diff --git a/CMakeLists.txt b/CMakeLists.txt
index 075d1a33c636..65747ffe1a8f 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -114,6 +114,8 @@ set_property(DIRECTORY APPEND
 add_dependencies(sof_public_headers genconfig check_version_h)
 target_include_directories(sof_public_headers INTERFACE ${GENERATED_DIRECTORY}/include)
 
+include(scripts/cmake/uuid-registry.cmake)
+
 if(CONFIG_LIBRARY)
 	if (CONFIG_LIBRARY_STATIC)
 		add_library(sof STATIC "")
diff --git a/scripts/cmake/uuid-registry.cmake b/scripts/cmake/uuid-registry.cmake
new file mode 100644
index 000000000000..6d3881543a8f
--- /dev/null
+++ b/scripts/cmake/uuid-registry.cmake
@@ -0,0 +1,30 @@
+#
+# UUID registry generation
+#
+
+is_zephyr(zephyr_is)
+if(zephyr_is)
+  set(TOPDIR ${sof_top_dir})
+  set(UUID_REG_H ${PROJECT_BINARY_DIR}/include/generated/uuid-registry.h)
+  set(DEP_TARGET zephyr_interface)
+elseif(${PROJECT_NAME} STREQUAL "SOF_TPLG_PARSER")
+  set(TOPDIR "${PROJECT_SOURCE_DIR}/../..")
+  set(UUID_REG_H "${PROJECT_BINARY_DIR}/include/uuid-registry.h")
+  set(DEP_TARGET sof_tplg_parser)
+else()
+  # Legacy SOF, or CONFIG_LIBRARY
+  set(TOPDIR ${PROJECT_SOURCE_DIR})
+  set(UUID_REG_H ${PROJECT_BINARY_DIR}/generated/include/uuid-registry.h)
+  set(DEP_TARGET sof_public_headers)
+endif()
+
+add_custom_command(
+	OUTPUT ${UUID_REG_H}
+	COMMAND
+	${PYTHON_EXECUTABLE} ${TOPDIR}/scripts/gen-uuid-reg.py
+	                     ${TOPDIR}/uuid-registry.txt
+			     ${UUID_REG_H})
+
+add_custom_target(uuid_reg_h DEPENDS ${UUID_REG_H})
+
+add_dependencies(${DEP_TARGET} uuid_reg_h)
diff --git a/scripts/gen-uuid-reg.py b/scripts/gen-uuid-reg.py
new file mode 100755
index 000000000000..3bdd7258cca9
--- /dev/null
+++ b/scripts/gen-uuid-reg.py
@@ -0,0 +1,61 @@
+#!/usr/bin/env python3
+# SPDX-License-Identifier: BSD-3-Clause
+import re
+import sys
+
+# Very simple UUID registry validator and C header generator.  Parses
+# uuid-registry.txt (passed as the first command line argument) and
+# writes a C header (named in the second argument) containing
+# definitions to be used at build time.  Fails via assertion if the
+# any element in the registry is invalid.
+
+header = """/*
+ * GENERATED CODE.  DO NOT EDIT.
+ *
+ * Generated UUID records (initializers for struct sof_uuid)
+ * See scripts/gen-uuid-reg.py
+ */
+#ifndef _UUID_REGISTRY_H
+#define _UUID_REGISTRY_H
+"""
+
+all_syms = set()
+all_uuids = set()
+out_recs = []
+
+def emit_uuid_rec(uu, sym):
+    recs = uu.split('-')
+    brec = recs[3]
+    wrecs = [ "0x" + r for r in recs[0:3] ]
+    byts = [ "0x" + brec[ 2*i : 2*i+2 ] for i in range(int(len(brec) / 2)) ]
+    uuidinit = "{ " + ", ".join(wrecs) + ", { " + ", ".join(byts) + " } }"
+    out_recs.append(f"#define _UUIDREG_{sym} {uuidinit}")
+
+def main():
+    with open(sys.argv[1]) as f:
+        for line in f.readlines():
+            line = re.sub(r'\s*#.*', '', line) # trim comments
+            line = re.sub(r'^\s*', '', line)   # trim leading ws
+            line = re.sub(r'\s*$', '', line)   # trim trailing ws
+            if line == "":
+                continue
+            m = re.match(r'(.*)\s+(.*)', line)
+            assert m
+            (uu, sym) = (m.group(1).lower(), m.group(2))
+            assert re.match(r'[0-9a-f]{8}(?:-[0-9a-f]{4}){2}-[0-9a-f]{16}', uu)
+            assert re.match(r'[a-zA-Z_][a-zA-Z0-9_]*', sym)
+            assert len(sym) < 32
+            assert uu not in all_uuids
+            assert sym not in all_syms
+            all_uuids.add(uu)
+            all_syms.add(sym)
+            emit_uuid_rec(uu, sym)
+
+    with open(sys.argv[2], "w") as f:
+        f.write(header)
+        for l in out_recs:
+            f.write(l + "\n")
+        f.write("#endif /* _UUID_REGISTRY_H */\n")
+
+if __name__ == "__main__":
+	main()
diff --git a/src/include/sof/lib/uuid.h b/src/include/sof/lib/uuid.h
index 315e89fa8330..2f58d89f537b 100644
--- a/src/include/sof/lib/uuid.h
+++ b/src/include/sof/lib/uuid.h
@@ -9,6 +9,7 @@
 #define __SOF_LIB_UUID_H__
 
 #include <sof/common.h>
+#include <uuid-registry.h>
 
 #ifdef __ZEPHYR__
 #include <zephyr/sys/iterable_sections.h>
@@ -123,6 +124,18 @@ struct sof_uuid_entry {
 	_DEF_UUID(entity_name, uuid_name,			\
 		  _UUID_INIT(va, vb, vc, vd0, vd1, vd2, vd3, vd4, vd5, vd6, vd7))
 
+/** \brief Defines UUID sourced from the fixed SOF registry
+ *
+ * As for SOF_DEFINE_UUID(), but the ID value is sourced by name from
+ * the uuid-registry.txt file distributed with the source tree. The
+ * string name field will be identical with the name passed (which is
+ * passed as a symbol!), runtime symbol (e.g. the "uuid_name" argument
+ * to SOF_DEFINE_UUID()) will be the same, postfixed with a "_uuid".
+ *
+ * \param name Name of the UUID, must match an entry in uuid-registry.txt
+ */
+#define SOF_DEFINE_REG_UUID(name) _DEF_UUID(#name, name##_uuid, _UUIDREG_##name)
+
 /** \brief Creates local unique 32-bit representation of UUID structure.
  *
  * In Zephyr builds, this has the same address as the result of
diff --git a/tools/tplg_parser/CMakeLists.txt b/tools/tplg_parser/CMakeLists.txt
index 871eaf06c60a..1569284b097d 100644
--- a/tools/tplg_parser/CMakeLists.txt
+++ b/tools/tplg_parser/CMakeLists.txt
@@ -70,6 +70,8 @@ target_compile_options(sof_tplg_parser PRIVATE
 
 target_link_libraries(sof_tplg_parser PRIVATE -lm)
 
+include(../../scripts/cmake/uuid-registry.cmake)
+
 install(DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR}/include/tplg_parser
 	DESTINATION include
 	PATTERN "*.h"
diff --git a/uuid-registry.txt b/uuid-registry.txt
new file mode 100644
index 000000000000..f21859de222d
--- /dev/null
+++ b/uuid-registry.txt
@@ -0,0 +1,158 @@
+#
+# Global UUID/name registry for SOF components.  All IDs used in
+# shipped binary artifacts must appear in this list.  All names must
+# be unique.  All names must be legal C identifiers of at most 31
+# characters.  No change to a previously distributed mapping is
+# allowed, ever.
+#
+# Simple format: "#" indicates a comment to end of line.  Remaining
+# lines must be entirely empty/whitespace, or two whitespace-separated
+# fields of: <UUID> <name>
+#
+# NOTE: the UUID is in a SOF-unique format to match the (nonstandard
+# and endian-ambiguous) representation in struct sof_uuid: the first
+# three entries are specied as little endian dword/word values, the
+# last as an ordered array of 8 bytes.  If you have a value from
+# e.g. an RFC-4122 compliant tool, swap the order of the two bytes in
+# the fourth cluster and prepend it to the last.  Most of the time you
+# are just using random values and won't care about the byte swap.
+#
+
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diff --git a/zephyr/CMakeLists.txt b/zephyr/CMakeLists.txt
index 4ae2b5e0e521..46264a6889ed 100644
--- a/zephyr/CMakeLists.txt
+++ b/zephyr/CMakeLists.txt
@@ -921,6 +921,8 @@ add_definitions(-DXCC_TOOLS_VERSION="${ZEPHYR_TOOLCHAIN_VARIANT}" -DCC_OPTIMIZE_
 # create version information
 include(../scripts/cmake/version.cmake)
 
+include(../scripts/cmake/uuid-registry.cmake)
+
 # Create Trace realtive file paths
 sof_append_relative_path_definitions(modules_sof)