diff --git a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a-CUDA-11.3.1.eb b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a-CUDA-11.3.1.eb
index 9690edeb0ea..fdd93ce220f 100644
--- a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a-CUDA-11.3.1.eb
+++ b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a-CUDA-11.3.1.eb
@@ -29,6 +29,7 @@ dependencies = [
 ]
 
 configopts = ' -DCMAKE_SKIP_RPATH=OFF -DWITH_TESTS=ON -DWITH_CUDA=ON'
+configopts += ' -DPython3_EXECUTABLE=$EBROOTPYTHON/bin/python '  # Make sure the right python is used
 
 runtest = 'check_unit_tests && make check_python'
 
diff --git a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a.eb b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a.eb
index b18d54ed895..48b505bfc9e 100644
--- a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a.eb
+++ b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a.eb
@@ -27,6 +27,7 @@ dependencies = [
 ]
 
 configopts = ' -DCMAKE_SKIP_RPATH=OFF -DWITH_TESTS=ON -DWITH_CUDA=OFF'
+configopts += ' -DPython3_EXECUTABLE=$EBROOTPYTHON/bin/python '  # Make sure the right python is used
 
 runtest = 'check_unit_tests && make check_python'
 
diff --git a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a-CUDA-11.8.0.eb b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a-CUDA-11.8.0.eb
index 907da191566..e89797a4b16 100644
--- a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a-CUDA-11.8.0.eb
+++ b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a-CUDA-11.8.0.eb
@@ -29,6 +29,7 @@ dependencies = [
 ]
 
 configopts = ' -DCMAKE_SKIP_RPATH=OFF -DWITH_TESTS=ON -DWITH_CUDA=ON'
+configopts += ' -DPython3_EXECUTABLE=$EBROOTPYTHON/bin/python '  # Make sure the right python is used
 
 runtest = 'check_unit_tests && make check_python'
 
diff --git a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a.eb b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a.eb
index 032b259661d..6ff43deee93 100644
--- a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a.eb
+++ b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a.eb
@@ -27,6 +27,7 @@ dependencies = [
 ]
 
 configopts = ' -DCMAKE_SKIP_RPATH=OFF -DWITH_TESTS=ON -DWITH_CUDA=OFF'
+configopts += ' -DPython3_EXECUTABLE=$EBROOTPYTHON/bin/python '  # Make sure the right python is used
 
 runtest = 'check_unit_tests && make check_python'