diff --git a/.k8s_ci.Dockerfile b/.k8s_ci.Dockerfile
index 65067806671e..cd4ad9fc7078 100644
--- a/.k8s_ci.Dockerfile
+++ b/.k8s_ci.Dockerfile
@@ -18,7 +18,7 @@
 ARG ROOT_DIR=/galaxy
 ARG SERVER_DIR=$ROOT_DIR/server
 
-ARG STAGE1_BASE=python:3.10-slim
+ARG STAGE1_BASE=python:3.12-slim
 ARG FINAL_STAGE_BASE=$STAGE1_BASE
 ARG GALAXY_USER=galaxy
 ARG GALAXY_PLAYBOOK_REPO=https://github.com/galaxyproject/galaxy-docker-k8s
diff --git a/lib/galaxy/dependencies/conditional-requirements.txt b/lib/galaxy/dependencies/conditional-requirements.txt
index 0f5f82b4efcc..087d825912c8 100644
--- a/lib/galaxy/dependencies/conditional-requirements.txt
+++ b/lib/galaxy/dependencies/conditional-requirements.txt
@@ -1,5 +1,5 @@
 # These dependencies are only required when certain config options are set
-psycopg2-binary==2.9.5
+psycopg2-binary==2.9.9
 mysqlclient
 fluent-logger
 sentry-sdk[fastapi]