNX27"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2012", + "title": "MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors.", + "authors": [ + "Han S.O.", + "Xiao K.", + "Kim J.", + "Wu J.H.", + "Wisler J.W.", + "Nakamura N.", + "Freedman N.J.", + "Shenoy S.K." + ], + "publication": { + "journalName": "J. Cell Biol." + }, + "location": { + "volume": "199", + "firstPage": "817", + "lastPage": "830" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "23166351" + }, + { + "type": "DOI", + "id": "10.1083/jcb.201208192" + } + ] + }, + "scope": [ + "INTERACTION WITH MARCHF2; NEDD4; USP20 AND USP33", + "SUBCELLULAR LOCATION", + "UBIQUITINATION" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2014", + "title": "Insights into beta2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.", + "authors": ["Qi S.", "O'Hayre M.", "Gutkind J.S.", "Hurley J.H."], + "publication": { + "journalName": "Protein Sci." + }, + "location": { + "volume": "23", + "firstPage": "1708", + "lastPage": "1716" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "25220262" + }, + { + "type": "DOI", + "id": "10.1002/pro.2549" + } + ] + }, + "scope": ["SUBCELLULAR LOCATION", "INTERACTION WITH ARRDC3"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2014", + "title": "CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum.", + "authors": [ + "Sauvageau E.", + "Rochdi M.D.", + "Oueslati M.", + "Hamdan F.F.", + "Percherancier Y.", + "Simpson J.C.", + "Pepperkok R.", + "Bouvier M." + ], + "publication": { + "journalName": "Traffic" + }, + "location": { + "volume": "15", + "firstPage": "383", + "lastPage": "400" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "24405750" + }, + { + "type": "DOI", + "id": "10.1111/tra.12148" + } + ] + }, + "scope": ["INTERACTION WITH CNIH4"] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2016", + "title": "S-Palmitoylation of a Novel Site in the beta2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary.", + "authors": ["Adachi N.", "Hess D.T.", "McLaughlin P.", "Stamler J.S."], + "publication": { + "journalName": "J. Biol. Chem." + }, + "location": { + "volume": "291", + "firstPage": "20232", + "lastPage": "20246" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "27481942" + }, + { + "type": "DOI", + "id": "10.1074/jbc.m116.725762" + } + ] + }, + "scope": [ + "SUBCELLULAR LOCATION", + "PALMITOYLATION AT CYS-265 AND CYS-341", + "MUTAGENESIS OF CYS-265 AND CYS-341" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2007", + "title": "Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.", + "authors": [ + "Rasmussen S.G.F.", + "Choi H.-J.", + "Rosenbaum D.M.", + "Kobilka T.S.", + "Thian F.S.", + "Edwards P.C.", + "Burghammer M.", + "Ratnala V.R.P.", + "Sanishvili R.", + "Fischetti R.F.", + "Schertler G.F.X.", + "Weis W.I.", + "Kobilka B.K." + ], + "publication": { + "journalName": "Nature" + }, + "location": { + "volume": "450", + "firstPage": "383", + "lastPage": "387" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "17952055" + }, + { + "type": "DOI", + "id": "10.1038/nature06325" + } + ] + }, + "scope": [ + "X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 1-365 IN COMPLEX WITH CARAZOLOL", + "TOPOLOGY" + ], + "evidences": [ + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "2R4R", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2R4R" + } + }, + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "2R4S", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2R4S" + } + } + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2007", + "title": "High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.", + "authors": [ + "Cherezov V.", + "Rosenbaum D.M.", + "Hanson M.A.", + "Rasmussen S.G.F.", + "Thian F.S.", + "Kobilka T.S.", + "Choi H.-J.", + "Kuhn P.", + "Weis W.I.", + "Kobilka B.K.", + "Stevens R.C." + ], + "publication": { + "journalName": "Science" + }, + "location": { + "volume": "318", + "firstPage": "1258", + "lastPage": "1265" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "17962520" + }, + { + "type": "DOI", + "id": "10.1126/science.1150577" + } + ] + }, + "scope": [ + "X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-365 IN COMPLEX WITH CARAZOLOL AND CHOLESTEROL", + "DISULFIDE BONDS", + "TOPOLOGY", + "PALMITOYLATION AT CYS-341" + ], + "evidences": [ + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "2RH1", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/2RH1" + } + } + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "2008", + "title": "A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.", + "authors": [ + "Hanson M.A.", + "Cherezov V.", + "Griffith M.T.", + "Roth C.B.", + "Jaakola V.P.", + "Chien E.Y.", + "Velasquez J.", + "Kuhn P.", + "Stevens R.C." + ], + "publication": { + "journalName": "Structure" + }, + "location": { + "volume": "16", + "firstPage": "897", + "lastPage": "905" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "18547522" + }, + { + "type": "DOI", + "id": "10.1016/j.str.2008.05.001" + } + ] + }, + "scope": [ + "X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-365 IN COMPLEX WITH TIMOLOL AND CHOLESTEROL", + "DISULFIDE BONDS", + "TOPOLOGY", + "PALMITOYLATION AT CYS-341" + ], + "evidences": [ + { + "code": "ECO:0007744", + "source": { + "name": "PDB", + "id": "3D4S", + "url": "https://www.ebi.ac.uk/pdbe-srv/view/entry/3D4S" + } + } + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1994", + "title": "Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.", + "authors": ["Green S.A.", "Turki J.", "Innis M.", "Ligget S.B."], + "publication": { + "journalName": "Biochemistry" + }, + "location": { + "volume": "33", + "firstPage": "9414", + "lastPage": "9419" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "7915137" + }, + { + "type": "DOI", + "id": "10.1021/bi00198a006" + } + ] + }, + "scope": [ + "VARIANTS ARG-16 AND GLN-27", + "CHARACTERIZATION", + "FUNCTION", + "SUBCELLULAR LOCATION" + ] + }, + { + "citation": { + "type": "journal article", + "publicationDate": "1995", + "title": "Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.", + "authors": [ + "Turki J.", + "Pak J.", + "Green S.A.", + "Martin R.J.", + "Liggett S.B." + ], + "publication": { + "journalName": "J. Clin. Invest." + }, + "location": { + "volume": "95", + "firstPage": "1635", + "lastPage": "1641" + }, + "dbReferences": [ + { + "type": "PubMed", + "id": "7706471" + }, + { + "type": "DOI", + "id": "10.1172/jci117838" + } + ] + }, + "scope": ["VARIANT ARG-16", "POLYMORPHISM"] + } + ], + "sequence": { + "version": 3, + "length": 413, + "mass": 46459, + "modified": "2010-05-18", + "sequence": "MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL" + } +}