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HLA/MHC region should be skipped by default #15

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quattro opened this issue Jul 25, 2019 · 0 comments
Open

HLA/MHC region should be skipped by default #15

quattro opened this issue Jul 25, 2019 · 0 comments
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@quattro
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quattro commented Jul 25, 2019

FOCUS will perform association testing and fine-mapping at the HLA/MHC region by default. Due to the pervasive LD at this region it is troublesome both computationally and statistically.

FOCUS should operate similarly to FUSION and skip this region by default. I think adding a flag to explicitly include it, along with a warning/log message upon startup, would be useful.

@quattro quattro self-assigned this Jul 25, 2019
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