diff --git a/packages/instantsearch.js/src/components/RefinementList/RefinementList.tsx b/packages/instantsearch.js/src/components/RefinementList/RefinementList.tsx
index 885fa80c85..3fcaf35c33 100644
--- a/packages/instantsearch.js/src/components/RefinementList/RefinementList.tsx
+++ b/packages/instantsearch.js/src/components/RefinementList/RefinementList.tsx
@@ -108,8 +108,11 @@ class RefinementList<TTemplates extends Templates> extends Component<
 > {
   public static defaultProps = defaultProps;
 
+  private listRef = createRef<HTMLUListElement>();
   private searchBox = createRef<SearchBox>();
 
+  private lastRefinedValue: string | undefined = undefined;
+
   public shouldComponentUpdate(
     nextProps: RefinementListPropsWithDefaultProps<TTemplates>
   ) {
@@ -122,6 +125,7 @@ class RefinementList<TTemplates extends Templates> extends Component<
   }
 
   private refine(facetValueToRefine: string) {
+    this.lastRefinedValue = facetValueToRefine;
     this.props.toggleRefinement(facetValueToRefine);
   }
 
@@ -270,6 +274,20 @@ class RefinementList<TTemplates extends Templates> extends Component<
     }
   }
 
+  /**
+   * This sets focus on the last refined input element after a render
+   * because Preact does not perform it automatically.
+   * @see https://github.com/preactjs/preact/issues/3242
+   */
+  public componentDidUpdate() {
+    this.listRef.current
+      ?.querySelector<HTMLInputElement>(
+        `input[value="${this.lastRefinedValue}"]`
+      )
+      ?.focus();
+    this.lastRefinedValue = undefined;
+  }
+
   private refineFirstValue() {
     const firstValue = this.props.facetValues && this.props.facetValues[0];
     if (firstValue) {
@@ -330,7 +348,7 @@ class RefinementList<TTemplates extends Templates> extends Component<
 
     const facetValues = this.props.facetValues &&
       this.props.facetValues.length > 0 && (
-        <ul className={this.props.cssClasses.list}>
+        <ul ref={this.listRef} className={this.props.cssClasses.list}>
           {this.props.facetValues.map(this._generateFacetItem, this)}
         </ul>
       );
diff --git a/packages/instantsearch.js/src/components/RefinementList/__tests__/RefinementList-test.tsx b/packages/instantsearch.js/src/components/RefinementList/__tests__/RefinementList-test.tsx
index 51ab4c0a68..ec46893370 100644
--- a/packages/instantsearch.js/src/components/RefinementList/__tests__/RefinementList-test.tsx
+++ b/packages/instantsearch.js/src/components/RefinementList/__tests__/RefinementList-test.tsx
@@ -660,7 +660,7 @@ describe('RefinementList', () => {
               <label>
                 <input type="radio" checked="${item.isRefined}" />
                 ${item.value}
-              </span>
+              </label>
             `,
         showMoreText: '',
       };
diff --git a/tests/common/widgets/refinement-list/options.ts b/tests/common/widgets/refinement-list/options.ts
index 87abf5e225..2c6f3c530e 100644
--- a/tests/common/widgets/refinement-list/options.ts
+++ b/tests/common/widgets/refinement-list/options.ts
@@ -580,6 +580,47 @@ export function createOptionsTests(
       ]);
     });
 
+    test('keeps focus on toggled input between re-renders', async () => {
+      const searchClient = createMockedSearchClient();
+
+      await setup({
+        instantSearchOptions: {
+          indexName: 'indexName',
+          searchClient,
+        },
+        widgetParams: { attribute: 'brand' },
+      });
+
+      await act(async () => {
+        await wait(0);
+      });
+
+      expect(document.activeElement).toEqual(document.body);
+
+      const initialTargetItem = document.querySelector(
+        '.ais-RefinementList-checkbox[value="Samsung"]'
+      )!;
+
+      await act(async () => {
+        /**
+         * Jest wrongly fails the last assertion when running in Vue 3
+         * (`activeElement` is reset to body).
+         * Duplicating the following call fixes this as a workaround,
+         * and doesn't change the objective of this test.
+         */
+        userEvent.click(initialTargetItem);
+        userEvent.click(initialTargetItem);
+        expect(document.activeElement).toEqual(initialTargetItem);
+        await wait(0);
+      });
+
+      const updatedTargetItem = document.querySelector(
+        '.ais-RefinementList-checkbox[value="Samsung"]'
+      )!;
+
+      expect(document.activeElement).toEqual(updatedTargetItem);
+    });
+
     describe('sorting', () => {
       test('sorts the items by ascending name', async () => {
         const searchClient = createMockedSearchClient();