diff --git a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a-CUDA-11.3.1.eb b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a-CUDA-11.3.1.eb
index fdd93ce220f..4808bb96632 100644
--- a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a-CUDA-11.3.1.eb
+++ b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a-CUDA-11.3.1.eb
@@ -29,7 +29,8 @@ dependencies = [
 ]
 
 configopts = ' -DCMAKE_SKIP_RPATH=OFF -DWITH_TESTS=ON -DWITH_CUDA=ON'
-configopts += ' -DPython3_EXECUTABLE=$EBROOTPYTHON/bin/python '  # Make sure the right python is used
+# make sure the right Python is used (note: -DPython3_EXECUTABLE or -DPython_EXECUTABLE does not work!)
+configopts += ' -DPYTHON_EXECUTABLE=$EBROOTPYTHON/bin/python '
 
 runtest = 'check_unit_tests && make check_python'
 
diff --git a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a.eb b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a.eb
index 48b505bfc9e..edaea20c78c 100644
--- a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a.eb
+++ b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2021a.eb
@@ -27,7 +27,8 @@ dependencies = [
 ]
 
 configopts = ' -DCMAKE_SKIP_RPATH=OFF -DWITH_TESTS=ON -DWITH_CUDA=OFF'
-configopts += ' -DPython3_EXECUTABLE=$EBROOTPYTHON/bin/python '  # Make sure the right python is used
+# make sure the right Python is used (note: -DPython3_EXECUTABLE or -DPython_EXECUTABLE does not work!)
+configopts += ' -DPYTHON_EXECUTABLE=$EBROOTPYTHON/bin/python '
 
 runtest = 'check_unit_tests && make check_python'
 
diff --git a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a-CUDA-11.8.0.eb b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a-CUDA-11.8.0.eb
index e89797a4b16..c524dee3c8c 100644
--- a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a-CUDA-11.8.0.eb
+++ b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a-CUDA-11.8.0.eb
@@ -29,7 +29,8 @@ dependencies = [
 ]
 
 configopts = ' -DCMAKE_SKIP_RPATH=OFF -DWITH_TESTS=ON -DWITH_CUDA=ON'
-configopts += ' -DPython3_EXECUTABLE=$EBROOTPYTHON/bin/python '  # Make sure the right python is used
+# make sure the right Python is used (note: -DPython3_EXECUTABLE or -DPython_EXECUTABLE does not work!)
+configopts += ' -DPYTHON_EXECUTABLE=$EBROOTPYTHON/bin/python '
 
 runtest = 'check_unit_tests && make check_python'
 
diff --git a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a.eb b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a.eb
index 6ff43deee93..e5bd5a63f74 100644
--- a/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a.eb
+++ b/easybuild/easyconfigs/e/ESPResSo/ESPResSo-4.2.1-foss-2022a.eb
@@ -27,7 +27,8 @@ dependencies = [
 ]
 
 configopts = ' -DCMAKE_SKIP_RPATH=OFF -DWITH_TESTS=ON -DWITH_CUDA=OFF'
-configopts += ' -DPython3_EXECUTABLE=$EBROOTPYTHON/bin/python '  # Make sure the right python is used
+# make sure the right Python is used (note: -DPython3_EXECUTABLE or -DPython_EXECUTABLE does not work!)
+configopts += ' -DPYTHON_EXECUTABLE=$EBROOTPYTHON/bin/python '
 
 runtest = 'check_unit_tests && make check_python'