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-Jekyll2023-12-23T11:55:19+00:00/preview/pr-25/feed.xmlDalmolin Systems Biology GroupAn engaging 1-3 sentence description of your lab.
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+Jekyll2023-12-23T12:08:30+00:00/preview/pr-25/feed.xmlDalmolin Systems Biology GroupAn engaging 1-3 sentence description of your lab.
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Evolution of biological systems
An algorithm to infer the evolutionary root of orthologous groups
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The development of sequencing technologies in the past two decades allowed the study of the phylogenic relationship of several model organisms. An interesting question relies on the mechanisms behind how new genes arise and how they interact and evolve together to build the intricate network of genes observed on the organism’s biochemical pathways. Gene duplication is highlighted as a crucial event in genome evolution, offering a prime source for genetic material and allowing evolutionary forces to generate novelty. In the Dalmolin et al, 2011 paper, the importance of duplication events in the evolutionary history of orthologous groups is assessed by the ratio of components to the number of organisms with items from the group. The study extends to analyze Eukaryotic Clusters of Orthologous Groups (KOG) in STRING, evaluating the evolutionary plasticity and conservation of groups based on component distribution across eukaryotic genomes, proposing an equation for plasticity, and identifying correlations between evolutionary distance and plasticity. The algorithm used in this paper to infer the evolutionary root of orthologous groups, based on a phylogenetic tree from eukaryotes, is implemented as an R/Bioconductor package called geneplast.
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The development of sequencing technologies in the past two decades allowed the study of the phylogenetic relationship of several model organisms. An interesting question relies on the mechanisms behind how new genes arise and how they interact and evolve together to build the intricate network of genes observed in the organism’s biochemical pathways. Gene duplication is highlighted as a crucial event in genome evolution, offering a prime source for genetic material and allowing evolutionary forces to generate novelty. In the Dalmolin et al, 2011 paper, the importance of duplication events in the evolutionary history of orthologous groups is assessed by the ratio of components to the number of organisms with items from the group. The study extends to analyze Eukaryotic Clusters of Orthologous Groups (KOG) in STRING, evaluating the evolutionary plasticity and conservation of groups based on component distribution across eukaryotic genomes, proposing an equation for plasticity, and identifying correlations between evolutionary distance and plasticity. The algorithm used in this paper to infer the evolutionary root of orthologous groups, based on a phylogenetic tree from eukaryotes, is implemented as an R/Bioconductor package called geneplast.