diff --git a/Cargo.lock b/Cargo.lock
index f96d71a..a151ee5 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -103,9 +103,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.20.3"
+version = "0.21.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "53bdbb96d49157e65d45cc287af5f32ffadd5f4761438b527b055fb0d4bb8233"
+checksum = "a02a88a17e74cadbc8ce77855e1d6c8ad0ab82901a4a9b5046bd01c1c0bd95cd"
 dependencies = [
  "cfg-if",
  "indoc",
@@ -113,7 +113,7 @@ dependencies = [
  "memoffset",
  "parking_lot",
  "portable-atomic",
- "pyo3-build-config",
+ "pyo3-build-config 0.21.0",
  "pyo3-ffi",
  "pyo3-macros",
  "unindent",
@@ -129,21 +129,31 @@ dependencies = [
  "target-lexicon",
 ]
 
+[[package]]
+name = "pyo3-build-config"
+version = "0.21.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a5eb0b6ecba38961f6f4bd6cd5906dfab3cd426ff37b2eed5771006aa31656f1"
+dependencies = [
+ "once_cell",
+ "target-lexicon",
+]
+
 [[package]]
 name = "pyo3-ffi"
-version = "0.20.3"
+version = "0.21.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "62b42531d03e08d4ef1f6e85a2ed422eb678b8cd62b762e53891c05faf0d4afa"
+checksum = "ba8a6e48a29b5d22e4fdaf132d8ba8d3203ee9f06362d48f244346902a594ec3"
 dependencies = [
  "libc",
- "pyo3-build-config",
+ "pyo3-build-config 0.21.0",
 ]
 
 [[package]]
 name = "pyo3-macros"
-version = "0.20.3"
+version = "0.21.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7305c720fa01b8055ec95e484a6eca7a83c841267f0dd5280f0c8b8551d2c158"
+checksum = "4e80493c5965f94a747d0782a607b2328a4eea5391327b152b00e2f3b001cede"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
@@ -153,13 +163,13 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.20.3"
+version = "0.21.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7c7e9b68bb9c3149c5b0cade5d07f953d6d125eb4337723c4ccdb665f1f96185"
+checksum = "fcd7d86f42004025200e12a6a8119bd878329e6fddef8178eaafa4e4b5906c5b"
 dependencies = [
  "heck",
  "proc-macro2",
- "pyo3-build-config",
+ "pyo3-build-config 0.21.0",
  "quote",
  "syn",
 ]
@@ -199,7 +209,7 @@ name = "seahash-py"
 version = "0.2.0"
 dependencies = [
  "pyo3",
- "pyo3-build-config",
+ "pyo3-build-config 0.20.3",
  "seahash",
 ]
 
diff --git a/Cargo.toml b/Cargo.toml
index aed08c2..0096596 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -10,7 +10,7 @@ name = "seahash"
 crate-type = ["cdylib"]
 
 [dependencies]
-pyo3 = { version = "0.20.3", features = ["extension-module"] }
+pyo3 = { version = "0.21.0", features = ["extension-module"] }
 seahash = "4.1.0"
 
 [build-dependencies]