diff --git a/.github/workflows/checks.yml b/.github/workflows/checks.yml
index 96aeaa13e3..b9a797ad58 100644
--- a/.github/workflows/checks.yml
+++ b/.github/workflows/checks.yml
@@ -142,11 +142,12 @@ jobs:
           comment_tag: build-options
           GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
 
-  cypress-run:
-    name: End-to-end tests
+  e2e-run:
+    name: End-to-end tests, GeoNetwork v${{ matrix.gn_version }}
     runs-on: ubuntu-latest
-    outputs:
-      screenshotsUrl: ${{ steps.upload-screenshots.outputs.artifact-url }}
+    strategy:
+      matrix:
+        gn_version: [4.2.2, 4.2.8, 4.4.0]
     steps:
       - uses: actions/checkout@v4
 
@@ -156,24 +157,32 @@ jobs:
           node-version: ${{ env.NODE_VERSION }}
           cache: 'npm'
 
+      - name: Derive appropriate SHAs for base and head for `nx affected` commands
+        uses: nrwl/nx-set-shas@v2
+        with:
+          main-branch-name: 'main'
+
       - name: Create pipeline docker image
         run: cd tools && docker build . -f pipelines/Dockerfile -t geonetwork/geonetwork-ui-tools-pipelines:latest
 
-      - name: Build the backend
-        run: sudo docker-compose -f support-services/docker-compose.yml up -d init
+      - name: Start up backend support services
+        env:
+          GEONETWORK_VERSION: ${{ matrix.gn_version }}
+        working-directory: support-services
+        run: docker compose up -d init
 
       - name: Install dependencies
         run: |
           npm ci
 
-      - name: Run tests
-        run: npx nx run-many --target=e2e
+      - name: Run e2e tests
+        run: npx nx affected --target=e2e --parallel=3
 
       - uses: actions/upload-artifact@v4
         if: always()
         id: upload-screenshots
         with:
-          name: cypress-screenshots
+          name: cypress-screenshots-gn-${{ matrix.gn_version }}
           path: |
             apps/datahub-e2e/cypress/screenshots/**/*
             apps/metadata-editor-e2e/cypress/screenshots/**/*