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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="utf-8">
<meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
<meta name="description" content="">
<meta name="author" content="">
<title>CMT Genetic Research</title>
<!-- Bootstrap core CSS -->
<link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/css/bootstrap.min.css">
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<script src="contact.js"></script>
<!-- SurveyJS -->
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<link href="https://surveyjs.azureedge.net/1.1.1/survey.css" type="text/css" rel="stylesheet" />
<!-- Accordian toggle buttons -->
<script>
$(document).ready(function() {
// Add minus icon for collapse element which is open by default
$(".collapse.show").each(function() {
$(this).prev(".card-header").find(".fa").addClass("fa-minus").removeClass("fa-plus");
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$(".collapse").on('show.bs.collapse', function() {
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}).on('hide.bs.collapse', function() {
$(this).prev(".card-header").find(".fa").removeClass("fa-minus").addClass("fa-plus");
});
});
</script>
<style>
.accordian-more-info {
margin: 20px;
}
.accordion .fa {
margin-right: 0.5rem;
}
</style>
</head>
<body id="page-top">
<!-- Navigation -->
<nav class="navbar navbar-expand-lg navbar-dark bg-dark fixed-top" id="mainNav">
<div class="container">
<a class="navbar-brand js-scroll-trigger" href="#page-top">Find My CMT Gene</a>
<button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#navbarResponsive" aria-controls="navbarResponsive" aria-expanded="false" aria-label="Toggle navigation">
<span class="navbar-toggler-icon"></span>
</button>
<div class="collapse navbar-collapse" id="navbarResponsive">
<ul class="navbar-nav ml-auto">
<li class="nav-item">
<a class="nav-link js-scroll-trigger" href="#about">About</a>
</li>
<li class="nav-item">
<a class="nav-link js-scroll-trigger" href="#data">Data</a>
</li>
<li class="nav-item">
<a class="nav-link js-scroll-trigger" href="#protocol">Protocol</a>
</li>
<li class="nav-item">
<a class="nav-link js-scroll-trigger" href="#learn_more">Learn More</a>
</li>
<li class="nav-item">
<a class="nav-link js-scroll-trigger" href="#join">Join</a>
</li>
<li class="nav-item">
<a class="nav-link js-scroll-trigger" href="#contact">Contact</a>
</li>
</ul>
</div>
</div>
</nav>
<header class="jumbotron jumbotron-fluid" id="index_header">
<div class="container text-center" id="index_header_text">
<h1 class="display-4">Welcome to the CMT Genome Hub</h1>
<p class="lead">To understand the genetic basis of ALS and to ultimately find a cure for this devastating, fatal neuromuscular disease, Project MinE aims to analyse the DNA of at least 15,000 ALS patients/p>
</div>
</header>
<!-- About -->
<section id="about">
<div class="container-fluid">
<div class="row">
<div class="col-lg-8 mx-auto">
<h2>You are diagnosed with neuropathy and genetic tests have come back without results?</h2>
<p class="lead text-justify">The CMT Genome Hub has a simple mission: to improve the diagostic rate of CMT families. This will enable more therapy studies. Using whole genome analysis we are discovering new neuropathy genes and . To do this, we’re asking patients to contribute their biosamples. We will use these samples to:</p>
<ul>
<li>Discover novel disease gene associations</li>
<li>Reveal DNA mutations in known disease genes</li>
<li>Correlate DNA mutations with clinical outcomes</li>
<li>Guide patient specific therapies</li>
</ul>
</div>
</div>
</div>
</section>
<!-- Data -->
<section id="data" class="bg-light">
<div class="container-fluid">
<div class="row">
<div class="col-lg-8 mx-auto">
<h2>Data Snapshots</h2>
<p class="lead text-justify">Interested in quickly viewing the diversity of the CMT Genetics Research Program participant data? Our Data Snapshots are the fastest way to view the diversity of the CMT Genetics Research Program participant data set. Updated regularly, these
snapshots provide visualizations of participant demographics, geographical distribution, and more.</p>
<div class="container">
<div class="row">
<div class="col">
<figure class="figure">
<img src="https://www.researchallofus.org/wp-content/themes/research-hub-wordpress-theme/media/2019/02/participants.png" alt="" width="125" height="125" class="figure-img img-fluid rounded">
<figcaption class="figure-caption">
<h3 class="text-center">10,000+</h3>
<p class="text-center font-weight-bolder">Participants</p>
</figcaption>
</figure>
</div>
<div class="col">
<figure class="figure">
<img src="https://www.researchallofus.org/wp-content/themes/research-hub-wordpress-theme/media/2019/02/electronic-health-records.png" alt="" width="125" height="125" class="figure-img img-fluid rounded">
<figcaption class="figure-caption">
<h3 class="text-center">6,000+</h3>
<p class="text-center font-weight-bolder">Whole Exomes</p>
</figcaption>
</figure>
</div>
<div class="col">
<figure class="figure">
<img src="https://www.researchallofus.org/wp-content/themes/research-hub-wordpress-theme/media/2019/02/biosamples_data.png" alt="" width="125" height="125" class="figure-img img-fluid rounded">
<figcaption class="figure-caption">
<h3 class="text-center">7,000+</h3>
<p class="text-center font-weight-bolder">Biosamples Received</p>
</figcaption>
</figure>
</div>
</div>
</div>
</div>
</div>
</div>
</section>
<!-- Protocol -->
<section id="protocol">
<div class="container-fluid">
<div class="row">
<div class="col-lg-8 mx-auto">
<div class="container-fluid">
<div class="row" style="height: 100px;">
<div class="col">
</div>
<div class="col">
<h2 class="text-center">How it works</h2>
</div>
<div class="col">
</div>
</div>
<div class="container-fluid">
<div class="row">
<div class="col">
<h5>Participants submit biosample</h5>
<p class="">Participants send a saliva or blood sample for DNA sequencing.</p>
</div>
<div class="col text-center">
<img src="https://www.joinallofus.org/sites/default/files/2018-04/participants-share-data-icon_0.png" class="img-fluid" alt="">
</div>
<div class="col">
</div>
</div>
</div>
<div class="container-fluid" style="height: 50px;">
<div class="row">
<div class="col"></div>
<div class="col">
<div class="vl" style="height: 50px;"></div>
</div>
<div class="col"></div>
</div>
</div>
<div class="container-fluid">
<div class="row">
<div class="col">
</div>
<div class="col text-center">
<img src="https://www.joinallofus.org/sites/default/files/2018-04/data-is-protected_0.png" class="img-fluid" alt="">
</div>
<div class="col">
<h5>Data is protected</h5>
<p class="">Personal information, like your name, address, and other things that easily identify participants will be removed from all data. Samples are stored in a secure biobank.</p>
</div>
</div>
</div>
<div class="container-fluid" style="height: 50px;">
<div class="row">
<div class="col"></div>
<div class="col">
<div class="vl" style="height: 50px;"></div>
</div>
<div class="col"></div>
</div>
</div>
<div class="container-fluid">
<div class="row">
<div class="col">
<h5>Researchers study DNA</h5>
<p class="">DNA samples are sequenced and analyzed to make discoveries about mutated genes.</p>
</div>
<div class="col text-center">
<img src="https://www.joinallofus.org/sites/default/files/2018-04/researchers-study-data_0.png" class="img-fluid" alt="">
</div>
<div class="col">
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</section>
<!-- Learn More -->
<section id="learn_more" class="bg-light">
<div class="container-fluid">
<div class="row">
<div class="col-lg-8 mx-auto">
<h2>Want more information?</h2>
<p class="lead">Learn more about CMT, genetics, and our study below</p>
<!-- Accordian -->
<div class="accordian-more-info">
<div class="accordion" id="accordionExample">
<div class="card">
<div class="card-header" id="headingOne">
<h2 class="mb-0">
<button type="button" class="btn btn-link" data-toggle="collapse" data-target="#collapseOne"><i class="fa fa-plus"></i> What is CMT?</button>
</h2>
</div>
<div id="collapseOne" class="collapse" aria-labelledby="headingOne" data-parent="#accordionExample">
<div class="card-body">
<p>CMT stands for Charcot-Marie-Tooth disease and is a spectrum of genetic disorders that affects the peripheral nerves (unlike muscular dystrophies, which affect the muscles themselves). CMT occurs in both genders and all ethnic groups,
affecting more than 3 million people worldworld. Learn more <a href="https://www.cmtausa.org/understanding-cmt/what-is-cmt/" target="_blank">here</a> and <a href="https://www.mda.org/disease/charcot-marie-tooth" target="_blank">here.</a></p>
</div>
</div>
</div>
<div class="card">
<div class="card-header" id="headingTwo">
<h2 class="mb-0">
<button type="button" class="btn btn-link collapsed" data-toggle="collapse" data-target="#collapseTwo"><i class="fa fa-plus"></i> What causes CMT?</button>
</h2>
</div>
<div id="collapseTwo" class="collapse" aria-labelledby="headingTwo" data-parent="#accordionExample">
<div class="card-body">
<p>CMT is not caused by anything a person does and is not contangious. CMT is hereditary, meaning it can run in a family from one generation to the next. Learn more about CMT inheritance patterns <a href="https://www.cmtausa.org/understanding-cmt/types-of-cmt/genetics-and-inheritance/"
target="_blank">here</a> and <a href="https://www.mda.org/disease/charcot-marie-tooth/causes-inheritance" target="_blank">here.</a></p>
</div>
</div>
</div>
<div class="card">
<div class="card-header" id="headingThree">
<h2 class="mb-0">
<button type="button" class="btn btn-link collapsed" data-toggle="collapse" data-target="#collapseThree"><i class="fa fa-plus"></i> What is genetic testing?</button>
</h2>
</div>
<div id="collapseThree" class="collapse" aria-labelledby="headingThree" data-parent="#accordionExample">
<div class="card-body">
<p>After a patient is clinically diagnosed with CMT, a neurologist may arrange for genetic testing. Genetic testing can provide a patient with more specific diagnosis information, including the mutated gene and subtype. Genetic testing
can be useful for many reasons:
<ul>
<li>Confirm CMT diagnosis since early symptoms can mimic other disorders</li>
<li>Enable family members to determine if they are affected</li>
<li>Help make decisions regarding family planning</li>
<li>Learn about potential subtype-specific therapies</li>
</ul>
Learn more about genetic counseling <a href="https://www.nsgc.org/page/patients" target="_blank">here.</a>
</p>
</div>
</div>
</div>
<div class="card">
<div class="card-header" id="headingFour">
<h2 class="mb-0">
<button type="button" class="btn btn-link collapsed" data-toggle="collapse" data-target="#collapseFour"><i class="fa fa-plus"></i> What is DNA sequencing?</button>
</h2>
</div>
<div id="collapseFour" class="collapse" aria-labelledby="headingFour" data-parent="#accordionExample">
<div class="card-body">
<p>DNA sequencing is...</a>
</p>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</section>
<!-- Join -->
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<h2>Join our study</h2>
<p class="lead">If you are interested in joining our study, please answer the questions below to verify your eligibility.</p>
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<p class="lead"><a href="https://redcap.miami.edu/surveys/?s=MCWPYKLTXN">Click here to consent to join.</a></p>
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<!-- Email contact form -->
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<h2>Contact us</h2>
<form id="contact-form" method="post" action="contact.php" role="form">
<div class="messages"></div>
<div class="controls">
<!-- Name form -->
<div class="row">
<div class="col-md-6">
<div class="form-group">
<label for="form_name">First name *</label>
<input id="form_name" type="text" name="name" class="form-control" placeholder="John" required="required" data-error="Firstname is required.">
<div class="help-block with-errors"></div>
</div>
</div>
<div class="col-md-6">
<div class="form-group">
<label for="form_lastname">Last name *</label>
<input id="form_lastname" type="text" name="surname" class="form-control" placeholder="Doe" required="required" data-error="Lastname is required.">
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<label for="form_email">Email *</label>
<input id="form_email" type="email" name="email" class="form-control" placeholder="[email protected]" required="required" data-error="Valid email is required.">
<div class="help-block with-errors"></div>
</div>
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<div class="col-md-6">
<div class="form-group">
<label for="form_phone">Phone number</label>
<input id="form_phone" type="tel" name="tel" class="form-control" placeholder="305-555-5555" data-error="Valid phone number is required.">
<div class="help-block with-errors"></div>
</div>
</div>
</div>
<!-- Diagnosis form -->
<div class="row">
<div class="col-md-6">
<div class="form-group">
<label for="form_diagnosis">Clinical diagnosis *</label>
<select id="form_diagnosis" name="clinical_diagnosis" class="form-control" required="required" data-error="Please specify your clinical diagnosis.">
<option value=""></option>
<option value="Charcot-Marie-Tooth disease">Charcot-Marie-Tooth disease</option>
<option value="Hereditary motor and sensory neuropathy">Hereditary motor and sensory neuropathy</option>
<option value="Hereditary motor neuropathy">Hereditary motor neuropathy</option>
<option value="Hereditary motor and autonomic neuropathy">Hereditary motor and autonomic neuropathy</option>
<option value="Spinal muscular atrophy">Spinal muscular atrophy</option>
<option value="Other">Other</option>
<option value="Not affected">Not affected</option>
</select>
<div class="help-block with-errors"></div>
</div>
</div>
<div class="col-md-6">
<div class="form-group">
<label for="form_genetic">Genetic diagnosis </label>
<input id="form_genetic" type="text" name="genetic" class="form-control" placeholder="PMP22 duplication" rows="4" data-error="Please enter your genetic diagnosis."></input>
<div class="help-block with-errors"></div>
</div>
</div>
</div>
<!-- Message form -->
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<div class="form-group">
<label for="form_message">Message</label>
<textarea id="form_message" name="message" class="form-control" placeholder="Please send us your comments, questions, or concerns." rows="4" data-error="Please, leave us a message."></textarea>
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<input type="submit" class="btn btn-success btn-send" value="Send message">
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<p class="text-muted">
<strong>*</strong> These fields are required.</p>
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