Using non-harmonised versions and custom scores?

[scienception]

Is it ok to use the non-harmonized version of the PGS files? Or does pgs_calc expect exclusively this format?

I ask cause I developed my own PGS and don't have any info on hm_source, hm_rsID, hm_chr, hm_pos or hm_inferOtherAllele. Only on rsID, chr_name, chr_position, effect_allele, other_allele, effect_weight.

Will pgs_calc accept this format?

[nebfield]

You can use your own PGS by following this guide:

https://pgsc-calc.readthedocs.io/en/latest/how-to/calculate_custom.html#scorefile-setup

Your PGS scoring file needs a special header and some standard column names to be compatible