diff --git a/gufe/components/explicitmoleculecomponent.py b/gufe/components/explicitmoleculecomponent.py
index fe5e7c59..dc8d80b0 100644
--- a/gufe/components/explicitmoleculecomponent.py
+++ b/gufe/components/explicitmoleculecomponent.py
@@ -9,6 +9,10 @@
 # typing
 from ..custom_typing import RDKitMol
 
+# globally set RDKit to include all properties when pickling an RDKit Mol
+# see issue #322: https://github.com/OpenFreeEnergy/gufe/issues/322
+Chem.SetDefaultPickleProperties(Chem.PropertyPickleOptions.AllProps)
+
 
 def _ensure_ofe_name(mol: RDKitMol, name: str) -> str:
     """