diff --git a/CMakeLists.txt b/CMakeLists.txt
index eb55629d..41cf0041 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -3,7 +3,7 @@ PROJECT(DIAGPathology)
 
 SET(CURRENT_MAJOR_VERSION 1)
 SET(CURRENT_MINOR_VERSION 7)
-SET(CURRENT_PATCH_VERSION 1)
+SET(CURRENT_PATCH_VERSION 3)
 set(ASAP_VERSION ${CURRENT_MAJOR_VERSION}.${CURRENT_MINOR_VERSION}.${CURRENT_PATCH_VERSION})
 
 include (GenerateExportHeader)
diff --git a/core/Patch.h b/core/Patch.h
index ef59bbfa..ff5815da 100644
--- a/core/Patch.h
+++ b/core/Patch.h
@@ -14,6 +14,8 @@ class Patch : public ImageSource {
   bool _ownData;
   std::vector<unsigned long long> _dimensions;
   std::vector<unsigned long long> _strides;
+  std::vector<double> _wsiMinValues;
+  std::vector<double> _wsiMaxValues;
   void calculateStrides();
 
   void swap(Patch<T>& first, Patch<T>& second);
@@ -24,7 +26,7 @@ public :
   ~Patch();
   Patch(const Patch& rhs);
   Patch& operator=(const Patch rhs);
-  Patch(const std::vector<unsigned long long>& dimensions, const pathology::ColorType& ctype = pathology::Monochrome, T* data = NULL, bool ownData = true);
+  Patch(const std::vector<unsigned long long>& dimensions, const pathology::ColorType& ctype = pathology::Monochrome, T* data = NULL, bool ownData = true, std::vector<double> wsiMinValues = std::vector<double>(), std::vector<double> wsiMaxValues = std::vector<double>());
 
   // Arithmetic operators
   Patch<T> operator*(const T& val);
@@ -41,8 +43,13 @@ public :
 
   std::vector<unsigned long long> getStrides();
 
+  double getWSIMinValue(int channel = -1) const;
+  double getWSIMaxValue(int channel = -1) const;
+
   double getMinValue(int channel = -1);
   double getMaxValue(int channel = -1);
+  double getMinValue(int channel = -1) const;
+  double getMaxValue(int channel = -1) const;
 
   T getValue(const std::vector<unsigned long long>& index) const;
   void setValue(const std::vector<unsigned long long>& index, const T& value);
diff --git a/core/Patch.hpp b/core/Patch.hpp
index 47afbc1a..0119dd21 100644
--- a/core/Patch.hpp
+++ b/core/Patch.hpp
@@ -59,6 +59,32 @@ Patch<T>::~Patch()
   }
 }
 
+template<typename T>
+double Patch<T>::getWSIMinValue(int channel) const {
+  if (channel < 0) {
+    return *std::max_element(_wsiMinValues.begin(), _wsiMinValues.end());
+  }
+  else if (channel < _wsiMinValues.size()) {
+    return _wsiMinValues[channel];
+  }
+  else{
+    return std::numeric_limits<double>::max();
+  }
+}
+
+template<typename T>
+double Patch<T>::getWSIMaxValue(int channel) const  {
+  if (channel < 0) {
+    return *std::max_element(_wsiMaxValues.begin(), _wsiMaxValues.end());
+  }
+  else if (channel < _wsiMaxValues.size()) {
+    return _wsiMaxValues[channel];
+  }
+  else{
+    return std::numeric_limits<double>::min();
+  }
+}
+
 template<typename T>
 double Patch<T>::getMinValue(int channel) {
   double min = std::numeric_limits<double>::max();
@@ -85,6 +111,32 @@ double Patch<T>::getMaxValue(int channel) {
   return max;
 }
 
+template<typename T>
+double Patch<T>::getMinValue(int channel) const  {
+  double min = std::numeric_limits<double>::max();
+  if (_buffer) {
+    for (int i = 0; i < _bufferSize; ++i) {
+      if (_buffer[i] < min) {
+        min = _buffer[i];
+      }
+    }
+  }
+  return min;
+}
+
+template<typename T>
+double Patch<T>::getMaxValue(int channel) const {
+  double max = std::numeric_limits<double>::min();
+  if (_buffer) {
+    for (int i = 0; i < _bufferSize; ++i) {
+      if (_buffer[i] > max) {
+        max = _buffer[i];
+      }
+    }
+  }
+  return max;
+}
+
 
 template<typename T>
 const int Patch<T>::getSamplesPerPixel() const {
@@ -102,7 +154,7 @@ const unsigned long long Patch<T>::getBufferSize() const {
 }
 
 template<typename T>
-Patch<T>::Patch(const std::vector<unsigned long long>& dimensions, const pathology::ColorType& colorType, T* data, bool ownData) :
+Patch<T>::Patch(const std::vector<unsigned long long>& dimensions, const pathology::ColorType& colorType, T* data, bool ownData, std::vector<double> wsiMinValues, std::vector<double> wsiMaxValues) :
    ImageSource(),
   _dimensions(dimensions),
   _buffer(data),
@@ -128,6 +180,8 @@ Patch<T>::Patch(const std::vector<unsigned long long>& dimensions, const patholo
       _colorType = pathology::Indexed;
     }
   }
+  this->_wsiMaxValues = wsiMaxValues;
+  this->_wsiMinValues = wsiMinValues;
   calculateStrides();
   _isValid = true;
 }
@@ -139,7 +193,9 @@ Patch<T>::Patch(const Patch<T>& rhs) :
   _dimensions(rhs._dimensions),
   _ownData(true),
   _strides(rhs._strides),
-  _buffer(NULL)
+  _buffer(NULL),
+  _wsiMinValues(rhs._wsiMinValues),
+  _wsiMaxValues(rhs._wsiMaxValues)
 {
   _buffer = new T[_bufferSize];
   std::copy(rhs._buffer, rhs._buffer + rhs._bufferSize, _buffer);
@@ -153,6 +209,8 @@ void Patch<T>::swap(Patch<T>& first, Patch<T>& second) {
   std::swap(first._buffer, second._buffer);
   std::swap(first._bufferSize, second._bufferSize);
   std::swap(first._ownData, second._ownData);
+  std::swap(first._wsiMinValues, second._wsiMinValues);
+  std::swap(first._wsiMaxValues, second._wsiMaxValues);
   std::swap(first._strides, second._strides);
 }
 
diff --git a/io/multiresolutionimageinterface/CMakeLists.txt b/io/multiresolutionimageinterface/CMakeLists.txt
index 21943da9..bca17685 100644
--- a/io/multiresolutionimageinterface/CMakeLists.txt
+++ b/io/multiresolutionimageinterface/CMakeLists.txt
@@ -81,6 +81,7 @@ IF(BUILD_MULTIRESOLUTIONIMAGEINTERFACE_VSI_SUPPORT)
 FIND_PACKAGE(DCMTKJPEG REQUIRED)
 ADD_LIBRARY(multiresolutionimageinterface SHARED ${MULTIRESOLUTIONIMAGEINTERFACE_SRCS} ${MULTIRESOLUTIONIMAGEINTERFACE_HS} ${VSI_SOURCE_HS} ${VSI_SOURCE_SRCS})
 TARGET_LINK_LIBRARIES(multiresolutionimageinterface PRIVATE ${DCMTKJPEG_LIBRARY} libtiff core libjasper libjpeg zlib pugixml Boost::disable_autolinking Boost::thread)
+TARGET_COMPILE_DEFINITIONS(multiresolutionimageinterface PRIVATE HAS_MULTIRESOLUTIONIMAGEINTERFACE_VSI_SUPPORT)
 ELSE(BUILD_MULTIRESOLUTIONIMAGEINTERFACE_VSI_SUPPORT)
 ADD_LIBRARY(multiresolutionimageinterface SHARED ${MULTIRESOLUTIONIMAGEINTERFACE_SRCS} ${MULTIRESOLUTIONIMAGEINTERFACE_HS})
 TARGET_LINK_LIBRARIES(multiresolutionimageinterface PRIVATE libtiff core libjasper libjpeg zlib pugixml Boost::disable_autolinking Boost::thread)
diff --git a/io/multiresolutionimageinterface/MultiResolutionImage.h b/io/multiresolutionimageinterface/MultiResolutionImage.h
index ed51b2ed..4fe4531d 100644
--- a/io/multiresolutionimageinterface/MultiResolutionImage.h
+++ b/io/multiresolutionimageinterface/MultiResolutionImage.h
@@ -75,7 +75,12 @@ public :
     for (unsigned int i = 0; i < _spacing.size(); ++i) {
       patchSpacing[i] = _spacing[i] * levelDownsample;
     }
-    Patch<T> patch = Patch<T>(dims, this->getColorType(), data, true);
+    std::vector<double> minValues, maxValues;
+    for (unsigned int i = 0; i < this->getSamplesPerPixel(); ++i) {
+      minValues.push_back(this->getMinValue(i));
+      maxValues.push_back(this->getMaxValue(i));
+    }
+    Patch<T> patch = Patch<T>(dims, this->getColorType(), data, true, minValues, maxValues);
     patch.setSpacing(patchSpacing);
     return patch;
   }
diff --git a/io/multiresolutionimageinterface/MultiResolutionImageFactory.cpp b/io/multiresolutionimageinterface/MultiResolutionImageFactory.cpp
index 94c75943..93c79643 100644
--- a/io/multiresolutionimageinterface/MultiResolutionImageFactory.cpp
+++ b/io/multiresolutionimageinterface/MultiResolutionImageFactory.cpp
@@ -1,9 +1,12 @@
 #include "MultiResolutionImageFactory.h"
 #include "MultiResolutionImage.h"
-#include "VSIImage.h"
 #include "core/filetools.h"
 #include "core/stringconversion.h"
 
+#ifdef HAS_MULTIRESOLUTIONIMAGEINTERFACE_VSI_SUPPORT
+#include "VSIImage.h"
+#endif
+
 #ifdef _WIN32
 #include <windows.h>
 #else
@@ -30,7 +33,12 @@ MultiResolutionImage* MultiResolutionImageFactory::openImage(const std::string&
     if (std::find(factoryExtensions.begin(), factoryExtensions.end(), extension) != factoryExtensions.end()) {
       MultiResolutionImage* img = it->second->readImage(fileName);
       if (img) {
+
+#ifdef HAS_MULTIRESOLUTIONIMAGEINTERFACE_VSI_SUPPORT
         if ((img->getNumberOfLevels() > 1 || dynamic_cast<VSIImage*>(img) != NULL) || (img->getNumberOfLevels() == 1 && img->getLevelDimensions(0)[0] < 4096)) {
+#else
+        if ((img->getNumberOfLevels() > 1) || (img->getNumberOfLevels() == 1 && img->getLevelDimensions(0)[0] < 4096)) {
+#endif
           return img;
         }
         else {
diff --git a/io/multiresolutionimageinterface/TIFFImage.cpp b/io/multiresolutionimageinterface/TIFFImage.cpp
index ed28e81f..bb526ed5 100644
--- a/io/multiresolutionimageinterface/TIFFImage.cpp
+++ b/io/multiresolutionimageinterface/TIFFImage.cpp
@@ -272,8 +272,8 @@ template <typename T> T* TIFFImage::FillRequestedRegionFromTIFF(const long long&
   std::fill(temp,temp+width*height*nrSamples,static_cast<T>(0));
   unsigned int tileW=_tileSizesPerLevel[level][0], tileH=_tileSizesPerLevel[level][1], levelH=_levelDimensions[level][1], levelW=_levelDimensions[level][0];
 
-  long long levelStartX = startX / getLevelDownsample(level);
-  long long levelStartY = startY / getLevelDownsample(level);
+  long long levelStartX = std::floor(startX / getLevelDownsample(level) + 0.5);
+  long long levelStartY = std::floor(startY / getLevelDownsample(level) + 0.5);
   long long startTileY = levelStartY-(levelStartY-((levelStartY/tileH)*tileH));
   long long startTileX = levelStartX-(levelStartX-((levelStartX/tileW)*tileW));
   long long finalX = levelStartX + width >= levelW ? levelW : levelStartX + width;
@@ -316,6 +316,23 @@ template <typename T> T* TIFFImage::FillRequestedRegionFromTIFF(const long long&
           TIFFGetField(_tiff, TIFFTAG_PHOTOMETRIC, &ycbcr);
           if (ycbcr == PHOTOMETRIC_YCBCR) {
             TIFFReadRGBATile(_tiff, ix, iy, (uint32*)tile);
+            unsigned char* tmp_row = new unsigned char[tileW*nrSamples];
+            for (unsigned int rev_y = 0; rev_y < tileH / 2; ++rev_y) {
+              std::copy(tile + rev_y*tileW*nrSamples, tile + (rev_y + 1)*tileW*nrSamples, tmp_row);
+              std::copy(tile + (tileH*tileW*nrSamples) - (rev_y + 1)*tileW*nrSamples, tile + (tileH*tileW*nrSamples) - rev_y*tileW*nrSamples, tile + rev_y*tileW*nrSamples);
+              std::copy(tmp_row, tmp_row + tileW*nrSamples, tile + (tileH*tileW*nrSamples) - (rev_y + 1)*tileW*nrSamples);
+            }
+            delete[] tmp_row;
+            for (unsigned int pos = 0; pos < tileW*tileH*nrSamples; pos += 4) {
+              unsigned char r = tile[pos + 0];
+              unsigned char g = tile[pos + 1];
+              unsigned char b = tile[pos + 2];
+              unsigned char a = tile[pos + 3];
+              tile[pos + 0] = b;
+              tile[pos + 1] = g;
+              tile[pos + 2] = r;
+              tile[pos + 3] = a;
+            }
           }
           else {
             TIFFReadTile(_tiff, tile, ix, iy, 0, 0);