diff --git a/lib/galaxy/webapps/base/api.py b/lib/galaxy/webapps/base/api.py
index ad0ac2d8a781..38eb01d382ce 100644
--- a/lib/galaxy/webapps/base/api.py
+++ b/lib/galaxy/webapps/base/api.py
@@ -239,19 +239,15 @@ def add_request_id_middleware(app: FastAPI):
 
 def include_all_package_routers(app: FastAPI, package_name: str):
     responses: typing.Dict[typing.Union[int, str], typing.Dict[str, typing.Any]] = {
-        422: {
-            "description": "Validation error",
+        "4XX": {
+            "description": "Client Error",
             "model": MessageExceptionModel,
         },
-    }
-    for code, error in error_codes_by_int_code.items():
-        code_int = int(str(code)[:3])
-        if code_int in [0, 204] or code_int in responses:
-            continue
-        responses[code_int] = {
-            "description": str(error),
+        "5XX": {
+            "description": "Server Error",
             "model": MessageExceptionModel,
-        }
+        },
+    }
     for _, module in walk_controller_modules(package_name):
         router = getattr(module, "router", None)
         if router: