diff --git a/lib/galaxy/managers/users.py b/lib/galaxy/managers/users.py
index f4786c41bce1..8f4b9c428e82 100644
--- a/lib/galaxy/managers/users.py
+++ b/lib/galaxy/managers/users.py
@@ -40,6 +40,7 @@
 )
 from galaxy.managers.base import combine_lists
 from galaxy.model import (
+    Job,
     User,
     UserAddress,
     UserQuotaUsage,
@@ -161,6 +162,21 @@ def delete(self, user, flush=True):
                 "The configuration of this Galaxy instance does not allow admins to delete users."
             )
         super().delete(user, flush=flush)
+        self._stop_all_jobs_from_user(user)
+
+    def _stop_all_jobs_from_user(self, user):
+        active_jobs = self._get_all_active_jobs_from_user(user)
+        session = self.session()
+        for job in active_jobs:
+            job.mark_deleted(self.app.config.track_jobs_in_database)
+        with transaction(session):
+            session.commit()
+
+    def _get_all_active_jobs_from_user(self, user: User) -> List[Job]:
+        """Get all jobs that are not ready yet and belong to the given user."""
+        stmt = select(Job).where(and_(Job.user_id == user.id, Job.state.in_(Job.non_ready_states)))
+        jobs = self.session().scalars(stmt)
+        return jobs
 
     def undelete(self, user, flush=True):
         """Remove the deleted flag for the given user."""
diff --git a/lib/galaxy_test/api/test_users.py b/lib/galaxy_test/api/test_users.py
index a92e13769a8e..fd39e99a1473 100644
--- a/lib/galaxy_test/api/test_users.py
+++ b/lib/galaxy_test/api/test_users.py
@@ -2,13 +2,18 @@
 from galaxy_test.base.api_asserts import assert_object_id_error
 from galaxy_test.base.decorators import (
     requires_admin,
+    requires_new_history,
     requires_new_user,
 )
-from galaxy_test.base.populators import skip_without_tool
+from galaxy_test.base.populators import (
+    DatasetPopulator,
+    skip_without_tool,
+)
 
 TEST_USER_EMAIL = "user_for_users_index_test@bx.psu.edu"
 TEST_USER_EMAIL_INDEX_DELETED = "user_for_users_index_deleted_test@bx.psu.edu"
 TEST_USER_EMAIL_DELETE = "user_for_delete_test@bx.psu.edu"
+TEST_USER_EMAIL_DELETE_CANCEL_JOBS = "user_for_delete_cancel_jobs_test@bx.psu.edu"
 TEST_USER_EMAIL_PURGE = "user_for_purge_test@bx.psu.edu"
 TEST_USER_EMAIL_UNDELETE = "user_for_undelete_test@bx.psu.edu"
 TEST_USER_EMAIL_SHOW = "user_for_show_test@bx.psu.edu"
@@ -129,6 +134,45 @@ def test_undelete_user(self):
         undeleted_user = self._get(f"users/{user['id']}", admin=True).json()
         assert undeleted_user["deleted"] is False, undeleted_user
 
+    @requires_admin
+    @requires_new_user
+    @requires_new_history
+    @skip_without_tool("cat_data_and_sleep")
+    def test_delete_user_cancel_all_jobs(self):
+        dataset_populator = DatasetPopulator(self.galaxy_interactor)
+        with self._different_user(TEST_USER_EMAIL_DELETE_CANCEL_JOBS):
+            user_id = self._get_current_user_id()
+            history_id = dataset_populator.new_history()
+            hda_id = dataset_populator.new_dataset(history_id)["id"]
+
+            inputs = {
+                "input1": {"src": "hda", "id": hda_id},
+                "sleep_time": 6000,
+            }
+            run_response = dataset_populator.run_tool_raw(
+                "cat_data_and_sleep",
+                inputs,
+                history_id,
+            )
+            self._assert_status_code_is_ok(run_response)
+
+            job_id = run_response.json()["jobs"][0]["id"]
+
+            # Wait a bit for the job to be ready
+            expected_job_states = ["new", "queued", "running"]
+            dataset_populator.wait_for_job(job_id, ok_states=expected_job_states)
+
+            # Get the job state
+            job_response = self._get(f"jobs/{job_id}").json()
+            assert job_response["state"] in expected_job_states, job_response
+
+            # Delete user will cancel all jobs
+            self._delete(f"users/{user_id}", admin=True)
+
+            # Get the job state again (this time as admin), it should be deleting
+            job_response = self._get(f"jobs/{job_id}", admin=True).json()
+            assert job_response["state"] == "deleting", job_response
+
     @requires_new_user
     def test_information(self):
         user = self._setup_user(TEST_USER_EMAIL)