diff --git a/pcsx2/x86/ix86-32/iR5900.cpp b/pcsx2/x86/ix86-32/iR5900.cpp
index 75231334f3733..c08bb247de800 100644
--- a/pcsx2/x86/ix86-32/iR5900.cpp
+++ b/pcsx2/x86/ix86-32/iR5900.cpp
@@ -1707,7 +1707,7 @@ void recompileNextInstruction(bool delayslot, bool swapped_delay_slot)
 	g_pCurInstInfo++;
 
 	// pc might be past s_nEndBlock if the last instruction in the block is a DI.
-	if (pc <= s_nEndBlock)
+	if (pc <= s_nEndBlock && (g_pCurInstInfo + (s_nEndBlock - pc) / 4 + 1) <= s_pInstCache + s_nInstCacheSize)
 	{
 		int count;
 		for (u32 i = 0; i < iREGCNT_GPR; ++i)