diff --git a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/rule_creation/esql_rule_ess.cy.ts b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/rule_creation/esql_rule_ess.cy.ts
index 0e10557bcaf0e..f3a898e430a4e 100644
--- a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/rule_creation/esql_rule_ess.cy.ts
+++ b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/rule_creation/esql_rule_ess.cy.ts
@@ -38,7 +38,8 @@ describe('Detection ES|QL rules, creation', { tags: ['@ess'] }, () => {
   const rule = getEsqlRule();
   const expectedNumberOfRules = 1;
 
-  describe('creation', () => {
+  // FLAKY: https://github.com/elastic/kibana/issues/172251
+  describe.skip('creation', () => {
     beforeEach(() => {
       deleteAlertsAndRules();
       login();
diff --git a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/rule_edit/esql_rule.cy.ts b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/rule_edit/esql_rule.cy.ts
index 20d48b211995e..445b33a682f9c 100644
--- a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/rule_edit/esql_rule.cy.ts
+++ b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/rule_edit/esql_rule.cy.ts
@@ -34,7 +34,10 @@ const rule = getEsqlRule();
 
 const expectedValidEsqlQuery = 'from auditbeat* | stats count(event.category) by event.category';
 
-describe('Detection ES|QL rules, edit', { tags: ['@ess'] }, () => {
+// FLAKY: https://github.com/elastic/kibana/issues/172253
+// FLAKY: https://github.com/elastic/kibana/issues/172254
+// FLAKY: https://github.com/elastic/kibana/issues/172255
+describe.skip('Detection ES|QL rules, edit', { tags: ['@ess'] }, () => {
   beforeEach(() => {
     login();
     deleteAlertsAndRules();