diff --git a/requirements.in b/requirements.in
index fc673ed6..020d85c5 100644
--- a/requirements.in
+++ b/requirements.in
@@ -4,7 +4,7 @@ cffi==1.15.0
 future==0.18.2
 itsdangerous==2.0.1
 pbr==1.10.0
-protobuf==3.19.4
+protobuf==4.22.0
 pyopenssl==19.1.0
 PyYAML==5.2 # PyYAML 5.3 does not support Python 3.4
 pytz==2021.3
diff --git a/requirements.txt b/requirements.txt
index 090690a4..be2c1ae7 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -30,7 +30,7 @@ itsdangerous==2.0.1
     # via -r requirements.in
 pbr==1.10.0
     # via -r requirements.in
-protobuf==3.19.4
+protobuf==4.22.0
     # via -r requirements.in
 pycparser==2.18
     # via cffi
diff --git a/setup.py b/setup.py
index 5a3982cd..99c3b316 100644
--- a/setup.py
+++ b/setup.py
@@ -20,7 +20,7 @@
     install_requires=[
         "deprecated==1.2.13",
         "cryptography>=2.2.1",
-        "protobuf==3.13.0",
+        "protobuf==4.22.0",
         "requests>=2.11.1",
         "future>=0.18.2",
         "asn1==2.2.0",