diff --git a/qiskit/transpiler/__init__.py b/qiskit/transpiler/__init__.py
index 1b3a3841e94..2fb0e83248f 100644
--- a/qiskit/transpiler/__init__.py
+++ b/qiskit/transpiler/__init__.py
@@ -107,11 +107,10 @@
 
     import numpy as np
     from qiskit.providers.fake_provider import GenericBackendV2
-    from qiskit.circuit.library import HGate, PhaseGate, RXGate, TdgGate, TGate, XGate
+    from qiskit.circuit.library import HGate, PhaseGate, RXGate, TdgGate, TGate, XGate, CXGate
     from qiskit.transpiler import PassManager, generate_preset_pass_manager
     from qiskit.transpiler.passes import (
         ALAPScheduleAnalysis,
-        CXCancellation,
         InverseCancellation,
         PadDynamicalDecoupling,
     )
@@ -132,7 +131,7 @@
     ]
     logical_opt = PassManager(
         [
-            CXCancellation(),
+            InverseCancellation([CXGate()]),
             InverseCancellation(inverse_gate_list),
         ]
     )
diff --git a/qiskit/transpiler/passes/__init__.py b/qiskit/transpiler/passes/__init__.py
index 948dea65018..8823e1ce723 100644
--- a/qiskit/transpiler/passes/__init__.py
+++ b/qiskit/transpiler/passes/__init__.py
@@ -75,7 +75,6 @@
    CollectLinearFunctions
    CollectCliffords
    ConsolidateBlocks
-   CXCancellation
    InverseCancellation
    CommutationAnalysis
    CommutativeCancellation
diff --git a/releasenotes/notes/remove_cxcancellation_11937-1d225c4331b7b4e2.yaml b/releasenotes/notes/remove_cxcancellation_11937-1d225c4331b7b4e2.yaml
new file mode 100644
index 00000000000..50788b2aeae
--- /dev/null
+++ b/releasenotes/notes/remove_cxcancellation_11937-1d225c4331b7b4e2.yaml
@@ -0,0 +1,6 @@
+---
+upgrade_transpiler:
+  - |
+    The pass ``qiskit.transpiler.passes.CXCancellation`` was removed. It was deprecated in favor of
+    class:`.InverseCancellation`, which is more generic.
+    ``CXCancellation`` is fully semantically equivalent to ``InverseCancellation([CXGate()])``.