diff --git a/spark-cassandra-connector/src/main/scala/org/apache/spark/sql/cassandra/BasicCassandraPredicatePushDown.scala b/spark-cassandra-connector/src/main/scala/org/apache/spark/sql/cassandra/BasicCassandraPredicatePushDown.scala
index e783901c6..1232f10fc 100644
--- a/spark-cassandra-connector/src/main/scala/org/apache/spark/sql/cassandra/BasicCassandraPredicatePushDown.scala
+++ b/spark-cassandra-connector/src/main/scala/org/apache/spark/sql/cassandra/BasicCassandraPredicatePushDown.scala
@@ -1,6 +1,7 @@
 package org.apache.spark.sql.cassandra
 
 import com.datastax.spark.connector.cql.TableDef
+import com.datastax.spark.connector.types.TimeUUIDType
 
 /**
  *  Determines which filter predicates can be pushed down to Cassandra.
@@ -61,6 +62,22 @@ class BasicCassandraPredicatePushDown[Predicate : PredicateOps](predicates: Set[
   private def firstNonEmptySet[T](sets: Set[T]*): Set[T] =
     sets.find(_.nonEmpty).getOrElse(Set.empty[T])
 
+
+  /** All non-equal predicates on a TimeUUID column are going to fail and fail
+    * in silent way. The basic issue here is that when you use a comparison on
+    * a time UUID column in C* it compares based on the Time portion of the UUID. When
+    * Spark executes this filter (unhandled behavior) it will compare lexically, this
+    * will lead to results being incorrectly filtered out of the set. As long as the
+    * range predicate is handled completely by the connector the correct result
+    * will be obtained.
+    */
+  val timeUUIDNonEqual = {
+    val timeUUIDCols = table.columns.filter(x => x.columnType == TimeUUIDType)
+    timeUUIDCols.flatMap(col => rangePredicatesByName.get(col.columnName)).flatten
+  }
+
+
+
   /**
    * Selects partition key predicates for pushdown:
    * 1. Partition key predicates must be equality or IN predicates.
@@ -137,4 +154,21 @@ class BasicCassandraPredicatePushDown[Predicate : PredicateOps](predicates: Set[
     * so they must be applied by Spark  */
   val predicatesToPreserve: Set[Predicate] =
     predicates -- predicatesToPushDown
+
+
+  val unhandledTimeUUIDNonEqual = {
+    timeUUIDNonEqual.toSet -- predicatesToPushDown
+  }
+
+  require(unhandledTimeUUIDNonEqual.isEmpty,
+    s"""
+      | You are attempting to do a non-equality comparison on a TimeUUID column in Spark.
+      | Spark can only compare TimeUUIDs Lexically which means that the comparison will be
+      | different than the comparison done in C* which is done based on the Time Portion of
+      | TimeUUID. This will in almost all cases lead to incorrect results. If possible restrict
+      | doing a TimeUUID comparison only to columns which can be pushed down to Cassandra.
+      | https://datastax-oss.atlassian.net/browse/SPARKC-405.
+      |
+      | $unhandledTimeUUIDNonEqual
+    """.stripMargin)
 }
diff --git a/spark-cassandra-connector/src/test/scala/org/apache/spark/sql/cassandra/PredicatePushDownSpec.scala b/spark-cassandra-connector/src/test/scala/org/apache/spark/sql/cassandra/PredicatePushDownSpec.scala
index 39ca44bd0..eabdc1ea5 100644
--- a/spark-cassandra-connector/src/test/scala/org/apache/spark/sql/cassandra/PredicatePushDownSpec.scala
+++ b/spark-cassandra-connector/src/test/scala/org/apache/spark/sql/cassandra/PredicatePushDownSpec.scala
@@ -1,9 +1,8 @@
 package org.apache.spark.sql.cassandra
 
-import org.scalatest.{Matchers, FlatSpec}
-
+import org.scalatest.{FlatSpec, Matchers}
 import com.datastax.spark.connector.cql._
-import com.datastax.spark.connector.types.IntType
+import com.datastax.spark.connector.types.{IntType, TimeUUIDType}
 
 class PredicatePushDownSpec extends FlatSpec with Matchers {
 
@@ -39,6 +38,9 @@ class PredicatePushDownSpec extends FlatSpec with Matchers {
   val i2 = ColumnDef("i2", RegularColumn, IntType)
   val r1 = ColumnDef("r1", RegularColumn, IntType)
   val r2 = ColumnDef("r2", RegularColumn, IntType)
+  val t1 = ColumnDef("t1", RegularColumn, TimeUUIDType)
+
+  val timeUUIDc1 = ColumnDef("c1", ClusteringColumn(0), TimeUUIDType)
 
   val table = TableDef(
     keyspaceName = "test",
@@ -51,6 +53,14 @@ class PredicatePushDownSpec extends FlatSpec with Matchers {
       IndexDef("DummyIndex", "i2", "IndexTwo", Map.empty))
   )
 
+  val timeUUIDTable = TableDef(
+    keyspaceName = "test",
+    tableName = "uuidtab",
+    partitionKey = Seq(pk1, pk2),
+    clusteringColumns = Seq(timeUUIDc1),
+    regularColumns = Seq(i1, i2, r1, r2, t1)
+  )
+
   "BasicCassandraPredicatePushDown" should "push down all equality predicates restricting partition key columns" in {
     val f1 = EqFilter("pk1")
     val f2 = EqFilter("pk2")
@@ -59,6 +69,28 @@ class PredicatePushDownSpec extends FlatSpec with Matchers {
     ppd.predicatesToPreserve shouldBe empty
   }
 
+  it should " break if the user tries to use a TimeUUID on a fully unhandled predicate" in {
+    val f1 = GtFilter("t1")
+
+    val ex = intercept[IllegalArgumentException] {
+      val ppd = new BasicCassandraPredicatePushDown(Set[Filter](f1), timeUUIDTable)
+    }
+  }
+
+  it should " work if the user tries to use a TimeUUID on a fully handled predicate" in {
+    val f1 = GtFilter("c1")
+    val ppd = new BasicCassandraPredicatePushDown(Set[Filter](f1), timeUUIDTable)
+    ppd.predicatesToPushDown should contain (f1)
+    ppd.predicatesToPreserve shouldBe empty
+  }
+
+  it should " work if the user tries to use a TimeUUID column in a eq predicate" in {
+    val f1 = EqFilter("c1")
+    val ppd = new BasicCassandraPredicatePushDown(Set[Filter](f1), timeUUIDTable)
+    ppd.predicatesToPushDown should contain (f1)
+    ppd.predicatesToPreserve shouldBe empty
+  }
+
   it should "not push down a partition key predicate for a part of the partition key" in {
     val f1 = EqFilter("pk1")
     val ppd1 = new BasicCassandraPredicatePushDown(Set[Filter](f1), table)