diff --git a/st2common/st2common/services/sensor_watcher.py b/st2common/st2common/services/sensor_watcher.py
index 1c54881663..363d73ab3e 100644
--- a/st2common/st2common/services/sensor_watcher.py
+++ b/st2common/st2common/services/sensor_watcher.py
@@ -21,6 +21,7 @@
 
 import six
 from kombu.mixins import ConsumerMixin
+from oslo_config import cfg
 
 from st2common import log as logging
 from st2common.transport import reactor, publishers
@@ -126,7 +127,7 @@ def stop(self):
     @staticmethod
     def _get_queue(queue_suffix):
         queue_name = queue_utils.get_queue_name(
-            queue_name_base="st2.sensor.watch",
+            queue_name_base=f"{cfg.CONF.messaging.prefix}.sensor.watch",
             queue_name_suffix=queue_suffix,
             add_random_uuid_to_suffix=True,
         )
diff --git a/st2common/st2common/services/triggerwatcher.py b/st2common/st2common/services/triggerwatcher.py
index b82a46043a..698bcadeba 100644
--- a/st2common/st2common/services/triggerwatcher.py
+++ b/st2common/st2common/services/triggerwatcher.py
@@ -18,6 +18,7 @@
 
 import six
 from kombu.mixins import ConsumerMixin
+from oslo_config import cfg
 
 from st2common import log as logging
 from st2common.persistence.trigger import Trigger
@@ -163,7 +164,7 @@ def _load_triggers_from_db(self):
     @staticmethod
     def _get_queue(queue_suffix, exclusive):
         queue_name = queue_utils.get_queue_name(
-            queue_name_base="st2.trigger.watch",
+            queue_name_base=f"{cfg.CONF.messaging.prefix}.trigger.watch",
             queue_name_suffix=queue_suffix,
             add_random_uuid_to_suffix=True,
         )
diff --git a/st2reactor/st2reactor/container/sensor_wrapper.py b/st2reactor/st2reactor/container/sensor_wrapper.py
index cc4723043a..9fa8df1881 100644
--- a/st2reactor/st2reactor/container/sensor_wrapper.py
+++ b/st2reactor/st2reactor/container/sensor_wrapper.py
@@ -15,6 +15,8 @@
 
 from __future__ import absolute_import
 
+from st2common.transport.reactor import TRIGGER_CUD_XCHG, TRIGGER_INSTANCE_XCHG
+
 # Note: We need to perform monkey patching in the worker. If we do it in
 # the master process (gunicorn_config.py), it breaks tons of things
 # including shutdown
@@ -241,6 +243,12 @@ def __init__(
             ssl_match_hostname=cfg.CONF.database.ssl_match_hostname,
         )
 
+        # Apply prefix to RabbitMQ exchanges/queues (which are not bootstrapped in the wrapper)
+        prefix = cfg.CONF.messaging.prefix
+        if prefix != "st2":
+            for exchange in (TRIGGER_CUD_XCHG, TRIGGER_INSTANCE_XCHG):
+                exchange.name = exchange.name.replace("st2.", f"{prefix}.", 1)
+
         # 3. Instantiate the watcher
         self._trigger_watcher = TriggerWatcher(
             create_handler=self._handle_create_trigger,
diff --git a/tools/st2-inject-trigger-instances.py b/tools/st2-inject-trigger-instances.py
index 79b0f18e25..6af46c3b2f 100755
--- a/tools/st2-inject-trigger-instances.py
+++ b/tools/st2-inject-trigger-instances.py
@@ -37,7 +37,7 @@
 from st2common import config
 from st2common.util.monkey_patch import monkey_patch
 from st2common.util import date as date_utils
-from st2common.transport.reactor import TriggerDispatcher
+from st2common.transport.reactor import TRIGGER_INSTANCE_XCHG, TriggerDispatcher
 
 
 def do_register_cli_opts(opts, ignore_errors=False):
@@ -126,6 +126,12 @@ def main():
     do_register_cli_opts(cli_opts)
     config.parse_args()
 
+    # Apply prefix to RabbitMQ exchanges/queues (which have not been bootstrapped)
+    prefix = cfg.CONF.messaging.prefix
+    if prefix != "st2":
+        exchange = TRIGGER_INSTANCE_XCHG
+        exchange.name = exchange.name.replace("st2.", f"{prefix}.", 1)
+
     # Get config values
     triggers = cfg.CONF.triggers
     trigger_payload_schema = {}