diff --git a/conda-recipe/meta.yaml b/conda-recipe/meta.yaml
index f33d4c8a7b8..7a7ba552598 100644
--- a/conda-recipe/meta.yaml
+++ b/conda-recipe/meta.yaml
@@ -61,7 +61,7 @@ requirements:
     - pandas >=1.4.0,!=1.5.0,!=2.0.0
     - pyyaml
     - orange-canvas-core >=0.1.30,<0.2a
-    - orange-widget-base >=4.20.0
+    - orange-widget-base >=4.21.0
     - openpyxl
     - httpx >=0.21
     - baycomp >=1.0.2
diff --git a/requirements-gui.txt b/requirements-gui.txt
index 52392deb7b8..12466671d8e 100644
--- a/requirements-gui.txt
+++ b/requirements-gui.txt
@@ -1,5 +1,5 @@
 orange-canvas-core>=0.1.30,<0.2a
-orange-widget-base>=4.20.0
+orange-widget-base>=4.21.0
 
 AnyQt>=0.2.0
 
diff --git a/tox.ini b/tox.ini
index 376f8f9a4a7..21f5e88f041 100644
--- a/tox.ini
+++ b/tox.ini
@@ -39,7 +39,7 @@ deps =
     latest: https://github.com/biolab/orange-canvas-core/archive/refs/heads/master.zip#egg=orange-canvas-core
     latest: https://github.com/biolab/orange-widget-base/archive/refs/heads/master.zip#egg=orange-widget-base
     oldest: orange-canvas-core==0.1.30
-    oldest: orange-widget-base==4.20.0
+    oldest: orange-widget-base==4.21.0
     oldest: AnyQt==0.2.0
     oldest: pyqtgraph>=0.13.1
     oldest: matplotlib==3.2.0