regex exclusion & exclusion based on prior string

[O815163]

I found that on Windows Server 2019 almost every user folder has a few false-positive detection.

C:\Users__\Local Settings\Packages\Microsoft.Windows.Cortana_cw5n1h2txyewy\

Is there any possibility to exclude detections based on a regular expression, or can I only exclude "C:\Users"?

Also would it be possible to exclude based on what comes before the PAN? - e.g. if there is "messageID:" in the same line prior to the falsely detected PAN