diff --git a/DESCRIPTION b/DESCRIPTION index 0918573..fea2589 100755 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,7 +1,7 @@ Package: MTXmodel Title: Statistical approaches for differential expression analysis in metatranscriptomics Year: 2021 -Version: 1.2.4 +Version: 1.2.5 Authors@R: c( person("Yancong", "Zhang", email = "zhangyc201211@gmail.com", role = "aut"), person("Eric", "Franzosa", email = "franzosa@hsph.harvard.edu", role = c("aut", "cre")) diff --git a/NEWS b/NEWS index 83faf22..29a324b 100755 --- a/NEWS +++ b/NEWS @@ -1,6 +1,9 @@ # MTXmodel History # +## Changes in v1.2.5 (2024-07-10) ## +* Tweaked formula + ## Changes in v1.2.4 (2023-09-07) ## * Fixed xtfrm warning message * Add log info if there is no result diff --git a/R/utility_ext.R b/R/utility_ext.R index 19709ba..6982d92 100755 --- a/R/utility_ext.R +++ b/R/utility_ext.R @@ -409,8 +409,7 @@ fit.each <- function( mydf <- data.frame(expr = features[,i], mymeta) formula_text <- - paste("expr ~ ", paste(colnames(mymeta), collapse = " + ")) - #logging::loginfo("Formula for fixed effects: %s", formula_text) + paste("expr ~ ", paste(c(fixed_effects, i), collapse = " + ")) formula <- tryCatch( as.formula(formula_text), @@ -539,7 +538,7 @@ fit.dnadata <- model, fixed_effects, effects_names, - random_effects_formula = NULL) + random_effects_formula) # bind the results for each feature diff --git a/test/demo_output/all_results.tsv b/test/demo_output/all_results.tsv index f2e7985..72cf7c4 100644 --- a/test/demo_output/all_results.tsv +++ b/test/demo_output/all_results.tsv @@ -1,1247 +1,1247 @@ feature metadata value coef stderr N N.not.0 pval qval -PWY_3841_folate_transformations_II diagnosis CD 3.05264527781524 0.430985950029145 803 787 3.61738181822429e-12 4.50725774550747e-09 -PWY_3841_folate_transformations_II diagnosis UC 2.90870524420221 0.431254803599096 803 787 3.34531003818098e-11 2.08412815378675e-08 -X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn diagnosis CD 3.59440522356882 0.540171132819528 803 779 5.97629898949736e-11 2.48215618030457e-08 -X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn diagnosis UC 3.51473800874412 0.538121663422411 803 779 1.29827121887383e-10 4.04411484679198e-08 -CALVIN_PWY_Calvin_Benson_Bassham_cyc age age -1.55163723974623 0.249165778277949 803 797 8.4372711832359e-10 2.10256797886239e-07 -GLYCOLYSIS_glycolysis_I age age -1.91069486459255 0.321573694621591 803 791 4.56619790930333e-09 8.51619343089558e-07 -PWY_5484_glycolysis_II age age -1.91565675199371 0.322846957546807 803 791 4.78437833196381e-09 8.51619343089558e-07 -NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I dysbiosisCD Yes -0.619799571558971 0.107065708466986 803 799 1.09385528559008e-08 1.70367960730655e-06 -CITRULBIO_PWY_L_citrulline_biosyn age age -4.50467126593872 0.837735443079392 803 688 1.0627599422361e-07 1.47133209780687e-05 -PWY_7208_SP_of_pyrimidine_nucleobases_salvage dysbiosisCD Yes -0.860041096160099 0.175456636233516 803 794 1.19612433388056e-06 0.000149037092001518 -PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn diagnosis UC 2.89165791890938 0.594287653334792 803 761 1.42750676370609e-06 0.000151717995114039 -PWY_5973_cis_vaccenate_biosyn diagnosis CD 2.54673171086829 0.523928076081053 803 787 1.46116849227004e-06 0.000151717995114039 -PWY_5030_L_histidine_deg_III diagnosis CD 5.73001198432264 1.23521594718485 803 542 4.27162072802911e-06 0.000409418417471098 -PWY0_1261_anhydromuropeptides_recycling dysbiosisCD Yes 2.53318093907947 0.559249509027303 803 273 7.2596551199336e-06 0.00064610930567409 -ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn age age -1.25178429938323 0.279807431283327 803 797 9.04872334356394e-06 0.000751647285738711 -PWY_5973_cis_vaccenate_biosyn diagnosis UC 2.32540615901983 0.52325524833308 803 787 1.03451127547391e-05 0.000758835294683263 -PANTO_PWY_phosphopantothenate_biosyn_I diagnosis UC 1.44372703155645 0.325804728296912 803 798 1.09623076278481e-05 0.000758835294683263 -PWY66_399_gluconeogenesis_III diagnosis CD 6.04806305349189 1.36377590715738 803 670 1.09505610366371e-05 0.000758835294683263 -PWY_5097_L_lysine_biosyn_VI age age -0.84092619096776 0.190821056640455 803 802 1.22315657368691e-05 0.000802133205691521 -COA_PWY_1_coenzyme_A_biosyn_II age age -0.894160839442632 0.205012594321544 803 800 1.49782851050512e-05 0.000898120457073534 -P42_PWY_incomplete_reductive_TCA_cyc diagnosis UC 4.58674887536774 1.05207317178604 803 636 1.51368616360708e-05 0.000898120457073534 -P42_PWY_incomplete_reductive_TCA_cyc diagnosis CD 4.54316714488461 1.05297074058615 803 636 1.84761377257503e-05 0.00104642125483113 -PWY_5173_SP_of_acetyl_CoA_biosyn dysbiosisCD Yes 2.45646853902419 0.569965497424357 803 335 2.10519476890312e-05 0.00109540187322775 -THRESYN_PWY_SP_of_L_threonine_biosyn age age -0.939938461696995 0.219417947657785 803 796 2.1099233513215e-05 0.00109540187322775 -PWY_5104_L_isoleucine_biosyn_IV diagnosis UC 6.61922933230559 1.584008293303 803 475 3.34223522701199e-05 0.00166577003714278 -PWY_6270_isoprene_biosyn_I diagnosis CD -4.82832342229654 1.16744663660977 803 219 4.15157261275681e-05 0.00198956133672884 -PWY_6270_isoprene_biosyn_I diagnosis UC -4.57868762026299 1.11428605970566 803 219 4.64445006001409e-05 0.00214332769436206 -PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III diagnosis CD 4.8188357527129 1.18304304102523 803 512 5.21326642576504e-05 0.00231990355946544 -PWY_7560_methylerythritol_phosphate_pwy_II diagnosis UC -4.64838840212083 1.14269111652326 803 226 5.50399498896967e-05 0.00236481991595042 -PWY_7560_methylerythritol_phosphate_pwy_II diagnosis CD -4.86209868352207 1.19838027557836 803 226 5.75396281077443e-05 0.00238981255407498 -PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II age age -0.924899860755534 0.229193123941066 803 794 6.08585257120644e-05 0.00244612009797523 -PWY_5030_L_histidine_deg_III age age -4.006571614609 1.00531111654908 803 542 7.53392934439302e-05 0.00293352373847303 -PWY_5104_L_isoleucine_biosyn_IV diagnosis CD 6.83653027492091 1.75613908708234 803 475 0.000109532961573144 0.00413569909454962 -PWY_4984_urea_cyc age age -3.24500214112581 0.836888834131598 803 665 0.000116526663527911 0.00427035949281697 -PWY_7234_inosine_5_phosphate_biosyn_III diagnosis CD 3.66387364521536 0.947495658666683 803 690 0.000121454108054917 0.00432180953694728 -PWY_4981_L_proline_biosyn_II age age -3.69088798112847 0.956435971838758 803 678 0.000125173220959615 0.00432180953694728 -PWY_5695_urate_biosyn_inosine_5_phosphate_deg diagnosis CD -1.09147586518176 0.283323129844316 803 800 0.000128336238256059 0.00432180953694728 -PWY0_1298_SP_of_pyrimidine_dns_deg dysbiosisCD Yes 1.93424214651984 0.508368320472545 803 455 0.000155727667902413 0.00510622826858965 -PWY_7219_adenosine_rnt_de_novo_biosyn diagnosis UC 0.719678808331744 0.190062998721482 803 803 0.000166653867081599 0.00532437739445314 -PWY_6700_queuosine_biosyn age age -1.69997036358819 0.454100156435154 803 780 0.000197174285195135 0.00602136073382484 -PWY_6385_peptidoglycan_biosyn_III diagnosis CD -0.94911418813798 0.253614098624703 803 797 0.000198134662991026 0.00602136073382484 -PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn diagnosis CD 2.21078962367496 0.596816559987309 803 761 0.000229719234415315 0.00681500395432101 -UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I dysbiosisCD Yes 1.71986293164518 0.465725359355046 803 503 0.000241233395689314 0.00699015839602059 -PANTO_PWY_phosphopantothenate_biosyn_I diagnosis CD 1.21536624181284 0.330379001829484 803 798 0.000253469767040968 0.00717780294847832 -PYRIDNUCSYN_PWY_NAD_biosyn_I diagnosis CD 3.22230084463242 0.877410025793593 803 707 0.000259714496816464 0.00719120584518476 -NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I age age -0.737422040505187 0.202351284619737 803 799 0.000289164529975962 0.00766593626276699 -PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn dysbiosisCD Yes -0.883407698388729 0.242395732716899 803 761 0.000288988859095824 0.00766593626276699 -PWY_2941_L_lysine_biosyn_II age age -2.92402992998588 0.834673533041073 803 454 0.000495438892156846 0.0128607679089048 -PENTOSE_P_PWY_pentose_phosphate_pwy age age -2.98538673385792 0.856939269621536 803 613 0.000527843539804927 0.0134223071550396 -PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I dysbiosisUC Yes 0.952462475525758 0.273883379309548 803 783 0.000538997350617736 0.013431813977394 -PWY_5686_UMP_biosyn dysbiosisCD Yes -0.308378461663188 0.0894424904514181 803 802 0.000601001705877024 0.0146832965788779 -PWY_7219_adenosine_rnt_de_novo_biosyn age age 0.496309066732929 0.144761083391296 803 803 0.000644623125238673 0.0152150957286576 -PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I age age -3.52023680621959 1.02736918984254 803 561 0.000650167768385146 0.0152150957286576 -PWY0_1298_SP_of_pyrimidine_dns_deg diagnosis CD -4.34099914059772 1.26837832567822 803 455 0.000660654978977823 0.0152150957286576 -PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I dysbiosisCD Yes -0.689885460946274 0.201890842276778 803 783 0.000671613374860489 0.0152150957286576 -PWY_7234_inosine_5_phosphate_biosyn_III age age -2.84541483739069 0.83729838662225 803 690 0.000719922369350866 0.0160182727180568 -PWY_5177_glutaryl_CoA_deg diagnosis CD -2.8429444817405 0.838760723129377 803 753 0.000742589547321644 0.0162048970659599 -PWY_5667_CDP_diacylglycerol_biosyn_I age age 0.635520604640089 0.1880218084069 803 801 0.000767326586590396 0.0162048970659599 -PWY0_1319_CDP_diacylglycerol_biosyn_II age age 0.635533035677839 0.188022589190229 803 801 0.000767183692095801 0.0162048970659599 -PWY_2942_L_lysine_biosyn_III diagnosis CD 0.727956187427275 0.218281944107439 803 802 0.00090081217987231 0.0187068662686816 -ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn dysbiosisCD Yes 0.488894735909724 0.147369881235348 803 797 0.000958155325550911 0.0193169295157941 -PWY_7219_adenosine_rnt_de_novo_biosyn diagnosis CD 0.629882187598775 0.189921222069065 803 803 0.000961195529678357 0.0193169295157941 -PWY_5659_GDP_mannose_biosyn diagnosis UC 1.91445741201464 0.58019152796475 803 788 0.00101986077015171 0.0199535885325577 -HISDEG_PWY_L_histidine_deg_I diagnosis CD 5.59455184339377 1.69569530739145 803 582 0.00102490342382319 0.0199535885325577 -PWY_5973_cis_vaccenate_biosyn dysbiosisnonIBD Yes 0.986871834356668 0.301215772344267 803 787 0.00110668444085557 0.0212142894354775 -VALSYN_PWY_L_valine_biosyn dysbiosisUC Yes 0.547183944636882 0.168898335223445 803 802 0.00125632160648856 0.0237178291164355 -FUCCAT_PWY_fucose_deg dysbiosisCD Yes 2.09546902585702 0.64779770989028 803 268 0.00129381579525379 0.0237393275194931 -P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate dysbiosisCD Yes 2.05647029061842 0.636325236234828 803 283 0.00129556522578293 0.0237393275194931 -PWY_6270_isoprene_biosyn_I dysbiosisCD Yes 1.50663019915754 0.46905648164226 803 219 0.00140320433998637 0.0253390232988843 -GLYCOGENSYNTH_PWY_glycogen_biosyn_I age age -2.71560097747057 0.848932240458901 803 706 0.00144572825039491 0.0257339628570294 -CALVIN_PWY_Calvin_Benson_Bassham_cyc diagnosis UC -1.02658096567356 0.321982602598031 803 797 0.00149859521360012 0.0262992906499401 -PWY_621_sucrose_deg_III dysbiosisCD Yes -1.17423717291385 0.370905925935554 803 741 0.00161719401416685 0.0276764038072357 -PWY_1042_glycolysis_IV dysbiosisCD Yes -0.30328634670591 0.0958226851730958 803 803 0.00162149075275137 0.0276764038072357 -P161_PWY_acetylene_deg age age -3.02542008914272 0.961721914890558 803 537 0.00173184582410071 0.0291605391463444 -PWY_7111_pyruvate_fermentation_to_isobutanol dysbiosisUC Yes 0.516847692315988 0.164858623937742 803 801 0.0017939863678546 0.0297588780076742 -PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I diagnosis CD 3.90050307986649 1.24541980406605 803 561 0.00181514825728992 0.0297588780076742 -PWY_5083_NAD_NADH_phosphorylation__dephosphorylation dysbiosisCD Yes 1.66859427489807 0.536140430157867 803 431 0.00196822227352741 0.0312749825384791 -PWY_6969_TCA_cyc_V diagnosis CD 3.68682052667717 1.18730995309351 803 403 0.00199374548177721 0.0312749825384791 -GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg dysbiosisCD Yes 1.93160121410915 0.621362027351549 803 300 0.00200540945835368 0.0312749825384791 -COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn diagnosis UC -1.59196484491283 0.513304459844149 803 773 0.00200802456105805 0.0312749825384791 -PWY_5030_L_histidine_deg_III antibiotics Yes -1.331164557424 0.430282314814207 803 542 0.00206527500779591 0.0314803134623406 -PWY_5676_acetyl_CoA_fermentation_to_butanoate_II diagnosis CD 5.17245246123787 1.67132410421765 803 459 0.00207173812512996 0.0314803134623406 -THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III age age -1.99009547946184 0.644699066724266 803 682 0.00210743241141135 0.031636876923115 -PWY_6163_chorismate_biosyn_from_3_dehydroquinate diagnosis UC -1.65720591123994 0.540044875876204 803 787 0.00223829578787553 0.0328550108452482 -PWY_5083_NAD_NADH_phosphorylation__dephosphorylation age age -3.33450800598892 1.08590875920207 803 431 0.00225741382250582 0.0328550108452482 -PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage dysbiosisUC Yes -1.28939740805081 0.420704191342603 803 754 0.00226768132639755 0.0328550108452482 -PWYG_321_mycolate_biosyn dysbiosisUC Yes -2.4500585049096 0.803259092992068 803 484 0.00239301766514847 0.0342724139169539 -GLUCONEO_PWY_gluconeogenesis_I diagnosis CD 5.03529285759158 1.65238995794544 803 457 0.00244482077666952 0.034616439633298 -PWY_6609_adenine__adenosine_salvage_III diagnosis CD -1.32741692017642 0.436928295248414 803 792 0.00247473373978491 0.0346462723569887 -PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage age age -1.65871634778509 0.550730514135276 803 754 0.00269713331202983 0.0373403122976574 -GALACTUROCAT_PWY_D_galacturonate_deg_I diagnosis CD -1.91063943444158 0.635655652193639 803 776 0.00274924420077012 0.0376423687564666 -PWY66_399_gluconeogenesis_III diagnosis UC 3.86295109936287 1.28614877824689 803 670 0.00277937233193814 0.0376423687564666 -RIBOSYN2_PWY_flavin_biosyn_I dysbiosisCD Yes 1.39207200954757 0.464822971301858 803 478 0.00285981798828419 0.0382991070699835 -NONOXIPENT_PWY_pentose_phosphate_pwy dysbiosisCD Yes -0.436121647516736 0.145839491369122 803 800 0.00288933873561673 0.0382991070699835 -HISTSYN_PWY_L_histidine_biosyn diagnosis UC 2.31048840137836 0.774997367996051 803 698 0.00297592748253542 0.038625058783741 -PWY_1042_glycolysis_IV diagnosis CD -0.672640853289993 0.225597997873084 803 803 0.00297284328891875 0.038625058783741 -PWY_5690_TCA_cyc_II diagnosis CD -3.93724739511105 1.33199377104953 803 363 0.00323715268691119 0.0413484474980901 -PWY_4984_urea_cyc dysbiosisUC Yes -1.72826436516925 0.585053970736899 803 665 0.00325246119535355 0.0413484474980901 -CALVIN_PWY_Calvin_Benson_Bassham_cyc diagnosis CD -0.948872334037213 0.321601978015978 803 797 0.0032853100339574 0.0413484474980901 -PWY_7234_inosine_5_phosphate_biosyn_III diagnosis UC 2.76953007255583 0.941779868291383 803 690 0.00339214110702896 0.0414905711081256 -PWY_7560_methylerythritol_phosphate_pwy_II dysbiosisCD Yes 1.41291689083353 0.480017212880122 803 226 0.00339522687459724 0.0414905711081256 -PWY_6163_chorismate_biosyn_from_3_dehydroquinate age age -1.22975753689499 0.418417864697069 803 787 0.00340684830750579 0.0414905711081256 -PWY0_1297_SP_of_purine_dns_deg diagnosis UC -3.34235158187466 1.13801354699121 803 610 0.0034297984142351 0.0414905711081256 -PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I age age -1.66654854209283 0.571171438662267 803 765 0.00364622324545134 0.0436845592676189 -PWY_5097_L_lysine_biosyn_VI dysbiosisCD Yes -0.288387684758922 0.0991677046790489 803 802 0.00375833922680458 0.0445652598794044 -PWY_5154_L_arginine_biosyn_III diagnosis CD 3.48441699173201 1.19919166865325 803 475 0.00379126608925912 0.0445652598794044 -PWY_5695_urate_biosyn_inosine_5_phosphate_deg dysbiosisUC Yes -0.445826669632914 0.154545167831939 803 800 0.00404441351487615 0.0470966284068755 -X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn dysbiosisCD Yes -0.612828784080733 0.212695401192953 803 779 0.00408922706723582 0.047177564127554 -GLYOXYLATE_BYPASS_glyoxylate_cyc diagnosis CD 5.96772764671664 2.09462424733514 803 255 0.0046305846462502 0.0522655909084256 -TCA_TCA_cyc_I dysbiosisCD Yes 1.4143995365867 0.497717761871118 803 412 0.00464278312975318 0.0522655909084256 -PWY0_1586_peptidoglycan_maturation diagnosis UC -2.4571382936522 0.865316239309403 803 773 0.00465608394128029 0.0522655909084256 -ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn age age -1.20089070796135 0.424030923830307 803 732 0.00477647493826893 0.0531382836882418 -HISDEG_PWY_L_histidine_deg_I diagnosis UC 5.01586071599512 1.77553760460812 803 582 0.00488046275144427 0.0536703585190257 -GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisCD Yes 1.25549995101894 0.44484025766632 803 706 0.00491045013737474 0.0536703585190257 -PWYG_321_mycolate_biosyn dysbiosisCD Yes -1.74303573870379 0.618895669964247 803 484 0.00502436702387348 0.0544379244499683 -ARO_PWY_chorismate_biosyn_I diagnosis UC -1.53359274374935 0.545890878522736 803 775 0.00511106611896567 0.0548998998640623 -FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation dysbiosisUC Yes -2.06308105711701 0.740024275964381 803 539 0.00547680924019979 0.0578042272302705 -PWY0_1261_anhydromuropeptides_recycling dysbiosisnonIBD Yes 2.51240258107829 0.901285746833122 803 273 0.00549503689381399 0.0578042272302705 -HISTSYN_PWY_L_histidine_biosyn age age 1.68776731521395 0.606209401778404 803 698 0.00552062844334044 0.0578042272302705 -DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I dysbiosisCD Yes -0.459428084188009 0.166621063765707 803 790 0.00598860606704485 0.062181692996149 -NAGLIPASYN_PWY_lipid_IVA_biosyn diagnosis CD 3.07120780530194 1.11942012019399 803 601 0.0062535693501001 0.0640221986433617 -PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III age age -2.83976958514902 1.03550843617897 803 512 0.0062686261914046 0.0640221986433617 -PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I diagnosis CD -0.475714544997513 0.174487379785264 803 799 0.00657329031693522 0.0665879653244007 -CALVIN_PWY_Calvin_Benson_Bassham_cyc dysbiosisCD Yes -0.370700414722683 0.136374777759911 803 797 0.0067349606716076 0.0676754919098635 -PWY_7221_guanosine_rnt_de_novo_biosyn diagnosis UC 0.533682479302856 0.197650540597453 803 802 0.00710833936697873 0.070855926810044 -PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I diagnosis CD 1.70476936987922 0.636224984427994 803 762 0.0075563436847742 0.0742598318719255 -PWY66_409_SP_of_purine_nt_salvage dysbiosisCD Yes 1.21581005566826 0.453713389198176 803 290 0.00756901978148839 0.0742598318719255 -PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I diagnosis CD -0.480286445268109 0.179680743986461 803 799 0.00770288944946652 0.0749828144846506 -PWY_6609_adenine__adenosine_salvage_III diagnosis UC -1.16333420477748 0.43675497077132 803 792 0.00791937381167113 0.0764925563514901 -PWY_841_SP_of_purine_nt_de_novo_biosyn_I diagnosis UC 3.04836132220398 1.15421852323589 803 651 0.00846180195156154 0.0811031171665052 -PWY_7221_guanosine_rnt_de_novo_biosyn dysbiosisUC Yes 0.284590745874492 0.108229752445835 803 802 0.00874952781027188 0.0828792798683633 -PWY_7456_mannan_deg age age 1.56670407383874 0.595162697794659 803 210 0.00878014842907219 0.0828792798683633 -PWY_7221_guanosine_rnt_de_novo_biosyn antibiotics Yes 0.180991354912172 0.0690526360897559 803 802 0.00896685388047396 0.0835273237767145 -NONOXIPENT_PWY_pentose_phosphate_pwy age age 0.704279354653536 0.268762893956953 803 800 0.00898287430664506 0.0835273237767145 -PWY_5690_TCA_cyc_II dysbiosisCD Yes 1.4775866614899 0.566843883870559 803 363 0.00936417036967852 0.0864278243008847 -PWY_7219_adenosine_rnt_de_novo_biosyn antibiotics Yes 0.170739858277942 0.0655946178140567 803 803 0.00944939842739257 0.0865436545391461 -PYRIDNUCSYN_PWY_NAD_biosyn_I diagnosis UC 2.28596207530267 0.879585922482971 803 707 0.00956199087352787 0.0865436545391461 -TRNA_CHARGING_PWY_tRNA_charging diagnosis UC 2.45677359856966 0.945614885417257 803 703 0.00958509175473689 0.0865436545391461 -PWY_5686_UMP_biosyn diagnosis UC 0.568445257469621 0.219298787170743 803 802 0.00974956192774976 0.087395353683282 -PWY_7456_mannan_deg dysbiosisUC Yes 1.6789343055371 0.649387743993936 803 210 0.010050616054872 0.0891950416322004 -PWY_5690_TCA_cyc_II diagnosis UC -3.41360337953948 1.32278781013086 803 363 0.0100934998957787 0.0891950416322004 -PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II age age -0.422387316594344 0.164685388587168 803 798 0.010542761779585 0.0925090223757951 -PWY_5676_acetyl_CoA_fermentation_to_butanoate_II age age -3.48203436364371 1.35975630584861 803 459 0.0107155330445155 0.0931195491307281 -PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II dysbiosisCD Yes -0.220541178863587 0.0862655546178387 803 798 0.0107942965501293 0.0931195491307281 -PWY_7664_oleate_biosyn_IV dysbiosisUC Yes -1.9532148364336 0.765372181949336 803 531 0.0109625901451874 0.0931195491307281 -PWY_7221_guanosine_rnt_de_novo_biosyn dysbiosisCD Yes -0.202799190104736 0.079638206663245 803 802 0.01110603727809 0.0931195491307281 -PWY_6700_queuosine_biosyn diagnosis CD 1.61710211776164 0.635275383683058 803 780 0.0111373500321734 0.0931195491307281 -P161_PWY_acetylene_deg dysbiosisCD Yes 1.23799452886457 0.486459453840077 803 537 0.0111610355056048 0.0931195491307281 -PWY_5484_glycolysis_II dysbiosisUC Yes -0.584613800709197 0.22975394890982 803 791 0.0111694192587447 0.0931195491307281 -PWY_5723_Rubisco_shunt age age -3.19955083425621 1.25483001882651 803 212 0.0112506810877701 0.0931195491307281 -PWY_841_SP_of_purine_nt_de_novo_biosyn_I dysbiosisnonIBD Yes 1.80358551567498 0.70980928036555 803 651 0.0112849533858266 0.0931195491307281 -PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn antibiotics Yes -0.891212704313458 0.352882966737514 803 469 0.0117896909053057 0.0966444399211244 -CITRULBIO_PWY_L_citrulline_biosyn dysbiosisUC Yes -1.47150860291564 0.585496500536171 803 688 0.0122071998375724 0.0994128823373543 -PWY_5188_tetrapyrrole_biosyn_I age age -1.73170726638829 0.690130705438622 803 731 0.0123373869021563 0.0998206758447192 -PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I diagnosis UC 1.58112186881966 0.635664214543089 803 762 0.0131148475814906 0.104880210182633 -PWY_6282_palmitoleate_biosyn_I dysbiosisUC Yes -1.92380604648686 0.773313313788378 803 531 0.0131310696536844 0.104880210182633 -PWY_5723_Rubisco_shunt dysbiosisCD Yes 1.70353973525433 0.687497214264005 803 212 0.0137385519065928 0.109033348252322 -PWY_5659_GDP_mannose_biosyn diagnosis CD 1.46226169434878 0.593058121839938 803 788 0.0139301720550687 0.109271574345925 -PWY_7234_inosine_5_phosphate_biosyn_III dysbiosisnonIBD Yes 1.46602924477965 0.594625460636894 803 690 0.0139439649446245 0.109271574345925 -PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I age age -0.9414150887106 0.3831051518462 803 792 0.0142528422238434 0.11099400881818 -PWY_7388_octanoyl_acyl_carrier_protein_biosyn dysbiosisUC Yes -1.86374293411196 0.759223004868045 803 535 0.0143842888335482 0.111321887494417 -PWY_5173_SP_of_acetyl_CoA_biosyn dysbiosisnonIBD Yes 2.32650939579295 0.956119707764535 803 335 0.0154433328631262 0.117334247580971 -FASYN_ELONG_PWY_fatty_acid_elongation__saturated dysbiosisUC Yes -1.84544984320372 0.759887272908051 803 532 0.0154561944772198 0.117334247580971 -PWY_7199_pyrimidine_dns_salvage dysbiosisUC Yes -1.50373591511822 0.619729706983198 803 694 0.0155142651541349 0.117334247580971 -PWY_5173_SP_of_acetyl_CoA_biosyn antibiotics Yes 1.62907732469542 0.670469296435198 803 335 0.0155918834237137 0.117334247580971 -PWY0_1296_purine_rns_deg age age -1.04055533854071 0.429332410228001 803 793 0.0156320105123926 0.117334247580971 -PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn antibiotics Yes -0.504217808838281 0.209315708065049 803 761 0.0162742068270342 0.121423123990926 -PWY_7219_adenosine_rnt_de_novo_biosyn dysbiosisUC Yes 0.245427644862995 0.102677510112845 803 803 0.0171142853593283 0.126930949748352 -PWY_5989_stearate_biosyn_II age age -2.44389560443087 1.0258348283489 803 575 0.0174887604580398 0.12793288991053 -PWY0_862_dodec_5_enoate_biosyn dysbiosisUC Yes -1.81432081761082 0.761760366980329 803 546 0.0175451452374195 0.12793288991053 -PANTO_PWY_phosphopantothenate_biosyn_I age age -0.59537691895859 0.250259451532095 803 798 0.0176403734573441 0.12793288991053 -PWY_6901_SP_of_glucose__xylose_deg age age -1.8699327759532 0.785907451070399 803 436 0.0176600779009721 0.12793288991053 -PWY_7220_adenosine_dnt_de_novo_biosyn_II age age -1.18416390385024 0.501238037103492 803 783 0.0184415249680763 0.131877196371536 -PWY_7222_guanosine_dnt_de_novo_biosyn_II age age -1.18416390385024 0.501238037103492 803 783 0.0184415249680763 0.131877196371536 -PWY66_400_glycolysis_VI dysbiosisCD Yes -0.440080553119025 0.186405010504921 803 789 0.0185220781420696 0.131877196371536 -PWY_1042_glycolysis_IV dysbiosisnonIBD Yes -0.327024020464739 0.139637398923078 803 803 0.0194787090298499 0.137853776595464 -PWY_7208_SP_of_pyrimidine_nucleobases_salvage dysbiosisUC Yes 0.552107369551107 0.235948814510189 803 794 0.0195827595966269 0.137853776595464 -FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation age age -2.57208833614667 1.10517084832061 803 539 0.0202855516302983 0.141297942859854 -PWY_7242_D_fructuronate_deg diagnosis CD -1.3980085157593 0.60093524876142 803 773 0.0202988216468008 0.141297942859854 -ANAGLYCOLYSIS_PWY_glycolysis_III diagnosis UC -0.541959792072256 0.234422333017812 803 801 0.021089974974617 0.145396731239547 -PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II age age -1.08953029197237 0.471387347039083 803 783 0.0211210339922616 0.145396731239547 -PWY_2942_L_lysine_biosyn_III dysbiosisCD Yes -0.200059349172418 0.087034140130862 803 802 0.0218365928821871 0.149496674347281 -PWY_2941_L_lysine_biosyn_II diagnosis UC -2.29737669310202 1.00330355750649 803 454 0.0223935537003995 0.152434718646547 -ANAGLYCOLYSIS_PWY_glycolysis_III dysbiosisCD Yes -0.221580406806395 0.0968864841344416 803 801 0.0225104239413842 0.152434718646547 -DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I diagnosis CD -0.897762149648618 0.39326219868104 803 790 0.0227553404557966 0.153260293015798 -PWY_5154_L_arginine_biosyn_III diagnosis UC 2.73027451494726 1.1975349112771 803 475 0.0229400100927613 0.153673400943982 -PWY_5177_glutaryl_CoA_deg dysbiosisCD Yes -0.835470560887026 0.367066206454403 803 753 0.0231654099316293 0.154353480079198 -ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn diagnosis UC -0.830122867508703 0.366039122282495 803 797 0.0236600791848168 0.156005640308873 -P42_PWY_incomplete_reductive_TCA_cyc dysbiosisUC Yes -1.34020526052796 0.590964697829162 803 636 0.0236671684976644 0.156005640308873 -ANAEROFRUCAT_PWY_homolactic_fermentation age age -1.0978083576094 0.484890771425391 803 770 0.0238958535559513 0.156005640308873 -PWY_6901_SP_of_glucose__xylose_deg diagnosis UC -2.19719744446751 0.970348583523281 803 436 0.0239141872383585 0.156005640308873 -PWY_5989_stearate_biosyn_II dysbiosisUC Yes -1.64350194370299 0.729073224200398 803 575 0.0245130935721857 0.158528459025866 -ANAEROFRUCAT_PWY_homolactic_fermentation diagnosis CD -1.4276553251504 0.633753866099814 803 770 0.0246059423943171 0.158528459025866 -PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn diagnosis CD 3.40743008667169 1.51330251771969 803 504 0.0246826011645409 0.158528459025866 -PWY_621_sucrose_deg_III age age -1.60351611835591 0.713762431028364 803 741 0.024996426548692 0.159720756306001 -PWY_6609_adenine__adenosine_salvage_III dysbiosisUC Yes -0.543978870471204 0.242360014470234 803 792 0.0251292824945726 0.159750438715497 -PWY_5667_CDP_diacylglycerol_biosyn_I dysbiosisUC Yes -0.29541637601192 0.132381561270503 803 801 0.0259785560048291 0.163512820559052 -PWY0_1319_CDP_diacylglycerol_biosyn_II dysbiosisUC Yes -0.2954077766099 0.132382187345371 803 801 0.0259835782268799 0.163512820559052 -PWY_4041_beta_glutamyl_cyc dysbiosisCD Yes 1.5122050707407 0.67896155075936 803 247 0.0266336553822621 0.166508440829747 -PWY_6703_preQ0_biosyn diagnosis CD -1.67826013908949 0.755823999798905 803 771 0.0267268765376801 0.166508440829747 -CITRULBIO_PWY_L_citrulline_biosyn diagnosis CD 2.43837586632766 1.10253649936378 803 688 0.0273476080703596 0.168874359266683 -PWY_7208_SP_of_pyrimidine_nucleobases_salvage diagnosis UC 0.958692238319397 0.433603521845272 803 794 0.0273777051138603 0.168874359266683 -PWY_7388_octanoyl_acyl_carrier_protein_biosyn age age -2.4625501545818 1.11846016008044 803 535 0.0280711454526309 0.171628196010118 -PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II diagnosis CD -0.474082398939629 0.215419735004758 803 798 0.0280996404382537 0.171628196010118 -PWY_7187_pyrimidine_dnt_de_novo_biosyn_II dysbiosisCD Yes 0.8790175211288 0.399952756541716 803 647 0.0283102359491576 0.172070995086099 -PWY_6353_purine_nt_deg_II dysbiosisnonIBD Yes -1.72695178629372 0.786423730958322 803 432 0.0284554465619995 0.172114011729376 -PWY_5101_L_isoleucine_biosyn_II dysbiosisnonIBD Yes 1.47384304615579 0.673903700627913 803 574 0.0291198395439606 0.175281739477173 -COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn diagnosis CD -1.12215502434144 0.514115139342888 803 773 0.0294096848705575 0.175659409196463 -GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg diagnosis CD -1.65634684079506 0.759115024723411 803 755 0.0294645397448321 0.175659409196463 -PWY_6527_stachyose_deg dysbiosisCD Yes -0.650819792382779 0.30093790343197 803 766 0.0309264067619489 0.183496680120897 -PWY0_1298_SP_of_pyrimidine_dns_deg diagnosis UC -2.58660450589624 1.20375023816246 803 455 0.0320309744958461 0.188067234386109 -HISDEG_PWY_L_histidine_deg_I age age -2.93467537772331 1.36864781162428 803 582 0.0324038054606549 0.188067234386109 -GLYCOLYSIS_glycolysis_I dysbiosisUC Yes -0.490006142600401 0.228616972647953 803 791 0.0324499055308832 0.188067234386109 -PWY_7664_oleate_biosyn_IV age age -2.41113643971288 1.1255135952566 803 531 0.0325823558317502 0.188067234386109 -PWY_5690_TCA_cyc_II antibiotics Yes -1.06909335800202 0.49915635827539 803 363 0.0326023456078648 0.188067234386109 -PWY_6282_palmitoleate_biosyn_I age age -2.43622081611288 1.13731043733733 803 531 0.032595675560779 0.188067234386109 -PWY_7237_myo__chiro__scillo_inositol_deg dysbiosisnonIBD Yes 2.12164997231393 0.995001623363449 803 441 0.0333645778667636 0.191577253557546 -PWY_5723_Rubisco_shunt diagnosis CD 3.40280891302731 1.59811772630159 803 212 0.0340055318979734 0.193771802435918 -PWY_6123_inosine_5_phosphate_biosyn_I dysbiosisCD Yes -0.317445467097846 0.149471142774951 803 794 0.0340578047620112 0.193771802435918 -PWY_6609_adenine__adenosine_salvage_III dysbiosisCD Yes -0.380928184243369 0.17962396330186 803 792 0.034318406797813 0.194366976682159 -COA_PWY_1_coenzyme_A_biosyn_II dysbiosisCD Yes -0.228571834043813 0.107931687239718 803 800 0.0345687754448608 0.194899068797722 -ARGSYNBSUB_PWY_L_arginine_biosyn_II diagnosis UC 3.50795234478356 1.65827417321762 803 428 0.0347875895790105 0.195249264033545 -PWY_7237_myo__chiro__scillo_inositol_deg diagnosis UC 3.2231891561406 1.52548686925485 803 441 0.0349996189547771 0.195558409047768 -PWY_5686_UMP_biosyn diagnosis CD 0.464676305374308 0.220277620313914 803 802 0.0352759812018213 0.195710807897112 -PWYG_321_mycolate_biosyn antibiotics Yes -1.08912751408391 0.516314899615009 803 484 0.0353410367390451 0.195710807897112 -PWY_5913_TCA_cyc_VI dysbiosisUC Yes 2.20868062493257 1.05076607978298 803 146 0.0362931386534313 0.20009402992113 -FASYN_ELONG_PWY_fatty_acid_elongation__saturated age age -2.33381008533388 1.11629440951929 803 532 0.0369851497956642 0.202434826336315 -PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I diagnosis UC 1.08527747143909 0.51939232238205 803 792 0.0370426487999036 0.202434826336315 -COA_PWY_1_coenzyme_A_biosyn_II diagnosis UC -0.552008643319785 0.265292571185297 803 800 0.0378403186291681 0.20589099131853 -PWY_3841_folate_transformations_II dysbiosisnonIBD Yes 0.531302158177561 0.256106951658205 803 787 0.0384157502436009 0.208113151319681 -ANAGLYCOLYSIS_PWY_glycolysis_III age age -0.370037928738964 0.179099764935781 803 801 0.0392081416900967 0.21148634002537 -PWY66_409_SP_of_purine_nt_salvage dysbiosisUC Yes 1.37067094630079 0.667108172255097 803 290 0.0403407637981788 0.215100679934508 -ANAGLYCOLYSIS_PWY_glycolysis_III diagnosis CD -0.480787565148031 0.234093781516703 803 801 0.0403854905492756 0.215100679934508 -GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg dysbiosisUC Yes -0.842349169041311 0.410158702730016 803 757 0.0403961148512639 0.215100679934508 -GLYOXYLATE_BYPASS_glyoxylate_cyc dysbiosisnonIBD Yes 2.88591178616923 1.40535040393256 803 255 0.040726745761618 0.215385553400785 -GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg diagnosis CD -1.621347248222 0.791719008218697 803 745 0.0409673674527648 0.215385553400785 -GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisnonIBD Yes 1.38002326821618 0.67388505032519 803 706 0.0409681991621076 0.215385553400785 -PWY_5723_Rubisco_shunt dysbiosisnonIBD Yes 2.02279896859514 0.991324488518343 803 212 0.0421313074030373 0.220569785815901 -PWY_4041_beta_glutamyl_cyc dysbiosisnonIBD Yes 2.222095319289 1.09049964402993 803 247 0.04241141150372 0.221107191354122 -PWY66_400_glycolysis_VI antibiotics Yes -0.325184006564041 0.160905849143336 803 789 0.043688565137571 0.226400537765929 -SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I age age -1.20268390521143 0.595400682117846 803 767 0.0437901521682093 0.226400537765929 -P42_PWY_incomplete_reductive_TCA_cyc age age -1.64624342565721 0.815917638211378 803 636 0.0440372483575055 0.226737237410958 -GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisUC Yes 1.23248893470933 0.614463165033732 803 706 0.0452848518722276 0.231474943568693 -GLYOXYLATE_BYPASS_glyoxylate_cyc age age -3.26169519803585 1.62402619056093 803 255 0.0453289616619271 0.231474943568693 -PWY0_1296_purine_rns_deg diagnosis UC -1.11463610845491 0.558594203215076 803 793 0.0464052805082405 0.234835308972683 -PWY_4242_pantothenate__coenzyme_A_biosyn_III diagnosis CD 1.98558449756849 0.995683852413033 803 725 0.0465408278094516 0.234835308972683 -THRESYN_PWY_SP_of_L_threonine_biosyn dysbiosisCD Yes 0.23288191867416 0.116786305282758 803 796 0.0465524248124019 0.234835308972683 -PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I dysbiosisCD Yes -0.598543905947332 0.301090594572384 803 765 0.0472364596679049 0.237325115912135 -PWY_7383_anaerobic_energy_metabolism diagnosis CD 2.42771434493264 1.22381325073863 803 698 0.0477338607198607 0.237567805483478 -PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I dysbiosisUC Yes -0.862193753797441 0.434715082489302 803 765 0.0477451035527287 0.237567805483478 -PWY_6901_SP_of_glucose__xylose_deg dysbiosisCD Yes 0.812338667337047 0.409702315722133 803 436 0.0478567569633652 0.237567805483478 -PWY_6700_queuosine_biosyn diagnosis UC 1.23227985590047 0.623231143512816 803 780 0.0484285264746147 0.239452158680039 -P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate dysbiosisUC Yes 1.75120320889801 0.88676367852566 803 283 0.0487326681982915 0.240003575395538 -PWY66_400_glycolysis_VI diagnosis UC 0.906460041922668 0.459826450250736 803 789 0.0491071268098653 0.240895590571229 -PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn diagnosis UC -2.93224242858277 1.4927105175364 803 504 0.0499189911645435 0.243306835372029 -PWY_6121_5_aminoimidazole_rnt_biosyn_I diagnosis UC 0.589531603311326 0.30022284416941 803 799 0.0499892053412837 0.243306835372029 -PWY66_409_SP_of_purine_nt_salvage diagnosis UC -2.11713981524635 1.07945546258629 803 290 0.0503003505032321 0.243868625396993 -PWY_7242_D_fructuronate_deg dysbiosisUC Yes 0.655252129434378 0.334960663781829 803 773 0.0508609833743255 0.244290439161783 -PWY_4981_L_proline_biosyn_II dysbiosisnonIBD Yes 1.53031871286915 0.782574386641866 803 678 0.0509516668633515 0.244290439161783 -PWY_5188_tetrapyrrole_biosyn_I dysbiosisCD Yes 0.713044797873293 0.364946236413597 803 731 0.0511427303653103 0.244290439161783 -P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate age age -2.42632408421033 1.24287730948993 803 283 0.0513676525364263 0.244290439161783 -PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II age age -0.959536927258179 0.491559171971616 803 769 0.0513561822889642 0.244290439161783 -PWY_6151_S_adenosyl_L_methionine_cyc_I diagnosis CD -0.7595556305137 0.389738295552138 803 791 0.0517310470026779 0.245083211275044 -PENTOSE_P_PWY_pentose_phosphate_pwy dysbiosisUC Yes -1.19120413784332 0.613443254340229 803 613 0.0525924200814272 0.248123996175261 -RIBOSYN2_PWY_flavin_biosyn_I age age -1.6650337470461 0.857974538154669 803 478 0.0527711548847866 0.248123996175261 -PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg diagnosis CD -1.59924783167854 0.825485293988914 803 757 0.0531298001322517 0.248346722318496 -PWY_7196_SP_of_pyrimidine_rns_salvage dysbiosisnonIBD Yes -1.37929616490298 0.712125565706007 803 411 0.0532171547825349 0.248346722318496 -PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn antibiotics Yes 0.632329210377961 0.329119282252539 803 604 0.0551325041445926 0.256325000612546 -PWY_5188_tetrapyrrole_biosyn_I antibiotics Yes 0.608325240927957 0.317156548771615 803 731 0.0555346104426405 0.256855672539302 -PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I age age -2.20562457330144 1.15048315106245 803 557 0.0556589338568312 0.256855672539302 -PWY_5686_UMP_biosyn age age -0.323841936953824 0.169681342644488 803 802 0.056754958033242 0.26094715021926 -PWY0_1586_peptidoglycan_maturation dysbiosisCD Yes 0.655484446141231 0.345081418173373 803 773 0.0579329236030955 0.26538390738771 -PWY0_1296_purine_rns_deg diagnosis CD -1.06563284559584 0.562314914050435 803 793 0.0585169610648057 0.266980047430158 -PWY_6897_thiamin_salvage_II diagnosis CD -1.9387756308283 1.02407151448341 803 589 0.058767346465719 0.266980047430158 -PWY_6317_galactose_deg_I dysbiosisCD Yes -0.536679698011158 0.283654032199183 803 765 0.0589241677715036 0.266980047430158 -PWY_6527_stachyose_deg age age -1.05876261723682 0.561629912046444 803 766 0.05984586808715 0.269953751035366 -PWY66_400_glycolysis_VI dysbiosisUC Yes -0.489549250108025 0.259902263079233 803 789 0.0600612252178682 0.269953751035366 -PWY_7663_gondoate_biosyn diagnosis CD 1.00188936609833 0.532262007691737 803 792 0.0602304516756275 0.269953751035366 -GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff dysbiosisUC Yes 1.46293962624556 0.778852006253028 803 412 0.0608068502155156 0.271560341822697 -PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I dysbiosisCD Yes -0.135553327443761 0.0723897009488865 803 799 0.0615711315536949 0.273991535413942 -PWY_6168_flavin_biosyn_III diagnosis UC 1.11446874131641 0.599228898798457 803 760 0.0633531260072637 0.279608363616487 -PWY_6353_purine_nt_deg_II diagnosis UC -2.38131098234413 1.2809481706089 803 432 0.0634856634199247 0.279608363616487 -PWY_5100_pyruvate_fermentation_to_acetate__lactate_II age age 1.01262945848666 0.544789982158124 803 778 0.0635065544971636 0.279608363616487 -PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn diagnosis UC 1.85006562458881 0.997191776928872 803 469 0.0640100996982572 0.280718977899274 -PWY_3001_SP_of_L_isoleucine_biosyn_I age age -0.566502489454283 0.305586392297805 803 782 0.0642093970315353 0.280718977899274 -ARGSYNBSUB_PWY_L_arginine_biosyn_II diagnosis CD 3.06873598468393 1.65663172498891 803 428 0.064438929623412 0.280737434653047 -GLUCONEO_PWY_gluconeogenesis_I dysbiosisnonIBD Yes 1.89725686502414 1.02576106608156 803 457 0.065023961357847 0.281702194711769 -PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III diagnosis UC 2.19465602630698 1.18781768769473 803 512 0.0651125458081778 0.281702194711769 -DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II diagnosis UC 1.67286560795308 0.906557832770958 803 614 0.0654446170535494 0.282159144805268 -OANTIGEN_PWY_O_antigen_building_blocks_biosyn dysbiosisCD Yes 0.76060861348149 0.415776994122622 803 445 0.067825558300445 0.291416019456395 -PWY0_1261_anhydromuropeptides_recycling age age -1.90840722917121 1.04614427730404 803 273 0.0686627883420365 0.293999430495455 -PWY_6385_peptidoglycan_biosyn_III diagnosis UC -0.460533822105636 0.253081222011558 803 797 0.0692550557424601 0.295519861147621 -PWY_1042_glycolysis_IV dysbiosisUC Yes 0.226231414636041 0.124434589345902 803 803 0.0695044934369184 0.295572009632766 -PWY_1042_glycolysis_IV diagnosis UC -0.409275943550496 0.225727083449703 803 803 0.0702622045829119 0.297777914660912 -ARO_PWY_chorismate_biosyn_I age age -0.764431622977923 0.422743128243749 803 775 0.07101960347977 0.299967545545062 -PWY_7237_myo__chiro__scillo_inositol_deg dysbiosisCD Yes 1.16342479870943 0.644214888799127 803 441 0.0713983485989922 0.300224245758039 -PWY_5973_cis_vaccenate_biosyn dysbiosisCD Yes -0.365549635679261 0.202544450682886 803 787 0.071562280088393 0.300224245758039 -NAGLIPASYN_PWY_lipid_IVA_biosyn diagnosis UC 1.92118545410533 1.06615039113362 803 601 0.072034396493607 0.30119079876186 -PWY_6124_inosine_5_phosphate_biosyn_II dysbiosisCD Yes -0.33358205498735 0.185686897889289 803 792 0.0728746321915124 0.303684922109112 -PWY_5659_GDP_mannose_biosyn dysbiosisUC Yes 0.568223119542943 0.316616695686498 803 788 0.0731627668567623 0.303869358345086 -PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine diagnosis CD -1.96773594959284 1.0981353656847 803 597 0.0736081353565186 0.304703444033961 -PWY_5173_SP_of_acetyl_CoA_biosyn diagnosis CD 2.62548114864388 1.46905912355834 803 335 0.0747394492081373 0.30693739126771 -GLYOXYLATE_BYPASS_glyoxylate_cyc dysbiosisCD Yes 1.50904099677193 0.844865723451526 803 255 0.0748990048568761 0.30693739126771 -PWY_7184_pyrimidine_dnt_de_novo_biosyn_I age age -0.956205823811959 0.536352078764235 803 747 0.0750792050491562 0.30693739126771 -PWY_7111_pyruvate_fermentation_to_isobutanol dysbiosisnonIBD Yes 0.329798579836351 0.185130803466364 803 801 0.0752997082296032 0.30693739126771 -DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I dysbiosisUC Yes -0.382516308721693 0.214781967918755 803 790 0.0753794877431135 0.30693739126771 -PWY_7187_pyrimidine_dnt_de_novo_biosyn_II diagnosis CD -1.73979248715838 0.97937635334964 803 647 0.0761235348587563 0.307912497862552 -PWY0_1261_anhydromuropeptides_recycling dysbiosisUC Yes 1.4270893904484 0.803569864261887 803 273 0.0762991603380888 0.307912497862552 -CALVIN_PWY_Calvin_Benson_Bassham_cyc dysbiosisUC Yes 0.312886785985708 0.17627563302729 803 797 0.0763603225036345 0.307912497862552 -PWY0_1261_anhydromuropeptides_recycling diagnosis CD 2.45233585278165 1.38500422775243 803 273 0.0771784325282659 0.310207506226514 -OANTIGEN_PWY_O_antigen_building_blocks_biosyn diagnosis UC -1.81550556740347 1.02682632361139 803 445 0.0775409659797865 0.310489761704659 -PWY_7199_pyrimidine_dns_salvage age age -1.51525992702873 0.858090157130069 803 694 0.0778823288299676 0.310489761704659 -PYRIDNUCSYN_PWY_NAD_biosyn_I antibiotics Yes -0.558892488183254 0.316618757423589 803 707 0.0779962242484415 0.310489761704659 -P441_PWY_SP_of_N_acetylneuraminate_deg diagnosis CD -2.50882180400943 1.42350713000187 803 433 0.0784670666674952 0.311157501700873 -RIBOSYN2_PWY_flavin_biosyn_I diagnosis CD 1.97612409272249 1.12183006305576 803 478 0.0786634133513442 0.311157501700873 -PWY_6609_adenine__adenosine_salvage_III age age -0.594535836858721 0.338372108758996 803 792 0.0793719745055922 0.312966709601164 -PWY_6969_TCA_cyc_V dysbiosisnonIBD Yes 1.34427923746728 0.766454503068841 803 403 0.0799733541596402 0.313249151774536 -PWY_7208_SP_of_pyrimidine_nucleobases_salvage diagnosis CD 0.759811894587016 0.433552856928598 803 794 0.080146624860526 0.313249151774536 -PWY66_422_D_galactose_deg_V age age -0.775990685901685 0.442859780205041 803 785 0.0801978165458082 0.313249151774536 -COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I diagnosis CD -1.6004100837683 0.917396476927417 803 578 0.0815387177268015 0.317133050807595 -UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I diagnosis CD -2.124367761202 1.21829333010957 803 503 0.0817012113236259 0.317133050807595 -PWY_5686_UMP_biosyn dysbiosisUC Yes 0.207794214173753 0.119417380353628 803 802 0.0823120036818555 0.318435535584143 -PWY_5695_urate_biosyn_inosine_5_phosphate_deg antibiotics Yes 0.173602892619917 0.0998448924951519 803 800 0.0825478956610579 0.318435535584143 -PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I diagnosis CD 0.900316554130807 0.519819531566768 803 792 0.083743097758665 0.32204907347931 -PWY_5083_NAD_NADH_phosphorylation__dephosphorylation dysbiosisnonIBD Yes 1.42704969408651 0.825067485833527 803 431 0.0843458595863819 0.322807563267247 -OANTIGEN_PWY_O_antigen_building_blocks_biosyn diagnosis CD -1.8664013081711 1.08063413253298 803 445 0.0846422269027023 0.322807563267247 -COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I age age -1.21503774838049 0.703731771453098 803 578 0.0847175547258346 0.322807563267247 -FUCCAT_PWY_fucose_deg age age 2.06729711947785 1.19975943864237 803 268 0.0854582930938293 0.324637296325949 -PWY_7184_pyrimidine_dnt_de_novo_biosyn_I diagnosis UC 1.21107095137174 0.703848546014245 803 747 0.085784610802381 0.324886398357954 -PWY_4981_L_proline_biosyn_II antibiotics Yes -0.745606351546944 0.434224182691919 803 678 0.0864357926086272 0.326357257645926 -GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg age age -2.08228449099627 1.21291913998513 803 300 0.0867509088303248 0.326357257645926 -PWY_5676_acetyl_CoA_fermentation_to_butanoate_II diagnosis UC 3.12555056290052 1.82455026945597 803 459 0.0872789879503227 0.326357257645926 -PWY_6901_SP_of_glucose__xylose_deg dysbiosisUC Yes 1.03379121791838 0.604049677632719 803 436 0.0875247959053426 0.326357257645926 -TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA dysbiosisnonIBD Yes 1.64097048177466 0.957723269521512 803 159 0.0876340617089333 0.326357257645926 -PWY_7383_anaerobic_energy_metabolism age age -1.60707051090619 0.939987889379002 803 698 0.0878351952013644 0.326357257645926 -PWY_6151_S_adenosyl_L_methionine_cyc_I dysbiosisnonIBD Yes 0.406997969343197 0.238284721251134 803 791 0.0880991807559045 0.326357257645926 -PWY_621_sucrose_deg_III diagnosis UC 1.54876930943429 0.907778807429431 803 741 0.0884568756447824 0.326357257645926 -X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn age age -0.693517028038394 0.406584439511761 803 779 0.0885302994256205 0.326357257645926 -PWY0_1479_tRNA_processing dysbiosisCD Yes 0.999588799945606 0.586453420219723 803 414 0.088959548644006 0.326972264337556 -PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn age age -0.853708864053021 0.503031152543641 803 742 0.0901436948630488 0.330350128821643 -PWY_7242_D_fructuronate_deg diagnosis UC -1.00982094038986 0.595548895268925 803 773 0.0904292381673472 0.330424723626143 -GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff age age -1.90560082680621 1.12912236290389 803 412 0.0919766262132136 0.334990407389412 -GLUCONEO_PWY_gluconeogenesis_I dysbiosisUC Yes 2.6090227623146 1.54617240659612 803 457 0.0922164604611304 0.334990407389412 -PWY_6608_guanosine_nt_deg_III dysbiosisUC Yes -1.01351593206196 0.602886961936739 803 686 0.0932186358219806 0.33764657044822 -PWY_5690_TCA_cyc_II dysbiosisnonIBD Yes -1.40241976297713 0.835936753302692 803 363 0.0939219125443523 0.338191583210892 -PWY_5971_palmitate_biosyn_II dysbiosisCD Yes 0.964493828308154 0.575051930172053 803 143 0.0941406775871886 0.338191583210892 -GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg age age -0.968159416605148 0.57761201328869 803 757 0.0941833702842532 0.338191583210892 -TRNA_CHARGING_PWY_tRNA_charging dysbiosisCD Yes -0.666033286264013 0.397755656766465 803 703 0.0945125090581592 0.338398236455363 -PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II antibiotics Yes -0.174112528054147 0.104244083354618 803 794 0.0953447955358671 0.339506466366225 -GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg diagnosis CD -1.24824887054381 0.748744566346301 803 757 0.0959637484151843 0.339506466366225 -PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn age age -2.13434201614529 1.28036989518564 803 504 0.0960090208698011 0.339506466366225 -PWYG_321_mycolate_biosyn age age -1.97111538554106 1.18328794029956 803 484 0.096300768870565 0.339506466366225 -PWY_6270_isoprene_biosyn_I antibiotics Yes -0.769577681824977 0.461934790752576 803 219 0.0963447008160771 0.339506466366225 -FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation dysbiosisCD Yes 0.927412705907995 0.557488040437142 803 539 0.0967321696910786 0.339506466366225 -PWY_3841_folate_transformations_II age age -0.541897409718 0.325788532107762 803 787 0.0967174995935534 0.339506466366225 -PWY_2941_L_lysine_biosyn_II antibiotics Yes -0.611227856162487 0.367998513463605 803 454 0.0972682190707576 0.339506466366225 -PWY_7111_pyruvate_fermentation_to_isobutanol diagnosis UC 0.503415418968356 0.303159076569292 803 801 0.0972743246330194 0.339506466366225 -PWY_5676_acetyl_CoA_fermentation_to_butanoate_II dysbiosisCD Yes -1.07243974462915 0.646928175582696 803 459 0.0979525643643461 0.340918701670322 -PANTO_PWY_phosphopantothenate_biosyn_I dysbiosisCD Yes -0.216722947184885 0.131015834586752 803 798 0.0985662601195206 0.341904680861633 -PWY_5484_glycolysis_II antibiotics Yes -0.242782834273411 0.146864568901974 803 791 0.0987846589969404 0.341904680861633 -PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn diagnosis UC 1.08164535905345 0.656363700124013 803 742 0.0998417469938551 0.343422948277519 -PWY66_400_glycolysis_VI age age -0.583662539491734 0.354145737896529 803 789 0.0998124525692122 0.343422948277519 -NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I antibiotics Yes -0.151375091037384 0.0919143563894856 803 799 0.100050184771059 0.343422948277519 -PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II diagnosis UC -0.351674548508771 0.214221051784241 803 798 0.101139614302612 0.345100251466576 -PWY_4041_beta_glutamyl_cyc diagnosis CD 2.61914150153845 1.59438465004362 803 247 0.101430587931656 0.345100251466576 -PWY0_1586_peptidoglycan_maturation diagnosis CD -1.42693502006249 0.870143994227192 803 773 0.101505112687979 0.345100251466576 -DAPLYSINESYN_PWY_L_lysine_biosyn_I age age -1.23453308137104 0.753283272534021 803 595 0.101729576784395 0.345100251466576 -PWY_6163_chorismate_biosyn_from_3_dehydroquinate dysbiosisCD Yes -0.361806624165032 0.220900014361624 803 787 0.10192366977504 0.345100251466576 -ANAGLYCOLYSIS_PWY_glycolysis_III dysbiosisUC Yes -0.21589755761881 0.132206114078401 803 801 0.102937300509607 0.34758774101618 -COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn dysbiosisnonIBD Yes -0.51564262043445 0.316390801913602 803 773 0.103627608642396 0.348972973968717 -PWY_6527_stachyose_deg dysbiosisUC Yes -0.646163882517761 0.396902335932541 803 766 0.103997003989079 0.349272956793511 -UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I diagnosis UC -1.88212750660719 1.15804166404064 803 503 0.104612118696696 0.350394354559363 -GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg antibiotics Yes -0.428938358635707 0.264288326330524 803 755 0.10506676682078 0.350973703642606 -PWY_7197_pyrimidine_dnt_phosphorylation antibiotics Yes -0.430165075096865 0.265371926254729 803 751 0.105497535821038 0.351470400088271 -PWY_6168_flavin_biosyn_III antibiotics Yes -0.305355532030644 0.188598984695832 803 760 0.105909266760232 0.351901190355331 -VALSYN_PWY_L_valine_biosyn diagnosis UC 0.498606397930255 0.308343063773422 803 802 0.106343691941014 0.352404894038573 -PWY_5971_palmitate_biosyn_II antibiotics Yes -0.743470999251454 0.460577030581204 803 143 0.107129526678082 0.353572254462722 -PWY_1042_glycolysis_IV age age 0.28166193342111 0.174852342719584 803 803 0.107687791404009 0.353572254462722 -P441_PWY_SP_of_N_acetylneuraminate_deg diagnosis UC -2.29045847875187 1.42235138061151 803 433 0.107810055281891 0.353572254462722 -PWY_6700_queuosine_biosyn dysbiosisUC Yes -0.51543722690347 0.320107699389527 803 780 0.107831024635501 0.353572254462722 -TCA_TCA_cyc_I diagnosis UC -1.8863529684252 1.1733784801929 803 412 0.10845680879562 0.354475072877169 -ARO_PWY_chorismate_biosyn_I diagnosis CD -0.87862410063207 0.54697042023368 803 775 0.108675343370047 0.354475072877169 -PWY_6168_flavin_biosyn_III diagnosis CD 0.966051626165718 0.602115183895497 803 760 0.109097693823321 0.354923567895191 -PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II diagnosis UC 1.05690197578752 0.661761898739343 803 769 0.110719927091897 0.358329945861048 -PWY_6969_TCA_cyc_V age age -1.53537642847863 0.96105435154961 803 403 0.11067385432625 0.358329945861048 -PWY_7456_mannan_deg diagnosis UC -2.10301881491114 1.3215212927527 803 210 0.112254534677327 0.362355311419558 -COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I antibiotics Yes 0.5028727810807 0.316640455491174 803 578 0.112734820368232 0.362734581669941 -PWY_5173_SP_of_acetyl_CoA_biosyn age age -1.92584315898513 1.2120712034901 803 335 0.112954267807333 0.362734581669941 -NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I diagnosis UC -0.420020813953451 0.264862564006094 803 799 0.113260704994589 0.362783646332282 -PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I dysbiosisCD Yes -0.410488202216856 0.26035819186242 803 762 0.115358701632884 0.368397749812518 -PWY0_1479_tRNA_processing antibiotics Yes 0.740193433161989 0.46975347817083 803 414 0.115770699698566 0.368397749812518 -PWY_4242_pantothenate__coenzyme_A_biosyn_III diagnosis UC 1.57019564747712 0.997405367415064 803 725 0.115900415671354 0.368397749812518 -PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn dysbiosisCD Yes -0.94874905787503 0.604173065069562 803 504 0.116833376530936 0.370418287932688 -PWY_7234_inosine_5_phosphate_biosyn_III antibiotics Yes -0.529704792503623 0.33794179026933 803 690 0.117503704112285 0.371598008436312 -PWY_5104_L_isoleucine_biosyn_IV age age -2.06303168608165 1.31874029308556 803 475 0.118223638206808 0.372928235963754 -ARO_PWY_chorismate_biosyn_I dysbiosisnonIBD Yes -0.52683060167112 0.337085521120271 803 775 0.118554978342405 0.373029048016759 -UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I dysbiosisnonIBD Yes 1.09940510590462 0.704911854891065 803 503 0.11935482260595 0.373261981022157 -PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I age age -0.216112842365724 0.138602693665171 803 799 0.119420944339399 0.373261981022157 -DAPLYSINESYN_PWY_L_lysine_biosyn_I dysbiosisCD Yes 0.592623095992324 0.380170765959117 803 595 0.119527713023949 0.373261981022157 -PWY_7221_guanosine_rnt_de_novo_biosyn dysbiosisnonIBD Yes 0.187352048081567 0.121500512622773 803 802 0.123554933419412 0.383938560134256 -THRESYN_PWY_SP_of_L_threonine_biosyn diagnosis CD 0.442166654844914 0.286757560162382 803 796 0.123562891343368 0.383938560134256 -P161_PWY_acetylene_deg diagnosis UC -1.91926183508961 1.2469191484419 803 537 0.124242111077366 0.384493000576057 -PWY_5177_glutaryl_CoA_deg age age 0.998175615146832 0.648944735265328 803 753 0.124497347379057 0.384493000576057 -PWY_7199_pyrimidine_dns_salvage dysbiosisnonIBD Yes -1.04208259219206 0.677809061709392 803 694 0.124667072417919 0.384493000576057 -TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA diagnosis CD 2.16192514722154 1.40716717006455 803 159 0.12546512140991 0.385998867349995 -PWY_6151_S_adenosyl_L_methionine_cyc_I antibiotics Yes 0.207573349384651 0.135923633817765 803 791 0.12720577889041 0.389656935121065 -PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine antibiotics Yes 0.589139817480333 0.385856094712178 803 597 0.12727959277229 0.389656935121065 -PWY_5083_NAD_NADH_phosphorylation__dephosphorylation diagnosis CD 2.10443311384376 1.3796582684643 803 431 0.127839730464529 0.390412510193145 -PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II diagnosis CD 1.00739099552675 0.661487491297318 803 769 0.128256825725498 0.390728618224867 -PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn antibiotics Yes -0.348389861298011 0.228973122208608 803 742 0.12860540033314 0.390834948329494 -PWY66_422_D_galactose_deg_V diagnosis CD -0.883127568962191 0.581887543130231 803 785 0.129568794352456 0.391839350368757 -PWY_7220_adenosine_dnt_de_novo_biosyn_II dysbiosisCD Yes 0.397900923701284 0.262387266052722 803 783 0.129879335234588 0.391839350368757 -PWY_7222_guanosine_dnt_de_novo_biosyn_II dysbiosisCD Yes 0.397900923701284 0.262387266052722 803 783 0.129879335234588 0.391839350368757 -PWY0_1297_SP_of_purine_dns_deg antibiotics Yes 0.601306011361174 0.397213805586832 803 610 0.130554340033469 0.392924414690102 -VALSYN_PWY_L_valine_biosyn dysbiosisCD Yes 0.192058832536078 0.127010626253832 803 802 0.130973489190069 0.39323606633934 -PWY_841_SP_of_purine_nt_de_novo_biosyn_I age age 1.35114335017897 0.896949227726455 803 651 0.13245261658511 0.396356589175336 -PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn dysbiosisCD Yes 0.584176627525158 0.388318696181487 803 604 0.13296928096801 0.396356589175336 -PWY_7184_pyrimidine_dnt_de_novo_biosyn_I antibiotics Yes -0.36691637104545 0.244316562497101 803 747 0.133625174618616 0.396356589175336 -PWY_5913_TCA_cyc_VI antibiotics Yes 1.08115333179615 0.719372379816418 803 146 0.133792715051449 0.396356589175336 -VALSYN_PWY_L_valine_biosyn age age 0.365086610787 0.243211768741588 803 802 0.133804974593383 0.396356589175336 -GLYCOLYSIS_glycolysis_I antibiotics Yes -0.219403436208624 0.146204517436593 803 791 0.133921447867429 0.396356589175336 -PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn diagnosis CD 1.49003681479534 0.994720565027924 803 469 0.134633707773578 0.397520378876489 -PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn dysbiosisCD Yes 0.70877142413568 0.474292710555759 803 281 0.135596285390363 0.399340834530824 -PWY_6317_galactose_deg_I age age -0.791712683706314 0.530252784367084 803 765 0.135891263114823 0.399340834530824 -PWY_6936_seleno_amino_acid_biosyn dysbiosisCD Yes 0.855682011270535 0.575991409600122 803 472 0.137868134680436 0.402793970472389 -GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg dysbiosisUC Yes 0.627353032447961 0.42240308853657 803 755 0.13796689114692 0.402793970472389 -PWY_6270_isoprene_biosyn_I age age -1.45556406721891 0.979827911763755 803 219 0.138036135948403 0.402793970472389 -PWY_6897_thiamin_salvage_II antibiotics Yes 0.522856913284624 0.354223032832631 803 589 0.140402120526297 0.408740752747117 -PWY_6897_thiamin_salvage_II dysbiosisCD Yes 0.612169513467315 0.416909133281983 803 589 0.142484229875415 0.413835315675448 -PWY_7197_pyrimidine_dnt_phosphorylation dysbiosisnonIBD Yes -0.679921835990639 0.464209679543316 803 751 0.143482522089173 0.415765633774673 -PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn diagnosis UC 1.63547929823681 1.12448392572416 803 281 0.14634410746397 0.42296722779867 -COA_PWY_coenzyme_A_biosyn_I dysbiosisCD Yes -0.404047342947086 0.278042947393071 803 774 0.146646743506441 0.42296722779867 -PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I diagnosis UC -0.259954406164923 0.179269536229273 803 799 0.147510995732847 0.423499310329787 -PWY_7196_SP_of_pyrimidine_rns_salvage antibiotics Yes -0.639270865751632 0.440786177206853 803 411 0.14748386404118 0.423499310329787 -PWY_3841_folate_transformations_II dysbiosisCD Yes -0.245689085525521 0.169753422157978 803 787 0.148278110283889 0.424723046928105 -MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn diagnosis CD -1.90311587338955 1.32042755225987 803 375 0.149985011002058 0.426292091063941 -GLYCOLYSIS_glycolysis_I dysbiosisnonIBD Yes 0.366591867104128 0.254389329580473 803 791 0.150040229918209 0.426292091063941 -PWY_7197_pyrimidine_dnt_phosphorylation age age -0.839737226332085 0.582779014494515 803 751 0.150081868088875 0.426292091063941 -PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisnonIBD Yes -0.877242548729066 0.609023290320239 803 469 0.15023398230007 0.426292091063941 -PWY_6124_inosine_5_phosphate_biosyn_II antibiotics Yes 0.227591497643598 0.158220560046976 803 792 0.150780548902099 0.426292091063941 -PWY_6901_SP_of_glucose__xylose_deg antibiotics Yes -0.531471040083439 0.369793289547173 803 436 0.15118631587486 0.426292091063941 -PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I dysbiosisCD Yes -0.100641821948175 0.0700412699792895 803 799 0.151220789927979 0.426292091063941 -PWY_7663_gondoate_biosyn dysbiosisCD Yes -0.277357355013621 0.193281953117926 803 792 0.151762669415503 0.426853918942927 -DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II dysbiosisCD Yes 0.53184120114828 0.371245736577134 803 614 0.152451991695787 0.427826985704844 -PWY_5154_L_arginine_biosyn_III dysbiosisnonIBD Yes 1.05493570027338 0.737180652837648 803 475 0.15290505261781 0.428134147329868 -COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I diagnosis UC -1.28454319575456 0.899820986168652 803 578 0.153896793917499 0.429061907702314 -DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I diagnosis UC -0.560594370585188 0.392726867059152 803 790 0.153925098509578 0.429061907702314 -PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II diagnosis UC 0.909387658076526 0.64021995062904 803 783 0.155953314167986 0.433745155029711 -DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II antibiotics Yes -0.454077086483101 0.320325533715443 803 614 0.156796593100152 0.435119276175478 -PWY_6608_guanosine_nt_deg_III dysbiosisCD Yes -0.60999333420491 0.431053184533098 803 686 0.157506915926106 0.436119149430951 -PWY_7663_gondoate_biosyn diagnosis UC 0.743310216525084 0.529000480446167 803 792 0.160454079461839 0.441702162647206 -X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn antibiotics Yes -0.257962162058701 0.183667282747591 803 779 0.160636646204789 0.441702162647206 -PWY_6122_5_aminoimidazole_rnt_biosyn_II age age -0.345241388125219 0.246175801040326 803 799 0.16125920079849 0.441702162647206 -PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn age age -0.345241388125219 0.246175801040326 803 799 0.16125920079849 0.441702162647206 -PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg dysbiosisUC Yes 0.65153270989497 0.464617086885998 803 757 0.161295733550946 0.441702162647206 -FUCCAT_PWY_fucose_deg dysbiosisnonIBD Yes 1.34611083074519 0.961545415599846 803 268 0.16211815168162 0.442665104155296 -PWY_5695_urate_biosyn_inosine_5_phosphate_deg age age 0.307605623906298 0.219915511396543 803 800 0.162357907382801 0.442665104155296 -PWY_5484_glycolysis_II dysbiosisnonIBD Yes 0.35616550834983 0.255311019091812 803 791 0.163477263896188 0.444743822739411 -PWY_5100_pyruvate_fermentation_to_acetate__lactate_II dysbiosisCD Yes 0.400469728683177 0.287445356968339 803 778 0.164026740099032 0.445140567669529 -PWY_6385_peptidoglycan_biosyn_III dysbiosisUC Yes -0.190774779858897 0.137033852366825 803 797 0.164337609251993 0.445140567669529 -PWY_4242_pantothenate__coenzyme_A_biosyn_III dysbiosisCD Yes -0.56034882812038 0.403241186347073 803 725 0.165113854562493 0.446273021225306 -PWY_5659_GDP_mannose_biosyn dysbiosisnonIBD Yes 0.49012067589423 0.353338246886413 803 788 0.165874321449978 0.447172035561123 -NAGLIPASYN_PWY_lipid_IVA_biosyn dysbiosisCD Yes 0.612460175088579 0.441805074026181 803 601 0.166164247564045 0.447172035561123 -GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg diagnosis UC -1.04108971059532 0.751887729921687 803 755 0.166630743481575 0.447461005125091 -PWY_6282_palmitoleate_biosyn_I dysbiosisCD Yes 0.790178873745326 0.572070956462449 803 531 0.167722729054923 0.447470104099659 -METSYN_PWY_L_homoserine__L_methionine_biosyn diagnosis CD -1.7452285227334 1.26459857870184 803 375 0.168041034933597 0.447470104099659 -PWY_7237_myo__chiro__scillo_inositol_deg diagnosis CD 2.10336266928693 1.52401737993935 803 441 0.168028155154077 0.447470104099659 -PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn diagnosis CD -1.29533582085216 0.939282866990791 803 604 0.168346378998401 0.447470104099659 -GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg dysbiosisUC Yes 0.606204639474184 0.439666740368319 803 745 0.168429758284703 0.447470104099659 -PWY_621_sucrose_deg_III dysbiosisUC Yes 0.684878022287588 0.498255128799986 803 741 0.16973521010085 0.4499788761397 -PWY_4981_L_proline_biosyn_II dysbiosisCD Yes 0.682701685204061 0.497892442555039 803 678 0.17078964209504 0.45085570773394 -PWY66_409_SP_of_purine_nt_salvage diagnosis CD -1.48224226196192 1.08087142145589 803 290 0.170775707618972 0.45085570773394 -PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I dysbiosisUC Yes -0.622684231241772 0.455194299445235 803 764 0.17179246779878 0.452544217499535 -PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I antibiotics Yes -0.35469030015905 0.259643451485644 803 765 0.172386825800062 0.453151866976534 -PWY_7560_methylerythritol_phosphate_pwy_II age age -1.37158836455768 1.00607998954298 803 226 0.173396813802272 0.454847221047644 -PWY_841_SP_of_purine_nt_de_novo_biosyn_I dysbiosisUC Yes 0.883686875233987 0.649775622087071 803 651 0.174301710409778 0.455479676181888 -PWY_5101_L_isoleucine_biosyn_II diagnosis CD 1.63857385320704 1.20493648874726 803 574 0.174369025312007 0.455479676181888 -PWY_621_sucrose_deg_III dysbiosisnonIBD Yes -0.758220577418326 0.559005836320995 803 741 0.175442833108007 0.45725156405991 -PWY_5097_L_lysine_biosyn_VI antibiotics Yes -0.116423620186864 0.0859485891064831 803 802 0.176015827400532 0.45725156405991 -PWY_5030_L_histidine_deg_III dysbiosisUC Yes -0.948458047381077 0.700357760442091 803 542 0.176148275079259 0.45725156405991 -DAPLYSINESYN_PWY_L_lysine_biosyn_I diagnosis UC 1.24547135958653 0.921792201663982 803 595 0.177125438035026 0.457863827602911 -PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I age age -0.521146639203789 0.385879562138667 803 783 0.177303602710797 0.457863827602911 -PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn dysbiosisUC Yes -0.740690467087571 0.549307357057125 803 604 0.17799538129944 0.457863827602911 -PWY_5973_cis_vaccenate_biosyn dysbiosisUC Yes 0.374462653147245 0.277811864988547 803 787 0.178151557235572 0.457863827602911 -ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn dysbiosisUC Yes -0.27094342989116 0.20104360668113 803 797 0.178221473826173 0.457863827602911 -X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn dysbiosisnonIBD Yes 0.430052610247156 0.320398808022602 803 779 0.179977797769367 0.461240298458173 -PWY_6969_TCA_cyc_V antibiotics Yes -0.633754996948892 0.472418877943381 803 403 0.180276103811501 0.461240298458173 -PWY_6121_5_aminoimidazole_rnt_biosyn_I age age -0.310914554203894 0.232425753660136 803 799 0.18145554579678 0.463306577997516 -PWY_6936_seleno_amino_acid_biosyn diagnosis CD -1.87595972706439 1.40882634493984 803 472 0.183459864921707 0.46746624067985 -PWY_6353_purine_nt_deg_II antibiotics Yes -0.607395499651133 0.456674136341406 803 432 0.183981398018136 0.467473718377322 -COA_PWY_coenzyme_A_biosyn_I age age -0.707805157394031 0.533302622984773 803 774 0.184896408156987 0.467473718377322 -HISDEG_PWY_L_histidine_deg_I antibiotics Yes -0.780084215991707 0.587805226600379 803 582 0.184959668188048 0.467473718377322 -PWY66_399_gluconeogenesis_III age age -1.37511341180679 1.03718393903809 803 670 0.185402368435967 0.467473718377322 -ARGSYN_PWY_L_arginine_biosyn_I dysbiosisCD Yes 0.577898108376082 0.435998189426125 803 495 0.185490138157935 0.467473718377322 -PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II diagnosis CD 0.847162696050949 0.63987049308045 803 783 0.185973418852375 0.467473718377322 -ILEUSYN_PWY_L_isoleucine_biosyn_I diagnosis UC 0.555863342520888 0.419959638970604 803 773 0.186089056432706 0.467473718377322 -GALACTUROCAT_PWY_D_galacturonate_deg_I dysbiosisUC Yes 0.464303305698028 0.352751902377862 803 776 0.188551773031941 0.472707261967401 -GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg antibiotics Yes -0.362607560790526 0.276468736658157 803 745 0.190122668606348 0.473344619804453 -PWY_6122_5_aminoimidazole_rnt_biosyn_II dysbiosisUC Yes 0.227942788317135 0.173886342917496 803 799 0.190355462151138 0.473344619804453 -PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn dysbiosisUC Yes 0.227942788317135 0.173886342917496 803 799 0.190355462151138 0.473344619804453 -SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I dysbiosisUC Yes 0.549977135714236 0.419664469840909 803 767 0.190475707846235 0.473344619804453 -P161_PWY_acetylene_deg diagnosis CD 1.6407677570152 1.25289651024493 803 537 0.190801479409992 0.473344619804453 -PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage dysbiosisCD Yes -0.385369805697191 0.294677992384167 803 754 0.191413666933556 0.473344619804453 -ANAGLYCOLYSIS_PWY_glycolysis_III dysbiosisnonIBD Yes -0.185209031820633 0.141640949118659 803 801 0.191465239471464 0.473344619804453 -PWY_5989_stearate_biosyn_II dysbiosisCD Yes 0.664193015031083 0.508736331088273 803 575 0.192158602150006 0.474118055997837 -PWY0_862_dodec_5_enoate_biosyn dysbiosisCD Yes 0.72427094245489 0.555993258096793 803 546 0.19319604493583 0.474458924176451 -RHAMCAT_PWY_L_rhamnose_deg_I diagnosis UC 1.30678018153283 1.00332674894787 803 709 0.193217831834026 0.474458924176451 -PWY_6168_flavin_biosyn_III dysbiosisUC Yes -0.395993537218854 0.30418934918161 803 760 0.193439111943529 0.474458924176451 -PWY_7400_L_arginine_biosyn_IV dysbiosisCD Yes 0.55485582322208 0.427664077575879 803 495 0.194956020572487 0.474818389855558 -PWY4FS_7_phosphatidylglycerol_biosyn_I diagnosis UC 1.79858575148524 1.38644306880807 803 604 0.194995640213547 0.474818389855558 -PWY4FS_8_phosphatidylglycerol_biosyn_II diagnosis UC 1.79858567370131 1.38644310351379 803 604 0.194995670662224 0.474818389855558 -PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I diagnosis CD 1.08128933754073 0.833732691615755 803 764 0.195109964370823 0.474818389855558 -PWY66_399_gluconeogenesis_III dysbiosisUC Yes -1.04462836792339 0.807334956994941 803 670 0.196186949778 0.475761895220209 -PWY66_409_SP_of_purine_nt_salvage age age 1.08221606174296 0.836631123944157 803 290 0.196316278505981 0.475761895220209 -PWY0_1479_tRNA_processing age age 2.15639258536636 1.66771688756312 803 414 0.196643158939332 0.475761895220209 -PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn dysbiosisnonIBD Yes -1.20994369221669 0.939247918288877 803 504 0.198140209716594 0.478454847493946 -PWY4FS_7_phosphatidylglycerol_biosyn_I age age -1.47617162060201 1.14964537195895 803 604 0.199587059139298 0.480087790902636 -PWY4FS_8_phosphatidylglycerol_biosyn_II age age -1.47617277067906 1.14964538772953 803 604 0.199586715492483 0.480087790902636 -GLUCONEO_PWY_gluconeogenesis_I diagnosis UC 4.14999451165689 3.23949135470638 803 457 0.200829649587634 0.482145941013857 -TRNA_CHARGING_PWY_tRNA_charging diagnosis CD 1.20882475600502 0.945065298692304 803 703 0.201316498411892 0.48238530196388 -PWY_6123_inosine_5_phosphate_biosyn_I antibiotics Yes 0.162147416420593 0.127096803898351 803 794 0.202481158944214 0.483317095870672 -PWY_6608_guanosine_nt_deg_III age age -1.04030615226501 0.815373062628794 803 686 0.202454727127938 0.483317095870672 -PWY_5188_tetrapyrrole_biosyn_I dysbiosisnonIBD Yes -0.701749323990647 0.551261214582409 803 731 0.203470245525741 0.484232456405156 -OANTIGEN_PWY_O_antigen_building_blocks_biosyn antibiotics Yes -0.49150026825836 0.386282998644269 803 445 0.203714497702911 0.484232456405156 -PWY_7664_oleate_biosyn_IV dysbiosisCD Yes 0.720925168497082 0.566960140830778 803 531 0.204030529384195 0.484232456405156 -PWY_6121_5_aminoimidazole_rnt_biosyn_I dysbiosisUC Yes 0.208375508581596 0.164197487508737 803 799 0.204867740177886 0.484919133085858 -PWY_4981_L_proline_biosyn_II diagnosis CD 1.57257619506301 1.24154955133792 803 678 0.205742138413926 0.484919133085858 -PWY_5173_SP_of_acetyl_CoA_biosyn diagnosis UC 1.82222166919662 1.43763471031314 803 335 0.205781924276148 0.484919133085858 -PWY_7560_methylerythritol_phosphate_pwy_II antibiotics Yes -0.589129261783171 0.46549453894802 803 226 0.206241553016725 0.484919133085858 -PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I dysbiosisCD Yes 0.715450545176197 0.565966355917082 803 557 0.206638652771964 0.484919133085858 -PWY_5083_NAD_NADH_phosphorylation__dephosphorylation diagnosis UC 1.63726614956015 1.29475570734074 803 431 0.206654943554246 0.484919133085858 -PANTO_PWY_phosphopantothenate_biosyn_I antibiotics Yes -0.142139219098649 0.112972222574459 803 798 0.208770793180707 0.487541070639116 -PWY_7220_adenosine_dnt_de_novo_biosyn_II dysbiosisUC Yes -0.445405112107069 0.354300391231356 803 783 0.209146369533901 0.487541070639116 -PWY_7222_guanosine_dnt_de_novo_biosyn_II dysbiosisUC Yes -0.445405112107069 0.354300391231356 803 783 0.209146369533901 0.487541070639116 -PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I antibiotics Yes 0.0762203047609252 0.0606554103214028 803 799 0.20933745809946 0.487541070639116 -PWY_5188_tetrapyrrole_biosyn_I diagnosis UC -1.1272202799731 0.898946512939081 803 731 0.210309668883944 0.488891506398124 -PWY_6270_isoprene_biosyn_I dysbiosisnonIBD Yes -0.874804938752339 0.698175292585073 803 219 0.210798242952604 0.489114731320195 -PWY_7456_mannan_deg antibiotics Yes -0.470870170851977 0.376207616881621 803 210 0.211379834015782 0.489552552385993 -THRESYN_PWY_SP_of_L_threonine_biosyn antibiotics Yes -0.12469067033212 0.0997793768616936 803 796 0.21186402666412 0.489763594106667 -COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn age age -0.495010959833069 0.397471316129581 803 773 0.213425875946441 0.489874292435748 -PWY_6700_queuosine_biosyn antibiotics Yes -0.256010396103045 0.20558349145076 803 780 0.213466966077437 0.489874292435748 -PWY_7220_adenosine_dnt_de_novo_biosyn_II diagnosis UC 0.842457654333716 0.6765430070888 803 783 0.21348454317224 0.489874292435748 -PWY_7222_guanosine_dnt_de_novo_biosyn_II diagnosis UC 0.842457654333716 0.6765430070888 803 783 0.21348454317224 0.489874292435748 -PWY_6385_peptidoglycan_biosyn_III antibiotics Yes 0.10958664047947 0.0882014807178276 803 797 0.214507535891631 0.491316892869434 -FUCCAT_PWY_fucose_deg dysbiosisUC Yes 1.22259319606107 0.986970836021467 803 268 0.215995901146585 0.493818151979165 -PWY_4242_pantothenate__coenzyme_A_biosyn_III age age -0.952681785375818 0.771327232866978 803 725 0.217223972688222 0.495682494162437 -PWY_621_sucrose_deg_III diagnosis CD 1.13165197492375 0.916992491931425 803 741 0.217607001851407 0.495682494162437 -P108_PWY_pyruvate_fermentation_to_propanoate_I age age 1.155780370699 0.937250850601921 803 350 0.218233058144843 0.496201442424223 -P441_PWY_SP_of_N_acetylneuraminate_deg dysbiosisCD Yes 0.718602083118916 0.584011306695167 803 433 0.218969614168383 0.496969288258297 -NONOXIPENT_PWY_pentose_phosphate_pwy diagnosis UC 0.426543205919161 0.347887708217183 803 800 0.220599073210559 0.498994044140594 -TCA_TCA_cyc_I diagnosis CD -1.43812747241858 1.17379052418418 803 412 0.220993154699757 0.498994044140594 -PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I antibiotics Yes -0.274153600259267 0.22382421747945 803 762 0.221063172043024 0.498994044140594 -PWY_5686_UMP_biosyn antibiotics Yes 0.0943589250742855 0.0773037040657543 803 802 0.222662180507661 0.501254273016677 -PWY_5347_SP_of_L_methionine_biosyn diagnosis CD -1.50653330643466 1.23614559047892 803 373 0.223387095802649 0.501254273016677 -PWY_4981_L_proline_biosyn_II dysbiosisUC Yes -0.844740325228292 0.693284783784837 803 678 0.223489615875769 0.501254273016677 -PWY_7197_pyrimidine_dnt_phosphorylation diagnosis UC 0.921360473287634 0.756477207414765 803 751 0.2236736563381 0.501254273016677 -PWY_6901_SP_of_glucose__xylose_deg diagnosis CD -1.17411849195534 0.967019189217835 803 436 0.225169776994267 0.503701152845344 -PWY_5154_L_arginine_biosyn_III age age -1.18809853779954 0.983397826359775 803 475 0.22743188319751 0.507537897816556 -PWY66_400_glycolysis_VI diagnosis CD 0.559908756478591 0.463718599526434 803 789 0.227699586580622 0.507537897816556 -PWY0_1296_purine_rns_deg dysbiosisUC Yes -0.364336334548848 0.302546418556914 803 793 0.228929973588511 0.508729749361552 -PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn antibiotics Yes -0.615652166464836 0.511515897234869 803 504 0.229195536480599 0.508729749361552 -FASYN_ELONG_PWY_fatty_acid_elongation__saturated dysbiosisCD Yes 0.676116844569362 0.562025050223903 803 532 0.229459164639801 0.508729749361552 -PWY_5097_L_lysine_biosyn_VI diagnosis UC -0.294959493865239 0.245882353948726 803 802 0.230725428999245 0.510628569330478 -PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I age age -0.592489839327088 0.495037181033106 803 762 0.231789840905533 0.51207471944733 -GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg diagnosis CD 1.83868803643383 1.54267490252527 803 300 0.233970663663732 0.514129459181007 -PWY_5484_glycolysis_II diagnosis CD 0.51136103609676 0.429170940657752 803 791 0.233882113963776 0.514129459181007 -PWY_5913_TCA_cyc_VI diagnosis CD -1.86995249108782 1.56961667643692 803 146 0.234352219329815 0.514129459181007 -PWY_5100_pyruvate_fermentation_to_acetate__lactate_II diagnosis CD -0.851528621881248 0.715896501966577 803 778 0.234686681036463 0.514129459181007 -PWY_4242_pantothenate__coenzyme_A_biosyn_III dysbiosisnonIBD Yes -0.72446595561709 0.609314714342053 803 725 0.234871943368397 0.514129459181007 -PENTOSE_P_PWY_pentose_phosphate_pwy antibiotics Yes -0.47135134899647 0.397225814195298 803 613 0.23581913498954 0.514129459181007 -ARGSYNBSUB_PWY_L_arginine_biosyn_II dysbiosisCD Yes 0.809415014013232 0.68232911146377 803 428 0.235971677762113 0.514129459181007 -PWY_6317_galactose_deg_I diagnosis CD -0.826248831889133 0.696628471481835 803 765 0.236020907424989 0.514129459181007 -PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II dysbiosisCD Yes 0.291503604128375 0.246592783254396 803 783 0.237580360002664 0.516623261018009 -PWY_6151_S_adenosyl_L_methionine_cyc_I diagnosis UC 0.459281794319855 0.390267773428281 803 791 0.239683291542551 0.520288120665538 -PWY_5971_palmitate_biosyn_II diagnosis UC 1.34010844288806 1.14272437259384 803 143 0.241478128445782 0.522185102391997 -PWY0_862_dodec_5_enoate_biosyn antibiotics Yes -0.548584028117238 0.468301860287749 803 546 0.241895430661923 0.522185102391997 -PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III dysbiosisUC Yes -0.796084362303706 0.680363693267663 803 512 0.242398326650529 0.522185102391997 -PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I antibiotics Yes -0.336474027011144 0.287790805644078 803 764 0.242760513018008 0.522185102391997 -PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II dysbiosisUC Yes -0.389248924590447 0.33310785724363 803 783 0.243010768218515 0.522185102391997 -ARGSYN_PWY_L_arginine_biosyn_I age age -1.02370612121779 0.876433981893638 803 495 0.243225970351143 0.522185102391997 -PWY_6545_pyrimidine_dnt_de_novo_biosyn_III antibiotics Yes -0.34606626700887 0.296700015306135 803 651 0.243880991977448 0.522185102391997 -PWY0_1297_SP_of_purine_dns_deg dysbiosisCD Yes 0.536391390746865 0.459902909089628 803 610 0.243909895338798 0.522185102391997 -PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisUC Yes -0.424351513301453 0.364532588888646 803 742 0.244805090552183 0.52320264636024 -PWY_6545_pyrimidine_dnt_de_novo_biosyn_III dysbiosisCD Yes -0.40849075255316 0.354403313289254 803 651 0.249486162582386 0.531899087556814 -PWY_7400_L_arginine_biosyn_IV age age -0.990646539349291 0.859896290713298 803 495 0.249727902263833 0.531899087556814 -COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I dysbiosisCD Yes -0.426760372521543 0.371910469314354 803 578 0.251601633219479 0.534149833590282 -PANTO_PWY_phosphopantothenate_biosyn_I dysbiosisUC Yes -0.200946037476335 0.175355533851485 803 798 0.25223612236429 0.534149833590282 -PWY_7220_adenosine_dnt_de_novo_biosyn_II diagnosis CD 0.774015490495258 0.675819879048169 803 783 0.252499399666674 0.534149833590282 -PWY_7222_guanosine_dnt_de_novo_biosyn_II diagnosis CD 0.774015490495258 0.675819879048169 803 783 0.252499399666674 0.534149833590282 -PWY_6737_starch_deg_V age age 0.43992867939375 0.385492534819602 803 800 0.25419439170382 0.536824088242305 -PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II dysbiosisCD Yes -0.140027968141751 0.123040634652425 803 794 0.255505967572289 0.538680940093185 -PWY_6936_seleno_amino_acid_biosyn dysbiosisUC Yes -0.896170110707609 0.790501242703718 803 472 0.257343878296285 0.541363136435659 -PWY_841_SP_of_purine_nt_de_novo_biosyn_I dysbiosisCD Yes 0.536233719723082 0.473304855775715 803 651 0.257647142781979 0.541363136435659 -PWY_6151_S_adenosyl_L_methionine_cyc_I dysbiosisCD Yes -0.178561850026852 0.157953217274659 803 791 0.258686362203857 0.542631662131323 -HISTSYN_PWY_L_histidine_biosyn antibiotics Yes 0.309529962225669 0.274198996889012 803 698 0.259369984907713 0.543151262512623 -PWY_6608_guanosine_nt_deg_III antibiotics Yes -0.420503034753613 0.373698213460462 803 686 0.260895632289094 0.545429459450019 -SALVADEHYPOX_PWY_adenosine_nt_deg_II dysbiosisUC Yes -0.776732257629148 0.692253122744558 803 638 0.262259949715087 0.547363312135676 -SALVADEHYPOX_PWY_adenosine_nt_deg_II age age -1.04852930188541 0.936316013246388 803 638 0.263191310010704 0.548388582396885 -PWY_6317_galactose_deg_I antibiotics Yes 0.27057681886232 0.242632620169199 803 765 0.265181886550783 0.551515551042495 -PWY_2942_L_lysine_biosyn_III diagnosis UC 0.241929012278755 0.217230652220931 803 802 0.26581361776028 0.551515551042495 -ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn dysbiosisUC Yes 0.363654192197601 0.326648001527874 803 732 0.266019940751637 0.551515551042495 -SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I antibiotics Yes -0.29465350516007 0.266634596475223 803 767 0.269524858014817 0.557853775891133 -PWY_5667_CDP_diacylglycerol_biosyn_I diagnosis CD -0.266828928697915 0.242111076852295 803 801 0.270821743841654 0.558681941766061 -PWY0_1319_CDP_diacylglycerol_biosyn_II diagnosis CD -0.266832784850525 0.24211214921419 803 801 0.270816945809015 0.558681941766061 -PWY_7237_myo__chiro__scillo_inositol_deg antibiotics Yes 0.610664129674414 0.555881601218921 803 441 0.272380432824041 0.560968626940091 -COA_PWY_coenzyme_A_biosyn_I antibiotics Yes -0.264111350908126 0.240849287775334 803 774 0.273222248768505 0.561773798623032 -PWY_7184_pyrimidine_dnt_de_novo_biosyn_I dysbiosisUC Yes -0.425305344594653 0.388564882586717 803 747 0.274111253419302 0.562357820044362 -PWY66_422_D_galactose_deg_V diagnosis UC -0.626085841091582 0.572357465222408 803 785 0.274408952316992 0.562357820044362 -PWY_6703_preQ0_biosyn dysbiosisUC Yes -0.418488183407661 0.383318379076446 803 771 0.27533977741399 0.562581044421934 -PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I dysbiosisUC Yes -0.294761044659366 0.27074561831598 803 792 0.276681902869171 0.562581044421934 -ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn diagnosis CD 1.40865835391194 1.29430596035339 803 732 0.276868171789019 0.562581044421934 -RHAMCAT_PWY_L_rhamnose_deg_I antibiotics Yes 0.373210506523436 0.343153178647112 803 709 0.277172460178001 0.562581044421934 -PWY0_1479_tRNA_processing dysbiosisUC Yes -0.844538328047725 0.77648784229265 803 414 0.277315595069473 0.562581044421934 -TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA age age -1.190334577455 1.09391098655145 803 159 0.277373312432812 0.562581044421934 -PWY_5154_L_arginine_biosyn_III dysbiosisUC Yes -0.735185420098508 0.676672876409946 803 475 0.277678444879205 0.562581044421934 -PWY66_422_D_galactose_deg_V antibiotics Yes 0.219490440072689 0.202436300978454 803 785 0.278651128912983 0.563635238028534 -PYRIDNUCSYN_PWY_NAD_biosyn_I age age -0.73721209058644 0.680605013924611 803 707 0.2791295747106 0.563687925590612 -PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn dysbiosisUC Yes 0.783492756395576 0.724822011880052 803 281 0.280150128696566 0.564833430996636 -PWY_5097_L_lysine_biosyn_VI dysbiosisnonIBD Yes -0.162842292161198 0.150996450125075 803 802 0.281225273666394 0.566085122759817 -PWY_5104_L_isoleucine_biosyn_IV antibiotics Yes 0.640649899179814 0.599794835058098 803 475 0.285875133254976 0.571371207653498 -SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I dysbiosisCD Yes -0.333955604200308 0.312732016683771 803 767 0.285970620616603 0.571371207653498 -ARGSYNBSUB_PWY_L_arginine_biosyn_II dysbiosisnonIBD Yes 1.08359833416966 1.01525012372385 803 428 0.286237437005575 0.571371207653498 -PENTOSE_P_PWY_pentose_phosphate_pwy diagnosis CD 1.16871977753634 1.09538730797171 803 613 0.286395132027876 0.571371207653498 -PWY0_1296_purine_rns_deg antibiotics Yes 0.20853892005845 0.195492885284891 803 793 0.28648080891318 0.571371207653498 -DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I dysbiosisnonIBD Yes -0.25728000478517 0.241245552185671 803 790 0.286602732570976 0.571371207653498 -PWY_5101_L_isoleucine_biosyn_II diagnosis UC 1.26432290176532 1.186941441813 803 574 0.287209587388528 0.571666367230201 -RHAMCAT_PWY_L_rhamnose_deg_I dysbiosisCD Yes 0.424388289075949 0.399502155758406 803 709 0.288491290807927 0.572981158507996 -GALACTUROCAT_PWY_D_galacturonate_deg_I diagnosis UC -0.670216277015703 0.63138490396912 803 776 0.288848964051925 0.572981158507996 -PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II antibiotics Yes -0.237187267702997 0.223801202383529 803 769 0.289616518762272 0.572981158507996 -P108_PWY_pyruvate_fermentation_to_propanoate_I dysbiosisCD Yes 0.613313384353621 0.57851545461454 803 350 0.289709574526515 0.572981158507996 -PWY_7187_pyrimidine_dnt_de_novo_biosyn_II age age -0.799704576842213 0.756663774812145 803 647 0.290952565512443 0.574527569934238 -COA_PWY_1_coenzyme_A_biosyn_II diagnosis CD -0.28050511560342 0.265833208707931 803 800 0.291722393235112 0.574597571101171 -PWY_4984_urea_cyc diagnosis CD -1.16316044155363 1.10271475583813 803 665 0.291910323039359 0.574597571101171 -PWY_6123_inosine_5_phosphate_biosyn_I diagnosis UC 0.379563893916651 0.360709188236753 803 794 0.293059073612231 0.57594890492246 -PWY66_409_SP_of_purine_nt_salvage dysbiosisnonIBD Yes -0.696734995800971 0.664666662740737 803 290 0.294941906206713 0.57780234809699 -PWY0_1479_tRNA_processing diagnosis UC -1.22987246694293 1.17429509751152 803 414 0.29548994223386 0.57780234809699 -ILEUSYN_PWY_L_isoleucine_biosyn_I diagnosis CD -0.443196635872668 0.423538378780837 803 773 0.295751685303104 0.57780234809699 -PWY_5154_L_arginine_biosyn_III dysbiosisCD Yes 0.512645972719797 0.4900021661592 803 475 0.295857061064109 0.57780234809699 -PWY_7242_D_fructuronate_deg antibiotics Yes -0.217720251980503 0.209273116082237 803 773 0.298550548481302 0.582150208775747 -PWY_7221_guanosine_rnt_de_novo_biosyn diagnosis CD 0.205037930581034 0.198240931666231 803 802 0.301379896205139 0.58674898542438 -PWY_7663_gondoate_biosyn age age -0.379776287705405 0.36769060004985 803 792 0.302042301971838 0.587121229729969 -PWY_3001_SP_of_L_isoleucine_biosyn_I dysbiosisUC Yes -0.228274536779293 0.221484514196159 803 782 0.303078152182658 0.588066163754283 -PWY_5659_GDP_mannose_biosyn dysbiosisCD Yes -0.242650220787148 0.23564779867924 803 788 0.303520149971544 0.588066163754283 -PWY_5101_L_isoleucine_biosyn_II antibiotics Yes -0.367059503428718 0.35714587188678 803 574 0.30447106407899 0.588066163754283 -PWY4FS_7_phosphatidylglycerol_biosyn_I dysbiosisCD Yes 0.582840148370823 0.567622001450563 803 604 0.304888235782718 0.588066163754283 -PWY4FS_8_phosphatidylglycerol_biosyn_II dysbiosisCD Yes 0.582841660437072 0.567621996321664 803 604 0.304886977773875 0.588066163754283 -PWY_5101_L_isoleucine_biosyn_II age age -0.753074608281392 0.736558530627787 803 574 0.306985891043415 0.588294565035635 -CITRULBIO_PWY_L_citrulline_biosyn dysbiosisnonIBD Yes -0.706154586084224 0.691172749758433 803 688 0.307321530182775 0.588294565035635 -PWY_6609_adenine__adenosine_salvage_III dysbiosisnonIBD Yes -0.274667183953352 0.268806313789859 803 792 0.307247249261642 0.588294565035635 -PWY_6122_5_aminoimidazole_rnt_biosyn_II diagnosis UC 0.324774135285086 0.318390322604216 803 799 0.308077244297196 0.588294565035635 -PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn diagnosis UC 0.324774135285086 0.318390322604216 803 799 0.308077244297196 0.588294565035635 -PWY_7388_octanoyl_acyl_carrier_protein_biosyn dysbiosisCD Yes 0.574935201863448 0.563996511567591 803 535 0.30843402217081 0.588294565035635 -OANTIGEN_PWY_O_antigen_building_blocks_biosyn age age -0.836358603326961 0.821009866745789 803 445 0.308745792890634 0.588294565035635 -PWY_7560_methylerythritol_phosphate_pwy_II dysbiosisnonIBD Yes -0.728120618765905 0.714680268121931 803 226 0.308783824665574 0.588294565035635 -P105_PWY_TCA_cyc_IV diagnosis CD -1.29502297014532 1.27312059960994 803 101 0.309977379630859 0.589666893160382 -PWY_5913_TCA_cyc_VI dysbiosisCD Yes 0.662455333784092 0.653450673356064 803 146 0.311410666508698 0.591490381813777 -BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn dysbiosisCD Yes -0.255597548472691 0.252888540162276 803 773 0.312523434865381 0.59270045638092 -PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I dysbiosisCD Yes -0.334982479196274 0.332065621047094 803 764 0.313447932596458 0.593550340448612 -GLYCOGENSYNTH_PWY_glycogen_biosyn_I antibiotics Yes -0.396198985735504 0.394435432631905 803 706 0.315519164334878 0.596565825130892 -PWY_4041_beta_glutamyl_cyc age age -1.23622678982527 1.23448651742333 803 247 0.317392556071068 0.599198674037198 -PWY_6527_stachyose_deg diagnosis CD 0.730439664353856 0.732952735400734 803 766 0.319336761892936 0.601240181765569 -NAGLIPASYN_PWY_lipid_IVA_biosyn dysbiosisnonIBD Yes 0.673391998851967 0.676491095778862 803 601 0.319921541340748 0.601240181765569 -PWY_6609_adenine__adenosine_salvage_III antibiotics Yes 0.153166513109023 0.153875747042453 803 792 0.319909888390976 0.601240181765569 -PWY_7197_pyrimidine_dnt_phosphorylation dysbiosisCD Yes -0.303090991607394 0.307091560786735 803 751 0.324017694374375 0.608021155407336 -PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage antibiotics Yes -0.245970055326543 0.250464478975927 803 754 0.326436700468447 0.611639291404038 -RIBOSYN2_PWY_flavin_biosyn_I antibiotics Yes -0.417224588384014 0.426129262717997 803 478 0.327926173659308 0.613507526095342 -CITRULBIO_PWY_L_citrulline_biosyn dysbiosisCD Yes -0.428249261045945 0.440908377063453 803 688 0.331772689233004 0.618647583623466 -PWY0_1586_peptidoglycan_maturation antibiotics Yes -0.290831973295111 0.300053533818835 803 773 0.332766535346481 0.618647583623466 -NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I dysbiosisnonIBD Yes -0.155165952200262 0.16009801639783 803 799 0.332802625342021 0.618647583623466 -PWY_6969_TCA_cyc_V diagnosis UC 1.14880897192365 1.18565169378214 803 403 0.332983118535971 0.618647583623466 -PWY_4984_urea_cyc dysbiosisnonIBD Yes -0.668218432168262 0.689942281562475 803 665 0.333156122481016 0.618647583623466 -PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I dysbiosisCD Yes 0.493532165777936 0.510116209995296 803 561 0.333660247683279 0.61866170924608 -PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I antibiotics Yes -0.169397325520712 0.175635548544001 803 783 0.335156510397909 0.620512647779784 -FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation antibiotics Yes -0.443020764470801 0.461819705337714 803 539 0.337803717191092 0.62263821245577 -PWY_5173_SP_of_acetyl_CoA_biosyn dysbiosisUC Yes -0.80043266686764 0.833487996724732 803 335 0.337521109389626 0.62263821245577 -PWY_5989_stearate_biosyn_II diagnosis CD 1.20331750880713 1.25399246396905 803 575 0.337618303852684 0.62263821245577 -DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I antibiotics Yes 0.132593923444584 0.138856815362431 803 790 0.339978986211009 0.625722033705934 -PWY_5083_NAD_NADH_phosphorylation__dephosphorylation antibiotics Yes 0.523919889212092 0.55017286911474 803 431 0.341436113310587 0.62743502056106 -PWY_6737_starch_deg_V dysbiosisUC Yes 0.259784379267084 0.273150098176029 803 800 0.341916837047319 0.62743502056106 -THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III dysbiosisnonIBD Yes -0.484537876695141 0.510374107931502 803 682 0.342775441051159 0.628085587573153 -GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg diagnosis UC -0.740266329102663 0.784916817961178 803 745 0.345968023891431 0.633004636958477 -PWY_5667_CDP_diacylglycerol_biosyn_I antibiotics Yes -0.080035446928062 0.0852269789516367 803 801 0.348029190123302 0.633481051863243 -PWY0_1319_CDP_diacylglycerol_biosyn_II antibiotics Yes -0.0800247353208051 0.0852273710377117 803 801 0.348095885519523 0.633481051863243 -PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine dysbiosisnonIBD Yes 0.626421875980899 0.667363845407499 803 597 0.348252708574048 0.633481051863243 -PWY66_409_SP_of_purine_nt_salvage antibiotics Yes -0.379253860702621 0.404439631418577 803 290 0.348757808094792 0.633481051863243 -PWY_7187_pyrimidine_dnt_de_novo_biosyn_II antibiotics Yes -0.322562339601867 0.344650395386015 803 647 0.349661482914843 0.633481051863243 -ILEUSYN_PWY_L_isoleucine_biosyn_I dysbiosisCD Yes -0.161231934924843 0.172430173340669 803 773 0.350100191316222 0.633481051863243 -PWY_6163_chorismate_biosyn_from_3_dehydroquinate dysbiosisnonIBD Yes -0.31136092083212 0.332785028069786 803 787 0.349809640316756 0.633481051863243 -PWY_5913_TCA_cyc_VI diagnosis UC -1.52161104152195 1.62685672821261 803 146 0.350295702033527 0.633481051863243 -PWY0_862_dodec_5_enoate_biosyn age age -1.04339619125508 1.12050953764837 803 546 0.352139340792647 0.635892200909621 -PWY_4041_beta_glutamyl_cyc dysbiosisUC Yes -0.877428707829163 0.947102297651923 803 247 0.354924740326871 0.639877843655734 -OANTIGEN_PWY_O_antigen_building_blocks_biosyn dysbiosisUC Yes 0.52876442718275 0.571693343464212 803 445 0.355373569670761 0.639877843655734 -COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I dysbiosisnonIBD Yes -0.511185690526373 0.553801483394236 803 578 0.356321762910895 0.640648757260682 -PWY_841_SP_of_purine_nt_de_novo_biosyn_I antibiotics Yes 0.381375063014371 0.413606184116642 803 651 0.356830046178903 0.640648757260682 -P108_PWY_pyruvate_fermentation_to_propanoate_I dysbiosisUC Yes -1.07813254676626 1.17083818779066 803 350 0.357693335410694 0.640810811196031 -PWY66_400_glycolysis_VI dysbiosisnonIBD Yes 0.257403176711682 0.279977687957931 803 789 0.358238807548098 0.640810811196031 -PYRIDNUCSYN_PWY_NAD_biosyn_I dysbiosisCD Yes -0.332443892859478 0.361768118167307 803 707 0.358463190532611 0.640810811196031 -UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I antibiotics Yes -0.395650826847706 0.431560706142015 803 503 0.359607665078209 0.640881006351497 -FUCCAT_PWY_fucose_deg diagnosis UC 1.47272327596009 1.60687948584449 803 268 0.359817967071851 0.640881006351497 -PWY_7196_SP_of_pyrimidine_rns_salvage dysbiosisUC Yes 0.607288067128067 0.663006893208041 803 411 0.360045509186234 0.640881006351497 -PWY_7196_SP_of_pyrimidine_rns_salvage age age -0.948316940486702 1.04012245689564 803 411 0.362263859732446 0.643909799182065 -THRESYN_PWY_SP_of_L_threonine_biosyn diagnosis UC -0.260248259440548 0.285978810258904 803 796 0.363139812065026 0.644547301756442 -GLUCONEO_PWY_gluconeogenesis_I antibiotics Yes -0.531087241085523 0.586108894159382 803 457 0.365354147279252 0.647555145817849 -PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I diagnosis UC -0.674011115837354 0.747695459713895 803 765 0.367679706694114 0.65075129906373 -PWY_6897_thiamin_salvage_II dysbiosisUC Yes -0.497617110396921 0.553278486063194 803 589 0.368768664107557 0.651752844649668 -PWY_6151_S_adenosyl_L_methionine_cyc_I age age 0.268631143888525 0.299908547390022 803 791 0.370733136010841 0.654296724461059 -PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I dysbiosisnonIBD Yes -0.272392830934299 0.304907679540148 803 783 0.371988170883008 0.655583113041341 -PWYG_321_mycolate_biosyn diagnosis CD 1.20292761359005 1.35506450879848 803 484 0.375059982011505 0.660063188681264 -PWY0_1319_CDP_diacylglycerol_biosyn_II dysbiosisCD Yes -0.0896228180427419 0.10268356941279 803 801 0.383085385850179 0.671692162716922 -PWY_5667_CDP_diacylglycerol_biosyn_I dysbiosisCD Yes -0.0895855434937827 0.10268384217771 803 801 0.383284428140994 0.671692162716922 -BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn diagnosis CD -0.534824744591637 0.613289072873012 803 773 0.383491922928683 0.671692162716922 -PWY_7199_pyrimidine_dns_salvage diagnosis CD 0.962773469281325 1.10527388660761 803 694 0.38403092494279 0.671692162716922 -PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine dysbiosisCD Yes 0.392313369844377 0.450694805193651 803 597 0.384363171763375 0.671692162716922 -RHAMCAT_PWY_L_rhamnose_deg_I dysbiosisnonIBD Yes 0.517815788209144 0.596033006791121 803 709 0.385288571433819 0.672197329363326 -PWY_7388_octanoyl_acyl_carrier_protein_biosyn antibiotics Yes -0.405730081544606 0.467414597177024 803 535 0.385731212275103 0.672197329363326 -TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA dysbiosisCD Yes 0.523006311207497 0.603991589996494 803 159 0.387203432890741 0.673640009681663 -PWY_5083_NAD_NADH_phosphorylation__dephosphorylation dysbiosisUC Yes 0.68413147770564 0.791661949539427 803 431 0.387928181203896 0.673640009681663 -PWY0_1261_anhydromuropeptides_recycling antibiotics Yes 0.471000825804981 0.545386394102133 803 273 0.388181000763591 0.673640009681663 -P108_PWY_pyruvate_fermentation_to_propanoate_I dysbiosisnonIBD Yes -0.792711728131348 0.920132023801051 803 350 0.389462998331318 0.674924750932993 -PENTOSE_P_PWY_pentose_phosphate_pwy diagnosis UC 0.943417503117892 1.09704404294026 803 613 0.390128847513039 0.675139644446176 -PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg diagnosis UC -0.704532118130974 0.820914172303009 803 757 0.391077739985184 0.67584308463459 -PWY_7663_gondoate_biosyn antibiotics Yes -0.142692255019816 0.167023726176913 803 792 0.393234945976585 0.677540652603297 -PWY_6124_inosine_5_phosphate_biosyn_II diagnosis UC 0.383662840941028 0.449148100438753 803 792 0.393302521708591 0.677540652603297 -PWY_7388_octanoyl_acyl_carrier_protein_biosyn diagnosis UC -1.10273057487715 1.29441599528454 803 535 0.394608297176164 0.677540652603297 -SALVADEHYPOX_PWY_adenosine_nt_deg_II dysbiosisCD Yes -0.428474647233312 0.503214740234914 803 638 0.394817821234397 0.677540652603297 -NONOXIPENT_PWY_pentose_phosphate_pwy antibiotics Yes -0.104006904841674 0.122328046410582 803 800 0.395504939259194 0.677540652603297 -PWY_5103_L_isoleucine_biosyn_III diagnosis CD -0.525859342966692 0.618537330290957 803 778 0.395540229752929 0.677540652603297 -TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA antibiotics Yes 0.637048893707968 0.750290903586147 803 159 0.396495873998077 0.677540652603297 -PWY_5667_CDP_diacylglycerol_biosyn_I diagnosis UC -0.205032334931668 0.24188903651242 803 801 0.396950566365793 0.677540652603297 -PWY0_1319_CDP_diacylglycerol_biosyn_II diagnosis UC -0.205031757835684 0.241890112721709 803 801 0.396953993900808 0.677540652603297 -PWY_5177_glutaryl_CoA_deg antibiotics Yes 0.253494511102075 0.299428713257656 803 753 0.39753263059365 0.677600078959901 -PWY_4984_urea_cyc diagnosis UC -0.890127973200865 1.05270076319921 803 665 0.398112896827002 0.677662116730115 -PWY_6317_galactose_deg_I dysbiosisUC Yes -0.314460398642939 0.372861399185825 803 765 0.399325748743953 0.678799294590676 -PWY_7383_anaerobic_energy_metabolism diagnosis UC 0.983074694135716 1.17117886802994 803 698 0.401579872061648 0.681700981728629 -P441_PWY_SP_of_N_acetylneuraminate_deg age age -0.929768143031518 1.11155475001706 803 433 0.403204583011667 0.682817295209947 -VALSYN_PWY_L_valine_biosyn dysbiosisnonIBD Yes 0.158061631105367 0.189019441191505 803 802 0.403333490589503 0.682817295209947 -ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn diagnosis CD 0.306420336405942 0.370145990798483 803 797 0.408061916431313 0.68988486821359 -PWY_7208_SP_of_pyrimidine_nucleobases_salvage age age -0.276740849927624 0.335498540821335 803 794 0.40974561741976 0.691792736185665 -PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn age age -0.588231447703823 0.720894613967766 803 604 0.414812856738153 0.699400297017238 -PWY_5690_TCA_cyc_II dysbiosisUC Yes 0.671854734039629 0.826164108702709 803 363 0.41640607821438 0.699547059314385 -GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg antibiotics Yes 0.212983217110617 0.262227693293801 803 757 0.416965159496345 0.699547059314385 -ILEUSYN_PWY_L_isoleucine_biosyn_I age age 0.267934851706032 0.32991397781374 803 773 0.417005820215851 0.699547059314385 -PWY_5971_palmitate_biosyn_II diagnosis CD 0.935683342340031 1.15274501374422 803 143 0.417361051923587 0.699547059314385 -PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I dysbiosisnonIBD Yes 0.619887597684318 0.764421361882443 803 561 0.417707072335395 0.699547059314385 -PWY_4984_urea_cyc antibiotics Yes -0.303957936822147 0.375502486325667 803 665 0.418547675577143 0.700013964790765 -ANAEROFRUCAT_PWY_homolactic_fermentation diagnosis UC -0.509606599099301 0.632578228276183 803 770 0.420762227699165 0.70231092687629 -ILEUSYN_PWY_L_isoleucine_biosyn_I antibiotics Yes -0.118806265493416 0.147566242672105 803 773 0.421048364668209 0.70231092687629 -PWY_5030_L_histidine_deg_III dysbiosisCD Yes -0.40625509585793 0.505522132247783 803 542 0.421914524863718 0.702357960472706 -PWY_6317_galactose_deg_I diagnosis UC -0.550357508607014 0.685289553325753 803 765 0.422203942531346 0.702357960472706 -GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg dysbiosisnonIBD Yes -0.388469963285876 0.484904982764822 803 745 0.423347479878898 0.703081512022043 -PWY_5154_L_arginine_biosyn_III antibiotics Yes 0.347536416039966 0.434196170083134 803 475 0.423767428193061 0.703081512022043 -PWY_6703_preQ0_biosyn dysbiosisCD Yes -0.226763827425908 0.28510804452728 803 771 0.426688599377411 0.706986695245019 -GLYCOLYSIS_glycolysis_I diagnosis CD 0.337750855690684 0.425852123659871 803 791 0.427994271661194 0.708188600345857 -FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation diagnosis UC -1.01328863275264 1.27904929044796 803 539 0.428550726051987 0.708188600345857 -PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II dysbiosisUC Yes 0.130950086340044 0.166255195840879 803 794 0.43118625652643 0.711600100174744 -PWY_6163_chorismate_biosyn_from_3_dehydroquinate antibiotics Yes 0.154003418130768 0.196150484955233 803 787 0.432659295216947 0.713086616190894 -PWY_5723_Rubisco_shunt antibiotics Yes 0.562441702721196 0.718854174624088 803 212 0.434557102654255 0.713942177946653 -ARGSYNBSUB_PWY_L_arginine_biosyn_II age age -1.05691633111509 1.35319201313643 803 428 0.435065400698422 0.713942177946653 -GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg dysbiosisCD Yes -0.244446179448656 0.312906638292516 803 755 0.434957548266288 0.713942177946653 -PWY_6897_thiamin_salvage_II dysbiosisnonIBD Yes 0.47970621961893 0.615193568427109 803 589 0.435808502003039 0.713942177946653 -PWY_6282_palmitoleate_biosyn_I antibiotics Yes -0.370435632071291 0.475268745934946 803 531 0.436043336611078 0.713942177946653 -GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg dysbiosisnonIBD Yes -0.357247193868808 0.459431616383954 803 757 0.437091839329949 0.714719726778368 -PWY_6121_5_aminoimidazole_rnt_biosyn_I dysbiosisCD Yes -0.0959501864198222 0.124312527995328 803 799 0.440480796811856 0.718906824426547 -PWY_7664_oleate_biosyn_IV antibiotics Yes -0.362908468087241 0.470482348655942 803 531 0.440806431670852 0.718906824426547 -GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff diagnosis UC 1.02138014533073 1.32614858751738 803 412 0.441484290881378 0.719071145670846 -PYRIDNUCSYN_PWY_NAD_biosyn_I dysbiosisnonIBD Yes -0.410055681357359 0.537869879204192 803 707 0.44611301131502 0.725661634593362 -NONOXIPENT_PWY_pentose_phosphate_pwy diagnosis CD 0.267839984648823 0.352843901136638 803 800 0.448069409413504 0.727893721159356 -PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I age age -0.101446025427474 0.134474933435165 803 799 0.450885654019216 0.729105585054641 -PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I dysbiosisnonIBD Yes -0.340473447493271 0.451671167182751 803 765 0.451235261520482 0.729105585054641 -GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg diagnosis UC -1.05298970807154 1.39678188007537 803 300 0.451344725353928 0.729105585054641 -P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate diagnosis CD 1.15810618385204 1.53762842833838 803 283 0.451630450764485 0.729105585054641 -P105_PWY_TCA_cyc_IV dysbiosisUC Yes 0.607834190724469 0.80883873100535 803 101 0.45301971218106 0.729105585054641 -CITRULBIO_PWY_L_citrulline_biosyn diagnosis UC 0.791533231811341 1.05493595931527 803 688 0.453342216711741 0.729105585054641 -PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisCD Yes -0.198332146371801 0.264641891460776 803 742 0.453861523346787 0.729105585054641 -NAGLIPASYN_PWY_lipid_IVA_biosyn antibiotics Yes 0.300966929242074 0.402135772514733 803 601 0.454490417929266 0.729105585054641 -GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg dysbiosisCD Yes -0.231174980488433 0.309016865436411 803 757 0.45466696596104 0.729105585054641 -PWY_6353_purine_nt_deg_II dysbiosisCD Yes 0.401522165470731 0.536667715587135 803 432 0.454630278185881 0.729105585054641 -NONOXIPENT_PWY_pentose_phosphate_pwy dysbiosisnonIBD Yes 0.159588535763436 0.213927915600698 803 800 0.455936994064388 0.729479353392994 -PWY66_399_gluconeogenesis_III antibiotics Yes -0.372656161210505 0.49966481362676 803 670 0.456070960106856 0.729479353392994 -PWY66_399_gluconeogenesis_III dysbiosisnonIBD Yes 0.586980955748546 0.790927216283242 803 670 0.458289302122254 0.732087782620934 -PANTO_PWY_phosphopantothenate_biosyn_I dysbiosisnonIBD Yes -0.145580164176812 0.19684374790554 803 798 0.459821782935226 0.733595315668747 -PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn age age -0.338850474284119 0.460259982132439 803 761 0.461861217198634 0.735906747608054 -PWY_5100_pyruvate_fermentation_to_acetate__lactate_II diagnosis UC 0.517243129730338 0.706545884224152 803 778 0.464383520649095 0.738581939444385 -PWY_6545_pyrimidine_dnt_de_novo_biosyn_III dysbiosisnonIBD Yes -0.375772215605417 0.514687489902717 803 651 0.465589841396914 0.738581939444385 -FASYN_ELONG_PWY_fatty_acid_elongation__saturated antibiotics Yes -0.340684950784805 0.466656596709158 803 532 0.465646860132907 0.738581939444385 -ANAEROFRUCAT_PWY_homolactic_fermentation antibiotics Yes -0.159934975083337 0.219217808743128 803 770 0.465911239488994 0.738581939444385 -PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine age age 0.607528381279747 0.839377653783895 803 597 0.469454224608048 0.743252813038917 -P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate diagnosis UC 1.10894009155151 1.5345231805637 803 283 0.470161549316311 0.743428033563609 -PWY_5695_urate_biosyn_inosine_5_phosphate_deg diagnosis UC -0.203072663315691 0.282661867220382 803 800 0.47274589508741 0.746567028236898 -PWY_6545_pyrimidine_dnt_de_novo_biosyn_III diagnosis CD -0.6020252860461 0.839774220242335 803 651 0.47369630290293 0.747121004325381 -PWY_5097_L_lysine_biosyn_VI diagnosis CD 0.175464284284432 0.245650897338589 803 802 0.475303915439987 0.748149019710031 -HISDEG_PWY_L_histidine_deg_I dysbiosisUC Yes -0.68858678487055 0.965272419775363 803 582 0.475891405630738 0.748149019710031 -THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III dysbiosisCD Yes 0.251527991379747 0.353351115036169 803 682 0.476817578889886 0.748149019710031 -HISTSYN_PWY_L_histidine_biosyn diagnosis CD -0.552103372975818 0.77644789096416 803 698 0.477296022866921 0.748149019710031 -PWY_6545_pyrimidine_dnt_de_novo_biosyn_III diagnosis UC 0.596621145500916 0.839157226486277 803 651 0.47735029748754 0.748149019710031 -GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg dysbiosisCD Yes -0.230896614012275 0.326312498817837 803 745 0.479447870981231 0.750492521661575 -PWY_6737_starch_deg_V diagnosis UC -0.351120453765549 0.497121062935706 803 800 0.480245282078279 0.750797517527648 -PWY_5484_glycolysis_II diagnosis UC 0.295880836386666 0.423003743815724 803 791 0.484501240372217 0.754283346704648 -THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III diagnosis CD -0.582220677956505 0.832836455393384 803 682 0.484746916391146 0.754283346704648 -PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II dysbiosisUC Yes 0.0828462350649265 0.118543430033296 803 798 0.484880213567441 0.754283346704648 -RIBOSYN2_PWY_flavin_biosyn_I dysbiosisUC Yes -0.497693492972006 0.712124866669811 803 478 0.484896437167274 0.754283346704648 -PWY_7400_L_arginine_biosyn_IV diagnosis CD 0.730719444163606 1.05140411212656 803 495 0.487310578559597 0.755835632411365 -PWY_2942_L_lysine_biosyn_III antibiotics Yes -0.0524068536441909 0.0754986615136958 803 802 0.487836159340887 0.755835632411365 -DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I age age 0.218096269311305 0.314376340133 803 790 0.488087340550417 0.755835632411365 -COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn antibiotics Yes 0.127896347645076 0.184468044089109 803 773 0.488349021401116 0.755835632411365 -P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate dysbiosisnonIBD Yes 0.692693665584671 1.00413998744813 803 283 0.490555181918646 0.755835632411365 -PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I diagnosis UC 0.355526735572747 0.516371158370795 803 783 0.49137284241469 0.755835632411365 -RHAMCAT_PWY_L_rhamnose_deg_I dysbiosisUC Yes 0.374920360060182 0.545502622949906 803 709 0.49213928227308 0.755835632411365 -PWY_6163_chorismate_biosyn_from_3_dehydroquinate diagnosis CD -0.371290994175403 0.540275827054506 803 787 0.492182064561087 0.755835632411365 -PWY4FS_7_phosphatidylglycerol_biosyn_I diagnosis CD 0.952461902907466 1.38780799540422 803 604 0.492762233234944 0.755835632411365 -PWY4FS_8_phosphatidylglycerol_biosyn_II diagnosis CD 0.952462042840151 1.38780802998488 803 604 0.492762180481458 0.755835632411365 -PWY_6124_inosine_5_phosphate_biosyn_II dysbiosisUC Yes -0.172909447299816 0.252202299822348 803 792 0.493206516488108 0.755835632411365 -MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn dysbiosisCD Yes 0.367171072396954 0.5362871277314 803 375 0.493806394123581 0.755835632411365 -CALVIN_PWY_Calvin_Benson_Bassham_cyc antibiotics Yes -0.0769257210685253 0.112620687207005 803 797 0.494813676987703 0.755835632411365 -PWY_7237_myo__chiro__scillo_inositol_deg age age 0.837373192589701 1.2268498325546 803 441 0.495146926439934 0.755835632411365 -PWY_7187_pyrimidine_dnt_de_novo_biosyn_II dysbiosisnonIBD Yes -0.413375890373599 0.606186765785929 803 647 0.495523905329194 0.755835632411365 -PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I antibiotics Yes 0.0426231759465704 0.0625151084313753 803 799 0.495600089630887 0.755835632411365 -PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I dysbiosisUC Yes 0.0638048045380298 0.0945820364698779 803 799 0.500167039346483 0.761868130838286 -PWY_7400_L_arginine_biosyn_IV antibiotics Yes 0.254719292030879 0.379525945723633 803 495 0.502365611585637 0.764282725318319 -ARGSYN_PWY_L_arginine_biosyn_I antibiotics Yes 0.258568905889451 0.386788859860743 803 495 0.504053849777768 0.764496785365518 -PWY_6168_flavin_biosyn_III dysbiosisnonIBD Yes 0.219395995294199 0.328395810161996 803 760 0.50431351545398 0.764496785365518 -SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I diagnosis CD 0.50880329855612 0.763926920762861 803 767 0.505619716248971 0.764496785365518 -PWY_6282_palmitoleate_biosyn_I dysbiosisnonIBD Yes 0.548708363962409 0.825177314959284 803 531 0.506337544314713 0.764496785365518 -PWY_7560_methylerythritol_phosphate_pwy_II dysbiosisUC Yes -0.439481427422688 0.661415508392311 803 226 0.506702454760401 0.764496785365518 -ARGSYN_PWY_L_arginine_biosyn_I diagnosis CD 0.711597693357645 1.07194506012812 803 495 0.507032423011147 0.764496785365518 -PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II dysbiosisUC Yes 0.230257245433189 0.347319485999467 803 769 0.507590033712874 0.764496785365518 -PWY0_1297_SP_of_purine_dns_deg dysbiosisUC Yes 0.4301244255574 0.648866831244318 803 610 0.507636012542999 0.764496785365518 -FUCCAT_PWY_fucose_deg antibiotics Yes -0.422389179280872 0.637700745017448 803 268 0.508028361382543 0.764496785365518 -PWY_6897_thiamin_salvage_II age age 0.512538600638522 0.776368773672582 803 589 0.509372049844435 0.765594178656413 -NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I dysbiosisUC Yes -0.0935990398516156 0.142504793878741 803 799 0.511529249349682 0.767023478900311 -PWY66_422_D_galactose_deg_V dysbiosisUC Yes -0.204416994514832 0.311243816490377 803 785 0.511554182155825 0.767023478900311 -PWY_7388_octanoyl_acyl_carrier_protein_biosyn diagnosis CD -0.834736309844652 1.27572072160897 803 535 0.513157669983158 0.768066892777039 -PWY0_1297_SP_of_purine_dns_deg dysbiosisnonIBD Yes 0.452179733752996 0.69243571748278 803 610 0.51396649065643 0.768066892777039 -PWY_5913_TCA_cyc_VI dysbiosisnonIBD Yes 0.685205587891115 1.05117741147544 803 146 0.514942333302458 0.768066892777039 -PWY_5347_SP_of_L_methionine_biosyn dysbiosisCD Yes 0.326935030205343 0.501978381646995 803 373 0.515087520950978 0.768066892777039 -ARO_PWY_chorismate_biosyn_I antibiotics Yes 0.127796749296184 0.196336175333473 803 775 0.515332200932267 0.768066892777039 -PWY_5484_glycolysis_II dysbiosisCD Yes -0.109944672127989 0.169323450765851 803 791 0.516359099461662 0.768164016491343 -PWY_7219_adenosine_rnt_de_novo_biosyn dysbiosisnonIBD Yes 0.0749614481426449 0.115521440164158 803 803 0.516630373852123 0.768164016491343 -PWY0_1586_peptidoglycan_maturation dysbiosisUC Yes -0.308860063212032 0.478973587771169 803 773 0.519256319458022 0.770225779688341 -GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg age age -0.39277862523038 0.611289248818707 803 745 0.520745217021176 0.770225779688341 -PWY_7219_adenosine_rnt_de_novo_biosyn dysbiosisCD Yes 0.0484995629329411 0.0756389041105065 803 803 0.521615545425846 0.770225779688341 -DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II dysbiosisUC Yes 0.327320710461337 0.510615784624113 803 614 0.521725870787913 0.770225779688341 -PWY4FS_7_phosphatidylglycerol_biosyn_I dysbiosisUC Yes 0.497632661746137 0.77832657592978 803 604 0.522810469604857 0.770225779688341 -PWY4FS_8_phosphatidylglycerol_biosyn_II dysbiosisUC Yes 0.497632196563822 0.778326596725461 803 604 0.522810869182361 0.770225779688341 -COA_PWY_1_coenzyme_A_biosyn_II antibiotics Yes 0.059240128524919 0.0926861437500914 803 800 0.522947986452055 0.770225779688341 -PWY_5659_GDP_mannose_biosyn age age 0.284742942152071 0.445519161893807 803 788 0.522962287011506 0.770225779688341 -FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation diagnosis CD -0.803213617486711 1.26044630920843 803 539 0.524212199466535 0.770605930747095 -P105_PWY_TCA_cyc_IV dysbiosisnonIBD Yes 0.566438695836186 0.888771074350678 803 101 0.524457326864797 0.770605930747095 -DAPLYSINESYN_PWY_L_lysine_biosyn_I antibiotics Yes -0.209875440891139 0.332665007430462 803 595 0.528335812447909 0.775390367856413 -PWY_7664_oleate_biosyn_IV dysbiosisnonIBD Yes 0.514376476295783 0.817238885543718 803 531 0.529326203784338 0.775671623318585 -PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine diagnosis UC 0.683011339452076 1.08641274074727 803 597 0.529772513197525 0.775671623318585 -PWY_6527_stachyose_deg diagnosis UC 0.453967231216472 0.724284320792484 803 766 0.531019262590446 0.775987379661315 -PWY_7234_inosine_5_phosphate_biosyn_III dysbiosisCD Yes -0.246584020973817 0.393612831001293 803 690 0.531233735835555 0.775987379661315 -PWY_6936_seleno_amino_acid_biosyn diagnosis UC -0.879253128797823 1.40662831702761 803 472 0.532135909698915 0.77639501579022 -VALSYN_PWY_L_valine_biosyn diagnosis CD 0.194307527668123 0.311706256138541 803 802 0.533257802117681 0.777121896419451 -PWY_5695_urate_biosyn_inosine_5_phosphate_deg dysbiosisnonIBD Yes 0.107482659711502 0.173620989233769 803 800 0.536086579395878 0.780331633092598 -P161_PWY_acetylene_deg dysbiosisUC Yes -0.424395037680104 0.687578784722235 803 537 0.53729876186189 0.781183497409469 -METSYN_PWY_L_homoserine__L_methionine_biosyn dysbiosisCD Yes 0.315532142192847 0.513690382209859 803 375 0.539267862444861 0.781971017222888 -RHAMCAT_PWY_L_rhamnose_deg_I age age 0.467376537801246 0.761435330795742 803 709 0.539552456052657 0.781971017222888 -ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn diagnosis UC 0.78669721860221 1.28215129010617 803 732 0.539723174006167 0.781971017222888 -P161_PWY_acetylene_deg dysbiosisnonIBD Yes 0.44969600807861 0.734436122012305 803 537 0.540553056716702 0.782263773134739 -PWY_7400_L_arginine_biosyn_IV dysbiosisnonIBD Yes 0.391006983727053 0.642220667851965 803 495 0.542848594142685 0.783395353415292 -PWY0_862_dodec_5_enoate_biosyn diagnosis UC -0.783273681701877 1.28735992766028 803 546 0.54313257373906 0.783395353415292 -PWY_6124_inosine_5_phosphate_biosyn_II age age 0.211150764205103 0.348385852409099 803 792 0.544667352561203 0.783395353415292 -PWY66_422_D_galactose_deg_V dysbiosisCD Yes -0.143490557473131 0.236792144819574 803 785 0.544737839534761 0.783395353415292 -PWY_3001_SP_of_L_isoleucine_biosyn_I antibiotics Yes -0.0841187428764582 0.138899999521131 803 782 0.544983647118881 0.783395353415292 -PWY_5973_cis_vaccenate_biosyn age age -0.228154145256763 0.377479810559861 803 787 0.54577540488397 0.783395353415292 -PWY_3001_SP_of_L_isoleucine_biosyn_I diagnosis CD 0.241825727095227 0.400185274584543 803 782 0.545861595585585 0.783395353415292 -PWY_7456_mannan_deg dysbiosisCD Yes -0.309265455386493 0.512292324447821 803 210 0.54636481710906 0.783395353415292 -PENTOSE_P_PWY_pentose_phosphate_pwy dysbiosisCD Yes 0.26856308398474 0.447121278410486 803 613 0.548284587522081 0.78524436327875 -PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I diagnosis UC -0.104063045715273 0.173753726377307 803 799 0.549437011909652 0.785413589185241 -PWY_7184_pyrimidine_dnt_de_novo_biosyn_I diagnosis CD 0.424680277839645 0.709759671989089 803 747 0.549815852486809 0.785413589185241 -PWY_5101_L_isoleucine_biosyn_II dysbiosisUC Yes -0.34081196239635 0.572237189463704 803 574 0.551677979277639 0.785413589185241 -PWY_6270_isoprene_biosyn_I dysbiosisUC Yes -0.394998601035891 0.663791933169523 803 219 0.552071060854122 0.785413589185241 -PWY_6703_preQ0_biosyn age age 0.325297856209154 0.546078534115711 803 771 0.551580634772258 0.785413589185241 -PWY_5103_L_isoleucine_biosyn_III antibiotics Yes -0.128000475161574 0.215201582577894 803 778 0.552184834772288 0.785413589185241 -PWY_5971_palmitate_biosyn_II age age -0.690968050279803 1.16343028286182 803 143 0.552851415155798 0.785465066458523 -PWY_5100_pyruvate_fermentation_to_acetate__lactate_II antibiotics Yes 0.147100881100967 0.248129882597248 803 778 0.553492180741554 0.785479791804073 -NAGLIPASYN_PWY_lipid_IVA_biosyn age age -0.532773843772191 0.901510717907462 803 601 0.554750258702163 0.78583039222314 -PWY_7184_pyrimidine_dnt_de_novo_biosyn_I dysbiosisnonIBD Yes -0.251150407101369 0.426248427360169 803 747 0.555921129919351 0.78583039222314 -PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn dysbiosisUC Yes 0.19619717735688 0.333116366953944 803 761 0.556079639013459 0.78583039222314 -PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I dysbiosisCD Yes 0.11796416254516 0.200431678607793 803 792 0.556363601712291 0.78583039222314 -PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine dysbiosisUC Yes -0.346618297132238 0.589725383228999 803 597 0.556892645532129 0.78583039222314 -NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I diagnosis CD -0.155620929733466 0.2659023702466 803 799 0.558575101108328 0.78691685341472 -ARGSYN_PWY_L_arginine_biosyn_I dysbiosisnonIBD Yes 0.382835703431102 0.654707166891026 803 495 0.558925694439829 0.78691685341472 -ILEUSYN_PWY_L_isoleucine_biosyn_I dysbiosisUC Yes 0.135687308544362 0.232836755737685 803 773 0.560255165622084 0.787898348041892 -GLYCOGENSYNTH_PWY_glycogen_biosyn_I diagnosis UC -0.634114442249258 1.09785567500601 803 706 0.563735198147887 0.790070371724546 -COA_PWY_coenzyme_A_biosyn_I diagnosis UC -0.398514100342438 0.690772701925757 803 774 0.564195963527339 0.790070371724546 -PWY_6122_5_aminoimidazole_rnt_biosyn_II diagnosis CD -0.183780348960275 0.318674034563867 803 799 0.564335979803247 0.790070371724546 -PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn diagnosis CD -0.183780348960275 0.318674034563867 803 799 0.564335979803247 0.790070371724546 -PWY_2942_L_lysine_biosyn_III age age 0.0957555551362055 0.167072819664282 803 802 0.566746802759223 0.792555012612785 -FASYN_ELONG_PWY_fatty_acid_elongation__saturated dysbiosisnonIBD Yes 0.463148867317782 0.810347653497972 803 532 0.56784936895174 0.793206629724067 -PWY_7383_anaerobic_energy_metabolism dysbiosisUC Yes -0.404098987319514 0.709184914618257 803 698 0.569017950594713 0.79394889859016 -TRNA_CHARGING_PWY_tRNA_charging antibiotics Yes 0.192124632749764 0.33871349768985 803 703 0.570759346619734 0.795487858935334 -VALSYN_PWY_L_valine_biosyn antibiotics Yes -0.0612578103142138 0.10826565642442 803 802 0.571714555664872 0.795928867439587 -PWY_4041_beta_glutamyl_cyc antibiotics Yes 0.437407000656062 0.778234601048317 803 247 0.574478928935321 0.798204394038054 -FUCCAT_PWY_fucose_deg diagnosis CD -0.868750440476602 1.54952718619457 803 268 0.575270903568357 0.798204394038054 -PWY_7199_pyrimidine_dns_salvage diagnosis UC 0.617448514556937 1.10098881520346 803 694 0.575115270831187 0.798204394038054 -P441_PWY_SP_of_N_acetylneuraminate_deg antibiotics Yes 0.287921303085651 0.515143812628368 803 433 0.576412334708749 0.798898519518466 -GALACTUROCAT_PWY_D_galacturonate_deg_I age age 0.272412667501698 0.490880170727979 803 776 0.579118100533574 0.799304634524349 -PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I dysbiosisUC Yes -0.197350888442178 0.355552117661637 803 762 0.579044712551805 0.799304634524349 -PWY_5659_GDP_mannose_biosyn antibiotics Yes -0.112606350406721 0.202968751169769 803 788 0.579221545193471 0.799304634524349 -P105_PWY_TCA_cyc_IV diagnosis UC -0.863323627463428 1.55878480579012 803 101 0.580149130288743 0.799304634524349 -PWY_6123_inosine_5_phosphate_biosyn_I dysbiosisnonIBD Yes 0.122951057457432 0.222194979411678 803 794 0.58021223967247 0.799304634524349 -PWY_7208_SP_of_pyrimidine_nucleobases_salvage antibiotics Yes -0.0840132282835859 0.152072381100711 803 794 0.580822765998911 0.799304634524349 -SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I dysbiosisnonIBD Yes -0.257635712554843 0.466806916826526 803 767 0.581195825745634 0.799304634524349 -PWY0_1297_SP_of_purine_dns_deg age age -0.47669237237893 0.874107831745538 803 610 0.585699463360298 0.804610288144356 -DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II age age -0.379945562527452 0.704737273482871 803 614 0.589979253200622 0.809597080933893 -BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn antibiotics Yes -0.114879416351752 0.21371952350819 803 773 0.591086207799097 0.810223778787321 -PWY_6936_seleno_amino_acid_biosyn antibiotics Yes -0.267815647234212 0.499480120708812 803 472 0.59200900792042 0.810596949306421 -TCA_TCA_cyc_I dysbiosisUC Yes -0.389358970723222 0.728290621138097 803 412 0.593115550260132 0.811220609905735 -DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II dysbiosisnonIBD Yes 0.30002498653938 0.563495351011901 803 614 0.594604347901405 0.811475375120647 -RIBOSYN2_PWY_flavin_biosyn_I diagnosis UC -0.589043291189895 1.10534083085517 803 478 0.594296957451595 0.811475375120647 -PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I diagnosis UC -0.667046391103057 1.25546809187828 803 561 0.59538403778267 0.811650449756244 -PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg dysbiosisCD Yes -0.179712759765842 0.340098836024919 803 757 0.597390115902352 0.813495174223312 -GALACTUROCAT_PWY_D_galacturonate_deg_I antibiotics Yes 0.116033728211054 0.222011541602722 803 776 0.601394594000636 0.818054218476848 -PWY_7196_SP_of_pyrimidine_rns_salvage diagnosis CD 0.633613942621903 1.21801345552554 803 411 0.603108870379845 0.819491442195515 -TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA diagnosis UC 0.755457420679534 1.46180183096479 803 159 0.605663930632544 0.822066729377069 -GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff antibiotics Yes -0.247646682411152 0.480794580755921 803 412 0.606682735664936 0.822553524089783 -PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisnonIBD Yes -0.206262425483227 0.401345670405691 803 742 0.607474960455231 0.822732392094802 -ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn dysbiosisCD Yes -0.133639615329238 0.260856539601115 803 732 0.608618057304699 0.823024729265973 -COA_PWY_1_coenzyme_A_biosyn_II dysbiosisnonIBD Yes -0.0826892810655329 0.161588273940974 803 800 0.609011878317197 0.823024729265973 -PWY_4242_pantothenate__coenzyme_A_biosyn_III antibiotics Yes -0.178122267732545 0.350339851356719 803 725 0.611323248042148 0.825253268754622 -PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II diagnosis CD 0.149473186900669 0.296260210230335 803 794 0.614054449711493 0.82804312158065 -DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II diagnosis CD -0.455719020086464 0.911873535044429 803 614 0.617410555100656 0.830141056390338 -PWY_3841_folate_transformations_II dysbiosisUC Yes -0.114371925931635 0.228819750116593 803 787 0.617357952153843 0.830141056390338 -FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation dysbiosisnonIBD Yes -0.399998428690321 0.802500132302147 803 539 0.618359476528101 0.830141056390338 -PWY_2941_L_lysine_biosyn_II dysbiosisCD Yes 0.23465956348022 0.471501035200418 803 454 0.618895499919103 0.830141056390338 -BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn dysbiosisUC Yes -0.168129058035057 0.337889773078901 803 773 0.618941445735653 0.830141056390338 -PWY_7400_L_arginine_biosyn_IV diagnosis UC 0.517354220117697 1.04964623802647 803 495 0.6222628266258 0.833698367715857 -PWY_6123_inosine_5_phosphate_biosyn_I age age 0.137126018496448 0.27978335044598 803 794 0.624214908032446 0.834248209196176 -PENTOSE_P_PWY_pentose_phosphate_pwy dysbiosisnonIBD Yes -0.328532840640421 0.67098990740928 803 613 0.624566383294722 0.834248209196176 -GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg age age -0.286845128811108 0.586050226237434 803 755 0.624681845248822 0.834248209196176 -P105_PWY_TCA_cyc_IV dysbiosisCD Yes 0.27112253643632 0.556090431927057 803 101 0.626267868691698 0.835470839817833 -PWY_3841_folate_transformations_II antibiotics Yes -0.0706678228272712 0.146945678695069 803 787 0.630738510700447 0.836040222102163 -PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn diagnosis CD 0.317870634512521 0.661457736878554 803 742 0.630987955601007 0.836040222102163 -PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II diagnosis UC -0.141671376368767 0.29606454167951 803 794 0.632441569023651 0.836040222102163 -PWY_7388_octanoyl_acyl_carrier_protein_biosyn dysbiosisnonIBD Yes -0.388634233985817 0.812257794952676 803 535 0.632499185562007 0.836040222102163 -MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn dysbiosisUC Yes -0.354598928320186 0.742079221719529 803 375 0.632921102928466 0.836040222102163 -PWY66_399_gluconeogenesis_III dysbiosisCD Yes -0.276108825171369 0.57774307610568 803 670 0.63288762832847 0.836040222102163 -UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I age age -0.440617972733203 0.921588960512088 803 503 0.632742161616501 0.836040222102163 -PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I dysbiosisnonIBD Yes 0.144055054539953 0.302778619500349 803 792 0.634390332643946 0.836040222102163 -PWY_6168_flavin_biosyn_III age age -0.19749602162266 0.415215527072474 803 760 0.634483269399898 0.836040222102163 -PWY_7196_SP_of_pyrimidine_rns_salvage diagnosis UC 0.551473731837604 1.15975683660481 803 411 0.634593181463061 0.836040222102163 -PWY_5723_Rubisco_shunt diagnosis UC -0.944539300919849 1.98735409337902 803 212 0.63491946865153 0.836040222102163 -PWY0_862_dodec_5_enoate_biosyn diagnosis CD -0.607541079119617 1.2812528854399 803 546 0.635548000940171 0.836040222102163 -ARGSYN_PWY_L_arginine_biosyn_I diagnosis UC 0.50591576059331 1.070250253033 803 495 0.636582239665049 0.836040222102163 -PWY_6385_peptidoglycan_biosyn_III dysbiosisnonIBD Yes -0.0722783185946782 0.153663027483099 803 797 0.638246361140491 0.836040222102163 -PWY_7383_anaerobic_energy_metabolism antibiotics Yes -0.210156310699024 0.446955638473629 803 698 0.638383756983553 0.836040222102163 -PWY_4242_pantothenate__coenzyme_A_biosyn_III dysbiosisUC Yes 0.258844336869461 0.552203791258426 803 725 0.639404200209268 0.836040222102163 -PWY_6969_TCA_cyc_V dysbiosisCD Yes 0.239193355819373 0.510890834619617 803 403 0.639824279941521 0.836040222102163 -GLYCOGENSYNTH_PWY_glycogen_biosyn_I diagnosis CD -0.526702720675794 1.12828726760049 803 706 0.640785242461931 0.836040222102163 -PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I dysbiosisnonIBD Yes 0.0494922386517645 0.10594062731003 803 799 0.640532277966424 0.836040222102163 -PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn diagnosis CD -0.551884913437474 1.1808468530281 803 281 0.640407166768099 0.836040222102163 -PWY_5104_L_isoleucine_biosyn_IV dysbiosisCD Yes 0.316202454634235 0.67690704465634 803 475 0.640568564540998 0.836040222102163 -PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage dysbiosisnonIBD Yes -0.202677790315675 0.435731584173258 803 754 0.641983881237422 0.836488832870724 -PWY_5989_stearate_biosyn_II antibiotics Yes -0.207161935427374 0.44602517282401 803 575 0.642471760078076 0.836488832870724 -PWY_2941_L_lysine_biosyn_II dysbiosisnonIBD Yes 0.315732921677586 0.683979367363053 803 454 0.644534338296424 0.838298314736268 -PWY66_422_D_galactose_deg_V dysbiosisnonIBD Yes 0.162094860177238 0.352548514607521 803 785 0.645824886378198 0.838367520460442 -PWY_6123_inosine_5_phosphate_biosyn_I dysbiosisUC Yes 0.092384317502831 0.201108117685852 803 794 0.64611472002856 0.838367520460442 -SALVADEHYPOX_PWY_adenosine_nt_deg_II diagnosis UC 0.555340026130994 1.21180887164549 803 638 0.646908349417147 0.838367520460442 -PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I diagnosis UC 0.373760434063804 0.817750222445651 803 764 0.647778741238521 0.838367520460442 -MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn dysbiosisnonIBD Yes -0.370926820245079 0.811972747302495 803 375 0.647951783469828 0.838367520460442 -PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III antibiotics Yes -0.190963977465428 0.419588586948065 803 512 0.649174657594983 0.839078447472354 -METSYN_PWY_L_homoserine__L_methionine_biosyn dysbiosisnonIBD Yes -0.352601156459386 0.777583229061515 803 375 0.650370490228284 0.839752985310302 -THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III antibiotics Yes -0.132592416667842 0.293311781781335 803 682 0.651379237378625 0.839883659010211 -PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II antibiotics Yes -0.0964055903096328 0.214452600834845 803 783 0.653187395334032 0.839883659010211 -GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg dysbiosisUC Yes -0.42329465807949 0.942624700980598 803 300 0.653617029990213 0.839883659010211 -NAGLIPASYN_PWY_lipid_IVA_biosyn dysbiosisUC Yes -0.286866275006771 0.639619670332426 803 601 0.653952886243191 0.839883659010211 -PWY_5104_L_isoleucine_biosyn_IV dysbiosisUC Yes 0.395980415693369 0.884293325414346 803 475 0.654455516733587 0.839883659010211 -X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn dysbiosisUC Yes -0.130381999818275 0.291442702863864 803 779 0.654756060994538 0.839883659010211 -PWY_5177_glutaryl_CoA_deg dysbiosisnonIBD Yes -0.232374509167599 0.521906225378741 803 753 0.65629297476141 0.839883659010211 -PWY_6737_starch_deg_V dysbiosisnonIBD Yes 0.137077287101877 0.30825790294244 803 800 0.656693643488402 0.839883659010211 -SALVADEHYPOX_PWY_adenosine_nt_deg_II antibiotics Yes -0.19071838237996 0.430518859715507 803 638 0.657914923892277 0.839883659010211 -PWY_7220_adenosine_dnt_de_novo_biosyn_II antibiotics Yes -0.101123801682952 0.228628815546793 803 783 0.658412556727199 0.839883659010211 -PWY_7222_guanosine_dnt_de_novo_biosyn_II antibiotics Yes -0.101123801682952 0.228628815546793 803 783 0.658412556727199 0.839883659010211 -PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II dysbiosisnonIBD Yes 0.1647022126143 0.372544253695667 803 783 0.658560461358729 0.839883659010211 -ARGSYNBSUB_PWY_L_arginine_biosyn_II antibiotics Yes 0.266268095298494 0.605382534936963 803 428 0.660208577882561 0.841124629899459 -METSYN_PWY_L_homoserine__L_methionine_biosyn dysbiosisUC Yes -0.311103597045882 0.710287927086329 803 375 0.661534362515288 0.841509763129161 -PWY_5097_L_lysine_biosyn_VI dysbiosisUC Yes -0.0587066010025467 0.134173881376801 803 802 0.661861611449902 0.841509763129161 -PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I antibiotics Yes -0.0759578876187417 0.174166823179966 803 792 0.662890798922137 0.841615575902499 -P108_PWY_pyruvate_fermentation_to_propanoate_I diagnosis CD 1.15807110272229 2.66544127422558 803 350 0.664174551052682 0.841615575902499 -PWY_5347_SP_of_L_methionine_biosyn dysbiosisUC Yes -0.299979369914233 0.694134723383511 803 373 0.665766248504231 0.841615575902499 -PWY0_1479_tRNA_processing diagnosis CD 0.510591827936229 1.18199095403752 803 414 0.665958168384187 0.841615575902499 -TCA_TCA_cyc_I age age -0.41011913532529 0.950861989288181 803 412 0.666399694787299 0.841615575902499 -ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn antibiotics Yes -0.0550439665909944 0.127964463105597 803 797 0.667226432363358 0.841615575902499 -PWY_7111_pyruvate_fermentation_to_isobutanol dysbiosisCD Yes 0.0530360096930412 0.123610279390615 803 801 0.668020426652344 0.841615575902499 -PWY_6897_thiamin_salvage_II diagnosis UC 0.439735251379999 1.02727777754277 803 589 0.668747774624942 0.841615575902499 -ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn antibiotics Yes -0.0857965606215298 0.200815469353649 803 732 0.669353976968673 0.841615575902499 -PWY_6282_palmitoleate_biosyn_I diagnosis CD 0.555597032006233 1.30134482168793 803 531 0.669578554869792 0.841615575902499 -PWY_7242_D_fructuronate_deg age age -0.197995497428863 0.463713143224074 803 773 0.669533885676894 0.841615575902499 -GALACTUROCAT_PWY_D_galacturonate_deg_I dysbiosisCD Yes 0.111577025026435 0.26196910921096 803 776 0.670306966462888 0.841615575902499 -PWY_6353_purine_nt_deg_II dysbiosisUC Yes -0.311613694229183 0.732606091425124 803 432 0.670725735851671 0.841615575902499 -RIBOSYN2_PWY_flavin_biosyn_I dysbiosisnonIBD Yes 0.287970713108572 0.678936049285394 803 478 0.671609484090152 0.841876677239768 -PWY_6151_S_adenosyl_L_methionine_cyc_I dysbiosisUC Yes 0.0901578314888356 0.213174914326495 803 791 0.672484485270098 0.842126300147278 -RHAMCAT_PWY_L_rhamnose_deg_I diagnosis CD 0.41049557464441 0.977583696241484 803 709 0.674689051988757 0.843389964108221 -METSYN_PWY_L_homoserine__L_methionine_biosyn age age 0.412122098743271 0.981957423573908 803 375 0.674847346882742 0.843389964108221 -PWY_6545_pyrimidine_dnt_de_novo_biosyn_III age age -0.270955206084334 0.648506363302239 803 651 0.676219022945089 0.84425741742443 -GLYOXYLATE_BYPASS_glyoxylate_cyc antibiotics Yes -0.396509177474178 0.951963641836872 803 255 0.677273795920049 0.844461365373513 -TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA dysbiosisUC Yes -0.376877172123711 0.906076717312607 803 159 0.677737853429786 0.844461365373513 -PWY_5101_L_isoleucine_biosyn_II dysbiosisCD Yes -0.181164788976973 0.441450664159546 803 574 0.68166755195025 0.848299560251772 -GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg diagnosis UC -0.305019844897523 0.74454797676029 803 757 0.682179903188022 0.848299560251772 -PWY0_1479_tRNA_processing dysbiosisnonIBD Yes -0.337308622124047 0.828042184505611 803 414 0.683932602486894 0.848310539556934 -PWY_7197_pyrimidine_dnt_phosphorylation dysbiosisUC Yes -0.171620708381308 0.422463265810166 803 751 0.68469928429939 0.848310539556934 -PWY_7220_adenosine_dnt_de_novo_biosyn_II dysbiosisnonIBD Yes 0.160525265145343 0.396343442884123 803 783 0.685596908449721 0.848310539556934 -PWY_7222_guanosine_dnt_de_novo_biosyn_II dysbiosisnonIBD Yes 0.160525265145343 0.396343442884123 803 783 0.685596908449721 0.848310539556934 -GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg dysbiosisnonIBD Yes -0.187976826968783 0.464630027944913 803 755 0.685921991378756 0.848310539556934 -PWY_7111_pyruvate_fermentation_to_isobutanol age age -0.0961741823544275 0.238239327006499 803 801 0.686573067843571 0.848310539556934 -PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn age age -0.406762725092487 1.01801960841088 803 281 0.689618909173351 0.848310539556934 -PWY_5188_tetrapyrrole_biosyn_I dysbiosisUC Yes -0.199074815146987 0.499876791959613 803 731 0.69057635249581 0.848310539556934 -GLYOXYLATE_BYPASS_glyoxylate_cyc diagnosis UC 0.861522392143745 2.17643961306007 803 255 0.692451654051704 0.848310539556934 -PWY_5347_SP_of_L_methionine_biosyn age age 0.379228576050234 0.959021243890589 803 373 0.692653157364882 0.848310539556934 -OANTIGEN_PWY_O_antigen_building_blocks_biosyn dysbiosisnonIBD Yes 0.246979634006398 0.627669540497054 803 445 0.694095517452858 0.848310539556934 -PWY_6122_5_aminoimidazole_rnt_biosyn_II dysbiosisCD Yes -0.0514943198267324 0.130873605436093 803 799 0.694101985213069 0.848310539556934 -PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn dysbiosisCD Yes -0.0514943198267324 0.130873605436093 803 799 0.694101985213069 0.848310539556934 -P161_PWY_acetylene_deg antibiotics Yes 0.165008326298966 0.421316775775312 803 537 0.6954460806351 0.848310539556934 -PWY_7383_anaerobic_energy_metabolism dysbiosisnonIBD Yes 0.280758219157552 0.716954665429634 803 698 0.695491811070912 0.848310539556934 -PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I dysbiosisUC Yes 0.0382009639456463 0.097647315252176 803 799 0.695765189341899 0.848310539556934 -PWY_6703_preQ0_biosyn diagnosis UC -0.288471982884206 0.739049577540054 803 771 0.696419344744576 0.848310539556934 -BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn age age 0.183718584592039 0.470996825091173 803 773 0.69661519466524 0.848310539556934 -ANAEROFRUCAT_PWY_homolactic_fermentation dysbiosisCD Yes 0.0997757330587815 0.25608182393928 803 770 0.696939980265059 0.848310539556934 -PWY_6124_inosine_5_phosphate_biosyn_II diagnosis CD -0.174715022224296 0.449421380938955 803 792 0.697582041868475 0.848310539556934 -PWY_7237_myo__chiro__scillo_inositol_deg dysbiosisUC Yes 0.329294069417912 0.847374758361123 803 441 0.697698624768452 0.848310539556934 -DAPLYSINESYN_PWY_L_lysine_biosyn_I dysbiosisUC Yes -0.21094249406775 0.543924670964281 803 595 0.698280818953299 0.848310539556934 -PWY_5103_L_isoleucine_biosyn_III age age 0.183791174811355 0.474543266480664 803 778 0.698657721322928 0.848310539556934 -PWY_6385_peptidoglycan_biosyn_III age age -0.07540009582388 0.194840120680587 803 797 0.698892092427252 0.848310539556934 -PWY_7187_pyrimidine_dnt_de_novo_biosyn_II diagnosis UC 0.377171733758889 0.975722345510708 803 647 0.699209409410089 0.848310539556934 -TRNA_CHARGING_PWY_tRNA_charging age age 0.278990323387494 0.732222205168301 803 703 0.703312575408086 0.850644487305286 -GLYCOLYSIS_glycolysis_I diagnosis UC 0.160037095642782 0.420092314642845 803 791 0.703357768763917 0.850644487305286 -PWY_7663_gondoate_biosyn dysbiosisUC Yes 0.101739239459464 0.267453161134363 803 792 0.703770379534154 0.850644487305286 -PWY_3001_SP_of_L_isoleucine_biosyn_I dysbiosisnonIBD Yes -0.0930135985908379 0.244596197092403 803 782 0.703863937730136 0.850644487305286 -PWY_6124_inosine_5_phosphate_biosyn_II dysbiosisnonIBD Yes 0.104785146949453 0.276673622982994 803 792 0.705008338770885 0.850653214974672 -PWY_2942_L_lysine_biosyn_III dysbiosisUC Yes -0.0445658612849773 0.117766842342751 803 802 0.705236573891522 0.850653214974672 -FASYN_ELONG_PWY_fatty_acid_elongation__saturated diagnosis UC 0.480776362380413 1.27988485979049 803 532 0.707319553177895 0.85152186625316 -PWY_7664_oleate_biosyn_IV diagnosis CD 0.483920147167543 1.28898229151516 803 531 0.707477284262099 0.85152186625316 -PWY_5723_Rubisco_shunt dysbiosisUC Yes 0.372245791343831 0.995734719973192 803 212 0.708773813933291 0.85152186625316 -PWY_6163_chorismate_biosyn_from_3_dehydroquinate dysbiosisUC Yes -0.110201531592026 0.294987556979097 803 787 0.708836399201658 0.85152186625316 -TRNA_CHARGING_PWY_tRNA_charging dysbiosisnonIBD Yes -0.217054287336551 0.582135263084601 803 703 0.70937375374862 0.85152186625316 -PWY_6901_SP_of_glucose__xylose_deg dysbiosisnonIBD Yes -0.232723583726392 0.62590817889228 803 436 0.710161815732077 0.851647374785532 -ARGSYN_PWY_L_arginine_biosyn_I dysbiosisUC Yes -0.223045063106786 0.601887556218446 803 495 0.71107561936525 0.851870747748113 -PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I diagnosis UC 0.510832078432921 1.38425153510537 803 557 0.71222442000233 0.851870747748113 -PWY_6936_seleno_amino_acid_biosyn dysbiosisnonIBD Yes -0.319481032825718 0.866284000405006 803 472 0.712399132546977 0.851870747748113 -MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn age age 0.37532902165072 1.02486030194056 803 375 0.71431667797064 0.853344756233382 -PWY0_1586_peptidoglycan_maturation age age -0.23650051187122 0.66030828887176 803 773 0.720332834995049 0.859707578930873 -SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I diagnosis UC 0.27096633789109 0.758532223437997 803 767 0.72103754975377 0.859725155017414 -PWY_5347_SP_of_L_methionine_biosyn antibiotics Yes -0.158661293720727 0.451934026448573 803 373 0.725648239280645 0.864395512565663 -COA_PWY_coenzyme_A_biosyn_I dysbiosisnonIBD Yes -0.146792457496107 0.420195518401666 803 774 0.726942745567347 0.864489708016616 -PWY_7383_anaerobic_energy_metabolism dysbiosisCD Yes -0.183149838342129 0.524594722257397 803 698 0.72711493900595 0.864489708016616 -PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I diagnosis CD 0.179286623127702 0.516522519002431 803 783 0.728624098360069 0.865458175935792 -PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I dysbiosisnonIBD Yes -0.294873746173736 0.852931363756935 803 557 0.729666325306737 0.865870706030661 -PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisUC Yes 0.1914438332916 0.557985958057142 803 469 0.731635884511941 0.867381838346221 -PWY_6353_purine_nt_deg_II age age -0.337242933467923 0.991396781264989 803 432 0.733841214436388 0.868863799736187 -PWY_5100_pyruvate_fermentation_to_acetate__lactate_II dysbiosisUC Yes 0.130175014712607 0.38438933231817 803 778 0.734977885170097 0.868863799736187 -PWY_7197_pyrimidine_dnt_phosphorylation diagnosis CD -0.257932514041259 0.761170189807968 803 751 0.734820621124663 0.868863799736187 -METSYN_PWY_L_homoserine__L_methionine_biosyn antibiotics Yes -0.156047705308411 0.462447515724266 803 375 0.735895125279803 0.869123531847047 -PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I dysbiosisUC Yes 0.268003045041129 0.803683125968212 803 557 0.738888003503459 0.871678417871339 -COA_PWY_coenzyme_A_biosyn_I dysbiosisUC Yes -0.126489372038152 0.380530483449407 803 774 0.739690401529765 0.871678417871339 -PWY_621_sucrose_deg_III antibiotics Yes 0.105627377339508 0.318361543638464 803 741 0.740157115656402 0.871678417871339 -PWY_6121_5_aminoimidazole_rnt_biosyn_I dysbiosisnonIBD Yes 0.0611095891445962 0.185041265395744 803 799 0.741316731911619 0.872219686460696 -ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn dysbiosisnonIBD Yes 0.131379118968286 0.402854533463103 803 732 0.744444494382837 0.874402497798093 -FASYN_ELONG_PWY_fatty_acid_elongation__saturated diagnosis CD 0.417130322241406 1.27972430346895 803 532 0.744575481672373 0.874402497798093 -PWY4FS_7_phosphatidylglycerol_biosyn_I antibiotics Yes -0.159052162115578 0.491307497885968 803 604 0.746243809687764 0.874712875701744 -PWY4FS_8_phosphatidylglycerol_biosyn_II antibiotics Yes -0.15905250557691 0.491307523679502 803 604 0.746243293486031 0.874712875701744 -PWY_7400_L_arginine_biosyn_IV dysbiosisUC Yes -0.190502989997436 0.590507249996034 803 495 0.747096363737628 0.874889162798012 -HISTSYN_PWY_L_histidine_biosyn dysbiosisnonIBD Yes 0.152502470832566 0.476062596993807 803 698 0.748810920887657 0.875481103704638 -PWY0_1261_anhydromuropeptides_recycling diagnosis UC 0.423335147827941 1.32246733747156 803 273 0.749007107984867 0.875481103704638 -TRNA_CHARGING_PWY_tRNA_charging dysbiosisUC Yes -0.169228383582916 0.53275072664467 803 703 0.750851206395417 0.875878219441815 -PWY_7664_oleate_biosyn_IV diagnosis UC 0.409971702754576 1.29147339604599 803 531 0.751018506111841 0.875878219441815 -PWY0_1298_SP_of_pyrimidine_dns_deg dysbiosisUC Yes -0.211690395945891 0.668091087110369 803 455 0.75145571154358 0.875878219441815 -PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I dysbiosisnonIBD Yes -0.123543266304255 0.391054742327341 803 762 0.752160377502352 0.875880215297131 -HISDEG_PWY_L_histidine_deg_I dysbiosisCD Yes 0.21596730015537 0.68636880551295 803 582 0.753131770167206 0.876192516926553 -THRESYN_PWY_SP_of_L_threonine_biosyn dysbiosisUC Yes 0.0496704781269736 0.159008411651277 803 796 0.754852838792413 0.877375594342674 -PWY_3001_SP_of_L_isoleucine_biosyn_I diagnosis UC -0.123521375404074 0.397434508239167 803 782 0.756052930644416 0.877951492621568 -GLYCOLYSIS_glycolysis_I dysbiosisCD Yes -0.0520435336278372 0.1685979907287 803 791 0.757659182860031 0.878797773476621 -PWY0_1298_SP_of_pyrimidine_dns_deg dysbiosisnonIBD Yes 0.230136797523898 0.750699637114009 803 455 0.759277084462742 0.878797773476621 -PWY4FS_7_phosphatidylglycerol_biosyn_I dysbiosisnonIBD Yes -0.261403014797179 0.853895801223957 803 604 0.759602890878267 0.878797773476621 -PWY4FS_8_phosphatidylglycerol_biosyn_II dysbiosisnonIBD Yes -0.261403090691778 0.853895822642403 803 604 0.759602829082331 0.878797773476621 -BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn dysbiosisnonIBD Yes 0.112896465621535 0.375157870729839 803 773 0.763561941177644 0.880841753379917 -COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn dysbiosisUC Yes -0.0838936938290197 0.280210309961886 803 773 0.764732441798211 0.880841753379917 -PWY0_1296_purine_rns_deg dysbiosisCD Yes -0.0680553364987946 0.227377462941983 803 793 0.76480086195893 0.880841753379917 -PWY_5667_CDP_diacylglycerol_biosyn_I dysbiosisnonIBD Yes 0.044463898384773 0.148617766591676 803 801 0.764894375406821 0.880841753379917 -PWY0_1319_CDP_diacylglycerol_biosyn_II dysbiosisnonIBD Yes 0.0444621589488194 0.148618427281774 803 801 0.764904315535369 0.880841753379917 -PWY_5347_SP_of_L_methionine_biosyn diagnosis UC 0.356718924461374 1.2344424417713 803 373 0.772695174570634 0.888991862894746 -P105_PWY_TCA_cyc_IV antibiotics Yes -0.196893610492506 0.689073573220542 803 101 0.775301342518199 0.891167410311509 -GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg dysbiosisnonIBD Yes 0.2655476465265 0.935687274950436 803 300 0.776701863014292 0.89195439752609 -GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg antibiotics Yes 0.185626091844859 0.664197597089908 803 300 0.780016572024399 0.894936140646778 -MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn antibiotics Yes -0.130071058981006 0.483364344055773 803 375 0.78794176269503 0.901334191972009 -PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn diagnosis UC 0.251383350951145 0.932983806307204 803 604 0.787676195231889 0.901334191972009 -PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage diagnosis CD 0.197157515344014 0.73070647134782 803 754 0.787385904438386 0.901334191972009 -PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I diagnosis CD 0.205165492111917 0.764441315117026 803 765 0.788486572431372 0.901334191972009 -PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I age age -0.169264240812037 0.635010681833417 803 764 0.789896313780902 0.901419385411585 -PWY_3001_SP_of_L_isoleucine_biosyn_I dysbiosisCD Yes -0.0435260364050435 0.163959512723841 803 782 0.790731451247883 0.901419385411585 -PWY0_1298_SP_of_pyrimidine_dns_deg age age 0.255232102115433 0.959818829444496 803 455 0.790390026309314 0.901419385411585 -THRESYN_PWY_SP_of_L_threonine_biosyn dysbiosisnonIBD Yes 0.0461873596837441 0.175306969090521 803 796 0.792273701902337 0.902351949333009 -PWY_5030_L_histidine_deg_III diagnosis UC 0.337116334185386 1.28680054347796 803 542 0.793423260331164 0.902835965637105 -PWY_5103_L_isoleucine_biosyn_III dysbiosisnonIBD Yes 0.0986015289698954 0.37782448672827 803 778 0.794195431686576 0.902890061935651 -PWY_5690_TCA_cyc_II age age 0.277071771096113 1.07935667667695 803 363 0.797495709792947 0.905815546401105 -PWY_6353_purine_nt_deg_II diagnosis CD -0.323834678506285 1.27652058197829 803 432 0.799820573851985 0.907628811493236 -PWY_6700_queuosine_biosyn dysbiosisCD Yes -0.0595800127789427 0.23693581036459 803 780 0.801536084767376 0.907998981949413 -NONOXIPENT_PWY_pentose_phosphate_pwy dysbiosisUC Yes -0.0470643101259846 0.189680700603608 803 800 0.804115510234667 0.907998981949413 -P42_PWY_incomplete_reductive_TCA_cyc antibiotics Yes -0.0956143245121574 0.385064021356544 803 636 0.803974842934957 0.907998981949413 -PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I dysbiosisUC Yes -0.177495855948427 0.716782279963875 803 561 0.804500153745569 0.907998981949413 -PWY_6608_guanosine_nt_deg_III diagnosis UC 0.261717187517545 1.05700382569064 803 686 0.804519162176687 0.907998981949413 -PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn age age -0.202220095067756 0.816545811113082 803 469 0.804481157695523 0.907998981949413 -PWY_7242_D_fructuronate_deg dysbiosisCD Yes 0.0601520472742256 0.246813565466379 803 773 0.80752743995656 0.909898266819492 -PWY0_862_dodec_5_enoate_biosyn dysbiosisnonIBD Yes -0.197839526133001 0.812311204209021 803 546 0.807662506502695 0.909898266819492 -PWY_6703_preQ0_biosyn dysbiosisnonIBD Yes -0.103711807172342 0.430507568901722 803 771 0.809702650562521 0.911372631075791 -PWY_7456_mannan_deg diagnosis CD -0.370171614073062 1.55853982517557 803 210 0.812371581110832 0.9135514350759 -PWY_7199_pyrimidine_dns_salvage dysbiosisCD Yes 0.10530772168622 0.447316475451094 803 694 0.813954854021111 0.914506535717136 -PWY_6737_starch_deg_V antibiotics Yes -0.0408945501319276 0.176702139439964 803 800 0.817050630614332 0.916580906965318 -GLUCONEO_PWY_gluconeogenesis_I age age -0.368500142979767 1.59393068169962 803 457 0.817272381732318 0.916580906965318 -PYRIDNUCSYN_PWY_NAD_biosyn_I dysbiosisUC Yes 0.11174466801043 0.492622184135872 803 707 0.820621478534829 0.918767305417459 -SALVADEHYPOX_PWY_adenosine_nt_deg_II diagnosis CD 0.273855800156179 1.21113681157468 803 638 0.821182991104624 0.918767305417459 -PWY_6121_5_aminoimidazole_rnt_biosyn_I diagnosis CD 0.067838026110616 0.300446692941377 803 799 0.821434011424598 0.918767305417459 -ARO_PWY_chorismate_biosyn_I dysbiosisCD Yes -0.0500611262577478 0.22357696910993 803 775 0.822896496820575 0.918918111713627 -ILEUSYN_PWY_L_isoleucine_biosyn_I dysbiosisnonIBD Yes 0.0567967688822433 0.257521578088685 803 773 0.825509673283889 0.918918111713627 -PWY_5676_acetyl_CoA_fermentation_to_butanoate_II dysbiosisnonIBD Yes 0.230945131887436 1.04966788067506 803 459 0.825941110614405 0.918918111713627 -PWY_5989_stearate_biosyn_II diagnosis UC -0.277526905663685 1.26356832385296 803 575 0.826222384366417 0.918918111713627 -PWY0_1586_peptidoglycan_maturation dysbiosisnonIBD Yes 0.11467108571458 0.522470720025712 803 773 0.826345089864979 0.918918111713627 -PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III dysbiosisCD Yes -0.106966982434597 0.488010596691033 803 512 0.826571483763256 0.918918111713627 -PWY_6282_palmitoleate_biosyn_I diagnosis UC 0.284176302097339 1.30168025080474 803 531 0.827259318907059 0.918918111713627 -PWY_5971_palmitate_biosyn_II dysbiosisnonIBD Yes -0.181769157115772 0.833549045691114 803 143 0.827468797225272 0.918918111713627 -HISTSYN_PWY_L_histidine_biosyn dysbiosisUC Yes 0.091635730534338 0.436702858836862 803 698 0.833860780736067 0.922489700611257 -PWY_7111_pyruvate_fermentation_to_isobutanol antibiotics Yes 0.022185106285898 0.10588414290676 803 801 0.834104863066822 0.922489700611257 -DAPLYSINESYN_PWY_L_lysine_biosyn_I dysbiosisnonIBD Yes 0.117438135407148 0.56252420021486 803 595 0.834693966922357 0.922489700611257 -PWY_5347_SP_of_L_methionine_biosyn dysbiosisnonIBD Yes -0.158229834315263 0.759849787238873 803 373 0.835108130330313 0.922489700611257 -PWY_6737_starch_deg_V diagnosis CD -0.103501281286962 0.499765432807871 803 800 0.835995666335224 0.922489700611257 -P108_PWY_pyruvate_fermentation_to_propanoate_I diagnosis UC -0.587340452408876 2.84717610234567 803 350 0.836669269820281 0.922489700611257 -PWY_6545_pyrimidine_dnt_de_novo_biosyn_III dysbiosisUC Yes 0.0966118985627268 0.469209259275673 803 651 0.836929766815623 0.922489700611257 -PWY_5100_pyruvate_fermentation_to_acetate__lactate_II dysbiosisnonIBD Yes -0.0885502709787349 0.432738666196658 803 778 0.83792608791288 0.922489700611257 -PWY_7111_pyruvate_fermentation_to_isobutanol diagnosis CD 0.0619978300538635 0.303365376733173 803 801 0.83812963691681 0.922489700611257 -PWY_6123_inosine_5_phosphate_biosyn_I diagnosis CD 0.0734731643485725 0.360940574434466 803 794 0.838759690741995 0.922489700611257 -PWY_7208_SP_of_pyrimidine_nucleobases_salvage dysbiosisnonIBD Yes -0.0534369606995824 0.265239083751079 803 794 0.84039520602271 0.922489700611257 -PWY_6700_queuosine_biosyn dysbiosisnonIBD Yes 0.0725655245812201 0.361354023875383 803 780 0.840904446033669 0.922489700611257 -SALVADEHYPOX_PWY_adenosine_nt_deg_II dysbiosisnonIBD Yes -0.148332661692499 0.738835430988002 803 638 0.840944458114592 0.922489700611257 -COA_PWY_coenzyme_A_biosyn_I diagnosis CD -0.138675511226495 0.694110185224053 803 774 0.841707035393912 0.922489700611257 -PWY_6737_starch_deg_V dysbiosisCD Yes 0.0424936175633652 0.212806108165065 803 800 0.841790360830658 0.922489700611257 -PWYG_321_mycolate_biosyn dysbiosisnonIBD Yes 0.167735146967089 0.857985408466496 803 484 0.845071754975502 0.925271886379152 -GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff diagnosis CD -0.255267392740448 1.33281824077031 803 412 0.848177568770045 0.92627063598986 -PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg age age -0.122347047837042 0.639521392087413 803 757 0.84834130668595 0.92627063598986 -PWY_5177_glutaryl_CoA_deg diagnosis UC -0.158628710380949 0.834754953938385 803 753 0.849344647732232 0.92627063598986 -PWY_5177_glutaryl_CoA_deg dysbiosisUC Yes 0.0885627417906763 0.469283093366267 803 753 0.850371698610298 0.92627063598986 -PWY_7456_mannan_deg dysbiosisnonIBD Yes 0.125454843120781 0.664358224936159 803 210 0.850309313957307 0.92627063598986 -GLYOXYLATE_BYPASS_glyoxylate_cyc dysbiosisUC Yes 0.227231394782882 1.206772526039 803 255 0.850747509230956 0.92627063598986 -PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I diagnosis CD -0.260149593841918 1.38614995307807 803 557 0.851187703217006 0.92627063598986 -P42_PWY_incomplete_reductive_TCA_cyc dysbiosisCD Yes 0.0840338664362764 0.451316042401583 803 636 0.852348068912442 0.926723991156111 -PWY_7663_gondoate_biosyn dysbiosisnonIBD Yes -0.0537172737902702 0.291150908980207 803 792 0.853677916859087 0.927360666439776 -PWY0_1296_purine_rns_deg dysbiosisnonIBD Yes 0.0625072462667913 0.344135753104926 803 793 0.855924439988012 0.928991160474794 -METSYN_PWY_L_homoserine__L_methionine_biosyn diagnosis UC 0.22494315817607 1.26302081987782 803 375 0.858700460773475 0.930868089695393 -PWY_6317_galactose_deg_I dysbiosisnonIBD Yes 0.0749243062973063 0.422042002837425 803 765 0.859147915850483 0.930868089695393 -PWY_5676_acetyl_CoA_fermentation_to_butanoate_II dysbiosisUC Yes -0.164662134883282 0.941536336143942 803 459 0.861234496129845 0.932054349526218 -PWY_6936_seleno_amino_acid_biosyn age age -0.200271404240695 1.14947099864908 803 472 0.86173885285249 0.932054349526218 -PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III dysbiosisnonIBD Yes -0.124152143742055 0.725512561407791 803 512 0.86418044046955 0.933884500281925 -PWY_5973_cis_vaccenate_biosyn antibiotics Yes 0.028895304772786 0.171792649218507 803 787 0.866478315847045 0.935556309831385 -PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn dysbiosisnonIBD Yes -0.118247531993996 0.710556538166236 803 281 0.867885401954466 0.935948651431689 -PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I dysbiosisnonIBD Yes -0.0830216412694181 0.500894992235878 803 764 0.868407130367263 0.935948651431689 -ANAGLYCOLYSIS_PWY_glycolysis_III antibiotics Yes -0.0133590850747806 0.0810270331961438 803 801 0.869095176329426 0.935948651431689 -PWY_4041_beta_glutamyl_cyc diagnosis UC -0.25817162028226 1.6535815117512 803 247 0.876030913340216 0.942603210727037 -COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I dysbiosisUC Yes -0.0787351438771078 0.522700340603291 803 578 0.880312775487477 0.945806883940904 -PWY_2942_L_lysine_biosyn_III dysbiosisnonIBD Yes 0.0199969510902619 0.132993905795575 803 802 0.880526473010793 0.945806883940904 -PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II dysbiosisnonIBD Yes 0.0576734563154087 0.388458096407553 803 769 0.882018935366513 0.946593965087575 -PWY_1042_glycolysis_IV antibiotics Yes 0.0116944171955477 0.0794013056001752 803 803 0.882953943922789 0.946781939869015 -PWY_6608_guanosine_nt_deg_III dysbiosisnonIBD Yes -0.0924405874593764 0.643448750311384 803 686 0.885809715688456 0.949027434005001 -PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg antibiotics Yes 0.0403007674655291 0.288906690220914 803 757 0.88910230389338 0.950896367894712 -P42_PWY_incomplete_reductive_TCA_cyc dysbiosisnonIBD Yes -0.0899382153227724 0.646719345891856 803 636 0.88943918556675 0.950896367894712 -CITRULBIO_PWY_L_citrulline_biosyn antibiotics Yes 0.0517954397944503 0.375806660793246 803 688 0.890422449704325 0.950896367894712 -PWY_6121_5_aminoimidazole_rnt_biosyn_I antibiotics Yes -0.0147371955371993 0.1071099832981 803 799 0.890606790797054 0.950896367894712 -COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn dysbiosisCD Yes -0.0262218053641652 0.210268840261518 803 773 0.900794148982401 0.958780842785606 -TCA_TCA_cyc_I antibiotics Yes -0.0579989326577037 0.467364248046798 803 412 0.901280369636784 0.958780842785606 -PWY_2941_L_lysine_biosyn_II dysbiosisUC Yes -0.0759920894188074 0.614135201655025 803 454 0.901565670422057 0.958780842785606 -THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III dysbiosisUC Yes -0.0560355310499906 0.453741830774805 803 682 0.901751481883434 0.958780842785606 -ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn dysbiosisnonIBD Yes 0.0273035677780393 0.221285449350551 803 797 0.901838802363347 0.958780842785606 -PWY_5695_urate_biosyn_inosine_5_phosphate_deg dysbiosisCD Yes 0.0139788457376751 0.114877208206962 803 800 0.903185333013087 0.959393797897959 -PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn antibiotics Yes -0.048324961427428 0.421899359947766 803 281 0.908846410616321 0.964584861693301 -PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisCD Yes -0.0465438226969306 0.412298747305241 803 469 0.910153793995254 0.965150321121776 -PWY_5103_L_isoleucine_biosyn_III dysbiosisCD Yes -0.0282356598813225 0.252995704324355 803 778 0.911170203978702 0.965406525644101 -ANAEROFRUCAT_PWY_homolactic_fermentation dysbiosisUC Yes -0.0363899691135754 0.346078424943541 803 770 0.91628913869682 0.969564714463497 -PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage diagnosis UC -0.0751960609852279 0.718248294667162 803 754 0.916651070335473 0.969564714463497 -PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn dysbiosisUC Yes -0.0889591928653919 0.865607190257418 803 504 0.918177027858938 0.969795051094357 -PWY_6122_5_aminoimidazole_rnt_biosyn_II dysbiosisnonIBD Yes -0.0196503156912319 0.195662253257014 803 799 0.920033540519694 0.969795051094357 -PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn dysbiosisnonIBD Yes -0.0196503156912319 0.195662253257014 803 799 0.920033540519694 0.969795051094357 -PWY_5971_palmitate_biosyn_II dysbiosisUC Yes 0.0728613083149265 0.742424672949282 803 143 0.921861853791118 0.969795051094357 -PWY_4981_L_proline_biosyn_II diagnosis UC -0.119866556680548 1.23967077022853 803 678 0.923000507523741 0.969795051094357 -TCA_TCA_cyc_I dysbiosisnonIBD Yes -0.0740854795279648 0.757600185564247 803 412 0.922132797501894 0.969795051094357 -PWY_5676_acetyl_CoA_fermentation_to_butanoate_II antibiotics Yes -0.0520715847287085 0.539485891298495 803 459 0.92314293552131 0.969795051094357 -PWY_2941_L_lysine_biosyn_II diagnosis CD -0.100571419030936 1.05203284097962 803 454 0.923873776604335 0.969795051094357 -PWYG_321_mycolate_biosyn diagnosis UC 0.129542936546548 1.35405759250401 803 484 0.92381597186697 0.969795051094357 -PWY_6168_flavin_biosyn_III dysbiosisCD Yes 0.0210262201240808 0.223650084563226 803 760 0.925126635847414 0.969975761313961 -PWY_7242_D_fructuronate_deg dysbiosisnonIBD Yes -0.0337257070019986 0.368756076009817 803 773 0.927156314756178 0.969975761313961 -PWY_5913_TCA_cyc_VI age age 0.126547931395743 1.391198558715 803 146 0.927575522217394 0.969975761313961 -PWY_6527_stachyose_deg antibiotics Yes 0.0228121251527716 0.256495129890488 803 766 0.929158202137398 0.969975761313961 -PWY0_1297_SP_of_purine_dns_deg diagnosis CD -0.100832188804933 1.13300515503176 803 610 0.929112686436587 0.969975761313961 -PWY_7199_pyrimidine_dns_salvage antibiotics Yes -0.0342698005317897 0.388305330695138 803 694 0.92970091185894 0.969975761313961 -THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III diagnosis UC 0.0728839364636277 0.830942782982634 803 682 0.930131876269445 0.969975761313961 -PWY_4984_urea_cyc dysbiosisCD Yes 0.0385780788664417 0.440715310875567 803 665 0.930273703667884 0.969975761313961 -GLUCONEO_PWY_gluconeogenesis_I dysbiosisCD Yes 0.0657078498296809 0.77214888409468 803 457 0.932221732702764 0.971106644618044 -P108_PWY_pyruvate_fermentation_to_propanoate_I antibiotics Yes -0.0433707626934002 0.514922349515534 803 350 0.932917057470143 0.971106644618044 -MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn diagnosis UC 0.107224087625103 1.31874264816315 803 375 0.935222185332207 0.972693524978239 -UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I dysbiosisUC Yes -0.051109687020578 0.642023495327236 803 503 0.936575280590462 0.972752017705149 -GALACTUROCAT_PWY_D_galacturonate_deg_I dysbiosisnonIBD Yes 0.0308794563869534 0.39093102042902 803 776 0.937064823461543 0.972752017705149 -PWY_6385_peptidoglycan_biosyn_III dysbiosisCD Yes -0.00802234038908031 0.102968231740987 803 797 0.937922526805794 0.972752017705149 -PWY_5989_stearate_biosyn_II dysbiosisnonIBD Yes -0.0603830435344772 0.790541505518898 803 575 0.939138755449113 0.972752017705149 -BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn diagnosis UC 0.0463644514745955 0.608032767520577 803 773 0.939240687330655 0.972752017705149 -PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn dysbiosisnonIBD Yes 0.0274051750754147 0.363726594392682 803 761 0.939962623849919 0.972752017705149 -PWY_5030_L_histidine_deg_III dysbiosisnonIBD Yes -0.0539881102213815 0.72664454126363 803 542 0.940797255404288 0.972807784426343 -ANAEROFRUCAT_PWY_homolactic_fermentation dysbiosisnonIBD Yes 0.0271297002305995 0.381503624967731 803 770 0.943329712669079 0.974617597003045 -CALVIN_PWY_Calvin_Benson_Bassham_cyc dysbiosisnonIBD Yes -0.0133025367876289 0.198095170017496 803 797 0.946480802943573 0.976922903050227 -PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II antibiotics Yes -0.00492090595456757 0.0741797392182566 803 798 0.947129106649016 0.976922903050227 -PWY_6969_TCA_cyc_V dysbiosisUC Yes 0.0454512536966596 0.69779040377758 803 403 0.948088032679776 0.977103133762614 -PWY_7234_inosine_5_phosphate_biosyn_III dysbiosisUC Yes -0.0336584248692976 0.540726399461216 803 690 0.950385760530305 0.978441280256683 -PWY_7184_pyrimidine_dnt_de_novo_biosyn_I dysbiosisCD Yes 0.017303399804992 0.282294818399502 803 747 0.951142437301528 0.978441280256683 -GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff dysbiosisnonIBD Yes -0.0493550644200705 0.815198291359547 803 412 0.951742240506501 0.978441280256683 -PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn dysbiosisnonIBD Yes 0.0300221545726827 0.570910948438535 803 604 0.958077556158097 0.98414232067023 -ARGSYNBSUB_PWY_L_arginine_biosyn_II dysbiosisUC Yes 0.0457121089902166 0.927760983818756 803 428 0.960718679454996 0.985230843292942 -PWY_5104_L_isoleucine_biosyn_IV dysbiosisnonIBD Yes 0.0494040857909967 1.00031136015113 803 475 0.960625081474071 0.985230843292942 -GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff dysbiosisCD Yes 0.0262124697223964 0.550214090396143 803 412 0.962018152223514 0.985687538806161 -PWY_6608_guanosine_nt_deg_III diagnosis CD 0.0478450063123303 1.05658847599722 803 686 0.963895887556101 0.985687538806161 -HISTSYN_PWY_L_histidine_biosyn dysbiosisCD Yes 0.0135922847711068 0.31630741597706 803 698 0.965737026482241 0.985687538806161 -P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate antibiotics Yes -0.0240538647239848 0.573359473286855 803 283 0.966550112395356 0.985687538806161 -HISDEG_PWY_L_histidine_deg_I dysbiosisnonIBD Yes 0.0415925508420151 0.996250186918543 803 582 0.966712150998193 0.985687538806161 -PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I antibiotics Yes 0.0200983100396889 0.491502438929902 803 557 0.967394869592443 0.985687538806161 -PWY_6122_5_aminoimidazole_rnt_biosyn_II antibiotics Yes 0.00453347038158871 0.113378050072796 803 799 0.968116795675862 0.985687538806161 -PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn antibiotics Yes 0.00453347038158871 0.113378050072796 803 799 0.968116795675862 0.985687538806161 -PWY_6703_preQ0_biosyn antibiotics Yes -0.00983419995339298 0.247239878250504 803 771 0.968283745986149 0.985687538806161 -PWY_5686_UMP_biosyn dysbiosisnonIBD Yes 0.00507251037577262 0.134610871035147 803 802 0.969951974799872 0.986579722939298 -DAPLYSINESYN_PWY_L_lysine_biosyn_I diagnosis CD 0.0320312898600805 0.917751470826065 803 595 0.972168780086395 0.987333852023253 -PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II dysbiosisnonIBD Yes 0.00635812800895734 0.182892662270201 803 794 0.972278199384054 0.987333852023253 -P441_PWY_SP_of_N_acetylneuraminate_deg dysbiosisUC Yes 0.026120504500991 0.804928402529169 803 433 0.974122563199118 0.988401232692265 -COA_PWY_1_coenzyme_A_biosyn_II dysbiosisUC Yes -0.00443676111558989 0.144086347495514 803 800 0.975444400777788 0.988937122350792 -PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II dysbiosisCD Yes -0.00762181040173672 0.257133436417523 803 769 0.976361933415713 0.989021099428811 -PWY_7187_pyrimidine_dnt_de_novo_biosyn_II dysbiosisUC Yes 0.0155677748115582 0.542483348642372 803 647 0.977114745904387 0.989021099428811 -PWY_5188_tetrapyrrole_biosyn_I diagnosis CD 0.0161561973304931 0.898160398629294 803 731 0.985653784615171 0.99627938123841 -P441_PWY_SP_of_N_acetylneuraminate_deg dysbiosisnonIBD Yes 0.0154789154034146 0.874589918630729 803 433 0.985884813055345 0.99627938123841 -ARO_PWY_chorismate_biosyn_I dysbiosisUC Yes -0.00423178103218442 0.297912175250598 803 775 0.988670881667083 0.996365687682218 -PWY_5103_L_isoleucine_biosyn_III diagnosis UC 0.00842088859155836 0.612735586484234 803 778 0.989039075680625 0.996365687682218 -P105_PWY_TCA_cyc_IV age age 0.0130975321654818 0.963904254482852 803 101 0.989168824769586 0.996365687682218 -PWY_7221_guanosine_rnt_de_novo_biosyn age age 0.00207316831914338 0.152577328628849 803 802 0.989163046092105 0.996365687682218 -PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg dysbiosisnonIBD Yes 0.00598816494841404 0.509153068414361 803 757 0.990619825485728 0.996870878908397 -PWY_6527_stachyose_deg dysbiosisnonIBD Yes 0.00461718143263824 0.447211410165269 803 766 0.991765591825146 0.996870878908397 -PWY0_1298_SP_of_pyrimidine_dns_deg antibiotics Yes 0.00431919130686092 0.434429717255316 803 455 0.992070537597442 0.996870878908397 -PWY_841_SP_of_purine_nt_de_novo_biosyn_I diagnosis CD 0.0102593924254689 1.15522935549674 803 651 0.992916922254823 0.996917393335624 -PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II dysbiosisnonIBD Yes -0.000732674737016044 0.129338200048041 803 798 0.9954818787352 0.998173374424882 -PWY_7196_SP_of_pyrimidine_rns_salvage dysbiosisCD Yes 0.00266131653109145 0.501793662220062 803 411 0.995770067744886 0.998173374424882 -PWY_5103_L_isoleucine_biosyn_III dysbiosisUC Yes -0.00136375755753005 0.340058718438611 803 778 0.996801413177416 0.998403987796672 -PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I antibiotics Yes 0.00112223287501605 0.44144301941905 803 561 0.99797240890865 0.998470162329998 -PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I dysbiosisnonIBD Yes 0.00020911863361454 0.109024265206503 803 799 0.998470162329998 0.998470162329998 +NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I dysbiosisCD Yes -0.618633313279904 0.0924319217817194 803 799 4.57663979099407e-11 5.70249317957861e-08 +PWY0_1261_anhydromuropeptides_recycling dysbiosisCD Yes 2.96249879369237 0.471855942629623 803 273 6.8599471822699e-10 4.27374709455415e-07 +PWY_5173_SP_of_acetyl_CoA_biosyn dysbiosisCD Yes 2.94208859054454 0.480266927945764 803 335 2.02929351664638e-09 8.42833240580463e-07 +PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn dysbiosisCD Yes -1.1470771577878 0.194875749038429 803 761 6.92706938086865e-09 2.15778211214058e-06 +PWY_7208_SP_of_pyrimidine_nucleobases_salvage dysbiosisCD Yes -0.822329491615039 0.145579340919081 803 794 2.49226234696658e-08 6.21071776864072e-06 +PWY_5097_L_lysine_biosyn_VI dysbiosisCD Yes -0.439251369576312 0.080948197644148 803 802 8.56790491098012e-08 1.7792682531802e-05 +ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn dysbiosisCD Yes 0.64130934427015 0.124271967866938 803 797 3.31993481305146e-07 5.9094839672316e-05 +PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I dysbiosisCD Yes -0.817284584546322 0.162578410138359 803 783 6.87257633307663e-07 0.000107040376387669 +UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I dysbiosisCD Yes 1.76264917945981 0.366609958119706 803 503 2.03910197340086e-06 0.000282302339873052 +PWY_5723_Rubisco_shunt dysbiosisCD Yes 2.41652915791416 0.542113958383048 803 212 1.12598100325778e-05 0.00140297233005919 +PWYG_321_mycolate_biosyn dysbiosisCD Yes -2.13446387947385 0.488709827480479 803 484 1.52720989928251e-05 0.00172991230409637 +GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg dysbiosisCD Yes 2.16700389549834 0.499847930829683 803 300 1.81801024440753e-05 0.00188770063710982 +PWY_5083_NAD_NADH_phosphorylation__dephosphorylation dysbiosisCD Yes 1.96850253625639 0.457763684079564 803 431 2.03368666625553e-05 0.00194921045088799 +FUCCAT_PWY_fucose_deg dysbiosisCD Yes 2.10484912666633 0.503707644195467 803 268 3.47541901155345e-05 0.00309312292028257 +PWY0_1298_SP_of_pyrimidine_dns_deg dysbiosisCD Yes 1.63963992674933 0.408009987284711 803 455 6.69756521434233e-05 0.00556344417138036 +PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II dysbiosisCD Yes -0.286895010072458 0.0741949316042205 803 798 0.00012097600780991 0.00942100660819674 +CITRULBIO_PWY_L_citrulline_biosyn dysbiosisCD Yes -1.443146698241 0.379536791072413 803 688 0.000157151459049691 0.011518277527995 +PWY_7456_mannan_deg dysbiosisUC Yes 2.2945779392424 0.607182533870461 803 210 0.000175600521071577 0.0121554582919547 +PWY_5686_UMP_biosyn dysbiosisCD Yes -0.290623736376054 0.0776565557664913 803 802 0.000197561911040696 0.0129559021661425 +PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I age age -0.535992327359665 0.138821714950822 803 557 0.000214757065684506 0.0130080685528097 +PWY_5484_glycolysis_II dysbiosisUC Yes -0.792099678122814 0.213291248235628 803 791 0.000219237110440613 0.0130080685528097 +PWY_4041_beta_glutamyl_cyc dysbiosisCD Yes 2.00199208424061 0.539069441732202 803 247 0.000238901979685604 0.013530539394921 +PWY_7197_pyrimidine_dnt_phosphorylation dysbiosisCD Yes -0.942711709954558 0.25761491339299 803 751 0.000275589359856416 0.0149297540165693 +PWY_7221_guanosine_rnt_de_novo_biosyn antibiotics Yes 0.234847899249754 0.0653759723735983 803 802 0.000348879672058809 0.0181126696410532 +PWY_6609_adenine__adenosine_salvage_III dysbiosisCD Yes -0.504989595255633 0.143289851300085 803 792 0.000463653330920992 0.0231084820131022 +PWY66_409_SP_of_purine_nt_salvage dysbiosisCD Yes 1.24431301989943 0.355727482979021 803 290 0.000508576718694727 0.0236799336010274 +PWY_621_sucrose_deg_III dysbiosisCD Yes -1.06273392924442 0.304176170228449 803 741 0.000513128577229326 0.0236799336010274 +VALSYN_PWY_L_valine_biosyn dysbiosisUC Yes 0.545762265356123 0.160524185932954 803 802 0.00070950913871425 0.0312265203685879 +X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn dysbiosisCD Yes -0.597692711349317 0.176976685545883 803 779 0.000776903797292316 0.0312265203685879 +FASYN_ELONG_PWY_fatty_acid_elongation__saturated age age -0.558052848474461 0.160360213636686 803 532 0.000774905278396707 0.0312265203685879 +TCA_TCA_cyc_I dysbiosisCD Yes 1.26856596249795 0.37470513520993 803 412 0.000773718903672318 0.0312265203685879 +P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate dysbiosisCD Yes 1.73387526324221 0.515878036656341 803 283 0.000830753929478712 0.0323474811290774 +PWY_7664_oleate_biosyn_IV age age -0.563448388427534 0.164461727011425 803 531 0.000921670014420038 0.0348000253929505 +PWY_6270_isoprene_biosyn_I dysbiosisCD Yes 1.33226079885382 0.40555992622629 803 219 0.00108243664687847 0.0386167812256071 +PWY_6282_palmitoleate_biosyn_I age age -0.558469124979553 0.165450375323472 803 531 0.00108474104566312 0.0386167812256071 +PWY_7111_pyruvate_fermentation_to_isobutanol dysbiosisUC Yes 0.512528705095113 0.156845257116594 803 801 0.00113314267784267 0.0392193271275546 +GLYCOLYSIS_glycolysis_I dysbiosisUC Yes -0.691763452770188 0.212553893016718 803 791 0.00118593811220563 0.0399372672380599 +PWY66_400_glycolysis_VI dysbiosisCD Yes -0.446091676058877 0.137743676255786 803 789 0.00128760105275506 0.0422197608350738 +PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine dysbiosisCD Yes 1.12656624773753 0.352354738894867 803 597 0.00147796405880232 0.045230209391779 +GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisCD Yes 1.13569269806603 0.356004363778927 803 706 0.00150594654379153 0.045230209391779 +PWY_6700_queuosine_biosyn diagnosis UC 0.696936803662394 0.214956076299978 803 780 0.00160317757450049 0.045230209391779 +PWY_6897_thiamin_salvage_II dysbiosisCD Yes 1.06527375058191 0.335795364969092 803 589 0.00159563539296119 0.045230209391779 +PWY_4984_urea_cyc dysbiosisUC Yes -1.79683774077562 0.568243937070938 803 665 0.00163351478541738 0.045230209391779 +PWY_7560_methylerythritol_phosphate_pwy_II dysbiosisCD Yes 1.3163941368664 0.415797110052004 803 226 0.00162755959366917 0.045230209391779 +PWY0_862_dodec_5_enoate_biosyn age age -0.526457320871371 0.162097257084328 803 546 0.00162706584207162 0.045230209391779 +RIBOSYN2_PWY_flavin_biosyn_I dysbiosisCD Yes 1.23404231759102 0.393541190009151 803 478 0.00180165000171554 0.0482419683372991 +PWY_6901_SP_of_glucose__xylose_deg diagnosis UC -1.16659244842496 0.363753637210181 803 436 0.00183497224375232 0.0482419683372991 +PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage dysbiosisUC Yes -1.24803654414667 0.399613795218526 803 754 0.00185843858763271 0.0482419683372991 +PWY_6151_S_adenosyl_L_methionine_cyc_I age age -0.202713904738836 0.0635664845667934 803 791 0.00193221269505651 0.0490815704600589 +PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn dysbiosisCD Yes 0.997977311365132 0.321390409529009 803 604 0.00199106168029858 0.0490815704600589 +ANAGLYCOLYSIS_PWY_glycolysis_III dysbiosisCD Yes -0.24208299820517 0.0780186791715543 803 801 0.00200895673632665 0.0490815704600589 +PYRIDNUCSYN_PWY_NAD_biosyn_I dysbiosisCD Yes -0.9287510817242 0.300813020394954 803 707 0.00211247850024277 0.0506182348327402 +PWY_5690_TCA_cyc_II diagnosis UC -1.33632761398017 0.425565750329088 803 363 0.00219444765578908 0.0515902222474188 +PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisCD Yes -0.634846939391826 0.20675514787451 803 742 0.00225730537506186 0.0520852314319829 +PWY_2942_L_lysine_biosyn_III dysbiosisCD Yes -0.221053593129319 0.0743552011668912 803 802 0.0030601884547503 0.0693271784476159 +PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I dysbiosisUC Yes 0.759965352103471 0.257891261069081 803 783 0.00330814571295482 0.0736062421132447 +CITRULBIO_PWY_L_citrulline_biosyn dysbiosisUC Yes -1.6541219120814 0.56593390090318 803 688 0.00357826514530312 0.0782196205446963 +PWY_7199_pyrimidine_dns_salvage diagnosis UC -1.23586415204619 0.41599506926134 803 694 0.00367858796367093 0.0790262172885169 +PWY_1042_glycolysis_IV dysbiosisCD Yes -0.236895460432705 0.0821076927389324 803 803 0.00403683091211355 0.0852523951948048 +PWY_5690_TCA_cyc_II diagnosis CD -1.14831016033153 0.393054803391649 803 363 0.00420249951974296 0.0858412196983562 +PWY_5690_TCA_cyc_II dysbiosisCD Yes 1.26338136558261 0.439173202621499 803 363 0.00419041816821215 0.0858412196983562 +PYRIDNUCSYN_PWY_NAD_biosyn_I diagnosis UC -0.976396039843521 0.334014919042906 803 707 0.00435994928725515 0.087620916321289 +PWY_5695_urate_biosyn_inosine_5_phosphate_deg dysbiosisUC Yes -0.420305583437807 0.147629549462274 803 800 0.00453310385983108 0.0896547207833258 +PWY_7219_adenosine_rnt_de_novo_biosyn antibiotics Yes 0.172348923778522 0.0610005693523868 803 803 0.00484677803818674 0.0943607099309481 +PWY_5083_NAD_NADH_phosphorylation__dephosphorylation age age -0.499122848069624 0.17325064658291 803 431 0.00512994054185098 0.0983370140791742 +PWY_5030_L_histidine_deg_III age age 0.669768233550353 0.234451288671946 803 542 0.00528153624565419 0.0994128624150221 +PWY_7221_guanosine_rnt_de_novo_biosyn dysbiosisUC Yes 0.296205466033337 0.106059785568759 803 802 0.00536278912019371 0.0994128624150221 +PWY_5030_L_histidine_deg_III antibiotics Yes -1.1378099419977 0.407939276410625 803 542 0.00542542106277809 0.0994128624150221 +PWYG_321_mycolate_biosyn dysbiosisUC Yes -2.06370193958469 0.742027141373566 803 484 0.00556752612776979 0.100538225437698 +PWY_6608_guanosine_nt_deg_III dysbiosisCD Yes -0.9500595195963 0.342183308463509 803 686 0.00569951193317593 0.101451312410532 +PWY_5676_acetyl_CoA_fermentation_to_butanoate_II dysbiosisCD Yes -1.53795805104683 0.556983075326516 803 459 0.00593878661529487 0.10422152285433 +PWY0_1296_purine_rns_deg age age -0.193563750776857 0.0691608666572281 803 793 0.00622609544541396 0.107746040624803 +PWY4FS_7_phosphatidylglycerol_biosyn_I age age -0.378406559573777 0.137837610777862 803 604 0.00727054230012572 0.119674583304877 +PWY4FS_8_phosphatidylglycerol_biosyn_II age age -0.378406903065047 0.137837660954131 803 604 0.00727051163546652 0.119674583304877 +GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg antibiotics Yes -0.6298522987308 0.234257658887376 803 755 0.00733986227256078 0.119674583304877 +PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn dysbiosisCD Yes -1.33137496372798 0.494835897030698 803 504 0.00734774069396818 0.119674583304877 +PWY_7199_pyrimidine_dns_salvage dysbiosisUC Yes -1.58461769894282 0.590008867188131 803 694 0.00739562031659351 0.119674583304877 +PWY_5973_cis_vaccenate_biosyn dysbiosisnonIBD Yes 0.734138465085068 0.277280020301585 803 787 0.00827348197417705 0.12921524057127 +THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III dysbiosisCD Yes 0.754318786221792 0.284465658290248 803 682 0.0082436805991518 0.12921524057127 +PWY0_1261_anhydromuropeptides_recycling dysbiosisnonIBD Yes 2.09814252862597 0.792255588571547 803 273 0.00831227953224553 0.12921524057127 +PWY_5971_palmitate_biosyn_II age age -0.383678181929206 0.141550997120608 803 143 0.0084000276775866 0.12921524057127 +PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I diagnosis UC 0.428338656454306 0.159968996890715 803 792 0.00874074619851681 0.132816704431121 +PWY_6163_chorismate_biosyn_from_3_dehydroquinate dysbiosisCD Yes -0.490331694516463 0.188696017874289 803 787 0.00957676903168428 0.143766918234682 +PANTO_PWY_phosphopantothenate_biosyn_I dysbiosisCD Yes -0.292847321608844 0.113857832466468 803 798 0.0103177493306308 0.153046615071024 +PWY_5690_TCA_cyc_II antibiotics Yes -1.12208062708696 0.437237294255074 803 363 0.0104872613045972 0.153730912770919 +GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisnonIBD Yes 1.5179964283044 0.592931307732504 803 706 0.0106785076434965 0.15471419213717 +COA_PWY_1_coenzyme_A_biosyn_II dysbiosisCD Yes -0.233170588772712 0.091623382614227 803 800 0.0111612451381914 0.157378436002368 +COA_PWY_coenzyme_A_biosyn_I diagnosis UC 0.646197966203477 0.249562397355943 803 774 0.0111643136936702 0.157378436002368 +PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I dysbiosisCD Yes -0.157330733238568 0.0618864576804341 803 799 0.011241316857312 0.157378436002368 +P105_PWY_TCA_cyc_IV diagnosis UC -1.44577315564917 0.560161920928689 803 101 0.0115233549287241 0.157781321331761 +PWYG_321_mycolate_biosyn age age -0.422409603544552 0.16372454925245 803 484 0.0115224152334863 0.157781321331761 +PWY_4984_urea_cyc dysbiosisCD Yes -0.968846384633195 0.38602606767937 803 665 0.0123165946551287 0.165179780079184 +PWY_7237_myo__chiro__scillo_inositol_deg dysbiosisCD Yes 1.24761961443681 0.496570773418466 803 441 0.0123288278871301 0.165179780079184 +PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I diagnosis UC -0.607612849125228 0.239459336817358 803 764 0.012604329441017 0.167074409399013 +PWY_6901_SP_of_glucose__xylose_deg diagnosis CD -0.84052191004695 0.335470159271474 803 436 0.0138423909924132 0.181553886068914 +PWY_7219_adenosine_rnt_de_novo_biosyn dysbiosisUC Yes 0.243862775740808 0.0996183085787118 803 803 0.0145977270972915 0.189466332950263 +PWY_5100_pyruvate_fermentation_to_acetate__lactate_II diagnosis CD 0.477304065107603 0.192807701246637 803 778 0.0150099861370422 0.192390340310128 +PWY_7199_pyrimidine_dns_salvage diagnosis CD -0.950684863496419 0.385336377337959 803 694 0.0151318245187741 0.192390340310128 +FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation age age -0.574510717329775 0.178679134332171 803 539 0.0153486152425512 0.193175500931503 +RIBOSYN2_PWY_flavin_biosyn_I diagnosis CD -1.00820570940542 0.410741491886951 803 478 0.0158719759498275 0.197764820334851 +PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I dysbiosisCD Yes 1.0409163590731 0.430789374055662 803 557 0.0160703097192685 0.198253523863451 +OANTIGEN_PWY_O_antigen_building_blocks_biosyn dysbiosisCD Yes 0.807347119497748 0.335973887803261 803 445 0.0166034832834305 0.201538217457481 +PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn diagnosis UC -1.27196952378674 0.522122040884236 803 504 0.0166600613147035 0.201538217457481 +GLUCONEO_PWY_gluconeogenesis_I diagnosis UC -2.04706270142405 0.844604302625734 803 457 0.0176548028326441 0.21151811855264 +PWY_5188_tetrapyrrole_biosyn_I dysbiosisCD Yes 0.743025838196263 0.313732912113337 803 731 0.0181508494937043 0.211939077873875 +PWY_6163_chorismate_biosyn_from_3_dehydroquinate diagnosis UC -0.526255995859031 0.219176996864048 803 787 0.0182027417981987 0.211939077873875 +PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn antibiotics Yes -0.443131740643846 0.187323411992618 803 761 0.0182597756534306 0.211939077873875 +PWY_7199_pyrimidine_dns_salvage dysbiosisnonIBD Yes -1.4499709029318 0.61392119403375 803 694 0.0184472854019822 0.211939077873875 +P105_PWY_TCA_cyc_IV diagnosis CD -1.22730544833912 0.512148876285502 803 101 0.0185404169247611 0.211939077873875 +PWY_6608_guanosine_nt_deg_III age age -0.454554518614291 0.187723286405032 803 686 0.0188083800516826 0.213047650403605 +PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I diagnosis UC -0.920044125219964 0.385872763866869 803 557 0.019018137819772 0.213482880391315 +PWY_5667_CDP_diacylglycerol_biosyn_I dysbiosisUC Yes -0.29835370583141 0.127495273356018 803 801 0.0195424558618911 0.215533337094297 +PWY0_1319_CDP_diacylglycerol_biosyn_II dysbiosisUC Yes -0.29834455205438 0.127495880207699 803 801 0.0195467633159354 0.215533337094297 +GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisUC Yes 1.34058344043664 0.576860920810617 803 706 0.0203915173347132 0.222875707009234 +TRNA_CHARGING_PWY_tRNA_charging dysbiosisCD Yes -0.770881051243798 0.333199575438021 803 703 0.0210163024192548 0.227507010642096 +PWY_5101_L_isoleucine_biosyn_II dysbiosisnonIBD Yes 1.41211152928141 0.611319589879527 803 574 0.0211804279570491 0.227507010642096 +PWY66_399_gluconeogenesis_III age age 0.413612641234371 0.177250759163526 803 670 0.0217577105918344 0.231710319636117 +P161_PWY_acetylene_deg dysbiosisCD Yes 0.908709966849317 0.397040986171315 803 537 0.0224551761878914 0.23445892946571 +PWY_3841_folate_transformations_II age age 0.137986840851213 0.0595675879634972 803 787 0.0224872238720809 0.23445892946571 +P42_PWY_incomplete_reductive_TCA_cyc dysbiosisUC Yes -1.26959036092065 0.557008145277737 803 636 0.0229295199344193 0.23445892946571 +PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn antibiotics Yes -0.706584381124543 0.310039483145919 803 469 0.0229566528048287 0.23445892946571 +PWY_7242_D_fructuronate_deg dysbiosisUC Yes 0.72540730623106 0.317985637087995 803 773 0.0228084538196858 0.23445892946571 +PWY_6353_purine_nt_deg_II dysbiosisnonIBD Yes -1.53413183614004 0.677607456879996 803 432 0.0239140278868041 0.240297409249661 +PWY66_400_glycolysis_VI dysbiosisUC Yes -0.529300554759636 0.233756229286142 803 789 0.0238446945705259 0.240297409249661 +DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II age age -0.263716556079211 0.115900449636304 803 614 0.0252435659478072 0.251627865367742 +PWY_6901_SP_of_glucose__xylose_deg dysbiosisCD Yes 0.770769798460021 0.344845365783288 803 436 0.0257862734075708 0.254925265695272 +PWY_5100_pyruvate_fermentation_to_acetate__lactate_II diagnosis UC 0.466926220101608 0.206233023076628 803 778 0.0259835543686192 0.254925265695272 +TCA_TCA_cyc_I diagnosis CD -0.728239633244926 0.323638453064422 803 412 0.0266802684976624 0.259715738656932 +UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I age age -0.369441643165609 0.149383423639206 803 503 0.0269678450095815 0.260480115363865 +PWY_5695_urate_biosyn_inosine_5_phosphate_deg antibiotics Yes 0.20094912854232 0.0908539724433417 803 800 0.0272797004720908 0.261465436832501 +PWY0_1586_peptidoglycan_maturation dysbiosisCD Yes 0.607070869849979 0.274817238077764 803 773 0.0276009565016741 0.262525128252564 +PWY_7388_octanoyl_acyl_carrier_protein_biosyn age age -0.568332199950919 0.167050410279971 803 535 0.0279295857929499 0.263229959330827 +GALACTUROCAT_PWY_D_galacturonate_deg_I age age -0.242765023539532 0.104976286933503 803 776 0.0280975799285714 0.263229959330827 +PWY_5973_cis_vaccenate_biosyn dysbiosisCD Yes -0.386481239864996 0.176057001158609 803 787 0.0284745710884194 0.264771011762467 +TRNA_CHARGING_PWY_tRNA_charging age age 0.284255109358554 0.128085823864683 803 703 0.0287696649134785 0.265533351719957 +PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I diagnosis CD 0.326942214334394 0.147933616465445 803 792 0.0292987869221212 0.268087939628895 +PWY_4981_L_proline_biosyn_II dysbiosisnonIBD Yes 1.58387467656411 0.726144772898054 803 678 0.0294767638275751 0.268087939628895 +PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn age age -0.239376924069279 0.108764056060188 803 469 0.0300372361049261 0.270407613851574 +PWY_7219_adenosine_rnt_de_novo_biosyn dysbiosisCD Yes 0.141450336531592 0.0652375382357765 803 803 0.0305096322805757 0.270407613851574 +PWY_841_SP_of_purine_nt_de_novo_biosyn_I age age -0.289988223831717 0.131805060954878 803 651 0.0305254778380127 0.270407613851574 +PWY_7220_adenosine_dnt_de_novo_biosyn_II diagnosis UC 0.422628206007962 0.192846834375227 803 783 0.0309393191613248 0.270407613851574 +PWY_7222_guanosine_dnt_de_novo_biosyn_II diagnosis UC 0.422628206007962 0.192846834375227 803 783 0.0309393191613248 0.270407613851574 +PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II age age -0.144210377297358 0.0658959263419306 803 769 0.0311883648728672 0.270407613851574 +ARO_PWY_chorismate_biosyn_I diagnosis UC -0.429151433232175 0.196811192529694 803 775 0.0314206035157391 0.270407613851574 +COA_PWY_coenzyme_A_biosyn_I diagnosis CD 0.502138839892677 0.229969865343506 803 774 0.0314679807451671 0.270407613851574 +PWY_5030_L_histidine_deg_III diagnosis UC -1.38665161732442 0.637429087182279 803 542 0.0320203945735826 0.273269942730712 +PWY_841_SP_of_purine_nt_de_novo_biosyn_I diagnosis UC -0.799638913601274 0.368892644312092 803 651 0.0327008553528982 0.27589376683764 +PWY_7208_SP_of_pyrimidine_nucleobases_salvage dysbiosisUC Yes 0.480939346903681 0.225142136875948 803 794 0.0329880112369833 0.27589376683764 +PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I dysbiosisUC Yes -0.884218190559592 0.413933755700609 803 765 0.0329921117646937 0.27589376683764 +PWY_6317_galactose_deg_I diagnosis CD 0.492224290324306 0.228471972144252 803 765 0.0334884920899744 0.278177740960721 +GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg dysbiosisUC Yes 0.880798376202179 0.416081639054914 803 745 0.0345933367165203 0.284327589492791 +PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I dysbiosisCD Yes -0.542893578251185 0.256513542735847 803 765 0.0346852276106776 0.284327589492791 +HISDEG_PWY_L_histidine_deg_I age age 0.632418080649578 0.296312276094613 803 582 0.0352715684367181 0.287244276288567 +PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II diagnosis UC 0.377352289203574 0.177058448055262 803 783 0.0358150602172927 0.28977639630355 +PWY_5173_SP_of_acetyl_CoA_biosyn dysbiosisnonIBD Yes 1.73645412574839 0.82746778526519 803 335 0.0364393089837077 0.292925025765805 +PWY66_422_D_galactose_deg_V diagnosis CD 0.437795245718275 0.206788120729633 803 785 0.0366791495040012 0.292962950525548 +PWY_6270_isoprene_biosyn_I antibiotics Yes -0.867137160950265 0.415424367650501 803 219 0.0372791096103434 0.295223826976604 +PWY_2941_L_lysine_biosyn_II diagnosis UC -1.08924716352517 0.515993312284858 803 454 0.0374360872089112 0.295223826976604 +GLYOXYLATE_BYPASS_glyoxylate_cyc dysbiosisCD Yes 1.47984350083374 0.711853150993553 803 255 0.0382194977344945 0.299506252686668 +PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I diagnosis UC 0.520528886599544 0.248471994839435 803 762 0.0385933189314519 0.299939829468484 +PWY_2942_L_lysine_biosyn_III age age 0.0654122118374606 0.031237265618287 803 802 0.0390758246366115 0.299939829468484 +PWY_5188_tetrapyrrole_biosyn_I age age -0.273648679961853 0.130829374054935 803 731 0.0391009898209767 0.299939829468484 +PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I diagnosis CD -0.465490413715833 0.223323955926266 803 764 0.0392377144489269 0.299939829468484 +X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn age age 0.146520219477133 0.0703910504326103 803 779 0.0397633659292672 0.300273660290103 +PENTOSE_P_PWY_pentose_phosphate_pwy diagnosis UC -0.812412898973906 0.384004427680844 803 613 0.0396869984931422 0.300273660290103 +PWY_6969_TCA_cyc_V antibiotics Yes -0.841028261817053 0.409836472259684 803 403 0.0405521745543258 0.304385599365602 +PWY_4242_pantothenate__coenzyme_A_biosyn_III diagnosis UC 0.78278970501465 0.377731822676939 803 725 0.0409491371935333 0.305524700258338 +PWY66_400_glycolysis_VI diagnosis UC 0.256844074262945 0.124508192359146 803 789 0.0414198041624311 0.3069506973159 +FUCCAT_PWY_fucose_deg diagnosis CD -0.871850618497609 0.423297890119225 803 268 0.0416329597483042 0.3069506973159 +PWY_6124_inosine_5_phosphate_biosyn_II diagnosis UC 0.357376069464289 0.173463614745037 803 792 0.0421205931613465 0.307712733279471 +PWY_7184_pyrimidine_dnt_de_novo_biosyn_I age age -0.154670060341955 0.0751070467534596 803 747 0.0422302386763961 0.307712733279471 +SALVADEHYPOX_PWY_adenosine_nt_deg_II age age -0.445443289494601 0.209303515170423 803 638 0.0426658146972513 0.308841788796512 +PWY_7111_pyruvate_fermentation_to_isobutanol dysbiosisnonIBD Yes 0.337856585415397 0.166592665016173 803 801 0.042918691000273 0.308841788796512 +PWY_5154_L_arginine_biosyn_III diagnosis UC 0.718823289263681 0.352064974340705 803 475 0.0436245223340178 0.308841788796512 +PWY_6545_pyrimidine_dnt_de_novo_biosyn_III antibiotics Yes -0.533672290071839 0.263792010914794 803 651 0.0434274620677704 0.308841788796512 +PWY_7234_inosine_5_phosphate_biosyn_III dysbiosisCD Yes -0.667012191562121 0.329806069605906 803 690 0.0435586055582039 0.308841788796512 +GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg dysbiosisUC Yes 0.794799535635938 0.395028688028806 803 755 0.0445703904077824 0.313755403661564 +COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn diagnosis CD -0.329566915390045 0.162601396576071 803 773 0.0448995375488439 0.314296762841907 +GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg antibiotics Yes -0.499093905705791 0.249488375280911 803 745 0.0458194937011907 0.314954174317282 +PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisnonIBD Yes -1.04976083247691 0.524656365253918 803 469 0.0458373504954304 0.314954174317282 +PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn antibiotics Yes -0.404554750069997 0.202199802292024 803 742 0.0457949876423238 0.314954174317282 +PWY_6527_stachyose_deg diagnosis CD 0.482619658141226 0.239388576223493 803 766 0.0464115939173484 0.314954174317282 +COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn diagnosis UC -0.353604327202692 0.176058268829741 803 773 0.0470486946627209 0.314954174317282 +PWY_7220_adenosine_dnt_de_novo_biosyn_II age age -0.180990025990024 0.0769440875676632 803 783 0.0471336677105022 0.314954174317282 +PWY_7222_guanosine_dnt_de_novo_biosyn_II age age -0.180990025990024 0.0769440875676632 803 783 0.0471336677105022 0.314954174317282 +UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I dysbiosisnonIBD Yes 1.19836091080269 0.60149984095373 803 503 0.0468559906426255 0.314954174317282 +PWY_1042_glycolysis_IV dysbiosisUC Yes 0.236253145724787 0.118890626562212 803 803 0.0472684033686451 0.314954174317282 +PWY_6936_seleno_amino_acid_biosyn dysbiosisCD Yes 0.888513934808618 0.447908888574056 803 472 0.0478274253717766 0.316983893687413 +PWY66_422_D_galactose_deg_V diagnosis UC 0.446641488889928 0.22389795248501 803 785 0.0488767936557938 0.319758295802711 +PYRIDNUCSYN_PWY_NAD_biosyn_I dysbiosisnonIBD Yes -0.964732238648902 0.489240338917567 803 707 0.0489983074567456 0.319758295802711 +PWY_6168_flavin_biosyn_III antibiotics Yes -0.328001088706479 0.1664871578073 803 760 0.0491986380562224 0.319758295802711 +PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn diagnosis UC -0.411085874433866 0.20668243864786 803 761 0.0492725463837243 0.319758295802711 +PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisUC Yes -0.673493921867072 0.343073314906315 803 742 0.0499957748795693 0.322770650258774 +PWY_5686_UMP_biosyn age age 0.0662602416266843 0.0334890060367593 803 802 0.050877027480262 0.326277685457918 +GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg dysbiosisUC Yes -0.748256646526601 0.383932703299744 803 757 0.0516712686849266 0.326277685457918 +PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II age age -0.160956734677839 0.0700593169624207 803 783 0.0517186724121492 0.326277685457918 +GALACTUROCAT_PWY_D_galacturonate_deg_I dysbiosisCD Yes 0.412428057714626 0.212084903132354 803 776 0.0523449475437791 0.326277685457918 +PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I dysbiosisUC Yes -0.818461451333869 0.421212239615783 803 764 0.0523720201377076 0.326277685457918 +PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II dysbiosisCD Yes -0.205581867811983 0.105618757284973 803 794 0.0520035995057454 0.326277685457918 +PWY0_1296_purine_rns_deg diagnosis CD 0.347801118877879 0.177229535374546 803 793 0.0521989189785734 0.326277685457918 +PWYG_321_mycolate_biosyn antibiotics Yes -0.880877274427977 0.455295790177938 803 484 0.0534529105179112 0.330492280872038 +PWY66_400_glycolysis_VI age age 0.0867835080947964 0.0444522548283265 803 789 0.0536353318466375 0.330492280872038 +FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation dysbiosisUC Yes -1.34359434465991 0.695657719501739 803 539 0.0538442480072422 0.330492280872038 +ARGSYN_PWY_L_arginine_biosyn_I diagnosis UC 0.596453848409813 0.307111661395693 803 495 0.0547181097341677 0.332403348785429 +PWY_7400_L_arginine_biosyn_IV diagnosis UC 0.583599046782014 0.300799864021307 803 495 0.0549559308585861 0.332403348785429 +PWY_7664_oleate_biosyn_IV dysbiosisUC Yes -1.37086182915663 0.711885004487613 803 531 0.0545556771031158 0.332403348785429 +PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg age age -0.280258504819591 0.139918689378591 803 757 0.0572690925469737 0.340611457162117 +PWY_6609_adenine__adenosine_salvage_III age age 0.147751671005196 0.0746790099785235 803 792 0.0574248483323962 0.340611457162117 +PWY_7237_myo__chiro__scillo_inositol_deg diagnosis UC 0.941050335144392 0.488648967563151 803 441 0.0570865638551937 0.340611457162117 +PWY4FS_7_phosphatidylglycerol_biosyn_I dysbiosisCD Yes 0.803500733319756 0.422213468344555 803 604 0.0576797892947084 0.340611457162117 +PWY4FS_8_phosphatidylglycerol_biosyn_II dysbiosisCD Yes 0.803503428186978 0.422213554661398 803 604 0.0576790046934593 0.340611457162117 +PWY_6163_chorismate_biosyn_from_3_dehydroquinate diagnosis CD -0.383690935934444 0.200959378309068 803 787 0.058923450311031 0.344688352523684 +PWY_7184_pyrimidine_dnt_de_novo_biosyn_I antibiotics Yes -0.405428826190754 0.214243729517023 803 747 0.0588440926137721 0.344688352523684 +PWY0_1586_peptidoglycan_maturation age age -0.18905730599469 0.0993541623920039 803 773 0.0601084661127129 0.348349529192745 +PWY66_409_SP_of_purine_nt_salvage dysbiosisUC Yes 1.17277187239909 0.622740340098277 803 290 0.060076516172732 0.348349529192745 +COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I antibiotics Yes 0.550722914334953 0.293387728468764 803 578 0.0608870136494518 0.349561718264402 +PWY4FS_7_phosphatidylglycerol_biosyn_I diagnosis UC -0.730582782819252 0.385988817765962 803 604 0.0612237563180839 0.349561718264402 +PWY4FS_8_phosphatidylglycerol_biosyn_II diagnosis UC -0.73058230771846 0.385988961078921 803 604 0.0612240159946197 0.349561718264402 +PWY_4242_pantothenate__coenzyme_A_biosyn_III diagnosis CD 0.657727808813189 0.348201015212371 803 725 0.0618617086503273 0.349561718264402 +PWY_7196_SP_of_pyrimidine_rns_salvage age age -0.26002092142094 0.1376222201618 803 411 0.0618162792092238 0.349561718264402 +FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation dysbiosisCD Yes 0.827278433597985 0.442370120200398 803 539 0.0620640585942604 0.349561718264402 +GLYOXYLATE_BYPASS_glyoxylate_cyc dysbiosisnonIBD Yes 2.22807156592999 1.19382313459855 803 255 0.0626658405628266 0.349561718264402 +PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn age age -0.134542660490961 0.0715108395116825 803 742 0.0632047769770032 0.349561718264402 +TCA_TCA_cyc_I diagnosis UC -0.659361947279675 0.350901674338009 803 412 0.06327507702678 0.349561718264402 +P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate age age -0.351218712195342 0.18704548146417 803 283 0.0636640364083218 0.349561718264402 +PWY_6282_palmitoleate_biosyn_I dysbiosisUC Yes -1.33495919510047 0.71866038462981 803 531 0.0636569430736797 0.349561718264402 +PWY_6353_purine_nt_deg_II diagnosis UC -0.752476456340085 0.401042552695759 803 432 0.0640453111640903 0.349561718264402 +PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II diagnosis UC -0.166112645372482 0.0887075285042546 803 798 0.0639275439138928 0.349561718264402 +PWY_7184_pyrimidine_dnt_de_novo_biosyn_I dysbiosisCD Yes -0.405002656970382 0.218369135495037 803 747 0.064245291719541 0.349561718264402 +PWY_7383_anaerobic_energy_metabolism diagnosis UC -0.682055612659967 0.364997534736546 803 698 0.0647538463015767 0.349756564673144 +PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I diagnosis CD -0.672242941166836 0.360851742940487 803 557 0.0650666478568358 0.349756564673144 +PWY_5100_pyruvate_fermentation_to_acetate__lactate_II dysbiosisCD Yes 0.407460846402485 0.220354198564196 803 778 0.0651232126839241 0.349756564673144 +ARO_PWY_chorismate_biosyn_I diagnosis CD -0.336609512318507 0.181432781974111 803 775 0.0661103998336456 0.353534584518122 +ANAGLYCOLYSIS_PWY_glycolysis_III dysbiosisUC Yes -0.224693704500924 0.12260887447181 803 801 0.0672508080784535 0.356572369641502 +PWY_6608_guanosine_nt_deg_III antibiotics Yes -0.604639500479134 0.329880077532769 803 686 0.0672362149479365 0.356572369641502 +PWY_6901_SP_of_glucose__xylose_deg age age -0.244359259629681 0.133187403375825 803 436 0.0700100713776148 0.36962944464622 +PWY_7242_D_fructuronate_deg dysbiosisCD Yes 0.374527681744849 0.206960595778553 803 773 0.0708550113702466 0.372512000706022 +DAPLYSINESYN_PWY_L_lysine_biosyn_I diagnosis CD -0.515637328872997 0.28356285376083 803 595 0.0716852086166323 0.374489025515911 +GALACTUROCAT_PWY_D_galacturonate_deg_I dysbiosisUC Yes 0.597691663969731 0.331556323998759 803 776 0.0718321646053793 0.374489025515911 +FASYN_ELONG_PWY_fatty_acid_elongation__saturated dysbiosisUC Yes -1.26892121857639 0.705106243963167 803 532 0.0723579897623117 0.375658563516002 +PWY_5659_GDP_mannose_biosyn dysbiosisUC Yes 0.543966945326156 0.30329239730272 803 788 0.0732912998767553 0.375735294386728 +ARGSYNBSUB_PWY_L_arginine_biosyn_II diagnosis UC 0.936222323550252 0.518523121649978 803 428 0.0739449287324628 0.375735294386728 +NONOXIPENT_PWY_pentose_phosphate_pwy dysbiosisCD Yes -0.229253645252788 0.128213149851631 803 800 0.0741936321490204 0.375735294386728 +PWY_7220_adenosine_dnt_de_novo_biosyn_II dysbiosisCD Yes 0.359096686883806 0.200854564026025 803 783 0.0744460189286343 0.375735294386728 +PWY_7222_guanosine_dnt_de_novo_biosyn_II dysbiosisCD Yes 0.359096686883806 0.200854564026025 803 783 0.0744460189286343 0.375735294386728 +PWY_7237_myo__chiro__scillo_inositol_deg diagnosis CD 0.814459712957953 0.45211031538734 803 441 0.0744836418246564 0.375735294386728 +PWY_7388_octanoyl_acyl_carrier_protein_biosyn dysbiosisUC Yes -1.26539242219935 0.707190081788768 803 535 0.0740021062408363 0.375735294386728 +PWY_7184_pyrimidine_dnt_de_novo_biosyn_I dysbiosisUC Yes -0.646126564847276 0.362487127471438 803 747 0.0750688325520215 0.377160344192818 +PWY66_399_gluconeogenesis_III diagnosis UC -0.870313560420373 0.484602402975874 803 670 0.0755575796971147 0.378091342580743 +PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II diagnosis CD 0.295214695987338 0.164824376124113 803 783 0.0764248538263697 0.380901471470627 +PWY_7220_adenosine_dnt_de_novo_biosyn_II diagnosis CD 0.31941509587717 0.179288650910903 803 783 0.0779107113157016 0.384453907703014 +PWY_7222_guanosine_dnt_de_novo_biosyn_II diagnosis CD 0.31941509587717 0.179288650910903 803 783 0.0779107113157016 0.384453907703014 +PWY_6737_starch_deg_V age age -0.121606449751512 0.0683562573952239 803 800 0.0782370241752156 0.384453907703014 +PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I dysbiosisCD Yes -0.444849568066423 0.253326370932583 803 764 0.079717456834968 0.384453907703014 +PWY_5913_TCA_cyc_VI dysbiosisUC Yes 1.71255639463176 0.972753778723908 803 146 0.0790246384002566 0.384453907703014 +PWY_5989_stearate_biosyn_II dysbiosisUC Yes -1.20328882422033 0.685414062221238 803 575 0.0795728170878349 0.384453907703014 +PWY_6608_guanosine_nt_deg_III dysbiosisUC Yes -0.994338804333338 0.565770711485847 803 686 0.07923925555117 0.384453907703014 +PWY66_409_SP_of_purine_nt_salvage age age -0.215234561549027 0.121572936808188 803 290 0.0795943632433755 0.384453907703014 +PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn dysbiosisnonIBD Yes -0.566583355075511 0.323069434702288 803 761 0.0799145763202894 0.384453907703014 +PWY_4984_urea_cyc diagnosis CD -0.743284539700725 0.420892081520955 803 665 0.0807495063176103 0.38615864079927 +PWY_7560_methylerythritol_phosphate_pwy_II antibiotics Yes -0.734959140418942 0.420341063695186 803 226 0.0808887682573109 0.38615864079927 +PWY_7234_inosine_5_phosphate_biosyn_III antibiotics Yes -0.541450953990253 0.310512612959677 803 690 0.0816193943869418 0.388159409947059 +PWY_5177_glutaryl_CoA_deg age age -0.272968291059096 0.148898862179221 803 753 0.0824515660456849 0.390626050543435 +PWY_7242_D_fructuronate_deg antibiotics Yes -0.32824034553539 0.189358648309062 803 773 0.0834346540012325 0.390825484532089 +PWY0_862_dodec_5_enoate_biosyn dysbiosisUC Yes -1.22769059421624 0.707868058220264 803 546 0.0833005004661907 0.390825484532089 +PYRIDNUCSYN_PWY_NAD_biosyn_I antibiotics Yes -0.497730864193354 0.286949964439834 803 707 0.0832340044619888 0.390825484532089 +FUCCAT_PWY_fucose_deg diagnosis UC -0.81718256174911 0.469033632550966 803 268 0.0842858545310342 0.39118251612777 +PWY_5188_tetrapyrrole_biosyn_I antibiotics Yes 0.5055658911605 0.292628625535411 803 731 0.0844527261945185 0.39118251612777 +PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn antibiotics Yes 0.513677820805601 0.297013060268844 803 604 0.0841417746890917 0.39118251612777 +PWY_7196_SP_of_pyrimidine_rns_salvage dysbiosisnonIBD Yes -1.07449572304174 0.622883352209088 803 411 0.0850126417150446 0.392317598433132 +P108_PWY_pyruvate_fermentation_to_propanoate_I dysbiosisUC Yes -1.67085620841024 0.969886171699741 803 350 0.0855733017338238 0.392334607659174 +PWY0_862_dodec_5_enoate_biosyn antibiotics Yes -0.720976111101673 0.418853006080081 803 546 0.0856460780764811 0.392334607659174 +PWY_5030_L_histidine_deg_III dysbiosisCD Yes -0.800486137707702 0.467405681361447 803 542 0.0872120305773036 0.394714889783194 +PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg dysbiosisUC Yes 0.745322016330121 0.435437408810239 803 757 0.0873663980983596 0.394714889783194 +PWY_7197_pyrimidine_dnt_phosphorylation dysbiosisnonIBD Yes -0.731344617843348 0.427151402942051 803 751 0.0872881339676921 0.394714889783194 +PWY66_422_D_galactose_deg_V dysbiosisnonIBD Yes 0.548667495851078 0.320624142342684 803 785 0.0874583933312284 0.394714889783194 +PWY_6151_S_adenosyl_L_methionine_cyc_I dysbiosisnonIBD Yes 0.380261737375445 0.222429871617898 803 791 0.0877496183546908 0.394714889783194 +RIBOSYN2_PWY_flavin_biosyn_I diagnosis UC -0.777033013853754 0.451141803114087 803 478 0.0882315726158049 0.395455177983068 +PWY_6700_queuosine_biosyn diagnosis CD 0.339617940262209 0.197689140240562 803 780 0.0886222956266954 0.395782725271908 +PWY_5103_L_isoleucine_biosyn_III age age 0.139103665396227 0.0811928129546069 803 778 0.0898022006665567 0.399302221527074 +CALVIN_PWY_Calvin_Benson_Bassham_cyc diagnosis UC -0.228025538458575 0.133213012889038 803 797 0.0900513035707126 0.399302221527074 +PWY66_399_gluconeogenesis_III dysbiosisCD Yes -0.822084294806453 0.486788915862611 803 670 0.0917581867583135 0.404943555606442 +TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA diagnosis CD -0.887802171100276 0.520103966728718 803 159 0.0919735363054761 0.404943555606442 +P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate dysbiosisUC Yes 1.39781206339822 0.830772545047593 803 283 0.0928968184775782 0.407568435996699 +PWY_5989_stearate_biosyn_II age age -0.427639348134857 0.177600948190725 803 575 0.0933925935541672 0.408305865152605 +GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff dysbiosisUC Yes 1.21236167544489 0.728592270053511 803 412 0.0965526227894022 0.418274656564356 +PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn age age -0.240575642408239 0.1432896646212 803 281 0.0963816737099807 0.418274656564356 +OANTIGEN_PWY_O_antigen_building_blocks_biosyn age age -0.264115549873261 0.145218036468676 803 445 0.0979796565556634 0.418274656564356 +PWY_5173_SP_of_acetyl_CoA_biosyn antibiotics Yes 0.97174180808444 0.585656290386701 803 335 0.0977543047763601 0.418274656564356 +PWY_6317_galactose_deg_I diagnosis UC 0.411465417317855 0.246320675575618 803 765 0.0980226321964623 0.418274656564356 +PWY66_399_gluconeogenesis_III dysbiosisUC Yes -1.26524429850833 0.763362645344227 803 670 0.0978744117804549 0.418274656564356 +VALSYN_PWY_L_valine_biosyn dysbiosisCD Yes 0.172909163183398 0.10415778517292 803 802 0.0974410447495855 0.418274656564356 +NONOXIPENT_PWY_pentose_phosphate_pwy age age 0.0972191812051782 0.0583108301965673 803 800 0.0988041515085112 0.418741404012262 +PWY_621_sucrose_deg_III dysbiosisnonIBD Yes -0.821835185661368 0.4971625974731 803 741 0.0987753524213241 0.418741404012262 +PWY_5484_glycolysis_II antibiotics Yes -0.213388398963083 0.129278425931598 803 791 0.0992593973986359 0.419244776809154 +PWY_7456_mannan_deg diagnosis CD -0.570180600061109 0.345482191373458 803 210 0.102093925835861 0.429760241863118 +PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I diagnosis UC -0.27722072908882 0.16811059970718 803 783 0.102740117219609 0.430761060764503 +PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I dysbiosisCD Yes -0.355677667959276 0.217969241590973 803 762 0.103222761303666 0.430761060764503 +OANTIGEN_PWY_O_antigen_building_blocks_biosyn antibiotics Yes -0.562100691701864 0.344739925111575 803 445 0.103442457707873 0.430761060764503 +PWY_7221_guanosine_rnt_de_novo_biosyn dysbiosisCD Yes -0.115422218563807 0.0708827400255546 803 802 0.103894742734547 0.430761060764503 +SALVADEHYPOX_PWY_adenosine_nt_deg_II diagnosis UC 0.66810672076395 0.407294158816144 803 638 0.104060256252099 0.430761060764503 +PWY_6609_adenine__adenosine_salvage_III dysbiosisUC Yes -0.369757771214826 0.228404939813491 803 792 0.105889509909823 0.434010962544981 +PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn dysbiosisnonIBD Yes -1.34764814190004 0.832336798127832 803 504 0.105890315099257 0.434010962544981 +PWY0_1479_tRNA_processing dysbiosisUC Yes -1.17276413278015 0.723946923046175 803 414 0.105817246444975 0.434010962544981 +PWY_1042_glycolysis_IV dysbiosisnonIBD Yes -0.205074315067198 0.126800430191743 803 803 0.106238876910535 0.43401193649353 +PWY_5695_urate_biosyn_inosine_5_phosphate_deg diagnosis UC 0.167800397286793 0.103092862923217 803 800 0.106797173286726 0.434866921291701 +PWY_6608_guanosine_nt_deg_III diagnosis CD 0.519338865142696 0.319873737243408 803 686 0.107478743150333 0.436216657867475 +NONOXIPENT_PWY_pentose_phosphate_pwy diagnosis CD 0.237211008562327 0.146285231834055 803 800 0.107886942531308 0.436232569379491 +PWY_6353_purine_nt_deg_II antibiotics Yes -0.643621337078533 0.400147156725375 803 432 0.108182876354946 0.436232569379491 +PWY_5484_glycolysis_II dysbiosisCD Yes -0.212323223663752 0.132497216194874 803 791 0.109674678664361 0.437934628389616 +PWY_6270_isoprene_biosyn_I diagnosis CD -0.737736849105684 0.458312067491592 803 219 0.110190809451977 0.437934628389616 +PWY_6545_pyrimidine_dnt_de_novo_biosyn_III diagnosis CD -0.432093047472938 0.268442519274811 803 651 0.110147222655623 0.437934628389616 +PWY_7196_SP_of_pyrimidine_rns_salvage antibiotics Yes -0.63154194779815 0.394789649242851 803 411 0.11011316344378 0.437934628389616 +PWY_5913_TCA_cyc_VI antibiotics Yes 0.999017743183287 0.625053788412674 803 146 0.110705722309354 0.437934628389616 +PWY_5083_NAD_NADH_phosphorylation__dephosphorylation dysbiosisnonIBD Yes 1.17534459665727 0.736321269009047 803 431 0.111012387380955 0.437934628389616 +DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I dysbiosisCD Yes -0.216341847441251 0.136958305574997 803 790 0.114706151498946 0.437934628389616 +FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation antibiotics Yes -0.653153422026126 0.413214584661976 803 539 0.114419402269941 0.437934628389616 +GLYCOLYSIS_glycolysis_I antibiotics Yes -0.204902026161944 0.129026383224621 803 791 0.112706580928118 0.437934628389616 +PWY_5686_UMP_biosyn dysbiosisUC Yes 0.182529304169682 0.115382363823005 803 802 0.114088755932618 0.437934628389616 +PWY_6151_S_adenosyl_L_methionine_cyc_I diagnosis CD -0.254858902591393 0.159804550014133 803 791 0.113685406130363 0.437934628389616 +PWY_6969_TCA_cyc_V dysbiosisnonIBD Yes 1.03323809329553 0.651781564378757 803 403 0.113507657486203 0.437934628389616 +PWY_7197_pyrimidine_dnt_phosphorylation antibiotics Yes -0.386187074657449 0.244007399260591 803 751 0.11391119274118 0.437934628389616 +PWY_7237_myo__chiro__scillo_inositol_deg dysbiosisnonIBD Yes 1.34214000539112 0.846241169437433 803 441 0.113302076118933 0.437934628389616 +PWY_7242_D_fructuronate_deg age age -0.174346058411165 0.105394860281677 803 773 0.113934942642555 0.437934628389616 +PWY0_1261_anhydromuropeptides_recycling age age -0.281254838991769 0.176408731260798 803 273 0.114735920728087 0.437934628389616 +TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA dysbiosisCD Yes 0.777409983579047 0.48979071942078 803 159 0.113307079471997 0.437934628389616 +PWY_7187_pyrimidine_dnt_de_novo_biosyn_II dysbiosisCD Yes 0.526788934161913 0.333813686963079 803 647 0.115059124586663 0.437934628389616 +PWY_5177_glutaryl_CoA_deg dysbiosisCD Yes -0.489653217259841 0.310487291880916 803 753 0.11529641470621 0.437934628389616 +DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I dysbiosisUC Yes -0.318612411599356 0.202319786898348 803 790 0.115719905469085 0.437934628389616 +PWY_6124_inosine_5_phosphate_biosyn_II diagnosis CD 0.252778496554477 0.159452485578676 803 792 0.115985896764505 0.437934628389616 +PWY_7221_guanosine_rnt_de_novo_biosyn dysbiosisnonIBD Yes 0.179580981278904 0.114599101435134 803 802 0.117520217219373 0.442387282946643 +ARO_PWY_chorismate_biosyn_I dysbiosisnonIBD Yes -0.474717635401628 0.303393645336154 803 775 0.118092057511348 0.443200914635963 +PWY_4242_pantothenate__coenzyme_A_biosyn_III dysbiosisCD Yes -0.52488988871819 0.336335986434299 803 725 0.119132231681914 0.445311610141944 +PWY_4041_beta_glutamyl_cyc age age -0.301322387449875 0.191001297570068 803 247 0.119446649417313 0.445311610141944 +PENTOSE_P_PWY_pentose_phosphate_pwy dysbiosisUC Yes -0.906750919169369 0.582102500970183 803 613 0.119726636755659 0.445311610141944 +PWY_5154_L_arginine_biosyn_III dysbiosisUC Yes -0.958011462108414 0.618204412458546 803 475 0.121652881298962 0.450022650558421 +PWY_6282_palmitoleate_biosyn_I dysbiosisCD Yes 0.701372814528343 0.452538038519165 803 531 0.121823487986563 0.450022650558421 +PWY0_1261_anhydromuropeptides_recycling dysbiosisUC Yes 1.16750782620271 0.754132940881464 803 273 0.122076770376201 0.450022650558421 +PWY_6385_peptidoglycan_biosyn_III dysbiosisCD Yes 0.130912250004845 0.0846986292773061 803 797 0.122745065429419 0.451151479424944 +PANTO_PWY_phosphopantothenate_biosyn_I dysbiosisUC Yes -0.261331662889528 0.169373186345625 803 798 0.123275744322211 0.451769345369044 +ANAGLYCOLYSIS_PWY_glycolysis_III diagnosis CD -0.107370687269074 0.0695324898082306 803 801 0.125031663190376 0.45556002915091 +PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I dysbiosisCD Yes -0.0930542625546036 0.0605886092337432 803 799 0.1250413563159 0.45556002915091 +PWY_5723_Rubisco_shunt dysbiosisnonIBD Yes 1.27846646153524 0.833653553777462 803 212 0.126031787152564 0.457829757411355 +PWY_6385_peptidoglycan_biosyn_III antibiotics Yes 0.122315532175277 0.0801480889056859 803 797 0.12740189979145 0.461461532384147 +P108_PWY_pyruvate_fermentation_to_propanoate_I diagnosis UC -0.60969109130028 0.397194225148928 803 350 0.128442982508871 0.463883931032038 +NAGLIPASYN_PWY_lipid_IVA_biosyn age age -0.321298716149292 0.205544087145264 803 601 0.129058188207452 0.464758677764408 +DAPLYSINESYN_PWY_L_lysine_biosyn_I age age -0.168643398870604 0.110881389993133 803 595 0.131609338754416 0.4722762569831 +PWY_5177_glutaryl_CoA_deg diagnosis UC 0.480427974515903 0.316492849968377 803 753 0.132291573373011 0.4722762569831 +PWY_6936_seleno_amino_acid_biosyn diagnosis UC -0.657019900350468 0.432962173132256 803 472 0.132078413123734 0.4722762569831 +GLYCOGENSYNTH_PWY_glycogen_biosyn_I antibiotics Yes -0.532030082207664 0.353869374945185 803 706 0.133144494174721 0.4722762569831 +GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg age age -0.265445974854594 0.175132746238302 803 300 0.13373974636947 0.4722762569831 +CALVIN_PWY_Calvin_Benson_Bassham_cyc dysbiosisCD Yes -0.177954578697324 0.118717384464062 803 797 0.134336303576023 0.4722762569831 +P108_PWY_pyruvate_fermentation_to_propanoate_I dysbiosisnonIBD Yes -1.14705255780545 0.765855194952385 803 350 0.134863904835497 0.4722762569831 +PWY_7456_mannan_deg antibiotics Yes -0.504225688688303 0.336583136820967 803 210 0.134711851943664 0.4722762569831 +PWY0_1479_tRNA_processing dysbiosisCD Yes 0.718166438720932 0.479310806959755 803 414 0.134712308551886 0.4722762569831 +PWY_3841_folate_transformations_II dysbiosisCD Yes -0.213928302652555 0.143464712683136 803 787 0.13640296461077 0.4722762569831 +PWY_5667_CDP_diacylglycerol_biosyn_I dysbiosisCD Yes -0.132998962165015 0.0892962738222802 803 801 0.136831242994301 0.4722762569831 +PWY_5913_TCA_cyc_VI dysbiosisCD Yes 0.778628309332424 0.520763332884927 803 146 0.135717152182496 0.4722762569831 +PWY_6317_galactose_deg_I dysbiosisnonIBD Yes 0.562378387625704 0.377196182550281 803 765 0.136430842503851 0.4722762569831 +PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I diagnosis CD -0.233622297802566 0.155559937848773 803 783 0.13657378012136 0.4722762569831 +PWY0_1319_CDP_diacylglycerol_biosyn_II dysbiosisCD Yes -0.133059727863094 0.0892955302456486 803 801 0.136649027975801 0.4722762569831 +RHAMCAT_PWY_L_rhamnose_deg_I dysbiosisCD Yes 0.513831815738575 0.346148014178519 803 709 0.138155978795741 0.47553135242954 +PWY_6703_preQ0_biosyn dysbiosisCD Yes -0.339438412282958 0.228861082668212 803 771 0.138602443948658 0.475612417073658 +PWY_5659_GDP_mannose_biosyn dysbiosisCD Yes -0.29853419531563 0.201508631962907 803 788 0.138942953302417 0.475612417073658 +PANTO_PWY_phosphopantothenate_biosyn_I dysbiosisnonIBD Yes -0.269302734406945 0.183060698564594 803 798 0.141673425861195 0.479999761638004 +PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II dysbiosisCD Yes 0.275048128482761 0.186923650045594 803 783 0.141868836190632 0.479999761638004 +PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine dysbiosisnonIBD Yes 0.849966948517775 0.577219845423055 803 597 0.141390198349667 0.479999761638004 +DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I antibiotics Yes 0.181983732856199 0.123899814287459 803 790 0.14230856439129 0.479999761638004 +P42_PWY_incomplete_reductive_TCA_cyc diagnosis UC 0.535130909911449 0.36231938563879 803 636 0.142624115890742 0.479999761638004 +PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I diagnosis CD 0.33793061070678 0.228882117278911 803 762 0.14273586486735 0.479999761638004 +PWY_5097_L_lysine_biosyn_VI age age -0.0674687750052345 0.0446980976708693 803 802 0.142921277341653 0.479999761638004 +GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg dysbiosisCD Yes 0.393712725989982 0.269347556022556 803 745 0.14440418845216 0.482525484733544 +GLYCOGENSYNTH_PWY_glycogen_biosyn_I age age -0.239750643627375 0.151804657849742 803 706 0.145242404691278 0.482525484733544 +PWY_2941_L_lysine_biosyn_II antibiotics Yes -0.507581579646747 0.348393587348559 803 454 0.145609616580909 0.482525484733544 +PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine age age -0.234597345358185 0.144698943756631 803 597 0.145090586294101 0.482525484733544 +PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage age age -0.141180141584616 0.0959889731303358 803 754 0.144739514585522 0.482525484733544 +PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I diagnosis CD -0.384521096025306 0.262529640809172 803 765 0.146058471375961 0.482729059242566 +PWY66_399_gluconeogenesis_III diagnosis CD -0.649745378051701 0.445371517254187 803 670 0.147560910861309 0.486404483950241 +ARGSYN_PWY_L_arginine_biosyn_I dysbiosisCD Yes 0.475936590180401 0.32941722689666 803 495 0.149170581427665 0.490413046065622 +COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn dysbiosisnonIBD Yes -0.405386157210311 0.281397013161407 803 773 0.15013577415872 0.490995208928517 +PWY_7388_octanoyl_acyl_carrier_protein_biosyn antibiotics Yes -0.603965831095949 0.419213760980705 803 535 0.15012515245993 0.490995208928517 +PWY_7197_pyrimidine_dnt_phosphorylation diagnosis UC -0.412039808912513 0.284702068363726 803 751 0.151294285976269 0.493488691954008 +PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III age age -0.356640993422732 0.234414349494768 803 512 0.15402018199956 0.499763403050656 +PWY66_400_glycolysis_VI antibiotics Yes -0.196041164611779 0.137350782234396 803 789 0.153945062209611 0.499763403050656 +DAPLYSINESYN_PWY_L_lysine_biosyn_I antibiotics Yes -0.420970608774576 0.296107157411001 803 595 0.155550469472826 0.501967356485221 +PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I age age -0.0820980553996347 0.0573519884284443 803 792 0.155907999165153 0.501967356485221 +PWY0_1297_SP_of_purine_dns_deg antibiotics Yes 0.504114359147357 0.354887194816996 803 610 0.155888187254757 0.501967356485221 +PWY_6168_flavin_biosyn_III dysbiosisUC Yes -0.402102351606196 0.283763682400036 803 760 0.156882375225303 0.503802679202906 +PWY0_1586_peptidoglycan_maturation antibiotics Yes -0.375837754409265 0.266158781738454 803 773 0.158351800964187 0.50721425193156 +GLUCONEO_PWY_gluconeogenesis_I dysbiosisUC Yes 2.09038633178112 1.4848730040535 803 457 0.159786004918818 0.509190184472755 +PWY_6700_queuosine_biosyn dysbiosisUC Yes -0.428727492357293 0.304645740681352 803 780 0.159749897487644 0.509190184472755 +PWY_6163_chorismate_biosyn_from_3_dehydroquinate dysbiosisnonIBD Yes -0.431307778712561 0.30694049975451 803 787 0.160378792669284 0.509775448127367 +PWY_5686_UMP_biosyn antibiotics Yes 0.100624360890161 0.0717618901351062 803 802 0.161262380009666 0.510115871302251 +PWY_7664_oleate_biosyn_IV dysbiosisCD Yes 0.630530183344893 0.449473628715462 803 531 0.161304697667004 0.510115871302251 +GLUCONEO_PWY_gluconeogenesis_I dysbiosisCD Yes -0.92935435424141 0.663331094020068 803 457 0.161817603619697 0.510442364835804 +PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I age age -0.300168728463246 0.175993363460755 803 561 0.164416384790107 0.517330342041599 +PWY66_409_SP_of_purine_nt_salvage antibiotics Yes -0.486882952395445 0.350237456172125 803 290 0.164945298391243 0.517616999656571 +PWY_6527_stachyose_deg dysbiosisUC Yes -0.524359631826265 0.377663682301835 803 766 0.165413792661065 0.517616999656571 +SALVADEHYPOX_PWY_adenosine_nt_deg_II diagnosis CD 0.525442731214783 0.376541598062555 803 638 0.165753758316992 0.517616999656571 +PWY_841_SP_of_purine_nt_de_novo_biosyn_I diagnosis CD -0.473225067319498 0.3395921047732 803 651 0.166492568514557 0.518079231647205 +SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I dysbiosisUC Yes 0.559729842184731 0.40447900538811 803 767 0.166824043918629 0.518079231647205 +PWY_4041_beta_glutamyl_cyc dysbiosisnonIBD Yes 1.19582972345254 0.863672778922064 803 247 0.167149158203994 0.518079231647205 +PWY_7560_methylerythritol_phosphate_pwy_II diagnosis CD -0.649681918685796 0.46870453572723 803 226 0.16841701787704 0.520713658250104 +PWY_7196_SP_of_pyrimidine_rns_salvage dysbiosisCD Yes -0.555210326402072 0.403407676491468 803 411 0.169266927774111 0.522046019818174 +COA_PWY_coenzyme_A_biosyn_I dysbiosisCD Yes -0.313846702861677 0.228590800339354 803 774 0.170286239774019 0.523892974712167 +PWY_6737_starch_deg_V dysbiosisUC Yes 0.356260926728821 0.260017185421028 803 800 0.17105025517623 0.524947334851189 +PWY_5030_L_histidine_deg_III diagnosis CD -0.800356142934055 0.581156514901238 803 542 0.171530804614575 0.525128704053465 +CITRULBIO_PWY_L_citrulline_biosyn dysbiosisnonIBD Yes -0.86361750892761 0.632497045012444 803 688 0.172551737712293 0.525574347014873 +PWY0_862_dodec_5_enoate_biosyn dysbiosisCD Yes 0.605377818399737 0.442973243844192 803 546 0.172357831624302 0.525574347014873 +PWY_6353_purine_nt_deg_II age age -0.263822096556339 0.157837918004655 803 432 0.172941799579533 0.525574347014873 +PWY_6901_SP_of_glucose__xylose_deg antibiotics Yes -0.46049070634557 0.339390606418173 803 436 0.175281441853836 0.531388507420632 +DAPLYSINESYN_PWY_L_lysine_biosyn_I dysbiosisCD Yes 0.410460452003374 0.303206842805393 803 595 0.176399501403059 0.533480045505368 +PWY0_1479_tRNA_processing antibiotics Yes 0.570588234262756 0.422071281035434 803 414 0.1769676361358 0.533902359867329 +PWY_7400_L_arginine_biosyn_IV dysbiosisCD Yes 0.433785611159928 0.322457665954493 803 495 0.179183229045674 0.538932865002376 +CALVIN_PWY_Calvin_Benson_Bassham_cyc dysbiosisUC Yes 0.228118235076116 0.169874439074785 803 797 0.179727821607584 0.538932865002376 +ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn dysbiosisUC Yes 0.407623250435909 0.303827930233889 803 732 0.180144707373988 0.538932865002376 +P108_PWY_pyruvate_fermentation_to_propanoate_I age age 0.191349760474592 0.141690385406395 803 350 0.180818267145284 0.538932865002376 +COA_PWY_1_coenzyme_A_biosyn_II diagnosis UC -0.141712359308473 0.105373580119925 803 800 0.181562545615191 0.538932865002376 +GLUCONEO_PWY_gluconeogenesis_I dysbiosisnonIBD Yes 1.29731956608722 0.969151679621844 803 457 0.181257973725392 0.538932865002376 +PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I antibiotics Yes -0.334368923848659 0.25055646274315 803 764 0.182465282554213 0.538932865002376 +PWY_6282_palmitoleate_biosyn_I antibiotics Yes -0.567228028923614 0.425217934504715 803 531 0.182659216910658 0.538932865002376 +UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I antibiotics Yes -0.50269942951006 0.376550226860518 803 503 0.182328034394535 0.538932865002376 +FASYN_ELONG_PWY_fatty_acid_elongation__saturated antibiotics Yes -0.554897183808215 0.416671551263078 803 532 0.183392885040937 0.538932865002376 +PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II antibiotics Yes -0.125991548158176 0.0946147454195752 803 794 0.183383660949229 0.538932865002376 +PWY_7664_oleate_biosyn_IV antibiotics Yes -0.560390248048223 0.421397025842265 803 531 0.184015843587612 0.539491155553328 +PWY_5676_acetyl_CoA_fermentation_to_butanoate_II diagnosis CD 0.752379401693245 0.563806738694332 803 459 0.185674456521894 0.543075992549953 +TRNA_CHARGING_PWY_tRNA_charging dysbiosisnonIBD Yes -0.695891185576509 0.526546205099715 803 703 0.186710126519726 0.544826270828053 +PWY_841_SP_of_purine_nt_de_novo_biosyn_I dysbiosisnonIBD Yes 0.821658475751619 0.622619371141528 803 651 0.187408393467687 0.545586117431631 +FASYN_ELONG_PWY_fatty_acid_elongation__saturated dysbiosisCD Yes 0.581731620661288 0.442417362644222 803 532 0.189178388389559 0.54817737658928 +NAGLIPASYN_PWY_lipid_IVA_biosyn diagnosis CD -0.504720206905511 0.382089568392733 803 601 0.189094882152468 0.54817737658928 +PWY_5686_UMP_biosyn diagnosis UC -0.121899323949719 0.0924514943046749 803 802 0.190366155399502 0.550339279878839 +PWY_4981_L_proline_biosyn_II dysbiosisUC Yes -0.873800839674082 0.668288653842261 803 678 0.191448002257607 0.552185673178191 +PWY_7199_pyrimidine_dns_salvage dysbiosisCD Yes -0.484734837587221 0.371725750305121 803 694 0.192723202266709 0.5545799307721 +PWY_5971_palmitate_biosyn_II antibiotics Yes -0.550846305906959 0.423829800707734 803 143 0.194224524382583 0.557612344195158 +TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA dysbiosisnonIBD Yes 1.02980704321758 0.793294867180493 803 159 0.195025759807891 0.558625509702603 +PWY_7383_anaerobic_energy_metabolism age age 0.173102133018289 0.133122574641242 803 698 0.196859295743244 0.561296756283941 +THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III age age -0.191187189623797 0.139925364014954 803 682 0.196722720005616 0.561296756283941 +PWY_7197_pyrimidine_dnt_phosphorylation dysbiosisUC Yes -0.5248703086285 0.407182721109576 803 751 0.197786981145365 0.562654288829052 +GLYOXYLATE_BYPASS_glyoxylate_cyc diagnosis UC -1.05535588549894 0.816551768456957 803 255 0.199456796328321 0.56344062933204 +PWY_6151_S_adenosyl_L_methionine_cyc_I antibiotics Yes 0.163062292234364 0.127059107438625 803 791 0.199756544457746 0.56344062933204 +PWY_7388_octanoyl_acyl_carrier_protein_biosyn dysbiosisCD Yes 0.57773861491921 0.449159415126173 803 535 0.198949620327083 0.56344062933204 +SALVADEHYPOX_PWY_adenosine_nt_deg_II dysbiosisCD Yes -0.517354402704843 0.403077334535544 803 638 0.199872197564014 0.56344062933204 +DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II antibiotics Yes -0.371133131514671 0.289639026922787 803 614 0.200463958105499 0.563833164332848 +NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I dysbiosisUC Yes -0.174518983795832 0.137164504410167 803 799 0.203653168128732 0.57022887076045 +PWY0_1586_peptidoglycan_maturation dysbiosisnonIBD Yes 0.583964870176797 0.458775682562487 803 773 0.203501798162358 0.57022887076045 +ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn dysbiosisUC Yes -0.245030123059057 0.192818372609834 803 797 0.204199590226624 0.570476882112945 +NAGLIPASYN_PWY_lipid_IVA_biosyn antibiotics Yes 0.456212777508805 0.359630384553175 803 601 0.205013554917587 0.571469551291529 +GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg diagnosis CD -0.586110200127694 0.463182172853914 803 300 0.208569428915835 0.580083724172166 +PWY_5030_L_histidine_deg_III dysbiosisUC Yes -0.853626526478428 0.681819283699387 803 542 0.211003582737004 0.585546690624292 +PWY_4981_L_proline_biosyn_II antibiotics Yes -0.504635649307868 0.403634357800737 803 678 0.211603664509217 0.585907035507743 +PWY_6901_SP_of_glucose__xylose_deg dysbiosisUC Yes 0.712466024104927 0.570988104477045 803 436 0.212537283792829 0.587187262984179 +PWY_6270_isoprene_biosyn_I diagnosis UC -0.628823575307628 0.502368070645101 803 219 0.213352861989743 0.588136429290309 +THRESYN_PWY_SP_of_L_threonine_biosyn dysbiosisCD Yes 0.129209825302182 0.104130565592084 803 796 0.215057924769609 0.591361046352154 +PWY_5188_tetrapyrrole_biosyn_I diagnosis CD 0.412006004392684 0.33072283779697 803 731 0.215471841929276 0.591361046352154 +PENTOSE_P_PWY_pentose_phosphate_pwy diagnosis CD -0.442578287473596 0.352517069459204 803 613 0.216426654474532 0.592676069176411 +PWY_5971_palmitate_biosyn_II dysbiosisCD Yes 0.54690293897354 0.443814792544432 803 143 0.218548012546956 0.596306072384253 +PWY66_422_D_galactose_deg_V dysbiosisCD Yes 0.245443459102642 0.199345730707907 803 785 0.218709370047836 0.596306072384253 +PWY_7197_pyrimidine_dnt_phosphorylation diagnosis CD -0.321243759776441 0.260820458053267 803 751 0.2210939870988 0.601491502019879 +SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I age age 0.179938507214383 0.135744386053289 803 767 0.222184767113676 0.603118735654616 +PWY_6527_stachyose_deg dysbiosisCD Yes -0.299720849319852 0.245651617607441 803 766 0.222956702995692 0.603118735654616 +RIBOSYN2_PWY_flavin_biosyn_I antibiotics Yes -0.481497818897751 0.394895410123094 803 478 0.223144251313626 0.603118735654616 +PWY_5104_L_isoleucine_biosyn_IV antibiotics Yes 0.651809599457341 0.535302203578743 803 475 0.223762165526401 0.603479779753021 +SALVADEHYPOX_PWY_adenosine_nt_deg_II antibiotics Yes -0.464764904797399 0.382890476552402 803 638 0.225210251912704 0.606073377717558 +NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I dysbiosisnonIBD Yes -0.178437710843236 0.147638696361731 803 799 0.227188654061151 0.610079877069384 +PWY_7388_octanoyl_acyl_carrier_protein_biosyn diagnosis UC -0.561737186161518 0.462585942416805 803 535 0.228423700984582 0.611233241686278 +GLYOXYLATE_BYPASS_glyoxylate_cyc diagnosis CD -0.911035552329563 0.752756187417444 803 255 0.22918204602704 0.611233241686278 +MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn dysbiosisUC Yes -0.834201571845198 0.693478163958072 803 375 0.229384348198881 0.611233241686278 +PWY_6545_pyrimidine_dnt_de_novo_biosyn_III dysbiosisCD Yes -0.352431333352529 0.293047452728697 803 651 0.229580382912663 0.611233241686278 +SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I diagnosis UC -0.376307741883835 0.312765089831138 803 767 0.23198718664796 0.616324167512491 +COA_PWY_1_coenzyme_A_biosyn_II age age -0.0457979728004967 0.0381482128015595 803 800 0.232852241052544 0.616541241455445 +PWY_5659_GDP_mannose_biosyn dysbiosisnonIBD Yes 0.38624669135813 0.323632184369152 803 788 0.233058527067026 0.616541241455445 +PWY_6969_TCA_cyc_V diagnosis UC -0.440822796390246 0.367875249356289 803 403 0.233679024830849 0.616873018939063 +PWY_7234_inosine_5_phosphate_biosyn_III diagnosis UC -0.450576922047106 0.377207710327036 803 690 0.235367074384549 0.620015591296296 +X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn diagnosis CD 0.2128347203344 0.179249340072526 803 779 0.23732775835245 0.621240308628472 +PWY_5104_L_isoleucine_biosyn_IV dysbiosisnonIBD Yes -1.04478094817426 0.883116484614397 803 475 0.237203659936292 0.621240308628472 +PWY_7663_gondoate_biosyn dysbiosisCD Yes -0.188166365916061 0.158880021286094 803 792 0.236742614236308 0.621240308628472 +PWY_6122_5_aminoimidazole_rnt_biosyn_II dysbiosisUC Yes 0.192532494704862 0.163598891660152 803 799 0.239620577830283 0.623313653395684 +PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn dysbiosisUC Yes 0.192532494704862 0.163598891660152 803 799 0.239620577830283 0.623313653395684 +PWY_6609_adenine__adenosine_salvage_III diagnosis UC -0.170906403175464 0.144280000062535 803 792 0.239162097953001 0.623313653395684 +PWY_4984_urea_cyc antibiotics Yes -0.415581419697682 0.353834326420926 803 665 0.24057169758173 0.624484031639241 +METSYN_PWY_L_homoserine__L_methionine_biosyn dysbiosisUC Yes -0.778259330924877 0.66419991017776 803 375 0.241678802920469 0.626053614218096 +NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I antibiotics Yes -0.0991140785545056 0.0848552757547704 803 799 0.243156414721693 0.62857446627226 +RIBOSYN2_PWY_flavin_biosyn_I dysbiosisUC Yes -0.772833639696091 0.663789873853391 803 478 0.244715973389456 0.630010008175839 +PWY_841_SP_of_purine_nt_de_novo_biosyn_I dysbiosisUC Yes 0.709019222553343 0.609922659809089 803 651 0.245409398288772 0.630010008175839 +PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I antibiotics Yes -0.278459038072262 0.239669206299779 803 765 0.245664736644771 0.630010008175839 +PWY_7456_mannan_deg diagnosis UC -0.445885529707471 0.382052728584251 803 210 0.246041472521497 0.630010008175839 +PWY_3001_SP_of_L_isoleucine_biosyn_I dysbiosisUC Yes -0.243224886471192 0.209770201362725 803 782 0.246624422343698 0.630010008175839 +ARGSYNBSUB_PWY_L_arginine_biosyn_II dysbiosisCD Yes 0.615375443251779 0.532502806330465 803 428 0.248386256135061 0.630010008175839 +GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg age age -0.150940766071245 0.126337858696973 803 745 0.248661163255044 0.630010008175839 +P441_PWY_SP_of_N_acetylneuraminate_deg age age -0.225324945024808 0.179933528837292 803 433 0.249144229153378 0.630010008175839 +PENTOSE_P_PWY_pentose_phosphate_pwy dysbiosisnonIBD Yes -0.692672763284604 0.60071166586312 803 613 0.249273622817567 0.630010008175839 +PWY_6969_TCA_cyc_V age age 0.152810915792098 0.131336269347578 803 403 0.24775635196675 0.630010008175839 +PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage dysbiosisCD Yes -0.289518929128265 0.25053359019158 803 754 0.2482677232524 0.630010008175839 +FASYN_ELONG_PWY_fatty_acid_elongation__saturated diagnosis UC -0.520512426529049 0.45028110891262 803 532 0.250400629567356 0.631577296439121 +PWY_5347_SP_of_L_methionine_biosyn dysbiosisUC Yes -0.745444511207754 0.650557271611148 803 373 0.252219534061725 0.632623902837914 +PWY_6545_pyrimidine_dnt_de_novo_biosyn_III dysbiosisnonIBD Yes -0.52273918569903 0.456749381109441 803 651 0.252818284156376 0.632623902837914 +PWY_6897_thiamin_salvage_II dysbiosisnonIBD Yes 0.620453926781998 0.541970747326009 803 589 0.25268998796616 0.632623902837914 +PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III dysbiosisUC Yes -0.745494025953395 0.651559193049378 803 512 0.252927508442788 0.632623902837914 +PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I age age 0.0986710595169309 0.0858816674353751 803 764 0.253354195438298 0.632623902837914 +PWY0_1296_purine_rns_deg diagnosis UC 0.219766520323455 0.192460666838131 803 793 0.256151318399193 0.638329085450789 +NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I age age 0.0446532590838556 0.0393339289450277 803 799 0.259070794283759 0.643473074875665 +PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I diagnosis UC -0.0830753451505373 0.0732782420851691 803 799 0.259554166271196 0.643473074875665 +PWY_6703_preQ0_biosyn dysbiosisUC Yes -0.407618928641663 0.361703833923652 803 771 0.260122203418647 0.643473074875665 +SALVADEHYPOX_PWY_adenosine_nt_deg_II dysbiosisUC Yes -0.733897599197584 0.651591424623483 803 638 0.260391200151673 0.643473074875665 +PWY_6545_pyrimidine_dnt_de_novo_biosyn_III age age -0.162894980301649 0.139047421852592 803 651 0.260797674809158 0.643473074875665 +PWY0_1298_SP_of_pyrimidine_dns_deg age age -0.207505681719151 0.176465748671944 803 455 0.262214287125432 0.645689726795036 +GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg diagnosis CD -0.256646191281495 0.227944378319001 803 755 0.262822074417607 0.645909871251161 +PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn dysbiosisUC Yes -0.574425423226951 0.513288314686608 803 604 0.263451215702888 0.646078430494586 +GLYCOLYSIS_glycolysis_I dysbiosisnonIBD Yes 0.246010435912316 0.221115637861984 803 791 0.266298832110343 0.646078430494586 +PWY_6123_inosine_5_phosphate_biosyn_I diagnosis UC 0.147010795715155 0.131377642077415 803 794 0.265922118866116 0.646078430494586 +PWY_6897_thiamin_salvage_II age age -0.175641818412008 0.151231180995569 803 589 0.266520315629388 0.646078430494586 +PWY_7234_inosine_5_phosphate_biosyn_III dysbiosisnonIBD Yes 0.60531558425634 0.542937436331053 803 690 0.265266332278058 0.646078430494586 +PWY0_1298_SP_of_pyrimidine_dns_deg diagnosis CD -0.417575187142226 0.372663407176483 803 455 0.265131294472498 0.646078430494586 +SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I diagnosis CD -0.322123577460227 0.287871412148817 803 767 0.265953309293835 0.646078430494586 +PWY_3841_folate_transformations_II diagnosis CD 0.168481775923653 0.151099635383158 803 787 0.267051170185283 0.646108268059927 +PWY_6121_5_aminoimidazole_rnt_biosyn_I dysbiosisUC Yes 0.170909617771599 0.154721454494324 803 799 0.269670426353117 0.651180913248031 +TCA_TCA_cyc_I antibiotics Yes -0.441869161710285 0.400571312437 803 412 0.270396403212772 0.651581905622978 +PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II diagnosis CD 0.189879228577719 0.171606463645209 803 769 0.270882365258991 0.651581905622978 +FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation diagnosis UC -0.502229127699961 0.454313564093405 803 539 0.271906188519759 0.652784414057071 +PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II age age -0.0583908667800142 0.0500883543919175 803 794 0.276207691808034 0.659617640666562 +TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA diagnosis UC -0.620230287663794 0.56522224961824 803 159 0.276032652340382 0.659617640666562 +GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff diagnosis UC -0.504185854985019 0.461185400330487 803 412 0.276851731110949 0.659617640666562 +PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II antibiotics Yes -0.211302917941298 0.194600740853993 803 769 0.277928781179731 0.659617640666562 +PWYG_321_mycolate_biosyn diagnosis UC -0.49815175310948 0.455826374391052 803 484 0.277139717033734 0.659617640666562 +VALSYN_PWY_L_valine_biosyn dysbiosisnonIBD Yes 0.184288205088455 0.169721400879383 803 802 0.2779162983739 0.659617640666562 +PWY_4041_beta_glutamyl_cyc diagnosis CD -0.575535370401986 0.530203321520339 803 247 0.280365801946916 0.661983696600065 +PWY_7187_pyrimidine_dnt_de_novo_biosyn_II age age -0.174655843496873 0.146561522236133 803 647 0.280528995088503 0.661983696600065 +GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg dysbiosisCD Yes -0.267812114688078 0.248279874532658 803 757 0.281192405156021 0.661983696600065 +PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn dysbiosisCD Yes 0.416159405768764 0.386036379799756 803 281 0.281474591157192 0.661983696600065 +GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg age age -0.134879318805044 0.122604922391254 803 755 0.283527315097117 0.661983696600065 +PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I antibiotics Yes -0.21865474323594 0.203945134852851 803 762 0.284004146126913 0.661983696600065 +PWY_5097_L_lysine_biosyn_VI dysbiosisnonIBD Yes -0.144227480341707 0.134176316370462 803 802 0.282786797561891 0.661983696600065 +PWY_6527_stachyose_deg diagnosis UC 0.277809365718899 0.257968512234455 803 766 0.284238585618808 0.661983696600065 +PWY_7383_anaerobic_energy_metabolism dysbiosisCD Yes -0.443224455080786 0.413335407150402 803 698 0.284083059185111 0.661983696600065 +PWY0_1479_tRNA_processing diagnosis UC 0.544723602826597 0.505308965425885 803 414 0.284047490339247 0.661983696600065 +P105_PWY_TCA_cyc_IV antibiotics Yes -0.611384441039457 0.571235810356076 803 101 0.285220785571712 0.662010958585083 +PWY_6385_peptidoglycan_biosyn_III dysbiosisUC Yes -0.139986277308559 0.130923907714596 803 797 0.285312909117327 0.662010958585083 +METSYN_PWY_L_homoserine__L_methionine_biosyn diagnosis UC -0.421782663472898 0.395562923890693 803 375 0.288857594536322 0.666512153318995 +PWY_5484_glycolysis_II age age 0.0833218530270841 0.0564668721000027 803 791 0.28880617151783 0.666512153318995 +PWY_6608_guanosine_nt_deg_III diagnosis UC 0.369428116284648 0.346157551556807 803 686 0.288506450283727 0.666512153318995 +PWY_6123_inosine_5_phosphate_biosyn_I diagnosis CD 0.128854727020845 0.121092448173742 803 794 0.289716774751519 0.667258967357473 +SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I dysbiosisnonIBD Yes -0.455677659285086 0.431840962467962 803 767 0.291674055117806 0.670527440363074 +PWY_7234_inosine_5_phosphate_biosyn_III age age -0.165515808900501 0.145624067769698 803 690 0.292813657401615 0.671907582177555 +P108_PWY_pyruvate_fermentation_to_propanoate_I diagnosis CD -0.371418912052911 0.352515972702747 803 350 0.294911382274405 0.675477173371156 +PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn age age -0.161164264369568 0.149902098597042 803 604 0.296930074422698 0.678852977487489 +PWY0_1296_purine_rns_deg dysbiosisUC Yes -0.297316327464706 0.287051356601529 803 793 0.300643641223243 0.686084206894067 +MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn diagnosis UC -0.428447024070025 0.41294183785538 803 375 0.301969172789025 0.686498078565701 +PWY_7187_pyrimidine_dnt_de_novo_biosyn_II antibiotics Yes -0.324211988661432 0.31361654417849 803 647 0.301568283506407 0.686498078565701 +NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I diagnosis UC -0.112359844886346 0.108430473475358 803 799 0.302477885339141 0.686498078565701 +PWY_4984_urea_cyc dysbiosisnonIBD Yes -0.654996864557125 0.638683528943749 803 665 0.305447492558664 0.69175404549259 +MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn dysbiosisCD Yes 0.435767373658795 0.425198273320367 803 375 0.305904076297285 0.69175404549259 +PWY_6123_inosine_5_phosphate_biosyn_I dysbiosisUC Yes 0.195771412690041 0.191329387949232 803 794 0.306531452756177 0.691917011112675 +GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg diagnosis CD -0.247240705316139 0.242342209402776 803 745 0.310286562987962 0.698638838105423 +COA_PWY_coenzyme_A_biosyn_I antibiotics Yes -0.22022153729473 0.217560241305936 803 774 0.311752162108038 0.698638838105423 +PWY_4242_pantothenate__coenzyme_A_biosyn_III dysbiosisnonIBD Yes -0.560286162683017 0.553084360530685 803 725 0.311380978986391 0.698638838105423 +PWY_5973_cis_vaccenate_biosyn age age 0.0851619434789506 0.0795748692580208 803 787 0.311272986149431 0.698638838105423 +PWY0_1298_SP_of_pyrimidine_dns_deg antibiotics Yes -0.388705521076906 0.385717799605445 803 455 0.313921416845258 0.699724660803563 +PWY0_1479_tRNA_processing dysbiosisnonIBD Yes -0.775855837304671 0.768921111881797 803 414 0.313403992591982 0.699724660803563 +RHAMCAT_PWY_L_rhamnose_deg_I antibiotics Yes 0.321354077878699 0.318705518490577 803 709 0.31362581478594 0.699724660803563 +HISDEG_PWY_L_histidine_deg_I diagnosis CD -0.737985590957218 0.730647567181554 803 582 0.314763497309816 0.700348781514341 +PWY_6936_seleno_amino_acid_biosyn dysbiosisUC Yes -0.736108971146701 0.733718547102863 803 472 0.316055582239598 0.701970152353902 +PWY_6124_inosine_5_phosphate_biosyn_II antibiotics Yes 0.145690670134372 0.145391975681986 803 792 0.316635781086553 0.702007443476592 +GLYOXYLATE_BYPASS_glyoxylate_cyc antibiotics Yes -0.847268320151932 0.849018086962144 803 255 0.318832165781121 0.702317722500989 +PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I antibiotics Yes 0.0561859764534802 0.0563106402225386 803 799 0.318699020803522 0.702317722500989 +PWY_5083_NAD_NADH_phosphorylation__dephosphorylation dysbiosisUC Yes 0.749361821149706 0.750242338689968 803 431 0.318304919449128 0.702317722500989 +PWY_5101_L_isoleucine_biosyn_II antibiotics Yes -0.321406475080097 0.322324157574382 803 574 0.319030361906549 0.702317722500989 +PWY_5484_glycolysis_II dysbiosisnonIBD Yes 0.220089796638191 0.22127367709723 803 791 0.320285572241064 0.703732817361189 +PWY0_862_dodec_5_enoate_biosyn diagnosis UC -0.454005063389626 0.455093237110103 803 546 0.320802761044266 0.703732817361189 +PWY_6737_starch_deg_V dysbiosisnonIBD Yes 0.277331557564474 0.279660114010408 803 800 0.321678757134368 0.704414290666823 +ARGSYN_PWY_L_arginine_biosyn_I age age -0.146985188555306 0.14508057478336 803 495 0.324021482746925 0.704591217282144 +METSYN_PWY_L_homoserine__L_methionine_biosyn diagnosis CD -0.363557047173971 0.366605844886873 803 375 0.323513525724403 0.704591217282144 +PWY_3841_folate_transformations_II dysbiosisnonIBD Yes 0.231103803307176 0.234142255019383 803 787 0.323947769346722 0.704591217282144 +PWY_5347_SP_of_L_methionine_biosyn dysbiosisCD Yes 0.396291444018503 0.400618811506622 803 373 0.323015563275064 0.704591217282144 +PWY_7400_L_arginine_biosyn_IV age age -0.143904026287996 0.142335405266153 803 495 0.324803418312685 0.705061078776316 +PWY_5103_L_isoleucine_biosyn_III antibiotics Yes -0.191347362689688 0.195087990984666 803 778 0.326991963194208 0.707699091610411 +PWY_5667_CDP_diacylglycerol_biosyn_I antibiotics Yes -0.0773969359980434 0.079012287242581 803 801 0.327615582184156 0.707699091610411 +PWY0_1319_CDP_diacylglycerol_biosyn_II antibiotics Yes -0.07738020291008 0.0790126966839958 803 801 0.327722613049123 0.707699091610411 +PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I dysbiosisnonIBD Yes -0.414725666092734 0.425727829084119 803 764 0.330370722420637 0.709677805151341 +PWY0_1296_purine_rns_deg dysbiosisCD Yes 0.179635883996972 0.184232536934285 803 793 0.32995972005643 0.709677805151341 +PWY0_1297_SP_of_purine_dns_deg dysbiosisCD Yes 0.367577701135418 0.377183749449851 803 610 0.330187486781484 0.709677805151341 +PWY_5347_SP_of_L_methionine_biosyn diagnosis UC -0.383304953212444 0.393046423073454 803 373 0.331784533190165 0.709677805151341 +PWY_6121_5_aminoimidazole_rnt_biosyn_I dysbiosisCD Yes -0.098046130530405 0.100988220878169 803 799 0.332017026424069 0.709677805151341 +UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I diagnosis CD -0.312983012783633 0.321065736928937 803 503 0.332174043531196 0.709677805151341 +PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III dysbiosisCD Yes -0.404225583994397 0.416902464554228 803 512 0.332625873361463 0.709677805151341 +PWY_5177_glutaryl_CoA_deg antibiotics Yes 0.262926004034812 0.272628012296099 803 753 0.335151509573664 0.713844069963736 +PWY0_1296_purine_rns_deg dysbiosisnonIBD Yes 0.293814618419692 0.305385445064678 803 793 0.33632777174012 0.715126968580528 +HISTSYN_PWY_L_histidine_biosyn diagnosis UC 0.265987531052245 0.275888573513624 803 698 0.337550396247076 0.715285363475947 +PWY_7664_oleate_biosyn_IV diagnosis UC -0.445031362158832 0.461693749526902 803 531 0.337356240702463 0.715285363475947 +GLYCOLYSIS_glycolysis_I dysbiosisCD Yes -0.126333981557741 0.132309727633706 803 791 0.340116656868152 0.715853639286685 +GLYCOLYSIS_glycolysis_I age age 0.044852112441672 0.0467237219474298 803 791 0.339614911307102 0.715853639286685 +MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn diagnosis CD -0.366681668744962 0.382638497610988 803 375 0.339993179765044 0.715853639286685 +PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I dysbiosisnonIBD Yes -0.393716830231971 0.411456162824825 803 765 0.338938998261482 0.715853639286685 +PWY_5723_Rubisco_shunt diagnosis CD -0.513225142011282 0.536564770985843 803 212 0.341870200551491 0.718330977887281 +NONOXIPENT_PWY_pentose_phosphate_pwy dysbiosisnonIBD Yes 0.189043058176848 0.200962935644749 803 800 0.347163088082623 0.723890296865171 +PWY_6317_galactose_deg_I antibiotics Yes 0.206321116099443 0.218830105938745 803 765 0.34607225220479 0.723890296865171 +PWY_6353_purine_nt_deg_II diagnosis CD -0.350328212790471 0.371257964247047 803 432 0.348001836133417 0.723890296865171 +PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg diagnosis CD -0.239721762796166 0.254127734978933 803 757 0.347686093902519 0.723890296865171 +PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisCD Yes -0.305108792738564 0.324082225475233 803 469 0.346877532999076 0.723890296865171 +PWY66_400_glycolysis_VI diagnosis CD 0.109913160454258 0.116618443657877 803 789 0.347665384038184 0.723890296865171 +PWY0_1297_SP_of_purine_dns_deg dysbiosisnonIBD Yes 0.575446924606289 0.614169373635604 803 610 0.349107478795937 0.724979864299563 +DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I diagnosis CD -0.115679997898568 0.123906351868758 803 790 0.352323693199957 0.728398804397619 +METSYN_PWY_L_homoserine__L_methionine_biosyn dysbiosisCD Yes 0.378202913466994 0.407410116310244 803 375 0.353676787046998 0.728398804397619 +PWY_5188_tetrapyrrole_biosyn_I dysbiosisnonIBD Yes -0.47221709125025 0.507043329376358 803 731 0.351989191536434 0.728398804397619 +PWY_5723_Rubisco_shunt diagnosis UC -0.537745800946436 0.57637400578665 803 212 0.353603649411766 0.728398804397619 +PWY_7111_pyruvate_fermentation_to_isobutanol dysbiosisCD Yes 0.0946672605507646 0.101958962210295 803 801 0.353534243211042 0.728398804397619 +FUCCAT_PWY_fucose_deg dysbiosisUC Yes 0.802030181822744 0.870094626316831 803 268 0.357015024490399 0.731809615767654 +PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I dysbiosisnonIBD Yes 0.627909537027583 0.680103571796294 803 561 0.356203832489186 0.731809615767654 +THRESYN_PWY_SP_of_L_threonine_biosyn antibiotics Yes -0.0858934688514858 0.0932132360273487 803 796 0.357094900791921 0.731809615767654 +RHAMCAT_PWY_L_rhamnose_deg_I dysbiosisnonIBD Yes 0.508846672328735 0.553056003893437 803 709 0.357831184406979 0.73211437729244 +X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn diagnosis UC 0.179553606318472 0.195092269576381 803 779 0.35928394444394 0.732322456359132 +PWY0_1298_SP_of_pyrimidine_dns_deg dysbiosisnonIBD Yes 0.606104411523998 0.661256276702743 803 455 0.359696102160344 0.732322456359132 +PWY0_1479_tRNA_processing age age -0.208870082288996 0.21186113776904 803 414 0.359298216675175 0.732322456359132 +PWY_6385_peptidoglycan_biosyn_III diagnosis UC 0.0846114177977717 0.0922057215734004 803 797 0.361707939763906 0.73312259694166 +PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine antibiotics Yes 0.310657033050212 0.33984614680766 803 597 0.36096792382445 0.73312259694166 +TCA_TCA_cyc_I dysbiosisUC Yes -0.607237647960337 0.665501777402515 803 412 0.361854251299455 0.73312259694166 +PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I dysbiosisnonIBD Yes -0.246133148972648 0.270860640223247 803 783 0.36382811464079 0.735925050068871 +ARGSYN_PWY_L_arginine_biosyn_I dysbiosisUC Yes -0.495952725668221 0.547895175549764 803 495 0.365659520689264 0.738159353403563 +PWY_6737_starch_deg_V dysbiosisCD Yes 0.163186427308153 0.180463861393837 803 800 0.36618817531067 0.738159353403563 +COA_PWY_1_coenzyme_A_biosyn_II antibiotics Yes 0.0768784532479344 0.085181352888056 803 800 0.367061839100301 0.738159353403563 +PWY_5971_palmitate_biosyn_II diagnosis CD -0.324975791195083 0.359135870916694 803 143 0.368077992973241 0.738159353403563 +PWY_6124_inosine_5_phosphate_biosyn_II dysbiosisnonIBD Yes 0.227774509416025 0.253122795647438 803 792 0.3684872534647 0.738159353403563 +PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I diagnosis CD 0.358872977874818 0.396499327924853 803 561 0.367996844347079 0.738159353403563 +PWY_1042_glycolysis_IV age age 0.0277116845138584 0.0308844999738044 803 803 0.371834324999195 0.742929352069246 +PWY_7560_methylerythritol_phosphate_pwy_II diagnosis UC -0.460217313125674 0.51342193451155 803 226 0.372060927521035 0.742929352069246 +BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn antibiotics Yes -0.171512870423298 0.193099054093214 803 773 0.374709703906923 0.744791962135654 +BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn age age 0.0719108586847795 0.0793302961077823 803 773 0.375807577633069 0.744791962135654 +ILEUSYN_PWY_L_isoleucine_biosyn_I antibiotics Yes -0.117961852138974 0.133296484312454 803 773 0.376461003505097 0.744791962135654 +PWY_5347_SP_of_L_methionine_biosyn diagnosis CD -0.323058121468304 0.363896940356307 803 373 0.376580205574207 0.744791962135654 +PWY_7663_gondoate_biosyn diagnosis UC -0.145773213255502 0.163798122432285 803 792 0.375502786779158 0.744791962135654 +PWY_7663_gondoate_biosyn antibiotics Yes -0.131808467048951 0.14892493920508 803 792 0.376409253632696 0.744791962135654 +COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I dysbiosisCD Yes 0.275940434153089 0.313978127427912 803 578 0.379836971088299 0.745935789930264 +GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg diagnosis UC -0.437712930686162 0.496615070067423 803 300 0.38042707994344 0.745935789930264 +P105_PWY_TCA_cyc_IV dysbiosisCD Yes 0.399727376803163 0.454584454509543 803 101 0.379861015901555 0.745935789930264 +PWY_5188_tetrapyrrole_biosyn_I diagnosis UC 0.317018067228676 0.361222676182248 803 731 0.382155762598196 0.745935789930264 +PWY_5695_urate_biosyn_inosine_5_phosphate_deg dysbiosisnonIBD Yes 0.137081301267819 0.156932641303135 803 800 0.382675475387417 0.745935789930264 +PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II diagnosis UC 0.162511596300685 0.184635140029942 803 769 0.380866003756308 0.745935789930264 +PWY_6282_palmitoleate_biosyn_I diagnosis UC -0.407766051371557 0.464741385953396 803 531 0.382307384433946 0.745935789930264 +PWY_6700_queuosine_biosyn antibiotics Yes -0.163345217869296 0.18666086499023 803 780 0.381802264709536 0.745935789930264 +PYRIDNUCSYN_PWY_NAD_biosyn_I diagnosis CD -0.270083544412814 0.307236957076157 803 707 0.381656676175295 0.745935789930264 +ANAGLYCOLYSIS_PWY_glycolysis_III dysbiosisnonIBD Yes -0.108497338567616 0.124650365018665 803 801 0.384372892912324 0.745935789930264 +PWY_5913_TCA_cyc_VI diagnosis UC -0.502594938124323 0.574057200993756 803 146 0.38391485306318 0.745935789930264 +PWY_6700_queuosine_biosyn age age -0.0677488677654148 0.0776134993057385 803 780 0.384941182122921 0.745935789930264 +THRESYN_PWY_SP_of_L_threonine_biosyn diagnosis CD -0.10166718094886 0.116473922477368 803 796 0.384625059478909 0.745935789930264 +PWY_5989_stearate_biosyn_II dysbiosisCD Yes 0.367624927048447 0.423610392988057 803 575 0.385825406690018 0.746488286856774 +PWY_7383_anaerobic_energy_metabolism diagnosis CD -0.293020245781574 0.337215786966871 803 698 0.386909962351609 0.747426066806364 +PWY_6123_inosine_5_phosphate_biosyn_I dysbiosisCD Yes -0.108406834951033 0.125657930364612 803 794 0.388627183826775 0.748178208776202 +PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn diagnosis CD -0.165818913511363 0.191529419753098 803 761 0.388441830346995 0.748178208776202 +PWY_6703_preQ0_biosyn diagnosis CD -0.190113648147145 0.219848546331906 803 771 0.389100705687784 0.748178208776202 +PWY_7400_L_arginine_biosyn_IV dysbiosisUC Yes -0.461341897020109 0.537269689135543 803 495 0.390799491880239 0.749709883560303 +PWY_7184_pyrimidine_dnt_de_novo_biosyn_I dysbiosisnonIBD Yes -0.316880251852042 0.369476419657702 803 747 0.391409701845375 0.749709883560303 +PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I dysbiosisUC Yes 0.0780014258041415 0.0911951680637518 803 799 0.392648827297626 0.749709883560303 +PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn dysbiosisnonIBD Yes -0.538928429127957 0.630383854765971 803 281 0.392905741544846 0.749709883560303 +PWY_6527_stachyose_deg dysbiosisnonIBD Yes 0.341409882526945 0.398938824221958 803 766 0.392410097972601 0.749709883560303 +X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn antibiotics Yes -0.141401292304004 0.166622411939173 803 779 0.39635262063264 0.755130527994296 +PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I age age -0.022574404892688 0.0265620425070103 803 799 0.397526412370125 0.756210549333093 +UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I diagnosis UC -0.289466379735417 0.342539325314226 803 503 0.40049183745937 0.760690288832889 +PWY_6897_thiamin_salvage_II diagnosis UC 0.277064760357537 0.328685338507257 803 589 0.401208279566769 0.760891196864831 +ARGSYNBSUB_PWY_L_arginine_biosyn_II dysbiosisnonIBD Yes 0.733514181881107 0.875185999804703 803 428 0.402292028865167 0.761787033382976 +P441_PWY_SP_of_N_acetylneuraminate_deg dysbiosisCD Yes 0.390125077768828 0.467317594400169 803 433 0.404185218269796 0.76315461110165 +PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II diagnosis CD -0.0678844768334367 0.0811825199236287 803 798 0.404851683738516 0.76315461110165 +PWY_6545_pyrimidine_dnt_de_novo_biosyn_III diagnosis UC -0.2424173651181 0.289783607229328 803 651 0.404650237034311 0.76315461110165 +GALACTUROCAT_PWY_D_galacturonate_deg_I dysbiosisnonIBD Yes 0.284140451657868 0.341845154646733 803 776 0.406179705602273 0.763403527839024 +PWY_5690_TCA_cyc_II dysbiosisnonIBD Yes -0.601048548682106 0.723146900615002 803 363 0.406209100286736 0.763403527839024 +PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn diagnosis CD -0.301624452507605 0.362477674380339 803 281 0.407130745079967 0.763983295737408 +PWY_5686_UMP_biosyn diagnosis CD -0.0701603871880996 0.0846547129785204 803 802 0.409110469174981 0.765392859747787 +PWY_5973_cis_vaccenate_biosyn diagnosis CD 0.149816433806208 0.180763636162062 803 787 0.409088609085724 0.765392859747787 +BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn dysbiosisCD Yes -0.17533130620534 0.213136378149808 803 773 0.411024303731887 0.76662429304733 +PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I diagnosis UC -0.234959906037839 0.284566302008221 803 765 0.410978971697562 0.76662429304733 +THRESYN_PWY_SP_of_L_threonine_biosyn diagnosis UC -0.105052438987324 0.127438747944523 803 796 0.411614488000533 0.76662429304733 +ANAEROFRUCAT_PWY_homolactic_fermentation age age -0.0741432226395732 0.0873696802805994 803 770 0.413209654880967 0.768446611912962 +ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn diagnosis CD 0.132318507372559 0.161798355433736 803 732 0.415069273560219 0.770754567594684 +GLUCONEO_PWY_gluconeogenesis_I antibiotics Yes -0.45401297673832 0.558481967997923 803 457 0.416620551643833 0.771688290476829 +PWY_7663_gondoate_biosyn age age 0.0621050488000893 0.0741204538299783 803 792 0.416810770056907 0.771688290476829 +PWY_6122_5_aminoimidazole_rnt_biosyn_II diagnosis UC -0.0895852746461563 0.110640126259729 803 799 0.419811456479196 0.774940851515671 +PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn diagnosis UC -0.0895852746461563 0.110640126259729 803 799 0.419811456479196 0.774940851515671 +PWY_7208_SP_of_pyrimidine_nucleobases_salvage diagnosis UC -0.127367685620068 0.157738537285597 803 794 0.421255105297225 0.776084748578333 +PWY_5973_cis_vaccenate_biosyn dysbiosisUC Yes 0.212160436380398 0.263966890386155 803 787 0.421801333015238 0.776084748578333 +GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg dysbiosisCD Yes 0.20392964613613 0.25394275734401 803 755 0.422299726754502 0.776084748578333 +HISDEG_PWY_L_histidine_deg_I antibiotics Yes -0.44054541078446 0.550968215066721 803 582 0.424216416888253 0.776593422442481 +PWY_6123_inosine_5_phosphate_biosyn_I age age 0.0380311896635141 0.0473857888738986 803 794 0.424362782315223 0.776593422442481 +THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III diagnosis UC 0.234542154202362 0.292516687831734 803 682 0.424446324785979 0.776593422442481 +PWY_7219_adenosine_rnt_de_novo_biosyn diagnosis UC 0.0634938940445234 0.0792619141700593 803 803 0.425208360308489 0.776667419076799 +GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg diagnosis CD -0.189169990598566 0.237091499567256 803 757 0.426502240308097 0.776667419076799 +PWY_5177_glutaryl_CoA_deg dysbiosisUC Yes 0.354295454206584 0.445749477604992 803 753 0.426964480478996 0.776667419076799 +PWY_621_sucrose_deg_III dysbiosisUC Yes 0.37617534890111 0.473297853265251 803 741 0.426980081916218 0.776667419076799 +ANAEROFRUCAT_PWY_homolactic_fermentation dysbiosisUC Yes -0.253800633867535 0.322657768831843 803 770 0.431764352625552 0.78405197835467 +HISDEG_PWY_L_histidine_deg_I dysbiosisUC Yes -0.728724564762799 0.933962693653187 803 582 0.435511414888238 0.78405197835467 +ILEUSYN_PWY_L_isoleucine_biosyn_I dysbiosisUC Yes 0.172353293255376 0.220859954584414 803 773 0.435414938648359 0.78405197835467 +PWY_7187_pyrimidine_dnt_de_novo_biosyn_II dysbiosisnonIBD Yes -0.433995979490562 0.553667470441757 803 647 0.433373425678677 0.78405197835467 +PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn diagnosis CD -0.21971719741813 0.279635612438359 803 469 0.433580897288681 0.78405197835467 +PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisnonIBD Yes -0.27500502767726 0.351636959178737 803 742 0.434461063357927 0.78405197835467 +TRNA_CHARGING_PWY_tRNA_charging diagnosis CD -0.250108657568765 0.319302881911771 803 703 0.435147393919986 0.78405197835467 +PWY_7196_SP_of_pyrimidine_rns_salvage diagnosis CD -0.271551862430898 0.347885143448634 803 411 0.436703108329166 0.78405197835467 +PWY0_1297_SP_of_purine_dns_deg diagnosis CD 0.284256675837767 0.363997076856911 803 610 0.436498886483197 0.78405197835467 +PWY_5100_pyruvate_fermentation_to_acetate__lactate_II age age -0.0789341759226309 0.0989784735286132 803 778 0.437706669364021 0.784723036010892 +PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II diagnosis CD -0.0809242683515169 0.104480110087609 803 794 0.440250373036854 0.788149374718276 +ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn antibiotics Yes -0.0896810903682989 0.11723336890832 803 797 0.444521820200474 0.794007344329945 +BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn diagnosis UC -0.168016443898861 0.219176440667961 803 773 0.445121039766945 0.794007344329945 +PANTO_PWY_phosphopantothenate_biosyn_I diagnosis CD -0.0995660651825672 0.130331289159509 803 798 0.446635916195279 0.794007344329945 +PWY_3001_SP_of_L_isoleucine_biosyn_I dysbiosisnonIBD Yes -0.168013356870014 0.221040243110748 803 782 0.447435893153812 0.794007344329945 +PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn diagnosis CD -0.22177603301855 0.290760040609635 803 604 0.447268430061494 0.794007344329945 +FUCCAT_PWY_fucose_deg dysbiosisnonIBD Yes 0.604849194613175 0.799464062407395 803 268 0.449683478412804 0.794007344329945 +NAGLIPASYN_PWY_lipid_IVA_biosyn dysbiosisUC Yes -0.452718932028705 0.599142816275566 803 601 0.450130900137364 0.794007344329945 +PWY_5154_L_arginine_biosyn_III antibiotics Yes 0.28178269648513 0.373194776963222 803 475 0.450479827026328 0.794007344329945 +PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg dysbiosisnonIBD Yes 0.339532703898845 0.447227763833639 803 757 0.448014479943908 0.794007344329945 +PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III diagnosis CD 0.333941014598024 0.440279289829533 803 512 0.449971182462316 0.794007344329945 +PYRIDNUCSYN_PWY_NAD_biosyn_I age age 0.114862509493017 0.141993226725291 803 707 0.45053225717598 0.794007344329945 +PWY_6270_isoprene_biosyn_I dysbiosisnonIBD Yes -0.471354177915771 0.628060456339139 803 219 0.453253955385689 0.797675746342611 +PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I dysbiosisUC Yes -0.188783670222269 0.253806840836739 803 792 0.45722116610948 0.803522669918776 +PWY66_422_D_galactose_deg_V age age -0.0805484378157991 0.106256388776367 803 785 0.460719394047592 0.808530091525774 +PWY4FS_7_phosphatidylglycerol_biosyn_I antibiotics Yes -0.308346136822134 0.420371041792784 803 604 0.463502181147691 0.809991188934113 +PWY4FS_8_phosphatidylglycerol_biosyn_II antibiotics Yes -0.30834690850385 0.420371103290734 803 604 0.463501127991711 0.809991188934113 +THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III diagnosis CD -0.19934706189029 0.270989234908851 803 682 0.463473895227914 0.809991188934113 +PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II dysbiosisUC Yes 0.234350177148487 0.320431397072971 803 769 0.46478514159262 0.810947744557863 +PWY_3841_folate_transformations_II dysbiosisUC Yes -0.159663766266571 0.218913739065628 803 787 0.466018369910024 0.810947744557863 +PWY_7221_guanosine_rnt_de_novo_biosyn diagnosis UC 0.0674924286093114 0.0922440767561742 803 802 0.466215350892219 0.810947744557863 +PWY_5097_L_lysine_biosyn_VI antibiotics Yes -0.0562542196213079 0.0772919729021354 803 802 0.466956599696877 0.810947744557863 +PWY_7221_guanosine_rnt_de_novo_biosyn age age 0.0244930638664768 0.0335468102332625 803 802 0.46730375649482 0.810947744557863 +PWY_6121_5_aminoimidazole_rnt_biosyn_I diagnosis UC -0.0770207468192702 0.105955433341693 803 799 0.468760393194302 0.812037102639861 +DAPLYSINESYN_PWY_L_lysine_biosyn_I dysbiosisUC Yes -0.374740904796736 0.518652470947688 803 595 0.470198816532776 0.812037102639861 +PWY_5989_stearate_biosyn_II diagnosis UC -0.34477477481798 0.474807663817105 803 575 0.470168701937723 0.812037102639861 +PWY_6897_thiamin_salvage_II antibiotics Yes 0.226136034194477 0.313413549006 803 589 0.47081885732791 0.812037102639861 +PWY_5097_L_lysine_biosyn_VI diagnosis UC -0.0635351676848528 0.0881000412565577 803 802 0.472493498727046 0.812037102639861 +PWY0_1297_SP_of_purine_dns_deg dysbiosisUC Yes 0.440082930496004 0.611633699488091 803 610 0.47204204556162 0.812037102639861 +RHAMCAT_PWY_L_rhamnose_deg_I diagnosis UC -0.305674216652378 0.423103686058492 803 709 0.472036435059572 0.812037102639861 +GLUCONEO_PWY_gluconeogenesis_I age age 0.226473887686973 0.315658028197321 803 457 0.47535907152102 0.815193764606655 +P108_PWY_pyruvate_fermentation_to_propanoate_I dysbiosisCD Yes 0.352292527477352 0.493491221100404 803 350 0.475638737455087 0.815193764606655 +PWY_4981_L_proline_biosyn_II age age 0.141880940036808 0.198954232381489 803 678 0.477464095192543 0.817198162925699 +PWY_4041_beta_glutamyl_cyc dysbiosisUC Yes -0.596881596245394 0.841439887797762 803 247 0.478506899151919 0.81785952859162 +PWY_2941_L_lysine_biosyn_II age age -0.13500445529797 0.190214278961248 803 454 0.479685796897061 0.818751373881833 +PWY_3841_folate_transformations_II diagnosis UC 0.116158269306884 0.164776669505899 803 787 0.48229267941301 0.822074799656102 +ARGSYNBSUB_PWY_L_arginine_biosyn_II dysbiosisUC Yes -0.59988596315507 0.858999207605827 803 428 0.485178693590567 0.823613967593796 +GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg antibiotics Yes 0.162741954517075 0.232999258900412 803 757 0.485105446972472 0.823613967593796 +P161_PWY_acetylene_deg diagnosis CD 0.274184047528526 0.39084088223728 803 537 0.484431572911956 0.823613967593796 +PWY_5103_L_isoleucine_biosyn_III diagnosis CD 0.144265831159415 0.206681745695545 803 778 0.486581329548184 0.823750457360105 +PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg antibiotics Yes -0.179115786379087 0.257044413052083 803 757 0.486135405446803 0.823750457360105 +PWY_7237_myo__chiro__scillo_inositol_deg dysbiosisUC Yes 0.549622747404401 0.79111733976881 803 441 0.487437018718803 0.824079410208451 +PWY_4984_urea_cyc age age -0.116975184097127 0.168059951672712 803 665 0.488411318899965 0.824607728115659 +PWY_6969_TCA_cyc_V diagnosis CD -0.233975383415843 0.3375919282512 803 403 0.489794028928838 0.825823220629678 +PENTOSE_P_PWY_pentose_phosphate_pwy antibiotics Yes -0.241271888381484 0.355533274698875 803 613 0.497596316271403 0.828182878927404 +PWY_3001_SP_of_L_isoleucine_biosyn_I age age 0.0358331131689105 0.0526576877894698 803 782 0.49772523336137 0.828182878927404 +PWY_4242_pantothenate__coenzyme_A_biosyn_III antibiotics Yes -0.217360068307901 0.318658116358369 803 725 0.495377684982231 0.828182878927404 +PWY_5104_L_isoleucine_biosyn_IV dysbiosisCD Yes -0.371739837839577 0.546453337621692 803 475 0.496606929061561 0.828182878927404 +PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg dysbiosisCD Yes 0.186892799096126 0.27531286983249 803 757 0.497535210794754 0.828182878927404 +PWY_7242_D_fructuronate_deg diagnosis CD -0.134817587767276 0.198151026224114 803 773 0.497840269917035 0.828182878927404 +PWY_7242_D_fructuronate_deg dysbiosisnonIBD Yes 0.225296615846613 0.331278805870751 803 773 0.496679480172386 0.828182878927404 +PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine diagnosis UC 0.233810469981283 0.340061816555183 803 597 0.493392738324088 0.828182878927404 +PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn diagnosis UC -0.136603635072604 0.199757078252295 803 742 0.49568489141383 0.828182878927404 +TCA_TCA_cyc_I dysbiosisnonIBD Yes 0.431185731980365 0.633198414677848 803 412 0.496216247408681 0.828182878927404 +PWY_5083_NAD_NADH_phosphorylation__dephosphorylation antibiotics Yes 0.341796204235604 0.504783665955917 803 431 0.498607449684134 0.828353176408575 +TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA dysbiosisUC Yes -0.565699597035839 0.837251250188272 803 159 0.499652714668389 0.828984397439165 +ARO_PWY_chorismate_biosyn_I dysbiosisCD Yes -0.123978793208154 0.184569969197361 803 775 0.50202475430003 0.830707627965256 +PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn age age 0.126678499430626 0.187853055058214 803 504 0.501838741717031 0.830707627965256 +HISTSYN_PWY_L_histidine_biosyn dysbiosisCD Yes -0.170500293746244 0.257370512231697 803 698 0.507936058913489 0.83294300026329 +PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I dysbiosisnonIBD Yes 0.06483736172675 0.0982161503110452 803 799 0.509357211683362 0.83294300026329 +PWY_5173_SP_of_acetyl_CoA_biosyn dysbiosisUC Yes -0.515124969273056 0.77375888690974 803 335 0.505913916710475 0.83294300026329 +PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II dysbiosisnonIBD Yes 0.208520950010436 0.31584580017289 803 783 0.509392107705158 0.83294300026329 +PWY_6151_S_adenosyl_L_methionine_cyc_I dysbiosisCD Yes -0.0924977731169687 0.139164509446266 803 791 0.506480265864753 0.83294300026329 +PWY_6737_starch_deg_V diagnosis CD 0.115309567050228 0.173998455880027 803 800 0.508810298728139 0.83294300026329 +RHAMCAT_PWY_L_rhamnose_deg_I diagnosis CD -0.257294862614972 0.387678918555515 803 709 0.508832824113858 0.83294300026329 +TRNA_CHARGING_PWY_tRNA_charging dysbiosisUC Yes -0.335011366230697 0.504907600156428 803 703 0.507206977314101 0.83294300026329 +VALSYN_PWY_L_valine_biosyn diagnosis UC 0.0737706067796814 0.110427376146252 803 802 0.505599305435497 0.83294300026329 +PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I age age -0.0177743269648839 0.0269468581771213 803 799 0.511084332656461 0.834414239050561 +PWY_5188_tetrapyrrole_biosyn_I dysbiosisUC Yes -0.313063934308651 0.480697219033074 803 731 0.515072869294717 0.834414239050561 +PWY_5659_GDP_mannose_biosyn diagnosis CD 0.138968815425609 0.213015284309309 803 788 0.515440067104186 0.834414239050561 +PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I dysbiosisCD Yes 0.273061353877184 0.417868339234083 803 561 0.513728031455979 0.834414239050561 +PWY_7219_adenosine_rnt_de_novo_biosyn diagnosis CD 0.0476854138510645 0.0730782736494033 803 803 0.51564924885147 0.834414239050561 +PWY_7220_adenosine_dnt_de_novo_biosyn_II dysbiosisnonIBD Yes 0.220387641888178 0.33823183668207 803 783 0.514918807402236 0.834414239050561 +PWY_7222_guanosine_dnt_de_novo_biosyn_II dysbiosisnonIBD Yes 0.220387641888178 0.33823183668207 803 783 0.514918807402236 0.834414239050561 +PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn antibiotics Yes -0.303306463959723 0.464790987613854 803 504 0.514240432308052 0.834414239050561 +PWY_4242_pantothenate__coenzyme_A_biosyn_III dysbiosisUC Yes 0.338588696069775 0.524304131979547 803 725 0.518613130212615 0.837737653089671 +OANTIGEN_PWY_O_antigen_building_blocks_biosyn dysbiosisUC Yes 0.347466007604188 0.538938180127816 803 445 0.519311972068319 0.837737653089671 +CITRULBIO_PWY_L_citrulline_biosyn diagnosis UC 0.279716088914324 0.436214255588022 803 688 0.523085496320623 0.837737653089671 +COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I age age -0.0771766792964466 0.121100998179904 803 578 0.525607182502983 0.837737653089671 +COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn dysbiosisUC Yes -0.169787140001192 0.265518833310919 803 773 0.522720530681595 0.837737653089671 +PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I dysbiosisUC Yes -0.466547556336393 0.731093243097638 803 557 0.523575096547067 0.837737653089671 +PWY_5097_L_lysine_biosyn_VI diagnosis CD -0.0518877915579579 0.0816455480202341 803 802 0.526443485047522 0.837737653089671 +PWY_6123_inosine_5_phosphate_biosyn_I dysbiosisnonIBD Yes 0.127768302684255 0.200986028828202 803 794 0.525167411510503 0.837737653089671 +PWY_6163_chorismate_biosyn_from_3_dehydroquinate dysbiosisUC Yes -0.18071410630827 0.284957630890344 803 787 0.526159646111995 0.837737653089671 +PWY_6163_chorismate_biosyn_from_3_dehydroquinate antibiotics Yes 0.11514834236353 0.180811422519066 803 787 0.524419101041088 0.837737653089671 +PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II dysbiosisUC Yes 0.0727204806281228 0.113872656610901 803 798 0.523271950732599 0.837737653089671 +PWY_6609_adenine__adenosine_salvage_III dysbiosisnonIBD Yes -0.149937339223296 0.235990196999181 803 792 0.525425996035577 0.837737653089671 +PWY_6737_starch_deg_V antibiotics Yes -0.103186320524675 0.160849787825962 803 800 0.521386435711639 0.837737653089671 +PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage antibiotics Yes -0.146185275862951 0.231096094852334 803 754 0.527203979997865 0.837877753925178 +PWY_5659_GDP_mannose_biosyn diagnosis UC -0.147005405541461 0.232394268343522 803 788 0.528339496538437 0.83861275501515 +P42_PWY_incomplete_reductive_TCA_cyc dysbiosisnonIBD Yes -0.360892532013228 0.574801704128456 803 636 0.530303225228162 0.839929506690306 +PWY_5154_L_arginine_biosyn_III age age -0.106169173968678 0.16733774045419 803 475 0.532337161734072 0.839929506690306 +PWY_5971_palmitate_biosyn_II diagnosis UC -0.248251081085078 0.397530306859034 803 143 0.53415464541205 0.839929506690306 +PWY_6122_5_aminoimidazole_rnt_biosyn_II antibiotics Yes 0.0624367471253046 0.100651746050674 803 799 0.535235977778574 0.839929506690306 +PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II antibiotics Yes -0.116215496425841 0.185706490483378 803 783 0.531652755393397 0.839929506690306 +PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn antibiotics Yes 0.0624367471253046 0.100651746050674 803 799 0.535235977778574 0.839929506690306 +PWY_6609_adenine__adenosine_salvage_III diagnosis CD -0.0839639505821463 0.134392510039446 803 792 0.533495112810361 0.839929506690306 +PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II dysbiosisUC Yes 0.0978298665677657 0.157503290924366 803 794 0.534701844060636 0.839929506690306 +PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage diagnosis CD -0.152146141735683 0.243782568667987 803 754 0.533868402745375 0.839929506690306 +HISDEG_PWY_L_histidine_deg_I diagnosis UC -0.499854295583145 0.805515093265955 803 582 0.536262725910387 0.840482209414267 +PWY_5104_L_isoleucine_biosyn_IV diagnosis UC 0.347545371098189 0.561431599420493 803 475 0.537302657903888 0.841054160487744 +PWY_5686_UMP_biosyn dysbiosisnonIBD Yes -0.0764528249374153 0.124478059218574 803 802 0.539275529809115 0.842026704438794 +PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I dysbiosisnonIBD Yes 0.163460478470901 0.265970276657448 803 792 0.539041232025105 0.842026704438794 +P161_PWY_acetylene_deg age age 0.115276162848611 0.184545177382031 803 537 0.5421907226296 0.84551894918208 +PWY_7234_inosine_5_phosphate_biosyn_III dysbiosisUC Yes -0.315435470297596 0.518703951262671 803 690 0.543295856764415 0.846183296910576 +PWY_5101_L_isoleucine_biosyn_II dysbiosisUC Yes -0.330532753512635 0.546435116454678 803 574 0.545449162166527 0.847418523764953 +PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn age age 0.0649986328811419 0.105964888024699 803 761 0.545372663137951 0.847418523764953 +DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II dysbiosisUC Yes 0.292280612339545 0.485569277110771 803 614 0.54739938317095 0.848422574344495 +THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III antibiotics Yes -0.158246150913392 0.262932267782635 803 682 0.547457263060172 0.848422574344495 +NAGLIPASYN_PWY_lipid_IVA_biosyn dysbiosisCD Yes 0.220513739412477 0.36781607217985 803 601 0.549049273480464 0.848445054004994 +PWY_7220_adenosine_dnt_de_novo_biosyn_II antibiotics Yes -0.119172157451136 0.199025380938467 803 783 0.549514573500827 0.848445054004994 +PWY_7222_guanosine_dnt_de_novo_biosyn_II antibiotics Yes -0.119172157451136 0.199025380938467 803 783 0.549514573500827 0.848445054004994 +PENTOSE_P_PWY_pentose_phosphate_pwy dysbiosisCD Yes -0.218169950525349 0.366158782591425 803 613 0.551534390612907 0.848554438677825 +PWY_4981_L_proline_biosyn_II diagnosis CD 0.296022268533357 0.495393997700323 803 678 0.551404479580753 0.848554438677825 +PWY_6317_galactose_deg_I dysbiosisUC Yes -0.211649880260304 0.355480398361097 803 765 0.551759832726157 0.848554438677825 +PWY4FS_7_phosphatidylglycerol_biosyn_I diagnosis CD -0.214686255718451 0.360816667832988 803 604 0.552989454502768 0.848554438677825 +PWY4FS_8_phosphatidylglycerol_biosyn_II diagnosis CD -0.214685743786928 0.360816789269676 803 604 0.552990533070942 0.848554438677825 +ARO_PWY_chorismate_biosyn_I age age -0.0417886696778721 0.0708249993142455 803 775 0.556541752753833 0.849543115328404 +COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn antibiotics Yes 0.0973083930837585 0.165144005277431 803 773 0.555883034318901 0.849543115328404 +PWY_7220_adenosine_dnt_de_novo_biosyn_II dysbiosisUC Yes -0.192310265698035 0.327338224344355 803 783 0.557043920724965 0.849543115328404 +PWY_7222_guanosine_dnt_de_novo_biosyn_II dysbiosisUC Yes -0.192310265698035 0.327338224344355 803 783 0.557043920724965 0.849543115328404 +PWY_7663_gondoate_biosyn dysbiosisnonIBD Yes -0.151886380109831 0.258127838642863 803 792 0.55644081797275 0.849543115328404 +HISTSYN_PWY_L_histidine_biosyn antibiotics Yes 0.144682992116357 0.247307956740517 803 698 0.55870213847079 0.85103039674157 +ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn dysbiosisnonIBD Yes 0.116682827671991 0.20200660962395 803 797 0.563696884050892 0.853687742758915 +OANTIGEN_PWY_O_antigen_building_blocks_biosyn dysbiosisnonIBD Yes 0.319430690499164 0.553077943855287 803 445 0.563773928367115 0.853687742758915 +PANTO_PWY_phosphopantothenate_biosyn_I antibiotics Yes -0.0607468078866222 0.105092369245132 803 798 0.563412674112303 0.853687742758915 +PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II dysbiosisCD Yes -0.113075584595279 0.195796887344723 803 769 0.563872401517325 0.853687742758915 +PWY_7221_guanosine_rnt_de_novo_biosyn diagnosis CD 0.0487565448263049 0.0841682619128147 803 802 0.56374806826699 0.853687742758915 +PWY_7196_SP_of_pyrimidine_rns_salvage diagnosis UC -0.216470169408729 0.374622415162138 803 411 0.564696735265922 0.85389821861813 +COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn dysbiosisCD Yes -0.0979704690987414 0.170510401413068 803 773 0.565807237304053 0.854366701619557 +PWY66_422_D_galactose_deg_V antibiotics Yes 0.105989853380255 0.185161202490792 803 785 0.567208253341639 0.854366701619557 +PWYG_321_mycolate_biosyn diagnosis CD 0.242132449010541 0.421944407665412 803 484 0.567277674879864 0.854366701619557 +P105_PWY_TCA_cyc_IV dysbiosisUC Yes 0.4320033052575 0.755960736128793 803 101 0.568062379879828 0.854366701619557 +PWY_7560_methylerythritol_phosphate_pwy_II dysbiosisnonIBD Yes -0.367531583580051 0.64403401371861 803 226 0.568434988477217 0.854366701619557 +PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I dysbiosisUC Yes -0.192104214192965 0.337561844193838 803 762 0.56946199987677 0.854861624298634 +ANAEROFRUCAT_PWY_homolactic_fermentation dysbiosisCD Yes -0.116222188391911 0.204912974052345 803 770 0.570822529226696 0.854861624298634 +GLYOXYLATE_BYPASS_glyoxylate_cyc age age 0.164280126643405 0.28839083493037 803 255 0.570649476897362 0.854861624298634 +PWY_3001_SP_of_L_isoleucine_biosyn_I antibiotics Yes -0.0707538735729037 0.126018247506034 803 782 0.574651726937509 0.856987465723501 +PWY_5101_L_isoleucine_biosyn_II diagnosis UC 0.205353183296105 0.365017571623877 803 574 0.57499319530084 0.856987465723501 +PWY_5989_stearate_biosyn_II antibiotics Yes -0.227315994888472 0.405085194612241 803 575 0.574859241899433 0.856987465723501 +PWY_7196_SP_of_pyrimidine_rns_salvage dysbiosisUC Yes 0.349374476288072 0.621361153879223 803 411 0.574106071451458 0.856987465723501 +NONOXIPENT_PWY_pentose_phosphate_pwy antibiotics Yes -0.0642512552983112 0.114791072364908 803 800 0.575832658941558 0.857213253334745 +PWY_6122_5_aminoimidazole_rnt_biosyn_II dysbiosisCD Yes -0.0588386322751978 0.105753860350136 803 799 0.578173626032338 0.857624211947968 +PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn dysbiosisCD Yes -0.0588386322751978 0.105753860350136 803 799 0.578173626032338 0.857624211947968 +PWY_7187_pyrimidine_dnt_de_novo_biosyn_II diagnosis CD 0.188767014851847 0.337711098678733 803 647 0.577579603423892 0.857624211947968 +PWY_6168_flavin_biosyn_III age age 0.0365696270454645 0.0632833790642562 803 760 0.581493250524086 0.861522699349597 +PWY_2941_L_lysine_biosyn_II dysbiosisnonIBD Yes 0.355227839591377 0.645769987463236 803 454 0.58244399980504 0.861535245747477 +PWY_6353_purine_nt_deg_II dysbiosisCD Yes 0.233651859722447 0.425206455189798 803 432 0.58288460045355 0.861535245747477 +PWY_5676_acetyl_CoA_fermentation_to_butanoate_II age age 0.143328219685695 0.252444750145044 803 459 0.586324195233717 0.865351465818849 +ARO_PWY_chorismate_biosyn_I antibiotics Yes 0.0963154177944008 0.17749966970462 803 775 0.587550032169138 0.865351465818849 +PWY66_409_SP_of_purine_nt_salvage diagnosis CD -0.17088705687489 0.313884836199689 803 290 0.587115068629446 0.865351465818849 +CALVIN_PWY_Calvin_Benson_Bassham_cyc diagnosis CD -0.0658000899230377 0.121806907398519 803 797 0.590197095704089 0.867957720260008 +PWY_5100_pyruvate_fermentation_to_acetate__lactate_II antibiotics Yes -0.114451216372722 0.215324726913734 803 778 0.595230669790468 0.867957720260008 +PWY_5173_SP_of_acetyl_CoA_biosyn age age -0.105054345064086 0.195640453700895 803 335 0.592797351063583 0.867957720260008 +PWY_6151_S_adenosyl_L_methionine_cyc_I dysbiosisUC Yes 0.109360766779388 0.205958076060785 803 791 0.595588965346956 0.867957720260008 +PWY_6737_starch_deg_V diagnosis UC 0.101829006541102 0.189273280379571 803 800 0.591662452097911 0.867957720260008 +PWY_7199_pyrimidine_dns_salvage antibiotics Yes -0.18755893820523 0.352392857673187 803 694 0.594714621961826 0.867957720260008 +PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn diagnosis UC 0.166887158777343 0.31295149651391 803 604 0.595026298120859 0.867957720260008 +SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I antibiotics Yes -0.131660103224542 0.247028784431114 803 767 0.594206609526463 0.867957720260008 +TRNA_CHARGING_PWY_tRNA_charging antibiotics Yes 0.163672141893239 0.30638451919794 803 703 0.593358247069554 0.867957720260008 +PWY_5177_glutaryl_CoA_deg diagnosis CD 0.154732012372335 0.292619824368415 803 753 0.59810333386231 0.86895125203946 +PWY_5723_Rubisco_shunt antibiotics Yes 0.321877738206306 0.610575115283269 803 212 0.598362900682068 0.86895125203946 +PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I antibiotics Yes 0.0304476179910843 0.0576995507295739 803 799 0.597866065620977 0.86895125203946 +PWY_7111_pyruvate_fermentation_to_isobutanol diagnosis UC 0.0576657017380928 0.109428532038838 803 801 0.599343329132323 0.869361802210564 +ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn dysbiosisCD Yes -0.106606469540099 0.204379449377874 803 732 0.602151354281128 0.872419287714285 +PWY_5913_TCA_cyc_VI age age 0.111322990195822 0.200299381403569 803 146 0.603445541249724 0.873278913353259 +CALVIN_PWY_Calvin_Benson_Bassham_cyc dysbiosisnonIBD Yes 0.0945403044056376 0.182866027853295 803 797 0.605312523619025 0.874964506298498 +GLYCOGENSYNTH_PWY_glycogen_biosyn_I diagnosis CD -0.176072607510473 0.342060734651734 803 706 0.607849640995893 0.875375346094694 +ILEUSYN_PWY_L_isoleucine_biosyn_I dysbiosisCD Yes -0.0729855454905937 0.1421248669474 803 773 0.607769623698487 0.875375346094694 +NAGLIPASYN_PWY_lipid_IVA_biosyn diagnosis UC -0.21313976626001 0.413602095015986 803 601 0.607355875432281 0.875375346094694 +PWY_6609_adenine__adenosine_salvage_III antibiotics Yes 0.0700290379816221 0.136621640095117 803 792 0.608406941988768 0.875375346094694 +PWY_5667_CDP_diacylglycerol_biosyn_I dysbiosisnonIBD Yes 0.0701972278652801 0.137565007408636 803 801 0.610000262457458 0.875662935334235 +PWY0_1319_CDP_diacylglycerol_biosyn_II dysbiosisnonIBD Yes 0.0701951668185 0.13756563486912 803 801 0.610012381918231 0.875662935334235 +PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II dysbiosisUC Yes -0.156183590563236 0.306764494162401 803 783 0.610807599242588 0.875795476014113 +ILEUSYN_PWY_L_isoleucine_biosyn_I age age -0.0275778551424589 0.0545151770464202 803 773 0.614094946615522 0.878487145215775 +PWY0_1298_SP_of_pyrimidine_dns_deg dysbiosisUC Yes 0.318111382318804 0.630479938709409 803 455 0.614023726990827 0.878487145215775 +PWY_6385_peptidoglycan_biosyn_III diagnosis CD -0.0428930772586112 0.0849780656014191 803 797 0.61529038411774 0.879187865379248 +PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn antibiotics Yes -0.19047705542177 0.381808126890232 803 281 0.61801739829356 0.880557753772979 +PWY_5973_cis_vaccenate_biosyn antibiotics Yes 0.0785542178521639 0.157370177355312 803 787 0.617804885459328 0.880557753772979 +ANAEROFRUCAT_PWY_homolactic_fermentation diagnosis CD 0.095685859454513 0.192313372482728 803 770 0.619782624445347 0.880557753772979 +PWY_3001_SP_of_L_isoleucine_biosyn_I dysbiosisCD Yes -0.0694388092373997 0.13963655278251 803 782 0.619151947625188 0.880557753772979 +PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I dysbiosisCD Yes 0.0791133608020251 0.159089528687335 803 792 0.619200446467523 0.880557753772979 +FUCCAT_PWY_fucose_deg antibiotics Yes -0.268813894806915 0.542731058836327 803 268 0.620566867902302 0.880667787478665 +ARGSYNBSUB_PWY_L_arginine_biosyn_II antibiotics Yes 0.25845013105188 0.526888387423557 803 428 0.623921914858534 0.883416711265606 +PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn dysbiosisUC Yes 0.154136492843274 0.313856367000612 803 761 0.623494194316957 0.883416711265606 +GALACTUROCAT_PWY_D_galacturonate_deg_I diagnosis UC 0.10002062838946 0.205118357813413 803 776 0.626885201727017 0.885599729423881 +PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn dysbiosisUC Yes 0.332352342352914 0.682287403667663 803 281 0.626327514361166 0.885599729423881 +PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage dysbiosisnonIBD Yes -0.192005575243966 0.396434157234291 803 754 0.628295701281002 0.886587139066963 +PWY_6897_thiamin_salvage_II dysbiosisUC Yes -0.250119422913804 0.51881422128786 803 589 0.629874597569556 0.88780967032994 +PWY_6901_SP_of_glucose__xylose_deg dysbiosisnonIBD Yes -0.27088902349084 0.563579700768873 803 436 0.630918817194334 0.888148332346871 +ANAEROFRUCAT_PWY_homolactic_fermentation dysbiosisnonIBD Yes 0.158260724767384 0.334753512065753 803 770 0.63653006483608 0.888148332346871 +ANAEROFRUCAT_PWY_homolactic_fermentation antibiotics Yes -0.0924709575415646 0.194348891281131 803 770 0.634359000477759 0.888148332346871 +GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg dysbiosisnonIBD Yes -0.203767948972492 0.429377723335741 803 745 0.635262551684249 0.888148332346871 +P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate diagnosis CD -0.227082845081713 0.476032514321855 803 283 0.634321815255349 0.888148332346871 +PWY_5659_GDP_mannose_biosyn age age 0.0400845041792375 0.0842416610034098 803 788 0.635224361626159 0.888148332346871 +PWY_6121_5_aminoimidazole_rnt_biosyn_I antibiotics Yes 0.0455415034371976 0.0952435727626986 803 799 0.632678798498731 0.888148332346871 +PWY_6168_flavin_biosyn_III diagnosis CD 0.0756636209122041 0.159305475616373 803 760 0.635820712774745 0.888148332346871 +PWY_621_sucrose_deg_III diagnosis CD -0.141155984611832 0.297822789642283 803 741 0.636444830252581 0.888148332346871 +PWY_5104_L_isoleucine_biosyn_IV diagnosis CD 0.244832590601865 0.518513778410364 803 475 0.637768397419529 0.888880786560104 +PWY_5104_L_isoleucine_biosyn_IV age age 0.120560943115641 0.251842436729169 803 475 0.640617864514405 0.88995101419868 +PWY_6123_inosine_5_phosphate_biosyn_I antibiotics Yes 0.0539213464925672 0.115478566074816 803 794 0.640679020655069 0.88995101419868 +PWY_6282_palmitoleate_biosyn_I dysbiosisnonIBD Yes 0.341565483531653 0.729262182735749 803 531 0.639678671746601 0.88995101419868 +PWY_2942_L_lysine_biosyn_III dysbiosisUC Yes -0.0524769901212581 0.113608424441743 803 802 0.644279644085528 0.890830992868794 +PWY_5154_L_arginine_biosyn_III dysbiosisCD Yes 0.172169700133286 0.373335687334552 803 475 0.644887283762161 0.890830992868794 +PWY_6168_flavin_biosyn_III diagnosis UC 0.0796996402048473 0.171840765713864 803 760 0.643825587389819 0.890830992868794 +PWY_6608_guanosine_nt_deg_III dysbiosisnonIBD Yes -0.259570785821 0.562482245968241 803 686 0.644616720049195 0.890830992868794 +PWY_7400_L_arginine_biosyn_IV dysbiosisnonIBD Yes 0.248651713722149 0.537785241199386 803 495 0.644004771906352 0.890830992868794 +X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn dysbiosisUC Yes -0.125022938598102 0.276155485266318 803 779 0.650875613086658 0.898107435111823 +PWY_6700_queuosine_biosyn dysbiosisCD Yes -0.0885697149393276 0.196499513830818 803 780 0.652341083773454 0.899133838917836 +PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn dysbiosisnonIBD Yes 0.225781488319905 0.50514148332504 803 604 0.655043684528053 0.901706160926547 +ANAGLYCOLYSIS_PWY_glycolysis_III antibiotics Yes -0.0320454567336267 0.071834601313223 803 801 0.655654720545306 0.901706160926547 +PWY_7664_oleate_biosyn_IV dysbiosisnonIBD Yes 0.321642668913124 0.723048680426995 803 531 0.65658389235552 0.901988456311993 +ARGSYNBSUB_PWY_L_arginine_biosyn_II diagnosis CD 0.212324587874497 0.479993780587995 803 428 0.659123442101324 0.903050339589265 +P161_PWY_acetylene_deg antibiotics Yes 0.166540047423593 0.377450117337775 803 537 0.659181241205257 0.903050339589265 +GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg diagnosis UC 0.112603781038945 0.256608526012112 803 757 0.661622678233394 0.903050339589265 +PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I dysbiosisUC Yes 0.041141550394485 0.0938493587812958 803 799 0.661239138563588 0.903050339589265 +PWY_6969_TCA_cyc_V dysbiosisCD Yes 0.169093931139234 0.38605070860902 803 403 0.661591601121068 0.903050339589265 +PWY66_409_SP_of_purine_nt_salvage dysbiosisnonIBD Yes -0.25055854377306 0.573316465135938 803 290 0.662241010174398 0.903050339589265 +PWY_2942_L_lysine_biosyn_III antibiotics Yes -0.0303727177252129 0.0698076504950035 803 802 0.663619066890711 0.903050339589265 +PWY_5173_SP_of_acetyl_CoA_biosyn diagnosis CD -0.228063907808651 0.525823033216125 803 335 0.665329222907661 0.903050339589265 +PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage diagnosis UC 0.114953182328523 0.264788845614288 803 754 0.665121561530406 0.903050339589265 +PWY4FS_7_phosphatidylglycerol_biosyn_I dysbiosisnonIBD Yes -0.309224303940521 0.713342669418552 803 604 0.664836038824359 0.903050339589265 +PWY4FS_8_phosphatidylglycerol_biosyn_II dysbiosisnonIBD Yes -0.309224478724282 0.713342772545187 803 604 0.664835906333281 0.903050339589265 +PWY_7208_SP_of_pyrimidine_nucleobases_salvage antibiotics Yes -0.0595285579892747 0.138079681989526 803 794 0.666505834038958 0.903610538503663 +PWY_5100_pyruvate_fermentation_to_acetate__lactate_II dysbiosisUC Yes 0.153883823847419 0.357724924635437 803 778 0.667192371928868 0.903610538503663 +GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg diagnosis UC -0.112289650790875 0.261255490508733 803 745 0.668414650934577 0.904275631470536 +ARGSYN_PWY_L_arginine_biosyn_I dysbiosisnonIBD Yes 0.234628522420121 0.548755128727368 803 495 0.669134937572901 0.904275631470536 +PWY_2941_L_lysine_biosyn_II diagnosis CD -0.19999968293381 0.468588748121674 803 454 0.670475839076168 0.905106062284838 +DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I diagnosis UC 0.0569641425977799 0.13435993047291 803 790 0.67239147999433 0.905799253208041 +PWY_6168_flavin_biosyn_III dysbiosisnonIBD Yes -0.12126072857671 0.286684069503259 803 760 0.672443265824589 0.905799253208041 +PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn diagnosis UC -0.164859510635848 0.395952810397796 803 281 0.677991238484195 0.912286266902059 +BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn diagnosis CD 0.0836567057026587 0.202192527178395 803 773 0.679885899394131 0.912578301566996 +PWY_3001_SP_of_L_isoleucine_biosyn_I diagnosis UC -0.0603057876366688 0.145719559975611 803 782 0.679783288976865 0.912578301566996 +P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate diagnosis UC -0.21162599636066 0.514548731411401 803 283 0.68177551265967 0.912578301566996 +ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn diagnosis UC 0.0702074529979595 0.172946808109642 803 732 0.685560502154297 0.912578301566996 +ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn age age -0.0255370447343655 0.0627675724297666 803 732 0.684967507149774 0.912578301566996 +ARO_PWY_chorismate_biosyn_I dysbiosisUC Yes -0.115022665229202 0.283799220437251 803 775 0.685374810012115 0.912578301566996 +DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II diagnosis CD 0.119417413480734 0.295178963987959 803 614 0.686616634715594 0.912578301566996 +PWY_6353_purine_nt_deg_II dysbiosisUC Yes -0.275069534693365 0.682155747546304 803 432 0.686891708030271 0.912578301566996 +PWY_6385_peptidoglycan_biosyn_III dysbiosisnonIBD Yes 0.0567556801182999 0.138891920073838 803 797 0.682930739117003 0.912578301566996 +PWY_7208_SP_of_pyrimidine_nucleobases_salvage dysbiosisnonIBD Yes -0.0968656347257789 0.239583230360024 803 794 0.686103620351504 0.912578301566996 +PWY_7663_gondoate_biosyn diagnosis CD 0.0614479701031413 0.151616413996669 803 792 0.686031392085087 0.912578301566996 +GLUCONEO_PWY_gluconeogenesis_I diagnosis CD -0.304633779391658 0.754909130765817 803 457 0.687650597282937 0.912578301566996 +PWY_7400_L_arginine_biosyn_IV antibiotics Yes 0.130110168856081 0.324093247196538 803 495 0.688210843591321 0.912578301566996 +PWY0_862_dodec_5_enoate_biosyn diagnosis CD 0.168444849552918 0.419722590877362 803 546 0.688949812138604 0.912578301566996 +ANAEROFRUCAT_PWY_homolactic_fermentation diagnosis UC -0.0813729510345524 0.20684456740086 803 770 0.694835632948811 0.912578301566996 +CITRULBIO_PWY_L_citrulline_biosyn antibiotics Yes 0.138914963821929 0.351257548247769 803 688 0.692603763746862 0.912578301566996 +DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II diagnosis UC -0.126874723764572 0.321980509017591 803 614 0.694388524717158 0.912578301566996 +FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation dysbiosisnonIBD Yes -0.278495648181733 0.709258271372669 803 539 0.694703609595717 0.912578301566996 +GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff dysbiosisCD Yes 0.175730165651381 0.448049691722163 803 412 0.695053618127672 0.912578301566996 +P161_PWY_acetylene_deg dysbiosisnonIBD Yes 0.259218448123876 0.652207837915488 803 537 0.69115932207554 0.912578301566996 +PWY_4981_L_proline_biosyn_II diagnosis UC 0.214606559016265 0.543465181911919 803 678 0.693749751650255 0.912578301566996 +PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I antibiotics Yes -0.0618298370184048 0.155023522689027 803 792 0.690126053871281 0.912578301566996 +PWY66_422_D_galactose_deg_V dysbiosisUC Yes -0.117584468169551 0.298681874810039 803 785 0.693930789730725 0.912578301566996 +PANTO_PWY_phosphopantothenate_biosyn_I age age -0.0238501914570868 0.0596158228183141 803 798 0.696568858059346 0.912825878313096 +VALSYN_PWY_L_valine_biosyn antibiotics Yes -0.03810677398313 0.0978106492965489 803 802 0.696944457138387 0.912825878313096 +PYRIDNUCSYN_PWY_NAD_biosyn_I dysbiosisUC Yes -0.182869539097765 0.470674891479746 803 707 0.697736960077054 0.912825878313096 +ARGSYN_PWY_L_arginine_biosyn_I antibiotics Yes 0.127571046721802 0.330515910328693 803 495 0.6996378120297 0.912825878313096 +PWY_5101_L_isoleucine_biosyn_II dysbiosisCD Yes -0.150705329469678 0.389753871774593 803 574 0.699121546317071 0.912825878313096 +PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III dysbiosisnonIBD Yes -0.257911241236011 0.665735264368245 803 512 0.698567901260137 0.912825878313096 +PWY_5097_L_lysine_biosyn_VI dysbiosisUC Yes -0.0488144159159483 0.127282699928519 803 802 0.701447831944025 0.912839741429622 +PWY_5667_CDP_diacylglycerol_biosyn_I diagnosis UC 0.0396088954682562 0.103159758118512 803 801 0.701769175407904 0.912839741429622 +PWY0_1319_CDP_diacylglycerol_biosyn_II diagnosis UC 0.0395983317314225 0.103160279258322 803 801 0.701846285946692 0.912839741429622 +PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I dysbiosisnonIBD Yes -0.134990130037366 0.354783273481417 803 762 0.703692862592652 0.913334694573379 +THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III dysbiosisnonIBD Yes -0.172894153092882 0.453580468603494 803 682 0.703188483848309 0.913334694573379 +ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn dysbiosisnonIBD Yes 0.131366003473843 0.352079124902083 803 732 0.70917932203572 0.914434534579253 +GLYCOLYSIS_glycolysis_I diagnosis UC -0.0488685193558979 0.130898211717569 803 791 0.709677524027398 0.914434534579253 +PWY_5973_cis_vaccenate_biosyn diagnosis UC -0.0743402827024323 0.19668556219699 803 787 0.706230819618359 0.914434534579253 +PWY_6282_palmitoleate_biosyn_I diagnosis CD 0.160233216641341 0.428001401245197 803 531 0.708836950544682 0.914434534579253 +PWY_6317_galactose_deg_I age age -0.0474624688438757 0.124970707131736 803 765 0.707550060139799 0.914434534579253 +PWY4FS_7_phosphatidylglycerol_biosyn_I dysbiosisUC Yes -0.266890392859829 0.712578524140712 803 604 0.708107506140999 0.914434534579253 +PWY4FS_8_phosphatidylglycerol_biosyn_II dysbiosisUC Yes -0.266890616805188 0.712578578634612 803 604 0.708107293757493 0.914434534579253 +P105_PWY_TCA_cyc_IV age age 0.0710741233755839 0.192509786053188 803 101 0.713131781125539 0.916988853748629 +PWY_1042_glycolysis_IV diagnosis UC 0.03158410469444 0.0854924486291786 803 803 0.712555954393701 0.916988853748629 +PWY_7388_octanoyl_acyl_carrier_protein_biosyn dysbiosisnonIBD Yes -0.264088889493427 0.720147809111753 803 535 0.713952021751574 0.917097133095321 +PWY_5104_L_isoleucine_biosyn_IV dysbiosisUC Yes 0.304722414537951 0.83326703302692 803 475 0.71469763713617 0.917109429322006 +PWY_5971_palmitate_biosyn_II dysbiosisUC Yes 0.254479223421517 0.701118200629164 803 143 0.716767186873049 0.918818842431913 +METSYN_PWY_L_homoserine__L_methionine_biosyn age age 0.0511816184178654 0.141955395028081 803 375 0.719287153658935 0.920660210915999 +PWY66_409_SP_of_purine_nt_salvage diagnosis UC 0.122432250406902 0.340318978713512 803 290 0.719681416879762 0.920660210915999 +PWY_5971_palmitate_biosyn_II dysbiosisnonIBD Yes 0.263308879342124 0.738458797082863 803 143 0.721554043241403 0.922109064491065 +PWY_3001_SP_of_L_isoleucine_biosyn_I diagnosis CD -0.047518095719333 0.134125520168574 803 782 0.723753294149358 0.923971930850512 +COA_PWY_1_coenzyme_A_biosyn_II diagnosis CD -0.0334857909490798 0.0966102840885132 803 800 0.729536246291384 0.92825104374828 +PANTO_PWY_phosphopantothenate_biosyn_I diagnosis UC -0.0490607132498302 0.142052611234391 803 798 0.730531676949068 0.92825104374828 +PWY_7456_mannan_deg age age 0.0498770995795295 0.143248926015717 803 210 0.728531392494731 0.92825104374828 +PWY_7663_gondoate_biosyn dysbiosisUC Yes -0.0860352393027364 0.24999510147822 803 792 0.73083007537485 0.92825104374828 +PWY0_1297_SP_of_purine_dns_deg age age 0.0612392182116627 0.173330913669607 803 610 0.72965281175478 0.92825104374828 +FASYN_ELONG_PWY_fatty_acid_elongation__saturated dysbiosisnonIBD Yes 0.243532154989985 0.714165952554656 803 532 0.733215236670225 0.928401566448133 +MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn age age 0.0503957983555268 0.148237664329178 803 375 0.734674112775168 0.928401566448133 +PWY_4981_L_proline_biosyn_II dysbiosisCD Yes -0.147320432493752 0.433883020896791 803 678 0.734307253604342 0.928401566448133 +PWY_6700_queuosine_biosyn dysbiosisnonIBD Yes 0.10993006456868 0.324221812400296 803 780 0.734663874750423 0.928401566448133 +PWY_6936_seleno_amino_acid_biosyn age age -0.0528729066774791 0.154690350619924 803 472 0.733241326867752 0.928401566448133 +PWY_4242_pantothenate__coenzyme_A_biosyn_III age age -0.0520127515182591 0.150525230167832 803 725 0.737541684532446 0.931080991821102 +PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I dysbiosisnonIBD Yes -0.238087174346877 0.713111491300282 803 557 0.738610600893107 0.931486648494748 +FUCCAT_PWY_fucose_deg age age 0.0560505935807214 0.16811074687672 803 268 0.73953144913814 0.931704939965746 +PWY_5101_L_isoleucine_biosyn_II diagnosis CD 0.111653687295102 0.336192913087888 803 574 0.74046460287833 0.93193827796606 +CITRULBIO_PWY_L_citrulline_biosyn diagnosis CD -0.127309100390157 0.396737888172622 803 688 0.749021942741584 0.937070022779263 +HISTSYN_PWY_L_histidine_biosyn age age -0.0352721635562499 0.106972059895261 803 698 0.752368910537756 0.937070022779263 +P441_PWY_SP_of_N_acetylneuraminate_deg diagnosis UC -0.149876197424828 0.473334019087296 803 433 0.752215808174586 0.937070022779263 +PWY_4041_beta_glutamyl_cyc diagnosis UC -0.181560299557174 0.565937157051848 803 247 0.749116292463855 0.937070022779263 +PWY_5154_L_arginine_biosyn_III dysbiosisnonIBD Yes 0.19864441990815 0.621156377798969 803 475 0.749242429432393 0.937070022779263 +PWY_5347_SP_of_L_methionine_biosyn antibiotics Yes -0.130558378243682 0.405639866197513 803 373 0.747651726788536 0.937070022779263 +PWY_5695_urate_biosyn_inosine_5_phosphate_deg age age 0.0118218796427471 0.0372325553824169 803 800 0.751585483490984 0.937070022779263 +PWY_6385_peptidoglycan_biosyn_III age age -0.0136635231251779 0.0371403116753906 803 797 0.747588969229386 0.937070022779263 +PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I diagnosis CD -0.0211937154866531 0.067102859490642 803 799 0.752726886925645 0.937070022779263 +PWY_7219_adenosine_rnt_de_novo_biosyn age age 0.0128944533662519 0.0396407998173308 803 803 0.750300957730362 0.937070022779263 +PWY_7664_oleate_biosyn_IV diagnosis CD 0.134282716928522 0.42533332632401 803 531 0.752814681221543 0.937070022779263 +PWY_5347_SP_of_L_methionine_biosyn age age 0.0443238352498698 0.141333665000814 803 373 0.754536646547041 0.938030324429936 +PWY_1042_glycolysis_IV antibiotics Yes -0.0224747553282813 0.0724182542907425 803 803 0.756382591658102 0.938030324429936 +PWY_5913_TCA_cyc_VI diagnosis CD -0.162723863757409 0.524448218548437 803 146 0.757281131749866 0.938030324429936 +PWY0_1261_anhydromuropeptides_recycling antibiotics Yes 0.158440551893989 0.508959926151127 803 273 0.755672024981371 0.938030324429936 +SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I dysbiosisCD Yes 0.0831357443622123 0.268966227500255 803 767 0.757350326144876 0.938030324429936 +PWY_7456_mannan_deg dysbiosisCD Yes 0.127649455659716 0.416009035894959 803 210 0.759099418801069 0.939263034584044 +DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II dysbiosisCD Yes 0.0938581260026968 0.308107659201668 803 614 0.760754605733129 0.940377220975673 +COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I diagnosis UC 0.0991556464865315 0.326395888187728 803 578 0.761996149682992 0.940978396932614 +P441_PWY_SP_of_N_acetylneuraminate_deg antibiotics Yes 0.137514144812699 0.457129563480297 803 433 0.763636972783504 0.942070958503214 +PWY0_1261_anhydromuropeptides_recycling diagnosis CD -0.132725546895351 0.443088559605794 803 273 0.76516392670968 0.942475084513843 +ARGSYNBSUB_PWY_L_arginine_biosyn_II age age -0.0675209950603636 0.226043723238274 803 428 0.770269552690132 0.942475084513843 +DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I dysbiosisnonIBD Yes -0.0625380415016001 0.213780453931222 803 790 0.769963822183368 0.942475084513843 +GLYCOLYSIS_glycolysis_I diagnosis CD -0.0357809726200614 0.121946513224749 803 791 0.769736377099344 0.942475084513843 +METSYN_PWY_L_homoserine__L_methionine_biosyn antibiotics Yes -0.120257020424552 0.413734306039148 803 375 0.771391766679024 0.942475084513843 +P42_PWY_incomplete_reductive_TCA_cyc diagnosis CD 0.0989599711434069 0.334233400829309 803 636 0.767697556190173 0.942475084513843 +PWY_5690_TCA_cyc_II dysbiosisUC Yes 0.224698916575252 0.764293934374487 803 363 0.768846630338954 0.942475084513843 +PWY_6168_flavin_biosyn_III dysbiosisCD Yes -0.0533533074139066 0.1795463603467 803 760 0.766456790424334 0.942475084513843 +PWY_7111_pyruvate_fermentation_to_isobutanol antibiotics Yes 0.0279920480700917 0.0958381237295739 803 801 0.770308494381175 0.942475084513843 +RIBOSYN2_PWY_flavin_biosyn_I dysbiosisnonIBD Yes -0.179943326085811 0.619521585391013 803 478 0.771556961245975 0.942475084513843 +P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate dysbiosisnonIBD Yes 0.252740975814099 0.873664140668683 803 283 0.772458337238453 0.942475084513843 +PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I age age 0.0378068355378872 0.126828294435982 803 765 0.773041361455175 0.942475084513843 +BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn dysbiosisUC Yes -0.0914932910758311 0.319078811465629 803 773 0.774388122091758 0.943194135020851 +COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I diagnosis CD -0.0856756104198244 0.300985978995244 803 578 0.776524272089012 0.944006138499694 +PWY_6527_stachyose_deg age age -0.0390855826039406 0.136527869014055 803 766 0.776570057754564 0.944006138499694 +PWY_5103_L_isoleucine_biosyn_III diagnosis UC -0.0627372445370985 0.224216847499278 803 778 0.780169177134013 0.944046020612253 +PWY_7199_pyrimidine_dns_salvage age age 0.0571196332742552 0.198791899733028 803 694 0.777905972392828 0.944046020612253 +PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn diagnosis UC -0.0850114154530979 0.301765465159578 803 469 0.778697245320533 0.944046020612253 +PWY0_1298_SP_of_pyrimidine_dns_deg diagnosis UC -0.112505309125044 0.40237319758348 803 455 0.780391172737256 0.944046020612253 +RHAMCAT_PWY_L_rhamnose_deg_I dysbiosisUC Yes 0.147104199426848 0.524949975134721 803 709 0.779383208804003 0.944046020612253 +PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II dysbiosisnonIBD Yes 0.0918164930805284 0.330633435793268 803 769 0.781341164755783 0.944278459055001 +COA_PWY_coenzyme_A_biosyn_I dysbiosisUC Yes -0.098319714458148 0.359558555565237 803 774 0.784584998452694 0.944572918203305 +ILEUSYN_PWY_L_isoleucine_biosyn_I dysbiosisnonIBD Yes 0.0632491187414025 0.231336128739943 803 773 0.784617151156036 0.944572918203305 +NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I diagnosis CD -0.0273427834841363 0.0992680727580057 803 799 0.783487747083792 0.944572918203305 +PWY_7111_pyruvate_fermentation_to_isobutanol age age -0.0108776911569203 0.0394109019579424 803 801 0.783144565157614 0.944572918203305 +VALSYN_PWY_L_valine_biosyn diagnosis CD 0.0277731983410674 0.101755668189576 803 802 0.785402645909076 0.9446058849447 +THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III dysbiosisUC Yes 0.116486769929949 0.429793524913899 803 682 0.78644198458323 0.944943792469339 +PWY_7237_myo__chiro__scillo_inositol_deg antibiotics Yes 0.13305599146356 0.493783785196123 803 441 0.787653791526043 0.945488077303901 +COA_PWY_coenzyme_A_biosyn_I dysbiosisnonIBD Yes 0.0973009667236138 0.377222505738827 803 774 0.796525836800066 0.949390688011804 +DAPLYSINESYN_PWY_L_lysine_biosyn_I diagnosis UC -0.0805741011894519 0.31215361161718 803 595 0.796802324966692 0.949390688011804 +GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg dysbiosisUC Yes 0.217130799671709 0.828859352897586 803 300 0.793453153318666 0.949390688011804 +MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn antibiotics Yes -0.112811504392164 0.432523931290568 803 375 0.79430347860522 0.949390688011804 +P161_PWY_acetylene_deg diagnosis UC -0.109332231384886 0.42121265283299 803 537 0.795709217121729 0.949390688011804 +PWY_5083_NAD_NADH_phosphorylation__dephosphorylation diagnosis UC -0.124416256580876 0.482247197790686 803 431 0.797000529422429 0.949390688011804 +PWY_6703_preQ0_biosyn antibiotics Yes -0.0572441880986086 0.220876840664282 803 771 0.795577852481883 0.949390688011804 +PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II diagnosis UC -0.0296847092579987 0.113168180824175 803 794 0.793584139219734 0.949390688011804 +P441_PWY_SP_of_N_acetylneuraminate_deg dysbiosisUC Yes -0.192338096273704 0.751657888674565 803 433 0.798109426207033 0.949803576937883 +CALVIN_PWY_Calvin_Benson_Bassham_cyc antibiotics Yes -0.0263776098664457 0.104255846532156 803 797 0.800329838571275 0.95153719356852 +HISDEG_PWY_L_histidine_deg_I dysbiosisnonIBD Yes -0.233672107054306 0.941907961795535 803 582 0.804140505723794 0.954246733458902 +PWY_5030_L_histidine_deg_III dysbiosisnonIBD Yes -0.172753593489062 0.695303725524179 803 542 0.80385195681493 0.954246733458902 +PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II antibiotics Yes -0.0168519326929191 0.0686112457102543 803 798 0.8060465363195 0.954908457807384 +COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I dysbiosisnonIBD Yes -0.120569927200954 0.501466055491099 803 578 0.810062792859073 0.954908457807384 +PWY_2941_L_lysine_biosyn_II dysbiosisUC Yes -0.145754337520696 0.600089658065519 803 454 0.808171524851605 0.954908457807384 +PWY_6122_5_aminoimidazole_rnt_biosyn_II age age -0.0132685232154712 0.0539905431328548 803 799 0.80782442656614 0.954908457807384 +PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn age age -0.0132685232154712 0.0539905431328548 803 799 0.80782442656614 0.954908457807384 +PWY66_400_glycolysis_VI dysbiosisnonIBD Yes 0.0558864428325956 0.232271768187951 803 789 0.809950372642933 0.954908457807384 +TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA age age 0.0505601186445094 0.197111552484076 803 159 0.808874152111382 0.954908457807384 +ANAGLYCOLYSIS_PWY_glycolysis_III age age 0.00637022168552362 0.026882616617272 803 801 0.813147596586495 0.956734565955404 +PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I age age 0.0167586843956497 0.0687321393888056 803 783 0.813132488167213 0.956734565955404 +TCA_TCA_cyc_I age age -0.0349298440879098 0.144834572861978 803 412 0.816029257586827 0.959219297125648 +PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III antibiotics Yes -0.090227367675477 0.392936159532907 803 512 0.818447729006465 0.961155391462823 +ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn age age 0.0114092506236743 0.049872208538735 803 797 0.819571252606123 0.961568531777052 +PWY_5690_TCA_cyc_II age age 0.0346210865323525 0.153729466706081 803 363 0.822293175621493 0.963816414842601 +COA_PWY_1_coenzyme_A_biosyn_II dysbiosisnonIBD Yes -0.0327507056549332 0.148249012097724 803 800 0.825216828567442 0.963816414842601 +PWY_5484_glycolysis_II diagnosis CD -0.027624175244927 0.123693258945844 803 791 0.823825785636731 0.963816414842601 +PWY_6121_5_aminoimidazole_rnt_biosyn_I age age -0.0112634881943941 0.0506244329584931 803 799 0.826017867143902 0.963816414842601 +PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I diagnosis UC 0.0945368366052982 0.428924522782664 803 561 0.826128355579372 0.963816414842601 +PWY_7456_mannan_deg dysbiosisnonIBD Yes 0.129021827289621 0.58033273632204 803 210 0.824147606855479 0.963816414842601 +GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg dysbiosisnonIBD Yes -0.0883250632055019 0.404012120973483 803 757 0.827010918321554 0.963943502552532 +ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn diagnosis UC -0.0301126077424381 0.138282183512921 803 797 0.828067162474254 0.964272602283103 +GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff dysbiosisnonIBD Yes 0.154327850891066 0.720959554377457 803 412 0.830567405075605 0.965637730199036 +PWY_5676_acetyl_CoA_fermentation_to_butanoate_II diagnosis UC 0.132773626081784 0.619539992678004 803 459 0.830789443638336 0.965637730199036 +PWY_2941_L_lysine_biosyn_II dysbiosisCD Yes -0.0865059071109091 0.412984231963721 803 454 0.834152020169238 0.965941837482222 +PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I antibiotics Yes 0.0848117183102962 0.404917408907444 803 561 0.834151240601847 0.965941837482222 +PWY_621_sucrose_deg_III diagnosis UC -0.0678025528875444 0.320791521597447 803 741 0.833017418443811 0.965941837482222 +THRESYN_PWY_SP_of_L_threonine_biosyn dysbiosisnonIBD Yes 0.0346769348602921 0.163582523714068 803 796 0.832175796128333 0.965941837482222 +PWY0_1586_peptidoglycan_maturation dysbiosisUC Yes 0.0942933188584713 0.45413306508715 803 773 0.835570777839101 0.966686340935487 +PWY_5695_urate_biosyn_inosine_5_phosphate_deg diagnosis CD 0.0195933022038674 0.0948397722269809 803 800 0.836722940907405 0.967121321308559 +GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff diagnosis CD 0.0860788870625864 0.424483628470767 803 412 0.839677737787091 0.967725180212891 +PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I age age -0.0216662708500813 0.104239382778557 803 762 0.839287304402499 0.967725180212891 +PWY_5989_stearate_biosyn_II dysbiosisnonIBD Yes -0.144992886715091 0.712345667703487 803 575 0.838767865981228 0.967725180212891 +PWY_7400_L_arginine_biosyn_IV diagnosis CD 0.0565194807899164 0.28015424259659 803 495 0.840464727523344 0.967725180212891 +NONOXIPENT_PWY_pentose_phosphate_pwy dysbiosisUC Yes -0.0363597775564673 0.184061375467335 803 800 0.843458704423114 0.967725180212891 +P161_PWY_acetylene_deg dysbiosisUC Yes -0.128834096127793 0.648357182747972 803 537 0.842544711619418 0.967725180212891 +PWY_5103_L_isoleucine_biosyn_III dysbiosisUC Yes 0.0642987130633935 0.321702276052543 803 778 0.841635621727393 0.967725180212891 +PWY_7388_octanoyl_acyl_carrier_protein_biosyn diagnosis CD 0.0846544345635402 0.426051433967784 803 535 0.84302151328636 0.967725180212891 +PWY_6270_isoprene_biosyn_I age age -0.0355995350412682 0.181153776854143 803 219 0.844607463123897 0.968106047736456 +ARGSYN_PWY_L_arginine_biosyn_I diagnosis CD 0.0559055296236897 0.285971513144147 803 495 0.845344606691223 0.968106047736456 +FASYN_ELONG_PWY_fatty_acid_elongation__saturated diagnosis CD 0.0774202201788093 0.415205052481696 803 532 0.852424627200729 0.969264316409762 +GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg dysbiosisnonIBD Yes 0.150881772874686 0.796927247876802 803 300 0.849922834433086 0.969264316409762 +GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff age age 0.0316356234098924 0.165841928519082 803 412 0.849136962077509 0.969264316409762 +HISTSYN_PWY_L_histidine_biosyn diagnosis CD 0.0479721588461487 0.254293384354587 803 698 0.850784609691758 0.969264316409762 +PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I diagnosis UC -0.0137489004774228 0.074198365983773 803 799 0.853357106823041 0.969264316409762 +PWY_6121_5_aminoimidazole_rnt_biosyn_I diagnosis CD 0.0184885851717457 0.0980561257334859 803 799 0.850758580776006 0.969264316409762 +PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III diagnosis UC -0.0888915106208284 0.479146756105171 803 512 0.853218713197075 0.969264316409762 +RIBOSYN2_PWY_flavin_biosyn_I age age -0.0442643088834289 0.234682763028092 803 478 0.851882855703306 0.969264316409762 +VALSYN_PWY_L_valine_biosyn age age -0.00747699184169394 0.0397410259433155 803 802 0.851169719256828 0.969264316409762 +NONOXIPENT_PWY_pentose_phosphate_pwy diagnosis UC 0.0294751629813949 0.160142279134041 803 800 0.854340804195804 0.969497852484492 +GALACTUROCAT_PWY_D_galacturonate_deg_I antibiotics Yes -0.035786919631631 0.196748500881838 803 776 0.855719445127178 0.970178733965845 +PWY_7383_anaerobic_energy_metabolism antibiotics Yes 0.0687162508655022 0.386816083146398 803 698 0.859055948730055 0.97257339148217 +PWY66_399_gluconeogenesis_III dysbiosisnonIBD Yes -0.126776420572412 0.716643551793518 803 670 0.859636700814362 0.97257339148217 +PWY_5723_Rubisco_shunt dysbiosisUC Yes 0.161271361874985 0.918344505490363 803 212 0.860686884550354 0.97257339148217 +GLYOXYLATE_BYPASS_glyoxylate_cyc dysbiosisUC Yes 0.188961591005552 1.13558922533419 803 255 0.867917063379706 0.97257339148217 +HISDEG_PWY_L_histidine_deg_I dysbiosisCD Yes -0.104892304924148 0.610759358946169 803 582 0.86369125030829 0.97257339148217 +PWY_6122_5_aminoimidazole_rnt_biosyn_II diagnosis CD 0.0167662775178569 0.102483962663938 803 799 0.870320490772568 0.97257339148217 +PWY_6151_S_adenosyl_L_methionine_cyc_I diagnosis UC -0.0301654978880657 0.174744030057817 803 791 0.863285825815673 0.97257339148217 +PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn diagnosis CD 0.0167662775178569 0.102483962663938 803 799 0.870320490772568 0.97257339148217 +PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II age age -0.00534820506676208 0.0321907696137957 803 798 0.868392888993381 0.97257339148217 +PWY_6969_TCA_cyc_V dysbiosisUC Yes -0.107428164135947 0.6438921375505 803 403 0.86754372440698 0.97257339148217 +PWY_7208_SP_of_pyrimidine_nucleobases_salvage diagnosis CD -0.0241453828561681 0.144955782731686 803 794 0.868010003247654 0.97257339148217 +PWY_7219_adenosine_rnt_de_novo_biosyn dysbiosisnonIBD Yes 0.0179649076172534 0.10666856037224 803 803 0.866300098539226 0.97257339148217 +PWY0_1261_anhydromuropeptides_recycling diagnosis UC -0.0797461913784344 0.477811222206161 803 273 0.867830881406903 0.97257339148217 +PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn diagnosis CD -0.0303766528034871 0.184634539586767 803 742 0.869628855678225 0.97257339148217 +SALVADEHYPOX_PWY_adenosine_nt_deg_II dysbiosisnonIBD Yes -0.107489940663388 0.650613529323702 803 638 0.868826788848617 0.97257339148217 +TRNA_CHARGING_PWY_tRNA_charging diagnosis UC -0.0570744164723366 0.347921598271006 803 703 0.870021072405069 0.97257339148217 +PWY0_1479_tRNA_processing diagnosis CD 0.0765872335155579 0.472966380156001 803 414 0.871721540267562 0.973131903005061 +X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn dysbiosisnonIBD Yes 0.0462378509463864 0.289408827010373 803 779 0.873108283478433 0.973131903005061 +PWY_621_sucrose_deg_III age age -0.0265791157254554 0.165358371695718 803 741 0.873163296596836 0.973131903005061 +FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation diagnosis CD 0.0664725376698973 0.419739013523612 803 539 0.874509179541295 0.973760891607197 +P42_PWY_incomplete_reductive_TCA_cyc antibiotics Yes 0.0527162328612199 0.342514321977866 803 636 0.877723430620086 0.976132281104143 +PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I antibiotics Yes -0.0242087849285018 0.15792017255768 803 783 0.878205687895461 0.976132281104143 +COA_PWY_coenzyme_A_biosyn_I age age -0.0154464842333198 0.0981234423164213 803 774 0.879302559819499 0.976480382829854 +PWY_6121_5_aminoimidazole_rnt_biosyn_I dysbiosisnonIBD Yes 0.0245083745919218 0.164514325400582 803 799 0.88161635294737 0.976483770566943 +PWY_6124_inosine_5_phosphate_biosyn_II dysbiosisCD Yes 0.0236427971606393 0.158753168283297 803 792 0.881656694934038 0.976483770566943 +PWY_6527_stachyose_deg antibiotics Yes -0.034616726571255 0.23090956888092 803 766 0.880873054317342 0.976483770566943 +PWY_5101_L_isoleucine_biosyn_II age age -0.0194071158853678 0.134905237132262 803 574 0.885918889257015 0.979463119799681 +PWY_7184_pyrimidine_dnt_de_novo_biosyn_I diagnosis CD 0.0279758423458523 0.194346431331778 803 747 0.8857955948717 0.979463119799681 +PWY66_399_gluconeogenesis_III antibiotics Yes 0.0621880238833907 0.450199213456222 803 670 0.890173907135478 0.983294936428019 +COA_PWY_1_coenzyme_A_biosyn_II dysbiosisUC Yes -0.0186912869563903 0.138103541469748 803 800 0.892377504185275 0.983652511316195 +PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine diagnosis CD 0.0428878563962363 0.316009418522706 803 597 0.89231150853212 0.983652511316195 +PWY_7197_pyrimidine_dnt_phosphorylation age age -0.0136945932710712 0.102639114242384 803 751 0.894184690329 0.983652511316195 +RHAMCAT_PWY_L_rhamnose_deg_I age age 0.0219539217983527 0.155430052862688 803 709 0.894709135735943 0.983652511316195 +UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I dysbiosisUC Yes 0.0791333659764683 0.596422820760912 803 503 0.894483639482164 0.983652511316195 +PWY_5083_NAD_NADH_phosphorylation__dephosphorylation diagnosis CD -0.0588502988970291 0.446451145370933 803 431 0.895394888733824 0.983652511316195 +GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg diagnosis UC -0.0319125937595387 0.245651175306434 803 755 0.896911701329041 0.983652511316195 +PWY0_1586_peptidoglycan_maturation diagnosis UC 0.0357808421256158 0.27726893120892 803 773 0.897569757835985 0.983652511316195 +PWY0_1586_peptidoglycan_maturation diagnosis CD 0.0329817269261544 0.255787819811083 803 773 0.897631424860571 0.983652511316195 +PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II dysbiosisnonIBD Yes -0.0152651869670583 0.119506229852395 803 798 0.898392101025546 0.983652511316195 +DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II dysbiosisnonIBD Yes 0.0564872802217534 0.510504453667636 803 614 0.911924485503274 0.984789800002539 +GLYCOGENSYNTH_PWY_glycogen_biosyn_I diagnosis UC 0.0408937658675823 0.368925045918869 803 706 0.911972151384125 0.984789800002539 +GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff antibiotics Yes -0.05000102947547 0.434403643499732 803 412 0.908396055881251 0.984789800002539 +HISTSYN_PWY_L_histidine_biosyn dysbiosisUC Yes -0.047101099061507 0.412388110230262 803 698 0.909097186727545 0.984789800002539 +ILEUSYN_PWY_L_isoleucine_biosyn_I diagnosis CD -0.0154665527306435 0.139508799994874 803 773 0.911917743252729 0.984789800002539 +P108_PWY_pyruvate_fermentation_to_propanoate_I antibiotics Yes -0.0519405598315996 0.461856789177833 803 350 0.910503683509027 0.984789800002539 +P42_PWY_incomplete_reductive_TCA_cyc age age 0.0152475176676027 0.131644274644038 803 636 0.908022131236069 0.984789800002539 +P441_PWY_SP_of_N_acetylneuraminate_deg dysbiosisnonIBD Yes 0.089135872431627 0.769548190340506 803 433 0.907822694404047 0.984789800002539 +PWY_1042_glycolysis_IV diagnosis CD -0.00904154502524878 0.0785489271804965 803 803 0.908567034275942 0.984789800002539 +PWY_5103_L_isoleucine_biosyn_III dysbiosisCD Yes -0.0241702475784504 0.212914480019 803 778 0.909653099040294 0.984789800002539 +PWY_5154_L_arginine_biosyn_III diagnosis CD 0.0382532651000496 0.327540419058938 803 475 0.907227963627654 0.984789800002539 +PWY_7560_methylerythritol_phosphate_pwy_II dysbiosisUC Yes 0.0732749980785176 0.62856839574726 803 226 0.907237582606281 0.984789800002539 +PWYG_321_mycolate_biosyn dysbiosisnonIBD Yes -0.083887580690632 0.747502397111254 803 484 0.910684012628566 0.984789800002539 +THRESYN_PWY_SP_of_L_threonine_biosyn dysbiosisUC Yes 0.0186314359723484 0.153563379614575 803 796 0.903464784246309 0.984789800002539 +NAGLIPASYN_PWY_lipid_IVA_biosyn dysbiosisnonIBD Yes -0.063907471439859 0.606250417758139 803 601 0.916077707558929 0.984789800002539 +PWY_2942_L_lysine_biosyn_III dysbiosisnonIBD Yes 0.0128339730221016 0.122117582254706 803 802 0.916328384306335 0.984789800002539 +PWY_5989_stearate_biosyn_II diagnosis CD 0.046524742357216 0.434797316602115 803 575 0.915099321860714 0.984789800002539 +PWY_6163_chorismate_biosyn_from_3_dehydroquinate age age -0.00831475520387128 0.0793354954446356 803 787 0.916759263424529 0.984789800002539 +PWY_6545_pyrimidine_dnt_de_novo_biosyn_III dysbiosisUC Yes 0.0463037630851323 0.442013366049208 803 651 0.916596796027744 0.984789800002539 +PWY_7234_inosine_5_phosphate_biosyn_III diagnosis CD -0.0356996257287861 0.342608885521639 803 690 0.917249606706621 0.984789800002539 +COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I dysbiosisUC Yes 0.0489850129939788 0.498072644802636 803 578 0.921681201058413 0.984789800002539 +ILEUSYN_PWY_L_isoleucine_biosyn_I diagnosis UC 0.0153579606930412 0.151441326460964 803 773 0.919415577331486 0.984789800002539 +P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate antibiotics Yes -0.0511914485036749 0.513818954560925 803 283 0.920666652322033 0.984789800002539 +PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I antibiotics Yes -0.0428507968521141 0.433592786822102 803 557 0.92130341057953 0.984789800002539 +PWY_5347_SP_of_L_methionine_biosyn dysbiosisnonIBD Yes 0.0666632300563382 0.66400687815527 803 373 0.920061723576432 0.984789800002539 +PWY_5676_acetyl_CoA_fermentation_to_butanoate_II antibiotics Yes 0.0503508570757587 0.494555968772927 803 459 0.91893925994496 0.984789800002539 +PWY_2942_L_lysine_biosyn_III diagnosis UC 0.00822169331261115 0.0863417771194183 803 802 0.924333535036055 0.984789800002539 +PWY_4041_beta_glutamyl_cyc antibiotics Yes -0.0638564257394565 0.666751756084797 803 247 0.923748233610977 0.984789800002539 +PWY_7184_pyrimidine_dnt_de_novo_biosyn_I diagnosis UC 0.020140308506474 0.209599506527507 803 747 0.923635939798955 0.984789800002539 +PWY_841_SP_of_purine_nt_de_novo_biosyn_I dysbiosisCD Yes -0.0354687099128152 0.374979483709945 803 651 0.924679298271023 0.984789800002539 +PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I dysbiosisnonIBD Yes 0.00911292316110222 0.100458835525053 803 799 0.92774457927622 0.984789800002539 +PWY_5659_GDP_mannose_biosyn antibiotics Yes -0.0165680296278958 0.186456264889259 803 788 0.92921853058693 0.984789800002539 +ANAGLYCOLYSIS_PWY_glycolysis_III diagnosis UC -0.00366671912010878 0.0749468889892477 803 801 0.961064770613834 0.984789800002539 +ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn antibiotics Yes -0.00970986470632294 0.174752509677414 803 732 0.95570581971652 0.984789800002539 +BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn dysbiosisnonIBD Yes -0.0185280003926529 0.337636263395083 803 773 0.956252569350686 0.984789800002539 +CALVIN_PWY_Calvin_Benson_Bassham_cyc age age 0.0028250307747398 0.0483535849079464 803 797 0.953536282940553 0.984789800002539 +CITRULBIO_PWY_L_citrulline_biosyn age age -0.0102915095582122 0.157685248949802 803 688 0.948124178211016 0.984789800002539 +COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn age age -0.00328786320852755 0.0631942084067942 803 773 0.958610329296627 0.984789800002539 +DAPLYSINESYN_PWY_L_lysine_biosyn_I dysbiosisnonIBD Yes -0.0365184413843692 0.498447923776997 803 595 0.941617489276076 0.984789800002539 +DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I age age 0.0026927157525363 0.0485274142747117 803 790 0.955854145720015 0.984789800002539 +GALACTUROCAT_PWY_D_galacturonate_deg_I diagnosis CD 0.0139701579885559 0.190738021097872 803 776 0.941748050766134 0.984789800002539 +GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg age age 0.00903079555790363 0.123006584296029 803 757 0.94238116408442 0.984789800002539 +METSYN_PWY_L_homoserine__L_methionine_biosyn dysbiosisnonIBD Yes -0.0296299576088489 0.676453665775451 803 375 0.965076216119191 0.984789800002539 +OANTIGEN_PWY_O_antigen_building_blocks_biosyn diagnosis UC 0.022201336095462 0.342207581230257 803 445 0.948419525225871 0.984789800002539 +PENTOSE_P_PWY_pentose_phosphate_pwy age age -0.0142617818239729 0.140756950010538 803 613 0.931796969010411 0.984789800002539 +PWY_3841_folate_transformations_II antibiotics Yes -0.00587889741429743 0.134694767390562 803 787 0.965197946946259 0.984789800002539 +PWY_4984_urea_cyc diagnosis UC 0.033979674071864 0.463840536863611 803 665 0.941773132832893 0.984789800002539 +PWY_5100_pyruvate_fermentation_to_acetate__lactate_II dysbiosisnonIBD Yes -0.0175701273590698 0.367212394245169 803 778 0.961856278582332 0.984789800002539 +PWY_5103_L_isoleucine_biosyn_III dysbiosisnonIBD Yes -0.0219686776647059 0.341094670576913 803 778 0.948664173906927 0.984789800002539 +PWY_5173_SP_of_acetyl_CoA_biosyn diagnosis UC -0.0355753932702273 0.564735452734261 803 335 0.949897942877657 0.984789800002539 +PWY_5177_glutaryl_CoA_deg dysbiosisnonIBD Yes 0.0265321278236599 0.472837336029449 803 753 0.955267733692656 0.984789800002539 +PWY_5484_glycolysis_II diagnosis UC -0.00674430579131329 0.132519305267702 803 791 0.959534419784122 0.984789800002539 +PWY_5667_CDP_diacylglycerol_biosyn_I diagnosis CD -0.00687907005604373 0.0944266464902206 803 801 0.942052631901902 0.984789800002539 +PWY_5667_CDP_diacylglycerol_biosyn_I age age 0.00223710480371502 0.0374469162812543 803 801 0.952481671603389 0.984789800002539 +PWY_5676_acetyl_CoA_fermentation_to_butanoate_II dysbiosisUC Yes 0.0528622555655047 0.899270247020166 803 459 0.953143410431185 0.984789800002539 +PWY_5676_acetyl_CoA_fermentation_to_butanoate_II dysbiosisnonIBD Yes -0.0470244438469324 0.954473916889749 803 459 0.960721714363611 0.984789800002539 +PWY_5695_urate_biosyn_inosine_5_phosphate_deg dysbiosisCD Yes 0.00531526565096481 0.0948927860002703 803 800 0.95535024703371 0.984789800002539 +PWY_6122_5_aminoimidazole_rnt_biosyn_II dysbiosisnonIBD Yes -0.0102126907486608 0.173300794330065 803 799 0.953024334766873 0.984789800002539 +PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I dysbiosisUC Yes -0.0527136804495012 0.675522418378202 803 561 0.937821959200435 0.984789800002539 +PWY_6270_isoprene_biosyn_I dysbiosisUC Yes -0.0447129679390582 0.629911321140386 803 219 0.943435918602445 0.984789800002539 +PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn dysbiosisnonIBD Yes -0.0102126907486608 0.173300794330065 803 799 0.953024334766873 0.984789800002539 +PWY_6317_galactose_deg_I dysbiosisCD Yes -0.0146466317974404 0.232684184038478 803 765 0.949831955552004 0.984789800002539 +PWY_6703_preQ0_biosyn diagnosis UC 0.0186291792588752 0.237595763615692 803 771 0.937657444415607 0.984789800002539 +PWY_6703_preQ0_biosyn dysbiosisnonIBD Yes -0.0259548427135172 0.380481137907134 803 771 0.945633437455471 0.984789800002539 +PWY_6897_thiamin_salvage_II diagnosis CD 0.0236552419019579 0.305275509080716 803 589 0.938375204799992 0.984789800002539 +PWY_6936_seleno_amino_acid_biosyn dysbiosisnonIBD Yes -0.044671602260631 0.747775865567686 803 472 0.952382029382546 0.984789800002539 +PWY_7111_pyruvate_fermentation_to_isobutanol diagnosis CD 0.00733989811926571 0.100818307630529 803 801 0.942092488751046 0.984789800002539 +PWY_7187_pyrimidine_dnt_de_novo_biosyn_II dysbiosisUC Yes 0.0231454561360517 0.516607354011038 803 647 0.964276390727693 0.984789800002539 +PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisUC Yes -0.0228175932027823 0.517362225481482 803 469 0.96483347162127 0.984789800002539 +PWY_7242_D_fructuronate_deg diagnosis UC 0.00960368967326137 0.214455259351016 803 773 0.964376366207916 0.984789800002539 +PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II dysbiosisnonIBD Yes 0.00846503244491734 0.165363422624747 803 794 0.959187555193766 0.984789800002539 +PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn diagnosis CD 0.0215693060993168 0.484966807225157 803 504 0.964607451718007 0.984789800002539 +PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine dysbiosisUC Yes -0.0345427200079316 0.552469704571401 803 597 0.950161777705723 0.984789800002539 +PWY_7383_anaerobic_energy_metabolism dysbiosisnonIBD Yes 0.0410669941756816 0.621844059067792 803 698 0.947367857759693 0.984789800002539 +PWY_7560_methylerythritol_phosphate_pwy_II age age 0.0156431845568882 0.185250156588861 803 226 0.932876231655402 0.984789800002539 +PWY_841_SP_of_purine_nt_de_novo_biosyn_I antibiotics Yes 0.0229920835137619 0.36555355010609 803 651 0.949866399667036 0.984789800002539 +PWY0_1296_purine_rns_deg antibiotics Yes 0.00973169861644611 0.175983203024678 803 793 0.955915008706363 0.984789800002539 +PWY0_1297_SP_of_purine_dns_deg diagnosis UC -0.0229886002280223 0.392740732173039 803 610 0.953433949502177 0.984789800002539 +PWY0_1319_CDP_diacylglycerol_biosyn_II diagnosis CD -0.00689110670499611 0.0944271394111448 803 801 0.941951722537076 0.984789800002539 +PWY0_1319_CDP_diacylglycerol_biosyn_II age age 0.00223439860209314 0.0374470979525658 803 801 0.95253931540903 0.984789800002539 +PWY0_862_dodec_5_enoate_biosyn dysbiosisnonIBD Yes -0.0575942317987199 0.718208879139642 803 546 0.936109930953414 0.984789800002539 +TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA antibiotics Yes 0.0446587990250192 0.624250003905055 803 159 0.943003788040999 0.984789800002539 +THRESYN_PWY_SP_of_L_threonine_biosyn age age -0.00218551677256896 0.0463347647464155 803 796 0.962475460169742 0.984789800002539 +PWY_5913_TCA_cyc_VI dysbiosisnonIBD Yes -0.0361948451321288 0.864124638016765 803 146 0.966611497113246 0.984789800002539 +PWY_6124_inosine_5_phosphate_biosyn_II dysbiosisUC Yes 0.0101338755792863 0.24077570742712 803 792 0.966439310095027 0.984789800002539 +PWY_2942_L_lysine_biosyn_III diagnosis CD -0.00317529811023003 0.0791404493087426 803 802 0.968072662589936 0.985260686190571 +PWY_7187_pyrimidine_dnt_de_novo_biosyn_II diagnosis UC -0.0144657184520885 0.367108576536889 803 647 0.968655169007584 0.985260686190571 +GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg antibiotics Yes -0.0214212392494533 0.594540021150678 803 300 0.971272204777536 0.987017124679937 +PWY_7383_anaerobic_energy_metabolism dysbiosisUC Yes -0.0230766041427497 0.656431382068104 803 698 0.971966301751431 0.987017124679937 +MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn dysbiosisnonIBD Yes -0.0229715599818644 0.705981670437746 803 375 0.974052957524977 0.988330606739512 +PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg diagnosis UC 0.00726398027323666 0.274168286240751 803 757 0.978916702681962 0.99245745446845 +PWY_7208_SP_of_pyrimidine_nucleobases_salvage age age 0.00136233432243843 0.0568522980052454 803 794 0.980932685427463 0.993692785400503 +PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn dysbiosisUC Yes -0.0162108467485338 0.825898041871749 803 504 0.984345357627835 0.996339817712658 +PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I diagnosis CD -0.00126330976152175 0.0678701510965778 803 799 0.985183272186302 0.996378536642965 +OANTIGEN_PWY_O_antigen_building_blocks_biosyn diagnosis CD -0.00547074483154145 0.319084581590119 803 445 0.986356748895571 0.996427580335131 +GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg dysbiosisnonIBD Yes -0.00543692623202553 0.406707449991647 803 755 0.989338309588555 0.996427580335131 +P441_PWY_SP_of_N_acetylneuraminate_deg diagnosis CD 0.00560708460023859 0.439289087218129 803 433 0.989841468484775 0.996427580335131 +PWY_6124_inosine_5_phosphate_biosyn_II age age 0.00099055423433235 0.0628098031042592 803 792 0.98745327410113 0.996427580335131 +PWY_6703_preQ0_biosyn age age -0.00126621908901822 0.0986952435633908 803 771 0.990029971472626 0.996427580335131 +PWY_6936_seleno_amino_acid_biosyn diagnosis CD 0.00579734783180325 0.402316761242773 803 472 0.988526826645078 0.996427580335131 +ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn diagnosis CD 0.0012134592473513 0.12699565637832 803 797 0.992394362570173 0.997196270776158 +PWY_621_sucrose_deg_III antibiotics Yes 0.00285988359111503 0.287083800395179 803 741 0.992054407038165 0.997196270776158 +HISTSYN_PWY_L_histidine_biosyn dysbiosisnonIBD Yes -0.00291922807580214 0.426620163213396 803 698 0.99454226236801 0.997402989863557 +P42_PWY_incomplete_reductive_TCA_cyc dysbiosisCD Yes -0.00189915231010315 0.36079487182874 803 636 0.995802021982556 0.997402989863557 +PWY_6936_seleno_amino_acid_biosyn antibiotics Yes 0.003337052435108 0.437103927241211 803 472 0.993910767200206 0.997402989863557 +PWY_7237_myo__chiro__scillo_inositol_deg age age 0.00144257797397842 0.247266122651147 803 441 0.995383501890884 0.997402989863557 +P105_PWY_TCA_cyc_IV dysbiosisnonIBD Yes 0.000898048179853703 0.733760971438884 803 101 0.999024201340038 0.999092373917783 +PWY_5723_Rubisco_shunt age age -0.000263909242552383 0.215953579375926 803 212 0.999092373917783 0.999092373917783 diff --git a/test/demo_output/fitted.rds b/test/demo_output/fitted.rds index d320c2a..ecceeef 100644 Binary files a/test/demo_output/fitted.rds and b/test/demo_output/fitted.rds differ diff --git a/test/demo_output/mtx_model.log b/test/demo_output/mtx_model.log index 9f28913..f69b26c 100644 --- a/test/demo_output/mtx_model.log +++ b/test/demo_output/mtx_model.log @@ -1,406 +1,406 @@ -2021-01-26 17:46:44 INFO::Writing function arguments to log file -2021-01-26 17:46:44 DEBUG::Function arguments -2021-01-26 17:46:44 DEBUG::Input data file: ../inst/extdata/HMP2_pwyRNA.tsv -2021-01-26 17:46:44 DEBUG::Input metadata file: ../inst/extdata/HMP2_metadata.tsv -2021-01-26 17:46:44 DEBUG::Output folder: demo_output -2021-01-26 17:46:44 DEBUG::Min Abundance: 0.000000 -2021-01-26 17:46:44 DEBUG::Min Prevalence: 0.000000 -2021-01-26 17:46:44 DEBUG::Normalization: NONE -2021-01-26 17:46:44 DEBUG::Transform: LOG -2021-01-26 17:46:44 DEBUG::Analysis method: LM -2021-01-26 17:46:44 DEBUG::Max significance: 0.250000 -2021-01-26 17:46:44 DEBUG::Random effects: subject,site -2021-01-26 17:46:44 DEBUG::Fixed effects: diagnosis,dysbiosisCD,dysbiosisUC,dysbiosisnonIBD,antibiotics,age -2021-01-26 17:46:44 DEBUG::Correction method: BH -2021-01-26 17:46:44 DEBUG::Standardize: TRUE -2021-01-26 17:46:44 DEBUG::Cores: 1 -2021-01-26 17:46:44 DEBUG::Input dnadata file: ../inst/extdata/HMP2_pwyDNA.tsv -2021-01-26 17:46:44 INFO::Verifying options selected are valid -2021-01-26 17:46:44 INFO::Determining format of input files -2021-01-26 17:46:44 INFO::Input format is data samples as rows and metadata samples as rows -2021-01-26 17:46:44 INFO::Input format is metadata samples as rows and dnadata samples as rows -2021-01-26 17:46:45 DEBUG::A total of 803 samples were found in both the data and metadata -2021-01-26 17:46:45 DEBUG::Reordering data/metadata to use same sample ordering -2021-01-26 17:46:45 INFO::Formula for random effects: expr ~ (1 | subject) + (1 | site) -2021-01-26 17:46:45 INFO::Filter data based on min abundance and min prevalence -2021-01-26 17:46:45 INFO::Total samples in data: 803 -2021-01-26 17:46:45 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000 -2021-01-26 17:46:45 INFO::Total filtered features: 0 -2021-01-26 17:46:45 INFO::Filtered feature names from abundance and prevalence filtering: -2021-01-26 17:46:45 INFO::Total filtered features with variance filtering: 0 -2021-01-26 17:46:45 INFO::Filtered feature names from variance filtering: -2021-01-26 17:46:45 INFO::Running selected normalization method: NONE -2021-01-26 17:46:45 INFO::Applying z-score to standardize continuous metadata -2021-01-26 17:46:45 INFO::Running selected transform method: LOG -2021-01-26 17:46:46 INFO::Running selected analysis method: LM -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + ANAEROFRUCAT_PWY_homolactic_fermentation -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ANAEROFRUCAT_PWY_homolactic_fermentation -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + ANAGLYCOLYSIS_PWY_glycolysis_III -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ANAGLYCOLYSIS_PWY_glycolysis_III -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + ARGSYN_PWY_L_arginine_biosyn_I -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ARGSYN_PWY_L_arginine_biosyn_I -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + ARGSYNBSUB_PWY_L_arginine_biosyn_II -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ARGSYNBSUB_PWY_L_arginine_biosyn_II -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + ARO_PWY_chorismate_biosyn_I -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ARO_PWY_chorismate_biosyn_I -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + CALVIN_PWY_Calvin_Benson_Bassham_cyc -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, CALVIN_PWY_Calvin_Benson_Bassham_cyc -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + CITRULBIO_PWY_L_citrulline_biosyn -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, CITRULBIO_PWY_L_citrulline_biosyn -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + COA_PWY_1_coenzyme_A_biosyn_II -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, COA_PWY_1_coenzyme_A_biosyn_II -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + COA_PWY_coenzyme_A_biosyn_I -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, COA_PWY_coenzyme_A_biosyn_I -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I -2021-01-26 17:46:47 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn -2021-01-26 17:46:47 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + DAPLYSINESYN_PWY_L_lysine_biosyn_I -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, DAPLYSINESYN_PWY_L_lysine_biosyn_I -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + FASYN_ELONG_PWY_fatty_acid_elongation__saturated -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, FASYN_ELONG_PWY_fatty_acid_elongation__saturated -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + FUCCAT_PWY_fucose_deg -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, FUCCAT_PWY_fucose_deg -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + GALACTUROCAT_PWY_D_galacturonate_deg_I -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GALACTUROCAT_PWY_D_galacturonate_deg_I -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + GLUCONEO_PWY_gluconeogenesis_I -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLUCONEO_PWY_gluconeogenesis_I -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + GLYCOGENSYNTH_PWY_glycogen_biosyn_I -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLYCOGENSYNTH_PWY_glycogen_biosyn_I -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + GLYCOLYSIS_glycolysis_I -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLYCOLYSIS_glycolysis_I -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + GLYOXYLATE_BYPASS_glyoxylate_cyc -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLYOXYLATE_BYPASS_glyoxylate_cyc -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + HISDEG_PWY_L_histidine_deg_I -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, HISDEG_PWY_L_histidine_deg_I -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + HISTSYN_PWY_L_histidine_biosyn -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, HISTSYN_PWY_L_histidine_biosyn -2021-01-26 17:46:48 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + ILEUSYN_PWY_L_isoleucine_biosyn_I -2021-01-26 17:46:48 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ILEUSYN_PWY_L_isoleucine_biosyn_I -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + METSYN_PWY_L_homoserine__L_methionine_biosyn -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, METSYN_PWY_L_homoserine__L_methionine_biosyn -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + NAGLIPASYN_PWY_lipid_IVA_biosyn -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, NAGLIPASYN_PWY_lipid_IVA_biosyn -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + NONOXIPENT_PWY_pentose_phosphate_pwy -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, NONOXIPENT_PWY_pentose_phosphate_pwy -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + OANTIGEN_PWY_O_antigen_building_blocks_biosyn -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, OANTIGEN_PWY_O_antigen_building_blocks_biosyn -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + P105_PWY_TCA_cyc_IV -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P105_PWY_TCA_cyc_IV -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + P108_PWY_pyruvate_fermentation_to_propanoate_I -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P108_PWY_pyruvate_fermentation_to_propanoate_I -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + P161_PWY_acetylene_deg -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P161_PWY_acetylene_deg -2021-01-26 17:46:49 WARNING::Feature name not found in dnadata so not applied to formula with effects: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site -2021-01-26 17:46:49 WARNING::Feature name not found in dnadata so not applied to formula with effects: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site -2021-01-26 17:46:49 WARNING::Feature name not found in dnadata so not applied to formula with effects: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + P42_PWY_incomplete_reductive_TCA_cyc -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P42_PWY_incomplete_reductive_TCA_cyc -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + P441_PWY_SP_of_N_acetylneuraminate_deg -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P441_PWY_SP_of_N_acetylneuraminate_deg -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PANTO_PWY_phosphopantothenate_biosyn_I -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PANTO_PWY_phosphopantothenate_biosyn_I -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PENTOSE_P_PWY_pentose_phosphate_pwy -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PENTOSE_P_PWY_pentose_phosphate_pwy -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_1042_glycolysis_IV -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_1042_glycolysis_IV -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_2941_L_lysine_biosyn_II -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_2941_L_lysine_biosyn_II -2021-01-26 17:46:49 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_2942_L_lysine_biosyn_III -2021-01-26 17:46:49 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_2942_L_lysine_biosyn_III -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_3001_SP_of_L_isoleucine_biosyn_I -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_3001_SP_of_L_isoleucine_biosyn_I -2021-01-26 17:46:50 WARNING::Feature name not found in dnadata so not applied to formula as fixed effect: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site -2021-01-26 17:46:50 WARNING::Feature name not found in dnadata so not applied to formula as fixed effect: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_3841_folate_transformations_II -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_3841_folate_transformations_II -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_4041_beta_glutamyl_cyc -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_4041_beta_glutamyl_cyc -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_4242_pantothenate__coenzyme_A_biosyn_III -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_4242_pantothenate__coenzyme_A_biosyn_III -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_4981_L_proline_biosyn_II -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_4981_L_proline_biosyn_II -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_4984_urea_cyc -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_4984_urea_cyc -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5030_L_histidine_deg_III -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5030_L_histidine_deg_III -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5083_NAD_NADH_phosphorylation__dephosphorylation -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5083_NAD_NADH_phosphorylation__dephosphorylation -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5097_L_lysine_biosyn_VI -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5097_L_lysine_biosyn_VI -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5100_pyruvate_fermentation_to_acetate__lactate_II -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5100_pyruvate_fermentation_to_acetate__lactate_II -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5101_L_isoleucine_biosyn_II -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5101_L_isoleucine_biosyn_II -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5103_L_isoleucine_biosyn_III -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5103_L_isoleucine_biosyn_III -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5104_L_isoleucine_biosyn_IV -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5104_L_isoleucine_biosyn_IV -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5154_L_arginine_biosyn_III -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5154_L_arginine_biosyn_III -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5173_SP_of_acetyl_CoA_biosyn -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5173_SP_of_acetyl_CoA_biosyn -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5177_glutaryl_CoA_deg -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5177_glutaryl_CoA_deg -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5188_tetrapyrrole_biosyn_I -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5188_tetrapyrrole_biosyn_I -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5347_SP_of_L_methionine_biosyn -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5347_SP_of_L_methionine_biosyn -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5484_glycolysis_II -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5484_glycolysis_II -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5659_GDP_mannose_biosyn -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5659_GDP_mannose_biosyn -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5667_CDP_diacylglycerol_biosyn_I -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5667_CDP_diacylglycerol_biosyn_I -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5676_acetyl_CoA_fermentation_to_butanoate_II -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5676_acetyl_CoA_fermentation_to_butanoate_II -2021-01-26 17:46:50 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5686_UMP_biosyn -2021-01-26 17:46:50 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5686_UMP_biosyn -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5690_TCA_cyc_II -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5690_TCA_cyc_II -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5695_urate_biosyn_inosine_5_phosphate_deg -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5695_urate_biosyn_inosine_5_phosphate_deg -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5723_Rubisco_shunt -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5723_Rubisco_shunt -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5913_TCA_cyc_VI -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5913_TCA_cyc_VI -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5971_palmitate_biosyn_II -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5971_palmitate_biosyn_II -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5973_cis_vaccenate_biosyn -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5973_cis_vaccenate_biosyn -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_5989_stearate_biosyn_II -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5989_stearate_biosyn_II -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6121_5_aminoimidazole_rnt_biosyn_I -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6121_5_aminoimidazole_rnt_biosyn_I -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6122_5_aminoimidazole_rnt_biosyn_II -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6122_5_aminoimidazole_rnt_biosyn_II -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6123_inosine_5_phosphate_biosyn_I -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6123_inosine_5_phosphate_biosyn_I -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6124_inosine_5_phosphate_biosyn_II -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6124_inosine_5_phosphate_biosyn_II -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6151_S_adenosyl_L_methionine_cyc_I -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6151_S_adenosyl_L_methionine_cyc_I -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6163_chorismate_biosyn_from_3_dehydroquinate -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6163_chorismate_biosyn_from_3_dehydroquinate -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6168_flavin_biosyn_III -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6168_flavin_biosyn_III -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_621_sucrose_deg_III -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_621_sucrose_deg_III -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6270_isoprene_biosyn_I -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6270_isoprene_biosyn_I -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6282_palmitoleate_biosyn_I -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6282_palmitoleate_biosyn_I -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6317_galactose_deg_I -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6317_galactose_deg_I -2021-01-26 17:46:51 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6353_purine_nt_deg_II -2021-01-26 17:46:51 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6353_purine_nt_deg_II -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6385_peptidoglycan_biosyn_III -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6385_peptidoglycan_biosyn_III -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6527_stachyose_deg -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6527_stachyose_deg -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6545_pyrimidine_dnt_de_novo_biosyn_III -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6545_pyrimidine_dnt_de_novo_biosyn_III -2021-01-26 17:46:52 WARNING::Feature name not found in dnadata so not applied to formula as fixed effect: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6608_guanosine_nt_deg_III -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6608_guanosine_nt_deg_III -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6609_adenine__adenosine_salvage_III -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6609_adenine__adenosine_salvage_III -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6700_queuosine_biosyn -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6700_queuosine_biosyn -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6703_preQ0_biosyn -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6703_preQ0_biosyn -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6737_starch_deg_V -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6737_starch_deg_V -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6897_thiamin_salvage_II -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6897_thiamin_salvage_II -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6901_SP_of_glucose__xylose_deg -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6901_SP_of_glucose__xylose_deg -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6936_seleno_amino_acid_biosyn -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6936_seleno_amino_acid_biosyn -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_6969_TCA_cyc_V -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6969_TCA_cyc_V -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7111_pyruvate_fermentation_to_isobutanol -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7111_pyruvate_fermentation_to_isobutanol -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7184_pyrimidine_dnt_de_novo_biosyn_I -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7184_pyrimidine_dnt_de_novo_biosyn_I -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7187_pyrimidine_dnt_de_novo_biosyn_II -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7187_pyrimidine_dnt_de_novo_biosyn_II -2021-01-26 17:46:52 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7196_SP_of_pyrimidine_rns_salvage -2021-01-26 17:46:52 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7196_SP_of_pyrimidine_rns_salvage -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7197_pyrimidine_dnt_phosphorylation -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7197_pyrimidine_dnt_phosphorylation -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7199_pyrimidine_dns_salvage -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7199_pyrimidine_dns_salvage -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7208_SP_of_pyrimidine_nucleobases_salvage -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7208_SP_of_pyrimidine_nucleobases_salvage -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7219_adenosine_rnt_de_novo_biosyn -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7219_adenosine_rnt_de_novo_biosyn -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7220_adenosine_dnt_de_novo_biosyn_II -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7220_adenosine_dnt_de_novo_biosyn_II -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7221_guanosine_rnt_de_novo_biosyn -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7221_guanosine_rnt_de_novo_biosyn -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7222_guanosine_dnt_de_novo_biosyn_II -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7222_guanosine_dnt_de_novo_biosyn_II -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7234_inosine_5_phosphate_biosyn_III -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7234_inosine_5_phosphate_biosyn_III -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7237_myo__chiro__scillo_inositol_deg -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7237_myo__chiro__scillo_inositol_deg -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7242_D_fructuronate_deg -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7242_D_fructuronate_deg -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II -2021-01-26 17:46:53 WARNING::Feature name not found in dnadata so not applied to formula as fixed effect: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn -2021-01-26 17:46:53 WARNING::Feature name not found in dnadata so not applied to formula as fixed effect: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7383_anaerobic_energy_metabolism -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7383_anaerobic_energy_metabolism -2021-01-26 17:46:53 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7388_octanoyl_acyl_carrier_protein_biosyn -2021-01-26 17:46:53 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7388_octanoyl_acyl_carrier_protein_biosyn -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7400_L_arginine_biosyn_IV -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7400_L_arginine_biosyn_IV -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7456_mannan_deg -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7456_mannan_deg -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7560_methylerythritol_phosphate_pwy_II -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7560_methylerythritol_phosphate_pwy_II -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7663_gondoate_biosyn -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7663_gondoate_biosyn -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_7664_oleate_biosyn_IV -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7664_oleate_biosyn_IV -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY_841_SP_of_purine_nt_de_novo_biosyn_I -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_841_SP_of_purine_nt_de_novo_biosyn_I -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY0_1261_anhydromuropeptides_recycling -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1261_anhydromuropeptides_recycling -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY0_1296_purine_rns_deg -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1296_purine_rns_deg -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY0_1297_SP_of_purine_dns_deg -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1297_SP_of_purine_dns_deg -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY0_1298_SP_of_pyrimidine_dns_deg -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1298_SP_of_pyrimidine_dns_deg -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY0_1319_CDP_diacylglycerol_biosyn_II -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1319_CDP_diacylglycerol_biosyn_II -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY0_1479_tRNA_processing -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1479_tRNA_processing -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY0_1586_peptidoglycan_maturation -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1586_peptidoglycan_maturation -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY0_862_dodec_5_enoate_biosyn -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_862_dodec_5_enoate_biosyn -2021-01-26 17:46:54 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY4FS_7_phosphatidylglycerol_biosyn_I -2021-01-26 17:46:54 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY4FS_7_phosphatidylglycerol_biosyn_I -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY4FS_8_phosphatidylglycerol_biosyn_II -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY4FS_8_phosphatidylglycerol_biosyn_II -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY66_399_gluconeogenesis_III -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY66_399_gluconeogenesis_III -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY66_400_glycolysis_VI -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY66_400_glycolysis_VI -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY66_409_SP_of_purine_nt_salvage -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY66_409_SP_of_purine_nt_salvage -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWY66_422_D_galactose_deg_V -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY66_422_D_galactose_deg_V -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PWYG_321_mycolate_biosyn -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWYG_321_mycolate_biosyn -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PYRIDNUCSYN_PWY_NAD_biosyn_I -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PYRIDNUCSYN_PWY_NAD_biosyn_I -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + RHAMCAT_PWY_L_rhamnose_deg_I -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, RHAMCAT_PWY_L_rhamnose_deg_I -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + RIBOSYN2_PWY_flavin_biosyn_I -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, RIBOSYN2_PWY_flavin_biosyn_I -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + SALVADEHYPOX_PWY_adenosine_nt_deg_II -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, SALVADEHYPOX_PWY_adenosine_nt_deg_II -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + TCA_TCA_cyc_I -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, TCA_TCA_cyc_I -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + THRESYN_PWY_SP_of_L_threonine_biosyn -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, THRESYN_PWY_SP_of_L_threonine_biosyn -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + TRNA_CHARGING_PWY_tRNA_charging -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, TRNA_CHARGING_PWY_tRNA_charging -2021-01-26 17:46:55 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I -2021-01-26 17:46:55 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I -2021-01-26 17:46:56 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + subject + site + VALSYN_PWY_L_valine_biosyn -2021-01-26 17:46:56 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, VALSYN_PWY_L_valine_biosyn -2021-01-26 17:46:59 INFO::Counting total values for each feature -2021-01-26 17:47:01 INFO::Writing residuals to file demo_output/residuals.rds -2021-01-26 17:47:01 INFO::Writing fitted values to file demo_output/fitted.rds -2021-01-26 17:47:01 INFO::Writing extracted random effects to file demo_output/ranef.rds -2021-01-26 17:47:01 INFO::Writing all results to file (ordered by increasing q-values): demo_output/all_results.tsv -2021-01-26 17:47:01 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): demo_output/significant_results.tsv -2021-01-26 17:47:01 INFO::Writing association plots (one for each significant association) to output folder: demo_output +2024-07-10 18:33:13 INFO::Writing function arguments to log file +2024-07-10 18:33:13 DEBUG::Function arguments +2024-07-10 18:33:13 DEBUG::Input data file: ../inst/extdata/HMP2_pwyRNA.tsv +2024-07-10 18:33:13 DEBUG::Input metadata file: ../inst/extdata/HMP2_metadata.tsv +2024-07-10 18:33:13 DEBUG::Output folder: demo_output +2024-07-10 18:33:13 DEBUG::Min Abundance: 0.000000 +2024-07-10 18:33:13 DEBUG::Min Prevalence: 0.000000 +2024-07-10 18:33:13 DEBUG::Normalization: NONE +2024-07-10 18:33:13 DEBUG::Transform: LOG +2024-07-10 18:33:13 DEBUG::Analysis method: LM +2024-07-10 18:33:13 DEBUG::Max significance: 0.250000 +2024-07-10 18:33:13 DEBUG::Random effects: subject,site +2024-07-10 18:33:13 DEBUG::Fixed effects: diagnosis,dysbiosisCD,dysbiosisUC,dysbiosisnonIBD,antibiotics,age +2024-07-10 18:33:13 DEBUG::Correction method: BH +2024-07-10 18:33:13 DEBUG::Standardize: TRUE +2024-07-10 18:33:13 DEBUG::Cores: 1 +2024-07-10 18:33:13 DEBUG::Input dnadata file: ../inst/extdata/HMP2_pwyDNA.tsv +2024-07-10 18:33:13 INFO::Verifying options selected are valid +2024-07-10 18:33:13 INFO::Determining format of input files +2024-07-10 18:33:13 INFO::Input format is data samples as rows and metadata samples as rows +2024-07-10 18:33:13 INFO::Input format is dnadata samples as rows and metadata samples as rows +2024-07-10 18:33:13 DEBUG::A total of 803 samples were found in both the data and metadata +2024-07-10 18:33:13 DEBUG::Reordering data/metadata to use same sample ordering +2024-07-10 18:33:13 INFO::Formula for random effects: expr ~ (1 | subject) + (1 | site) +2024-07-10 18:33:13 INFO::Formula for fixed effects: expr ~ diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age +2024-07-10 18:33:13 INFO::Filter data based on min abundance and min prevalence +2024-07-10 18:33:13 INFO::Total samples in data: 803 +2024-07-10 18:33:13 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000 +2024-07-10 18:33:13 INFO::Total filtered features: 0 +2024-07-10 18:33:13 INFO::Filtered feature names from abundance and prevalence filtering: +2024-07-10 18:33:13 INFO::Total filtered features with variance filtering: 0 +2024-07-10 18:33:13 INFO::Filtered feature names from variance filtering: +2024-07-10 18:33:13 INFO::Running selected normalization method: NONE +2024-07-10 18:33:13 INFO::Applying z-score to standardize continuous metadata +2024-07-10 18:33:13 INFO::Running selected transform method: LOG +2024-07-10 18:33:13 INFO::Running selected analysis method: LM +2024-07-10 18:33:14 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:14 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn +2024-07-10 18:33:14 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + ANAEROFRUCAT_PWY_homolactic_fermentation + (1 | subject) + (1 | site) +2024-07-10 18:33:14 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ANAEROFRUCAT_PWY_homolactic_fermentation +2024-07-10 18:33:14 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + ANAGLYCOLYSIS_PWY_glycolysis_III + (1 | subject) + (1 | site) +2024-07-10 18:33:14 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ANAGLYCOLYSIS_PWY_glycolysis_III +2024-07-10 18:33:15 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:15 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn +2024-07-10 18:33:15 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + ARGSYN_PWY_L_arginine_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:15 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ARGSYN_PWY_L_arginine_biosyn_I +2024-07-10 18:33:15 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + ARGSYNBSUB_PWY_L_arginine_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:15 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ARGSYNBSUB_PWY_L_arginine_biosyn_II +2024-07-10 18:33:15 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + ARO_PWY_chorismate_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:15 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ARO_PWY_chorismate_biosyn_I +2024-07-10 18:33:16 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:16 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn +2024-07-10 18:33:16 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:16 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, BRANCHED_CHAIN_AA_SYN_PWY_SP_of_branched_amino_acid_biosyn +2024-07-10 18:33:16 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + CALVIN_PWY_Calvin_Benson_Bassham_cyc + (1 | subject) + (1 | site) +2024-07-10 18:33:16 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, CALVIN_PWY_Calvin_Benson_Bassham_cyc +2024-07-10 18:33:16 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + CITRULBIO_PWY_L_citrulline_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:16 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, CITRULBIO_PWY_L_citrulline_biosyn +2024-07-10 18:33:16 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + COA_PWY_1_coenzyme_A_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:16 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, COA_PWY_1_coenzyme_A_biosyn_II +2024-07-10 18:33:16 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + COA_PWY_coenzyme_A_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:16 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, COA_PWY_coenzyme_A_biosyn_I +2024-07-10 18:33:16 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I + (1 | subject) + (1 | site) +2024-07-10 18:33:16 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, COBALSYN_PWY_adenosylcobalamin_salvage_from_cobinamide_I +2024-07-10 18:33:16 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:16 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn +2024-07-10 18:33:17 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + DAPLYSINESYN_PWY_L_lysine_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:17 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, DAPLYSINESYN_PWY_L_lysine_biosyn_I +2024-07-10 18:33:17 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:17 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, DENOVOPURINE2_PWY_SP_of_purine_nt_de_novo_biosyn_II +2024-07-10 18:33:17 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:17 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I +2024-07-10 18:33:17 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + FASYN_ELONG_PWY_fatty_acid_elongation__saturated + (1 | subject) + (1 | site) +2024-07-10 18:33:17 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, FASYN_ELONG_PWY_fatty_acid_elongation__saturated +2024-07-10 18:33:17 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation + (1 | subject) + (1 | site) +2024-07-10 18:33:17 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation +2024-07-10 18:33:17 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + FUCCAT_PWY_fucose_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:17 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, FUCCAT_PWY_fucose_deg +2024-07-10 18:33:18 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:18 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg +2024-07-10 18:33:18 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + GALACTUROCAT_PWY_D_galacturonate_deg_I + (1 | subject) + (1 | site) +2024-07-10 18:33:18 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GALACTUROCAT_PWY_D_galacturonate_deg_I +2024-07-10 18:33:18 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:18 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg +2024-07-10 18:33:18 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + GLUCONEO_PWY_gluconeogenesis_I + (1 | subject) + (1 | site) +2024-07-10 18:33:18 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLUCONEO_PWY_gluconeogenesis_I +2024-07-10 18:33:18 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:18 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg +2024-07-10 18:33:18 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:18 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg +2024-07-10 18:33:18 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + GLYCOGENSYNTH_PWY_glycogen_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:18 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLYCOGENSYNTH_PWY_glycogen_biosyn_I +2024-07-10 18:33:19 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff + (1 | subject) + (1 | site) +2024-07-10 18:33:19 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLYCOLYSIS_E_D_SP_of_glycolysis__Entner_Doudoroff +2024-07-10 18:33:19 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + GLYCOLYSIS_glycolysis_I + (1 | subject) + (1 | site) +2024-07-10 18:33:19 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLYCOLYSIS_glycolysis_I +2024-07-10 18:33:19 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + GLYOXYLATE_BYPASS_glyoxylate_cyc + (1 | subject) + (1 | site) +2024-07-10 18:33:19 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, GLYOXYLATE_BYPASS_glyoxylate_cyc +2024-07-10 18:33:19 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + HISDEG_PWY_L_histidine_deg_I + (1 | subject) + (1 | site) +2024-07-10 18:33:19 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, HISDEG_PWY_L_histidine_deg_I +2024-07-10 18:33:19 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + HISTSYN_PWY_L_histidine_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:19 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, HISTSYN_PWY_L_histidine_biosyn +2024-07-10 18:33:19 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + ILEUSYN_PWY_L_isoleucine_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:19 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, ILEUSYN_PWY_L_isoleucine_biosyn_I +2024-07-10 18:33:19 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:19 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, MET_SAM_PWY_SP_of_S_adenosyl_L_methionine_biosyn +2024-07-10 18:33:20 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + METSYN_PWY_L_homoserine__L_methionine_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:20 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, METSYN_PWY_L_homoserine__L_methionine_biosyn +2024-07-10 18:33:20 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + NAGLIPASYN_PWY_lipid_IVA_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:20 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, NAGLIPASYN_PWY_lipid_IVA_biosyn +2024-07-10 18:33:20 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I + (1 | subject) + (1 | site) +2024-07-10 18:33:20 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I +2024-07-10 18:33:20 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + NONOXIPENT_PWY_pentose_phosphate_pwy + (1 | subject) + (1 | site) +2024-07-10 18:33:20 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, NONOXIPENT_PWY_pentose_phosphate_pwy +2024-07-10 18:33:20 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + OANTIGEN_PWY_O_antigen_building_blocks_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:20 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, OANTIGEN_PWY_O_antigen_building_blocks_biosyn +2024-07-10 18:33:20 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + P105_PWY_TCA_cyc_IV + (1 | subject) + (1 | site) +2024-07-10 18:33:20 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P105_PWY_TCA_cyc_IV +2024-07-10 18:33:20 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + P108_PWY_pyruvate_fermentation_to_propanoate_I + (1 | subject) + (1 | site) +2024-07-10 18:33:20 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P108_PWY_pyruvate_fermentation_to_propanoate_I +2024-07-10 18:33:21 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + P161_PWY_acetylene_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:21 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P161_PWY_acetylene_deg +2024-07-10 18:33:21 WARNING::Feature name not found in dnadata so not applied to formula with effects: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site +2024-07-10 18:33:21 WARNING::Feature name not found in dnadata so not applied to formula with effects: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site +2024-07-10 18:33:21 WARNING::Feature name not found in dnadata so not applied to formula with effects: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site +2024-07-10 18:33:21 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + P42_PWY_incomplete_reductive_TCA_cyc + (1 | subject) + (1 | site) +2024-07-10 18:33:21 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P42_PWY_incomplete_reductive_TCA_cyc +2024-07-10 18:33:21 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + P441_PWY_SP_of_N_acetylneuraminate_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:21 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P441_PWY_SP_of_N_acetylneuraminate_deg +2024-07-10 18:33:21 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate + (1 | subject) + (1 | site) +2024-07-10 18:33:21 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate +2024-07-10 18:33:21 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PANTO_PWY_phosphopantothenate_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:21 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PANTO_PWY_phosphopantothenate_biosyn_I +2024-07-10 18:33:21 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:21 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I +2024-07-10 18:33:21 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PENTOSE_P_PWY_pentose_phosphate_pwy + (1 | subject) + (1 | site) +2024-07-10 18:33:21 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PENTOSE_P_PWY_pentose_phosphate_pwy +2024-07-10 18:33:22 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:22 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I +2024-07-10 18:33:22 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:22 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I +2024-07-10 18:33:22 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:22 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PRPP_PWY_SP_of_histidine_purine__pyrimidine_biosyn +2024-07-10 18:33:22 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_1042_glycolysis_IV + (1 | subject) + (1 | site) +2024-07-10 18:33:22 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_1042_glycolysis_IV +2024-07-10 18:33:22 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:22 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I +2024-07-10 18:33:22 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_2941_L_lysine_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:22 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_2941_L_lysine_biosyn_II +2024-07-10 18:33:22 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_2942_L_lysine_biosyn_III + (1 | subject) + (1 | site) +2024-07-10 18:33:22 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_2942_L_lysine_biosyn_III +2024-07-10 18:33:23 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_3001_SP_of_L_isoleucine_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:23 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_3001_SP_of_L_isoleucine_biosyn_I +2024-07-10 18:33:23 WARNING::Feature name not found in dnadata so not applied to formula with effects: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site +2024-07-10 18:33:23 WARNING::Feature name not found in dnadata so not applied to formula with effects: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site +2024-07-10 18:33:23 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_3841_folate_transformations_II + (1 | subject) + (1 | site) +2024-07-10 18:33:23 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_3841_folate_transformations_II +2024-07-10 18:33:23 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_4041_beta_glutamyl_cyc + (1 | subject) + (1 | site) +2024-07-10 18:33:23 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_4041_beta_glutamyl_cyc +2024-07-10 18:33:23 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_4242_pantothenate__coenzyme_A_biosyn_III + (1 | subject) + (1 | site) +2024-07-10 18:33:23 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_4242_pantothenate__coenzyme_A_biosyn_III +2024-07-10 18:33:23 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_4981_L_proline_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:23 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_4981_L_proline_biosyn_II +2024-07-10 18:33:24 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_4984_urea_cyc + (1 | subject) + (1 | site) +2024-07-10 18:33:24 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_4984_urea_cyc +2024-07-10 18:33:24 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5030_L_histidine_deg_III + (1 | subject) + (1 | site) +2024-07-10 18:33:24 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5030_L_histidine_deg_III +2024-07-10 18:33:24 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5083_NAD_NADH_phosphorylation__dephosphorylation + (1 | subject) + (1 | site) +2024-07-10 18:33:24 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5083_NAD_NADH_phosphorylation__dephosphorylation +2024-07-10 18:33:24 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5097_L_lysine_biosyn_VI + (1 | subject) + (1 | site) +2024-07-10 18:33:24 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5097_L_lysine_biosyn_VI +2024-07-10 18:33:24 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5100_pyruvate_fermentation_to_acetate__lactate_II + (1 | subject) + (1 | site) +2024-07-10 18:33:24 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5100_pyruvate_fermentation_to_acetate__lactate_II +2024-07-10 18:33:24 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5101_L_isoleucine_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:24 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5101_L_isoleucine_biosyn_II +2024-07-10 18:33:25 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5103_L_isoleucine_biosyn_III + (1 | subject) + (1 | site) +2024-07-10 18:33:25 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5103_L_isoleucine_biosyn_III +2024-07-10 18:33:25 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5104_L_isoleucine_biosyn_IV + (1 | subject) + (1 | site) +2024-07-10 18:33:25 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5104_L_isoleucine_biosyn_IV +2024-07-10 18:33:25 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5154_L_arginine_biosyn_III + (1 | subject) + (1 | site) +2024-07-10 18:33:25 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5154_L_arginine_biosyn_III +2024-07-10 18:33:25 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5173_SP_of_acetyl_CoA_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:25 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5173_SP_of_acetyl_CoA_biosyn +2024-07-10 18:33:25 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5177_glutaryl_CoA_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:25 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5177_glutaryl_CoA_deg +2024-07-10 18:33:25 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5188_tetrapyrrole_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:25 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5188_tetrapyrrole_biosyn_I +2024-07-10 18:33:25 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5347_SP_of_L_methionine_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:25 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5347_SP_of_L_methionine_biosyn +2024-07-10 18:33:26 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5484_glycolysis_II + (1 | subject) + (1 | site) +2024-07-10 18:33:26 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5484_glycolysis_II +2024-07-10 18:33:26 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5659_GDP_mannose_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:26 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5659_GDP_mannose_biosyn +2024-07-10 18:33:26 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5667_CDP_diacylglycerol_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:26 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5667_CDP_diacylglycerol_biosyn_I +2024-07-10 18:33:26 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5676_acetyl_CoA_fermentation_to_butanoate_II + (1 | subject) + (1 | site) +2024-07-10 18:33:26 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5676_acetyl_CoA_fermentation_to_butanoate_II +2024-07-10 18:33:26 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5686_UMP_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:26 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5686_UMP_biosyn +2024-07-10 18:33:26 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5690_TCA_cyc_II + (1 | subject) + (1 | site) +2024-07-10 18:33:26 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5690_TCA_cyc_II +2024-07-10 18:33:27 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5695_urate_biosyn_inosine_5_phosphate_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:27 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5695_urate_biosyn_inosine_5_phosphate_deg +2024-07-10 18:33:27 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5723_Rubisco_shunt + (1 | subject) + (1 | site) +2024-07-10 18:33:27 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5723_Rubisco_shunt +2024-07-10 18:33:27 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5913_TCA_cyc_VI + (1 | subject) + (1 | site) +2024-07-10 18:33:27 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5913_TCA_cyc_VI +2024-07-10 18:33:27 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5971_palmitate_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:27 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5971_palmitate_biosyn_II +2024-07-10 18:33:27 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5973_cis_vaccenate_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:27 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5973_cis_vaccenate_biosyn +2024-07-10 18:33:27 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_5989_stearate_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:27 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_5989_stearate_biosyn_II +2024-07-10 18:33:27 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6121_5_aminoimidazole_rnt_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:27 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6121_5_aminoimidazole_rnt_biosyn_I +2024-07-10 18:33:27 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6122_5_aminoimidazole_rnt_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:27 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6122_5_aminoimidazole_rnt_biosyn_II +2024-07-10 18:33:28 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6123_inosine_5_phosphate_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:28 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6123_inosine_5_phosphate_biosyn_I +2024-07-10 18:33:28 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6124_inosine_5_phosphate_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:28 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6124_inosine_5_phosphate_biosyn_II +2024-07-10 18:33:28 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:28 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II +2024-07-10 18:33:28 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:28 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II +2024-07-10 18:33:28 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:28 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I +2024-07-10 18:33:28 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6151_S_adenosyl_L_methionine_cyc_I + (1 | subject) + (1 | site) +2024-07-10 18:33:28 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6151_S_adenosyl_L_methionine_cyc_I +2024-07-10 18:33:29 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6163_chorismate_biosyn_from_3_dehydroquinate + (1 | subject) + (1 | site) +2024-07-10 18:33:29 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6163_chorismate_biosyn_from_3_dehydroquinate +2024-07-10 18:33:29 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6168_flavin_biosyn_III + (1 | subject) + (1 | site) +2024-07-10 18:33:29 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6168_flavin_biosyn_III +2024-07-10 18:33:29 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_621_sucrose_deg_III + (1 | subject) + (1 | site) +2024-07-10 18:33:29 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_621_sucrose_deg_III +2024-07-10 18:33:29 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6270_isoprene_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:29 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6270_isoprene_biosyn_I +2024-07-10 18:33:29 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:29 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6277_SP_of_5_aminoimidazole_rnt_biosyn +2024-07-10 18:33:29 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6282_palmitoleate_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:29 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6282_palmitoleate_biosyn_I +2024-07-10 18:33:29 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6317_galactose_deg_I + (1 | subject) + (1 | site) +2024-07-10 18:33:29 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6317_galactose_deg_I +2024-07-10 18:33:30 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6353_purine_nt_deg_II + (1 | subject) + (1 | site) +2024-07-10 18:33:30 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6353_purine_nt_deg_II +2024-07-10 18:33:30 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6385_peptidoglycan_biosyn_III + (1 | subject) + (1 | site) +2024-07-10 18:33:30 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6385_peptidoglycan_biosyn_III +2024-07-10 18:33:30 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:30 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II +2024-07-10 18:33:30 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:30 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I +2024-07-10 18:33:30 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:30 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg +2024-07-10 18:33:30 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6527_stachyose_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:30 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6527_stachyose_deg +2024-07-10 18:33:30 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6545_pyrimidine_dnt_de_novo_biosyn_III + (1 | subject) + (1 | site) +2024-07-10 18:33:30 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6545_pyrimidine_dnt_de_novo_biosyn_III +2024-07-10 18:33:31 WARNING::Feature name not found in dnadata so not applied to formula with effects: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site +2024-07-10 18:33:31 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6608_guanosine_nt_deg_III + (1 | subject) + (1 | site) +2024-07-10 18:33:31 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6608_guanosine_nt_deg_III +2024-07-10 18:33:31 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6609_adenine__adenosine_salvage_III + (1 | subject) + (1 | site) +2024-07-10 18:33:31 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6609_adenine__adenosine_salvage_III +2024-07-10 18:33:31 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6700_queuosine_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:31 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6700_queuosine_biosyn +2024-07-10 18:33:31 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6703_preQ0_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:31 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6703_preQ0_biosyn +2024-07-10 18:33:31 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6737_starch_deg_V + (1 | subject) + (1 | site) +2024-07-10 18:33:31 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6737_starch_deg_V +2024-07-10 18:33:31 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6897_thiamin_salvage_II + (1 | subject) + (1 | site) +2024-07-10 18:33:31 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6897_thiamin_salvage_II +2024-07-10 18:33:31 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6901_SP_of_glucose__xylose_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:31 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6901_SP_of_glucose__xylose_deg +2024-07-10 18:33:32 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6936_seleno_amino_acid_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:32 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6936_seleno_amino_acid_biosyn +2024-07-10 18:33:32 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_6969_TCA_cyc_V + (1 | subject) + (1 | site) +2024-07-10 18:33:32 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_6969_TCA_cyc_V +2024-07-10 18:33:32 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7111_pyruvate_fermentation_to_isobutanol + (1 | subject) + (1 | site) +2024-07-10 18:33:32 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7111_pyruvate_fermentation_to_isobutanol +2024-07-10 18:33:32 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7184_pyrimidine_dnt_de_novo_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:32 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7184_pyrimidine_dnt_de_novo_biosyn_I +2024-07-10 18:33:32 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7187_pyrimidine_dnt_de_novo_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:32 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7187_pyrimidine_dnt_de_novo_biosyn_II +2024-07-10 18:33:32 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7196_SP_of_pyrimidine_rns_salvage + (1 | subject) + (1 | site) +2024-07-10 18:33:32 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7196_SP_of_pyrimidine_rns_salvage +2024-07-10 18:33:33 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7197_pyrimidine_dnt_phosphorylation + (1 | subject) + (1 | site) +2024-07-10 18:33:33 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7197_pyrimidine_dnt_phosphorylation +2024-07-10 18:33:33 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7199_pyrimidine_dns_salvage + (1 | subject) + (1 | site) +2024-07-10 18:33:33 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7199_pyrimidine_dns_salvage +2024-07-10 18:33:33 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7208_SP_of_pyrimidine_nucleobases_salvage + (1 | subject) + (1 | site) +2024-07-10 18:33:33 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7208_SP_of_pyrimidine_nucleobases_salvage +2024-07-10 18:33:33 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:33 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn +2024-07-10 18:33:33 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7219_adenosine_rnt_de_novo_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:33 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7219_adenosine_rnt_de_novo_biosyn +2024-07-10 18:33:33 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7220_adenosine_dnt_de_novo_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:33 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7220_adenosine_dnt_de_novo_biosyn_II +2024-07-10 18:33:33 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7221_guanosine_rnt_de_novo_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:33 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7221_guanosine_rnt_de_novo_biosyn +2024-07-10 18:33:34 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7222_guanosine_dnt_de_novo_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:34 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7222_guanosine_dnt_de_novo_biosyn_II +2024-07-10 18:33:34 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:34 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I +2024-07-10 18:33:34 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:34 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I +2024-07-10 18:33:34 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7234_inosine_5_phosphate_biosyn_III + (1 | subject) + (1 | site) +2024-07-10 18:33:34 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7234_inosine_5_phosphate_biosyn_III +2024-07-10 18:33:34 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7237_myo__chiro__scillo_inositol_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:34 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7237_myo__chiro__scillo_inositol_deg +2024-07-10 18:33:34 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7242_D_fructuronate_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:34 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7242_D_fructuronate_deg +2024-07-10 18:33:34 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:34 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II +2024-07-10 18:33:35 WARNING::Feature name not found in dnadata so not applied to formula with effects: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site +2024-07-10 18:33:35 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:35 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn +2024-07-10 18:33:35 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:35 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn +2024-07-10 18:33:35 WARNING::Feature name not found in dnadata so not applied to formula with effects: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site +2024-07-10 18:33:35 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine + (1 | subject) + (1 | site) +2024-07-10 18:33:35 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine +2024-07-10 18:33:35 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7383_anaerobic_energy_metabolism + (1 | subject) + (1 | site) +2024-07-10 18:33:35 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7383_anaerobic_energy_metabolism +2024-07-10 18:33:35 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7388_octanoyl_acyl_carrier_protein_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:35 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7388_octanoyl_acyl_carrier_protein_biosyn +2024-07-10 18:33:35 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7400_L_arginine_biosyn_IV + (1 | subject) + (1 | site) +2024-07-10 18:33:35 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7400_L_arginine_biosyn_IV +2024-07-10 18:33:36 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7456_mannan_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:36 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7456_mannan_deg +2024-07-10 18:33:36 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III + (1 | subject) + (1 | site) +2024-07-10 18:33:36 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III +2024-07-10 18:33:36 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7560_methylerythritol_phosphate_pwy_II + (1 | subject) + (1 | site) +2024-07-10 18:33:36 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7560_methylerythritol_phosphate_pwy_II +2024-07-10 18:33:36 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7663_gondoate_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:36 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7663_gondoate_biosyn +2024-07-10 18:33:36 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_7664_oleate_biosyn_IV + (1 | subject) + (1 | site) +2024-07-10 18:33:36 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_7664_oleate_biosyn_IV +2024-07-10 18:33:36 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY_841_SP_of_purine_nt_de_novo_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:36 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY_841_SP_of_purine_nt_de_novo_biosyn_I +2024-07-10 18:33:36 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY0_1261_anhydromuropeptides_recycling + (1 | subject) + (1 | site) +2024-07-10 18:33:36 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1261_anhydromuropeptides_recycling +2024-07-10 18:33:37 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY0_1296_purine_rns_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:37 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1296_purine_rns_deg +2024-07-10 18:33:37 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY0_1297_SP_of_purine_dns_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:37 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1297_SP_of_purine_dns_deg +2024-07-10 18:33:37 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY0_1298_SP_of_pyrimidine_dns_deg + (1 | subject) + (1 | site) +2024-07-10 18:33:37 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1298_SP_of_pyrimidine_dns_deg +2024-07-10 18:33:37 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY0_1319_CDP_diacylglycerol_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:37 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1319_CDP_diacylglycerol_biosyn_II +2024-07-10 18:33:37 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY0_1479_tRNA_processing + (1 | subject) + (1 | site) +2024-07-10 18:33:37 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1479_tRNA_processing +2024-07-10 18:33:37 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY0_1586_peptidoglycan_maturation + (1 | subject) + (1 | site) +2024-07-10 18:33:37 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_1586_peptidoglycan_maturation +2024-07-10 18:33:37 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:37 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn +2024-07-10 18:33:38 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:38 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn +2024-07-10 18:33:38 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage + (1 | subject) + (1 | site) +2024-07-10 18:33:38 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage +2024-07-10 18:33:38 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY0_862_dodec_5_enoate_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:38 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY0_862_dodec_5_enoate_biosyn +2024-07-10 18:33:38 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY4FS_7_phosphatidylglycerol_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:38 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY4FS_7_phosphatidylglycerol_biosyn_I +2024-07-10 18:33:38 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY4FS_8_phosphatidylglycerol_biosyn_II + (1 | subject) + (1 | site) +2024-07-10 18:33:38 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY4FS_8_phosphatidylglycerol_biosyn_II +2024-07-10 18:33:38 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY66_399_gluconeogenesis_III + (1 | subject) + (1 | site) +2024-07-10 18:33:38 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY66_399_gluconeogenesis_III +2024-07-10 18:33:39 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY66_400_glycolysis_VI + (1 | subject) + (1 | site) +2024-07-10 18:33:39 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY66_400_glycolysis_VI +2024-07-10 18:33:39 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY66_409_SP_of_purine_nt_salvage + (1 | subject) + (1 | site) +2024-07-10 18:33:39 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY66_409_SP_of_purine_nt_salvage +2024-07-10 18:33:39 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWY66_422_D_galactose_deg_V + (1 | subject) + (1 | site) +2024-07-10 18:33:39 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWY66_422_D_galactose_deg_V +2024-07-10 18:33:39 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PWYG_321_mycolate_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:39 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PWYG_321_mycolate_biosyn +2024-07-10 18:33:39 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PYRIDNUCSYN_PWY_NAD_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:39 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PYRIDNUCSYN_PWY_NAD_biosyn_I +2024-07-10 18:33:39 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:39 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I +2024-07-10 18:33:39 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + RHAMCAT_PWY_L_rhamnose_deg_I + (1 | subject) + (1 | site) +2024-07-10 18:33:39 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, RHAMCAT_PWY_L_rhamnose_deg_I +2024-07-10 18:33:40 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + RIBOSYN2_PWY_flavin_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:40 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, RIBOSYN2_PWY_flavin_biosyn_I +2024-07-10 18:33:40 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + SALVADEHYPOX_PWY_adenosine_nt_deg_II + (1 | subject) + (1 | site) +2024-07-10 18:33:40 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, SALVADEHYPOX_PWY_adenosine_nt_deg_II +2024-07-10 18:33:40 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:40 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I +2024-07-10 18:33:40 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA + (1 | subject) + (1 | site) +2024-07-10 18:33:40 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, TCA_GLYOX_BYPASS_SP_of_glyoxylate_bypass__TCA +2024-07-10 18:33:40 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + TCA_TCA_cyc_I + (1 | subject) + (1 | site) +2024-07-10 18:33:40 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, TCA_TCA_cyc_I +2024-07-10 18:33:40 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III + (1 | subject) + (1 | site) +2024-07-10 18:33:40 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III +2024-07-10 18:33:40 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + THRESYN_PWY_SP_of_L_threonine_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:40 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, THRESYN_PWY_SP_of_L_threonine_biosyn +2024-07-10 18:33:41 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + TRNA_CHARGING_PWY_tRNA_charging + (1 | subject) + (1 | site) +2024-07-10 18:33:41 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, TRNA_CHARGING_PWY_tRNA_charging +2024-07-10 18:33:41 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I + (1 | subject) + (1 | site) +2024-07-10 18:33:41 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I +2024-07-10 18:33:41 INFO::Final formula: ~,expr,diagnosis + dysbiosisCD + dysbiosisUC + dysbiosisnonIBD + antibiotics + age + VALSYN_PWY_L_valine_biosyn + (1 | subject) + (1 | site) +2024-07-10 18:33:41 INFO::Metadata items: diagnosis, dysbiosisCD, dysbiosisUC, dysbiosisnonIBD, antibiotics, age, subject, site, VALSYN_PWY_L_valine_biosyn +2024-07-10 18:33:42 INFO::Counting total values for each feature +2024-07-10 18:33:42 INFO::Writing residuals to file demo_output/residuals.rds +2024-07-10 18:33:42 INFO::Writing fitted values to file demo_output/fitted.rds +2024-07-10 18:33:42 INFO::Writing extracted random effects to file demo_output/ranef.rds +2024-07-10 18:33:42 INFO::Writing all results to file (ordered by increasing q-values): demo_output/all_results.tsv.tmp +2024-07-10 18:33:42 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): demo_output/significant_results.tsv.tmp diff --git a/test/demo_output/ranef.rds b/test/demo_output/ranef.rds index 4728340..f55dbb0 100644 Binary files a/test/demo_output/ranef.rds and b/test/demo_output/ranef.rds differ diff --git a/test/demo_output/residuals.rds b/test/demo_output/residuals.rds index ce856a9..16123df 100644 Binary files a/test/demo_output/residuals.rds and b/test/demo_output/residuals.rds differ diff --git a/test/demo_output/significant_results.tsv b/test/demo_output/significant_results.tsv index c099b91..92624b3 100644 --- a/test/demo_output/significant_results.tsv +++ b/test/demo_output/significant_results.tsv @@ -1,268 +1,125 @@ feature metadata value coef stderr N N.not.0 pval qval -PWY_3841_folate_transformations_II diagnosis CD 3.05264527781524 0.430985950029145 803 787 3.61738181822429e-12 4.50725774550747e-09 -PWY_3841_folate_transformations_II diagnosis UC 2.90870524420221 0.431254803599096 803 787 3.34531003818098e-11 2.08412815378675e-08 -X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn diagnosis CD 3.59440522356882 0.540171132819528 803 779 5.97629898949736e-11 2.48215618030457e-08 -X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn diagnosis UC 3.51473800874412 0.538121663422411 803 779 1.29827121887383e-10 4.04411484679198e-08 -CALVIN_PWY_Calvin_Benson_Bassham_cyc age age -1.55163723974623 0.249165778277949 803 797 8.4372711832359e-10 2.10256797886239e-07 -GLYCOLYSIS_glycolysis_I age age -1.91069486459255 0.321573694621591 803 791 4.56619790930333e-09 8.51619343089558e-07 -PWY_5484_glycolysis_II age age -1.91565675199371 0.322846957546807 803 791 4.78437833196381e-09 8.51619343089558e-07 -NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I dysbiosisCD Yes -0.619799571558971 0.107065708466986 803 799 1.09385528559008e-08 1.70367960730655e-06 -CITRULBIO_PWY_L_citrulline_biosyn age age -4.50467126593872 0.837735443079392 803 688 1.0627599422361e-07 1.47133209780687e-05 -PWY_7208_SP_of_pyrimidine_nucleobases_salvage dysbiosisCD Yes -0.860041096160099 0.175456636233516 803 794 1.19612433388056e-06 0.000149037092001518 -PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn diagnosis UC 2.89165791890938 0.594287653334792 803 761 1.42750676370609e-06 0.000151717995114039 -PWY_5973_cis_vaccenate_biosyn diagnosis CD 2.54673171086829 0.523928076081053 803 787 1.46116849227004e-06 0.000151717995114039 -PWY_5030_L_histidine_deg_III diagnosis CD 5.73001198432264 1.23521594718485 803 542 4.27162072802911e-06 0.000409418417471098 -PWY0_1261_anhydromuropeptides_recycling dysbiosisCD Yes 2.53318093907947 0.559249509027303 803 273 7.2596551199336e-06 0.00064610930567409 -ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn age age -1.25178429938323 0.279807431283327 803 797 9.04872334356394e-06 0.000751647285738711 -PWY_5973_cis_vaccenate_biosyn diagnosis UC 2.32540615901983 0.52325524833308 803 787 1.03451127547391e-05 0.000758835294683263 -PANTO_PWY_phosphopantothenate_biosyn_I diagnosis UC 1.44372703155645 0.325804728296912 803 798 1.09623076278481e-05 0.000758835294683263 -PWY66_399_gluconeogenesis_III diagnosis CD 6.04806305349189 1.36377590715738 803 670 1.09505610366371e-05 0.000758835294683263 -PWY_5097_L_lysine_biosyn_VI age age -0.84092619096776 0.190821056640455 803 802 1.22315657368691e-05 0.000802133205691521 -COA_PWY_1_coenzyme_A_biosyn_II age age -0.894160839442632 0.205012594321544 803 800 1.49782851050512e-05 0.000898120457073534 -P42_PWY_incomplete_reductive_TCA_cyc diagnosis UC 4.58674887536774 1.05207317178604 803 636 1.51368616360708e-05 0.000898120457073534 -P42_PWY_incomplete_reductive_TCA_cyc diagnosis CD 4.54316714488461 1.05297074058615 803 636 1.84761377257503e-05 0.00104642125483113 -PWY_5173_SP_of_acetyl_CoA_biosyn dysbiosisCD Yes 2.45646853902419 0.569965497424357 803 335 2.10519476890312e-05 0.00109540187322775 -THRESYN_PWY_SP_of_L_threonine_biosyn age age -0.939938461696995 0.219417947657785 803 796 2.1099233513215e-05 0.00109540187322775 -PWY_5104_L_isoleucine_biosyn_IV diagnosis UC 6.61922933230559 1.584008293303 803 475 3.34223522701199e-05 0.00166577003714278 -PWY_6270_isoprene_biosyn_I diagnosis CD -4.82832342229654 1.16744663660977 803 219 4.15157261275681e-05 0.00198956133672884 -PWY_6270_isoprene_biosyn_I diagnosis UC -4.57868762026299 1.11428605970566 803 219 4.64445006001409e-05 0.00214332769436206 -PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III diagnosis CD 4.8188357527129 1.18304304102523 803 512 5.21326642576504e-05 0.00231990355946544 -PWY_7560_methylerythritol_phosphate_pwy_II diagnosis UC -4.64838840212083 1.14269111652326 803 226 5.50399498896967e-05 0.00236481991595042 -PWY_7560_methylerythritol_phosphate_pwy_II diagnosis CD -4.86209868352207 1.19838027557836 803 226 5.75396281077443e-05 0.00238981255407498 -PWY_724_SP_of_L_lysine_L_threonine__L_methionine_biosyn_II age age -0.924899860755534 0.229193123941066 803 794 6.08585257120644e-05 0.00244612009797523 -PWY_5030_L_histidine_deg_III age age -4.006571614609 1.00531111654908 803 542 7.53392934439302e-05 0.00293352373847303 -PWY_5104_L_isoleucine_biosyn_IV diagnosis CD 6.83653027492091 1.75613908708234 803 475 0.000109532961573144 0.00413569909454962 -PWY_4984_urea_cyc age age -3.24500214112581 0.836888834131598 803 665 0.000116526663527911 0.00427035949281697 -PWY_7234_inosine_5_phosphate_biosyn_III diagnosis CD 3.66387364521536 0.947495658666683 803 690 0.000121454108054917 0.00432180953694728 -PWY_4981_L_proline_biosyn_II age age -3.69088798112847 0.956435971838758 803 678 0.000125173220959615 0.00432180953694728 -PWY_5695_urate_biosyn_inosine_5_phosphate_deg diagnosis CD -1.09147586518176 0.283323129844316 803 800 0.000128336238256059 0.00432180953694728 -PWY0_1298_SP_of_pyrimidine_dns_deg dysbiosisCD Yes 1.93424214651984 0.508368320472545 803 455 0.000155727667902413 0.00510622826858965 -PWY_7219_adenosine_rnt_de_novo_biosyn diagnosis UC 0.719678808331744 0.190062998721482 803 803 0.000166653867081599 0.00532437739445314 -PWY_6700_queuosine_biosyn age age -1.69997036358819 0.454100156435154 803 780 0.000197174285195135 0.00602136073382484 -PWY_6385_peptidoglycan_biosyn_III diagnosis CD -0.94911418813798 0.253614098624703 803 797 0.000198134662991026 0.00602136073382484 -PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn diagnosis CD 2.21078962367496 0.596816559987309 803 761 0.000229719234415315 0.00681500395432101 -UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I dysbiosisCD Yes 1.71986293164518 0.465725359355046 803 503 0.000241233395689314 0.00699015839602059 -PANTO_PWY_phosphopantothenate_biosyn_I diagnosis CD 1.21536624181284 0.330379001829484 803 798 0.000253469767040968 0.00717780294847832 -PYRIDNUCSYN_PWY_NAD_biosyn_I diagnosis CD 3.22230084463242 0.877410025793593 803 707 0.000259714496816464 0.00719120584518476 -NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I age age -0.737422040505187 0.202351284619737 803 799 0.000289164529975962 0.00766593626276699 -PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn dysbiosisCD Yes -0.883407698388729 0.242395732716899 803 761 0.000288988859095824 0.00766593626276699 -PWY_2941_L_lysine_biosyn_II age age -2.92402992998588 0.834673533041073 803 454 0.000495438892156846 0.0128607679089048 -PENTOSE_P_PWY_pentose_phosphate_pwy age age -2.98538673385792 0.856939269621536 803 613 0.000527843539804927 0.0134223071550396 -PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I dysbiosisUC Yes 0.952462475525758 0.273883379309548 803 783 0.000538997350617736 0.013431813977394 -PWY_5686_UMP_biosyn dysbiosisCD Yes -0.308378461663188 0.0894424904514181 803 802 0.000601001705877024 0.0146832965788779 -PWY_7219_adenosine_rnt_de_novo_biosyn age age 0.496309066732929 0.144761083391296 803 803 0.000644623125238673 0.0152150957286576 -PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I age age -3.52023680621959 1.02736918984254 803 561 0.000650167768385146 0.0152150957286576 -PWY0_1298_SP_of_pyrimidine_dns_deg diagnosis CD -4.34099914059772 1.26837832567822 803 455 0.000660654978977823 0.0152150957286576 -PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I dysbiosisCD Yes -0.689885460946274 0.201890842276778 803 783 0.000671613374860489 0.0152150957286576 -PWY_7234_inosine_5_phosphate_biosyn_III age age -2.84541483739069 0.83729838662225 803 690 0.000719922369350866 0.0160182727180568 -PWY_5177_glutaryl_CoA_deg diagnosis CD -2.8429444817405 0.838760723129377 803 753 0.000742589547321644 0.0162048970659599 -PWY_5667_CDP_diacylglycerol_biosyn_I age age 0.635520604640089 0.1880218084069 803 801 0.000767326586590396 0.0162048970659599 -PWY0_1319_CDP_diacylglycerol_biosyn_II age age 0.635533035677839 0.188022589190229 803 801 0.000767183692095801 0.0162048970659599 -PWY_2942_L_lysine_biosyn_III diagnosis CD 0.727956187427275 0.218281944107439 803 802 0.00090081217987231 0.0187068662686816 -ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn dysbiosisCD Yes 0.488894735909724 0.147369881235348 803 797 0.000958155325550911 0.0193169295157941 -PWY_7219_adenosine_rnt_de_novo_biosyn diagnosis CD 0.629882187598775 0.189921222069065 803 803 0.000961195529678357 0.0193169295157941 -PWY_5659_GDP_mannose_biosyn diagnosis UC 1.91445741201464 0.58019152796475 803 788 0.00101986077015171 0.0199535885325577 -HISDEG_PWY_L_histidine_deg_I diagnosis CD 5.59455184339377 1.69569530739145 803 582 0.00102490342382319 0.0199535885325577 -PWY_5973_cis_vaccenate_biosyn dysbiosisnonIBD Yes 0.986871834356668 0.301215772344267 803 787 0.00110668444085557 0.0212142894354775 -VALSYN_PWY_L_valine_biosyn dysbiosisUC Yes 0.547183944636882 0.168898335223445 803 802 0.00125632160648856 0.0237178291164355 -FUCCAT_PWY_fucose_deg dysbiosisCD Yes 2.09546902585702 0.64779770989028 803 268 0.00129381579525379 0.0237393275194931 -P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate dysbiosisCD Yes 2.05647029061842 0.636325236234828 803 283 0.00129556522578293 0.0237393275194931 -PWY_6270_isoprene_biosyn_I dysbiosisCD Yes 1.50663019915754 0.46905648164226 803 219 0.00140320433998637 0.0253390232988843 -GLYCOGENSYNTH_PWY_glycogen_biosyn_I age age -2.71560097747057 0.848932240458901 803 706 0.00144572825039491 0.0257339628570294 -CALVIN_PWY_Calvin_Benson_Bassham_cyc diagnosis UC -1.02658096567356 0.321982602598031 803 797 0.00149859521360012 0.0262992906499401 -PWY_621_sucrose_deg_III dysbiosisCD Yes -1.17423717291385 0.370905925935554 803 741 0.00161719401416685 0.0276764038072357 -PWY_1042_glycolysis_IV dysbiosisCD Yes -0.30328634670591 0.0958226851730958 803 803 0.00162149075275137 0.0276764038072357 -P161_PWY_acetylene_deg age age -3.02542008914272 0.961721914890558 803 537 0.00173184582410071 0.0291605391463444 -PWY_7111_pyruvate_fermentation_to_isobutanol dysbiosisUC Yes 0.516847692315988 0.164858623937742 803 801 0.0017939863678546 0.0297588780076742 -PWY_6147_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_I diagnosis CD 3.90050307986649 1.24541980406605 803 561 0.00181514825728992 0.0297588780076742 -PWY_5083_NAD_NADH_phosphorylation__dephosphorylation dysbiosisCD Yes 1.66859427489807 0.536140430157867 803 431 0.00196822227352741 0.0312749825384791 -PWY_6969_TCA_cyc_V diagnosis CD 3.68682052667717 1.18730995309351 803 403 0.00199374548177721 0.0312749825384791 -GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg dysbiosisCD Yes 1.93160121410915 0.621362027351549 803 300 0.00200540945835368 0.0312749825384791 -COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn diagnosis UC -1.59196484491283 0.513304459844149 803 773 0.00200802456105805 0.0312749825384791 -PWY_5030_L_histidine_deg_III antibiotics Yes -1.331164557424 0.430282314814207 803 542 0.00206527500779591 0.0314803134623406 -PWY_5676_acetyl_CoA_fermentation_to_butanoate_II diagnosis CD 5.17245246123787 1.67132410421765 803 459 0.00207173812512996 0.0314803134623406 -THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III age age -1.99009547946184 0.644699066724266 803 682 0.00210743241141135 0.031636876923115 -PWY_6163_chorismate_biosyn_from_3_dehydroquinate diagnosis UC -1.65720591123994 0.540044875876204 803 787 0.00223829578787553 0.0328550108452482 -PWY_5083_NAD_NADH_phosphorylation__dephosphorylation age age -3.33450800598892 1.08590875920207 803 431 0.00225741382250582 0.0328550108452482 -PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage dysbiosisUC Yes -1.28939740805081 0.420704191342603 803 754 0.00226768132639755 0.0328550108452482 -PWYG_321_mycolate_biosyn dysbiosisUC Yes -2.4500585049096 0.803259092992068 803 484 0.00239301766514847 0.0342724139169539 -GLUCONEO_PWY_gluconeogenesis_I diagnosis CD 5.03529285759158 1.65238995794544 803 457 0.00244482077666952 0.034616439633298 -PWY_6609_adenine__adenosine_salvage_III diagnosis CD -1.32741692017642 0.436928295248414 803 792 0.00247473373978491 0.0346462723569887 -PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage age age -1.65871634778509 0.550730514135276 803 754 0.00269713331202983 0.0373403122976574 -GALACTUROCAT_PWY_D_galacturonate_deg_I diagnosis CD -1.91063943444158 0.635655652193639 803 776 0.00274924420077012 0.0376423687564666 -PWY66_399_gluconeogenesis_III diagnosis UC 3.86295109936287 1.28614877824689 803 670 0.00277937233193814 0.0376423687564666 -RIBOSYN2_PWY_flavin_biosyn_I dysbiosisCD Yes 1.39207200954757 0.464822971301858 803 478 0.00285981798828419 0.0382991070699835 -NONOXIPENT_PWY_pentose_phosphate_pwy dysbiosisCD Yes -0.436121647516736 0.145839491369122 803 800 0.00288933873561673 0.0382991070699835 -HISTSYN_PWY_L_histidine_biosyn diagnosis UC 2.31048840137836 0.774997367996051 803 698 0.00297592748253542 0.038625058783741 -PWY_1042_glycolysis_IV diagnosis CD -0.672640853289993 0.225597997873084 803 803 0.00297284328891875 0.038625058783741 -PWY_5690_TCA_cyc_II diagnosis CD -3.93724739511105 1.33199377104953 803 363 0.00323715268691119 0.0413484474980901 -PWY_4984_urea_cyc dysbiosisUC Yes -1.72826436516925 0.585053970736899 803 665 0.00325246119535355 0.0413484474980901 -CALVIN_PWY_Calvin_Benson_Bassham_cyc diagnosis CD -0.948872334037213 0.321601978015978 803 797 0.0032853100339574 0.0413484474980901 -PWY_7234_inosine_5_phosphate_biosyn_III diagnosis UC 2.76953007255583 0.941779868291383 803 690 0.00339214110702896 0.0414905711081256 -PWY_7560_methylerythritol_phosphate_pwy_II dysbiosisCD Yes 1.41291689083353 0.480017212880122 803 226 0.00339522687459724 0.0414905711081256 -PWY_6163_chorismate_biosyn_from_3_dehydroquinate age age -1.22975753689499 0.418417864697069 803 787 0.00340684830750579 0.0414905711081256 -PWY0_1297_SP_of_purine_dns_deg diagnosis UC -3.34235158187466 1.13801354699121 803 610 0.0034297984142351 0.0414905711081256 -PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I age age -1.66654854209283 0.571171438662267 803 765 0.00364622324545134 0.0436845592676189 -PWY_5097_L_lysine_biosyn_VI dysbiosisCD Yes -0.288387684758922 0.0991677046790489 803 802 0.00375833922680458 0.0445652598794044 -PWY_5154_L_arginine_biosyn_III diagnosis CD 3.48441699173201 1.19919166865325 803 475 0.00379126608925912 0.0445652598794044 -PWY_5695_urate_biosyn_inosine_5_phosphate_deg dysbiosisUC Yes -0.445826669632914 0.154545167831939 803 800 0.00404441351487615 0.0470966284068755 -X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn dysbiosisCD Yes -0.612828784080733 0.212695401192953 803 779 0.00408922706723582 0.047177564127554 -GLYOXYLATE_BYPASS_glyoxylate_cyc diagnosis CD 5.96772764671664 2.09462424733514 803 255 0.0046305846462502 0.0522655909084256 -TCA_TCA_cyc_I dysbiosisCD Yes 1.4143995365867 0.497717761871118 803 412 0.00464278312975318 0.0522655909084256 -PWY0_1586_peptidoglycan_maturation diagnosis UC -2.4571382936522 0.865316239309403 803 773 0.00465608394128029 0.0522655909084256 -ARGININE_SYN4_PWY_L_ornithine_de_novo_biosyn age age -1.20089070796135 0.424030923830307 803 732 0.00477647493826893 0.0531382836882418 -HISDEG_PWY_L_histidine_deg_I diagnosis UC 5.01586071599512 1.77553760460812 803 582 0.00488046275144427 0.0536703585190257 -GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisCD Yes 1.25549995101894 0.44484025766632 803 706 0.00491045013737474 0.0536703585190257 -PWYG_321_mycolate_biosyn dysbiosisCD Yes -1.74303573870379 0.618895669964247 803 484 0.00502436702387348 0.0544379244499683 -ARO_PWY_chorismate_biosyn_I diagnosis UC -1.53359274374935 0.545890878522736 803 775 0.00511106611896567 0.0548998998640623 -FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation dysbiosisUC Yes -2.06308105711701 0.740024275964381 803 539 0.00547680924019979 0.0578042272302705 -PWY0_1261_anhydromuropeptides_recycling dysbiosisnonIBD Yes 2.51240258107829 0.901285746833122 803 273 0.00549503689381399 0.0578042272302705 -HISTSYN_PWY_L_histidine_biosyn age age 1.68776731521395 0.606209401778404 803 698 0.00552062844334044 0.0578042272302705 -DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I dysbiosisCD Yes -0.459428084188009 0.166621063765707 803 790 0.00598860606704485 0.062181692996149 -NAGLIPASYN_PWY_lipid_IVA_biosyn diagnosis CD 3.07120780530194 1.11942012019399 803 601 0.0062535693501001 0.0640221986433617 -PWY_7539_6_hydroxymethyl_dihydropterin_diphosphate_biosyn_III age age -2.83976958514902 1.03550843617897 803 512 0.0062686261914046 0.0640221986433617 -PEPTIDOGLYCANSYN_PWY_peptidoglycan_biosyn_I diagnosis CD -0.475714544997513 0.174487379785264 803 799 0.00657329031693522 0.0665879653244007 -CALVIN_PWY_Calvin_Benson_Bassham_cyc dysbiosisCD Yes -0.370700414722683 0.136374777759911 803 797 0.0067349606716076 0.0676754919098635 -PWY_7221_guanosine_rnt_de_novo_biosyn diagnosis UC 0.533682479302856 0.197650540597453 803 802 0.00710833936697873 0.070855926810044 -PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I diagnosis CD 1.70476936987922 0.636224984427994 803 762 0.0075563436847742 0.0742598318719255 -PWY66_409_SP_of_purine_nt_salvage dysbiosisCD Yes 1.21581005566826 0.453713389198176 803 290 0.00756901978148839 0.0742598318719255 -PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I diagnosis CD -0.480286445268109 0.179680743986461 803 799 0.00770288944946652 0.0749828144846506 -PWY_6609_adenine__adenosine_salvage_III diagnosis UC -1.16333420477748 0.43675497077132 803 792 0.00791937381167113 0.0764925563514901 -PWY_841_SP_of_purine_nt_de_novo_biosyn_I diagnosis UC 3.04836132220398 1.15421852323589 803 651 0.00846180195156154 0.0811031171665052 -PWY_7221_guanosine_rnt_de_novo_biosyn dysbiosisUC Yes 0.284590745874492 0.108229752445835 803 802 0.00874952781027188 0.0828792798683633 -PWY_7456_mannan_deg age age 1.56670407383874 0.595162697794659 803 210 0.00878014842907219 0.0828792798683633 -PWY_7221_guanosine_rnt_de_novo_biosyn antibiotics Yes 0.180991354912172 0.0690526360897559 803 802 0.00896685388047396 0.0835273237767145 -NONOXIPENT_PWY_pentose_phosphate_pwy age age 0.704279354653536 0.268762893956953 803 800 0.00898287430664506 0.0835273237767145 -PWY_5690_TCA_cyc_II dysbiosisCD Yes 1.4775866614899 0.566843883870559 803 363 0.00936417036967852 0.0864278243008847 -PWY_7219_adenosine_rnt_de_novo_biosyn antibiotics Yes 0.170739858277942 0.0655946178140567 803 803 0.00944939842739257 0.0865436545391461 -PYRIDNUCSYN_PWY_NAD_biosyn_I diagnosis UC 2.28596207530267 0.879585922482971 803 707 0.00956199087352787 0.0865436545391461 -TRNA_CHARGING_PWY_tRNA_charging diagnosis UC 2.45677359856966 0.945614885417257 803 703 0.00958509175473689 0.0865436545391461 -PWY_5686_UMP_biosyn diagnosis UC 0.568445257469621 0.219298787170743 803 802 0.00974956192774976 0.087395353683282 -PWY_7456_mannan_deg dysbiosisUC Yes 1.6789343055371 0.649387743993936 803 210 0.010050616054872 0.0891950416322004 -PWY_5690_TCA_cyc_II diagnosis UC -3.41360337953948 1.32278781013086 803 363 0.0100934998957787 0.0891950416322004 -PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II age age -0.422387316594344 0.164685388587168 803 798 0.010542761779585 0.0925090223757951 -PWY_5676_acetyl_CoA_fermentation_to_butanoate_II age age -3.48203436364371 1.35975630584861 803 459 0.0107155330445155 0.0931195491307281 -PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II dysbiosisCD Yes -0.220541178863587 0.0862655546178387 803 798 0.0107942965501293 0.0931195491307281 -PWY_7664_oleate_biosyn_IV dysbiosisUC Yes -1.9532148364336 0.765372181949336 803 531 0.0109625901451874 0.0931195491307281 -PWY_7221_guanosine_rnt_de_novo_biosyn dysbiosisCD Yes -0.202799190104736 0.079638206663245 803 802 0.01110603727809 0.0931195491307281 -PWY_6700_queuosine_biosyn diagnosis CD 1.61710211776164 0.635275383683058 803 780 0.0111373500321734 0.0931195491307281 -P161_PWY_acetylene_deg dysbiosisCD Yes 1.23799452886457 0.486459453840077 803 537 0.0111610355056048 0.0931195491307281 -PWY_5484_glycolysis_II dysbiosisUC Yes -0.584613800709197 0.22975394890982 803 791 0.0111694192587447 0.0931195491307281 -PWY_5723_Rubisco_shunt age age -3.19955083425621 1.25483001882651 803 212 0.0112506810877701 0.0931195491307281 -PWY_841_SP_of_purine_nt_de_novo_biosyn_I dysbiosisnonIBD Yes 1.80358551567498 0.70980928036555 803 651 0.0112849533858266 0.0931195491307281 -PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn antibiotics Yes -0.891212704313458 0.352882966737514 803 469 0.0117896909053057 0.0966444399211244 -CITRULBIO_PWY_L_citrulline_biosyn dysbiosisUC Yes -1.47150860291564 0.585496500536171 803 688 0.0122071998375724 0.0994128823373543 -PWY_5188_tetrapyrrole_biosyn_I age age -1.73170726638829 0.690130705438622 803 731 0.0123373869021563 0.0998206758447192 -PANTOSYN_PWY_pantothenate__coenzyme_A_biosyn_I diagnosis UC 1.58112186881966 0.635664214543089 803 762 0.0131148475814906 0.104880210182633 -PWY_6282_palmitoleate_biosyn_I dysbiosisUC Yes -1.92380604648686 0.773313313788378 803 531 0.0131310696536844 0.104880210182633 -PWY_5723_Rubisco_shunt dysbiosisCD Yes 1.70353973525433 0.687497214264005 803 212 0.0137385519065928 0.109033348252322 -PWY_5659_GDP_mannose_biosyn diagnosis CD 1.46226169434878 0.593058121839938 803 788 0.0139301720550687 0.109271574345925 -PWY_7234_inosine_5_phosphate_biosyn_III dysbiosisnonIBD Yes 1.46602924477965 0.594625460636894 803 690 0.0139439649446245 0.109271574345925 -PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I age age -0.9414150887106 0.3831051518462 803 792 0.0142528422238434 0.11099400881818 -PWY_7388_octanoyl_acyl_carrier_protein_biosyn dysbiosisUC Yes -1.86374293411196 0.759223004868045 803 535 0.0143842888335482 0.111321887494417 -PWY_5173_SP_of_acetyl_CoA_biosyn dysbiosisnonIBD Yes 2.32650939579295 0.956119707764535 803 335 0.0154433328631262 0.117334247580971 -FASYN_ELONG_PWY_fatty_acid_elongation__saturated dysbiosisUC Yes -1.84544984320372 0.759887272908051 803 532 0.0154561944772198 0.117334247580971 -PWY_7199_pyrimidine_dns_salvage dysbiosisUC Yes -1.50373591511822 0.619729706983198 803 694 0.0155142651541349 0.117334247580971 -PWY_5173_SP_of_acetyl_CoA_biosyn antibiotics Yes 1.62907732469542 0.670469296435198 803 335 0.0155918834237137 0.117334247580971 -PWY0_1296_purine_rns_deg age age -1.04055533854071 0.429332410228001 803 793 0.0156320105123926 0.117334247580971 -PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn antibiotics Yes -0.504217808838281 0.209315708065049 803 761 0.0162742068270342 0.121423123990926 -PWY_7219_adenosine_rnt_de_novo_biosyn dysbiosisUC Yes 0.245427644862995 0.102677510112845 803 803 0.0171142853593283 0.126930949748352 -PWY_5989_stearate_biosyn_II age age -2.44389560443087 1.0258348283489 803 575 0.0174887604580398 0.12793288991053 -PWY0_862_dodec_5_enoate_biosyn dysbiosisUC Yes -1.81432081761082 0.761760366980329 803 546 0.0175451452374195 0.12793288991053 -PANTO_PWY_phosphopantothenate_biosyn_I age age -0.59537691895859 0.250259451532095 803 798 0.0176403734573441 0.12793288991053 -PWY_6901_SP_of_glucose__xylose_deg age age -1.8699327759532 0.785907451070399 803 436 0.0176600779009721 0.12793288991053 -PWY_7220_adenosine_dnt_de_novo_biosyn_II age age -1.18416390385024 0.501238037103492 803 783 0.0184415249680763 0.131877196371536 -PWY_7222_guanosine_dnt_de_novo_biosyn_II age age -1.18416390385024 0.501238037103492 803 783 0.0184415249680763 0.131877196371536 -PWY66_400_glycolysis_VI dysbiosisCD Yes -0.440080553119025 0.186405010504921 803 789 0.0185220781420696 0.131877196371536 -PWY_1042_glycolysis_IV dysbiosisnonIBD Yes -0.327024020464739 0.139637398923078 803 803 0.0194787090298499 0.137853776595464 -PWY_7208_SP_of_pyrimidine_nucleobases_salvage dysbiosisUC Yes 0.552107369551107 0.235948814510189 803 794 0.0195827595966269 0.137853776595464 -FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation age age -2.57208833614667 1.10517084832061 803 539 0.0202855516302983 0.141297942859854 -PWY_7242_D_fructuronate_deg diagnosis CD -1.3980085157593 0.60093524876142 803 773 0.0202988216468008 0.141297942859854 -ANAGLYCOLYSIS_PWY_glycolysis_III diagnosis UC -0.541959792072256 0.234422333017812 803 801 0.021089974974617 0.145396731239547 -PWY_6126_SP_of_adenosine_nt_de_novo_biosyn_II age age -1.08953029197237 0.471387347039083 803 783 0.0211210339922616 0.145396731239547 -PWY_2942_L_lysine_biosyn_III dysbiosisCD Yes -0.200059349172418 0.087034140130862 803 802 0.0218365928821871 0.149496674347281 -PWY_2941_L_lysine_biosyn_II diagnosis UC -2.29737669310202 1.00330355750649 803 454 0.0223935537003995 0.152434718646547 -ANAGLYCOLYSIS_PWY_glycolysis_III dysbiosisCD Yes -0.221580406806395 0.0968864841344416 803 801 0.0225104239413842 0.152434718646547 -DTDPRHAMSYN_PWY_dTDP_L_rhamnose_biosyn_I diagnosis CD -0.897762149648618 0.39326219868104 803 790 0.0227553404557966 0.153260293015798 -PWY_5154_L_arginine_biosyn_III diagnosis UC 2.73027451494726 1.1975349112771 803 475 0.0229400100927613 0.153673400943982 -PWY_5177_glutaryl_CoA_deg dysbiosisCD Yes -0.835470560887026 0.367066206454403 803 753 0.0231654099316293 0.154353480079198 -ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn diagnosis UC -0.830122867508703 0.366039122282495 803 797 0.0236600791848168 0.156005640308873 -P42_PWY_incomplete_reductive_TCA_cyc dysbiosisUC Yes -1.34020526052796 0.590964697829162 803 636 0.0236671684976644 0.156005640308873 -ANAEROFRUCAT_PWY_homolactic_fermentation age age -1.0978083576094 0.484890771425391 803 770 0.0238958535559513 0.156005640308873 -PWY_6901_SP_of_glucose__xylose_deg diagnosis UC -2.19719744446751 0.970348583523281 803 436 0.0239141872383585 0.156005640308873 -PWY_5989_stearate_biosyn_II dysbiosisUC Yes -1.64350194370299 0.729073224200398 803 575 0.0245130935721857 0.158528459025866 -ANAEROFRUCAT_PWY_homolactic_fermentation diagnosis CD -1.4276553251504 0.633753866099814 803 770 0.0246059423943171 0.158528459025866 -PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn diagnosis CD 3.40743008667169 1.51330251771969 803 504 0.0246826011645409 0.158528459025866 -PWY_621_sucrose_deg_III age age -1.60351611835591 0.713762431028364 803 741 0.024996426548692 0.159720756306001 -PWY_6609_adenine__adenosine_salvage_III dysbiosisUC Yes -0.543978870471204 0.242360014470234 803 792 0.0251292824945726 0.159750438715497 -PWY_5667_CDP_diacylglycerol_biosyn_I dysbiosisUC Yes -0.29541637601192 0.132381561270503 803 801 0.0259785560048291 0.163512820559052 -PWY0_1319_CDP_diacylglycerol_biosyn_II dysbiosisUC Yes -0.2954077766099 0.132382187345371 803 801 0.0259835782268799 0.163512820559052 -PWY_4041_beta_glutamyl_cyc dysbiosisCD Yes 1.5122050707407 0.67896155075936 803 247 0.0266336553822621 0.166508440829747 -PWY_6703_preQ0_biosyn diagnosis CD -1.67826013908949 0.755823999798905 803 771 0.0267268765376801 0.166508440829747 -CITRULBIO_PWY_L_citrulline_biosyn diagnosis CD 2.43837586632766 1.10253649936378 803 688 0.0273476080703596 0.168874359266683 -PWY_7208_SP_of_pyrimidine_nucleobases_salvage diagnosis UC 0.958692238319397 0.433603521845272 803 794 0.0273777051138603 0.168874359266683 -PWY_7388_octanoyl_acyl_carrier_protein_biosyn age age -2.4625501545818 1.11846016008044 803 535 0.0280711454526309 0.171628196010118 -PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II diagnosis CD -0.474082398939629 0.215419735004758 803 798 0.0280996404382537 0.171628196010118 -PWY_7187_pyrimidine_dnt_de_novo_biosyn_II dysbiosisCD Yes 0.8790175211288 0.399952756541716 803 647 0.0283102359491576 0.172070995086099 -PWY_6353_purine_nt_deg_II dysbiosisnonIBD Yes -1.72695178629372 0.786423730958322 803 432 0.0284554465619995 0.172114011729376 -PWY_5101_L_isoleucine_biosyn_II dysbiosisnonIBD Yes 1.47384304615579 0.673903700627913 803 574 0.0291198395439606 0.175281739477173 -COMPLETE_ARO_PWY_SP_of_aromatic_amino_acid_biosyn diagnosis CD -1.12215502434144 0.514115139342888 803 773 0.0294096848705575 0.175659409196463 -GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg diagnosis CD -1.65634684079506 0.759115024723411 803 755 0.0294645397448321 0.175659409196463 -PWY_6527_stachyose_deg dysbiosisCD Yes -0.650819792382779 0.30093790343197 803 766 0.0309264067619489 0.183496680120897 -PWY0_1298_SP_of_pyrimidine_dns_deg diagnosis UC -2.58660450589624 1.20375023816246 803 455 0.0320309744958461 0.188067234386109 -HISDEG_PWY_L_histidine_deg_I age age -2.93467537772331 1.36864781162428 803 582 0.0324038054606549 0.188067234386109 -GLYCOLYSIS_glycolysis_I dysbiosisUC Yes -0.490006142600401 0.228616972647953 803 791 0.0324499055308832 0.188067234386109 -PWY_7664_oleate_biosyn_IV age age -2.41113643971288 1.1255135952566 803 531 0.0325823558317502 0.188067234386109 -PWY_5690_TCA_cyc_II antibiotics Yes -1.06909335800202 0.49915635827539 803 363 0.0326023456078648 0.188067234386109 -PWY_6282_palmitoleate_biosyn_I age age -2.43622081611288 1.13731043733733 803 531 0.032595675560779 0.188067234386109 -PWY_7237_myo__chiro__scillo_inositol_deg dysbiosisnonIBD Yes 2.12164997231393 0.995001623363449 803 441 0.0333645778667636 0.191577253557546 -PWY_5723_Rubisco_shunt diagnosis CD 3.40280891302731 1.59811772630159 803 212 0.0340055318979734 0.193771802435918 -PWY_6123_inosine_5_phosphate_biosyn_I dysbiosisCD Yes -0.317445467097846 0.149471142774951 803 794 0.0340578047620112 0.193771802435918 -PWY_6609_adenine__adenosine_salvage_III dysbiosisCD Yes -0.380928184243369 0.17962396330186 803 792 0.034318406797813 0.194366976682159 -COA_PWY_1_coenzyme_A_biosyn_II dysbiosisCD Yes -0.228571834043813 0.107931687239718 803 800 0.0345687754448608 0.194899068797722 -ARGSYNBSUB_PWY_L_arginine_biosyn_II diagnosis UC 3.50795234478356 1.65827417321762 803 428 0.0347875895790105 0.195249264033545 -PWY_7237_myo__chiro__scillo_inositol_deg diagnosis UC 3.2231891561406 1.52548686925485 803 441 0.0349996189547771 0.195558409047768 -PWY_5686_UMP_biosyn diagnosis CD 0.464676305374308 0.220277620313914 803 802 0.0352759812018213 0.195710807897112 -PWYG_321_mycolate_biosyn antibiotics Yes -1.08912751408391 0.516314899615009 803 484 0.0353410367390451 0.195710807897112 -PWY_5913_TCA_cyc_VI dysbiosisUC Yes 2.20868062493257 1.05076607978298 803 146 0.0362931386534313 0.20009402992113 -FASYN_ELONG_PWY_fatty_acid_elongation__saturated age age -2.33381008533388 1.11629440951929 803 532 0.0369851497956642 0.202434826336315 -PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I diagnosis UC 1.08527747143909 0.51939232238205 803 792 0.0370426487999036 0.202434826336315 -COA_PWY_1_coenzyme_A_biosyn_II diagnosis UC -0.552008643319785 0.265292571185297 803 800 0.0378403186291681 0.20589099131853 -PWY_3841_folate_transformations_II dysbiosisnonIBD Yes 0.531302158177561 0.256106951658205 803 787 0.0384157502436009 0.208113151319681 -ANAGLYCOLYSIS_PWY_glycolysis_III age age -0.370037928738964 0.179099764935781 803 801 0.0392081416900967 0.21148634002537 -PWY66_409_SP_of_purine_nt_salvage dysbiosisUC Yes 1.37067094630079 0.667108172255097 803 290 0.0403407637981788 0.215100679934508 -ANAGLYCOLYSIS_PWY_glycolysis_III diagnosis CD -0.480787565148031 0.234093781516703 803 801 0.0403854905492756 0.215100679934508 -GLCMANNANAUT_PWY_SP_of_N_acetylglucosamine_N_acetylmannosamine__N_acetylneuraminate_deg dysbiosisUC Yes -0.842349169041311 0.410158702730016 803 757 0.0403961148512639 0.215100679934508 -GLYOXYLATE_BYPASS_glyoxylate_cyc dysbiosisnonIBD Yes 2.88591178616923 1.40535040393256 803 255 0.040726745761618 0.215385553400785 -GALACT_GLUCUROCAT_PWY_SP_of_hexuronide__hexuronate_deg diagnosis CD -1.621347248222 0.791719008218697 803 745 0.0409673674527648 0.215385553400785 -GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisnonIBD Yes 1.38002326821618 0.67388505032519 803 706 0.0409681991621076 0.215385553400785 -PWY_5723_Rubisco_shunt dysbiosisnonIBD Yes 2.02279896859514 0.991324488518343 803 212 0.0421313074030373 0.220569785815901 -PWY_4041_beta_glutamyl_cyc dysbiosisnonIBD Yes 2.222095319289 1.09049964402993 803 247 0.04241141150372 0.221107191354122 -PWY66_400_glycolysis_VI antibiotics Yes -0.325184006564041 0.160905849143336 803 789 0.043688565137571 0.226400537765929 -SER_GLYSYN_PWY_SP_of_L_serine__glycine_biosyn_I age age -1.20268390521143 0.595400682117846 803 767 0.0437901521682093 0.226400537765929 -P42_PWY_incomplete_reductive_TCA_cyc age age -1.64624342565721 0.815917638211378 803 636 0.0440372483575055 0.226737237410958 -GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisUC Yes 1.23248893470933 0.614463165033732 803 706 0.0452848518722276 0.231474943568693 -GLYOXYLATE_BYPASS_glyoxylate_cyc age age -3.26169519803585 1.62402619056093 803 255 0.0453289616619271 0.231474943568693 -PWY0_1296_purine_rns_deg diagnosis UC -1.11463610845491 0.558594203215076 803 793 0.0464052805082405 0.234835308972683 -PWY_4242_pantothenate__coenzyme_A_biosyn_III diagnosis CD 1.98558449756849 0.995683852413033 803 725 0.0465408278094516 0.234835308972683 -THRESYN_PWY_SP_of_L_threonine_biosyn dysbiosisCD Yes 0.23288191867416 0.116786305282758 803 796 0.0465524248124019 0.234835308972683 -PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I dysbiosisCD Yes -0.598543905947332 0.301090594572384 803 765 0.0472364596679049 0.237325115912135 -PWY_7383_anaerobic_energy_metabolism diagnosis CD 2.42771434493264 1.22381325073863 803 698 0.0477338607198607 0.237567805483478 -PYRIDOXSYN_PWY_pyridoxal_5_phosphate_biosyn_I dysbiosisUC Yes -0.862193753797441 0.434715082489302 803 765 0.0477451035527287 0.237567805483478 -PWY_6901_SP_of_glucose__xylose_deg dysbiosisCD Yes 0.812338667337047 0.409702315722133 803 436 0.0478567569633652 0.237567805483478 -PWY_6700_queuosine_biosyn diagnosis UC 1.23227985590047 0.623231143512816 803 780 0.0484285264746147 0.239452158680039 -P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate dysbiosisUC Yes 1.75120320889801 0.88676367852566 803 283 0.0487326681982915 0.240003575395538 -PWY66_400_glycolysis_VI diagnosis UC 0.906460041922668 0.459826450250736 803 789 0.0491071268098653 0.240895590571229 -PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn diagnosis UC -2.93224242858277 1.4927105175364 803 504 0.0499189911645435 0.243306835372029 -PWY_6121_5_aminoimidazole_rnt_biosyn_I diagnosis UC 0.589531603311326 0.30022284416941 803 799 0.0499892053412837 0.243306835372029 -PWY66_409_SP_of_purine_nt_salvage diagnosis UC -2.11713981524635 1.07945546258629 803 290 0.0503003505032321 0.243868625396993 -PWY_7242_D_fructuronate_deg dysbiosisUC Yes 0.655252129434378 0.334960663781829 803 773 0.0508609833743255 0.244290439161783 -PWY_4981_L_proline_biosyn_II dysbiosisnonIBD Yes 1.53031871286915 0.782574386641866 803 678 0.0509516668633515 0.244290439161783 -PWY_5188_tetrapyrrole_biosyn_I dysbiosisCD Yes 0.713044797873293 0.364946236413597 803 731 0.0511427303653103 0.244290439161783 -P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate age age -2.42632408421033 1.24287730948993 803 283 0.0513676525364263 0.244290439161783 -PWY_6125_SP_of_guanosine_nt_de_novo_biosyn_II age age -0.959536927258179 0.491559171971616 803 769 0.0513561822889642 0.244290439161783 -PWY_6151_S_adenosyl_L_methionine_cyc_I diagnosis CD -0.7595556305137 0.389738295552138 803 791 0.0517310470026779 0.245083211275044 -PENTOSE_P_PWY_pentose_phosphate_pwy dysbiosisUC Yes -1.19120413784332 0.613443254340229 803 613 0.0525924200814272 0.248123996175261 -RIBOSYN2_PWY_flavin_biosyn_I age age -1.6650337470461 0.857974538154669 803 478 0.0527711548847866 0.248123996175261 -PWY_6507_4_deoxy_L_threo_hex_4_enopyranuronate_deg diagnosis CD -1.59924783167854 0.825485293988914 803 757 0.0531298001322517 0.248346722318496 -PWY_7196_SP_of_pyrimidine_rns_salvage dysbiosisnonIBD Yes -1.37929616490298 0.712125565706007 803 411 0.0532171547825349 0.248346722318496 +NONMEVIPP_PWY_methylerythritol_phosphate_pwy_I dysbiosisCD Yes -0.618633313279904 0.0924319217817194 803 799 4.57663979099407e-11 5.70249317957861e-08 +PWY0_1261_anhydromuropeptides_recycling dysbiosisCD Yes 2.96249879369237 0.471855942629623 803 273 6.8599471822699e-10 4.27374709455415e-07 +PWY_5173_SP_of_acetyl_CoA_biosyn dysbiosisCD Yes 2.94208859054454 0.480266927945764 803 335 2.02929351664638e-09 8.42833240580463e-07 +PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn dysbiosisCD Yes -1.1470771577878 0.194875749038429 803 761 6.92706938086865e-09 2.15778211214058e-06 +PWY_7208_SP_of_pyrimidine_nucleobases_salvage dysbiosisCD Yes -0.822329491615039 0.145579340919081 803 794 2.49226234696658e-08 6.21071776864072e-06 +PWY_5097_L_lysine_biosyn_VI dysbiosisCD Yes -0.439251369576312 0.080948197644148 803 802 8.56790491098012e-08 1.7792682531802e-05 +ASPASN_PWY_SP_of_L_aspartate__L_asparagine_biosyn dysbiosisCD Yes 0.64130934427015 0.124271967866938 803 797 3.31993481305146e-07 5.9094839672316e-05 +PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I dysbiosisCD Yes -0.817284584546322 0.162578410138359 803 783 6.87257633307663e-07 0.000107040376387669 +UDPNAGSYN_PWY_UDP_N_acetyl_D_glucosamine_biosyn_I dysbiosisCD Yes 1.76264917945981 0.366609958119706 803 503 2.03910197340086e-06 0.000282302339873052 +PWY_5723_Rubisco_shunt dysbiosisCD Yes 2.41652915791416 0.542113958383048 803 212 1.12598100325778e-05 0.00140297233005919 +PWYG_321_mycolate_biosyn dysbiosisCD Yes -2.13446387947385 0.488709827480479 803 484 1.52720989928251e-05 0.00172991230409637 +GLUCOSE1PMETAB_PWY_glucose__glucose_1_phosphate_deg dysbiosisCD Yes 2.16700389549834 0.499847930829683 803 300 1.81801024440753e-05 0.00188770063710982 +PWY_5083_NAD_NADH_phosphorylation__dephosphorylation dysbiosisCD Yes 1.96850253625639 0.457763684079564 803 431 2.03368666625553e-05 0.00194921045088799 +FUCCAT_PWY_fucose_deg dysbiosisCD Yes 2.10484912666633 0.503707644195467 803 268 3.47541901155345e-05 0.00309312292028257 +PWY0_1298_SP_of_pyrimidine_dns_deg dysbiosisCD Yes 1.63963992674933 0.408009987284711 803 455 6.69756521434233e-05 0.00556344417138036 +PWY_6386_UDP_N_acetylmuramoyl_pentapeptide_biosyn_II dysbiosisCD Yes -0.286895010072458 0.0741949316042205 803 798 0.00012097600780991 0.00942100660819674 +CITRULBIO_PWY_L_citrulline_biosyn dysbiosisCD Yes -1.443146698241 0.379536791072413 803 688 0.000157151459049691 0.011518277527995 +PWY_7456_mannan_deg dysbiosisUC Yes 2.2945779392424 0.607182533870461 803 210 0.000175600521071577 0.0121554582919547 +PWY_5686_UMP_biosyn dysbiosisCD Yes -0.290623736376054 0.0776565557664913 803 802 0.000197561911040696 0.0129559021661425 +PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I age age -0.535992327359665 0.138821714950822 803 557 0.000214757065684506 0.0130080685528097 +PWY_5484_glycolysis_II dysbiosisUC Yes -0.792099678122814 0.213291248235628 803 791 0.000219237110440613 0.0130080685528097 +PWY_4041_beta_glutamyl_cyc dysbiosisCD Yes 2.00199208424061 0.539069441732202 803 247 0.000238901979685604 0.013530539394921 +PWY_7197_pyrimidine_dnt_phosphorylation dysbiosisCD Yes -0.942711709954558 0.25761491339299 803 751 0.000275589359856416 0.0149297540165693 +PWY_7221_guanosine_rnt_de_novo_biosyn antibiotics Yes 0.234847899249754 0.0653759723735983 803 802 0.000348879672058809 0.0181126696410532 +PWY_6609_adenine__adenosine_salvage_III dysbiosisCD Yes -0.504989595255633 0.143289851300085 803 792 0.000463653330920992 0.0231084820131022 +PWY66_409_SP_of_purine_nt_salvage dysbiosisCD Yes 1.24431301989943 0.355727482979021 803 290 0.000508576718694727 0.0236799336010274 +PWY_621_sucrose_deg_III dysbiosisCD Yes -1.06273392924442 0.304176170228449 803 741 0.000513128577229326 0.0236799336010274 +VALSYN_PWY_L_valine_biosyn dysbiosisUC Yes 0.545762265356123 0.160524185932954 803 802 0.00070950913871425 0.0312265203685879 +X1CMET2_PWY_N10_formyl_tetrahydrofolate_biosyn dysbiosisCD Yes -0.597692711349317 0.176976685545883 803 779 0.000776903797292316 0.0312265203685879 +FASYN_ELONG_PWY_fatty_acid_elongation__saturated age age -0.558052848474461 0.160360213636686 803 532 0.000774905278396707 0.0312265203685879 +TCA_TCA_cyc_I dysbiosisCD Yes 1.26856596249795 0.37470513520993 803 412 0.000773718903672318 0.0312265203685879 +P461_PWY_hexitol_fermentation_to_lactate_formate_ethanol__acetate dysbiosisCD Yes 1.73387526324221 0.515878036656341 803 283 0.000830753929478712 0.0323474811290774 +PWY_7664_oleate_biosyn_IV age age -0.563448388427534 0.164461727011425 803 531 0.000921670014420038 0.0348000253929505 +PWY_6270_isoprene_biosyn_I dysbiosisCD Yes 1.33226079885382 0.40555992622629 803 219 0.00108243664687847 0.0386167812256071 +PWY_6282_palmitoleate_biosyn_I age age -0.558469124979553 0.165450375323472 803 531 0.00108474104566312 0.0386167812256071 +PWY_7111_pyruvate_fermentation_to_isobutanol dysbiosisUC Yes 0.512528705095113 0.156845257116594 803 801 0.00113314267784267 0.0392193271275546 +GLYCOLYSIS_glycolysis_I dysbiosisUC Yes -0.691763452770188 0.212553893016718 803 791 0.00118593811220563 0.0399372672380599 +PWY66_400_glycolysis_VI dysbiosisCD Yes -0.446091676058877 0.137743676255786 803 789 0.00128760105275506 0.0422197608350738 +PWY_7357_thiamin_formation_from_pyrithiamine__oxythiamine dysbiosisCD Yes 1.12656624773753 0.352354738894867 803 597 0.00147796405880232 0.045230209391779 +GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisCD Yes 1.13569269806603 0.356004363778927 803 706 0.00150594654379153 0.045230209391779 +PWY_6700_queuosine_biosyn diagnosis UC 0.696936803662394 0.214956076299978 803 780 0.00160317757450049 0.045230209391779 +PWY_6897_thiamin_salvage_II dysbiosisCD Yes 1.06527375058191 0.335795364969092 803 589 0.00159563539296119 0.045230209391779 +PWY_4984_urea_cyc dysbiosisUC Yes -1.79683774077562 0.568243937070938 803 665 0.00163351478541738 0.045230209391779 +PWY_7560_methylerythritol_phosphate_pwy_II dysbiosisCD Yes 1.3163941368664 0.415797110052004 803 226 0.00162755959366917 0.045230209391779 +PWY0_862_dodec_5_enoate_biosyn age age -0.526457320871371 0.162097257084328 803 546 0.00162706584207162 0.045230209391779 +RIBOSYN2_PWY_flavin_biosyn_I dysbiosisCD Yes 1.23404231759102 0.393541190009151 803 478 0.00180165000171554 0.0482419683372991 +PWY_6901_SP_of_glucose__xylose_deg diagnosis UC -1.16659244842496 0.363753637210181 803 436 0.00183497224375232 0.0482419683372991 +PWY0_845_SP_of_pyridoxal_5_phosphate_biosyn__salvage dysbiosisUC Yes -1.24803654414667 0.399613795218526 803 754 0.00185843858763271 0.0482419683372991 +PWY_6151_S_adenosyl_L_methionine_cyc_I age age -0.202713904738836 0.0635664845667934 803 791 0.00193221269505651 0.0490815704600589 +PWY_7282_4_amino_2_methyl_5_phosphomethylpyrimidine_biosyn dysbiosisCD Yes 0.997977311365132 0.321390409529009 803 604 0.00199106168029858 0.0490815704600589 +ANAGLYCOLYSIS_PWY_glycolysis_III dysbiosisCD Yes -0.24208299820517 0.0780186791715543 803 801 0.00200895673632665 0.0490815704600589 +PYRIDNUCSYN_PWY_NAD_biosyn_I dysbiosisCD Yes -0.9287510817242 0.300813020394954 803 707 0.00211247850024277 0.0506182348327402 +PWY_5690_TCA_cyc_II diagnosis UC -1.33632761398017 0.425565750329088 803 363 0.00219444765578908 0.0515902222474188 +PWY0_166_SP_of_pyrimidine_dnt_de_novo_biosyn dysbiosisCD Yes -0.634846939391826 0.20675514787451 803 742 0.00225730537506186 0.0520852314319829 +PWY_2942_L_lysine_biosyn_III dysbiosisCD Yes -0.221053593129319 0.0743552011668912 803 802 0.0030601884547503 0.0693271784476159 +PWY_7228_SP_of_guanosine_nt_de_novo_biosyn_I dysbiosisUC Yes 0.759965352103471 0.257891261069081 803 783 0.00330814571295482 0.0736062421132447 +CITRULBIO_PWY_L_citrulline_biosyn dysbiosisUC Yes -1.6541219120814 0.56593390090318 803 688 0.00357826514530312 0.0782196205446963 +PWY_7199_pyrimidine_dns_salvage diagnosis UC -1.23586415204619 0.41599506926134 803 694 0.00367858796367093 0.0790262172885169 +PWY_1042_glycolysis_IV dysbiosisCD Yes -0.236895460432705 0.0821076927389324 803 803 0.00403683091211355 0.0852523951948048 +PWY_5690_TCA_cyc_II diagnosis CD -1.14831016033153 0.393054803391649 803 363 0.00420249951974296 0.0858412196983562 +PWY_5690_TCA_cyc_II dysbiosisCD Yes 1.26338136558261 0.439173202621499 803 363 0.00419041816821215 0.0858412196983562 +PYRIDNUCSYN_PWY_NAD_biosyn_I diagnosis UC -0.976396039843521 0.334014919042906 803 707 0.00435994928725515 0.087620916321289 +PWY_5695_urate_biosyn_inosine_5_phosphate_deg dysbiosisUC Yes -0.420305583437807 0.147629549462274 803 800 0.00453310385983108 0.0896547207833258 +PWY_7219_adenosine_rnt_de_novo_biosyn antibiotics Yes 0.172348923778522 0.0610005693523868 803 803 0.00484677803818674 0.0943607099309481 +PWY_5083_NAD_NADH_phosphorylation__dephosphorylation age age -0.499122848069624 0.17325064658291 803 431 0.00512994054185098 0.0983370140791742 +PWY_5030_L_histidine_deg_III age age 0.669768233550353 0.234451288671946 803 542 0.00528153624565419 0.0994128624150221 +PWY_7221_guanosine_rnt_de_novo_biosyn dysbiosisUC Yes 0.296205466033337 0.106059785568759 803 802 0.00536278912019371 0.0994128624150221 +PWY_5030_L_histidine_deg_III antibiotics Yes -1.1378099419977 0.407939276410625 803 542 0.00542542106277809 0.0994128624150221 +PWYG_321_mycolate_biosyn dysbiosisUC Yes -2.06370193958469 0.742027141373566 803 484 0.00556752612776979 0.100538225437698 +PWY_6608_guanosine_nt_deg_III dysbiosisCD Yes -0.9500595195963 0.342183308463509 803 686 0.00569951193317593 0.101451312410532 +PWY_5676_acetyl_CoA_fermentation_to_butanoate_II dysbiosisCD Yes -1.53795805104683 0.556983075326516 803 459 0.00593878661529487 0.10422152285433 +PWY0_1296_purine_rns_deg age age -0.193563750776857 0.0691608666572281 803 793 0.00622609544541396 0.107746040624803 +PWY4FS_7_phosphatidylglycerol_biosyn_I age age -0.378406559573777 0.137837610777862 803 604 0.00727054230012572 0.119674583304877 +PWY4FS_8_phosphatidylglycerol_biosyn_II age age -0.378406903065047 0.137837660954131 803 604 0.00727051163546652 0.119674583304877 +GLUCUROCAT_PWY_SP_of_beta_D_glucuronide__D_glucuronate_deg antibiotics Yes -0.6298522987308 0.234257658887376 803 755 0.00733986227256078 0.119674583304877 +PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn dysbiosisCD Yes -1.33137496372798 0.494835897030698 803 504 0.00734774069396818 0.119674583304877 +PWY_7199_pyrimidine_dns_salvage dysbiosisUC Yes -1.58461769894282 0.590008867188131 803 694 0.00739562031659351 0.119674583304877 +PWY_5973_cis_vaccenate_biosyn dysbiosisnonIBD Yes 0.734138465085068 0.277280020301585 803 787 0.00827348197417705 0.12921524057127 +THISYNARA_PWY_SP_of_thiamin_diphosphate_biosyn_III dysbiosisCD Yes 0.754318786221792 0.284465658290248 803 682 0.0082436805991518 0.12921524057127 +PWY0_1261_anhydromuropeptides_recycling dysbiosisnonIBD Yes 2.09814252862597 0.792255588571547 803 273 0.00831227953224553 0.12921524057127 +PWY_5971_palmitate_biosyn_II age age -0.383678181929206 0.141550997120608 803 143 0.0084000276775866 0.12921524057127 +PWY_7229_SP_of_adenosine_nt_de_novo_biosyn_I diagnosis UC 0.428338656454306 0.159968996890715 803 792 0.00874074619851681 0.132816704431121 +PWY_6163_chorismate_biosyn_from_3_dehydroquinate dysbiosisCD Yes -0.490331694516463 0.188696017874289 803 787 0.00957676903168428 0.143766918234682 +PANTO_PWY_phosphopantothenate_biosyn_I dysbiosisCD Yes -0.292847321608844 0.113857832466468 803 798 0.0103177493306308 0.153046615071024 +PWY_5690_TCA_cyc_II antibiotics Yes -1.12208062708696 0.437237294255074 803 363 0.0104872613045972 0.153730912770919 +GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisnonIBD Yes 1.5179964283044 0.592931307732504 803 706 0.0106785076434965 0.15471419213717 +COA_PWY_1_coenzyme_A_biosyn_II dysbiosisCD Yes -0.233170588772712 0.091623382614227 803 800 0.0111612451381914 0.157378436002368 +COA_PWY_coenzyme_A_biosyn_I diagnosis UC 0.646197966203477 0.249562397355943 803 774 0.0111643136936702 0.157378436002368 +PWY_6387_UDP_N_acetylmuramoyl_pentapeptide_biosyn_I dysbiosisCD Yes -0.157330733238568 0.0618864576804341 803 799 0.011241316857312 0.157378436002368 +P105_PWY_TCA_cyc_IV diagnosis UC -1.44577315564917 0.560161920928689 803 101 0.0115233549287241 0.157781321331761 +PWYG_321_mycolate_biosyn age age -0.422409603544552 0.16372454925245 803 484 0.0115224152334863 0.157781321331761 +PWY_4984_urea_cyc dysbiosisCD Yes -0.968846384633195 0.38602606767937 803 665 0.0123165946551287 0.165179780079184 +PWY_7237_myo__chiro__scillo_inositol_deg dysbiosisCD Yes 1.24761961443681 0.496570773418466 803 441 0.0123288278871301 0.165179780079184 +PWY_1269_CMP_3_deoxy_D_manno_octulosonate_biosyn_I diagnosis UC -0.607612849125228 0.239459336817358 803 764 0.012604329441017 0.167074409399013 +PWY_6901_SP_of_glucose__xylose_deg diagnosis CD -0.84052191004695 0.335470159271474 803 436 0.0138423909924132 0.181553886068914 +PWY_7219_adenosine_rnt_de_novo_biosyn dysbiosisUC Yes 0.243862775740808 0.0996183085787118 803 803 0.0145977270972915 0.189466332950263 +PWY_5100_pyruvate_fermentation_to_acetate__lactate_II diagnosis CD 0.477304065107603 0.192807701246637 803 778 0.0150099861370422 0.192390340310128 +PWY_7199_pyrimidine_dns_salvage diagnosis CD -0.950684863496419 0.385336377337959 803 694 0.0151318245187741 0.192390340310128 +FASYN_INITIAL_PWY_SP_of_fatty_acid_biosyn_initiation age age -0.574510717329775 0.178679134332171 803 539 0.0153486152425512 0.193175500931503 +RIBOSYN2_PWY_flavin_biosyn_I diagnosis CD -1.00820570940542 0.410741491886951 803 478 0.0158719759498275 0.197764820334851 +PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I dysbiosisCD Yes 1.0409163590731 0.430789374055662 803 557 0.0160703097192685 0.198253523863451 +OANTIGEN_PWY_O_antigen_building_blocks_biosyn dysbiosisCD Yes 0.807347119497748 0.335973887803261 803 445 0.0166034832834305 0.201538217457481 +PWY_7323_SP_of_GDP_mannose_derived_O_antigen_building_blocks_biosyn diagnosis UC -1.27196952378674 0.522122040884236 803 504 0.0166600613147035 0.201538217457481 +GLUCONEO_PWY_gluconeogenesis_I diagnosis UC -2.04706270142405 0.844604302625734 803 457 0.0176548028326441 0.21151811855264 +PWY_5188_tetrapyrrole_biosyn_I dysbiosisCD Yes 0.743025838196263 0.313732912113337 803 731 0.0181508494937043 0.211939077873875 +PWY_6163_chorismate_biosyn_from_3_dehydroquinate diagnosis UC -0.526255995859031 0.219176996864048 803 787 0.0182027417981987 0.211939077873875 +PWY0_162_SP_of_pyrimidine_rnt_de_novo_biosyn antibiotics Yes -0.443131740643846 0.187323411992618 803 761 0.0182597756534306 0.211939077873875 +PWY_7199_pyrimidine_dns_salvage dysbiosisnonIBD Yes -1.4499709029318 0.61392119403375 803 694 0.0184472854019822 0.211939077873875 +P105_PWY_TCA_cyc_IV diagnosis CD -1.22730544833912 0.512148876285502 803 101 0.0185404169247611 0.211939077873875 +PWY_6608_guanosine_nt_deg_III age age -0.454554518614291 0.187723286405032 803 686 0.0188083800516826 0.213047650403605 +PHOSLIPSYN_PWY_SP_of_phospholipid_biosyn_I diagnosis UC -0.920044125219964 0.385872763866869 803 557 0.019018137819772 0.213482880391315 +PWY_5667_CDP_diacylglycerol_biosyn_I dysbiosisUC Yes -0.29835370583141 0.127495273356018 803 801 0.0195424558618911 0.215533337094297 +PWY0_1319_CDP_diacylglycerol_biosyn_II dysbiosisUC Yes -0.29834455205438 0.127495880207699 803 801 0.0195467633159354 0.215533337094297 +GLYCOGENSYNTH_PWY_glycogen_biosyn_I dysbiosisUC Yes 1.34058344043664 0.576860920810617 803 706 0.0203915173347132 0.222875707009234 +TRNA_CHARGING_PWY_tRNA_charging dysbiosisCD Yes -0.770881051243798 0.333199575438021 803 703 0.0210163024192548 0.227507010642096 +PWY_5101_L_isoleucine_biosyn_II dysbiosisnonIBD Yes 1.41211152928141 0.611319589879527 803 574 0.0211804279570491 0.227507010642096 +PWY66_399_gluconeogenesis_III age age 0.413612641234371 0.177250759163526 803 670 0.0217577105918344 0.231710319636117 +P161_PWY_acetylene_deg dysbiosisCD Yes 0.908709966849317 0.397040986171315 803 537 0.0224551761878914 0.23445892946571 +PWY_3841_folate_transformations_II age age 0.137986840851213 0.0595675879634972 803 787 0.0224872238720809 0.23445892946571 +P42_PWY_incomplete_reductive_TCA_cyc dysbiosisUC Yes -1.26959036092065 0.557008145277737 803 636 0.0229295199344193 0.23445892946571 +PWY_7211_SP_of_pyrimidine_dnt_de_novo_biosyn antibiotics Yes -0.706584381124543 0.310039483145919 803 469 0.0229566528048287 0.23445892946571 +PWY_7242_D_fructuronate_deg dysbiosisUC Yes 0.72540730623106 0.317985637087995 803 773 0.0228084538196858 0.23445892946571 +PWY_6353_purine_nt_deg_II dysbiosisnonIBD Yes -1.53413183614004 0.677607456879996 803 432 0.0239140278868041 0.240297409249661 +PWY66_400_glycolysis_VI dysbiosisUC Yes -0.529300554759636 0.233756229286142 803 789 0.0238446945705259 0.240297409249661