diff --git a/cmd/zdb/zdb.c b/cmd/zdb/zdb.c
index d81199765c69..1eeb6e9116aa 100644
--- a/cmd/zdb/zdb.c
+++ b/cmd/zdb/zdb.c
@@ -5217,7 +5217,7 @@ dump_label(const char *dev)
 	    sizeof (cksum_record_t), offsetof(cksum_record_t, link));
 
 	psize = statbuf.st_size;
-	psize = P2ALIGN(psize, (uint64_t)sizeof (vdev_label_t));
+	psize = P2ALIGN_TYPED(psize, sizeof (vdev_label_t), uint64_t);
 	ashift = SPA_MINBLOCKSHIFT;
 
 	/*
diff --git a/cmd/ztest.c b/cmd/ztest.c
index 34744d12b592..ca3105ffbbbe 100644
--- a/cmd/ztest.c
+++ b/cmd/ztest.c
@@ -2448,7 +2448,7 @@ ztest_get_data(void *arg, uint64_t arg2, lr_write_t *lr, char *buf,
 		ASSERT3P(zio, !=, NULL);
 		size = doi.doi_data_block_size;
 		if (ISP2(size)) {
-			offset = P2ALIGN(offset, size);
+			offset = P2ALIGN_TYPED(offset, size, uint64_t);
 		} else {
 			ASSERT3U(offset, <, size);
 			offset = 0;
@@ -4668,7 +4668,8 @@ ztest_dmu_object_next_chunk(ztest_ds_t *zd, uint64_t id)
 	 */
 	mutex_enter(&os->os_obj_lock);
 	object = ztest_random(os->os_obj_next_chunk);
-	os->os_obj_next_chunk = P2ALIGN(object, dnodes_per_chunk);
+	os->os_obj_next_chunk = P2ALIGN_TYPED(object, dnodes_per_chunk,
+	    uint64_t);
 	mutex_exit(&os->os_obj_lock);
 }
 
@@ -6284,7 +6285,8 @@ ztest_fault_inject(ztest_ds_t *zd, uint64_t id)
 		 * the end of the disk (vdev_psize) is aligned to
 		 * sizeof (vdev_label_t).
 		 */
-		uint64_t psize = P2ALIGN(fsize, sizeof (vdev_label_t));
+		uint64_t psize = P2ALIGN_TYPED(fsize, sizeof (vdev_label_t),
+		    uint64_t);
 		if ((leaf & 1) == 1 &&
 		    offset + sizeof (bad) > psize - VDEV_LABEL_END_SIZE)
 			continue;
@@ -6600,8 +6602,8 @@ ztest_fletcher_incr(ztest_ds_t *zd, uint64_t id)
 				size_t inc = 64 * ztest_random(size / 67);
 				/* sometimes add few bytes to test non-simd */
 				if (ztest_random(100) < 10)
-					inc += P2ALIGN(ztest_random(64),
-					    sizeof (uint32_t));
+					inc += P2ALIGN_TYPED(ztest_random(64),
+					    sizeof (uint32_t), uint64_t);
 
 				if (inc > (size - pos))
 					inc = size - pos;
diff --git a/include/os/freebsd/spl/sys/ccompile.h b/include/os/freebsd/spl/sys/ccompile.h
index 26cf4db87aea..bebeb0db2452 100644
--- a/include/os/freebsd/spl/sys/ccompile.h
+++ b/include/os/freebsd/spl/sys/ccompile.h
@@ -138,7 +138,8 @@ typedef int enum_t;
 #define	readdir64 readdir
 #define	dirent64 dirent
 #endif
-#define	P2ALIGN(x, align)		((x) & -(align))
+// Deprecated. Use P2ALIGN_TYPED instead.
+// #define	P2ALIGN(x, align)		((x) & -(align))
 #define	P2CROSS(x, y, align)	(((x) ^ (y)) > (align) - 1)
 #define	P2ROUNDUP(x, align)		((((x) - 1) | ((align) - 1)) + 1)
 #define	P2PHASE(x, align)		((x) & ((align) - 1))
diff --git a/include/os/freebsd/spl/sys/sysmacros.h b/include/os/freebsd/spl/sys/sysmacros.h
index 3e8841ae66bd..2c9f4438d769 100644
--- a/include/os/freebsd/spl/sys/sysmacros.h
+++ b/include/os/freebsd/spl/sys/sysmacros.h
@@ -191,7 +191,8 @@ extern unsigned char bcd_to_byte[256];
  * eg, P2ALIGN(0x1234, 0x100) == 0x1200 (0x12*align)
  * eg, P2ALIGN(0x5600, 0x100) == 0x5600 (0x56*align)
  */
-#define	P2ALIGN(x, align)		((x) & -(align))
+// Deprecated. Use P2ALIGN_TYPED instead.
+// #define	P2ALIGN(x, align)		((x) & -(align))
 
 /*
  * return x % (mod) align
diff --git a/include/os/linux/spl/sys/sysmacros.h b/include/os/linux/spl/sys/sysmacros.h
index 99e3a6fb41c6..0e8390736309 100644
--- a/include/os/linux/spl/sys/sysmacros.h
+++ b/include/os/linux/spl/sys/sysmacros.h
@@ -159,7 +159,8 @@ makedev(unsigned int major, unsigned int minor)
 /*
  * Compatibility macros/typedefs needed for Solaris -> Linux port
  */
-#define	P2ALIGN(x, align)	((x) & -(align))
+// Deprecated. Use P2ALIGN_TYPED instead.
+// #define	P2ALIGN(x, align)	((x) & -(align))
 #define	P2CROSS(x, y, align)	(((x) ^ (y)) > (align) - 1)
 #define	P2ROUNDUP(x, align)	((((x) - 1) | ((align) - 1)) + 1)
 #define	P2PHASE(x, align)	((x) & ((align) - 1))
diff --git a/lib/libefi/rdwr_efi.c b/lib/libefi/rdwr_efi.c
index 739219e0410f..63c91059ae5f 100644
--- a/lib/libefi/rdwr_efi.c
+++ b/lib/libefi/rdwr_efi.c
@@ -1175,8 +1175,8 @@ efi_use_whole_disk(int fd)
 	 * (for performance reasons). The alignment should match the
 	 * alignment used by the "zpool_label_disk" function.
 	 */
-	limit = P2ALIGN(efi_label->efi_last_lba - nblocks - EFI_MIN_RESV_SIZE,
-	    PARTITION_END_ALIGNMENT);
+	limit = P2ALIGN_TYPED(efi_label->efi_last_lba - nblocks -
+	    EFI_MIN_RESV_SIZE, PARTITION_END_ALIGNMENT, diskaddr_t);
 	if (data_start + data_size != limit || resv_start != limit)
 		sync_needed = B_TRUE;
 
diff --git a/lib/libspl/include/os/linux/sys/sysmacros.h b/lib/libspl/include/os/linux/sys/sysmacros.h
index 5765ee25c6cb..26e1c87a35af 100644
--- a/lib/libspl/include/os/linux/sys/sysmacros.h
+++ b/lib/libspl/include/os/linux/sys/sysmacros.h
@@ -52,7 +52,8 @@
 /*
  * Compatibility macros/typedefs needed for Solaris -> Linux port
  */
-#define	P2ALIGN(x, align)	((x) & -(align))
+// Deprecated. Use P2ALIGN_TYPED instead.
+// #define	P2ALIGN(x, align)	((x) & -(align))
 #define	P2CROSS(x, y, align)	(((x) ^ (y)) > (align) - 1)
 #define	P2ROUNDUP(x, align)	((((x) - 1) | ((align) - 1)) + 1)
 #define	P2BOUNDARY(off, len, align) \
diff --git a/lib/libzfs/os/linux/libzfs_pool_os.c b/lib/libzfs/os/linux/libzfs_pool_os.c
index 86eef3255bc2..7b18e31c8674 100644
--- a/lib/libzfs/os/linux/libzfs_pool_os.c
+++ b/lib/libzfs/os/linux/libzfs_pool_os.c
@@ -268,7 +268,8 @@ zpool_label_disk(libzfs_handle_t *hdl, zpool_handle_t *zhp, const char *name)
 	if (start_block == MAXOFFSET_T)
 		start_block = NEW_START_BLOCK;
 	slice_size -= start_block;
-	slice_size = P2ALIGN(slice_size, PARTITION_END_ALIGNMENT);
+	slice_size = P2ALIGN_TYPED(slice_size, PARTITION_END_ALIGNMENT,
+	    uint64_t);
 
 	vtoc->efi_parts[0].p_start = start_block;
 	vtoc->efi_parts[0].p_size = slice_size;
diff --git a/module/os/freebsd/zfs/vdev_geom.c b/module/os/freebsd/zfs/vdev_geom.c
index 196d67b4b595..2df13e7e187e 100644
--- a/module/os/freebsd/zfs/vdev_geom.c
+++ b/module/os/freebsd/zfs/vdev_geom.c
@@ -457,7 +457,7 @@ vdev_geom_read_config(struct g_consumer *cp, nvlist_t **configp)
 	ZFS_LOG(1, "Reading config from %s...", pp->name);
 
 	psize = pp->mediasize;
-	psize = P2ALIGN(psize, (uint64_t)sizeof (vdev_label_t));
+	psize = P2ALIGN_TYPED(psize, sizeof (vdev_label_t), uint64_t);
 
 	size = sizeof (*vdev_lists[0]) + pp->sectorsize -
 	    ((sizeof (*vdev_lists[0]) - 1) % pp->sectorsize) - 1;
diff --git a/module/os/linux/zfs/zvol_os.c b/module/os/linux/zfs/zvol_os.c
index 61c8db5d8178..41a9b1c53a29 100644
--- a/module/os/linux/zfs/zvol_os.c
+++ b/module/os/linux/zfs/zvol_os.c
@@ -384,7 +384,7 @@ zvol_discard(zv_request_t *zvr)
 	 */
 	if (!io_is_secure_erase(bio, rq)) {
 		start = P2ROUNDUP(start, zv->zv_volblocksize);
-		end = P2ALIGN(end, zv->zv_volblocksize);
+		end = P2ALIGN_TYPED(end, zv->zv_volblocksize, uint64_t);
 		size = end - start;
 	}
 
diff --git a/module/zcommon/zfs_fletcher.c b/module/zcommon/zfs_fletcher.c
index 619ddef0243a..74b8c2a475a1 100644
--- a/module/zcommon/zfs_fletcher.c
+++ b/module/zcommon/zfs_fletcher.c
@@ -471,7 +471,8 @@ fletcher_4_native(const void *buf, uint64_t size,
     const void *ctx_template, zio_cksum_t *zcp)
 {
 	(void) ctx_template;
-	const uint64_t p2size = P2ALIGN(size, FLETCHER_MIN_SIMD_SIZE);
+	const uint64_t p2size = P2ALIGN_TYPED(size, FLETCHER_MIN_SIMD_SIZE,
+	    uint64_t);
 
 	ASSERT(IS_P2ALIGNED(size, sizeof (uint32_t)));
 
@@ -519,7 +520,8 @@ fletcher_4_byteswap(const void *buf, uint64_t size,
     const void *ctx_template, zio_cksum_t *zcp)
 {
 	(void) ctx_template;
-	const uint64_t p2size = P2ALIGN(size, FLETCHER_MIN_SIMD_SIZE);
+	const uint64_t p2size = P2ALIGN_TYPED(size, FLETCHER_MIN_SIMD_SIZE,
+	    uint64_t);
 
 	ASSERT(IS_P2ALIGNED(size, sizeof (uint32_t)));
 
@@ -878,7 +880,7 @@ abd_fletcher_4_iter(void *data, size_t size, void *private)
 	fletcher_4_ctx_t *ctx = cdp->acd_ctx;
 	fletcher_4_ops_t *ops = (fletcher_4_ops_t *)cdp->acd_private;
 	boolean_t native = cdp->acd_byteorder == ZIO_CHECKSUM_NATIVE;
-	uint64_t asize = P2ALIGN(size, FLETCHER_MIN_SIMD_SIZE);
+	uint64_t asize = P2ALIGN_TYPED(size, FLETCHER_MIN_SIMD_SIZE, uint64_t);
 
 	ASSERT(IS_P2ALIGNED(size, sizeof (uint32_t)));
 
diff --git a/module/zfs/btree.c b/module/zfs/btree.c
index af2b94a850be..9c52083603f1 100644
--- a/module/zfs/btree.c
+++ b/module/zfs/btree.c
@@ -218,7 +218,7 @@ zfs_btree_create_custom(zfs_btree_t *tree,
 	    zfs_btree_find_in_buf : bt_find_in_buf;
 	tree->bt_elem_size = size;
 	tree->bt_leaf_size = lsize;
-	tree->bt_leaf_cap = P2ALIGN(esize / size, 2);
+	tree->bt_leaf_cap = P2ALIGN_TYPED(esize / size, 2, size_t);
 	tree->bt_height = -1;
 	tree->bt_bulk = NULL;
 }
diff --git a/module/zfs/dmu.c b/module/zfs/dmu.c
index d8d5cfdbd230..1d10ceebfb94 100644
--- a/module/zfs/dmu.c
+++ b/module/zfs/dmu.c
@@ -537,7 +537,8 @@ dmu_buf_hold_array_by_dnode(dnode_t *dn, uint64_t offset, uint64_t length,
 	if (dn->dn_datablkshift) {
 		int blkshift = dn->dn_datablkshift;
 		nblks = (P2ROUNDUP(offset + length, 1ULL << blkshift) -
-		    P2ALIGN(offset, 1ULL << blkshift)) >> blkshift;
+		    P2ALIGN_TYPED(offset, 1ULL << blkshift, uint64_t))
+		    >> blkshift;
 	} else {
 		if (offset + length > dn->dn_datablksz) {
 			zfs_panic_recover("zfs: accessing past end of object "
@@ -854,7 +855,7 @@ get_next_chunk(dnode_t *dn, uint64_t *start, uint64_t minimum, uint64_t *l1blks)
 		}
 
 		/* set start to the beginning of this L1 indirect */
-		*start = P2ALIGN(*start, iblkrange);
+		*start = P2ALIGN_TYPED(*start, iblkrange, uint64_t);
 	}
 	if (*start < minimum)
 		*start = minimum;
diff --git a/module/zfs/dmu_object.c b/module/zfs/dmu_object.c
index d0e39a423bb0..56986ea43446 100644
--- a/module/zfs/dmu_object.c
+++ b/module/zfs/dmu_object.c
@@ -160,7 +160,7 @@ dmu_object_alloc_impl(objset_t *os, dmu_object_type_t ot, int blocksize,
 			 * is not suitably aligned.
 			 */
 			os->os_obj_next_chunk =
-			    P2ALIGN(object, dnodes_per_chunk) +
+			    P2ALIGN_TYPED(object, dnodes_per_chunk, uint64_t) +
 			    dnodes_per_chunk;
 			(void) atomic_swap_64(cpuobj, object);
 			mutex_exit(&os->os_obj_lock);
diff --git a/module/zfs/metaslab.c b/module/zfs/metaslab.c
index dbfc00362ff8..d50225fc3f6d 100644
--- a/module/zfs/metaslab.c
+++ b/module/zfs/metaslab.c
@@ -629,8 +629,8 @@ metaslab_class_expandable_space(metaslab_class_t *mc)
 		 * metaslabs. We report the expandable space in terms
 		 * of the metaslab size since that's the unit of expansion.
 		 */
-		space += P2ALIGN(tvd->vdev_max_asize - tvd->vdev_asize,
-		    1ULL << tvd->vdev_ms_shift);
+		space += P2ALIGN_TYPED(tvd->vdev_max_asize - tvd->vdev_asize,
+		    1ULL << tvd->vdev_ms_shift, uint64_t);
 	}
 	spa_config_exit(mc->mc_spa, SCL_VDEV, FTAG);
 	return (space);
diff --git a/module/zfs/vdev.c b/module/zfs/vdev.c
index 981da4e986c4..c9ee39b468f7 100644
--- a/module/zfs/vdev.c
+++ b/module/zfs/vdev.c
@@ -347,7 +347,8 @@ vdev_get_min_asize(vdev_t *vd)
 	 * to the nearest metaslab.
 	 */
 	if (vd == vd->vdev_top)
-		return (P2ALIGN(vd->vdev_asize, 1ULL << vd->vdev_ms_shift));
+		return (P2ALIGN_TYPED(vd->vdev_asize, 1ULL << vd->vdev_ms_shift,
+		    uint64_t));
 
 	return (pvd->vdev_ops->vdev_op_min_asize(pvd));
 }
@@ -2107,8 +2108,8 @@ vdev_open(vdev_t *vd)
 		}
 	}
 
-	osize = P2ALIGN(osize, (uint64_t)sizeof (vdev_label_t));
-	max_osize = P2ALIGN(max_osize, (uint64_t)sizeof (vdev_label_t));
+	osize = P2ALIGN_TYPED(osize, sizeof (vdev_label_t), uint64_t);
+	max_osize = P2ALIGN_TYPED(max_osize, sizeof (vdev_label_t), uint64_t);
 
 	if (vd->vdev_children == 0) {
 		if (osize < SPA_MINDEVSIZE) {
@@ -4730,9 +4731,9 @@ vdev_get_stats_ex(vdev_t *vd, vdev_stat_t *vs, vdev_stat_ex_t *vsx)
 		 * can expand.
 		 */
 		if (vd->vdev_aux == NULL && tvd != NULL) {
-			vs->vs_esize = P2ALIGN(
+			vs->vs_esize = P2ALIGN_TYPED(
 			    vd->vdev_max_asize - vd->vdev_asize,
-			    1ULL << tvd->vdev_ms_shift);
+			    1ULL << tvd->vdev_ms_shift, uint64_t);
 		}
 
 		vs->vs_configured_ashift = vd->vdev_top != NULL