From 3c1ee4152e36e690550ba3b15009ef0d92736640 Mon Sep 17 00:00:00 2001 From: Luca Leonardo Bologna Date: Thu, 11 Jun 2020 15:59:02 +0200 Subject: [PATCH] inserted links to data in masoli_et_al_2020b --- .../masoli_et_al_2020b/masoli_et_al_2020b.html | 18 ++++++++++++++++-- 1 file changed, 16 insertions(+), 2 deletions(-) diff --git a/2020/masoli_et_al_2020b/masoli_et_al_2020b.html b/2020/masoli_et_al_2020b/masoli_et_al_2020b.html index 72efc59..3c26345 100644 --- a/2020/masoli_et_al_2020b/masoli_et_al_2020b.html +++ b/2020/masoli_et_al_2020b/masoli_et_al_2020b.html @@ -106,8 +106,22 @@
Abstract:
The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. Although recent works have highlighted the complexity of their dendritic organization and synaptic inputs, the mechanisms through which these neurons integrate complex input patterns remained unknown. Here we have used 8 detailed morphological reconstructions to develop multicompartmental models of Golgi cells, in which Na, Ca, and K channels were distributed along dendrites, soma, axonal initial segment and axon. The models faithfully reproduced a rich pattern of electrophysiological and pharmacological properties and predicted the operating mechanisms of these neurons. Basal dendrites turned out to be more tightly electrically coupled to the axon initial segment than apical dendrites. During synaptic transmission, parallel fibers caused slow Ca-dependent depolarizations in apical dendrites that boosted the axon initial segment encoder and Na-spike backpropagation into basal dendrites, while inhibitory synapses effectively shunted backpropagating currents. This oriented dendritic processing set up a coincidence detector controlling voltage-dependent NMDA receptor unblock in basal dendrites, which, by regulating local calcium influx, may provide the basis for spike-timing dependent plasticity anticipated by theory.
Resources
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Electrophysiological data available in the HBP Knowledge Graph. - One of the models used in the paper is available at the links reported below, grouped into the following categories: +

Electrophysiological data available in the HBP Knowledge Graph and are listed below: +
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+ Whole cell patch-clamp recordings of cerebellar Golgi cells +
+ Recordings of cerebellar neuronal firing induced by currents steps +
+ Investigation of spatial distribution of excitation in cerebellar cortical slices +
+ Characterization of spatial distribution of activity in cerebellar cortical slices +
+ Recordings of spontaneous firing of cerebellar interneurons (Golgi cells) +
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+ One of the models used in the paper is available at the links reported below. Relevant files are grouped bye category below: +