diff --git a/.github/workflows/lint.yml b/.github/workflows/lint.yml
index 83902da..0928c3a 100644
--- a/.github/workflows/lint.yml
+++ b/.github/workflows/lint.yml
@@ -12,7 +12,7 @@ jobs:
       - uses: actions/setup-python@v2
         name: Set up Python
         with:
-          python-version: 3.9
+          python-version: '3.10'
       - name: Install flake8
         run: python -m pip install flake8
       - name: Run linter
diff --git a/.github/workflows/release.yml b/.github/workflows/release.yml
new file mode 100644
index 0000000..0ffc5db
--- /dev/null
+++ b/.github/workflows/release.yml
@@ -0,0 +1,30 @@
+name: Release PyPI Package
+on:
+  release:
+
+types: [published]
+
+jobs:
+  publish:
+    runs-on: ubuntu-latest
+
+    permissions:
+      contents: read
+
+    steps:
+      - uses: actions/checkout@v2
+
+      - uses: actions/setup-python@v2
+        with:
+          python-version: '3.10'
+
+      - name: Install build dependencies
+        run: python -m pip install build --user
+
+      - name: Build
+        run: python -m build --sdist --wheel --outdir dist/ .
+
+      - name: Publish to PyPI
+        uses: pypa/gh-action-pypi-publish@release/v1
+        with:
+          password: ${{ secrets.PYPI_API_TOKEN }}
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 0d437ee..1a4ecd1 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -10,7 +10,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python-version: [ 3.6, 3.9 ]
+        python-version: [ '3.8', '3.10' ]
     services:
       redis:
         image: redis
@@ -40,7 +40,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python-version: [ 3.6, 3.9 ]
+        python-version: [ '3.8', '3.10' ]
     steps:
       - uses: actions/checkout@v1
       - uses: actions/setup-python@v2
diff --git a/bento_lib/package.cfg b/bento_lib/package.cfg
index 5c39277..ce86a5a 100644
--- a/bento_lib/package.cfg
+++ b/bento_lib/package.cfg
@@ -1,5 +1,5 @@
 [package]
 name = bento_lib
-version = 3.2.0
+version = 4.0.0
 authors = David Lougheed, Paul Pillot
 author_emails = david.lougheed@mail.mcgill.ca, paul.pillot@computationalgenomics.ca
diff --git a/pypackage.toml b/pypackage.toml
new file mode 100644
index 0000000..d1e6ae6
--- /dev/null
+++ b/pypackage.toml
@@ -0,0 +1,2 @@
+[build-system]
+requires = ["setuptools", "wheel"]
diff --git a/requirements.txt b/requirements.txt
index a6ca2ba..d3ed9a1 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,15 +1,15 @@
 appdirs==1.4.4
-asgiref==3.4.1
+asgiref==3.5.2
 attrs==21.2.0
 backports.entry-points-selectable==1.1.0
-certifi==2021.5.30
+certifi==2022.9.24
 chardet==4.0.0
 charset-normalizer==2.0.4
 click==8.0.1
 codecov==2.1.12
 coverage==5.5
 distlib==0.3.2
-Django==3.2.13
+Django==4.1.1
 djangorestframework==3.12.4
 entrypoints==0.3
 filelock==3.0.12
diff --git a/setup.py b/setup.py
index 6a2711d..2e51b10 100644
--- a/setup.py
+++ b/setup.py
@@ -14,7 +14,7 @@
     name=config["package"]["name"],
     version=config["package"]["version"],
 
-    python_requires=">=3.6",
+    python_requires=">=3.8",
     install_requires=[
         "jsonschema>=3.2.0,<4",
         "psycopg2-binary>=2.8.6,<3.0",
@@ -23,7 +23,7 @@
     ],
     extras_require={
         "flask": ["Flask>=2.0.1,<3"],
-        "django": ["Django>=3.2.7,<4", "djangorestframework>=3.12.4,<3.13"]
+        "django": ["Django>=4.1.1,<5", "djangorestframework>=3.13.1,<3.15"]
     },
 
     author=config["package"]["authors"],