Celltype and condition specific GRNs #452
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ctspencer
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* General SCENIC questions
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I have the same questions as well. Wondering have you figured it out? |
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I have a large dataset (>1 million cells) and am attempting to infer celltype and condition-specific GRNs. I ran the SCENIC pipeline after submitting the data by celltype and condition (case/control). I ran AUCell with the celltype/condition-specific regulons of a celltype known to be highly implicated in case samples; however, after Z-score normalization of auc_mtx I do not see the celltype/condition-specific regulons highly enriched in the celltype they come from.
Is AUCell the best way to test for celltype regulon enrichment?
Any suggestions/ideas on why regulons derived from a celltype are not enriched in that celltype against other celltypes in the dataset?
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