diff --git a/neo/rawio/biocamrawio.py b/neo/rawio/biocamrawio.py
index d61d92daee..80400e5473 100644
--- a/neo/rawio/biocamrawio.py
+++ b/neo/rawio/biocamrawio.py
@@ -4,7 +4,7 @@
 See:
 https://www.3brain.com/products/single-well/biocam-x
 
-Author : Alessio Buccino
+Authors: Alessio Buccino, Robert Wolff, Baptiste Grimaud
 """
 
 from .baserawio import (BaseRawIO, _signal_channel_dtype, _signal_stream_dtype,
@@ -145,14 +145,14 @@ def open_biocam_file_header(filename):
     if format_100:
         if signal_inv == 1:
             read_function = readHDF5t_100
-        elif signal_inv == 1:
+        elif signal_inv == -1:
             read_function = readHDF5t_100_i
         else:
             raise Exception("Unknown signal inversion")
     else:
         if signal_inv == 1:
             read_function = readHDF5t_101
-        elif signal_inv == 1:
+        elif signal_inv == -1:
             read_function = readHDF5t_101_i
         else:
             raise Exception("Unknown signal inversion")
@@ -166,16 +166,16 @@ def open_biocam_file_header(filename):
 
 
 def readHDF5t_100(rf, t0, t1, nch):
-    return rf['3BData/Raw'][t0:t1]
+    return rf['3BData/Raw'][t0:t1].astype(np.int16) - 2048
 
 
 def readHDF5t_100_i(rf, t0, t1, nch):
-    return 4096 - rf['3BData/Raw'][t0:t1]
+    return 2048 - rf['3BData/Raw'][t0:t1].astype(np.int16)
 
 
 def readHDF5t_101(rf, t0, t1, nch):
-    return rf['3BData/Raw'][nch * t0:nch * t1].reshape((t1 - t0, nch), order='C')
+    return rf['3BData/Raw'][nch * t0:nch * t1].reshape((t1 - t0, nch), order='C').astype(np.int16) - 2048
 
 
 def readHDF5t_101_i(rf, t0, t1, nch):
-    return 4096 - rf['3BData/Raw'][nch * t0:nch * t1].reshape((t1 - t0, nch), order='C')
+    return 2048 - rf['3BData/Raw'][nch * t0:nch * t1].reshape((t1 - t0, nch), order='C').astype(np.int16)