diff --git a/Cargo.lock b/Cargo.lock
new file mode 100644
index 0000000..5087408
--- /dev/null
+++ b/Cargo.lock
@@ -0,0 +1,1735 @@
+# This file is automatically @generated by Cargo.
+# It is not intended for manual editing.
+version = 3
+
+[[package]]
+name = "addr2line"
+version = "0.22.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "6e4503c46a5c0c7844e948c9a4d6acd9f50cccb4de1c48eb9e291ea17470c678"
+dependencies = [
+ "gimli",
+]
+
+[[package]]
+name = "adler"
+version = "1.0.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "f26201604c87b1e01bd3d98f8d5d9a8fcbb815e8cedb41ffccbeb4bf593a35fe"
+
+[[package]]
+name = "ahash"
+version = "0.8.11"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e89da841a80418a9b391ebaea17f5c112ffaaa96f621d2c285b5174da76b9011"
+dependencies = [
+ "cfg-if",
+ "once_cell",
+ "version_check",
+ "zerocopy 0.7.35",
+]
+
+[[package]]
+name = "aho-corasick"
+version = "1.1.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8e60d3430d3a69478ad0993f19238d2df97c507009a52b3c10addcd7f6bcb916"
+dependencies = [
+ "memchr",
+]
+
+[[package]]
+name = "anstream"
+version = "0.6.15"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "64e15c1ab1f89faffbf04a634d5e1962e9074f2741eef6d97f3c4e322426d526"
+dependencies = [
+ "anstyle",
+ "anstyle-parse",
+ "anstyle-query",
+ "anstyle-wincon",
+ "colorchoice",
+ "is_terminal_polyfill",
+ "utf8parse",
+]
+
+[[package]]
+name = "anstyle"
+version = "1.0.8"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "1bec1de6f59aedf83baf9ff929c98f2ad654b97c9510f4e70cf6f661d49fd5b1"
+
+[[package]]
+name = "anstyle-parse"
+version = "0.2.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "eb47de1e80c2b463c735db5b217a0ddc39d612e7ac9e2e96a5aed1f57616c1cb"
+dependencies = [
+ "utf8parse",
+]
+
+[[package]]
+name = "anstyle-query"
+version = "1.1.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "6d36fc52c7f6c869915e99412912f22093507da8d9e942ceaf66fe4b7c14422a"
+dependencies = [
+ "windows-sys",
+]
+
+[[package]]
+name = "anstyle-wincon"
+version = "3.0.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5bf74e1b6e971609db8ca7a9ce79fd5768ab6ae46441c572e46cf596f59e57f8"
+dependencies = [
+ "anstyle",
+ "windows-sys",
+]
+
+[[package]]
+name = "anyhow"
+version = "1.0.86"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b3d1d046238990b9cf5bcde22a3fb3584ee5cf65fb2765f454ed428c7a0063da"
+
+[[package]]
+name = "approx"
+version = "0.5.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "cab112f0a86d568ea0e627cc1d6be74a1e9cd55214684db5561995f6dad897c6"
+dependencies = [
+ "num-traits",
+]
+
+[[package]]
+name = "async-compression"
+version = "0.4.12"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "fec134f64e2bc57411226dfc4e52dec859ddfc7e711fc5e07b612584f000e4aa"
+dependencies = [
+ "flate2",
+ "futures-core",
+ "memchr",
+ "pin-project-lite",
+ "tokio",
+]
+
+[[package]]
+name = "autocfg"
+version = "1.3.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "0c4b4d0bd25bd0b74681c0ad21497610ce1b7c91b1022cd21c80c6fbdd9476b0"
+
+[[package]]
+name = "backtrace"
+version = "0.3.73"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5cc23269a4f8976d0a4d2e7109211a419fe30e8d88d677cd60b6bc79c5732e0a"
+dependencies = [
+ "addr2line",
+ "cc",
+ "cfg-if",
+ "libc",
+ "miniz_oxide",
+ "object",
+ "rustc-demangle",
+]
+
+[[package]]
+name = "bio"
+version = "2.0.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e8cbd545253762ecf9ef741f2c49f07c06a0ce4d041d74ee9c3f1ce0e2d5446e"
+dependencies = [
+ "anyhow",
+ "approx",
+ "bio-types",
+ "bit-set",
+ "bv",
+ "bytecount",
+ "csv",
+ "custom_derive",
+ "editdistancek",
+ "enum-map",
+ "fxhash",
+ "itertools",
+ "itertools-num",
+ "lazy_static",
+ "multimap",
+ "ndarray",
+ "newtype_derive",
+ "num-integer",
+ "num-traits",
+ "ordered-float",
+ "petgraph",
+ "rand",
+ "regex",
+ "serde",
+ "serde_derive",
+ "statrs",
+ "strum",
+ "strum_macros",
+ "thiserror",
+ "triple_accel",
+ "vec_map",
+]
+
+[[package]]
+name = "bio-types"
+version = "1.0.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "1cc7edd677651969cc262a8dfb870f0c2266c3ceeaf863d742982e39699ff460"
+dependencies = [
+ "derive-new",
+ "lazy_static",
+ "regex",
+ "strum_macros",
+ "thiserror",
+]
+
+[[package]]
+name = "bit-set"
+version = "0.8.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "08807e080ed7f9d5433fa9b275196cfc35414f66a0c79d864dc51a0d825231a3"
+dependencies = [
+ "bit-vec 0.8.0",
+]
+
+[[package]]
+name = "bit-vec"
+version = "0.7.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d2c54ff287cfc0a34f38a6b832ea1bd8e448a330b3e40a50859e6488bee07f22"
+
+[[package]]
+name = "bit-vec"
+version = "0.8.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5e764a1d40d510daf35e07be9eb06e75770908c27d411ee6c92109c9840eaaf7"
+
+[[package]]
+name = "bitflags"
+version = "2.6.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b048fb63fd8b5923fc5aa7b340d8e156aec7ec02f0c78fa8a6ddc2613f6f71de"
+
+[[package]]
+name = "block-buffer"
+version = "0.10.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "3078c7629b62d3f0439517fa394996acacc5cbc91c5a20d8c658e77abd503a71"
+dependencies = [
+ "generic-array",
+]
+
+[[package]]
+name = "bstr"
+version = "1.10.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "40723b8fb387abc38f4f4a37c09073622e41dd12327033091ef8950659e6dc0c"
+dependencies = [
+ "memchr",
+ "serde",
+]
+
+[[package]]
+name = "bv"
+version = "0.11.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8834bb1d8ee5dc048ee3124f2c7c1afcc6bc9aed03f11e9dfd8c69470a5db340"
+dependencies = [
+ "feature-probe",
+ "serde",
+]
+
+[[package]]
+name = "bytecount"
+version = "0.6.8"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5ce89b21cab1437276d2650d57e971f9d548a2d9037cc231abdc0562b97498ce"
+
+[[package]]
+name = "bytemuck"
+version = "1.16.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "102087e286b4677862ea56cf8fc58bb2cdfa8725c40ffb80fe3a008eb7f2fc83"
+
+[[package]]
+name = "byteorder"
+version = "1.5.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "1fd0f2584146f6f2ef48085050886acf353beff7305ebd1ae69500e27c67f64b"
+
+[[package]]
+name = "bytes"
+version = "1.7.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8318a53db07bb3f8dca91a600466bdb3f2eaadeedfdbcf02e1accbad9271ba50"
+
+[[package]]
+name = "bzip2"
+version = "0.4.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "bdb116a6ef3f6c3698828873ad02c3014b3c85cadb88496095628e3ef1e347f8"
+dependencies = [
+ "bzip2-sys",
+ "libc",
+]
+
+[[package]]
+name = "bzip2-sys"
+version = "0.1.11+1.0.8"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "736a955f3fa7875102d57c82b8cac37ec45224a07fd32d58f9f7a186b6cd4cdc"
+dependencies = [
+ "cc",
+ "libc",
+ "pkg-config",
+]
+
+[[package]]
+name = "cc"
+version = "1.1.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "26a5c3fd7bfa1ce3897a3a3501d362b2d87b7f2583ebcb4a949ec25911025cbc"
+
+[[package]]
+name = "cfg-if"
+version = "1.0.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "baf1de4339761588bc0619e3cbc0120ee582ebb74b53b4efbf79117bd2da40fd"
+
+[[package]]
+name = "clap"
+version = "4.5.13"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "0fbb260a053428790f3de475e304ff84cdbc4face759ea7a3e64c1edd938a7fc"
+dependencies = [
+ "clap_builder",
+ "clap_derive",
+]
+
+[[package]]
+name = "clap_builder"
+version = "4.5.13"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "64b17d7ea74e9f833c7dbf2cbe4fb12ff26783eda4782a8975b72f895c9b4d99"
+dependencies = [
+ "anstream",
+ "anstyle",
+ "clap_lex",
+ "strsim",
+]
+
+[[package]]
+name = "clap_derive"
+version = "4.5.13"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "501d359d5f3dcaf6ecdeee48833ae73ec6e42723a1e52419c79abf9507eec0a0"
+dependencies = [
+ "heck",
+ "proc-macro2",
+ "quote",
+ "syn",
+]
+
+[[package]]
+name = "clap_lex"
+version = "0.7.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "1462739cb27611015575c0c11df5df7601141071f07518d56fcc1be504cbec97"
+
+[[package]]
+name = "colorchoice"
+version = "1.0.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d3fd119d74b830634cea2a0f58bbd0d54540518a14397557951e79340abc28c0"
+
+[[package]]
+name = "cpufeatures"
+version = "0.2.12"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "53fe5e26ff1b7aef8bca9c6080520cfb8d9333c7568e1829cef191a9723e5504"
+dependencies = [
+ "libc",
+]
+
+[[package]]
+name = "crc32fast"
+version = "1.4.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a97769d94ddab943e4510d138150169a2758b5ef3eb191a9ee688de3e23ef7b3"
+dependencies = [
+ "cfg-if",
+]
+
+[[package]]
+name = "crossbeam-channel"
+version = "0.5.13"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "33480d6946193aa8033910124896ca395333cae7e2d1113d1fef6c3272217df2"
+dependencies = [
+ "crossbeam-utils",
+]
+
+[[package]]
+name = "crossbeam-utils"
+version = "0.8.20"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "22ec99545bb0ed0ea7bb9b8e1e9122ea386ff8a48c0922e43f36d45ab09e0e80"
+
+[[package]]
+name = "crypto-common"
+version = "0.1.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "1bfb12502f3fc46cca1bb51ac28df9d618d813cdc3d2f25b9fe775a34af26bb3"
+dependencies = [
+ "generic-array",
+ "typenum",
+]
+
+[[package]]
+name = "csv"
+version = "1.3.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "ac574ff4d437a7b5ad237ef331c17ccca63c46479e5b5453eb8e10bb99a759fe"
+dependencies = [
+ "csv-core",
+ "itoa",
+ "ryu",
+ "serde",
+]
+
+[[package]]
+name = "csv-core"
+version = "0.1.11"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5efa2b3d7902f4b634a20cae3c9c4e6209dc4779feb6863329607560143efa70"
+dependencies = [
+ "memchr",
+]
+
+[[package]]
+name = "custom_derive"
+version = "0.1.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "ef8ae57c4978a2acd8b869ce6b9ca1dfe817bff704c220209fdef2c0b75a01b9"
+
+[[package]]
+name = "derive-new"
+version = "0.6.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d150dea618e920167e5973d70ae6ece4385b7164e0d799fe7c122dd0a5d912ad"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn",
+]
+
+[[package]]
+name = "digest"
+version = "0.10.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9ed9a281f7bc9b7576e61468ba615a66a5c8cfdff42420a70aa82701a3b1e292"
+dependencies = [
+ "block-buffer",
+ "crypto-common",
+]
+
+[[package]]
+name = "editdistancek"
+version = "1.0.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "3e02df23d5b1c6f9e69fa603b890378123b93073df998a21e6e33b9db0a32613"
+
+[[package]]
+name = "either"
+version = "1.13.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "60b1af1c220855b6ceac025d3f6ecdd2b7c4894bfe9cd9bda4fbb4bc7c0d4cf0"
+
+[[package]]
+name = "enum-map"
+version = "2.7.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "6866f3bfdf8207509a033af1a75a7b08abda06bbaaeae6669323fd5a097df2e9"
+dependencies = [
+ "enum-map-derive",
+]
+
+[[package]]
+name = "enum-map-derive"
+version = "0.17.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "f282cfdfe92516eb26c2af8589c274c7c17681f5ecc03c18255fe741c6aa64eb"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn",
+]
+
+[[package]]
+name = "equivalent"
+version = "1.0.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5443807d6dff69373d433ab9ef5378ad8df50ca6298caf15de6e52e24aaf54d5"
+
+[[package]]
+name = "fallible-iterator"
+version = "0.3.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "2acce4a10f12dc2fb14a218589d4f1f62ef011b2d0cc4b3cb1bba8e94da14649"
+
+[[package]]
+name = "fallible-streaming-iterator"
+version = "0.1.9"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "7360491ce676a36bf9bb3c56c1aa791658183a54d2744120f27285738d90465a"
+
+[[package]]
+name = "feature-probe"
+version = "0.1.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "835a3dc7d1ec9e75e2b5fb4ba75396837112d2060b03f7d43bc1897c7f7211da"
+
+[[package]]
+name = "fixedbitset"
+version = "0.4.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "0ce7134b9999ecaf8bcd65542e436736ef32ddca1b3e06094cb6ec5755203b80"
+
+[[package]]
+name = "flate2"
+version = "1.0.30"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5f54427cfd1c7829e2a139fcefea601bf088ebca651d2bf53ebc600eac295dae"
+dependencies = [
+ "crc32fast",
+ "miniz_oxide",
+]
+
+[[package]]
+name = "futures"
+version = "0.3.30"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "645c6916888f6cb6350d2550b80fb63e734897a8498abe35cfb732b6487804b0"
+dependencies = [
+ "futures-channel",
+ "futures-core",
+ "futures-io",
+ "futures-sink",
+ "futures-task",
+ "futures-util",
+]
+
+[[package]]
+name = "futures-channel"
+version = "0.3.30"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "eac8f7d7865dcb88bd4373ab671c8cf4508703796caa2b1985a9ca867b3fcb78"
+dependencies = [
+ "futures-core",
+ "futures-sink",
+]
+
+[[package]]
+name = "futures-core"
+version = "0.3.30"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "dfc6580bb841c5a68e9ef15c77ccc837b40a7504914d52e47b8b0e9bbda25a1d"
+
+[[package]]
+name = "futures-io"
+version = "0.3.30"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a44623e20b9681a318efdd71c299b6b222ed6f231972bfe2f224ebad6311f0c1"
+
+[[package]]
+name = "futures-sink"
+version = "0.3.30"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9fb8e00e87438d937621c1c6269e53f536c14d3fbd6a042bb24879e57d474fb5"
+
+[[package]]
+name = "futures-task"
+version = "0.3.30"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "38d84fa142264698cdce1a9f9172cf383a0c82de1bddcf3092901442c4097004"
+
+[[package]]
+name = "futures-util"
+version = "0.3.30"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "3d6401deb83407ab3da39eba7e33987a73c3df0c82b4bb5813ee871c19c41d48"
+dependencies = [
+ "futures-channel",
+ "futures-core",
+ "futures-io",
+ "futures-sink",
+ "futures-task",
+ "memchr",
+ "pin-project-lite",
+ "pin-utils",
+ "slab",
+]
+
+[[package]]
+name = "fxhash"
+version = "0.2.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "c31b6d751ae2c7f11320402d34e41349dd1016f8d5d45e48c4312bc8625af50c"
+dependencies = [
+ "byteorder",
+]
+
+[[package]]
+name = "gen"
+version = "0.1.0"
+dependencies = [
+ "bio",
+ "clap",
+ "include_dir",
+ "noodles",
+ "petgraph",
+ "rusqlite",
+ "rusqlite_migration",
+ "sha2",
+]
+
+[[package]]
+name = "generic-array"
+version = "0.14.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "85649ca51fd72272d7821adaf274ad91c288277713d9c18820d8499a7ff69e9a"
+dependencies = [
+ "typenum",
+ "version_check",
+]
+
+[[package]]
+name = "getrandom"
+version = "0.2.15"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "c4567c8db10ae91089c99af84c68c38da3ec2f087c3f82960bcdbf3656b6f4d7"
+dependencies = [
+ "cfg-if",
+ "libc",
+ "wasi",
+]
+
+[[package]]
+name = "gimli"
+version = "0.29.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "40ecd4077b5ae9fd2e9e169b102c6c330d0605168eb0e8bf79952b256dbefffd"
+
+[[package]]
+name = "hashbrown"
+version = "0.14.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e5274423e17b7c9fc20b6e7e208532f9b19825d82dfd615708b70edd83df41f1"
+dependencies = [
+ "ahash",
+]
+
+[[package]]
+name = "hashlink"
+version = "0.9.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "6ba4ff7128dee98c7dc9794b6a411377e1404dba1c97deb8d1a55297bd25d8af"
+dependencies = [
+ "hashbrown",
+]
+
+[[package]]
+name = "heck"
+version = "0.5.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "2304e00983f87ffb38b55b444b5e3b60a884b5d30c0fca7d82fe33449bbe55ea"
+
+[[package]]
+name = "include_dir"
+version = "0.7.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "923d117408f1e49d914f1a379a309cffe4f18c05cf4e3d12e613a15fc81bd0dd"
+dependencies = [
+ "include_dir_macros",
+]
+
+[[package]]
+name = "include_dir_macros"
+version = "0.7.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "7cab85a7ed0bd5f0e76d93846e0147172bed2e2d3f859bcc33a8d9699cad1a75"
+dependencies = [
+ "proc-macro2",
+ "quote",
+]
+
+[[package]]
+name = "indexmap"
+version = "2.3.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "de3fc2e30ba82dd1b3911c8de1ffc143c74a914a14e99514d7637e3099df5ea0"
+dependencies = [
+ "equivalent",
+ "hashbrown",
+]
+
+[[package]]
+name = "is_terminal_polyfill"
+version = "1.70.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "7943c866cc5cd64cbc25b2e01621d07fa8eb2a1a23160ee81ce38704e97b8ecf"
+
+[[package]]
+name = "itertools"
+version = "0.13.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "413ee7dfc52ee1a4949ceeb7dbc8a33f2d6c088194d9f922fb8318faf1f01186"
+dependencies = [
+ "either",
+]
+
+[[package]]
+name = "itertools-num"
+version = "0.1.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a872a22f9e6f7521ca557660adb96dd830e54f0f490fa115bb55dd69d38b27e7"
+dependencies = [
+ "num-traits",
+]
+
+[[package]]
+name = "itoa"
+version = "1.0.11"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "49f1f14873335454500d59611f1cf4a4b0f786f9ac11f4312a78e4cf2566695b"
+
+[[package]]
+name = "lazy_static"
+version = "1.5.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "bbd2bcb4c963f2ddae06a2efc7e9f3591312473c50c6685e1f298068316e66fe"
+
+[[package]]
+name = "lexical-core"
+version = "0.8.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "2cde5de06e8d4c2faabc400238f9ae1c74d5412d03a7bd067645ccbc47070e46"
+dependencies = [
+ "lexical-parse-float",
+ "lexical-parse-integer",
+ "lexical-util",
+ "lexical-write-float",
+ "lexical-write-integer",
+]
+
+[[package]]
+name = "lexical-parse-float"
+version = "0.8.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "683b3a5ebd0130b8fb52ba0bdc718cc56815b6a097e28ae5a6997d0ad17dc05f"
+dependencies = [
+ "lexical-parse-integer",
+ "lexical-util",
+ "static_assertions",
+]
+
+[[package]]
+name = "lexical-parse-integer"
+version = "0.8.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "6d0994485ed0c312f6d965766754ea177d07f9c00c9b82a5ee62ed5b47945ee9"
+dependencies = [
+ "lexical-util",
+ "static_assertions",
+]
+
+[[package]]
+name = "lexical-util"
+version = "0.8.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5255b9ff16ff898710eb9eb63cb39248ea8a5bb036bea8085b1a767ff6c4e3fc"
+dependencies = [
+ "static_assertions",
+]
+
+[[package]]
+name = "lexical-write-float"
+version = "0.8.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "accabaa1c4581f05a3923d1b4cfd124c329352288b7b9da09e766b0668116862"
+dependencies = [
+ "lexical-util",
+ "lexical-write-integer",
+ "static_assertions",
+]
+
+[[package]]
+name = "lexical-write-integer"
+version = "0.8.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e1b6f3d1f4422866b68192d62f77bc5c700bee84f3069f2469d7bc8c77852446"
+dependencies = [
+ "lexical-util",
+ "static_assertions",
+]
+
+[[package]]
+name = "libc"
+version = "0.2.155"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "97b3888a4aecf77e811145cadf6eef5901f4782c53886191b2f693f24761847c"
+
+[[package]]
+name = "libm"
+version = "0.2.8"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "4ec2a862134d2a7d32d7983ddcdd1c4923530833c9f2ea1a44fc5fa473989058"
+
+[[package]]
+name = "libsqlite3-sys"
+version = "0.28.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "0c10584274047cb335c23d3e61bcef8e323adae7c5c8c760540f73610177fc3f"
+dependencies = [
+ "cc",
+ "pkg-config",
+ "vcpkg",
+]
+
+[[package]]
+name = "log"
+version = "0.4.22"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a7a70ba024b9dc04c27ea2f0c0548feb474ec5c54bba33a7f72f873a39d07b24"
+
+[[package]]
+name = "lzma-sys"
+version = "0.1.20"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5fda04ab3764e6cde78b9974eec4f779acaba7c4e84b36eca3cf77c581b85d27"
+dependencies = [
+ "cc",
+ "libc",
+ "pkg-config",
+]
+
+[[package]]
+name = "matrixmultiply"
+version = "0.3.9"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9380b911e3e96d10c1f415da0876389aaf1b56759054eeb0de7df940c456ba1a"
+dependencies = [
+ "autocfg",
+ "rawpointer",
+]
+
+[[package]]
+name = "md-5"
+version = "0.10.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d89e7ee0cfbedfc4da3340218492196241d89eefb6dab27de5df917a6d2e78cf"
+dependencies = [
+ "cfg-if",
+ "digest",
+]
+
+[[package]]
+name = "memchr"
+version = "2.7.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "78ca9ab1a0babb1e7d5695e3530886289c18cf2f87ec19a575a0abdce112e3a3"
+
+[[package]]
+name = "miniz_oxide"
+version = "0.7.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b8a240ddb74feaf34a79a7add65a741f3167852fba007066dcac1ca548d89c08"
+dependencies = [
+ "adler",
+]
+
+[[package]]
+name = "multimap"
+version = "0.10.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "defc4c55412d89136f966bbb339008b474350e5e6e78d2714439c386b3137a03"
+dependencies = [
+ "serde",
+]
+
+[[package]]
+name = "nalgebra"
+version = "0.32.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "7b5c17de023a86f59ed79891b2e5d5a94c705dbe904a5b5c9c952ea6221b03e4"
+dependencies = [
+ "approx",
+ "matrixmultiply",
+ "nalgebra-macros",
+ "num-complex",
+ "num-rational",
+ "num-traits",
+ "rand",
+ "rand_distr",
+ "simba",
+ "typenum",
+]
+
+[[package]]
+name = "nalgebra-macros"
+version = "0.2.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "254a5372af8fc138e36684761d3c0cdb758a4410e938babcff1c860ce14ddbfc"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn",
+]
+
+[[package]]
+name = "ndarray"
+version = "0.15.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "adb12d4e967ec485a5f71c6311fe28158e9d6f4bc4a447b474184d0f91a8fa32"
+dependencies = [
+ "matrixmultiply",
+ "num-complex",
+ "num-integer",
+ "num-traits",
+ "rawpointer",
+]
+
+[[package]]
+name = "newtype_derive"
+version = "0.1.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "ac8cd24d9f185bb7223958d8c1ff7a961b74b1953fd05dba7cc568a63b3861ec"
+dependencies = [
+ "rustc_version",
+]
+
+[[package]]
+name = "noodles"
+version = "0.78.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "81e0702ff73390d2b8f97751bc34cfedcd3f5d39b4e32875e4c64a32d8cc670b"
+dependencies = [
+ "noodles-bam",
+ "noodles-bcf",
+ "noodles-bgzf",
+ "noodles-cram",
+ "noodles-csi",
+ "noodles-fasta",
+ "noodles-fastq",
+ "noodles-gff",
+ "noodles-sam",
+ "noodles-tabix",
+ "noodles-vcf",
+]
+
+[[package]]
+name = "noodles-bam"
+version = "0.65.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "406d4768f21c73e3075c0c0d77a5b21bc8b8169c8f0963122607cc410427b727"
+dependencies = [
+ "bit-vec 0.7.0",
+ "bstr",
+ "byteorder",
+ "bytes",
+ "futures",
+ "indexmap",
+ "noodles-bgzf",
+ "noodles-core",
+ "noodles-csi",
+ "noodles-sam",
+ "tokio",
+]
+
+[[package]]
+name = "noodles-bcf"
+version = "0.58.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "f1f217d811dde790866d3c4902ef713f9dc5c4b96e51935571ddf68399f97ad6"
+dependencies = [
+ "byteorder",
+ "futures",
+ "indexmap",
+ "noodles-bgzf",
+ "noodles-core",
+ "noodles-csi",
+ "noodles-vcf",
+ "tokio",
+]
+
+[[package]]
+name = "noodles-bgzf"
+version = "0.32.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "2b2fba0f4a64cc897d9396d730a0c444d148daed7de31ad5904ecc673178fc9d"
+dependencies = [
+ "byteorder",
+ "bytes",
+ "crossbeam-channel",
+ "flate2",
+ "futures",
+ "pin-project-lite",
+ "tokio",
+ "tokio-util",
+]
+
+[[package]]
+name = "noodles-core"
+version = "0.15.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "c5a8c6b020d1205abef2b0fab4463a6c5ecc3c8f4d561ca8b0d1a42323376200"
+dependencies = [
+ "bstr",
+]
+
+[[package]]
+name = "noodles-cram"
+version = "0.66.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8c7f58d900eb9fa1f0ef1a4834a6f71bfa792b25b2fa3b02e582239089907909"
+dependencies = [
+ "async-compression",
+ "bitflags",
+ "bstr",
+ "byteorder",
+ "bytes",
+ "bzip2",
+ "flate2",
+ "futures",
+ "indexmap",
+ "md-5",
+ "noodles-bam",
+ "noodles-core",
+ "noodles-fasta",
+ "noodles-sam",
+ "pin-project-lite",
+ "tokio",
+ "xz2",
+]
+
+[[package]]
+name = "noodles-csi"
+version = "0.37.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e4bc8001c54f1d8e47e1ac6041a5f27edc99b68bacea3fade9c89059de285aea"
+dependencies = [
+ "bit-vec 0.7.0",
+ "byteorder",
+ "indexmap",
+ "noodles-bgzf",
+ "noodles-core",
+ "tokio",
+]
+
+[[package]]
+name = "noodles-fasta"
+version = "0.41.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d7a1662ac3ace299515c982a322e378bbeb4c1bd90fb098d823ef0f3a6abcc00"
+dependencies = [
+ "bstr",
+ "bytes",
+ "memchr",
+ "noodles-bgzf",
+ "noodles-core",
+ "tokio",
+]
+
+[[package]]
+name = "noodles-fastq"
+version = "0.13.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "c1edf1f924acddeee36304c444e242b9bda52ef9383dc2d7f008fca190753207"
+dependencies = [
+ "futures",
+ "memchr",
+ "tokio",
+]
+
+[[package]]
+name = "noodles-gff"
+version = "0.35.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "adef59012090b5694b58cad0e4426cd18af404803f942d02e664af607d89ee28"
+dependencies = [
+ "futures",
+ "indexmap",
+ "noodles-bgzf",
+ "noodles-core",
+ "noodles-csi",
+ "percent-encoding",
+ "tokio",
+]
+
+[[package]]
+name = "noodles-sam"
+version = "0.62.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b80efc627501962e2ff15411d1c011fa9cf3db1b47ddd13dceb1d1134068d5b7"
+dependencies = [
+ "bitflags",
+ "bstr",
+ "futures",
+ "indexmap",
+ "lexical-core",
+ "memchr",
+ "noodles-bgzf",
+ "noodles-core",
+ "noodles-csi",
+ "tokio",
+]
+
+[[package]]
+name = "noodles-tabix"
+version = "0.43.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "545e16e229b7f8734b0a2a36bd4c98a5b70128663b16b5201ddadc0d09c28d4a"
+dependencies = [
+ "bit-vec 0.7.0",
+ "byteorder",
+ "indexmap",
+ "noodles-bgzf",
+ "noodles-core",
+ "noodles-csi",
+ "tokio",
+]
+
+[[package]]
+name = "noodles-vcf"
+version = "0.61.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b6372f1df57c1826d083370b6eac586f331509feed15fd80dda306ef3e7ac68d"
+dependencies = [
+ "futures",
+ "indexmap",
+ "memchr",
+ "noodles-bgzf",
+ "noodles-core",
+ "noodles-csi",
+ "noodles-tabix",
+ "percent-encoding",
+ "pin-project-lite",
+ "tokio",
+]
+
+[[package]]
+name = "num-complex"
+version = "0.4.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "73f88a1307638156682bada9d7604135552957b7818057dcef22705b4d509495"
+dependencies = [
+ "num-traits",
+]
+
+[[package]]
+name = "num-integer"
+version = "0.1.46"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "7969661fd2958a5cb096e56c8e1ad0444ac2bbcd0061bd28660485a44879858f"
+dependencies = [
+ "num-traits",
+]
+
+[[package]]
+name = "num-rational"
+version = "0.4.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "f83d14da390562dca69fc84082e73e548e1ad308d24accdedd2720017cb37824"
+dependencies = [
+ "num-integer",
+ "num-traits",
+]
+
+[[package]]
+name = "num-traits"
+version = "0.2.19"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "071dfc062690e90b734c0b2273ce72ad0ffa95f0c74596bc250dcfd960262841"
+dependencies = [
+ "autocfg",
+ "libm",
+]
+
+[[package]]
+name = "object"
+version = "0.36.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "3f203fa8daa7bb185f760ae12bd8e097f63d17041dcdcaf675ac54cdf863170e"
+dependencies = [
+ "memchr",
+]
+
+[[package]]
+name = "once_cell"
+version = "1.19.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "3fdb12b2476b595f9358c5161aa467c2438859caa136dec86c26fdd2efe17b92"
+
+[[package]]
+name = "ordered-float"
+version = "4.2.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "4a91171844676f8c7990ce64959210cd2eaef32c2612c50f9fae9f8aaa6065a6"
+dependencies = [
+ "num-traits",
+]
+
+[[package]]
+name = "paste"
+version = "1.0.15"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "57c0d7b74b563b49d38dae00a0c37d4d6de9b432382b2892f0574ddcae73fd0a"
+
+[[package]]
+name = "percent-encoding"
+version = "2.3.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e3148f5046208a5d56bcfc03053e3ca6334e51da8dfb19b6cdc8b306fae3283e"
+
+[[package]]
+name = "petgraph"
+version = "0.6.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b4c5cc86750666a3ed20bdaf5ca2a0344f9c67674cae0515bec2da16fbaa47db"
+dependencies = [
+ "fixedbitset",
+ "indexmap",
+]
+
+[[package]]
+name = "pin-project-lite"
+version = "0.2.14"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "bda66fc9667c18cb2758a2ac84d1167245054bcf85d5d1aaa6923f45801bdd02"
+
+[[package]]
+name = "pin-utils"
+version = "0.1.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8b870d8c151b6f2fb93e84a13146138f05d02ed11c7e7c54f8826aaaf7c9f184"
+
+[[package]]
+name = "pkg-config"
+version = "0.3.30"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d231b230927b5e4ad203db57bbcbee2802f6bce620b1e4a9024a07d94e2907ec"
+
+[[package]]
+name = "ppv-lite86"
+version = "0.2.18"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "dee4364d9f3b902ef14fab8a1ddffb783a1cb6b4bba3bfc1fa3922732c7de97f"
+dependencies = [
+ "zerocopy 0.6.6",
+]
+
+[[package]]
+name = "proc-macro2"
+version = "1.0.86"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5e719e8df665df0d1c8fbfd238015744736151d4445ec0836b8e628aae103b77"
+dependencies = [
+ "unicode-ident",
+]
+
+[[package]]
+name = "quote"
+version = "1.0.36"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "0fa76aaf39101c457836aec0ce2316dbdc3ab723cdda1c6bd4e6ad4208acaca7"
+dependencies = [
+ "proc-macro2",
+]
+
+[[package]]
+name = "rand"
+version = "0.8.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "34af8d1a0e25924bc5b7c43c079c942339d8f0a8b57c39049bef581b46327404"
+dependencies = [
+ "libc",
+ "rand_chacha",
+ "rand_core",
+]
+
+[[package]]
+name = "rand_chacha"
+version = "0.3.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e6c10a63a0fa32252be49d21e7709d4d4baf8d231c2dbce1eaa8141b9b127d88"
+dependencies = [
+ "ppv-lite86",
+ "rand_core",
+]
+
+[[package]]
+name = "rand_core"
+version = "0.6.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "ec0be4795e2f6a28069bec0b5ff3e2ac9bafc99e6a9a7dc3547996c5c816922c"
+dependencies = [
+ "getrandom",
+]
+
+[[package]]
+name = "rand_distr"
+version = "0.4.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "32cb0b9bc82b0a0876c2dd994a7e7a2683d3e7390ca40e6886785ef0c7e3ee31"
+dependencies = [
+ "num-traits",
+ "rand",
+]
+
+[[package]]
+name = "rawpointer"
+version = "0.2.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "60a357793950651c4ed0f3f52338f53b2f809f32d83a07f72909fa13e4c6c1e3"
+
+[[package]]
+name = "regex"
+version = "1.10.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "4219d74c6b67a3654a9fbebc4b419e22126d13d2f3c4a07ee0cb61ff79a79619"
+dependencies = [
+ "aho-corasick",
+ "memchr",
+ "regex-automata",
+ "regex-syntax",
+]
+
+[[package]]
+name = "regex-automata"
+version = "0.4.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "38caf58cc5ef2fed281f89292ef23f6365465ed9a41b7a7754eb4e26496c92df"
+dependencies = [
+ "aho-corasick",
+ "memchr",
+ "regex-syntax",
+]
+
+[[package]]
+name = "regex-syntax"
+version = "0.8.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "7a66a03ae7c801facd77a29370b4faec201768915ac14a721ba36f20bc9c209b"
+
+[[package]]
+name = "rusqlite"
+version = "0.31.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b838eba278d213a8beaf485bd313fd580ca4505a00d5871caeb1457c55322cae"
+dependencies = [
+ "bitflags",
+ "fallible-iterator",
+ "fallible-streaming-iterator",
+ "hashlink",
+ "libsqlite3-sys",
+ "smallvec",
+]
+
+[[package]]
+name = "rusqlite_migration"
+version = "1.2.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "55709bc01054c69e2f1cefdc886642b5e6376a8db3c86f761be0c423eebf178b"
+dependencies = [
+ "include_dir",
+ "log",
+ "rusqlite",
+]
+
+[[package]]
+name = "rustc-demangle"
+version = "0.1.24"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "719b953e2095829ee67db738b3bfa9fa368c94900df327b3f07fe6e794d2fe1f"
+
+[[package]]
+name = "rustc_version"
+version = "0.1.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "c5f5376ea5e30ce23c03eb77cbe4962b988deead10910c372b226388b594c084"
+dependencies = [
+ "semver",
+]
+
+[[package]]
+name = "rustversion"
+version = "1.0.17"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "955d28af4278de8121b7ebeb796b6a45735dc01436d898801014aced2773a3d6"
+
+[[package]]
+name = "ryu"
+version = "1.0.18"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "f3cb5ba0dc43242ce17de99c180e96db90b235b8a9fdc9543c96d2209116bd9f"
+
+[[package]]
+name = "safe_arch"
+version = "0.7.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "c3460605018fdc9612bce72735cba0d27efbcd9904780d44c7e3a9948f96148a"
+dependencies = [
+ "bytemuck",
+]
+
+[[package]]
+name = "semver"
+version = "0.1.20"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d4f410fedcf71af0345d7607d246e7ad15faaadd49d240ee3b24e5dc21a820ac"
+
+[[package]]
+name = "serde"
+version = "1.0.204"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "bc76f558e0cbb2a839d37354c575f1dc3fdc6546b5be373ba43d95f231bf7c12"
+dependencies = [
+ "serde_derive",
+]
+
+[[package]]
+name = "serde_derive"
+version = "1.0.204"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e0cd7e117be63d3c3678776753929474f3b04a43a080c744d6b0ae2a8c28e222"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn",
+]
+
+[[package]]
+name = "sha2"
+version = "0.10.8"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "793db75ad2bcafc3ffa7c68b215fee268f537982cd901d132f89c6343f3a3dc8"
+dependencies = [
+ "cfg-if",
+ "cpufeatures",
+ "digest",
+]
+
+[[package]]
+name = "simba"
+version = "0.8.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "061507c94fc6ab4ba1c9a0305018408e312e17c041eb63bef8aa726fa33aceae"
+dependencies = [
+ "approx",
+ "num-complex",
+ "num-traits",
+ "paste",
+ "wide",
+]
+
+[[package]]
+name = "slab"
+version = "0.4.9"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8f92a496fb766b417c996b9c5e57daf2f7ad3b0bebe1ccfca4856390e3d3bb67"
+dependencies = [
+ "autocfg",
+]
+
+[[package]]
+name = "smallvec"
+version = "1.13.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "3c5e1a9a646d36c3599cd173a41282daf47c44583ad367b8e6837255952e5c67"
+
+[[package]]
+name = "static_assertions"
+version = "1.1.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a2eb9349b6444b326872e140eb1cf5e7c522154d69e7a0ffb0fb81c06b37543f"
+
+[[package]]
+name = "statrs"
+version = "0.17.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "f697a07e4606a0a25c044de247e583a330dbb1731d11bc7350b81f48ad567255"
+dependencies = [
+ "approx",
+ "nalgebra",
+ "num-traits",
+ "rand",
+]
+
+[[package]]
+name = "strsim"
+version = "0.11.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "7da8b5736845d9f2fcb837ea5d9e2628564b3b043a70948a3f0b778838c5fb4f"
+
+[[package]]
+name = "strum"
+version = "0.26.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8fec0f0aef304996cf250b31b5a10dee7980c85da9d759361292b8bca5a18f06"
+
+[[package]]
+name = "strum_macros"
+version = "0.26.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "4c6bee85a5a24955dc440386795aa378cd9cf82acd5f764469152d2270e581be"
+dependencies = [
+ "heck",
+ "proc-macro2",
+ "quote",
+ "rustversion",
+ "syn",
+]
+
+[[package]]
+name = "syn"
+version = "2.0.72"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "dc4b9b9bf2add8093d3f2c0204471e951b2285580335de42f9d2534f3ae7a8af"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "unicode-ident",
+]
+
+[[package]]
+name = "thiserror"
+version = "1.0.63"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "c0342370b38b6a11b6cc11d6a805569958d54cfa061a29969c3b5ce2ea405724"
+dependencies = [
+ "thiserror-impl",
+]
+
+[[package]]
+name = "thiserror-impl"
+version = "1.0.63"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a4558b58466b9ad7ca0f102865eccc95938dca1a74a856f2b57b6629050da261"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn",
+]
+
+[[package]]
+name = "tokio"
+version = "1.39.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "daa4fb1bc778bd6f04cbfc4bb2d06a7396a8f299dc33ea1900cedaa316f467b1"
+dependencies = [
+ "backtrace",
+ "bytes",
+ "pin-project-lite",
+]
+
+[[package]]
+name = "tokio-util"
+version = "0.7.11"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9cf6b47b3771c49ac75ad09a6162f53ad4b8088b76ac60e8ec1455b31a189fe1"
+dependencies = [
+ "bytes",
+ "futures-core",
+ "futures-sink",
+ "pin-project-lite",
+ "tokio",
+]
+
+[[package]]
+name = "triple_accel"
+version = "0.4.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "22048bc95dfb2ffd05b1ff9a756290a009224b60b2f0e7525faeee7603851e63"
+
+[[package]]
+name = "typenum"
+version = "1.17.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "42ff0bf0c66b8238c6f3b578df37d0b7848e55df8577b3f74f92a69acceeb825"
+
+[[package]]
+name = "unicode-ident"
+version = "1.0.12"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "3354b9ac3fae1ff6755cb6db53683adb661634f67557942dea4facebec0fee4b"
+
+[[package]]
+name = "utf8parse"
+version = "0.2.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "06abde3611657adf66d383f00b093d7faecc7fa57071cce2578660c9f1010821"
+
+[[package]]
+name = "vcpkg"
+version = "0.2.15"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "accd4ea62f7bb7a82fe23066fb0957d48ef677f6eeb8215f372f52e48bb32426"
+
+[[package]]
+name = "vec_map"
+version = "0.8.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "f1bddf1187be692e79c5ffeab891132dfb0f236ed36a43c7ed39f1165ee20191"
+dependencies = [
+ "serde",
+]
+
+[[package]]
+name = "version_check"
+version = "0.9.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "0b928f33d975fc6ad9f86c8f283853ad26bdd5b10b7f1542aa2fa15e2289105a"
+
+[[package]]
+name = "wasi"
+version = "0.11.0+wasi-snapshot-preview1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9c8d87e72b64a3b4db28d11ce29237c246188f4f51057d65a7eab63b7987e423"
+
+[[package]]
+name = "wide"
+version = "0.7.26"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "901e8597c777fa042e9e245bd56c0dc4418c5db3f845b6ff94fbac732c6a0692"
+dependencies = [
+ "bytemuck",
+ "safe_arch",
+]
+
+[[package]]
+name = "windows-sys"
+version = "0.52.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "282be5f36a8ce781fad8c8ae18fa3f9beff57ec1b52cb3de0789201425d9a33d"
+dependencies = [
+ "windows-targets",
+]
+
+[[package]]
+name = "windows-targets"
+version = "0.52.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9b724f72796e036ab90c1021d4780d4d3d648aca59e491e6b98e725b84e99973"
+dependencies = [
+ "windows_aarch64_gnullvm",
+ "windows_aarch64_msvc",
+ "windows_i686_gnu",
+ "windows_i686_gnullvm",
+ "windows_i686_msvc",
+ "windows_x86_64_gnu",
+ "windows_x86_64_gnullvm",
+ "windows_x86_64_msvc",
+]
+
+[[package]]
+name = "windows_aarch64_gnullvm"
+version = "0.52.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "32a4622180e7a0ec044bb555404c800bc9fd9ec262ec147edd5989ccd0c02cd3"
+
+[[package]]
+name = "windows_aarch64_msvc"
+version = "0.52.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "09ec2a7bb152e2252b53fa7803150007879548bc709c039df7627cabbd05d469"
+
+[[package]]
+name = "windows_i686_gnu"
+version = "0.52.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8e9b5ad5ab802e97eb8e295ac6720e509ee4c243f69d781394014ebfe8bbfa0b"
+
+[[package]]
+name = "windows_i686_gnullvm"
+version = "0.52.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "0eee52d38c090b3caa76c563b86c3a4bd71ef1a819287c19d586d7334ae8ed66"
+
+[[package]]
+name = "windows_i686_msvc"
+version = "0.52.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "240948bc05c5e7c6dabba28bf89d89ffce3e303022809e73deaefe4f6ec56c66"
+
+[[package]]
+name = "windows_x86_64_gnu"
+version = "0.52.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "147a5c80aabfbf0c7d901cb5895d1de30ef2907eb21fbbab29ca94c5b08b1a78"
+
+[[package]]
+name = "windows_x86_64_gnullvm"
+version = "0.52.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "24d5b23dc417412679681396f2b49f3de8c1473deb516bd34410872eff51ed0d"
+
+[[package]]
+name = "windows_x86_64_msvc"
+version = "0.52.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "589f6da84c646204747d1270a2a5661ea66ed1cced2631d546fdfb155959f9ec"
+
+[[package]]
+name = "xz2"
+version = "0.1.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "388c44dc09d76f1536602ead6d325eb532f5c122f17782bd57fb47baeeb767e2"
+dependencies = [
+ "lzma-sys",
+]
+
+[[package]]
+name = "zerocopy"
+version = "0.6.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "854e949ac82d619ee9a14c66a1b674ac730422372ccb759ce0c39cabcf2bf8e6"
+dependencies = [
+ "byteorder",
+ "zerocopy-derive 0.6.6",
+]
+
+[[package]]
+name = "zerocopy"
+version = "0.7.35"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "1b9b4fd18abc82b8136838da5d50bae7bdea537c574d8dc1a34ed098d6c166f0"
+dependencies = [
+ "zerocopy-derive 0.7.35",
+]
+
+[[package]]
+name = "zerocopy-derive"
+version = "0.6.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "125139de3f6b9d625c39e2efdd73d41bdac468ccd556556440e322be0e1bbd91"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn",
+]
+
+[[package]]
+name = "zerocopy-derive"
+version = "0.7.35"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "fa4f8080344d4671fb4e831a13ad1e68092748387dfc4f55e356242fae12ce3e"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn",
+]
diff --git a/src/models/block.rs b/src/models/block.rs
index e140a53..4ffa70f 100644
--- a/src/models/block.rs
+++ b/src/models/block.rs
@@ -131,8 +131,7 @@ impl Block {
         phased: i32,
     ) -> Option<(Block, Block)> {
         if coordinate < block.start || coordinate >= block.end {
-            println!("Coordinate is out of block bounds");
-            return None;
+            panic!("Coordinate {coordinate} is out of block bounds");
         }
         let new_left_block = Block::create(
             conn,
@@ -208,6 +207,62 @@ impl Block {
         }
         objs
     }
+
+    pub fn create_prefix_block(conn: &Connection, block: Block, coordinate: i32) -> Block {
+        if coordinate < block.start || coordinate >= block.end {
+            panic!("Coordinate {coordinate} is out of block bounds");
+        }
+        let prefix_block = Block::create(
+            conn,
+            &block.sequence_hash,
+            block.block_group_id,
+            block.start,
+            coordinate,
+            &block.strand,
+        );
+
+        let edges_into = Block::edges_into(conn, block.id);
+
+        for edge in edges_into.iter() {
+            Edge::create(
+                conn,
+                edge.source_id,
+                Some(prefix_block.id),
+                edge.chromosome_index,
+                edge.phased,
+            );
+        }
+
+        prefix_block
+    }
+
+    pub fn create_suffix_block(conn: &Connection, block: Block, coordinate: i32) -> Block {
+        if coordinate < block.start || coordinate >= block.end {
+            panic!("Coordinate {coordinate} is out of block bounds");
+        }
+        let suffix_block = Block::create(
+            conn,
+            &block.sequence_hash,
+            block.block_group_id,
+            coordinate,
+            block.end,
+            &block.strand,
+        );
+
+        let edges_out_of = Block::edges_out_of(conn, block.id);
+
+        for edge in edges_out_of.iter() {
+            Edge::create(
+                conn,
+                Some(suffix_block.id),
+                edge.target_id,
+                edge.chromosome_index,
+                edge.phased,
+            );
+        }
+
+        suffix_block
+    }
 }
 
 #[cfg(test)]
@@ -508,6 +563,7 @@ mod tests {
     }
 
     #[test]
+    #[should_panic]
     fn test_split_block_bad_coordinate() {
         let conn = &mut get_connection();
         Collection::create(conn, &"test collection".to_string());
@@ -541,4 +597,138 @@ mod tests {
         let result = Block::split(conn, &block2, 100, 0, 0);
         assert!(result.is_none());
     }
+
+    #[test]
+    fn test_create_prefix_block() {
+        let conn = &mut get_connection();
+        Collection::create(conn, &"test collection".to_string());
+        let block_group = BlockGroup::create(
+            conn,
+            &"test collection".to_string(),
+            None,
+            &"test block group".to_string(),
+        );
+        let sequence1_hash =
+            Sequence::create(conn, "DNA".to_string(), &"ATCGATCG".to_string(), true);
+        let block1 = Block::create(
+            conn,
+            &sequence1_hash,
+            block_group.id,
+            0,
+            8,
+            &"+".to_string(),
+        );
+        let sequence2_hash =
+            Sequence::create(conn, "DNA".to_string(), &"AAAAAAAA".to_string(), true);
+        let block2 = Block::create(
+            conn,
+            &sequence2_hash,
+            block_group.id,
+            1,
+            8,
+            &"+".to_string(),
+        );
+        let sequence3_hash =
+            Sequence::create(conn, "DNA".to_string(), &"CCCCCCCC".to_string(), true);
+        let block3 = Block::create(
+            conn,
+            &sequence3_hash,
+            block_group.id,
+            1,
+            8,
+            &"+".to_string(),
+        );
+        let sequence4_hash =
+            Sequence::create(conn, "DNA".to_string(), &"GGGGGGGG".to_string(), true);
+        let block4 = Block::create(
+            conn,
+            &sequence4_hash,
+            block_group.id,
+            1,
+            8,
+            &"+".to_string(),
+        );
+        let edge1 = Edge::create(conn, Some(block1.id), Some(block3.id), 0, 0);
+        let edge2 = Edge::create(conn, Some(block2.id), Some(block3.id), 0, 0);
+        let edge3 = Edge::create(conn, Some(block3.id), Some(block4.id), 0, 0);
+
+        let prefix_block = Block::create_prefix_block(conn, block3, 4);
+
+        let edges_into_prefix_block = Block::edges_into(conn, prefix_block.id);
+        assert_eq!(edges_into_prefix_block.len(), 2);
+
+        let mut actual_previous_block_ids = HashSet::new();
+        actual_previous_block_ids.insert(edges_into_prefix_block[0].source_id.unwrap());
+        actual_previous_block_ids.insert(edges_into_prefix_block[1].source_id.unwrap());
+        let mut expected_previous_block_ids = HashSet::new();
+        expected_previous_block_ids.insert(block1.id);
+        expected_previous_block_ids.insert(block2.id);
+        assert_eq!(actual_previous_block_ids, expected_previous_block_ids);
+
+        let edges_out_of_prefix_block = Block::edges_out_of(conn, prefix_block.id);
+        assert_eq!(edges_out_of_prefix_block.len(), 0);
+    }
+    #[test]
+    fn test_create_suffix_block() {
+        let conn = &mut get_connection();
+        Collection::create(conn, &"test collection".to_string());
+        let block_group = BlockGroup::create(
+            conn,
+            &"test collection".to_string(),
+            None,
+            &"test block group".to_string(),
+        );
+        let sequence1_hash =
+            Sequence::create(conn, "DNA".to_string(), &"ATCGATCG".to_string(), true);
+        let block1 = Block::create(
+            conn,
+            &sequence1_hash,
+            block_group.id,
+            0,
+            8,
+            &"+".to_string(),
+        );
+        let sequence2_hash =
+            Sequence::create(conn, "DNA".to_string(), &"AAAAAAAA".to_string(), true);
+        let block2 = Block::create(
+            conn,
+            &sequence2_hash,
+            block_group.id,
+            1,
+            8,
+            &"+".to_string(),
+        );
+        let sequence3_hash =
+            Sequence::create(conn, "DNA".to_string(), &"CCCCCCCC".to_string(), true);
+        let block3 = Block::create(
+            conn,
+            &sequence3_hash,
+            block_group.id,
+            1,
+            8,
+            &"+".to_string(),
+        );
+        let sequence4_hash =
+            Sequence::create(conn, "DNA".to_string(), &"GGGGGGGG".to_string(), true);
+        let block4 = Block::create(
+            conn,
+            &sequence4_hash,
+            block_group.id,
+            1,
+            8,
+            &"+".to_string(),
+        );
+        let edge1 = Edge::create(conn, Some(block1.id), Some(block3.id), 0, 0);
+        let edge2 = Edge::create(conn, Some(block2.id), Some(block3.id), 0, 0);
+        let edge3 = Edge::create(conn, Some(block3.id), Some(block4.id), 0, 0);
+
+        let suffix_block = Block::create_suffix_block(conn, block3, 4);
+
+        let edges_into_suffix_block = Block::edges_into(conn, suffix_block.id);
+        assert_eq!(edges_into_suffix_block.len(), 0);
+
+        let edges_out_of_suffix_block = Block::edges_out_of(conn, suffix_block.id);
+        assert_eq!(edges_out_of_suffix_block.len(), 1);
+        assert_eq!(edges_out_of_suffix_block[0].target_id.unwrap(), block4.id);
+    }
 }
diff --git a/test.db b/test.db
new file mode 100644
index 0000000..119ce71
Binary files /dev/null and b/test.db differ