diff --git a/Pipfile b/Pipfile
index cf7abe9..a039031 100644
--- a/Pipfile
+++ b/Pipfile
@@ -5,9 +5,9 @@ name = "pypi"
 
 [packages]
 gotoh = {subdirectory = "micall/alignment", ref = "v7.7.0", git = "https://github.com/cfe-lab/MiCall.git"}
-numpy = "==1.22.0"
+numpy = "==1.25.1"
 python-levenshtein = "==0.12.0"
-pandas = "==1.0.5"
+pandas = "==2.0.2"
 requests = "==2.31.0"
 pyyaml = "*"
 
diff --git a/Pipfile.lock b/Pipfile.lock
index 1419fbb..5bc34d3 100644
--- a/Pipfile.lock
+++ b/Pipfile.lock
@@ -1,7 +1,7 @@
 {
     "_meta": {
         "hash": {
-            "sha256": "5c72a9aaf5677995fc3b707199a259fc9156fbd273b6fabe02953b9c1faad35d"
+            "sha256": "73432848a2ff11546bd4d06f2cabd2c46876a987e2d0a9e8c0d379cdfd9eb4f5"
         },
         "pipfile-spec": 6,
         "requires": {
@@ -26,84 +26,84 @@
         },
         "charset-normalizer": {
             "hashes": [
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-                "sha256:04eefcee095f58eaabe6dc3cc2262f3bcd776d2c67005880894f447b3f2cb9c1",
-                "sha256:0be65ccf618c1e7ac9b849c315cc2e8a8751d9cfdaa43027d4f6624bd587ab7e",
-                "sha256:0c95f12b74681e9ae127728f7e5409cbbef9cd914d5896ef238cc779b8152373",
-                "sha256:0ca564606d2caafb0abe6d1b5311c2649e8071eb241b2d64e75a0d0065107e62",
-                "sha256:10c93628d7497c81686e8e5e557aafa78f230cd9e77dd0c40032ef90c18f2230",
-                "sha256:11d117e6c63e8f495412d37e7dc2e2fff09c34b2d09dbe2bee3c6229577818be",
-                "sha256:11d3bcb7be35e7b1bba2c23beedac81ee893ac9871d0ba79effc7fc01167db6c",
-                "sha256:12a2b561af122e3d94cdb97fe6fb2bb2b82cef0cdca131646fdb940a1eda04f0",
-                "sha256:12d1a39aa6b8c6f6248bb54550efcc1c38ce0d8096a146638fd4738e42284448",
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+                "sha256:c4983bf937209c57240cff65906b18bb35e64ae872da6a0db937d7b4af845dd7",
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+                "sha256:eef9df1eefada2c09a5e7a40991b9fc6ac6ef20b1372abd48d2794a316dc0449",
+                "sha256:f058f6963fd82eb143c692cecdc89e075fa0828db2e5b291070485390b2f1c9c",
+                "sha256:f25c229a6ba38a35ae6e25ca1264621cc25d4d38dca2942a7fce0b67a4efe918",
+                "sha256:f2a1d0fd4242bd8643ce6f98927cf9c04540af6efa92323e9d3124f57727bfc1",
+                "sha256:f7560358a6811e52e9c4d142d497f1a6e10103d3a6881f18d04dbce3729c0e2c",
+                "sha256:f779d3ad205f108d14e99bb3859aa7dd8e9c68874617c72354d7ecaec2a054ac",
+                "sha256:f87f746ee241d30d6ed93969de31e5ffd09a2961a051e60ae6bddde9ec3583aa"
             ],
-            "markers": "python_version >= '3.7'",
-            "version": "==3.1.0"
+            "markers": "python_full_version >= '3.7.0'",
+            "version": "==3.2.0"
         },
         "gotoh": {
             "git": "https://github.com/cfe-lab/MiCall.git",
@@ -120,60 +120,72 @@
         },
         "numpy": {
             "hashes": [
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         "python-levenshtein": {
@@ -192,38 +204,49 @@
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@@ -235,95 +258,111 @@
         },
         "setuptools": {
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             "version": "==1.16.0"
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             "markers": "python_version >= '3.7'",
-            "version": "==2.0.2"
+            "version": "==2.0.4"
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     "develop": {
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+                "sha256:eb393e5ebc85245347950143969b241d08b52b88a3dc39479822e073a1a8eb27",
+                "sha256:ebba1cd308ef115925421d3e6a586e655ca5a77b5bf41e02eb0e4562a111f2d1",
+                "sha256:ee57190f24fba796e36bb6d3aa8a8783c643d8fa9760c89f7a98ab5455fbf818",
+                "sha256:f2f67fe12b22cd130d34d0ef79206061bfb5eda52feb6ce0dba0644e20a03cf4",
+                "sha256:f6951407391b639504e3b3be51b7ba5f3528adbf1a8ac3302b687ecababf929e",
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             ],
-            "markers": "python_version >= '3.7'",
-            "version": "==23.1.0"
+            "index": "pypi",
+            "version": "==7.2.7"
         },
-        "coverage": {
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             "hashes": [
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-                "sha256:970284a88b99673ccb2e4e334cfb38a10aab7cd44f7457564d11898a74b62d0a",
-                "sha256:972c85d205b51e30e59525694670de6a8a89691186012535f9d7dbaa230e42c3",
-                "sha256:9a1ef3b66e38ef8618ce5fdc7bea3d9f45f3624e2a66295eea5e57966c85909e",
-                "sha256:af0e781009aaf59e25c5a678122391cb0f345ac0ec272c7961dc5455e1c40066",
-                "sha256:b6d534e4b2ab35c9f93f46229363e17f63c53ad01330df9f2d6bd1187e5eaacf",
-                "sha256:b7895207b4c843c76a25ab8c1e866261bcfe27bfaa20c192de5190121770672b",
-                "sha256:c0891a6a97b09c1f3e073a890514d5012eb256845c451bd48f7968ef939bf4ae",
-                "sha256:c2723d347ab06e7ddad1a58b2a821218239249a9e4365eaff6649d31180c1669",
-                "sha256:d1f8bf7b90ba55699b3a5e44930e93ff0189aa27186e96071fac7dd0d06a1873",
-                "sha256:d1f9ce122f83b2305592c11d64f181b87153fc2c2bbd3bb4a3dde8303cfb1a6b",
-                "sha256:d314ed732c25d29775e84a960c3c60808b682c08d86602ec2c3008e1202e3bb6",
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-                "sha256:ebe78fe9a0e874362175b02371bdfbee64d8edc42a044253ddf4ee7d3c15212c",
-                "sha256:f030f8873312a16414c0d8e1a1ddff2d3235655a2174e3648b4fa66b3f2f1079",
-                "sha256:f0b278ce10936db1a37e6954e15a3730bea96a0997c26d7fee88e6c396c2086d",
-                "sha256:f11642dddbb0253cc8853254301b51390ba0081750a8ac03f20ea8103f0c56b6"
+                "sha256:12c3e887d6485d16943a309616de20ae5582633e0a2eda17f4e10fd61c1e8af5",
+                "sha256:e346e69d186172ca7cf029c8c1d16235aa0e04035e5750b4b95039e65204328f"
             ],
-            "index": "pypi",
-            "version": "==5.5"
+            "markers": "python_version < '3.11'",
+            "version": "==1.1.2"
         },
         "iniconfig": {
             "hashes": [
@@ -343,35 +382,27 @@
         },
         "pluggy": {
             "hashes": [
-                "sha256:15b2acde666561e1298d71b523007ed7364de07029219b604cf808bfa1c765b0",
-                "sha256:966c145cd83c96502c3c3868f50408687b38434af77734af1e9ca461a4081d2d"
+                "sha256:c2fd55a7d7a3863cba1a013e4e2414658b1d07b6bc57b3919e0c63c9abb99849",
+                "sha256:d12f0c4b579b15f5e054301bb226ee85eeeba08ffec228092f8defbaa3a4c4b3"
             ],
-            "markers": "python_version >= '2.7' and python_version not in '3.0, 3.1, 3.2, 3.3'",
-            "version": "==0.13.1"
-        },
-        "py": {
-            "hashes": [
-                "sha256:51c75c4126074b472f746a24399ad32f6053d1b34b68d2fa41e558e6f4a98719",
-                "sha256:607c53218732647dff4acdfcd50cb62615cedf612e72d1724fb1a0cc6405b378"
-            ],
-            "markers": "python_version >= '2.7' and python_version not in '3.0, 3.1, 3.2, 3.3, 3.4'",
-            "version": "==1.11.0"
+            "markers": "python_version >= '3.7'",
+            "version": "==1.2.0"
         },
         "pytest": {
             "hashes": [
-                "sha256:50bcad0a0b9c5a72c8e4e7c9855a3ad496ca6a881a3641b4260605450772c54b",
-                "sha256:91ef2131a9bd6be8f76f1f08eac5c5317221d6ad1e143ae03894b862e8976890"
+                "sha256:78bf16451a2eb8c7a2ea98e32dc119fd2aa758f1d5d66dbf0a59d69a3969df32",
+                "sha256:b4bf8c45bd59934ed84001ad51e11b4ee40d40a1229d2c79f9c592b0a3f6bd8a"
             ],
             "index": "pypi",
-            "version": "==6.2.4"
+            "version": "==7.4.0"
         },
-        "toml": {
+        "tomli": {
             "hashes": [
-                "sha256:806143ae5bfb6a3c6e736a764057db0e6a0e05e338b5630894a5f779cabb4f9b",
-                "sha256:b3bda1d108d5dd99f4a20d24d9c348e91c4db7ab1b749200bded2f839ccbe68f"
+                "sha256:939de3e7a6161af0c887ef91b7d41a53e7c5a1ca976325f429cb46ea9bc30ecc",
+                "sha256:de526c12914f0c550d15924c62d72abc48d6fe7364aa87328337a31007fe8a4f"
             ],
-            "markers": "python_version >= '2.6' and python_version not in '3.0, 3.1, 3.2, 3.3'",
-            "version": "==0.10.2"
+            "markers": "python_version < '3.11'",
+            "version": "==2.0.1"
         }
     }
 }
diff --git a/setup.py b/setup.py
index fc41321..069adcc 100644
--- a/setup.py
+++ b/setup.py
@@ -6,9 +6,9 @@
     packages=find_packages(),
     install_requires=[
         'gotoh @ git+https://github.com/cfe-lab/MiCall.git@v7.7.0#egg=gotoh&subdirectory=micall/alignment',
-        'numpy==1.22.0',
+        'numpy==1.25.1',
         'python-Levenshtein==0.12.0',
-        'pandas==1.0.5',
+        'pandas==2.0.2',
         'requests==2.31.0',
         'pyyaml'
     ],