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In Cytoscape 3.7.x, the largest visible culprit is loading the cytoscape-jetty feature, which takes the bulk of the load time. This was a necessary evil because the versions of Karaf in Cytoscape 3.7.x didn't contain the necessary jetty updates CyREST needed.
In Cytoscape 3.8.0, we can switch to Karaf's newly updated jetty; this results in a faster (16 second) load time. This was implemented in af40461
We may be able to further speed things up by updating the jersey-min bundles, a task which we should be attending to anyway.
On Ubuntu systems, the CyREST bundle reports 4 seconds of startup time in the framework log.
On Windows, this stretches out to 40 seconds.
Originally reported by the StringApp group.
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