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first: thank you for the package along with the data comprehensive book/vignette, it's great!
I was digging a bit deeper in the original Reactome analysis provided by the web-tool and there p-values are corrected by benjamini-hochberg and can be reported and subsequently filtered. Is this correction already implemented in the reactomePA::enrichPathway() function and hence pAdjustMethod = "BH" would be 'double correction'?
I am asking, because setting pAdjustMehthod = "none" give very comparable results to the webtool result, whereas leaving it to "BH" seems to be much more stringent.
What would you suggest?
Kind regards
Thorben
The text was updated successfully, but these errors were encountered:
Hey,
first: thank you for the package along with the data comprehensive book/vignette, it's great!
I was digging a bit deeper in the original Reactome analysis provided by the web-tool and there p-values are corrected by benjamini-hochberg and can be reported and subsequently filtered. Is this correction already implemented in the reactomePA::enrichPathway() function and hence pAdjustMethod = "BH" would be 'double correction'?
I am asking, because setting pAdjustMehthod = "none" give very comparable results to the webtool result, whereas leaving it to "BH" seems to be much more stringent.
What would you suggest?
Kind regards
Thorben
The text was updated successfully, but these errors were encountered: