diff --git a/data/deprecatedIdentifiers/deprecatedReactions.tsv b/data/deprecatedIdentifiers/deprecatedReactions.tsv
index ed26c488..1938f667 100644
--- a/data/deprecatedIdentifiers/deprecatedReactions.tsv
+++ b/data/deprecatedIdentifiers/deprecatedReactions.tsv
@@ -207,7 +207,15 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR01666"	""	""	""	""	"R-HSA-193399"	"HMR_1666"	"MNXR125298"	"HMR_1666"	"RCR20514"	""	0	"RHEA:72683"	"RHEA:72683"	"HMR_1666"
 "MAR01458"	""	"HSD17B4x"	""	""	""	"HSD17B4x"	"MNXR100720"	""	""	""	0	""	""	"HSD17B4x"
 "MAR01651"	"R04812"	""	"RE3250M"	""	""	"HMR_1651"	""	"HMR_1651"	"RCR12831"	""	0	""	""	"HMR_1651"
+"MAR01639"	""	""	"RE3247X;RE3247M"	"r0706"	"R-HSA-192335"	"RE3247X;r0706;HMR_1637;RE3247M"	"MNXR105369;MNXR124225"	"HMR_1639;HMR_1637"	"RCR10917;RCR13607"	""	0	""	""	"HMR_1639;HMR_1637;MAR01637"
+"MAR03301"	""	""	"RE1516X"	""	""	""	""	"HMR_3301"	"RCR12606"	""	0	""	""	"HMR_3301"
+"MAR03306"	""	""	"RE1517X"	""	""	""	""	"HMR_3306"	"RCR12610"	""	0	""	""	"HMR_3306"
+"MAR03311"	""	""	"RE1518X"	""	""	""	""	"HMR_3311"	"RCR14519"	""	0	""	""	"HMR_3311"
+"MAR04966"	""	"FAOXC101C102x"	""	""	""	"FAOXC101C102x"	""	""	""	""	0	""	""	"FAOXC101C102x"
+"MAR03364"	""	""	"RE2913X"	""	""	""	""	"HMR_3364"	"RCR12576"	""	0	""	""	"HMR_3364"
+"MAR03369"	""	""	"RE2914X"	""	""	""	""	"HMR_3369"	"RCR12580"	""	0	""	""	"HMR_3369"
 "MAR09887"	""	"GLNB0AT3tc"	""	""	""	"GLNB0AT3tc"	""	""	""	""	0	""	""	"GLNB0AT3tc"
+"MAR00059"	""	"ACOX22x"	""	""	""	"ACOX22x"	"MNXR95389"	""	""	""	0	""	""	"ACOX22x"
 "MAR00024"	""	""	""	""	""	"HMR_0024"	""	"HMR_0024"	"RCR13367"	""	0	""	""	"HMR_0024"
 "MAR00025"	""	""	""	""	""	"HMR_0025;HMR_0030"	""	"HMR_0025;HMR_0030"	"RCR20226;RCR20227"	""	0	""	""	"HMR_0025;HMR_0030;MAR00030"
 "MAR00026"	""	""	""	""	""	"HMR_0026"	""	"HMR_0026"	"RCR21051"	""	0	""	""	"HMR_0026"
diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
index 1a471bec..a41283bd 100644
--- a/model/Human-GEM.yml
+++ b/model/Human-GEM.yml
@@ -72754,8 +72754,8 @@
       - name: "Xanthine:oxygen oxidoreductase"
       - metabolites: !!omap
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03120x: 1
           - MAM03148x: -1
       - lower_bound: 0
@@ -73258,9 +73258,9 @@
       - name: "Hypoxanthine:oxygen oxidoreductase"
       - metabolites: !!omap
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02159x: -1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03148x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -77642,9 +77642,9 @@
           - MAM01641x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02633x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -78517,9 +78517,9 @@
       - metabolites: !!omap
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02925x: 1
           - MAM02926x: -1
       - lower_bound: 0
@@ -78580,9 +78580,9 @@
       - metabolites: !!omap
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02924x: 1
           - MAM02925x: -1
       - lower_bound: 0
@@ -78700,9 +78700,9 @@
       - metabolites: !!omap
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02921x: 1
           - MAM02923x: -1
       - lower_bound: 0
@@ -78763,9 +78763,9 @@
       - metabolites: !!omap
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02922x: 1
           - MAM02923x: -1
       - lower_bound: 0
@@ -78826,9 +78826,9 @@
       - metabolites: !!omap
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02920x: 1
           - MAM02921x: -1
       - lower_bound: 0
@@ -78889,9 +78889,9 @@
       - metabolites: !!omap
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02920x: 1
           - MAM02922x: -1
       - lower_bound: 0
@@ -79025,9 +79025,9 @@
       - metabolites: !!omap
           - MAM01250x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02504x: -1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02923x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -79084,9 +79084,9 @@
       - metabolites: !!omap
           - MAM01250x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02503x: -1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02812x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -79124,10 +79124,10 @@
       - metabolites: !!omap
           - MAM01250x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02501x: -1
           - MAM02503x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000088826 or ENSG00000148832"
@@ -79861,8 +79861,8 @@
           - MAM01831x: 1
           - MAM01986x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM02880x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -80309,9 +80309,9 @@
           - MAM02007x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000110887"
@@ -81417,10 +81417,10 @@
           - MAM01157x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02426x: -1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -81473,9 +81473,9 @@
       - metabolites: !!omap
           - MAM00556x: 1
           - MAM02039x: 1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02413x: -1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000179761"
@@ -87334,9 +87334,9 @@
           - MAM01638x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02819x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -87375,9 +87375,9 @@
           - MAM01640x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000110887"
@@ -87396,9 +87396,9 @@
           - MAM01740x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000110887"
@@ -94348,8 +94348,8 @@
           - MAM02007x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM02661x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -94367,8 +94367,8 @@
       - metabolites: !!omap
           - MAM01998x: -1
           - MAM02007x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000101323 or ENSG00000116882"
@@ -94882,8 +94882,8 @@
       - name: "superoxide:superoxide oxidoreductase"
       - metabolites: !!omap
           - MAM02039x: -2
-          - MAM02041x: 1
-          - MAM02630x: 1
+          - MAM01803x: 1
+          - MAM01802x: 1
           - MAM02631x: -2
       - lower_bound: 0
       - upper_bound: 1000
@@ -101188,8 +101188,8 @@
       - metabolites: !!omap
           - MAM00113x: -1
           - MAM01664x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -102559,8 +102559,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00110x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03028x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -103121,8 +103121,8 @@
       - metabolites: !!omap
           - MAM00682x: 1
           - MAM01364x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -103226,8 +103226,8 @@
       - metabolites: !!omap
           - MAM00073x: 1
           - MAM01934x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -103298,8 +103298,8 @@
       - metabolites: !!omap
           - MAM00072x: 1
           - MAM00091x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -104650,8 +104650,8 @@
       - metabolites: !!omap
           - MAM00380x: -1
           - MAM01058x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000012779"
@@ -106841,8 +106841,8 @@
       - metabolites: !!omap
           - MAM01119x: 1
           - MAM01120x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -107309,8 +107309,8 @@
       - metabolites: !!omap
           - MAM01121x: 1
           - MAM01122x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -107910,8 +107910,8 @@
       - metabolites: !!omap
           - MAM00026x: 1
           - MAM00582x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -108172,8 +108172,8 @@
       - metabolites: !!omap
           - MAM00258x: -1
           - MAM01037x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -108489,8 +108489,8 @@
       - metabolites: !!omap
           - MAM00027x: 1
           - MAM00587x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -108579,8 +108579,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00423x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM02650x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -108708,8 +108708,8 @@
       - metabolites: !!omap
           - MAM00015x: 1
           - MAM02039x: -3
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM02652x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -116202,10 +116202,10 @@
           - MAM01597x: -11
           - MAM02039x: 11
           - MAM02040x: -11
-          - MAM02041x: 7
+          - MAM01803x: 7
           - MAM02552x: -11
           - MAM02553x: 11
-          - MAM02630x: -7
+          - MAM01802x: -7
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -116225,10 +116225,10 @@
           - MAM01597x: -11
           - MAM02039x: 11
           - MAM02040x: -11
-          - MAM02041x: 6
+          - MAM01803x: 6
           - MAM02552x: -11
           - MAM02553x: 11
-          - MAM02630x: -6
+          - MAM01802x: -6
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -116248,10 +116248,10 @@
           - MAM01597x: -11
           - MAM02039x: 3
           - MAM02040x: -11
-          - MAM02041x: 11
+          - MAM01803x: 11
           - MAM02552x: -11
           - MAM02553x: 11
-          - MAM02630x: -11
+          - MAM01802x: -11
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -116267,9 +116267,9 @@
       - name: ""
       - metabolites: !!omap
           - MAM00049x: 1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02110x: -1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -116339,8 +116339,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00064x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM02971x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -116412,8 +116412,8 @@
       - metabolites: !!omap
           - MAM00040x: 1
           - MAM01725x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -116484,8 +116484,8 @@
       - metabolites: !!omap
           - MAM00043x: 1
           - MAM01773x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -116555,8 +116555,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00057x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM02941x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -116627,8 +116627,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00051x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM02678x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -116699,9 +116699,9 @@
       - name: ""
       - metabolites: !!omap
           - MAM00066x: 1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02495x: -1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -116771,9 +116771,9 @@
       - name: ""
       - metabolites: !!omap
           - MAM00042x: 1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02345x: -1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -116844,8 +116844,8 @@
       - metabolites: !!omap
           - MAM00039x: 1
           - MAM01650x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -116915,8 +116915,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00059x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM02644x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -116987,9 +116987,9 @@
       - name: ""
       - metabolites: !!omap
           - MAM00053x: 1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02122x: -1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -117060,8 +117060,8 @@
       - metabolites: !!omap
           - MAM01412x: -1
           - MAM01622x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -117132,10 +117132,10 @@
           - MAM01597x: -10
           - MAM02039x: 10
           - MAM02040x: -10
-          - MAM02041x: 10
+          - MAM01803x: 10
           - MAM02552x: -10
           - MAM02553x: 10
-          - MAM02630x: -10
+          - MAM01802x: -10
           - MAM02774x: 1
           - MAM03047x: -1
       - lower_bound: 0
@@ -117152,9 +117152,9 @@
       - id: "MAR03326"
       - name: ""
       - metabolites: !!omap
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02112x: -1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03016x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -117225,8 +117225,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00025x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03015x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -117297,8 +117297,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00016x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03013x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -117369,8 +117369,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00007x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03012x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -117440,8 +117440,8 @@
       - id: "MAR03342"
       - name: ""
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM02647x: -1
           - MAM03025x: 1
       - lower_bound: 0
@@ -117513,8 +117513,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM01191x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03019x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -117585,8 +117585,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM01141x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03022x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -117668,24 +117668,6 @@
       - subsystem:
           - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03364"
-      - name: ""
-      - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
-          - MAM02677x: -1
-          - MAM03020x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
-      - rxnNotes: ""
-      - rxnFrom: "HMRdatabase"
-      - eccodes: "1.3.3.6"
-      - references: "PMID:1047780;PMID:8973539;PMID:11135616"
-      - subsystem:
-          - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03365"
       - name: ""
@@ -117740,24 +117722,6 @@
       - subsystem:
           - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03369"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00118x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
-          - MAM03023x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
-      - rxnNotes: ""
-      - rxnFrom: "HMRdatabase"
-      - eccodes: "1.3.3.6"
-      - references: "PMID:1047780;PMID:8973539;PMID:11135616"
-      - subsystem:
-          - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03370"
       - name: ""
@@ -117978,8 +117942,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00078x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03027x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -118051,8 +118015,8 @@
       - metabolites: !!omap
           - MAM00090x: 1
           - MAM00948x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -118139,8 +118103,8 @@
       - metabolites: !!omap
           - MAM00079x: 1
           - MAM00080x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
@@ -118221,24 +118185,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03301"
-      - name: ""
-      - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02391x: -1
-          - MAM02630x: -1
-          - MAM03010x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
-      - rxnNotes: ""
-      - rxnFrom: "HMRdatabase"
-      - eccodes: "1.3.3.6"
-      - references: "PMID:8973539;PMID:10407780;PMID:11356167"
-      - subsystem:
-          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03302"
       - name: ""
@@ -118293,24 +118239,6 @@
       - subsystem:
           - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03306"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01577x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
-          - MAM03009x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
-      - rxnNotes: ""
-      - rxnFrom: "HMRdatabase"
-      - eccodes: "1.3.3.6"
-      - references: "PMID:8973539;PMID:10407780;PMID:11356167"
-      - subsystem:
-          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03307"
       - name: ""
@@ -118365,24 +118293,6 @@
       - subsystem:
           - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03311"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01576x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
-          - MAM03030x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
-      - rxnNotes: ""
-      - rxnFrom: "HMRdatabase"
-      - eccodes: "1.3.3.6"
-      - references: "PMID:8973539;PMID:10407780;PMID:11356167"
-      - subsystem:
-          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03312"
       - name: ""
@@ -120741,8 +120651,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00018x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03014x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -120813,8 +120723,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM01586x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03024x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -145008,25 +144918,7 @@
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.3.3.6;1.17.99.-"
-      - references: "PMID:10709654"
-      - subsystem:
-          - "Bile acid biosynthesis"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR01639"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00618x: -1
-          - MAM00749x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
-      - rxnNotes: ""
-      - rxnFrom: "HMRdatabase"
-      - eccodes: "1.3.3.6;1.17.99.-"
-      - references: "PMID:11356170;PMID:8943006;PMID:10709654"
+      - references: "PMID:11356170;PMID:8943006"
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
@@ -145638,8 +145530,8 @@
       - metabolites: !!omap
           - MAM00617x: -1
           - MAM00755x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000168306"
@@ -145659,11 +145551,11 @@
           - MAM02040x: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000060971 and ENSG00000113790 and ENSG00000133835"
+      - gene_reaction_rule: "ENSG00000113790 or ENSG00000133835"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "4.2.1.107"
-      - references: "PMID:8902629"
+      - references: "PMID:8902629;PMID:19357427"
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
@@ -161793,8 +161685,8 @@
       - name: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase"
       - metabolites: !!omap
           - MAM02040x: 2
-          - MAM02041x: -2
-          - MAM02630x: 1
+          - MAM01803x: -2
+          - MAM01802x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000121691 or ENSG00000166016"
@@ -218610,25 +218502,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00059"
-      - name: "Acyl-Coenzyme A Oxidase 2, Branched Chain"
-      - metabolites: !!omap
-          - MAM00037x: 1
-          - MAM00755x: -1
-          - MAM01802x: 1
-          - MAM01803x: -1
-          - MAM02630x: -0.5
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000168306"
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "1.3.3.6"
-      - references: "PMID:11181649"
-      - subsystem:
-          - "Bile acid biosynthesis"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00060"
       - name: "O-Acetylcarnintine Transport into Mitochondria via Diffusion"
@@ -220672,8 +220545,8 @@
           - MAM00558x: 1
           - MAM01742x: -1
           - MAM02039x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000110887"
@@ -222181,10 +222054,10 @@
           - MAM01597x: -4
           - MAM02039x: 4
           - MAM02040x: -4
-          - MAM02041x: 4
+          - MAM01803x: 4
           - MAM02552x: -4
           - MAM02553x: 4
-          - MAM02630x: -4
+          - MAM01802x: -4
           - MAM02644x: 1
           - MAM02678x: -1
       - lower_bound: 0
@@ -222301,10 +222174,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02678x: 1
           - MAM02941x: -1
       - lower_bound: 0
@@ -222494,10 +222367,10 @@
           - MAM01934x: -1
           - MAM02039x: 5
           - MAM02040x: -5
-          - MAM02041x: 2
+          - MAM01803x: 2
           - MAM02552x: -5
           - MAM02553x: 5
-          - MAM02630x: -2
+          - MAM01802x: -2
           - MAM02644x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -222542,10 +222415,10 @@
           - MAM01597x: -5
           - MAM02039x: 5
           - MAM02040x: -5
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -5
           - MAM02553x: 5
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02644x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -222590,10 +222463,10 @@
           - MAM01773x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02941x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -222754,10 +222627,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ENSG00000060971 and ENSG00000133835 and ENSG00000161533) or (ENSG00000060971 and ENSG00000113790 and ENSG00000161533)"
@@ -222802,10 +222675,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ENSG00000060971 and ENSG00000133835 and ENSG00000161533) or (ENSG00000060971 and ENSG00000113790 and ENSG00000161533)"
@@ -222869,10 +222742,10 @@
           - MAM01773x: 1
           - MAM02039x: 2
           - MAM02040x: -2
-          - MAM02041x: 2
+          - MAM01803x: 2
           - MAM02552x: -2
           - MAM02553x: 2
-          - MAM02630x: -2
+          - MAM01802x: -2
           - MAM02971x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -222893,10 +222766,10 @@
           - MAM01597x: -3
           - MAM02039x: 3
           - MAM02040x: -3
-          - MAM02041x: 3
+          - MAM01803x: 3
           - MAM02552x: -3
           - MAM02553x: 3
-          - MAM02630x: -3
+          - MAM01802x: -3
           - MAM02647x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -222918,10 +222791,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ENSG00000060971 and ENSG00000133835 and ENSG00000161533) or (ENSG00000060971 and ENSG00000113790 and ENSG00000161533)"
@@ -222942,10 +222815,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ENSG00000060971 and ENSG00000133835 and ENSG00000161533) or (ENSG00000060971 and ENSG00000113790 and ENSG00000161533)"
@@ -222966,10 +222839,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ENSG00000060971 and ENSG00000133835 and ENSG00000161533) or (ENSG00000060971 and ENSG00000113790 and ENSG00000161533)"
@@ -222990,10 +222863,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ENSG00000060971 and ENSG00000133835 and ENSG00000161533) or (ENSG00000060971 and ENSG00000113790 and ENSG00000161533)"
@@ -223012,11 +222885,11 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02110x: -1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02971x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -225444,10 +225317,10 @@
           - MAM01597x: -3
           - MAM02039x: 5
           - MAM02040x: -3
-          - MAM02041x: 2
+          - MAM01803x: 2
           - MAM02552x: -3
           - MAM02553x: 3
-          - MAM02630x: -2
+          - MAM01802x: -2
           - MAM02774x: 2
           - MAM03554x: 1
           - MAM03887x: -1
@@ -230768,11 +230641,11 @@
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
       - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "1.3.99.13"
+      - rxnFrom: "Recon3D;HMRdatabase"
+      - eccodes: "1.3.99.13;1.3.3.6"
       - references: "PMID:10407780;PMID:11356167;PMID:8973539"
       - subsystem:
-          - "Fatty acid oxidation"
+          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
       - confidence_score: 0
     - !!omap
       - id: "MAR02808"
@@ -230786,11 +230659,11 @@
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
       - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "1.3.99.13"
+      - rxnFrom: "Recon3D;HMRdatabase"
+      - eccodes: "1.3.99.13;1.3.3.6"
       - references: "PMID:10407780;PMID:11356167;PMID:8973539"
       - subsystem:
-          - "Fatty acid oxidation"
+          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
       - confidence_score: 0
     - !!omap
       - id: "MAR02810"
@@ -230804,11 +230677,11 @@
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
       - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "1.3.99.13"
+      - rxnFrom: "Recon3D;HMRdatabase"
+      - eccodes: "1.3.99.13;1.3.3.6"
       - references: "PMID:10407780;PMID:11356167;PMID:8973539"
       - subsystem:
-          - "Fatty acid oxidation"
+          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
       - confidence_score: 0
     - !!omap
       - id: "MAR02818"
@@ -230824,7 +230697,7 @@
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: "1.3.99.13"
-      - references: "PMID:10407780;PMID:11356167;PMID:8973539"
+      - references: "PMID:10407780;PMID:11356167;PMID:8973539;PMID:18536048;PMID:17458872"
       - subsystem:
           - "Fatty acid oxidation"
       - confidence_score: 0
@@ -232776,11 +232649,11 @@
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
       - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "1.3.99.3"
+      - rxnFrom: "Recon3D;HMRdatabase"
+      - eccodes: "1.3.99.3;1.3.3.6"
       - references: "PMID:1047780;PMID:11135616;PMID:8973539"
       - subsystem:
-          - "Fatty acid oxidation"
+          - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
       - confidence_score: 0
     - !!omap
       - id: "MAR03289"
@@ -232794,11 +232667,11 @@
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
       - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "1.3.99.3"
+      - rxnFrom: "Recon3D;HMRdatabase"
+      - eccodes: "1.3.99.3;1.3.3.6"
       - references: "PMID:1047780;PMID:11135616;PMID:8973539"
       - subsystem:
-          - "Fatty acid oxidation"
+          - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
       - confidence_score: 0
     - !!omap
       - id: "MAR03291"
@@ -236300,8 +236173,8 @@
       - id: "MAR04001"
       - name: "Acyl Coenzyme A Oxidase"
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03021x: 1
           - MAM03352x: -1
       - lower_bound: 0
@@ -239789,24 +239662,6 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR04966"
-      - name: "Fatty Acid Beta Oxidation (C10:1->C10:2), Peroxisomal"
-      - metabolites: !!omap
-          - MAM00678x: 1
-          - MAM00980x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000161533"
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: ""
-      - references: "PMID:18536048;PMID:17458872"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR04967"
       - name: "Fatty Acid Beta Oxidation (C10:1->C8), Mitochondrial"
@@ -239911,8 +239766,8 @@
       - id: "MAR04981"
       - name: "Fatty Acid Beta Oxidation (C10:2->C10:3), Peroxisomal"
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03542x: -1
           - MAM03545x: 1
       - lower_bound: 0
@@ -240091,10 +239946,10 @@
           - MAM01650x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02644x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -240114,10 +239969,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03922x: 1
           - MAM03924x: -1
       - lower_bound: 0
@@ -240137,10 +239992,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02774x: 1
           - MAM03554x: 1
           - MAM04004x: -1
@@ -240387,11 +240242,11 @@
           - MAM01650x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02345x: -1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000060971 and ENSG00000113790 and ENSG00000133835 and ENSG00000161533"
@@ -240429,10 +240284,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03491x: -1
           - MAM03924x: 1
       - lower_bound: 0
@@ -240506,10 +240361,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM04004x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -240579,10 +240434,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000060971 and ENSG00000113790 and ENSG00000133835 and ENSG00000161533"
@@ -240644,10 +240499,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03203x: 1
           - MAM03978x: -1
       - lower_bound: 0
@@ -240711,10 +240566,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03211x: 1
           - MAM03288x: -1
       - lower_bound: 0
@@ -240759,12 +240614,12 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02345x: 1
           - MAM02495x: -1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000060971 and ENSG00000113790 and ENSG00000133835 and ENSG00000161533"
@@ -240802,10 +240657,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03491x: 1
           - MAM03492x: -1
       - lower_bound: 0
@@ -240846,10 +240701,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02774x: 1
           - MAM03887x: -1
       - lower_bound: 0
@@ -240962,10 +240817,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000060971 and ENSG00000113790 and ENSG00000133835 and ENSG00000161533"
@@ -241106,8 +240961,8 @@
       - id: "MAR05196"
       - name: "Fatty Acid Beta Oxidation (C16:3->C16:4), Peroxisomal"
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03274x: -1
           - MAM03653x: 1
       - lower_bound: 0
@@ -241259,8 +241114,8 @@
       - id: "MAR05300"
       - name: "Fatty Acid Beta Oxidation (C16:4->C16:5), Peroxisomal"
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03273x: -1
           - MAM03656x: 1
       - lower_bound: 0
@@ -241394,11 +241249,11 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02495x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02678x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -241437,10 +241292,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03492x: 1
           - MAM03655x: -1
       - lower_bound: 0
@@ -241551,10 +241406,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03789x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -241753,10 +241608,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03273x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -241865,10 +241720,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03567x: -1
           - MAM03789x: 1
       - lower_bound: 0
@@ -241909,8 +241764,8 @@
       - id: "MAR05374"
       - name: "Fatty Acid Beta Oxidation (C20:4->C20:5), Peroxisomal"
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03570x: 1
           - MAM03571x: -1
       - lower_bound: 0
@@ -241977,10 +241832,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03555x: -1
           - MAM03567x: 1
       - lower_bound: 0
@@ -242060,8 +241915,8 @@
       - name: "Fatty Acid Beta Oxidation (C22:5->C22:6), Peroxisomal"
       - metabolites: !!omap
           - MAM00093x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03557x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -242228,10 +242083,10 @@
           - MAM01773x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000060971 and ENSG00000113790 and ENSG00000133835 and ENSG00000161533"
@@ -242292,10 +242147,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03555x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -242316,10 +242171,10 @@
           - MAM01725x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02971x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -242559,11 +242414,11 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02122x: -1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000060971 and ENSG00000113790 and ENSG00000133835 and ENSG00000161533"
@@ -242582,10 +242437,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02944x: 1
           - MAM03409x: -1
       - lower_bound: 0
@@ -242654,10 +242509,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03659x: 1
           - MAM03794x: -1
       - lower_bound: 0
@@ -242702,11 +242557,11 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02122x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM02644x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -242726,10 +242581,10 @@
           - MAM01597x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
+          - MAM01803x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03409x: 1
           - MAM03922x: -1
       - lower_bound: 0
@@ -273888,8 +273743,8 @@
       - name: "Formation of 3-Hydroxy-Adipoyl Coa"
       - metabolites: !!omap
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03213x: 1
           - MAM03409x: -1
       - lower_bound: 0
@@ -273973,8 +273828,8 @@
       - name: "Formation of 3-Hydroxy-Sebacoyl Coa"
       - metabolites: !!omap
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03259x: 1
           - MAM03924x: -1
       - lower_bound: 0
@@ -274058,8 +273913,8 @@
       - name: "Formation of 3-Hydoxy-Suberyl Coa"
       - metabolites: !!omap
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01803x: 1
+          - MAM01802x: -1
           - MAM03261x: 1
           - MAM03922x: -1
       - lower_bound: 0
@@ -288224,10 +288079,10 @@
           - MAM01597x: -2
           - MAM02039x: 2
           - MAM02040x: -2
-          - MAM02041x: 2
+          - MAM01803x: 2
           - MAM02552x: -2
           - MAM02553x: 2
-          - MAM02630x: -1
+          - MAM01802x: -1
           - MAM03236x: -1
           - MAM03238x: 1
       - lower_bound: 0
@@ -295905,12 +295760,12 @@
           - MAM01597x: -4
           - MAM02039x: 3
           - MAM02040x: -2
-          - MAM02041x: 2
+          - MAM01803x: 2
           - MAM02552x: -4
           - MAM02553x: 4
           - MAM02554x: 1
           - MAM02555x: -1
-          - MAM02630x: -2
+          - MAM01802x: -2
           - MAM03580x: -1
           - MAM03893x: 1
       - lower_bound: 0
@@ -304929,7 +304784,7 @@
       - confidence_score: 0
     - !!omap
       - id: "MAR20113"
-      - name: "MAR20114"
+      - name: "MAR20113"
       - metabolites: !!omap
           - MAM00185c: -1
           - MAM00185m: 1
@@ -304943,6 +304798,24 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
+    - !!omap
+      - id: "MAR20114"
+      - name: "MAR20014"
+      - metabolites: !!omap
+          - MAM01802x: 1
+          - MAM01803x: -1
+          - MAM02630x: -1
+          - MAM02041x: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "ENSG00000161533 or ENSG00000168306 or ENSG00000087008 or ENSG00000110887 or ENSG00000203797 or ENSG00000007171 or ENSG00000148832 or ENSG00000179761 or ENSG00000158125"
+      - rxnNotes: ""
+      - rxnFrom: ""
+      - eccodes: ""
+      - references: "PMID:30378035"
+      - subsystem:
+          - "Miscellaneous"
+      - confidence_score: 0
 - genes:
     - !!omap
       - id: "ENSG00000000419"
diff --git a/model/reactions.tsv b/model/reactions.tsv
index fd97e6a7..c79c8937 100644
--- a/model/reactions.tsv
+++ b/model/reactions.tsv
@@ -2584,11 +2584,9 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR03352"	""	""	""	""	""	"HMR_3352"	""	"HMR_3352"	"RCR12573"	""	0	""	""	"HMR_3352"
 "MAR03353"	""	""	""	""	""	"HMR_3353"	""	"HMR_3353"	"RCR12574"	""	0	""	""	"HMR_3353"
 "MAR03355"	"R04100"	"DCIm"	""	""	""	"FAOXC121x"	"MNXR97183"	"HMR_3355"	"RCR12575"	""	0	"RHEA:23719"	"RHEA:23716"	"HMR_3355"
-"MAR03364"	""	""	"RE2913X"	""	""	""	""	"HMR_3364"	"RCR12576"	""	0	""	""	"HMR_3364"
 "MAR03365"	""	""	"RE2919X"	""	""	"RE2919X"	""	"HMR_3365"	"RCR12577"	""	0	""	""	"HMR_3365"
 "MAR03367"	""	""	"RE2908X"	""	""	"RE2908X"	""	"HMR_3367"	"RCR12578"	""	0	""	""	"HMR_3367"
 "MAR03368"	""	""	"RE2916X"	""	""	"RE2916X"	""	"HMR_3368"	"RCR12579"	""	0	""	""	"HMR_3368"
-"MAR03369"	""	""	"RE2914X"	""	""	""	""	"HMR_3369"	"RCR12580"	""	0	""	""	"HMR_3369"
 "MAR03370"	""	""	"RE2920X"	""	""	"RE2920X"	""	"HMR_3370"	"RCR12581"	""	0	""	""	"HMR_3370"
 "MAR03372"	""	""	"RE2909X"	""	""	"RE2909X"	""	"HMR_3372"	"RCR12582"	""	0	""	""	"HMR_3372"
 "MAR03373"	""	""	"RE2917X"	""	""	"RE2917X"	""	"HMR_3373"	"RCR12583"	""	0	""	""	"HMR_3373"
@@ -2615,15 +2613,12 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR03514"	""	""	"RE3093X"	""	""	"RE3093X"	""	"HMR_3514"	"RCR12604"	""	0	""	""	"HMR_3514"
 "MAR03515"	""	""	"RE3090X"	""	""	"RE3090X"	""	"HMR_3515"	"RCR12605"	""	0	""	""	"HMR_3515"
 "MAR03517"	""	"SCP22x"	"RT0781"	""	""	"SCP22x"	"MNXR104294"	"HMR_3517"	"RCR20504"	""	0	""	""	"HMR_3517;SCP22x;MAR01709"
-"MAR03301"	""	""	"RE1516X"	""	""	""	""	"HMR_3301"	"RCR12606"	""	0	""	""	"HMR_3301"
 "MAR03302"	""	""	"RE1523X"	""	""	"RE1523X"	""	"HMR_3302"	"RCR12607"	""	0	""	""	"HMR_3302"
 "MAR03304"	""	""	"RE0512X"	""	""	"RE0512X"	""	"HMR_3304"	"RCR12608"	""	0	""	""	"HMR_3304"
 "MAR03305"	""	""	"RE1531X"	""	""	"RE1531X"	""	"HMR_3305"	"RCR12609"	""	0	""	""	"HMR_3305"
-"MAR03306"	""	""	"RE1517X"	""	""	""	""	"HMR_3306"	"RCR12610"	""	0	""	""	"HMR_3306"
 "MAR03307"	""	""	"RE1522X"	""	""	"RE1522X"	""	"HMR_3307"	"RCR12611"	""	0	""	""	"HMR_3307"
 "MAR03309"	""	""	"RE1525X"	""	""	"RE1525X"	""	"HMR_3309"	"RCR12612"	""	0	""	""	"HMR_3309"
 "MAR03310"	""	""	"RE1532X"	""	""	"RE1532X"	""	"HMR_3310"	"RCR12613"	""	0	""	""	"HMR_3310"
-"MAR03311"	""	""	"RE1518X"	""	""	""	""	"HMR_3311"	"RCR14519"	""	0	""	""	"HMR_3311"
 "MAR03312"	""	""	"RE1521X"	""	""	"RE1521X"	""	"HMR_3312"	"RCR14520"	""	0	""	""	"HMR_3312"
 "MAR03314"	""	""	"RE1526X"	""	""	"RE1526X"	""	"HMR_3314"	"RCR12614"	""	0	""	""	"HMR_3314"
 "MAR03315"	""	""	"RE1533X"	""	""	"RE1533X"	""	"HMR_3315"	"RCR12615"	""	0	""	""	"HMR_3315"
@@ -4036,13 +4031,12 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR01627"	"R08733"	""	""	""	"R-HSA-193401"	"HMR_1627"	"MNXR112239"	"HMR_1627"	"RCR10394"	""	0	""	""	"HMR_1627"
 "MAR01629"	""	""	""	""	"R-HSA-192325"	"HMR_1629;HMR_1630"	"MNXR125295"	"HMR_1629;HMR_1630"	"RCR20233;RCR20511"	""	0	""	""	"HMR_1629"
 "MAR01631"	""	""	""	""	"R-HSA-192325"	"HMR_1631"	"MNXR125295"	"HMR_1631"	"RCR20512"	""	0	""	""	"HMR_1631"
-"MAR01632"	"R08734"	""	"RE2624X"	""	"R-HSA-192056"	"AMACRp;RE2624X;HMR_1635;RE2624M"	"MNXR112240"	"HMR_1632;HMR_1635"	"RCR10915;RCR13606"	""	0	"RHEA:40456"	"RHEA:40455"	"HMR_1632"
-"MAR01638"	""	"ACOX2x"	"RE3247M"	"r0706"	"R-HSA-192335"	"ACOX2x;HMR_1637;RE3247M"	"MNXR105369;MNXR124225"	"HMR_1638;HMR_1637"	"RCR10916;RCR13607"	""	0	""	""	"HMR_1638"
-"MAR01639"	""	""	"RE3247X;RE3247M"	"r0706"	"R-HSA-192335"	"RE3247X;r0706;HMR_1637;RE3247M"	"MNXR105369;MNXR124225"	"HMR_1639;HMR_1637"	"RCR10917;RCR13607"	""	0	""	""	"HMR_1639;HMR_1637;MAR01637"
-"MAR01642"	"R04813"	"HSD17B4x"	"RE3248M"	"r0744"	"R-HSA-192331"	"r0744;HMR_1644;HSD17B4x"	"MNXR105377;MNXR109137;MNXR115598;MNXR100720"	"HMR_1642;HMR_1644"	"RCR10918;RCR12830"	""	0	""	"RHEA:18933"	"HMR_1642;HMR_1644;MAR01644;HSD17B4x;MAR01458"
-"MAR01646"	"R04812"	"HSD17B4x"	"RE3250M"	"r0743"	""	"r0743;HMR_1651;HSD17B4x"	"MNXR105376;MNXR109136;MNXR100720"	"HMR_1646;HMR_1651"	"RCR13608;RCR12831"	""	0	""	""	"HMR_1646;HMR_1651;MAR01651;HSD17B4x;MAR01458"
-"MAR01652"	"R03719"	"SCPx"	"R03719X"	"r0628"	""	"SCPx;HMR_1653"	"MNXR104297;MNXR108369"	"HMR_1652;HMR_1653"	"RCR13609;RCR13610"	""	0	""	"RHEA:16865"	"HMR_1652;HMR_1653;MAR01653"
-"MAR01659"	""	""	""	"r2501;r0990"	""	"r2501;r0990"	"MNXR106313;MNXR105412"	"HMR_1659;HMR_1656"	"RCR20234;RCR20134"	"3.A.1.203.3"	0	""	""	"HMR_1659;HMR_1565;MAR01656"
+"MAR01632"	"R08734"	""	"RE2624X"	""	"R-HSA-192056"	"AMACRp;RE2624X"	"MNXR112240"	"HMR_1632"	"RCR10915"	""	0	"RHEA:40456"	"RHEA:40455"	"HMR_1632"
+"MAR01638"	""	"ACOX2x"	"RE3247X"	"r0706"	"R-HSA-192335"	"ACOX2x;RE3247X;r0706"	"MNXR105369;MNXR124225"	"HMR_1638;HMR_1639"	"RCR10916;RCR10917"	""	0	""	""	"HMR_1638;HMR_1639;MAR01639"
+"MAR01642"	"R04813"	""	""	"r0744"	"R-HSA-192331"	"r0744"	"MNXR105377;MNXR109137;MNXR115598"	"HMR_1642"	"RCR10918"	""	0	""	"RHEA:18933"	"HMR_1642"
+"MAR01646"	"R04812"	""	""	"r0743"	""	"r0743"	"MNXR105376;MNXR109136"	"HMR_1646"	"RCR13608"	""	0	""	""	"HMR_1646"
+"MAR01652"	"R03719"	"SCPx"	"R03719X"	"r0628"	""	"SCPx"	"MNXR104297;MNXR108369"	"HMR_1652"	"RCR13609"	""	0	""	"RHEA:16865"	"HMR_1652"
+"MAR01659"	""	""	""	"r2501"	""	"r2501"	"MNXR106313"	"HMR_1659"	"RCR20234"	"3.A.1.203.3"	0	""	""	"HMR_1659"
 "MAR01660"	"R07296"	""	"RE1834C"	"r0794"	""	"RE1834C"	"MNXR103558;MNXR110971"	"HMR_1660"	"RCR10217"	""	0	"RHEA:14542"	"RHEA:14541"	"HMR_1660"
 "MAR01663"	"R07296"	""	"RE1834X;RE1834M"	""	""	"RE1834X;RE1834M"	"MNXR103558;MNXR110971"	"HMR_1663;HMR_1662"	"RCR13612;RCR13611"	""	0	"RHEA:14542"	"RHEA:14541"	"HMR_1663;HMR_1662;MAR01662"
 "MAR01665"	""	""	""	""	"R-HSA-193399"	"HMR_1665;HMR_1666"	"MNXR125298"	"HMR_1665;HMR_1666"	"RCR20513;RCR20514"	""	0	"RHEA:72683"	"RHEA:72683"	"HMR_1665;HMR_1666;MAR01666"
@@ -8083,7 +8077,6 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR00056"	""	"ACACtx"	""	""	""	"ACACtx"	"MNXR95208"	""	""	""	0	"RHEA:29754"	"RHEA:29751"	"ACACtx"
 "MAR00057"	""	"ACCOAtr"	""	""	""	"ACCOAtr"	"MNXR95223"	""	""	""	0	""	""	"ACCOAtr"
 "MAR00058"	""	"ACHVESSEC"	""	""	""	"ACHVESSEC"	"MNXR95266"	""	""	""	0	""	""	"ACHVESSEC"
-"MAR00059"	""	"ACOX22x"	""	""	""	"ACOX22x"	"MNXR95389"	""	""	""	0	""	""	"ACOX22x"
 "MAR00060"	""	"ACRNtm"	""	""	""	"ACRNtm"	"MNXR95412"	""	""	""	0	""	""	"ACRNtm"
 "MAR00061"	""	"ACt2m"	""	""	""	"ACt2m"	"MNXR95429"	""	""	""	0	""	""	"ACt2m"
 "MAR00062"	""	"ADPRDPm"	""	""	""	"ADPRDPm"	"MNXR95480"	""	""	""	0	""	""	"ADPRDPm"
@@ -8750,10 +8743,10 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR02784"	""	"RE1448N"	""	""	""	"RE1448N"	"MNXR103512"	""	""	""	0	""	""	"RE1448N"
 "MAR02786"	""	""	""	""	""	"RE1514M"	""	""	""	""	0	""	""	"RE1514M"
 "MAR02802"	""	""	""	""	""	"RE1514X"	""	""	""	""	0	""	""	"RE1514X"
-"MAR02804"	""	"RE1516X"	""	""	""	"RE1516X"	""	""	""	""	0	""	""	"RE1516X"
-"MAR02808"	""	"RE1517X"	""	""	""	"RE1517X"	""	""	""	""	0	""	""	"RE1517X"
-"MAR02810"	""	"RE1518X"	""	""	""	"RE1518X"	""	""	""	""	0	""	""	"RE1518X"
-"MAR02818"	""	"RE1519X"	""	""	""	"RE1519X"	""	""	""	""	0	""	""	"RE1519X"
+"MAR02804"	""	"RE1516X"	"RE1516X"	""	""	"RE1516X"	""	"HMR_3301"	"RCR12606"	""	0	""	""	"RE1516X;HMR_3301"
+"MAR02808"	""	"RE1517X"	"RE1517X"	""	""	"RE1517X"	""	"HMR_3306"	"RCR12610"	""	0	""	""	"RE1517X;HMR_3306;MAR00306"
+"MAR02810"	""	"RE1518X"	"RE1518X"	""	""	"RE1518X"	""	"HMR_3311"	"RCR14519"	""	0	""	""	"RE1518X;HMR_3311;MAR03311"
+"MAR02818"	""	"RE1519X;FAOXC101C102x"	""	""	""	"RE1519X;FAOXC101C102x"	""	""	""	""	0	""	""	"RE1519X;FAOXC101C102x;MAR04966"
 "MAR02820"	""	"RE1525C"	""	""	""	"RE1525C"	"MNXR103515"	""	""	""	0	""	""	"RE1525C"
 "MAR02826"	""	"RE1526C"	""	""	""	"RE1526C"	"MNXR103516"	""	""	""	0	""	""	"RE1526C"
 "MAR02828"	""	"RE1527C"	""	""	""	"RE1527C"	"MNXR103517"	""	""	""	0	""	""	"RE1527C"
@@ -8856,8 +8849,8 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR03271"	""	""	""	""	""	"RE2911C"	""	""	""	""	0	""	""	"RE2911C"
 "MAR03273"	""	"RE2912M"	""	""	""	"RE2912M"	""	""	""	""	0	""	""	"RE2912M"
 "MAR03274"	""	""	""	""	""	"RE2912X"	""	""	""	""	0	""	""	"RE2912X"
-"MAR03276"	""	""	""	""	""	"RE2913X"	""	""	""	""	0	""	""	"RE2913X"
-"MAR03289"	""	""	""	""	""	"RE2914X"	""	""	""	""	0	""	""	"RE2914X"
+"MAR03276"	""	""	"RE2913X"	""	""	"RE2913X"	""	"HMR_3364"	"RCR12576"	""	0	""	""	"RE2913X;HMR_3364;MAR03364"
+"MAR03289"	""	""	"RE2914X"	""	""	"RE2914X"	""	"HMR_3369"	"RCR12580"	""	0	""	""	"RE2914X;HMR_3369;MAR03369"
 "MAR03291"	""	""	""	""	""	"RE2915M"	""	""	""	""	0	""	""	"RE2915M"
 "MAR03295"	""	""	""	""	""	"RE2915X"	""	""	""	""	0	""	""	"RE2915X"
 "MAR03297"	""	""	""	""	""	"RE2921M"	""	""	""	""	0	""	""	"RE2921M"
@@ -9258,7 +9251,6 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR04943"	""	"EX_ivcrn_e"	""	""	""	"EX_ivcrn[e]"	"MNXR98685"	""	""	""	0	""	""	"EX_ivcrn[e]"
 "MAR04950"	""	"EX_tetdec2crn_e"	""	""	""	"EX_tetdec2crn[e]"	""	""	""	""	0	""	""	"EX_tetdec2crn[e]"
 "MAR04965"	""	"EX_tetdece1crn_e"	""	""	""	"EX_tetdece1crn[e]"	""	""	""	""	0	""	""	"EX_tetdece1crn[e]"
-"MAR04966"	""	"FAOXC101C102x"	""	""	""	"FAOXC101C102x"	""	""	""	""	0	""	""	"FAOXC101C102x"
 "MAR04967"	""	"FAOXC101C8m"	""	""	""	"FAOXC101C8m"	""	""	""	""	0	""	""	"FAOXC101C8m"
 "MAR04968"	""	"FAOXC101C8x"	""	""	""	"FAOXC101C8x"	""	""	""	""	0	""	""	"FAOXC101C8x"
 "MAR04970"	""	"FAOXC102C101m"	""	""	""	"FAOXC102C101m"	""	""	""	""	0	""	""	"FAOXC102C101m"
@@ -12975,3 +12967,4 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR20111"	"R00472"	""	""	""	""	""	"MNXR188337"	""	""	""	0	"RHEA:18182"	"RHEA:18181"	""
 "MAR20112"	"R04385"	""	""	""	""	""	"MNXR96330"	""	""	""	0	""	"RHEA:13501"	""
 "MAR20113"	""	""	""	""	""	""	""	""	""	""	0	""	""	""
+"MAR20114"	""	""	""	""	""	""	""	""	""	""	0	""	""	""