diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
index e9484f6b..d73fa814 100644
--- a/model/Human-GEM.yml
+++ b/model/Human-GEM.yml
@@ -71448,7 +71448,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000054179 or ENSG00000138185 or ENSG00000168032 or ENSG00000171302 or ENSG00000187097 or ENSG00000188833 or ENSG00000197217 or ENSG00000197586"
+      - gene_reaction_rule: "ENSG00000054179 or ENSG00000138185 or ENSG00000168032 or ENSG00000171302 or ENSG00000187097 or ENSG00000188833 or ENSG00000197586"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.6.1.5;3.6.1.6"
@@ -71465,7 +71465,7 @@
           - MAM02759c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000061918 and ENSG00000164116) or ENSG00000070019 or ENSG00000078295 or ENSG00000101890 or ENSG00000121281 or ENSG00000129467 or ENSG00000132518 or ENSG00000138031 or ENSG00000143199 or ENSG00000152402 or ENSG00000155897 or ENSG00000159899 or ENSG00000162104 or ENSG00000164742 or ENSG00000169418 or ENSG00000173175 or ENSG00000174233"
+      - gene_reaction_rule: "(ENSG00000061918 and ENSG00000164116) or ENSG00000078295 or ENSG00000121281 or ENSG00000129467 or ENSG00000138031 or ENSG00000143199 or ENSG00000155897 or ENSG00000159899 or ENSG00000162104 or ENSG00000164742 or ENSG00000173175 or ENSG00000174233"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "4.6.1.1;4.6.1.2"
@@ -71517,7 +71517,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
+      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000125458 or ENSG00000135318 or ENSG00000146587 or ENSG00000185013"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.5"
@@ -71535,7 +71535,7 @@
           - MAM02751e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
+      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.5"
@@ -71553,7 +71553,7 @@
           - MAM02751m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
+      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.5"
@@ -71590,7 +71590,7 @@
           - MAM02040c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000065989 or ENSG00000073417 or ENSG00000095464 or ENSG00000105650 or ENSG00000112541 or ENSG00000113231 or ENSG00000113448 or ENSG00000115252 or ENSG00000123360 or ENSG00000128655 or ENSG00000132915 or ENSG00000133256 or ENSG00000138735 or ENSG00000139053 or ENSG00000152270 or ENSG00000154678 or ENSG00000160191 or ENSG00000171408 or ENSG00000172572 or ENSG00000184588 or ENSG00000185527 or ENSG00000186642 or ENSG00000205268"
+      - gene_reaction_rule: "ENSG00000065989 or ENSG00000073417 or ENSG00000095464 or ENSG00000105650 or ENSG00000112541 or ENSG00000113231 or ENSG00000113448 or ENSG00000115252 or ENSG00000123360 or ENSG00000128655 or ENSG00000139053 or ENSG00000152270 or ENSG00000154678 or ENSG00000171408 or ENSG00000172572 or ENSG00000184588 or ENSG00000185527 or ENSG00000186642 or ENSG00000205268"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.4.17"
@@ -71625,7 +71625,7 @@
           - MAM02759c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000061918 and ENSG00000164116) or ENSG00000070019 or ENSG00000078295 or ENSG00000101890 or ENSG00000121281 or ENSG00000129467 or ENSG00000132518 or ENSG00000138031 or ENSG00000143199 or ENSG00000152402 or ENSG00000155897 or ENSG00000159899 or ENSG00000162104 or ENSG00000164742 or ENSG00000169418 or ENSG00000173175 or ENSG00000174233"
+      - gene_reaction_rule: "(ENSG00000061918 and ENSG00000164116) or ENSG00000070019 or ENSG00000078295 or ENSG00000101890 or ENSG00000121281 or ENSG00000132518 or ENSG00000138031 or ENSG00000143199 or ENSG00000152402 or ENSG00000155897 or ENSG00000159899 or ENSG00000169418"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "4.6.1.1;4.6.1.2"
@@ -71724,7 +71724,7 @@
           - MAM02040c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000065989 or ENSG00000073417 or ENSG00000095464 or ENSG00000105650 or ENSG00000112541 or ENSG00000113231 or ENSG00000113448 or ENSG00000115252 or ENSG00000123360 or ENSG00000128655 or ENSG00000132915 or ENSG00000133256 or ENSG00000138735 or ENSG00000139053 or ENSG00000152270 or ENSG00000154678 or ENSG00000160191 or ENSG00000171408 or ENSG00000172572 or ENSG00000184588 or ENSG00000185527 or ENSG00000186642 or ENSG00000205268"
+      - gene_reaction_rule: "ENSG00000073417 or ENSG00000095464 or ENSG00000112541 or ENSG00000113231 or ENSG00000113448 or ENSG00000115252 or ENSG00000123360 or ENSG00000128655 or ENSG00000132915 or ENSG00000133256 or ENSG00000138735 or ENSG00000139053 or ENSG00000152270 or ENSG00000154678 or ENSG00000160191 or ENSG00000171408 or ENSG00000172572 or ENSG00000185527 or ENSG00000186642"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.4.17;3.1.4.35"
@@ -71834,7 +71834,7 @@
           - MAM02759c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000125877"
+      - gene_reaction_rule: ""
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.6.1.19;3.6.1.8"
@@ -71927,7 +71927,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
+      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000125458 or ENSG00000135318 or ENSG00000146587 or ENSG00000185013"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.5"
@@ -72002,7 +72002,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
+      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000185013"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.5"
@@ -72020,7 +72020,7 @@
           - MAM02751e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
+      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.5"
@@ -72096,7 +72096,7 @@
           - MAM01639c: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000004455 or ENSG00000072778 or ENSG00000085231 or ENSG00000087008 or ENSG00000106992 or ENSG00000117054 or ENSG00000140057 or ENSG00000147853 or ENSG00000151498 or ENSG00000154027 or ENSG00000155085 or ENSG00000162433 or ENSG00000165695 or ENSG00000177646"
+      - gene_reaction_rule: "ENSG00000004455 or ENSG00000085231 or ENSG00000106992 or ENSG00000140057 or ENSG00000147853 or ENSG00000154027 or ENSG00000155085 or ENSG00000162433 or ENSG00000165695 or ENSG00000177646"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "2.7.4.11;2.7.4.3"
@@ -72265,7 +72265,7 @@
           - MAM02193c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000156510 or ENSG00000156515 or ENSG00000159399 or ENSG00000160883"
+      - gene_reaction_rule: "ENSG00000156515 or ENSG00000159399"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "2.7.1.1"
@@ -72284,7 +72284,7 @@
           - MAM02039c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000156510 or ENSG00000156515 or ENSG00000159399 or ENSG00000160883"
+      - gene_reaction_rule: "ENSG00000156510 or ENSG00000156515 or ENSG00000159399"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "2.7.1.1"
@@ -72415,7 +72415,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
+      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.5"
@@ -72603,7 +72603,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
+      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.5"
@@ -72789,7 +72789,7 @@
           - MAM03150c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013 or ENSG00000205309"
+      - gene_reaction_rule: "ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000135318 or ENSG00000141698 or ENSG00000146587 or ENSG00000185013"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.5"
@@ -72927,7 +72927,7 @@
           - MAM02872c: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000100354 or ENSG00000239900"
+      - gene_reaction_rule: "ENSG00000239900"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "4.3.2.2"
@@ -73038,7 +73038,7 @@
           - MAM03121e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000117592 or ENSG00000121053 or ENSG00000130508 or ENSG00000167419"
+      - gene_reaction_rule: "ENSG00000121053 or ENSG00000130508 or ENSG00000167419"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.11.1.7"
@@ -73257,7 +73257,7 @@
           - MAM01642c: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103024 or ENSG00000103202 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"
+      - gene_reaction_rule: "ENSG00000103024 or ENSG00000103202 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "2.7.4.6"
@@ -73275,7 +73275,7 @@
           - MAM02193c: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103024 or ENSG00000103202 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"
+      - gene_reaction_rule: "ENSG00000103024 or ENSG00000103202 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "2.7.4.6"
@@ -217612,7 +217612,7 @@
           - MAM03200l: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000014257 or ENSG00000102575 or ENSG00000134575 or ENSG00000162836"
+      - gene_reaction_rule: "ENSG00000014257 or ENSG00000102575 or ENSG00000134575"
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: "3.1.3.2"