diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 82a52c8ecf..eda95f2d19 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -158,6 +158,15 @@ jobs:
           python -m pip install --upgrade pip
           python -m pip install --upgrade tox
 
+      - name: Install pymssql on macOS
+        if: matrix.os == 'macos-latest' && matrix.python-version >= '3.11'
+        run: |
+          brew install FreeTDS
+          export CFLAGS="-I$(brew --prefix openssl)/include  -I$(brew --prefix freetds)/include"
+          export LDFLAGS="-L$(brew --prefix openssl)/lib  -L$(brew --prefix freetds)/lib"
+          export CPPFLAGS="-I$(brew --prefix openssl)/include -I$(brew --prefix freetds)/include"
+          pip install --pre --no-binary :all: pymssql --no-cache --force
+
       - name: Test with Tox
         run: |
           tox -e ${{ matrix.tox_env }}
diff --git a/tox.ini b/tox.ini
index c98e12d15a..d907c8ca62 100644
--- a/tox.ini
+++ b/tox.ini
@@ -5,7 +5,7 @@ envlist =
     build_doc
     add-ons
 skip_missing_interpreters = true
-isolated_build = true
+isolated_build = platform_system!="Darwin"  # pymssql is installed before tox runs
 
 [testenv]
 # https://tox.wiki/en/latest/config.html#download
@@ -32,7 +32,7 @@ deps =
     pyqtwebengine==5.15.*;platform_system!="Windows" or python_version>='3.10'
     coverage
     psycopg2-binary
-    pymssql;platform_system!="Darwin" or python_version>="3.11"
+    pymssql;platform_system!="Darwin"
     latest: https://github.com/biolab/orange-canvas-core/archive/refs/heads/master.zip#egg=orange-canvas-core
     latest: https://github.com/biolab/orange-widget-base/archive/refs/heads/master.zip#egg=orange-widget-base
     # GUI requirements