From 9c61f4fd709e4b7da1875d21a0dab9689ee0aa27 Mon Sep 17 00:00:00 2001 From: wulfdewolf Date: Tue, 13 Feb 2024 13:40:59 +0000 Subject: [PATCH] paper abbrs --- _bibliography/convert.py | 19 + _bibliography/nolan.bib | 84 - _bibliography/papers.bib | 5182 +++++++++++++++++++------------------- 3 files changed, 2630 insertions(+), 2655 deletions(-) create mode 100644 _bibliography/convert.py delete mode 100644 _bibliography/nolan.bib diff --git a/_bibliography/convert.py b/_bibliography/convert.py new file mode 100644 index 000000000000..5a3bd739308e --- /dev/null +++ b/_bibliography/convert.py @@ -0,0 +1,19 @@ + +import bibtexparser + + +def add_field_if_author_in_entry(bibtex_path, author_name, new_field, new_field_value): + with open(bibtex_path) as bibtex_file: + bib_database = bibtexparser.load(bibtex_file) + + for entry in bib_database.entries: + if 'author' in entry and author_name in entry['author']: + entry[new_field] = new_field_value + + with open(bibtex_path, 'w') as bibtex_file: + bibtexparser.dump(bib_database, bibtex_file) + + +# Usage +add_field_if_author_in_entry( + 'papers.bib', 'Nolan', 'abbr', 'NOLAN') diff --git a/_bibliography/nolan.bib b/_bibliography/nolan.bib deleted file mode 100644 index ce201ffac77e..000000000000 --- a/_bibliography/nolan.bib +++ /dev/null @@ -1,84 +0,0 @@ ---- ---- - -@string{aps = {American Physical Society,}} - -@book{einstein1956investigations, - bibtex_show={true}, - title={Investigations on the Theory of the Brownian Movement}, - author={Einstein, Albert}, - year={1956}, - publisher={Courier Corporation}, - preview={brownian-motion.gif} -} - -@article{einstein1950meaning, - abbr={AJP}, - bibtex_show={true}, - title={The meaning of relativity}, - author={Einstein, Albert and Taub, AH}, - journal={American Journal of Physics}, - volume={18}, - number={6}, - pages={403--404}, - year={1950}, - publisher={American Association of Physics Teachers} -} - -@article{PhysRev.47.777, - abbr={PhysRev}, - title={Can Quantum-Mechanical Description of Physical Reality Be Considered Complete?}, - author={Einstein, A. and Podolsky, B. and Rosen, N.}, - abstract={In a complete theory there is an element corresponding to each element of reality. A sufficient condition for the reality of a physical quantity is the possibility of predicting it with certainty, without disturbing the system. In quantum mechanics in the case of two physical quantities described by non-commuting operators, the knowledge of one precludes the knowledge of the other. Then either (1) the description of reality given by the wave function in quantum mechanics is not complete or (2) these two quantities cannot have simultaneous reality. Consideration of the problem of making predictions concerning a system on the basis of measurements made on another system that had previously interacted with it leads to the result that if (1) is false then (2) is also false. One is thus led to conclude that the description of reality as given by a wave function is not complete.}, - journal={Phys. Rev.}, - volume={47}, - issue={10}, - pages={777--780}, - numpages={0}, - year={1935}, - month={May}, - publisher=aps, - doi={10.1103/PhysRev.47.777}, - url={http://link.aps.org/doi/10.1103/PhysRev.47.777}, - html={https://journals.aps.org/pr/abstract/10.1103/PhysRev.47.777}, - pdf={example_pdf.pdf}, - altmetric={248277}, - dimensions={true}, - selected={true} -} - -@article{einstein1905molekularkinetischen, - title={{\"U}ber die von der molekularkinetischen Theorie der W{\"a}rme geforderte Bewegung von in ruhenden Fl{\"u}ssigkeiten suspendierten Teilchen}, - author={Einstein, A.}, - journal={Annalen der physik}, - volume={322}, - number={8}, - pages={549--560}, - year={1905}, - publisher={Wiley Online Library} -} - -@article{einstein1905movement, - abbr={Ann. Phys.}, - title={Un the movement of small particles suspended in statiunary liquids required by the molecular-kinetic theory 0f heat}, - author={Einstein, A.}, - journal={Ann. Phys.}, - volume={17}, - pages={549--560}, - year={1905} -} - -@article{einstein1905electrodynamics, - title={On the electrodynamics of moving bodies}, - author={Einstein, A.}, - year={1905} -} - -@book{przibram1967letters, - bibtex_show={true}, - title={Letters on wave mechanics}, - author={Einstein, Albert and Schrödinger, Erwin and Planck, Max and Lorentz, Hendrik Antoon and Przibram, Karl}, - year={1967}, - publisher={Vision}, - preview={wave-mechanics.gif} -} diff --git a/_bibliography/papers.bib b/_bibliography/papers.bib index 2686f8edb988..2b9ce3eca7e1 100644 --- a/_bibliography/papers.bib +++ b/_bibliography/papers.bib @@ -1,369 +1,401 @@ - -@article{WOS:000303126700001, - author = {Pastoll, Hugh and Ramsden, Helen L. and Nolan, Matthew F.}, - title = {Intrinsic electrophysiological properties of entorhinal cortex stellate - cells and their contribution to grid cell firing fields}, - journal = {FRONTIERS IN NEURAL CIRCUITS}, - year = {2012}, - volume = {6}, - month = {APR 24}, - abstract = {The medial entorhinal contex (MEC) is an increasingly important focus - for investigation of mechanisms for spatial representation. Grid cells - found in layer II of the MEC are likely to be stellate cells, which form - a major projection to the dentate gyrus. Entorhinal stellate cells are - distinguished by distinct intrinsic electrophysiological properties, but - how these properties contribute to representation of space is not yet - clear. Here, we review the ionic conductances, synaptic, and excitable - properties of stellate cells, and examine thier implication for models - of grid firing fields. We discuss why existing data are inconsistent - with models of grid fields that require stellate cells to generate - periodic oscillation. An alternate possibility is that the intrinsic - electrophysiological properties of stellate cells are tuned specifically - to control integration of synaptic input. We highlight recent evidence - that the dorsal-ventra; organization of synaptic integraiton by stellate - cells, through differences in currents mediated by HCN and leak - potassium channels, influences the corresponding organization of grid - fields. Because accurate cellular data will be important for - distinguishing mechanisms for generation of grid fields, we introduce - new date comparing properties measured with whole-cell and perforated - patch-clamp recordings. We find that clustered patterns of action - potential firing and the action potential after-hyperpolarization (AHP) - are particularly sensitive to recording condition. Neverthless, with - both methods, these properties, resting membrane properties and - resonance follow a dorsal-ventral organization. Further investigation of - the molecular basis for synaptic integration by stellate cells will be - important for understanding mechanisms for generation of grid fields.}, - publisher = {FRONTIERS MEDIA SA}, +@article{WOS:000209370100006, + abbr = {NOLAN}, + abstract = {We introduce a molecular toolbox for manipulation of neuronal gene + expression in vivo. The toolbox includes promoters, ion channels, + optogenetic tools, fluorescent proteins, and intronic artificial + microRNAs. The components are easily assembled into adeno-associated + virus (AAV) or lentivirus vectors using recombination cloning. We + demonstrate assembly of toolbox components into lentivirus and AAV + vectors and use these vectors for in vivo expression of inwardly + rectifying potassium channels (Kir2.1, Kir3.1, and Kir3.2) and an + artificial microRNA targeted against the ion channel HCN1 (HCN1 miRNA). + We show that AAV assembled to express HCN1 miRNA produces efficacious + and specific in vivo knockdown of HCN1 channels. Comparison of in vivo + viral transduction using HCN1 miRNA with mice containing a germ line + deletion of HCN1 reveals similar physiological phenotypes in cerebellar + Purkinje cells. The easy assembly and re-usability of the toolbox + components, together with the ability to up- or down-regulate neuronal + gene expression in vivo, may be useful for applications in many areas of + neuroscience.}, address = {AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND}, - type = {Article}, - language = {English}, affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. - Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. - Pastoll, Hugh; Ramsden, Helen L., Univ Edinburgh, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.3389/fncir.2012.00017}, - article-number = {1}, - issn = {1662-5110}, - keywords = {ion channel; grid cell; HCN; synaptic integration; oscillation; theta; - resonance}, - keywords-plus = {LAYER-II STELLATE; INHIBITS NEURONAL EXCITABILITY; VOLTAGE-DEPENDENT - INACTIVATION; ACTIVATED CATION CURRENTS; SUSTAINED SODIUM CURRENT; - PERSISTENT NA+ CURRENT; SUBTHRESHOLD OSCILLATIONS; PYRAMIDAL NEURONS; - THETA-RHYTHM; IONIC MECHANISMS}, + White, Melanie D.; Milne, Ruth V. J.; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh}, + article-number = {8}, + author = {White, Melanie D. and Milne, Ruth V. J. and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {V38VE}, + doi = {10.3389/fnmol.2011.00008}, + funding-acknowledgement = {Marie Curie Excellence Grant; BBSRC; MRC; NARSAD; BBSRC {[}BB/H020284/1] + Funding Source: UKRI; MRC {[}G0501216] Funding Source: UKRI; + Biotechnology and Biological Sciences Research Council {[}BB/H020284/1] + Funding Source: researchfish; Medical Research Council {[}G0501216] + Funding Source: researchfish}, + funding-text = {We thank Trudi Gillespi from the IMPACT Imaging facility at the + University of Edinburgh for assistance with confocal microscopy and Bina + Santoro, Hiroyuki Hioki, Patrick Martin, Axel Schambach, and Guangwei Du + for generously providing plasmids. This work was funded by a Marie Curie + Excellence Grant and grants from the BBSRC, the MRC, and NARSAD.}, + issn = {1662-5099}, + journal = {FRONTIERS IN MOLECULAR NEUROSCIENCE}, + journal-iso = {Front. Molec. Neurosci.}, + keywords = {intronic miRNA; ion channel; lentivirus; AAV; RNAi; hippocampus; + cerebellum; virus}, + keywords-plus = {LENTIVIRAL VECTORS; HCN1 CHANNELS; HOMOLOGOUS RECOMBINATION; + ADENOASSOCIATED VIRUS; TRANSGENE EXPRESSION; CORTICAL-NEURONS; RNA + INTERFERENCE; DNA CLONING; PROTEIN; BRAIN}, + language = {English}, + number-of-cited-references = {49}, + oa = {Green Published, gold}, + orcid-numbers = {White, Melanie/0000-0002-7399-8348 + Nolan, Matthew F/0000-0003-1062-6501}, + publisher = {FRONTIERS MEDIA SA}, research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {White, Melanie/J-5565-2019 + White, Melanie/IAR-3760-2023 + Nolan, Matthew F/A-1356-2009}, + times-cited = {30}, + title = {A molecular toolbox for rapid generation of viral vectors to up- or + down-regulate neuronal gene expression in vivo}, + type = {Article}, + unique-id = {WOS:000209370100006}, + usage-count-last-180-days = {0}, + usage-count-since-2013 = {5}, + volume = {4}, web-of-science-categories = {Neurosciences}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009}, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501}, - funding-acknowledgement = {Biotechnology and Biological Sciences Research Council; Engineering and - Physical Sciences Research Council; Commonwealth Scholarships - Commission; BBSRC {[}BB/H020284/1] Funding Source: UKRI}, - funding-text = {This work was supported by the Biotechnology and Biological Sciences - Research Council (Matthew F. Nolan), the Engineering and Physical - Sciences Research Council (Hugh Pastoll and Helen Ramsden) and the - Commonwealth Scholarships Commission (Hugh Pastoll).}, - number-of-cited-references = {135}, - times-cited = {45}, - usage-count-last-180-days = {1}, - usage-count-since-2013 = {12}, - journal-iso = {Front. Neural Circuits}, - doc-delivery-number = {930GW}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000303126700001}, - oa = {Green Published, gold}, - da = {2024-02-13} + year = {2011} } -@article{WOS:000519942200001, - author = {Pastoll, Hugh and Garden, Derek L. and Papastathopoulos, Ioannis and - Surmeli, Gulden and Nolan, Matthew F.}, - title = {Inter- and intra-animal variation in the integrative properties of - stellate cells in the medial entorhinal cortex}, - journal = {ELIFE}, - year = {2020}, - volume = {9}, - month = {FEB 13}, - abstract = {Distinctions between cell types underpin organizational principles for - nervous system function. Functional variation also exists between - neurons of the same type. This is exemplified by correspondence between - grid cell spatial scales and the synaptic integrative properties of - stellate cells (SCs) in the medial entorhinal cortex. However, we know - little about how functional variability is structured either within or - between individuals. Using ex-vivo patch-clamp recordings from up to 55 - SCs per mouse, we found that integrative properties vary between mice - and, in contrast to the modularity of grid cell spatial scales, have a - continuous dorsoventral organization. Our results constrain mechanisms - for modular grid firing and provide evidence for inter-animal phenotypic - variability among neurons of the same type. We suggest that neuron type - properties are tuned to circuit-level set points that vary within and - between animals.}, - publisher = {eLIFE SCIENCES PUBL LTD}, - address = {SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND}, - type = {Article}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland. - Pastoll, Hugh; Garden, Derek L.; Surmeli, Gulden; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland. - Papastathopoulos, Ioannis, Alan Turing Inst, London, England. - Papastathopoulos, Ioannis, Univ Edinburgh, Maxwell Inst, Sch Math, Edinburgh, Midlothian, Scotland. - Papastathopoulos, Ioannis, Univ Edinburgh, Ctr Stat, Edinburgh, Midlothian, Scotland.}, - doi = {10.7554/eLife.52258}, - article-number = {e52258}, - issn = {2050-084X}, - keywords-plus = {GRID CELLS; HCN1 CHANNELS; LAYER-II; NEURONS; MODEL; DORSAL; THETA; - OSCILLATIONS; FREQUENCY; ORGANIZATION}, - research-areas = {Life Sciences \& Biomedicine - Other Topics}, - web-of-science-categories = {Biology}, +@article{WOS:000250952700003, + abbr = {NOLAN}, + abstract = {Whereas recent studies have elucidated principles for representation of + information within the entorhinal cortex, less is known about the + molecular basis for information processing by entorhinal neurons. The + HCN1 gene encodes ion channels that mediate hyperpolarization-activated + currents (I-h) that control synaptic integration and influence several + forms of learning and memory. We asked whether + hyperpolarization-activated, cation nonselective 1 (HCN1) channels + control processing of information by stellate cells found within layer + II of the entorhinal cortex. Axonal projections from these neurons form + a major component of the synaptic input to the dentate gyrus of the + hippocampus. To determine whether HCN1 channels control either the + resting or the active properties of stellate neurons, we performed + whole-cell recordings in horizontal brain slices prepared from adult + wild-type and HCN1 knock-out mice. We found that HCN1 channels are + required for rapid and full activation of hyperpolarization-activated + currents in stellate neurons. HCN1 channels dominate the membrane + conductance at rest, are not required for theta frequency (4-12 Hz) + membrane potential fluctuations, but suppress low-frequency (< 4 Hz) + components of spontaneous and evoked membrane potential activity. During + sustained activation of stellate cells sufficient for firing of repeated + action potentials, HCN1 channels control the pattern of spike output by + promoting recovery of the spike afterhyperpolarization. These data + suggest that HCN1 channels expressed by stellate neurons in layer II of + the entorhinal cortex are key molecular components in the processing of + inputs to the hippocampal dentate gyrus, with distinct integrative roles + during resting and active states.}, + address = {11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Neurosci Res \& Vet Biomed Sci, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. + Univ Edinburgh, Ctr Neurosci Res \& Vet Biomed Sci, Edinburgh EH8 9XD, Midlothian, Scotland. + Columbia Univ, Ctr Neurobiol \& Behav, New York, NY 10032 USA.}, + affiliations = {University of Edinburgh; Columbia University}, + author = {Nolan, Matthew F. and Dudman, Joshua T. and Dodson, Paul D. and Santoro, + Bina}, author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; Heriot Watt University; University of - Edinburgh; University of Edinburgh}, + da = {2024-02-13}, + doc-delivery-number = {231NA}, + doi = {10.1523/JNEUROSCI.2358-07.2007}, + eissn = {1529-2401}, + funding-acknowledgement = {Medical Research Council {[}G0501216] Funding Source: Medline; NINDS NIH + HHS {[}R56 NS036658, NS36658, R01 NS036658] Funding Source: Medline; + Medical Research Council {[}G0501216] Funding Source: researchfish; MRC + {[}G0501216] Funding Source: UKRI}, + issn = {0270-6474}, + journal = {JOURNAL OF NEUROSCIENCE}, + journal-iso = {J. Neurosci.}, + keywords = {parahippocampal cortex; voltage; gated ion channels; neuronal + excitability; spatial memory; I-h; epilepsy}, + keywords-plus = {SUBTHRESHOLD OSCILLATIONS; DIFFERENTIAL ELECTRORESPONSIVENESS; SPATIAL + REPRESENTATION; DENDRITIC INTEGRATION; PYRAMIDAL NEURONS; IONIC + MECHANISMS; CATION CURRENTS; PERFORANT PATH; H-CHANNEL; RAT}, + language = {English}, + month = {NOV 14}, + number = {46}, + number-of-cited-references = {62}, + oa = {Green Published, hybrid}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Dodson, Paul/0000-0003-0858-6088 + Santoro, Bina/0000-0002-4277-1992}, + pages = {12440-12451}, + publisher = {SOC NEUROSCIENCE}, + research-areas = {Neurosciences \& Neurology}, researcherid-numbers = {Nolan, Matthew F/A-1356-2009 }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - SURMELI, GULSEN/0000-0002-3227-0641 - Garden, Derek/0000-0003-3336-3791}, - funding-acknowledgement = {Biotechnology and Biological Sciences Research Council (BBSRC) - {[}200855/Z/16/Z, BB/1022147/1]; Biotechnology and Biological Sciences - Research Council {[}BB/H020284/1]; Wellcome {[}200855/Z/16/Z]; BBSRC - {[}BB/L010496/1, BB/H020284/1, BB/I022147/1] Funding Source: UKRI; - Wellcome Trust {[}200855/Z/16/Z] Funding Source: Wellcome Trust}, - funding-text = {Biotechnology and Biological Sciences Research Council (BBSRC) - 200855/Z/16/Z Matthew F Nolan; Biotechnology and Biological Sciences - Research Council (BBSRC) BB/1022147/1 Matthew F Nolan; Biotechnology and - Biological Sciences Research Council BB/H020284/1 Matthew F Nolan; - Wellcome 200855/Z/16/Z Matthew F Nolan; The funders had no role in study - design, data collection and interpretation, or the decision to submit - the work for publication.}, - number-of-cited-references = {84}, - times-cited = {12}, + times-cited = {146}, + title = {HCN1 channels control resting and active integrative properties of + stellate cells from layer II of the entorhinal cortex}, + type = {Article}, + unique-id = {WOS:000250952700003}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {6}, - journal-iso = {eLife}, - doc-delivery-number = {KU8DN}, - web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)}, - unique-id = {WOS:000519942200001}, - oa = {Green Submitted, gold, Green Published}, - da = {2024-02-13} -} - -@article{WOS:000393396400001, - author = {Chadwick, Angus and van Rossum, Mark C. W. and Nolan, Matthew F.}, - title = {Flexible theta sequence compression mediated via phase precessing - interneurons}, - journal = {ELIFE}, - year = {2016}, - volume = {5}, - month = {DEC 8}, - abstract = {Encoding of behavioral episodes as spike sequences during hippocampal - theta oscillations provides a neural substrate for computations on - events extended across time and space. However, the mechanisms - underlying the numerous and diverse experimentally observed properties - of theta sequences remain poorly understood. Here we account for theta - sequences using a novel model constrained by the septo-hippocampal - circuitry. We show that when spontaneously active interneurons integrate - spatial signals and theta frequency pacemaker inputs, they generate - phase precessing action potentials that can coordinate theta sequences - in place cell populations. We reveal novel constraints on sequence - generation, predict cellular properties and neural dynamics that - characterize sequence compression, identify circuit organization - principles for high capacity sequential representation, and show that - theta sequences can be used as substrates for association of conditioned - stimuli with recent and upcoming events. Our results suggest mechanisms - for flexible sequence compression that are suited to associative - learning across an animals lifespan.}, - publisher = {ELIFE SCIENCES PUBLICATIONS LTD}, - address = {SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND}, - type = {Article}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. - Chadwick, Angus; van Rossum, Mark C. W., Univ Edinburgh, Inst Adapt \& Neural Computat, Sch Informat, Edinburgh EH8 9YL, Midlothian, Scotland. - Chadwick, Angus, Univ Edinburgh, Neuroinformat Doctoral Training Ctr, Sch Informat, Edinburgh, Midlothian, Scotland. - Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland.}, - doi = {10.7554/eLife.20349}, - article-number = {e20349}, - issn = {2050-084X}, - keywords-plus = {HIPPOCAMPAL PLACE CELLS; CA1 PYRAMIDAL NEURONS; OSCILLATORY - INTERFERENCE; SEPTOTEMPORAL AXIS; VIRTUAL NAVIGATION; RAT HIPPOCAMPUS; - TEMPORAL CODE; GRID CELLS; DYNAMICS; NETWORK}, - research-areas = {Life Sciences \& Biomedicine - Other Topics}, - web-of-science-categories = {Biology}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh; University of - Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Chadwick, Angus/0000-0003-2664-0746 - van Rossum, Mark CW/0000-0001-6525-6814}, - funding-acknowledgement = {Engineering and Physical Sciences Research Council {[}EP/F500385/1]; - Biotechnology and Biological Sciences Research Council {[}BB/L010496/1]; - Biotechnology and Biological Sciences Research Council {[}BB/L010496/1] - Funding Source: researchfish; BBSRC {[}BB/L010496/1] Funding Source: - UKRI}, - funding-text = {Engineering and Physical Sciences Research Council EP/F500385/1 Angus - Chadwick Mark CW van Rossum; Biotechnology and Biological Sciences - Research Council BB/L010496/1 Matthew F Nolan; The funders had no role - in study design, data collection and interpretation, or the decision to - submit the work for publication.}, - number-of-cited-references = {79}, - times-cited = {10}, - usage-count-last-180-days = {0}, - usage-count-since-2013 = {6}, - journal-iso = {eLife}, - doc-delivery-number = {EJ7IY}, + usage-count-since-2013 = {16}, + volume = {27}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000393396400001}, - oa = {gold, Green Submitted, Green Published, Green Accepted}, - da = {2024-02-13} + year = {2007} } -@article{WOS:000358250400001, - author = {Solanka, Lukas and van Rossum, Mark C. W. and Nolan, Matthew F.}, - title = {Noise promotes independent control of gamma oscillations and grid firing - within recurrent attractor networks}, - journal = {ELIFE}, - year = {2015}, - volume = {4}, - month = {JUL 6}, - abstract = {Neural computations underlying cognitive functions require calibration - of the strength of excitatory and inhibitory synaptic connections and - are associated with modulation of gamma frequency oscillations in - network activity. However, principles relating gamma oscillations, - synaptic strength and circuit computations are unclear. We address this - in attractor network models that account for grid firing and - theta-nested gamma oscillations in the medial entorhinal cortex. We show - that moderate intrinsic noise massively increases the range of synaptic - strengths supporting gamma oscillations and grid computation. With - moderate noise, variation in excitatory or inhibitory synaptic strength - tunes the amplitude and frequency of gamma activity without disrupting - grid firing. This beneficial role for noise results from disruption of - epileptic-like network states. Thus, moderate noise promotes independent - control of multiplexed firing rate-and gamma-based computational - mechanisms. Our results have implications for tuning of normal circuit - function and for disorders associated with changes in gamma oscillations - and synaptic strength.}, - publisher = {ELIFE SCIENCES PUBLICATIONS LTD}, - address = {SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND}, - type = {Article}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. - Solanka, Lukas; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. - Solanka, Lukas; van Rossum, Mark C. W., Inst Adapt \& Neural Computat, Edinburgh, Midlothian, Scotland. - Solanka, Lukas, Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Edinburgh, Midlothian, Scotland.}, - doi = {10.7554/eLife.06444}, - article-number = {e06444}, - issn = {2050-084X}, - keywords-plus = {ENTORHINAL CORTEX; PARVALBUMIN INTERNEURONS; LAYER-II; MODEL; - MECHANISMS; DYNAMICS; MEMORY; CELLS; RAT; REPRESENTATION}, - research-areas = {Life Sciences \& Biomedicine - Other Topics}, - web-of-science-categories = {Biology}, - author-email = {mattnolan@ed.ac.uk}, +@article{WOS:000261746700017, + abbr = {NOLAN}, + abstract = {Neurons important for cognitive function are often classified by their + morphology and integrative properties. However, it is unclear if within + a single class of neuron these properties tune synaptic responses to the + salient features of the information that each neuron represents. We + demonstrate that for stellate neurons in layer 11 of the medial + entorhinal cortex, the waveform of postsynaptic potentials, the time + window for detection of coincident inputs, and responsiveness to gamma + frequency inputs follow a dorsal-ventral gradient similar to the + topographical organization of grid-like spatial firing fields of neurons + in this area. We provide evidence that these differences are due to a + membrane conductance gradient mediated by HCN and leak potassium + channels. These findings suggest key roles for synaptic integration in + computations carried out within the medial entorhinal cortex and imply + that tuning of neural information processing by membrane ion channels is + important for normal cognitive function.}, + address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Res Neurosci, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. + Garden, Derek L. F.; Dodson, Paul D.; O'Donnell, Cian; White, Melanie D.; Nolan, Matthew F., Univ Edinburgh, Ctr Res Neurosci, Edinburgh EH8 9XD, Midlothian, Scotland. + Garden, Derek L. F.; Dodson, Paul D.; O'Donnell, Cian; White, Melanie D.; Nolan, Matthew F., Univ Edinburgh, RDSVS, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. + O'Donnell, Cian, Univ Edinburgh, Sch Informat, Inst Adapt \& Neural Computat, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9AB, Midlothian, Scotland.}, affiliations = {University of Edinburgh; University of Edinburgh; University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + author = {Garden, Derek L. F. and Dodson, Paul D. and O'Donnell, Cian and White, + Melanie D. and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {384LQ}, + doi = {10.1016/j.neuron.2008.10.044}, + eissn = {1097-4199}, + funding-acknowledgement = {Medical Research Council; Marie Curie Excellence; European Neuroscience + Institutes (ENI-NET); Human Frontier Science Program; EPSRC; Medical + Research Council {[}G0501216] Funding Source: researchfish; MRC + {[}G0501216] Funding Source: UKRI}, + funding-text = {We thank Mayank Dutia and Stephen Williams for comments on an earlier + version of the manuscript, Gareth Leng for statistical advice, and + Jessie vanBinsbergen and Michelle Lew for assistance with + reconstructions. This work was supported by the Medical Research Council + (M.F.N. and C.O'D.), a Marie Curie Excellence grant (M.F.N.), the + network of European Neuroscience Institutes (ENI-NET), a Human Frontier + Science Program long-term fellowship (P.D.D.), and the EPSRC (C.O'D.).}, + issn = {0896-6273}, + journal = {NEURON}, + journal-iso = {Neuron}, + keywords-plus = {UNION-OF-PHARMACOLOGY; LAYER-II; SUBTHRESHOLD OSCILLATIONS; MOLECULAR + RELATIONSHIPS; HIPPOCAMPAL-FORMATION; POTASSIUM CHANNELS; STELLATE + CELLS; NEURONS; RAT; PROJECTION}, + language = {English}, + month = {DEC 11}, + number = {5}, + number-of-cited-references = {52}, + oa = {Green Submitted, hybrid}, + orcid-numbers = {White, Melanie/0000-0002-7399-8348 + Garden, Derek/0000-0003-3336-3791 + Nolan, Matthew F/0000-0003-1062-6501 + O'Donnell, Cian/0000-0003-2031-9177 + Dodson, Paul/0000-0003-0858-6088}, + pages = {875-889}, + publisher = {CELL PRESS}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {White, Melanie/J-5565-2019 + Garden, Derek/AAB-5908-2020 + White, Melanie/IAR-3760-2023 + Nolan, Matthew F/A-1356-2009 }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - van Rossum, Mark CW/0000-0001-6525-6814}, - funding-acknowledgement = {Biotechnology and Biological Sciences Research Council (BBSRC) - {[}BB/L010496/1, BB/F529254/1]; Engineering and Physical Sciences - Research Council (EPSRC) {[}EP/F500385/1]; BBSRC {[}BB/F529254/1, - BB/L010496/1] Funding Source: UKRI; Biotechnology and Biological - Sciences Research Council {[}BB/L010496/1] Funding Source: researchfish}, - funding-text = {Biotechnology and Biological Sciences Research Council (BBSRC) - BB/L010496/1 Lukas Solanka, Matthew F Nolan; Biotechnology and - Biological Sciences Research Council (BBSRC) BB/F529254/1 Lukas Solanka, - Mark CW van Rossum; Engineering and Physical Sciences Research Council - (EPSRC) EP/F500385/1 Lukas Solanka, Mark CW van Rossum}, - number-of-cited-references = {54}, - times-cited = {16}, + times-cited = {130}, + title = {Tuning of Synaptic Integration in the Medial Entorhinal Cortex to the + Organization of Grid Cell Firing Fields}, + type = {Article}, + unique-id = {WOS:000261746700017}, usage-count-last-180-days = {0}, usage-count-since-2013 = {9}, - journal-iso = {eLife}, - doc-delivery-number = {CN2KR}, + volume = {60}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000358250400001}, - oa = {Green Submitted, Green Published, gold}, - da = {2024-02-13} + year = {2008} } -@article{WOS:000413916800007, - author = {Schmidt-Hieber, Christoph and Nolan, Matthew F.}, - title = {Synaptic integrative mechanisms for spatial cognition}, - journal = {NATURE NEUROSCIENCE}, - year = {2017}, - volume = {20}, - number = {11}, - pages = {1483-1492}, - month = {NOV}, - abstract = {Synaptic integrative mechanisms have profound effects on electrical - signaling in the brain that, although largely hidden from recording - methods that observe the spiking activity of neurons, may be critical - for the encoding, storage and retrieval of information. Here we review - roles for synaptic integrative mechanisms in the selection, generation - and plasticity of place and grid fields, and in related temporal codes - for the representation of space. We outline outstanding questions and - challenges in the testing of hypothesized models for spatial computation - and memory.}, - publisher = {NATURE PORTFOLIO}, - address = {HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY}, - type = {Review}, - language = {English}, - affiliation = {Schmidt-Hieber, C (Corresponding Author), Inst Pasteur, Paris, France. - Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. - Schmidt-Hieber, Christoph, Inst Pasteur, Paris, France. - Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland.}, - doi = {10.1038/nn.4652}, - issn = {1097-6256}, - eissn = {1546-1726}, - keywords-plus = {HIPPOCAMPAL PYRAMIDAL CELLS; MEDIAL ENTORHINAL CORTEX; THETA PHASE - PRECESSION; LONG-TERM POTENTIATION; PLACE CELLS; DENDRITIC INTEGRATION; - HCN1 CHANNELS; DISTAL DENDRITES; STELLATE CELLS; GRID CELLS}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {christoph.schmidt-hieber@pasteur.fr - mattnolan@ed.ac.uk}, - affiliations = {Le Reseau International des Instituts Pasteur (RIIP); Universite Paris - Cite; Institut Pasteur Paris; University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Schmidt-Hieber, Christoph/0000-0002-5328-9704}, - funding-acknowledgement = {BBSRC {[}BB/M025454/1, BB/L010496/1]; Human Frontiers Science Program - {[}RGP0062/2014]; Wellcome Trust {[}200855/Z/16/Z]; Simons Initiative - for the Developing Brain; ERC {[}StG 678790 NEWRON]; Biotechnology and - Biological Sciences Research Council {[}BB/L010496/1, BB/M025454/1] - Funding Source: researchfish; BBSRC {[}BB/L010496/1, BB/M025454/1] - Funding Source: UKRI; Wellcome Trust {[}200855/Z/16/Z] Funding Source: - Wellcome Trust}, - funding-text = {We thank N. Rochefort and G. Surmeli for comments on the manuscript, A. - Lee for sharing data before publication (ref. 26), and G. Buzsaki and E. - Stark for sharing material for the generation of figures. This work was - funded in part by the BBSRC (grants BB/M025454/1 and BB/L010496/1 to - M.F.N.), the Human Frontiers Science Program (grant RGP0062/2014 to - M.F.N.), the Wellcome Trust (grant 200855/Z/16/Z to M.F.N.), the Simons - Initiative for the Developing Brain (M.F.N.) and the ERC (grant StG - 678790 NEWRON to C.S.-H.).}, - number-of-cited-references = {149}, - times-cited = {23}, - usage-count-last-180-days = {0}, - usage-count-since-2013 = {44}, - journal-iso = {Nat. Neurosci.}, - doc-delivery-number = {FL0QV}, +@article{WOS:000263924500013, + abbr = {NOLAN}, + abstract = {The transformation of synaptic input into patterns of spike output is a + fundamental operation that is determined by the particular complement of + ion channels that a neuron expresses. Although it is well established + that individual ion channel proteins make stochastic transitions between + conducting and non-conducting states, most models of synaptic + integration are deterministic, and relatively little is known about the + functional consequences of interactions between stochastically gating + ion channels. Here, we show that a model of stellate neurons from layer + II of the medial entorhinal cortex implemented with either stochastic or + deterministically gating ion channels can reproduce the resting membrane + properties of stellate neurons, but only the stochastic version of the + model can fully account for perithreshold membrane potential + fluctuations and clustered patterns of spike output that are recorded + from stellate neurons during depolarized states. We demonstrate that the + stochastic model implements an example of a general mechanism for + patterning of neuronal output through activity-dependent changes in the + probability of spike firing. Unlike deterministic mechanisms that + generate spike patterns through slow changes in the state of model + parameters, this general stochastic mechanism does not require retention + of information beyond the duration of a single spike and its associated + afterhyperpolarization. Instead, clustered patterns of spikes emerge in + the stochastic model of stellate neurons as a result of a transient + increase in firing probability driven by activation of HCN channels + during recovery from the spike afterhyperpolarization. Using this model, + we infer conditions in which stochastic ion channel gating may influence}, + address = {1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA}, + affiliation = {Dudman, JT (Corresponding Author), Howard Hughes Med Inst, Janelia Farm Res Campus, Ashburn, VA USA. + Dudman, Joshua T., Howard Hughes Med Inst, Ashburn, VA USA. + Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, RDSVS, Edinburgh, Midlothian, Scotland.}, + affiliations = {Howard Hughes Medical Institute; University of Edinburgh}, + article-number = {e1000290}, + author = {Dudman, Joshua T. and Nolan, Matthew F.}, + author-email = {dudmanj@janelia.hhmi.org}, + da = {2024-02-13}, + doc-delivery-number = {415HI}, + doi = {10.1371/journal.pcbi.1000290}, + eissn = {1553-7358}, + funding-acknowledgement = {National Institutes of Health {[}NS36658]; National Science Foundation + (JTD; Marie Curie Excellence; Biotechnology and Biological Sciences + Research Council Tools and Resources Award (MFN); Howard Hughes Medical + Institute; BBSRC {[}BB/E014526/1] Funding Source: UKRI; MRC {[}G0501216] + Funding Source: UKRI; Biotechnology and Biological Sciences Research + Council {[}BB/E014526/1] Funding Source: researchfish; Medical Research + Council {[}G0501216] Funding Source: researchfish}, + funding-text = {Initial parts of this work were generously supported by Steven A. + Siegelbaum (National Institutes of Health Grant NS36658) and in part by + a Graduate Research Fellowship from the National Science Foundation + (JTD), with continued support from a Marie Curie Excellence grant (MFN) + and a Biotechnology and Biological Sciences Research Council Tools and + Resources Award (MFN). JTD is a Janelia Farm Research Campus Fellow of + the Howard Hughes Medical Institute.}, + issn = {1553-734X}, + journal = {PLOS COMPUTATIONAL BIOLOGY}, + journal-iso = {PLoS Comput. Biol.}, + keywords-plus = {CORTEX LAYER-II; HYPERPOLARIZATION-ACTIVATED CURRENTS; ENTORHINAL + CORTEX; SUBTHRESHOLD OSCILLATIONS; STELLATE CELLS; DIFFERENTIAL + ELECTRORESPONSIVENESS; INTEGRATIVE PROPERTIES; NEURAL INFORMATION; + DISTAL DENDRITES; NOISE}, + language = {English}, + month = {FEB}, + number = {2}, + number-of-cited-references = {66}, + oa = {Green Published, gold, Green Submitted}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Dudman, Joshua/0000-0002-4436-1057}, + publisher = {PUBLIC LIBRARY SCIENCE}, + research-areas = {Biochemistry \& Molecular Biology; Mathematical \& Computational Biology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + }, + times-cited = {31}, + title = {Stochastically Gating Ion Channels Enable Patterned Spike Firing through + Activity-Dependent Modulation of Spike Probability}, + type = {Article}, + unique-id = {WOS:000263924500013}, + usage-count-last-180-days = {0}, + usage-count-since-2013 = {4}, + volume = {5}, + web-of-science-categories = {Biochemical Research Methods; Mathematical \& Computational Biology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000413916800007}, - oa = {Green Accepted}, - da = {2024-02-13} + year = {2009} +} + +@article{WOS:000281389500018, + abbr = {NOLAN}, + abstract = {Neuronal activity is mediated through changes in the probability of + stochastic transitions between open and closed states of ion channels. + While differences in morphology define neuronal cell types and may + underlie neurological disorders, very little is known about influences + of stochastic ion channel gating in neurons with complex morphology. We + introduce and validate new computational tools that enable efficient + generation and simulation of models containing stochastic ion channels + distributed across dendritic and axonal membranes. Comparison of five + morphologically distinct neuronal cell types reveals that when all + simulated neurons contain identical densities of stochastic ion + channels, the amplitude of stochastic membrane potential fluctuations + differs between cell types and depends on sub-cellular location. For + typical neurons, the amplitude of membrane potential fluctuations + depends on channel kinetics as well as open probability. Using a + detailed model of a hippocampal CA1 pyramidal neuron, we show that when + intrinsic ion channels gate stochastically, the probability of + initiation of dendritic or somatic spikes by dendritic synaptic input + varies continuously between zero and one, whereas when ion channels gate + deterministically, the probability is either zero or one. At + physiological firing rates, stochastic gating of dendritic ion channels + almost completely accounts for probabilistic somatic and dendritic + spikes generated by the fully stochastic model. These results suggest + that the consequences of stochastic ion channel gating differ globally + between neuronal cell-types and locally between neuronal compartments. + Whereas dendritic neurons are often assumed to behave deterministically, + our simulations suggest that a direct consequence of stochastic gating + of intrinsic ion channels is that spike output may instead be a + probabilistic function of patterns of synaptic input to dendrites.}, + address = {1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA}, + affiliation = {Cannon, RC (Corresponding Author), Textensor Ltd, Edinburgh, Midlothian, Scotland. + Cannon, Robert C., Textensor Ltd, Edinburgh, Midlothian, Scotland. + O'Donnell, Cian, Univ Edinburgh, Neuroinformat Doctoral Training Ctr, Edinburgh, Midlothian, Scotland. + Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh}, + article-number = {e1000886}, + author = {Cannon, Robert C. and O'Donnell, Cian and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {644OU}, + doi = {10.1371/journal.pcbi.1000886}, + eissn = {1553-7358}, + funding-acknowledgement = {BBSRC {[}BB/E014527/1]; Marie Curie Excellence; Network of European + Neuroscience Institutes; EPSRC; eDIKT initiative; Biotechnology and + Biological Sciences Research Council {[}BB/E014526/1] Funding Source: + researchfish; BBSRC {[}BB/E014526/1] Funding Source: UKRI}, + funding-text = {This work was supported by a BBSRC Tools and Resources Fund award + (BB/E014527/1 to MFN), a Marie Curie Excellence grant (MFN), the Network + of European Neuroscience Institutes (http://www.eni-net.org/) and the + EPSRC (C'OD). This work has made use of the resources provided by the + ECDF (http://www.ecdf.ed.ac.uk/). The ECDF is partially supported by the + eDIKT initiative (http://www.edikt.org.uk). The funders had no role in + study design, data collection and analysis, decision to publish, or + preparation of the manuscript.}, + issn = {1553-734X}, + journal = {PLOS COMPUTATIONAL BIOLOGY}, + journal-iso = {PLoS Comput. Biol.}, + keywords-plus = {ACTION-POTENTIALS; INTEGRATIVE PROPERTIES; CURRENT FLUCTUATIONS; + PYRAMIDAL NEURONS; K+ CHANNELS; PROPAGATION; MEMBRANE; NOISE; + SIMULATION; CONDUCTANCE}, + language = {English}, + month = {AUG}, + number = {8}, + number-of-cited-references = {72}, + oa = {Green Published, gold}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + O'Donnell, Cian/0000-0003-2031-9177}, + publisher = {PUBLIC LIBRARY SCIENCE}, + research-areas = {Biochemistry \& Molecular Biology; Mathematical \& Computational Biology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + }, + times-cited = {57}, + title = {Stochastic Ion Channel Gating in Dendritic Neurons: Morphology + Dependence and Probabilistic Synaptic Activation of Dendritic Spikes}, + type = {Article}, + unique-id = {WOS:000281389500018}, + usage-count-last-180-days = {0}, + usage-count-since-2013 = {9}, + volume = {6}, + web-of-science-categories = {Biochemical Research Methods; Mathematical \& Computational Biology}, + web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, + year = {2010} } @article{WOS:000287833900001, - author = {O'Donnell, Cian and Nolan, Matthew F.}, - title = {Tuning of synaptic responses: an organizing principle for optimization - of neural circuits}, - journal = {TRENDS IN NEUROSCIENCES}, - year = {2011}, - volume = {34}, - number = {2}, - pages = {51-60}, - month = {FEB}, + abbr = {NOLAN}, abstract = {Neuron types are classically defined by anatomical and physiological properties that determine how synaptic inputs are integrated. Here, we provide an overview of the evidence that, among neurons of a single @@ -376,28 +408,17 @@ @article{WOS:000287833900001 complementary to, homeostasis and memory storage. These cellular tuning mechanisms might be crucial for distributed computations underlying sensory, motor and cognitive functions.}, - publisher = {ELSEVIER SCIENCE LONDON}, address = {84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND}, - type = {Review}, - language = {English}, affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. O'Donnell, Cian, Univ Edinburgh, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9AB, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh}, + author = {O'Donnell, Cian and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {727WP}, doi = {10.1016/j.tins.2010.10.003}, - issn = {0166-2236}, eissn = {1878-108X}, - keywords-plus = {AUDITORY BRAIN-STEM; MEDIAL ENTORHINAL CORTEX; LONG-TERM POTENTIATION; - INTRINSIC EXCITABILITY; STELLATE CELLS; SUBTHRESHOLD OSCILLATIONS; - STRUCTURAL PLASTICITY; COINCIDENCE DETECTION; NUCLEUS LAMINARIS; FIRING - FEATURES}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - O'Donnell, Cian/0000-0003-2031-9177}, funding-acknowledgement = {Biotechnology and Biological Sciences Research Council; Medical Research Council; Marie Curie Excellence grant; Engineering and Physical Sciences Research Council; BBSRC {[}BB/H020284/1] Funding Source: UKRI; MRC @@ -410,150 +431,118 @@ @ed.ac.uk Sciences Research Council (M.F.N.), Medical Research Council (M.F.N.), a Marie Curie Excellence grant (M.F.N.) and the Engineering and Physical Sciences Research Council (C O'D).}, + issn = {0166-2236}, + journal = {TRENDS IN NEUROSCIENCES}, + journal-iso = {Trends Neurosci.}, + keywords-plus = {AUDITORY BRAIN-STEM; MEDIAL ENTORHINAL CORTEX; LONG-TERM POTENTIATION; + INTRINSIC EXCITABILITY; STELLATE CELLS; SUBTHRESHOLD OSCILLATIONS; + STRUCTURAL PLASTICITY; COINCIDENCE DETECTION; NUCLEUS LAMINARIS; FIRING + FEATURES}, + language = {English}, + month = {FEB}, + number = {2}, number-of-cited-references = {94}, + oa = {Green Accepted}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + O'Donnell, Cian/0000-0003-2031-9177}, + pages = {51-60}, + publisher = {ELSEVIER SCIENCE LONDON}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + }, times-cited = {21}, + title = {Tuning of synaptic responses: an organizing principle for optimization + of neural circuits}, + type = {Review}, + unique-id = {WOS:000287833900001}, usage-count-last-180-days = {1}, usage-count-since-2013 = {17}, - journal-iso = {Trends Neurosci.}, - doc-delivery-number = {727WP}, + volume = {34}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000287833900001}, - oa = {Green Accepted}, - da = {2024-02-13} + year = {2011} } -@article{WOS:000379804700002, - author = {Nolan, Matthew F.}, - title = {Local field potentials get funny}, - journal = {JOURNAL OF PHYSIOLOGY-LONDON}, - year = {2016}, - volume = {594}, - number = {13}, - pages = {3487-3488}, - month = {JUL 1}, - publisher = {WILEY-BLACKWELL}, - address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, - type = {Editorial Material}, - language = {English}, +@article{WOS:000288736500012, + abbr = {NOLAN}, + abstract = {The axon initial segment (AIS) is critical for the initiation and + propagation of action potentials. Assembly of the AIS requires + interactions between scaffolding molecules and voltage-gated sodium + channels, but the molecular mechanisms that stabilize the AIS are poorly + understood. The neuronal isoform of Neurofascin, Nfasc186, clusters + voltage-gated sodium channels at nodes of Ranvier in myelinated nerves: + here, we investigate its role in AIS assembly and stabilization. + Inactivation of the Nfasc gene in cerebellar Purkinje cells of adult + mice causes rapid loss of Nfasc186 from the AIS but not from nodes of + Ranvier. This causes AIS disintegration, impairment of motor learning + and the abolition of the spontaneous tonic discharge typical of Purkinje + cells. Nevertheless, action potentials with a modified waveform can + still be evoked and basic motor abilities remain intact. We propose that + Nfasc186 optimizes communication between mature neurons by anchoring the + key elements of the adult AIS complex.}, + address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. - Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1113/JP272673}, - issn = {0022-3751}, - eissn = {1469-7793}, - keywords-plus = {CURRENTS}, - research-areas = {Neurosciences \& Neurology; Physiology}, - web-of-science-categories = {Neurosciences; Physiology}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009}, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501}, - funding-acknowledgement = {BBSRC {[}BB/L010496/1] Funding Source: UKRI; Biotechnology and - Biological Sciences Research Council {[}BB/L010496/1] Funding Source: - researchfish}, - number-of-cited-references = {7}, - times-cited = {0}, - usage-count-last-180-days = {0}, - usage-count-since-2013 = {4}, - journal-iso = {J. Physiol.-London}, - doc-delivery-number = {DR3LM}, - web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000379804700002}, - oa = {Green Published, hybrid}, - da = {2024-02-13} -} - -@article{WOS:000389029900005, - author = {Nolan, Matthew F.}, - title = {Neural mechanisms for spatial computation}, - journal = {JOURNAL OF PHYSIOLOGY-LONDON}, - year = {2016}, - volume = {594}, - number = {22}, - pages = {6487-6488}, - month = {NOV 15}, - publisher = {WILEY-BLACKWELL}, - address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, - type = {Editorial Material}, + Rinaldi, Arianna; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. + Zonta, Barbara; Desmazieres, Anne; Tait, Steven; Sherman, Diane L.; Brophy, Peter J., Univ Edinburgh, Ctr Neuroregenerat, Edinburgh EH16 4SB, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh}, + author = {Zonta, Barbara and Desmazieres, Anne and Rinaldi, Arianna and Tait, + Steven and Sherman, Diane L. and Nolan, Matthew F. and Brophy, Peter J.}, + author-email = {mattnolan@ed.ac.uk + peter.brophy@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {739RU}, + doi = {10.1016/j.neuron.2011.02.021}, + eissn = {1097-4199}, + funding-acknowledgement = {Medical Research Council; Wellcome Trust; Marie Curie Excellence Grant; + ARSEP; EU; Medical Research Council {[}G0501216, G0301172] Funding + Source: researchfish; MRC {[}G0501216, G0301172] Funding Source: UKRI}, + funding-text = {We thank Heather Anderson for excellent assistance. We acknowledge + generous gifts of tissue from NrCAM-null mice from Dr Valerie Castellani + (University of Lyon), and these mice were originally generated by Dr + Fritz Rathjen (Max-Delbruck-Centre, Berlin) to whom thanks are due for + tissue used in preliminary experiments. Drs. V. Bennett and M. Rasband + are thanked for generous gifts of antibodies to AnkyrinG and Caspr, + respectively. We gratefully acknowledge the gift of the CreERT2 cassette + from Prof. P. Chambon (IGBMC/GIE-CERBM). This work was supported by the + Medical Research Council, the Wellcome Trust, a Marie Curie Excellence + Grant, ARSEP, and an EU Framework 7 grant to NGIDD.}, + issn = {0896-6273}, + journal = {NEURON}, + journal-iso = {Neuron}, + keywords-plus = {CEREBELLAR PURKINJE NEURONS; CELL-ADHESION MOLECULES; BETA-IV-SPECTRIN; + SODIUM-CHANNEL BETA-1; ANKYRIN-G; PYRAMIDAL NEURONS; NERVOUS-SYSTEM; ION + CHANNELS; NA CHANNELS; L1 FAMILY}, language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. - Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1113/JP273087}, - issn = {0022-3751}, - eissn = {1469-7793}, - keywords-plus = {ENTORHINAL CORTEX; HEAD-DIRECTION; GRID CELLS}, - research-areas = {Neurosciences \& Neurology; Physiology}, - web-of-science-categories = {Neurosciences; Physiology}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009}, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501}, - funding-acknowledgement = {Biotechnology and Biological Sciences Research Council {[}BB/L010496/1] - Funding Source: researchfish; BBSRC {[}BB/L010496/1] Funding Source: - Medline; BBSRC {[}BB/L010496/1] Funding Source: UKRI}, - number-of-cited-references = {23}, - times-cited = {0}, - usage-count-last-180-days = {0}, - usage-count-since-2013 = {2}, - journal-iso = {J. Physiol.-London}, - doc-delivery-number = {ED7GI}, - web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000389029900005}, - oa = {Green Published, hybrid}, - da = {2024-02-13} -} - -@article{WOS:001110181200001, - author = {Nolan, Matthew F.}, - title = {Memory consolidation: Building influence over the entorhinal cortex}, - journal = {CURRENT BIOLOGY}, - year = {2023}, - volume = {33}, - number = {21}, - pages = {R1160-R1162}, - month = {NOV 6}, - abstract = {Memory consolidation involves interactions between the hippocampus and - other cortical areas. A new study identifies neurons in the medial - entorhinal cortex that over learning increase their coordination with - hippocampal replay events, suggesting a route for consolidation of - spatial memories.}, + month = {MAR 10}, + number = {5}, + number-of-cited-references = {64}, + oa = {hybrid, Green Submitted, Green Published}, + orcid-numbers = {RINALDI, ARIANNA/0000-0002-5167-7420 + Rinaldi, Arianna/0000-0002-5167-7420 + Nolan, Matthew F/0000-0003-1062-6501 + Desmazieres, Anne/0000-0001-6542-4566}, + pages = {945-956}, publisher = {CELL PRESS}, - address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, - type = {Editorial Material}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Simons Initiat Developing Brain, Hugh Robson Bldg, Edinburgh EH8 9XD, Scotland. - Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Simons Initiat Developing Brain, Hugh Robson Bldg, Edinburgh EH8 9XD, Scotland.}, - doi = {10.1016/j.cub.2023.09.072}, - earlyaccessdate = {NOV 2023}, - issn = {0960-9822}, - eissn = {1879-0445}, - keywords-plus = {SHARP WAVE-RIPPLE; HIPPOCAMPAL; REPLAY; LAYERS; OSCILLATIONS; NEURONS}, - research-areas = {Biochemistry \& Molecular Biology; Life Sciences \& Biomedicine - Other - Topics; Cell Biology}, - web-of-science-categories = {Biochemistry \& Molecular Biology; Biology; Cell Biology}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh}, - number-of-cited-references = {19}, - times-cited = {0}, - usage-count-last-180-days = {4}, - usage-count-since-2013 = {4}, - journal-iso = {Curr. Biol.}, - doc-delivery-number = {Z2BJ6}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {RINALDI, ARIANNA/AGG-5346-2022 + Rinaldi, Arianna/F-4713-2018 + Nolan, Matthew F/A-1356-2009 + }, + times-cited = {112}, + title = {A Critical Role for Neurofascin in Regulating Action Potential + Initiation through Maintenance of the Axon Initial Segment}, + type = {Article}, + unique-id = {WOS:000288736500012}, + usage-count-last-180-days = {0}, + usage-count-since-2013 = {12}, + volume = {69}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:001110181200001}, - da = {2024-02-13} + year = {2011} } @article{WOS:000292205900012, - author = {Dodson, Paul D. and Pastoll, Hugh and Nolan, Matthew F.}, - title = {Dorsal-ventral organization of theta-like activity intrinsic to - entorhinal stellate neurons is mediated by differences in stochastic - current fluctuations}, - journal = {JOURNAL OF PHYSIOLOGY-LONDON}, - year = {2011}, - volume = {589}, - number = {12}, - pages = {2993-3008}, - month = {JUN 15}, + abbr = {NOLAN}, abstract = {The membrane potential dynamics of stellate neurons in layer II of the medial entorhinal cortex are important for neural encoding of location. Previous studies suggest that these neurons generate intrinsic @@ -578,26 +567,17 @@ @article{WOS:000292205900012 potential activity is due to differences in stochastic current fluctuations resulting from organization of ion channels that also control synaptic integration.}, - publisher = {WILEY}, address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, - type = {Article}, - language = {English}, affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. Dodson, Paul D.; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. Pastoll, Hugh, Univ Edinburgh, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh}, + author = {Dodson, Paul D. and Pastoll, Hugh and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {785CV}, doi = {10.1113/jphysiol.2011.205021}, - issn = {0022-3751}, eissn = {1469-7793}, - keywords-plus = {CORTEX LAYER-II; SUBTHRESHOLD OSCILLATIONS; PHASE NOISE; GRID CELLS; - H-CURRENT; FREQUENCY; DYNAMICS; INTERFERENCE; RHYTHMICITY; COMPUTATION}, - research-areas = {Neurosciences \& Neurology; Physiology}, - web-of-science-categories = {Neurosciences; Physiology}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Dodson, Paul/0000-0003-0858-6088}, funding-acknowledgement = {Biotechnology and Biological Sciences Research Council; Marie Curie Excellence; Commonwealth Scholarships Commission; Biotechnology and Biological Sciences Research Council {[}BB/H020284/1, BB/E014526/1] @@ -606,333 +586,365 @@ @ed.ac.uk funding-text = {This work was supported by the Biotechnology and Biological Sciences Research Council (M.F.N.), a Marie Curie Excellence grant (M.F.N.) and the Commonwealth Scholarships Commission (H. P.).}, + issn = {0022-3751}, + journal = {JOURNAL OF PHYSIOLOGY-LONDON}, + journal-iso = {J. Physiol.-London}, + keywords-plus = {CORTEX LAYER-II; SUBTHRESHOLD OSCILLATIONS; PHASE NOISE; GRID CELLS; + H-CURRENT; FREQUENCY; DYNAMICS; INTERFERENCE; RHYTHMICITY; COMPUTATION}, + language = {English}, + month = {JUN 15}, + number = {12}, number-of-cited-references = {42}, + oa = {Green Published}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Dodson, Paul/0000-0003-0858-6088}, + pages = {2993-3008}, + publisher = {WILEY}, + research-areas = {Neurosciences \& Neurology; Physiology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + }, times-cited = {24}, + title = {Dorsal-ventral organization of theta-like activity intrinsic to + entorhinal stellate neurons is mediated by differences in stochastic + current fluctuations}, + type = {Article}, + unique-id = {WOS:000292205900012}, usage-count-last-180-days = {0}, usage-count-since-2013 = {4}, - journal-iso = {J. Physiol.-London}, - doc-delivery-number = {785CV}, + volume = {589}, + web-of-science-categories = {Neurosciences; Physiology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000292205900012}, - oa = {Green Published}, - da = {2024-02-13} + year = {2011} } -@article{WOS:000389029900011, - author = {Shipston-Sharman, Oliver and Solanka, Lukas and Nolan, Matthew F.}, - title = {Continuous attractor network models of grid cell firing based on - excitatory-inhibitory interactions}, - journal = {JOURNAL OF PHYSIOLOGY-LONDON}, - year = {2016}, - volume = {594}, - number = {22}, - pages = {6547-6557}, - month = {NOV 15}, - abstract = {Neurons in the medial entorhinal cortex encode location through spatial - firing fields that have a grid-like organisation. The challenge of - identifying mechanisms for grid firing has been addressed through - experimental and theoretical investigations of medial entorhinal - circuits. Here, we discuss evidence for continuous attractor network - models that account for grid firing by synaptic interactions between - excitatory and inhibitory cells. These models assume that grid-like - firing patterns are the result of computation of location from velocity - inputs, with additional spatial input required to oppose drift in the - attractor state. We focus on properties of continuous attractor networks - that are revealed by explicitly considering excitatory and inhibitory - neurons, their connectivity and their membrane potential dynamics. - Models at this level of detail can account for theta-nested gamma - oscillations as well as grid firing, predict spatial firing of - interneurons as well as excitatory cells, show how gamma oscillations - can bemodulated independently from spatial computations, reveal critical - roles for neuronal noise, and demonstrate that only a subset of - excitatory cells in a network need have grid-like firing fields. - Evaluating experimental data against predictions from detailed network - models will be important for establishing the mechanisms mediating grid - firing.}, - publisher = {WILEY}, - address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, - type = {Review}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. - Shipston-Sharman, Oliver; Solanka, Lukas; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1113/JP270630}, - issn = {0022-3751}, - eissn = {1469-7793}, - keywords-plus = {ENTORHINAL CORTEX; PATH-INTEGRATION; GAMMA OSCILLATIONS; PHASE - PRECESSION; LAYER-II; DYNAMICS; INTERNEURONS; MECHANISMS; - REPRESENTATION; INTERFERENCE}, - research-areas = {Neurosciences \& Neurology; Physiology}, - web-of-science-categories = {Neurosciences; Physiology}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - Shipston-Sharman, Oliver/Q-5431-2018}, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Shipston-Sharman, Oliver/0000-0002-6529-1537}, - funding-acknowledgement = {BBSRC {[}Bb/L010496/1, Bb/1022147/1]; Biotechnology and Biological - Sciences Research Council {[}BB/L010496/1, BB/I022147/1] Funding Source: - researchfish; BBSRC {[}BB/L010496/1, BB/I022147/1] Funding Source: UKRI}, - funding-text = {This work was supported by grants to M.F.N. from the BBSRC (Bb/L010496/1 - and Bb/1022147/1).}, - number-of-cited-references = {57}, - times-cited = {38}, - usage-count-last-180-days = {1}, - usage-count-since-2013 = {24}, - journal-iso = {J. Physiol.-London}, - doc-delivery-number = {ED7GI}, +@article{WOS:000296799700014, + abbr = {NOLAN}, + abstract = {Long-term synaptic plasticity requires postsynaptic influx of Ca(2+) and + is accompanied by changes in dendritic spine size. Unless Ca(2+) influx + mechanisms and spine volume scale proportionally, changes in spine size + will modify spine Ca(2+) concentrations during subsequent synaptic + activation. We show that the relationship between Ca(2+) influx and + spine volume is a fundamental determinant of synaptic stability. If + Ca(2+) influx is undercompensated for increases in spine size, then + strong synapses are stabilized and synaptic strength distributions have + a single peak. In contrast, overcompensation of Ca(2+) influx leads to + binary, persistent synaptic strengths with double-peaked distributions. + Biophysical simulations predict that CA1 pyramidal neuron spines are + undercompensating. This unifies experimental findings that weak synapses + are more plastic than strong synapses, that synaptic strengths are + unimodally distributed, and that potentiation saturates for a given + stimulus strength. We conclude that structural plasticity provides a + simple, local, and general mechanism that allows dendritic spines to + foster both rapid memory formation and persistent memory storage.}, + address = {11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA}, + affiliation = {O'Donnell, C (Corresponding Author), Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Room 2-51,10 Crichton St, Edinburgh EH8 9AB, Midlothian, Scotland. + O'Donnell, Cian, Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9AB, Midlothian, Scotland. + O'Donnell, Cian; van Rossum, Mark C. W., Univ Edinburgh, Sch Informat, Inst Adapt \& Neural Computat, Edinburgh EH8 9AB, Midlothian, Scotland. + Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh; University of + Edinburgh}, + author = {O'Donnell, Cian and Nolan, Matthew F. and van Rossum, Mark C. W.}, + author-email = {cian.odonnell@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {845CE}, + doi = {10.1523/JNEUROSCI.2520-11.2011}, + funding-acknowledgement = {Medical Research Council; Engineering and Physical Sciences Research + Council; Biotechnology and Biological Sciences Research Council; Human + Frontier Science Program; Marie Curie Excellence grant; BBSRC + {[}BB/H020284/1] Funding Source: UKRI; Biotechnology and Biological + Sciences Research Council {[}BB/H020284/1] Funding Source: researchfish}, + funding-text = {This work was supported by the Medical Research Council (C.O. and + M.F.N.), the Engineering and Physical Sciences Research Council (C.O. + and M. C. W. v. R.), the Biotechnology and Biological Sciences Research + Council (M.F.N.), the Human Frontier Science Program (M. C. W. v. R.), + and a Marie Curie Excellence grant (M.F.N.). We thank Matthias Hennig, + Thomas Oertner, Clare Puddifoot, and Arianna Rinaldi for comments on the + manuscript.}, + issn = {0270-6474}, + journal = {JOURNAL OF NEUROSCIENCE}, + journal-iso = {J. Neurosci.}, + keywords-plus = {TIMING-DEPENDENT PLASTICITY; NEOCORTEX IN-VIVO; ASYMMETRIC HEBBIAN + PLASTICITY; RAT VISUAL-CORTEX; CALCIUM-CHANNELS; HIPPOCAMPAL SYNAPSES; + ULTRASTRUCTURAL ANALYSIS; STRUCTURAL PLASTICITY; NMDA RECEPTORS; ADULT + CORTEX}, + language = {English}, + month = {NOV 9}, + number = {45}, + number-of-cited-references = {101}, + oa = {hybrid, Green Published}, + orcid-numbers = {van Rossum, Mark/0000-0001-6525-6814 + Nolan, Matthew F/0000-0003-1062-6501 + O'Donnell, Cian/0000-0003-2031-9177}, + pages = {16142-16156}, + publisher = {SOC NEUROSCIENCE}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {van Rossum, Mark/AAF-6620-2019 + van Rossum, Mark/N-8426-2014 + Nolan, Matthew F/A-1356-2009 + }, + times-cited = {50}, + title = {Dendritic Spine Dynamics Regulate the Long-Term Stability of Synaptic + Plasticity}, + type = {Article}, + unique-id = {WOS:000296799700014}, + usage-count-last-180-days = {0}, + usage-count-since-2013 = {16}, + volume = {31}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000389029900011}, - oa = {Green Published, Green Accepted, hybrid}, - da = {2024-02-13} + year = {2011} } -@article{WOS:000568891400011, - author = {Gerlei, Klara and Passlack, Jessica and Hawes, Ian and Vandrey, Brianna - and Stevens, Holly and Papastathopoulos, Ioannis and Nolan, Matthew F.}, - title = {Grid cells are modulated by local head direction}, - journal = {NATURE COMMUNICATIONS}, - year = {2020}, - volume = {11}, - number = {1}, - month = {AUG 24}, - abstract = {Grid and head direction codes represent cognitive spaces for navigation - and memory. Pure grid cells generate grid codes that have been assumed - to be independent of head direction, whereas conjunctive cells generate - grid representations that are tuned to a single head direction. Here, we - demonstrate that pure grid cells also encode head direction, but through - distinct mechanisms. We show that individual firing fields of pure grid - cells are tuned to multiple head directions, with the preferred sets of - directions differing between fields. This local directional modulation - is not predicted by previous continuous attractor or oscillatory - interference models of grid firing but is accounted for by models in - which pure grid cells integrate inputs from co-aligned conjunctive cells - with firing rates that differ between their fields. We suggest that - local directional signals from grid cells may contribute to downstream - computations by decorrelating different points of view from the same - location. Neurons with grid firing fields are thought to play important - roles in spatial cognition. Here, the authors show that in contrast to - assumptions underlying current models and analyses, grid fields are - modulated by local head direction; this suggests different mechanisms - and new roles for grid firing.}, - publisher = {NATURE PUBLISHING GROUP}, - address = {MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND}, - type = {Article}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. - Nolan, MF (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh EH8 9XD, Midlothian, Scotland. - Gerlei, Klara; Passlack, Jessica; Hawes, Ian; Vandrey, Brianna; Stevens, Holly; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. - Papastathopoulos, Ioannis, Univ Edinburgh, Sch Math, Maxwell Inst, Edinburgh EH9 3FD, Midlothian, Scotland. - Papastathopoulos, Ioannis, Univ Edinburgh, Ctr Stat, Edinburgh EH9 3FD, Midlothian, Scotland. - Papastathopoulos, Ioannis, Alan Turing Inst, 96 Euston Rd, London NW1 2DB, England. - Nolan, Matthew F., Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1038/s41467-020-17500-1}, - article-number = {4228}, - issn = {2041-1723}, - keywords-plus = {MEDIAL ENTORHINAL CORTEX; PATH-INTEGRATION; PATTERN SEPARATION; STELLATE - CELLS; MODEL; MAP; OSCILLATIONS; MECHANISMS; NAVIGATION; MEMORY}, - research-areas = {Science \& Technology - Other Topics}, - web-of-science-categories = {Multidisciplinary Sciences}, +@article{WOS:000303126700001, + abbr = {NOLAN}, + abstract = {The medial entorhinal contex (MEC) is an increasingly important focus + for investigation of mechanisms for spatial representation. Grid cells + found in layer II of the MEC are likely to be stellate cells, which form + a major projection to the dentate gyrus. Entorhinal stellate cells are + distinguished by distinct intrinsic electrophysiological properties, but + how these properties contribute to representation of space is not yet + clear. Here, we review the ionic conductances, synaptic, and excitable + properties of stellate cells, and examine thier implication for models + of grid firing fields. We discuss why existing data are inconsistent + with models of grid fields that require stellate cells to generate + periodic oscillation. An alternate possibility is that the intrinsic + electrophysiological properties of stellate cells are tuned specifically + to control integration of synaptic input. We highlight recent evidence + that the dorsal-ventra; organization of synaptic integraiton by stellate + cells, through differences in currents mediated by HCN and leak + potassium channels, influences the corresponding organization of grid + fields. Because accurate cellular data will be important for + distinguishing mechanisms for generation of grid fields, we introduce + new date comparing properties measured with whole-cell and perforated + patch-clamp recordings. We find that clustered patterns of action + potential firing and the action potential after-hyperpolarization (AHP) + are particularly sensitive to recording condition. Neverthless, with + both methods, these properties, resting membrane properties and + resonance follow a dorsal-ventral organization. Further investigation of + the molecular basis for synaptic integration by stellate cells will be + important for understanding mechanisms for generation of grid fields.}, + address = {AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. + Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. + Pastoll, Hugh; Ramsden, Helen L., Univ Edinburgh, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh}, + article-number = {1}, + author = {Pastoll, Hugh and Ramsden, Helen L. and Nolan, Matthew F.}, author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh; Heriot Watt - University; University of Edinburgh; University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Gerlei, Klara/0000-0002-7803-6666 - , Ian/0000-0002-3574-7812 - Papastathopoulos, Ioannis/0000-0002-7498-2540 - Passlack, Jessica/0000-0002-1043-3980}, - funding-acknowledgement = {Wellcome Trust {[}200855/Z/16/Z]; BBSRC {[}BB/L010496/1]; Centre for - Statistics at the University of Edinburgh; College of Medicine and - Veterinary Medicine PhD Studentship - Thomas Work Fellowship; Wellcome - Trust Translational Neuroscience PhD programme {[}108890/Z/15/Z]; BBSRC - {[}BB/L010496/1] Funding Source: UKRI; Wellcome Trust {[}200855/Z/16/Z] - Funding Source: Wellcome Trust}, - funding-text = {We thank Gulen Surmeli and Derek Garden for comments on the manuscript; - Emma Wood, Michael Allerhand and members of the Nolan laboratory for - helpful discussions and Elizabeth Allison for assistance with set up of - open field recordings and initial analysis. We thank scidraw.io for the - mouse schematic. This work was supported by grants to M.F.N. from the - Wellcome Trust (200855/Z/16/Z) and the BBSRC (BB/L010496/1); to I.P. and - M.F.N. from the Centre for Statistics at the University of Edinburgh; by - a College of Medicine and Veterinary Medicine PhD Studentship, funded by - the Thomas Work Fellowship, to K.G. and by the Wellcome Trust - (108890/Z/15/Z) Translational Neuroscience PhD programme to I.H. This - work made use of resources provided by the Edinburgh Compute and Data - Facility.}, - number-of-cited-references = {56}, - times-cited = {17}, + da = {2024-02-13}, + doc-delivery-number = {930GW}, + doi = {10.3389/fncir.2012.00017}, + funding-acknowledgement = {Biotechnology and Biological Sciences Research Council; Engineering and + Physical Sciences Research Council; Commonwealth Scholarships + Commission; BBSRC {[}BB/H020284/1] Funding Source: UKRI}, + funding-text = {This work was supported by the Biotechnology and Biological Sciences + Research Council (Matthew F. Nolan), the Engineering and Physical + Sciences Research Council (Hugh Pastoll and Helen Ramsden) and the + Commonwealth Scholarships Commission (Hugh Pastoll).}, + issn = {1662-5110}, + journal = {FRONTIERS IN NEURAL CIRCUITS}, + journal-iso = {Front. Neural Circuits}, + keywords = {ion channel; grid cell; HCN; synaptic integration; oscillation; theta; + resonance}, + keywords-plus = {LAYER-II STELLATE; INHIBITS NEURONAL EXCITABILITY; VOLTAGE-DEPENDENT + INACTIVATION; ACTIVATED CATION CURRENTS; SUSTAINED SODIUM CURRENT; + PERSISTENT NA+ CURRENT; SUBTHRESHOLD OSCILLATIONS; PYRAMIDAL NEURONS; + THETA-RHYTHM; IONIC MECHANISMS}, + language = {English}, + month = {APR 24}, + number-of-cited-references = {135}, + oa = {Green Published, gold}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501}, + publisher = {FRONTIERS MEDIA SA}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009}, + times-cited = {45}, + title = {Intrinsic electrophysiological properties of entorhinal cortex stellate + cells and their contribution to grid cell firing fields}, + type = {Article}, + unique-id = {WOS:000303126700001}, usage-count-last-180-days = {1}, - usage-count-since-2013 = {15}, - journal-iso = {Nat. Commun.}, - doc-delivery-number = {NN6JC}, + usage-count-since-2013 = {12}, + volume = {6}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000568891400011}, - oa = {gold, Green Published}, - da = {2024-02-13} + year = {2012} } -@article{WOS:000711952200005, - author = {Gerlei, Klara Z. and Brown, Christina M. and Surmeli, Gulsen and Nolan, +@article{WOS:000313404600014, + abbr = {NOLAN}, + abstract = {Cortical circuits are thought to multiplex firing rate codes with + temporal codes that rely on oscillatory network activity, but the + circuit mechanisms that combine these coding schemes are unclear. We + establish with optogenetic activation of layer II of the medial + entorhinal cortex that theta frequency drive to this circuit is + sufficient to generate nested gamma frequency oscillations in synaptic + activity. These nested gamma oscillations closely resemble activity + during spatial exploration, are generated by local feedback inhibition + without recurrent excitation, and have clock-like features suitable as + reference signals for multiplexing temporal codes within rate-coded grid + firing fields. In network models deduced from our data, feedback + inhibition supports coexistence of theta-nested gamma oscillations with + attractor states that generate grid firing fields. These results + indicate that grid cells communicate primarily via inhibitory + interneurons. This circuit mechanism enables multiplexing of + oscillation-based temporal codes with rate-coded attractor states.}, + address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. + Pastoll, Hugh; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. + Pastoll, Hugh; Solanka, Lukas; van Rossum, Mark C. W., Univ Edinburgh, Sch Informat, Inst Adapt \& Neural Computat, Edinburgh EH8 9AB, Midlothian, Scotland. + Pastoll, Hugh; Solanka, Lukas, Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9AB, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh; University of + Edinburgh}, + author = {Pastoll, Hugh and Solanka, Lukas and van Rossum, Mark C. W. and Nolan, Matthew F.}, - title = {Deep entorhinal cortex: from circuit organization to spatial cognition - and memory}, - journal = {TRENDS IN NEUROSCIENCES}, - year = {2021}, - volume = {44}, - number = {11}, - pages = {876-887}, - month = {NOV}, - abstract = {The deep layers of the entorhinal cortex are important for spatial - cognition, as well as memory storage, consolidation and retrieval. A - long-standing hypothesis is that deep-layer neurons relay spatial and - memory-related signals between the hippocampus and telencephalon. We - review the implications of recent circuit-level analyses that suggest - more complex roles. The organization of deep entorhinal layers is - consistent with multi-stage processing by specialized cell populations; - in this framework, hippocampal, neocortical, and subcortical inputs are - integrated to generate representations for use by targets in the - telencephalon and for feedback to the superficial entorhinal cortex and - hippocampus. Addressing individual sublayers of the deep entorhinal - cortex in future experiments and models will be important for - establishing systems-level mechanisms for spatial cognition and episodic - memory.}, - publisher = {CELL PRESS}, - address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, - type = {Review}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {068ZL}, + doi = {10.1016/j.neuron.2012.11.032}, + eissn = {1097-4199}, + funding-acknowledgement = {Biotechnology and Biological Sciences Research Council; Engineering and + Physical Sciences Research Council; Commonwealth Scholarships + Commission; Biotechnology and Biological Sciences Research Council + {[}BB/H020284/1] Funding Source: researchfish; BBSRC {[}BB/H020284/1] + Funding Source: UKRI}, + funding-text = {This work was supported by the Biotechnology and Biological Sciences + Research Council (M.F.N.), the Engineering and Physical Sciences + Research Council (H.P. and L.S.), and the Commonwealth Scholarships + Commission (H.P.). We thank Ian Duguid for comments on the manuscript + and Patrick Kaifosh for suggestions about network configurations. This + work made use of resources provided by the Edinburgh Compute and Data + Facility. H.P. contributed to design of the study and performed and + analyzed experiments. L.S. contributed to design of the study and + performed and analyzed simulations. M.C.W.v.R. contributed to design of + the study and analysis of simulations. M.F.N. designed and supervised + the study, contributed to data analysis, and wrote the manuscript.}, + issn = {0896-6273}, + journal = {NEURON}, + journal-iso = {Neuron}, + keywords-plus = {MEDIAL ENTORHINAL CORTEX; IN-VITRO; SPATIAL PERIODICITY; + PATH-INTEGRATION; RAT; RHYTHM; CELLS; HIPPOCAMPUS; POSITION; MODEL}, language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Midlothian, Scotland. - Nolan, MF (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Midlothian, Scotland. - Gerlei, Klara Z.; Brown, Christina M.; Surmeli, Gulsen; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Midlothian, Scotland. - Surmeli, Gulsen; Nolan, Matthew F., Univ Edinburgh, Simons Initiat Developing Brain, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1016/j.tins.2021.08.003}, - earlyaccessdate = {OCT 2021}, - issn = {0166-2236}, - eissn = {1878-108X}, - keywords-plus = {COMPLEMENTARY LEARNING-SYSTEMS; LAYER-V NEURONS; PERSISTENT ACTIVITY; - SUPERFICIAL LAYERS; PARAHIPPOCAMPAL REGION; HIPPOCAMPAL-FORMATION; - RIPPLE OSCILLATIONS; CORTICAL-NEURONS; RAT; PROJECTIONS}, + month = {JAN 9}, + number = {1}, + number-of-cited-references = {48}, + oa = {Green Accepted, Bronze, Green Submitted}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + van Rossum, Mark/0000-0001-6525-6814}, + pages = {141-154}, + publisher = {CELL PRESS}, research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh}, researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - SURMELI, GULSEN/0000-0002-3227-0641}, - funding-acknowledgement = {Simons Initiative for the Developing Brain; Wellcome Trust - {[}200855/Z/16/Z, 211236/Z/18/Z]; EastBio PhD programme; Wellcome Trust - {[}211236/Z/18/Z, 200855/Z/16/Z] Funding Source: Wellcome Trust}, - funding-text = {We thank members of the laboratories of M.F.N. and G.S. for helpful - discussions. This work was supported by the Simons Initiative for the - Developing Brain, by awards from the Wellcome Trust (200855/Z/16/Z to - M.F.N. and 211236/Z/18/Z to G.S.) , and by the EastBio PhD programme (to - C.B.) .}, - number-of-cited-references = {92}, - times-cited = {18}, - usage-count-last-180-days = {5}, - usage-count-since-2013 = {18}, - journal-iso = {Trends Neurosci.}, - doc-delivery-number = {WN7MS}, - web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)}, - unique-id = {WOS:000711952200005}, - da = {2024-02-13} + van Rossum, Mark/N-8426-2014 + van Rossum, Mark/AAF-6620-2019}, + times-cited = {199}, + title = {Feedback Inhibition Enables Theta-Nested Gamma Oscillations and Grid + Firing Fields}, + type = {Article}, + unique-id = {WOS:000313404600014}, + usage-count-last-180-days = {1}, + usage-count-since-2013 = {53}, + volume = {77}, + web-of-science-categories = {Neurosciences}, + web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, + year = {2013} } -@article{WOS:000263924500013, - author = {Dudman, Joshua T. and Nolan, Matthew F.}, - title = {Stochastically Gating Ion Channels Enable Patterned Spike Firing through - Activity-Dependent Modulation of Spike Probability}, - journal = {PLOS COMPUTATIONAL BIOLOGY}, - year = {2009}, - volume = {5}, - number = {2}, - month = {FEB}, - abstract = {The transformation of synaptic input into patterns of spike output is a - fundamental operation that is determined by the particular complement of - ion channels that a neuron expresses. Although it is well established - that individual ion channel proteins make stochastic transitions between - conducting and non-conducting states, most models of synaptic - integration are deterministic, and relatively little is known about the - functional consequences of interactions between stochastically gating - ion channels. Here, we show that a model of stellate neurons from layer - II of the medial entorhinal cortex implemented with either stochastic or - deterministically gating ion channels can reproduce the resting membrane - properties of stellate neurons, but only the stochastic version of the - model can fully account for perithreshold membrane potential - fluctuations and clustered patterns of spike output that are recorded - from stellate neurons during depolarized states. We demonstrate that the - stochastic model implements an example of a general mechanism for - patterning of neuronal output through activity-dependent changes in the - probability of spike firing. Unlike deterministic mechanisms that - generate spike patterns through slow changes in the state of model - parameters, this general stochastic mechanism does not require retention - of information beyond the duration of a single spike and its associated - afterhyperpolarization. Instead, clustered patterns of spikes emerge in - the stochastic model of stellate neurons as a result of a transient - increase in firing probability driven by activation of HCN channels - during recovery from the spike afterhyperpolarization. Using this model, - we infer conditions in which stochastic ion channel gating may influence}, - publisher = {PUBLIC LIBRARY SCIENCE}, - address = {1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA}, - type = {Article}, +@article{WOS:000323427000002, + abbr = {NOLAN}, + abstract = {In many cortical neurons, HCN1 channels are the major contributors to + I-h, the hyperpolarization-activated current, which regulates the + intrinsic properties of neurons and shapes their integration of synaptic + inputs, paces rhythmic activity, and regulates synaptic plasticity. + Here, we examine the physiological role of I-h in deep layer pyramidal + neurons in mouse prefrontal cortex (PFC), focusing on persistent + activity, a form of sustained firing thought to be important for the + behavioral function of the PFC during working memory tasks. We find that + HCN1 contributes to the intrinsic persistent firing that is induced by a + brief depolarizing current stimulus in the presence of muscarinic + agonists. Deletion of HCN1 or acute pharmacological blockade of I-h + decreases the fraction of neurons capable of generating persistent + firing. The reduction in persistent firing is caused by the membrane + hyperpolarization that results from the deletion of HCN1 or I-h + blockade, rather than a specific role of the hyperpolarization-activated + current in generating persistent activity. In vivo recordings show that + deletion of HCN1 has no effect on up states, periods of enhanced + synaptic network activity. Parallel behavioral studies demonstrate that + HCN1 contributes to the PFC-dependent resolution of proactive + interference during working memory. These results thus provide genetic + evidence demonstrating the importance of HCN1 to intrinsic persistent + firing and the behavioral output of the PFC. The causal role of + intrinsic persistent firing in PFC-mediated behavior remains an open + question.}, + address = {11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA}, + affiliation = {Kandel, ER (Corresponding Author), Columbia Univ, Dept Neurosci, New York, NY 10032 USA. + Thuault, Sebastien J.; Constantinople, Christine M.; Nicholls, Russell; Chen, Irene; Zhu, Judy; Panteleyev, Andrey; Vronskaya, Svetlana; Bruno, Randy; Siegelbaum, Steven A.; Kandel, Eric R., Columbia Univ, Dept Neurosci, New York, NY 10032 USA. + Malleret, Gael, Fac Med Laennec, CNRS, UMR 5167, F-69372 Lyon, France. + Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. + Bruno, Randy; Siegelbaum, Steven A.; Kandel, Eric R., Columbia Univ, Kavli Inst Brain Sci, New York, NY 10032 USA. + Kandel, Eric R., Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA.}, + affiliations = {Columbia University; Centre National de la Recherche Scientifique + (CNRS); Universite Claude Bernard Lyon 1; University of Edinburgh; + Columbia University; Howard Hughes Medical Institute; Columbia + University}, + author = {Thuault, Sebastien J. and Malleret, Gael and Constantinople, Christine + M. and Nicholls, Russell and Chen, Irene and Zhu, Judy and Panteleyev, + Andrey and Vronskaya, Svetlana and Nolan, Matthew F. and Bruno, Randy + and Siegelbaum, Steven A. and Kandel, Eric R.}, + author-email = {sas8@columbia.edu + erk5@columbia.edu}, + da = {2024-02-13}, + doc-delivery-number = {205FC}, + doi = {10.1523/JNEUROSCI.2427-12.2013}, + funding-acknowledgement = {Howard Hughes Medical Institute from National Institutes of Health + {[}R01 MH045923, MH80745]; National Alliance for Research on + Schizophrenia and Depression Young Investigator Award}, + funding-text = {This work was supported by the Howard Hughes Medical Institute, grants + R01 MH045923 and MH80745 from National Institutes of Health (E.R.K. and + S.A.S.), and a National Alliance for Research on Schizophrenia and + Depression Young Investigator Award (S.J.T.). We are grateful to Bina + Santoro, Eleanor Simpson, Christoph Kellendonk, Pierre Trifilieff, Ilias + Pavlopoulos, Alexei Morozov, Pablo Jercog, Joseph Rayman, Harshad + Vishwasrao, Vivien Chevaleyre, Rebecca Piskorowski, and Alexander + Arguello for technical advice, reagents, and discussions about this + manuscript. We also thank Deqi Yin and Brittany Dubose for expert + technical assistance.}, + issn = {0270-6474}, + journal = {JOURNAL OF NEUROSCIENCE}, + journal-iso = {J. Neurosci.}, + keywords-plus = {NEOCORTICAL PYRAMIDAL NEURONS; GENERAL FLUID INTELLIGENCE; + RAT-ASSOCIATION CORTEX; SHORT-TERM-MEMORY; WORKING-MEMORY; IN-VIVO; + ENTORHINAL CORTEX; UNIT-ACTIVITY; NUCLEUS BASALIS; INTEGRATIVE + PROPERTIES}, language = {English}, - affiliation = {Dudman, JT (Corresponding Author), Howard Hughes Med Inst, Janelia Farm Res Campus, Ashburn, VA USA. - Dudman, Joshua T., Howard Hughes Med Inst, Ashburn, VA USA. - Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, RDSVS, Edinburgh, Midlothian, Scotland.}, - doi = {10.1371/journal.pcbi.1000290}, - article-number = {e1000290}, - issn = {1553-734X}, - eissn = {1553-7358}, - keywords-plus = {CORTEX LAYER-II; HYPERPOLARIZATION-ACTIVATED CURRENTS; ENTORHINAL - CORTEX; SUBTHRESHOLD OSCILLATIONS; STELLATE CELLS; DIFFERENTIAL - ELECTRORESPONSIVENESS; INTEGRATIVE PROPERTIES; NEURAL INFORMATION; - DISTAL DENDRITES; NOISE}, - research-areas = {Biochemistry \& Molecular Biology; Mathematical \& Computational Biology}, - web-of-science-categories = {Biochemical Research Methods; Mathematical \& Computational Biology}, - author-email = {dudmanj@janelia.hhmi.org}, - affiliations = {Howard Hughes Medical Institute; University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + month = {AUG 21}, + number = {34}, + number-of-cited-references = {93}, + oa = {Green Published, hybrid}, + orcid-numbers = {Bruno, Randy M./0000-0002-5122-4632 + Nolan, Matthew F/0000-0003-1062-6501 }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Dudman, Joshua/0000-0002-4436-1057}, - funding-acknowledgement = {National Institutes of Health {[}NS36658]; National Science Foundation - (JTD; Marie Curie Excellence; Biotechnology and Biological Sciences - Research Council Tools and Resources Award (MFN); Howard Hughes Medical - Institute; BBSRC {[}BB/E014526/1] Funding Source: UKRI; MRC {[}G0501216] - Funding Source: UKRI; Biotechnology and Biological Sciences Research - Council {[}BB/E014526/1] Funding Source: researchfish; Medical Research - Council {[}G0501216] Funding Source: researchfish}, - funding-text = {Initial parts of this work were generously supported by Steven A. - Siegelbaum (National Institutes of Health Grant NS36658) and in part by - a Graduate Research Fellowship from the National Science Foundation - (JTD), with continued support from a Marie Curie Excellence grant (MFN) - and a Biotechnology and Biological Sciences Research Council Tools and - Resources Award (MFN). JTD is a Janelia Farm Research Campus Fellow of - the Howard Hughes Medical Institute.}, - number-of-cited-references = {66}, - times-cited = {31}, + pages = {13583-13599}, + publisher = {SOC NEUROSCIENCE}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {Bruno, Randy M./ABC-2117-2021 + Nolan, Matthew F/A-1356-2009 + Panteleyev, Andrey/AAJ-1353-2020}, + times-cited = {59}, + title = {Prefrontal Cortex HCN1 Channels Enable Intrinsic Persistent Neural + Firing and Executive Memory Function}, + type = {Article}, + unique-id = {WOS:000323427000002}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {4}, - journal-iso = {PLoS Comput. Biol.}, - doc-delivery-number = {415HI}, + usage-count-since-2013 = {16}, + volume = {33}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000263924500013}, - oa = {Green Published, gold, Green Submitted}, - da = {2024-02-13} + year = {2013} } @article{WOS:000326899800023, - author = {Rinaldi, Arianna and Defterali, Cagla and Mialot, Antoine and Garden, - Derek L. F. and Beraneck, Mathieu and Nolan, Matthew F.}, - title = {HCN1 channels in cerebellar Purkinje cells promote late stages of - learning and constrain synaptic inhibition}, - journal = {JOURNAL OF PHYSIOLOGY-LONDON}, - year = {2013}, - volume = {591}, - number = {22}, - pages = {5691-5709}, - month = {NOV 15}, + abbr = {NOLAN}, abstract = {Neural computations rely on ion channels that modify neuronal responses to synaptic inputs. While single cell recordings suggest diverse and neurone type-specific computational functions for HCN1 channels, their @@ -948,1532 +960,1083 @@ @article{WOS:000326899800023 not affect responses to excitatory inputs. Our results indicate that manipulation of subthreshold computation in a single neurone type causes specific modifications to behaviour.}, - publisher = {WILEY}, address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, - type = {Article}, - language = {English}, affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. Rinaldi, Arianna; Defterali, Cagla; Garden, Derek L. F.; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. Mialot, Antoine; Beraneck, Mathieu, Univ Paris 05, Sorbonne Paris Cite, Ctr Etude Sensori Motricite, CNRS UMR 8194, Paris, France.}, + affiliations = {University of Edinburgh; Centre National de la Recherche Scientifique + (CNRS); Universite Paris Cite}, + author = {Rinaldi, Arianna and Defterali, Cagla and Mialot, Antoine and Garden, + Derek L. F. and Beraneck, Mathieu and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {251AO}, doi = {10.1113/jphysiol.2013.259499}, - issn = {0022-3751}, eissn = {1469-7793}, + funding-acknowledgement = {Medical Research Council; Marie Curie; NARSAD; Wellcome Trust; Centre + National d'Etudes Spatiales; Medical Research Council {[}G0501216] + Funding Source: researchfish; MRC {[}G0501216] Funding Source: UKRI}, + funding-text = {This study was supported by funding from the Medical Research Council + (to M.F.N.), Marie Curie (to M.F.N.), NARSAD (to M.F.N.) the Wellcome + Trust (to M.F.N.) and Centre National d'Etudes Spatiales (to M.B.).}, + issn = {0022-3751}, + journal = {JOURNAL OF PHYSIOLOGY-LONDON}, + journal-iso = {J. Physiol.-London}, keywords-plus = {I-H; DENDRITIC INTEGRATION; PLASTICITY; MEMORY; MICE; LTD; NEURONS; PROTEIN; OUTPUT; LOCALIZATION}, - research-areas = {Neurosciences \& Neurology; Physiology}, - web-of-science-categories = {Neurosciences; Physiology}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; Centre National de la Recherche Scientifique - (CNRS); Universite Paris Cite}, - researcherid-numbers = {RINALDI, ARIANNA/AGG-5346-2022 - Garden, Derek/AAB-5908-2020 - Rinaldi, Arianna/F-4713-2018 - Nolan, Matthew F/A-1356-2009 - }, + language = {English}, + month = {NOV 15}, + number = {22}, + number-of-cited-references = {74}, + oa = {Green Published}, orcid-numbers = {RINALDI, ARIANNA/0000-0002-5167-7420 Garden, Derek/0000-0003-3336-3791 Rinaldi, Arianna/0000-0002-5167-7420 Nolan, Matthew F/0000-0003-1062-6501 Beraneck, Mathieu/0000-0003-2722-0532 , Chagla/0000-0002-0867-7337}, - funding-acknowledgement = {Medical Research Council; Marie Curie; NARSAD; Wellcome Trust; Centre - National d'Etudes Spatiales; Medical Research Council {[}G0501216] - Funding Source: researchfish; MRC {[}G0501216] Funding Source: UKRI}, - funding-text = {This study was supported by funding from the Medical Research Council - (to M.F.N.), Marie Curie (to M.F.N.), NARSAD (to M.F.N.) the Wellcome - Trust (to M.F.N.) and Centre National d'Etudes Spatiales (to M.B.).}, - number-of-cited-references = {74}, + pages = {5691-5709}, + publisher = {WILEY}, + research-areas = {Neurosciences \& Neurology; Physiology}, + researcherid-numbers = {RINALDI, ARIANNA/AGG-5346-2022 + Garden, Derek/AAB-5908-2020 + Rinaldi, Arianna/F-4713-2018 + Nolan, Matthew F/A-1356-2009 + }, times-cited = {18}, + title = {HCN1 channels in cerebellar Purkinje cells promote late stages of + learning and constrain synaptic inhibition}, + type = {Article}, + unique-id = {WOS:000326899800023}, usage-count-last-180-days = {0}, usage-count-since-2013 = {7}, - journal-iso = {J. Physiol.-London}, - doc-delivery-number = {251AO}, + volume = {591}, + web-of-science-categories = {Neurosciences; Physiology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000326899800023}, - oa = {Green Published}, - da = {2024-02-13} + year = {2013} } -@article{WOS:000296799700014, - author = {O'Donnell, Cian and Nolan, Matthew F. and van Rossum, Mark C. W.}, - title = {Dendritic Spine Dynamics Regulate the Long-Term Stability of Synaptic - Plasticity}, - journal = {JOURNAL OF NEUROSCIENCE}, - year = {2011}, - volume = {31}, - number = {45}, - pages = {16142-16156}, - month = {NOV 9}, - abstract = {Long-term synaptic plasticity requires postsynaptic influx of Ca(2+) and - is accompanied by changes in dendritic spine size. Unless Ca(2+) influx - mechanisms and spine volume scale proportionally, changes in spine size - will modify spine Ca(2+) concentrations during subsequent synaptic - activation. We show that the relationship between Ca(2+) influx and - spine volume is a fundamental determinant of synaptic stability. If - Ca(2+) influx is undercompensated for increases in spine size, then - strong synapses are stabilized and synaptic strength distributions have - a single peak. In contrast, overcompensation of Ca(2+) influx leads to - binary, persistent synaptic strengths with double-peaked distributions. - Biophysical simulations predict that CA1 pyramidal neuron spines are - undercompensating. This unifies experimental findings that weak synapses - are more plastic than strong synapses, that synaptic strengths are - unimodally distributed, and that potentiation saturates for a given - stimulus strength. We conclude that structural plasticity provides a - simple, local, and general mechanism that allows dendritic spines to - foster both rapid memory formation and persistent memory storage.}, - publisher = {SOC NEUROSCIENCE}, - address = {11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA}, - type = {Article}, +@article{WOS:000346023000009, + abbr = {NOLAN}, + abstract = {Hypertension is associated with pathologically increased sympathetic + drive to the vasculature. This has been attributed to increased + excitatory drive to sympathetic preganglionic neurons (SPN) from + brainstem cardiovascular control centers. However, there is also + evidence supporting increased intrinsic excitability of SPN. To test + this hypothesis, we made whole cell recordings of muscle + vasoconstrictor-like (MVClike) SPN in the working-heart brainstem + preparation of spontaneously hypertensive (SH) and normotensive + Wistar-Kyoto (WKY) rats. The MVClike SPN have a higher spontaneous + firing frequency in the SH rat (3.85 +/- 0.4 vs. 2.44 +/- 0.4 Hz in WKY; + P = 0.011) with greater respiratory modulation of their activity. The + action potentials of SH SPN had smaller, shorter afterhyperpolarizations + (AHPs) and showed diminished transient rectification indicating + suppression of an A-type potassium conductance (I-A). We developed + mathematical models of the SPN to establish if changes in their + intrinsic properties in SH rats could account for their altered firing. + Reduction of the maximal conductance density of I-A by 15-30\% changed + the excitability and output of the model from the WKY to a SH profile, + with increased firing frequency, amplified respiratory modulation, and + smaller AHPs. This change in output is predominantly a consequence of + altered synaptic integration. Consistent with these in silico + predictions, we found that intrathecal 4-aminopyridine (4-AP) increased + sympathetic nerve activity, elevated perfusion pressure, and augmented + Traube-Hering waves. Our findings indicate that I-A acts as a powerful + filter on incoming synaptic drive to SPN and that its diminution in the + SH rat is potentially sufficient to account for the increased + sympathetic output underlying hypertension.}, + address = {9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA}, + affiliation = {Briant, LJB (Corresponding Author), Univ Bristol, Sch Med Sci, Sch Physiol \& Pharmacol, Univ Walk, Bristol BS8 1TD, Avon, England. + Briant, Linford J. B.; Stalbovskiy, Alexey O.; Pickering, Anthony E., Univ Bristol, Sch Physiol \& Pharmacol, Bristol BS8 1TD, Avon, England. + Pickering, Anthony E., Univ Hosp Bristol, Dept Anaesthesia, Bristol, Avon, England. + Champneys, Alan R., Univ Bristol, Dept Engn Math, Bristol BS8 1TD, Avon, England. + Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland.}, + affiliations = {University of Bristol; University of Bristol; University of Bristol; + University of Edinburgh}, + author = {Briant, Linford J. B. and Stalbovskiy, Alexey O. and Nolan, Matthew F. + and Champneys, Alan R. and Pickering, Anthony E.}, + author-email = {Tony.Pickering@Bristol.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {AW1AN}, + doi = {10.1152/jn.00350.2014}, + eissn = {1522-1598}, + funding-acknowledgement = {British Heart Foundation {[}PG/06/084]; Wellcome Trust {[}088373]; + Biotechnology and Biological Sciences Research Council/Engineering; + Physical Sciences Research Council PhD Studentship}, + funding-text = {This study was supported by the British Heart Foundation (Grant + PG/06/084, PI: J. F. R. Paton) and also by The Wellcome Trust (Grant + 088373, PI: A. E. Pickering). L. J. B. Briant is supported by a + Biotechnology and Biological Sciences Research Council/Engineering and + Physical Sciences Research Council PhD Studentship. A. E. Pickering is a + Wellcome Trust Senior Clinical Research fellow.}, + issn = {0022-3077}, + journal = {JOURNAL OF NEUROPHYSIOLOGY}, + journal-iso = {J. Neurophysiol.}, + keywords = {sympathetic preganglionic; vasomotor tone; hypertension; transient + rectification}, + keywords-plus = {DEPENDENT POTASSIUM CURRENTS; TEMPORAL-LOBE EPILEPSY; SPINAL-CORD + INVITRO; MEMBRANE-PROPERTIES; IN-VITRO; ELECTROPHYSIOLOGICAL PROPERTIES; + SYNAPTIC POTENTIALS; PYRAMIDAL NEURONS; BLOOD-PRESSURE; NERVE ACTIVITY}, language = {English}, - affiliation = {O'Donnell, C (Corresponding Author), Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Room 2-51,10 Crichton St, Edinburgh EH8 9AB, Midlothian, Scotland. - O'Donnell, Cian, Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9AB, Midlothian, Scotland. - O'Donnell, Cian; van Rossum, Mark C. W., Univ Edinburgh, Sch Informat, Inst Adapt \& Neural Computat, Edinburgh EH8 9AB, Midlothian, Scotland. - Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1523/JNEUROSCI.2520-11.2011}, - issn = {0270-6474}, - keywords-plus = {TIMING-DEPENDENT PLASTICITY; NEOCORTEX IN-VIVO; ASYMMETRIC HEBBIAN - PLASTICITY; RAT VISUAL-CORTEX; CALCIUM-CHANNELS; HIPPOCAMPAL SYNAPSES; - ULTRASTRUCTURAL ANALYSIS; STRUCTURAL PLASTICITY; NMDA RECEPTORS; ADULT - CORTEX}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {cian.odonnell@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh; University of - Edinburgh}, - researcherid-numbers = {van Rossum, Mark/AAF-6620-2019 - van Rossum, Mark/N-8426-2014 + month = {DEC 1}, + number = {11}, + number-of-cited-references = {65}, + oa = {Green Submitted, Green Published}, + orcid-numbers = {Briant, Linford/0000-0003-3619-3177 + Nolan, Matthew F/0000-0003-1062-6501 + Champneys, Alan/0000-0001-7772-3686 + Pickering, Anthony/0000-0003-0345-0456}, + pages = {2756-2778}, + publisher = {AMER PHYSIOLOGICAL SOC}, + research-areas = {Neurosciences \& Neurology; Physiology}, + researcherid-numbers = {Pickering, Anthony E/A-9929-2011 + Champneys, Alan R/A-2278-2013 + Briant, Linford/O-1205-2019 Nolan, Matthew F/A-1356-2009 }, - orcid-numbers = {van Rossum, Mark/0000-0001-6525-6814 - Nolan, Matthew F/0000-0003-1062-6501 - O'Donnell, Cian/0000-0003-2031-9177}, - funding-acknowledgement = {Medical Research Council; Engineering and Physical Sciences Research - Council; Biotechnology and Biological Sciences Research Council; Human - Frontier Science Program; Marie Curie Excellence grant; BBSRC - {[}BB/H020284/1] Funding Source: UKRI; Biotechnology and Biological - Sciences Research Council {[}BB/H020284/1] Funding Source: researchfish}, - funding-text = {This work was supported by the Medical Research Council (C.O. and - M.F.N.), the Engineering and Physical Sciences Research Council (C.O. - and M. C. W. v. R.), the Biotechnology and Biological Sciences Research - Council (M.F.N.), the Human Frontier Science Program (M. C. W. v. R.), - and a Marie Curie Excellence grant (M.F.N.). We thank Matthias Hennig, - Thomas Oertner, Clare Puddifoot, and Arianna Rinaldi for comments on the - manuscript.}, - number-of-cited-references = {101}, - times-cited = {50}, + times-cited = {10}, + title = {Increased intrinsic excitability of muscle vasoconstrictor preganglionic + neurons may contribute to the elevated sympathetic activity in + hypertensive rats}, + type = {Article}, + unique-id = {WOS:000346023000009}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {16}, - journal-iso = {J. Neurosci.}, - doc-delivery-number = {845CE}, + usage-count-since-2013 = {5}, + volume = {112}, + web-of-science-categories = {Neurosciences; Physiology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000296799700014}, - oa = {hybrid, Green Published}, - da = {2024-02-13} + year = {2014} } -@inproceedings{WOS:000946638602032, - author = {Tam, Wing-Kin and Nolan, Matthew F.}, - book-group-author = {IEEE}, - title = {pyNeurode: a real-time neural signal processing framework}, - booktitle = {2022 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS (ISCAS 22)}, - series = {IEEE International Symposium on Circuits and Systems}, - year = {2022}, - pages = {1943-1947}, - note = {IEEE International Symposium on Circuits and Systems (ISCAS), Austin, - TX, MAY 28-JUN 01, 2022}, - organization = {IEEE; Samsung; Synopsys; Silicon Labs; Mediatek; Cadence; Intel; - Qualcomm; IEEE Circuits \& Syst Soc}, - abstract = {Accurate decoding of neural signals often requires assigning - extracellular waveforms acquired on the same electrode to their - originating neurons, a process known as spike sorting. While many - offline sorters are available, accurate online sorting of spikes with - many channels is still a challenging problem. Existing online sorters - either use simple algorithms with low accuracy, can only process a - handful of channels, or depend on a complex runtime environment that is - difficult to set up. We have developed a state-of-the-art online spike - sorting platform in Python that enables large-scale, fully automatic - real-time spike sorting and decoding on hundreds of channels. Our system - is cross-platform and works seamlessly with the Open Ephys suite of - open-source hardware and software widely used in many neuroscience - laboratories worldwide. It also comes with a user-friendly graphical - user interface to monitor the cluster quality, spike waveforms and - neuronal firing rate. Our platform has comparable accuracy to offline - sorters and can achieve an end-to-end sorting latency of around 160 ms - for 128-channel signals. It will be useful for research in fundamental - neuroscience, closed-loop feedback neuromodulation and brain-computer - interfaces.}, - publisher = {IEEE}, - address = {345 E 47TH ST, NEW YORK, NY 10017 USA}, - type = {Proceedings Paper}, - language = {English}, - affiliation = {Tam, WK (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland. - Tam, WK (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Midlothian, Scotland. - Tam, Wing-Kin; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland. - Tam, Wing-Kin, Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Midlothian, Scotland.}, - doi = {10.1109/ISCAS48785.2022.9937512}, - issn = {0271-4302}, - isbn = {978-1-6654-8485-5}, - keywords = {spike sorting; neural signal processing; braincomputer interface}, - research-areas = {Engineering}, - web-of-science-categories = {Engineering, Electrical \& Electronic}, - author-email = {wtam2@ed.ac.uk - mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh}, - funding-acknowledgement = {Simons Initiative for the Developing Brain}, - funding-text = {This study is supported by the Simons Initiative for the Developing - Brain.}, - number-of-cited-references = {17}, - times-cited = {0}, - usage-count-last-180-days = {0}, - usage-count-since-2013 = {0}, - doc-delivery-number = {BU8EO}, - web-of-science-index = {Conference Proceedings Citation Index - Science (CPCI-S)}, - unique-id = {WOS:000946638602032}, - oa = {Green Submitted}, - da = {2024-02-13} -} - -@article{WOS:000391085500001, - author = {Gonzalez-Sulser, Alfredo and Nolan, Matthew F.}, - title = {Grid cells' need for speed}, - journal = {NATURE NEUROSCIENCE}, - year = {2017}, - volume = {20}, - number = {1}, - pages = {1-2}, - month = {JAN}, - abstract = {Grid-firing fields of neurons in the entorhinal cortex are thought to - require inputs encoding running speed. Glutamatergic projections from - the medial septum may be one of the inputs that provide these speed - signals.}, - publisher = {NATURE PUBLISHING GROUP}, - address = {75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA}, - type = {Editorial Material}, +@article{WOS:000346191500020, + abbr = {NOLAN}, + abstract = {The medial septum (MS) is required for theta rhythmic oscillations and + grid cell firing in the medial entorhinal cortex (MEC). While GABAergic, + glutamatergic, and cholinergic neurons project from the MS to the MEC, + their synaptic targets are unknown. To investigate whether MSneurons + innervate specific layers and cell types in the MEC, we expressed + channelrhodopsin-2 in mouse MSneurons and used patch-clamp recording in + brain slices to determine the response to light activation of identified + cells in the MEC. Following activation of MS axons, we observed fast + monosynaptic GABAergic IPSPs in the majority (>60\%) of fast-spiking + (FS) and low-threshold-spiking (LTS) interneurons in all layers of the + MEC, but in only 1.5\% of nonstellate principal cells (NSPCs) and in no + stellate cells. We also observed fast glutamatergic responses to MS + activation in a minority (<5\%) of NSPCs, FS, and LTS interneurons. + During stimulation of MS inputs at theta frequency (10 Hz), the + amplitude of GABAergic IPSPs was maintained, and spike output from LTS + and FS interneurons was entrained at low (25-60 Hz) and high (60-180 Hz) + gamma frequencies, respectively. By demonstrating cell type-specific + targeting of the GABAergic projection from the MS to the MEC, our + results support the idea that the MS controls theta frequency activity + in the MEC through coordination of inhibitory circuits.}, + address = {11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA}, + affiliation = {Nolan, MF (Corresponding Author), Ctr Integrat Physiol, Hugh Robson Bldg,15 George Sq, Edinburgh EH8 9XD, Midlothian, Scotland. + Gonzalez-Sulser, Alfredo; Parthier, Daniel; Candela, Antonio; McClure, Christina; Pastoll, Hugh; Garden, Derek; Suermeli, Guelsen; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh}, + author = {Gonzalez-Sulser, Alfredo and Parthier, Daniel and Candela, Antonio and + McClure, Christina and Pastoll, Hugh and Garden, Derek and Suermeli, + Guelsen and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {AW3MS}, + doi = {10.1523/JNEUROSCI.1612-14.2014}, + funding-acknowledgement = {Biotechnology and Biological Sciences Research Council (BBSRC) + {[}BB/L010496/1, BB/H020284/1]; Marie-Curie International Incoming + Post-Doctoral Fellowship {[}629586]; Sir Henry Wellcome Postdoctoral + Fellowship {[}098915/Z/12/z]; BBSRC {[}BB/L010496/1, BB/H020284/1] + Funding Source: UKRI; Biotechnology and Biological Sciences Research + Council {[}BB/H020284/1, BB/L010496/1] Funding Source: researchfish; + Wellcome Trust {[}098915/Z/12/Z] Funding Source: Wellcome Trust}, + funding-text = {This work was supported by the Biotechnology and Biological Sciences + Research Council (BBSRC Grants BB/L010496/1 and BB/H020284/1 to M.F.N.), + a Marie-Curie International Incoming Post-Doctoral Fellowship (629586 to + A.G.-S.), and a Sir Henry Wellcome Postdoctoral Fellowship + (098915/Z/12/z to G.S.). We thank the IMPACT facility at the University + of Edinburgh for imaging resources.}, + issn = {0270-6474}, + journal = {JOURNAL OF NEUROSCIENCE}, + journal-iso = {J. Neurosci.}, + keywords = {gamma; interneuron; lamina organization; medial entorhinal cortex; + medial septum; theta}, + keywords-plus = {GAMMA OSCILLATIONS; THETA-RHYTHM; LAYER-II; SPATIAL PERIODICITY; FIRING + FIELDS; GRID CELLS; NEURONS; RAT; HIPPOCAMPUS; AREA}, language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. - Gonzalez-Sulser, Alfredo; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland.}, - doi = {10.1038/nn.4460}, - issn = {1097-6256}, - eissn = {1546-1726}, - keywords-plus = {PROJECTIONS; INTEGRATION; LOCOMOTION}, + month = {DEC 10}, + number = {50}, + number-of-cited-references = {26}, + oa = {Green Published, hybrid}, + orcid-numbers = {Garden, Derek/0000-0003-3336-3791 + Nolan, Matthew F/0000-0003-1062-6501 + Parthier, Daniel/0000-0001-8775-024X + SURMELI, GULSEN/0000-0002-3227-0641 + Gonzalez-Sulser, Alfredo/0000-0003-3494-4029}, + pages = {16739-16743}, + publisher = {SOC NEUROSCIENCE}, research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + researcherid-numbers = {Garden, Derek/AAB-5908-2020 + Surmeli, Gulsen/AAJ-1906-2020 + Core, Vector/CAF-4832-2022 + Nolan, Matthew F/A-1356-2009 }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Gonzalez-Sulser, Alfredo/0000-0003-3494-4029}, - number-of-cited-references = {10}, - times-cited = {2}, + times-cited = {59}, + title = {GABAergic Projections from the Medial Septum Selectively Inhibit + Interneurons in the Medial Entorhinal Cortex}, + type = {Article}, + unique-id = {WOS:000346191500020}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {8}, - journal-iso = {Nat. Neurosci.}, - doc-delivery-number = {EG5LO}, + usage-count-since-2013 = {12}, + volume = {34}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000391085500001}, - oa = {Green Accepted}, - da = {2024-02-13} + year = {2014} } -@article{WOS:000505692200033, - author = {Vandrey, Brianna and Garden, Derek L. F. and Ambrozova, Veronika and - McClure, Christina and Nolan, Matthew F. and Ainge, James A.}, - title = {Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for - Episodic-like Memory}, - journal = {CURRENT BIOLOGY}, - year = {2020}, - volume = {30}, - number = {1}, - pages = {169+}, - month = {JAN 6}, - abstract = {Episodic memory requires different types of information to be bound - together to generate representations of experiences. The lateral - entorhinal cortex (LEC) and hippocampus are required for episodic like - memory in rodents {[}1, 2]. The LEC is critical for integrating spatial - and contextual information about objects {[}236]. Further, LEC neurons - encode objects in the environment and the locations where objects were - previously experienced and generate representations of time during the - encoding and retrieval of episodes {[}7312]. However, it remains unclear - how specific populations of cells within the LEC contribute to the - integration of episodic memory components. Layer 2 (L2) of LEC manifests - early pathology in Alzheimer's disease (AD) and related animal models - {[}13-16]. Projections to the hippocampus from L2 of LEC arise from fan - cells in a superficial sub -layer (L2a) that are immunoreactive for - reelin and project to the dentate gyrus {[}17, 18]. Here, we establish - an approach for selectively targeting fan cells using Siml:Cre mice. - Whereas complete lesions of the LEC were previously found to abolish - associative recognition memory {[}2, 3], we report that, after selective - suppression of synaptic output from fan cells, mice can discriminate - novel object-context configurations but are impaired in recognition of - novel object-place-context associations. Our results suggest that memory - functions are segregated between distinct LEC networks.}, - publisher = {CELL PRESS}, - address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, - type = {Article}, +@article{WOS:000348683800002, + abbr = {NOLAN}, + abstract = {Hippocampal place cells encode an animal's past, current and future + location through sequences of action potentials generated within each + cycle of the network theta rhythm. These sequential representations have + been suggested to result from temporally coordinated synaptic + interactions within and between cell assemblies. Instead, we find + through simulations and analysis of experimental data that rate and + phase coding in independent neurons is sufficient to explain the + organization of CA1 population activity during theta states. We show + that CA1 population activity can be described as an evolving traveling + wave that exhibits phase coding, rate coding, spike sequences and that + generates an emergent population theta rhythm. We identify measures of + global remapping and intracellular theta dynamics as critical for + distinguishing mechanisms for pacemaking and coordination of sequential + population activity. Our analysis suggests that, unlike synaptically + coupled assemblies, independent neurons flexibly generate sequential + population activity within the duration of a single theta cycle.}, + address = {SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND}, + affiliation = {Chadwick, A (Corresponding Author), Univ Edinburgh, Sch Informat, Inst Adapt \& Neural Computat, Edinburgh EH8 9AB, Midlothian, Scotland. + Chadwick, Angus; van Rossum, Mark C. W., Univ Edinburgh, Sch Informat, Inst Adapt \& Neural Computat, Edinburgh EH8 9AB, Midlothian, Scotland. + Chadwick, Angus, Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9AB, Midlothian, Scotland. + Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh; University of + Edinburgh}, + article-number = {e03542}, + author = {Chadwick, Angus and van Rossum, Mark C. W. and Nolan, Matthew F.}, + da = {2024-02-13}, + doc-delivery-number = {CA1PH}, + doi = {10.7554/eLife.03542}, + funding-acknowledgement = {EPSRC; BBSRC; MRC}, + funding-text = {This work was supported by the EPSRC, BBSRC and MRC. We thank Gyuri + Buzsaki, Kamran Diba and Iris Oren for helpful comments on the + manuscript. We are grateful for the provision of experimental data, made + freely available at crcns.org (Mizuseki et al., 2014).}, + issn = {2050-084X}, + journal = {ELIFE}, + journal-iso = {eLife}, + keywords-plus = {HIPPOCAMPAL PLACE CELLS; NETWORK DYNAMICS; PYRAMIDAL CELLS; RUNNING + SPEED; PRECESSION; ASSEMBLIES; CODE; OSCILLATIONS; INHIBITION; FREQUENCY}, language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Hugh Robson Bldg,15 George Sq, Edinburgh EH8 9XE, Midlothian, Scotland. - Ainge, JA (Corresponding Author), Univ St Andrews, Sch Psychol \& Neurosci, South St, St Andrews KY16 9JP, Fife, Scotland. - Vandrey, Brianna; Garden, Derek L. F.; McClure, Christina; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Hugh Robson Bldg,15 George Sq, Edinburgh EH8 9XE, Midlothian, Scotland. - Vandrey, Brianna; Ambrozova, Veronika; Ainge, James A., Univ St Andrews, Sch Psychol \& Neurosci, South St, St Andrews KY16 9JP, Fife, Scotland.}, - doi = {10.1016/j.cub.2019.11.027}, - issn = {0960-9822}, - eissn = {1879-0445}, - keywords-plus = {DENTATE GYRUS; BINDING DEFICITS; OBJECT-CONTEXT; STELLATE CELLS; - NEURONS; PLACE; RECOGNITION; CA3; REPRESENTATION; PARVALBUMIN}, - research-areas = {Biochemistry \& Molecular Biology; Life Sciences \& Biomedicine - Other - Topics; Cell Biology}, - web-of-science-categories = {Biochemistry \& Molecular Biology; Biology; Cell Biology}, - author-email = {matt.nolan@ed.ac.uk - jaa7@st-andrews.ac.uk}, - affiliations = {University of Edinburgh; University of St Andrews}, - researcherid-numbers = {Core, Vector/CAF-4832-2022 - Garden, Derek/AAB-5908-2020 - Nolan, Matthew F/A-1356-2009 - Ainge, James A/D-5831-2012}, - orcid-numbers = {Garden, Derek/0000-0003-3336-3791 + month = {FEB 2}, + number-of-cited-references = {75}, + oa = {Green Published, Green Accepted, gold, Green Submitted}, + orcid-numbers = {van Rossum, Mark/0000-0001-6525-6814 Nolan, Matthew F/0000-0003-1062-6501 - Ainge, James A/0000-0002-0007-1533}, - funding-acknowledgement = {Carnegie Trust; Henry Dryerre scholarship from the Royal Society of - Edinburgh; Wellcome Trust {[}200855/Z/16/Z]; BBSRC {[}BB/M025454/1]; - Wellcome Trust {[}200855/Z/16/Z] Funding Source: Wellcome Trust; BBSRC - {[}BB/M025454/1] Funding Source: UKRI}, - funding-text = {This work was supported by a Carnegie Trust Collaborative Research Grant - to J.A. and M.F.N., a Henry Dryerre scholarship from the Royal Society - of Edinburgh to B.V., and grants from Wellcome Trust (200855/Z/16/Z) and - BBSRC (BB/M025454/1) to M.F.N.}, - number-of-cited-references = {59}, - times-cited = {32}, - usage-count-last-180-days = {1}, - usage-count-since-2013 = {7}, - journal-iso = {Curr. Biol.}, - doc-delivery-number = {KA3IK}, + Chadwick, Angus/0000-0003-2664-0746}, + publisher = {ELIFE SCIENCES PUBLICATIONS LTD}, + research-areas = {Life Sciences \& Biomedicine - Other Topics}, + researcherid-numbers = {van Rossum, Mark/AAF-6620-2019 + Nolan, Matthew F/A-1356-2009 + }, + times-cited = {31}, + title = {Independent Theta Phase Coding Accounts for CA1 Population Sequences and + Enables Flexible Remapping}, + type = {Article}, + unique-id = {WOS:000348683800002}, + usage-count-last-180-days = {0}, + usage-count-since-2013 = {2}, + volume = {4}, + web-of-science-categories = {Biology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000505692200033}, - oa = {Green Published, Green Submitted, hybrid}, - da = {2024-02-13} + year = {2015} } -@article{WOS:000261746700017, - author = {Garden, Derek L. F. and Dodson, Paul D. and O'Donnell, Cian and White, - Melanie D. and Nolan, Matthew F.}, - title = {Tuning of Synaptic Integration in the Medial Entorhinal Cortex to the - Organization of Grid Cell Firing Fields}, - journal = {NEURON}, - year = {2008}, - volume = {60}, - number = {5}, - pages = {875-889}, - month = {DEC 11}, - abstract = {Neurons important for cognitive function are often classified by their - morphology and integrative properties. However, it is unclear if within - a single class of neuron these properties tune synaptic responses to the - salient features of the information that each neuron represents. We - demonstrate that for stellate neurons in layer 11 of the medial - entorhinal cortex, the waveform of postsynaptic potentials, the time - window for detection of coincident inputs, and responsiveness to gamma - frequency inputs follow a dorsal-ventral gradient similar to the - topographical organization of grid-like spatial firing fields of neurons - in this area. We provide evidence that these differences are due to a - membrane conductance gradient mediated by HCN and leak potassium - channels. These findings suggest key roles for synaptic integration in - computations carried out within the medial entorhinal cortex and imply - that tuning of neural information processing by membrane ion channels is - important for normal cognitive function.}, - publisher = {CELL PRESS}, - address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, - type = {Article}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Res Neurosci, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. - Garden, Derek L. F.; Dodson, Paul D.; O'Donnell, Cian; White, Melanie D.; Nolan, Matthew F., Univ Edinburgh, Ctr Res Neurosci, Edinburgh EH8 9XD, Midlothian, Scotland. - Garden, Derek L. F.; Dodson, Paul D.; O'Donnell, Cian; White, Melanie D.; Nolan, Matthew F., Univ Edinburgh, RDSVS, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. - O'Donnell, Cian, Univ Edinburgh, Sch Informat, Inst Adapt \& Neural Computat, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9AB, Midlothian, Scotland.}, - doi = {10.1016/j.neuron.2008.10.044}, - issn = {0896-6273}, - eissn = {1097-4199}, - keywords-plus = {UNION-OF-PHARMACOLOGY; LAYER-II; SUBTHRESHOLD OSCILLATIONS; MOLECULAR - RELATIONSHIPS; HIPPOCAMPAL-FORMATION; POTASSIUM CHANNELS; STELLATE - CELLS; NEURONS; RAT; PROJECTION}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {mattnolan@ed.ac.uk}, +@article{WOS:000349309400021, + abbr = {NOLAN}, + abstract = {Neural circuits in the medial entorhinal cortex (MEC) encode an animal's + position and orientation in space. Within the MEC spatial + representations, including grid and directional firing fields, have a + laminar and dorsoventral organization that corresponds to a similar + topography of neuronal connectivity and cellular properties. Yet, in + part due to the challenges of integrating anatomical data at the + resolution of cortical layers and borders, we know little about the + molecular components underlying this organization. To address this we + develop a new computational pipeline for high-throughput analysis and + comparison of in situ hybridization (ISH) images at laminar resolution. + We apply this pipeline to ISH data for over 16,000 genes in the Allen + Brain Atlas and validate our analysis with RNA sequencing of MEC tissue + from adult mice. We find that differential gene expression delineates + the borders of the MEC with neighboring brain structures and reveals its + laminar and dorsoventral organization. We propose a new molecular basis + for distinguishing the deep layers of the MEC and show that their + similarity to corresponding layers of neocortex is greater than that of + superficial layers. Our analysis identifies ion channel-, cell + adhesion-and synapse-related genes as candidates for functional + differentiation of MEC layers and for encoding of spatial information at + different scales along the dorsoventral axis of the MEC. We also reveal + laminar organization of genes related to disease pathology and suggest + that a high metabolic demand predisposes layer II to neurodegenerative + pathology. In principle, our computational pipeline can be applied to + high-throughput analysis of many forms of neuro-anatomical data. Our + results support the hypothesis that differences in gene expression + contribute to functional specialization of superficial layers of the MEC + and dorsoventral organization of the scale of spatial representations.}, + address = {1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA}, + affiliation = {Ramsden, HL (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. + Ramsden, Helen L.; Suermeli, Guelsen; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. + Ramsden, Helen L., Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Edinburgh, Midlothian, Scotland. + McDonagh, Steven G., Univ Edinburgh, Inst Percept Act \& Behav, Sch Informat, Edinburgh, Midlothian, Scotland. + Nolan, Matthew F., inStem, Ctr Brain Dev \& Repair, Bangalore, Karnataka, India.}, affiliations = {University of Edinburgh; University of Edinburgh; University of - Edinburgh}, - researcherid-numbers = {White, Melanie/J-5565-2019 - Garden, Derek/AAB-5908-2020 - White, Melanie/IAR-3760-2023 - Nolan, Matthew F/A-1356-2009 + Edinburgh; Department of Biotechnology (DBT) India; Institute for Stem + Cell Biology \& Regenerative Medicine - inStem}, + article-number = {e1004032}, + author = {Ramsden, Helen L. and Suermeli, Guelsen and McDonagh, Steven G. and + Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {CB0IO}, + doi = {10.1371/journal.pcbi.1004032}, + eissn = {1553-7358}, + funding-acknowledgement = {Biotechnology and Biological Sciences Research Council {[}BB/L010496/1, + BB/1022147/1]; Engineering and Physical Sciences Research Council + {[}EP/F500385/1, BB/F529254/1]; Wellcome Trust {[}098915/Z/12/Z]; + Wellcome Trust {[}098915/Z/12/Z] Funding Source: Wellcome Trust; BBSRC + {[}BB/L010496/1, BB/I022147/1] Funding Source: UKRI; Biotechnology and + Biological Sciences Research Council {[}BB/I022147/1, BB/L010496/1] + Funding Source: researchfish}, + funding-text = {This work was supported by the Biotechnology and Biological Sciences + Research Council (MFN) (BB/L010496/1 and BB/1022147/1), Engineering and + Physical Sciences Research Council (HR) (EP/F500385/1 and BB/F529254/1) + and Wellcome Trust (GS) (098915/Z/12/Z). The funders had no role in + study design, data collection and analysis, decision to publish, or + preparation of the manuscript.}, + issn = {1553-734X}, + journal = {PLOS COMPUTATIONAL BIOLOGY}, + journal-iso = {PLoS Comput. Biol.}, + keywords-plus = {PREFERENTIAL NEURONAL LOSS; GENOME-WIDE ASSOCIATION; LAYER V NEURONS; + GRID CELLS; ELECTROPHYSIOLOGICAL CHARACTERISTICS; PARAHIPPOCAMPAL + REGION; IDENTIFIES VARIANTS; PYRAMIDAL NEURONS; MOUSE-BRAIN; ADULT}, + language = {English}, + month = {JAN}, + number = {1}, + number-of-cited-references = {103}, + oa = {Green Published, Green Submitted, gold}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + McDonagh, Steven/0000-0001-7025-5197 + SURMELI, GULSEN/0000-0002-3227-0641}, + publisher = {PUBLIC LIBRARY SCIENCE}, + research-areas = {Biochemistry \& Molecular Biology; Mathematical \& Computational Biology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + Surmeli, Gulsen/AAJ-1906-2020 }, - orcid-numbers = {White, Melanie/0000-0002-7399-8348 - Garden, Derek/0000-0003-3336-3791 - Nolan, Matthew F/0000-0003-1062-6501 - O'Donnell, Cian/0000-0003-2031-9177 - Dodson, Paul/0000-0003-0858-6088}, - funding-acknowledgement = {Medical Research Council; Marie Curie Excellence; European Neuroscience - Institutes (ENI-NET); Human Frontier Science Program; EPSRC; Medical - Research Council {[}G0501216] Funding Source: researchfish; MRC - {[}G0501216] Funding Source: UKRI}, - funding-text = {We thank Mayank Dutia and Stephen Williams for comments on an earlier - version of the manuscript, Gareth Leng for statistical advice, and - Jessie vanBinsbergen and Michelle Lew for assistance with - reconstructions. This work was supported by the Medical Research Council - (M.F.N. and C.O'D.), a Marie Curie Excellence grant (M.F.N.), the - network of European Neuroscience Institutes (ENI-NET), a Human Frontier - Science Program long-term fellowship (P.D.D.), and the EPSRC (C.O'D.).}, - number-of-cited-references = {52}, - times-cited = {130}, + times-cited = {37}, + title = {Laminar and Dorsoventral Molecular Organization of the Medial Entorhinal + Cortex Revealed by Large-scale Anatomical Analysis of Gene Expression}, + type = {Article}, + unique-id = {WOS:000349309400021}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {9}, - journal-iso = {Neuron}, - doc-delivery-number = {384LQ}, + usage-count-since-2013 = {14}, + volume = {11}, + web-of-science-categories = {Biochemical Research Methods; Mathematical \& Computational Biology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000261746700017}, - oa = {Green Submitted, hybrid}, - da = {2024-02-13} + year = {2015} } -@article{WOS:000313404600014, - author = {Pastoll, Hugh and Solanka, Lukas and van Rossum, Mark C. W. and Nolan, - Matthew F.}, - title = {Feedback Inhibition Enables Theta-Nested Gamma Oscillations and Grid - Firing Fields}, - journal = {NEURON}, - year = {2013}, - volume = {77}, - number = {1}, - pages = {141-154}, - month = {JAN 9}, - abstract = {Cortical circuits are thought to multiplex firing rate codes with - temporal codes that rely on oscillatory network activity, but the - circuit mechanisms that combine these coding schemes are unclear. We - establish with optogenetic activation of layer II of the medial - entorhinal cortex that theta frequency drive to this circuit is - sufficient to generate nested gamma frequency oscillations in synaptic - activity. These nested gamma oscillations closely resemble activity - during spatial exploration, are generated by local feedback inhibition - without recurrent excitation, and have clock-like features suitable as - reference signals for multiplexing temporal codes within rate-coded grid - firing fields. In network models deduced from our data, feedback - inhibition supports coexistence of theta-nested gamma oscillations with - attractor states that generate grid firing fields. These results - indicate that grid cells communicate primarily via inhibitory - interneurons. This circuit mechanism enables multiplexing of - oscillation-based temporal codes with rate-coded attractor states.}, - publisher = {CELL PRESS}, - address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, - type = {Article}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. - Pastoll, Hugh; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. - Pastoll, Hugh; Solanka, Lukas; van Rossum, Mark C. W., Univ Edinburgh, Sch Informat, Inst Adapt \& Neural Computat, Edinburgh EH8 9AB, Midlothian, Scotland. - Pastoll, Hugh; Solanka, Lukas, Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9AB, Midlothian, Scotland.}, - doi = {10.1016/j.neuron.2012.11.032}, - issn = {0896-6273}, - eissn = {1097-4199}, - keywords-plus = {MEDIAL ENTORHINAL CORTEX; IN-VITRO; SPATIAL PERIODICITY; - PATH-INTEGRATION; RAT; RHYTHM; CELLS; HIPPOCAMPUS; POSITION; MODEL}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {mattnolan@ed.ac.uk}, +@article{WOS:000358250400001, + abbr = {NOLAN}, + abstract = {Neural computations underlying cognitive functions require calibration + of the strength of excitatory and inhibitory synaptic connections and + are associated with modulation of gamma frequency oscillations in + network activity. However, principles relating gamma oscillations, + synaptic strength and circuit computations are unclear. We address this + in attractor network models that account for grid firing and + theta-nested gamma oscillations in the medial entorhinal cortex. We show + that moderate intrinsic noise massively increases the range of synaptic + strengths supporting gamma oscillations and grid computation. With + moderate noise, variation in excitatory or inhibitory synaptic strength + tunes the amplitude and frequency of gamma activity without disrupting + grid firing. This beneficial role for noise results from disruption of + epileptic-like network states. Thus, moderate noise promotes independent + control of multiplexed firing rate-and gamma-based computational + mechanisms. Our results have implications for tuning of normal circuit + function and for disorders associated with changes in gamma oscillations + and synaptic strength.}, + address = {SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. + Solanka, Lukas; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. + Solanka, Lukas; van Rossum, Mark C. W., Inst Adapt \& Neural Computat, Edinburgh, Midlothian, Scotland. + Solanka, Lukas, Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Edinburgh, Midlothian, Scotland.}, affiliations = {University of Edinburgh; University of Edinburgh; University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - van Rossum, Mark/N-8426-2014 - van Rossum, Mark/AAF-6620-2019}, + article-number = {e06444}, + author = {Solanka, Lukas and van Rossum, Mark C. W. and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {CN2KR}, + doi = {10.7554/eLife.06444}, + funding-acknowledgement = {Biotechnology and Biological Sciences Research Council (BBSRC) + {[}BB/L010496/1, BB/F529254/1]; Engineering and Physical Sciences + Research Council (EPSRC) {[}EP/F500385/1]; BBSRC {[}BB/F529254/1, + BB/L010496/1] Funding Source: UKRI; Biotechnology and Biological + Sciences Research Council {[}BB/L010496/1] Funding Source: researchfish}, + funding-text = {Biotechnology and Biological Sciences Research Council (BBSRC) + BB/L010496/1 Lukas Solanka, Matthew F Nolan; Biotechnology and + Biological Sciences Research Council (BBSRC) BB/F529254/1 Lukas Solanka, + Mark CW van Rossum; Engineering and Physical Sciences Research Council + (EPSRC) EP/F500385/1 Lukas Solanka, Mark CW van Rossum}, + issn = {2050-084X}, + journal = {ELIFE}, + journal-iso = {eLife}, + keywords-plus = {ENTORHINAL CORTEX; PARVALBUMIN INTERNEURONS; LAYER-II; MODEL; + MECHANISMS; DYNAMICS; MEMORY; CELLS; RAT; REPRESENTATION}, + language = {English}, + month = {JUL 6}, + number-of-cited-references = {54}, + oa = {Green Submitted, Green Published, gold}, orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - van Rossum, Mark/0000-0001-6525-6814}, - funding-acknowledgement = {Biotechnology and Biological Sciences Research Council; Engineering and - Physical Sciences Research Council; Commonwealth Scholarships - Commission; Biotechnology and Biological Sciences Research Council - {[}BB/H020284/1] Funding Source: researchfish; BBSRC {[}BB/H020284/1] - Funding Source: UKRI}, - funding-text = {This work was supported by the Biotechnology and Biological Sciences - Research Council (M.F.N.), the Engineering and Physical Sciences - Research Council (H.P. and L.S.), and the Commonwealth Scholarships - Commission (H.P.). We thank Ian Duguid for comments on the manuscript - and Patrick Kaifosh for suggestions about network configurations. This - work made use of resources provided by the Edinburgh Compute and Data - Facility. H.P. contributed to design of the study and performed and - analyzed experiments. L.S. contributed to design of the study and - performed and analyzed simulations. M.C.W.v.R. contributed to design of - the study and analysis of simulations. M.F.N. designed and supervised - the study, contributed to data analysis, and wrote the manuscript.}, - number-of-cited-references = {48}, - times-cited = {199}, - usage-count-last-180-days = {1}, - usage-count-since-2013 = {53}, - journal-iso = {Neuron}, - doc-delivery-number = {068ZL}, + van Rossum, Mark CW/0000-0001-6525-6814}, + publisher = {ELIFE SCIENCES PUBLICATIONS LTD}, + research-areas = {Life Sciences \& Biomedicine - Other Topics}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + }, + times-cited = {16}, + title = {Noise promotes independent control of gamma oscillations and grid firing + within recurrent attractor networks}, + type = {Article}, + unique-id = {WOS:000358250400001}, + usage-count-last-180-days = {0}, + usage-count-since-2013 = {9}, + volume = {4}, + web-of-science-categories = {Biology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000313404600014}, - oa = {Green Accepted, Bronze, Green Submitted}, - da = {2024-02-13} + year = {2015} } -@article{WOS:000878031400006, - author = {Tennant, Sarah A. and Clark, Harry and Hawes, Ian and Tam, Wing Kin and - Hua, Junji and Yang, Wannan and Gerlei, Klara Z. and Wood, Emma R. and - Nolan, Matthew F.}, - title = {Spatial representation by ramping activity of neurons in the - retrohippocampal cortex}, - journal = {CURRENT BIOLOGY}, - year = {2022}, - volume = {32}, - number = {20}, - pages = {4451+}, - month = {OCT 24}, - abstract = {Neurons in the retrohippocampal cortices play crucial roles in spatial - memory. Many retrohippocampal neu-rons have firing fields that are - selectively active at specific locations, with memory for rewarded - locations associated with reorganization of these firing fields. Whether - this is the sole strategy for representing spatial memories is unclear. - Here, we demonstrate that during a spatial memory task retrohippocampal - neurons encode location through ramping activity that extends across - segments of a linear track approaching and following a reward, with the - rewarded location represented by offsets or switches in the slope of the - ramping activity. Ramping representations could be maintained - independently of trial outcome and cues marking the reward location, - indicating that they result from recall of the track structure. When - recorded in an open arena, neurons that generated ramping activity - during the spatial memory task were more numerous than grid or border - cells, with a majority showing spatial firing that did not meet criteria - for classification as grid or border representations. Encoding of - rewarded locations through offsets and switches in the slope of ramping - activ-ity also emerged in recurrent neural network models trained to - solve a similar spatial memory task. Impaired performance of model - networks following disruption of outputs from ramping neurons is - consistent with this coding strategy supporting navigation to recalled - locations of behavioral significance. Our results suggest that encoding - of learned spaces by retrohippocampal networks employs both discrete - firing fields and continuous ramping representations. We hypothesize - that retrohippocampal ramping activity mediates readout of learned - models for goal-directed navigation.}, - publisher = {CELL PRESS}, +@article{WOS:000365766500020, + abbr = {NOLAN}, + abstract = {Deep layers of the medial entorhinal cortex are considered to relay + signals from the hippocampus to other brain structures, but pathways for + routing of signals to and from the deep layers are not well established. + Delineating these pathways is important for a circuit level + understanding of spatial cognition and memory. We find that neurons in + layers 5a and 5b have distinct molecular identities, defined by the + transcription factors Etv1 and Ctip2, and divergent targets, with + extensive intratelencephalic projections originating in layer 5a, but + not 5b. This segregation of outputs is mirrored by the organization of + glutamatergic input from stellate cells in layer 2 and from the + hippocampus, with both preferentially targeting layer 5b over 5a. Our + results suggest a molecular and anatomical organization of input-output + computations in deep layers of the MEC, reveal precise translaminar + microcircuitry, and identify molecularly defined pathways for spatial + signals to influence computation in deep layers.}, address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, - type = {Article}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Scotland. - Nolan, MF (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Scotland. - Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Stat, Edinburgh, Scotland. - Tennant, Sarah A.; Clark, Harry; Hawes, Ian; Tam, Wing Kin; Hua, Junji; Yang, Wannan; Gerlei, Klara Z.; Wood, Emma R.; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Scotland. - Tam, Wing Kin; Wood, Emma R.; Nolan, Matthew F., Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Scotland. - Nolan, Matthew F., Univ Edinburgh, Ctr Stat, Edinburgh, Scotland. - Yang, Wannan, NYU, Ctr Neural Sci, New York, NY USA.}, - doi = {10.1016/j.cub.2022.08.050}, - earlyaccessdate = {OCT 2022}, - issn = {0960-9822}, - eissn = {1879-0445}, - keywords-plus = {ENTORHINAL CORTEX; VENTRAL STRIATUM; SPEED CELLS; GRID CELLS; GAMMA - OSCILLATIONS; PLACE CELLS; HIPPOCAMPUS; NAVIGATION; MAP; INFORMATION}, - research-areas = {Biochemistry \& Molecular Biology; Life Sciences \& Biomedicine - Other - Topics; Cell Biology}, - web-of-science-categories = {Biochemistry \& Molecular Biology; Biology; Cell Biology}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. + Surmeli, Gulsen; Marcu, Daniel Cosmin; McClure, Christina; Garden, Derek L. F.; Pastoll, Hugh; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh}, + author = {Surmeli, Gulsen and Marcu, Daniel Cosmin and McClure, Christina and + Garden, Derek L. F. and Pastoll, Hugh and Nolan, Matthew F.}, author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh; University of - Edinburgh; New York University}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009}, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501}, - funding-acknowledgement = {Wellcome Trust {[}108890/Z/15/Z, 200855/Z/16/Z]; BBSRC {[}BB/L010496/1]; - Simons Initiative for the Developing Brain; College of Medicine and - Veterinary Medicine PhD Studentship - Thomas Work Fellowship; Medical - Research Council Precision Medicine PhD programme; Wellcome Trust - {[}200855/Z/16/Z] Funding Source: Wellcome Trust}, - funding-text = {We thank Richard Morris for feedback on an earlier version of the - manuscript, Robert Wallace for assistance with micro-CT imaging, Holly - Stevens for technical assistance, and Gulsxen Surmeli, Ian Duguid, and - members of the Surmeli, Duguid, and Nolan labs for helpful discussions. - This work was supported by grants to M.F.N. from the Wellcome Trust - (200855/Z/16/Z), the BBSRC (BB/L010496/1), and the Simons Initiative for - the Developing Brain; by a College of Medicine and Veterinary Medicine - PhD Studentship, funded by the Thomas Work Fellowship, to K.Z.G.; by the - Wellcome Trust (108890/Z/15/Z) Translational Neuroscience PhD programme - to I.H.; and by the Medical Research Council Precision Medicine PhD - programme to H.C. This work made use of resources provided by the - Edinburgh Compute and Data Facility. For the purpose of open access, the - author has applied a CC BY public copyright license to any Author - Accepted Manuscript version arising from this submission.}, - number-of-cited-references = {87}, - times-cited = {0}, + da = {2024-02-13}, + doc-delivery-number = {CX5TX}, + doi = {10.1016/j.neuron.2015.10.041}, + eissn = {1097-4199}, + funding-acknowledgement = {Biotechnology and Biological Sciences Research Council {[}BB/L010496/1, + BB/1022147/1]; Sir Henry Wellcome Fellowship {[}098915/Z/12/Z]; + Biotechnology and Biological Sciences Research Council {[}BB/L010496/1, + BB/I022147/1] Funding Source: researchfish; BBSRC {[}BB/I022147/1, + BB/L010496/1] Funding Source: UKRI; Wellcome Trust {[}098915/Z/12/Z] + Funding Source: Wellcome Trust}, + funding-text = {We thank Ian Duguid, Nathalie Rochefort, and Alfredo Gonzalez-Sulser for + their comments on the manuscript. We also thank Mark Robertson, Grant + Marshall, Julia Schiemann, and Kimberly Ritola-Hantman for technical + help and Thomas Jessell, Susan Morton, and Thomas Kuner for reagents. + This work was supported by the Biotechnology and Biological Sciences + Research Council (M.F.N.) (BB/L010496/1 and BB/1022147/1) and a Sir + Henry Wellcome Fellowship (GS) (098915/Z/12/Z). The funders had no role + in study design, data collection and analysis, decision to publish, or + preparation of the manuscript.}, + issn = {0896-6273}, + journal = {NEURON}, + journal-iso = {Neuron}, + keywords-plus = {PROJECTION NEURONS; PARAHIPPOCAMPAL REGION; GRID CELLS; RAT; + ORGANIZATION; CONNECTIONS; EXPRESSION; ORIGIN; REPRESENTATION; + SPECIFICATION}, + language = {English}, + month = {DEC 2}, + number = {5}, + number-of-cited-references = {46}, + oa = {Green Published, hybrid}, + orcid-numbers = {Garden, Derek/0000-0003-3336-3791 + Nolan, Matthew F/0000-0003-1062-6501 + SURMELI, GULSEN/0000-0002-3227-0641 + Marcu, Daniel-Cosmin/0000-0002-1006-3094}, + pages = {1040-1053}, + publisher = {CELL PRESS}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {Core, Vector/CAF-4832-2022 + Surmeli, Gulsen/AAJ-1906-2020 + Garden, Derek/AAB-5908-2020 + Nolan, Matthew F/A-1356-2009 + }, + times-cited = {65}, + title = {Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep + Layers of the Medial Entorhinal Cortex}, + type = {Article}, + unique-id = {WOS:000365766500020}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {8}, - journal-iso = {Curr. Biol.}, - doc-delivery-number = {5W6OP}, + usage-count-since-2013 = {15}, + volume = {88}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000878031400006}, - oa = {Green Accepted, Green Published, hybrid}, - da = {2024-02-13} + year = {2015} } -@article{WOS:000394581400027, - author = {Garden, Derek L. F. and Rinaldi, Arianna and Nolan, Matthew F.}, - title = {Active integration of glutamatergic input to the inferior olive - generates bidirectional postsynaptic potentials}, - journal = {JOURNAL OF PHYSIOLOGY-LONDON}, - year = {2017}, - volume = {595}, - number = {4}, - pages = {1239-1251}, - month = {FEB}, - abstract = {The inferior olive plays a critical role in motor coordination and - learning by integrating diverse afferent signals to generate climbing - fibre inputs to the cerebellar cortex. While it is well established that - climbing fibre signals are important for motor coordination, the - mechanisms by which neurones in the inferior olive integrate synaptic - inputs and the roles of particular ion channels are unclear. Here, we - test the hypothesis that neurones in the inferior olive actively - integrate glutamatergic synaptic inputs. We demonstrate that - optogenetically activated long-range synaptic inputs to the inferior - olive, including projections from the motor cortex, generate rapid - excitatory potentials followed by slower inhibitory potentials. Synaptic - projections from the motor cortex preferentially target the principal - olivary nucleus. We show that inhibitory and excitatory components of - the bidirectional synaptic potentials are dependent upon AMPA (GluA) - receptors, are GABA(A) independent, and originate from the same - presynaptic axons. Consistent with models that predict active - integration of synaptic inputs by inferior olive neurones, we find that - the inhibitory component is reduced by blocking large conductance - calcium-activated potassium channels with iberiotoxin, and is abolished - by blocking small conductance calcium-activated potassium channels with - apamin. Summation of excitatory components of synaptic responses to - inputs at intervals 20ms is increased by apamin, suggesting a role for - the inhibitory component of glutamatergic responses in temporal - integration. Our results indicate that neurones in the inferior olive - implement novel rules for synaptic integration and suggest new - principles for the contribution of inferior olive neurones to - coordinated motor behaviours.}, - publisher = {WILEY}, +@article{WOS:000379804700002, + abbr = {NOLAN}, address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, - type = {Article}, - language = {English}, affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. - Garden, Derek L. F.; Rinaldi, Arianna; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1113/JP273424}, - issn = {0022-3751}, + Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh}, + author = {Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {DR3LM}, + doi = {10.1113/JP272673}, eissn = {1469-7793}, - keywords = {inferior olive; ion channel; synaptic integration}, - keywords-plus = {ELECTROPHYSIOLOGICAL PROPERTIES; MOTOR-CORTEX; SK CHANNELS; IN-VITRO; - NEURONS; OSCILLATIONS; MODULATION; CAT; ACTIVATION; PROJECTION}, + funding-acknowledgement = {BBSRC {[}BB/L010496/1] Funding Source: UKRI; Biotechnology and + Biological Sciences Research Council {[}BB/L010496/1] Funding Source: + researchfish}, + issn = {0022-3751}, + journal = {JOURNAL OF PHYSIOLOGY-LONDON}, + journal-iso = {J. Physiol.-London}, + keywords-plus = {CURRENTS}, + language = {English}, + month = {JUL 1}, + number = {13}, + number-of-cited-references = {7}, + oa = {Green Published, hybrid}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501}, + pages = {3487-3488}, + publisher = {WILEY-BLACKWELL}, research-areas = {Neurosciences \& Neurology; Physiology}, - web-of-science-categories = {Neurosciences; Physiology}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh}, - researcherid-numbers = {Rinaldi, Arianna/F-4713-2018 - RINALDI, ARIANNA/AGG-5346-2022 - Nolan, Matthew F/A-1356-2009 - Garden, Derek/AAB-5908-2020}, - orcid-numbers = {Rinaldi, Arianna/0000-0002-5167-7420 - RINALDI, ARIANNA/0000-0002-5167-7420 - Nolan, Matthew F/0000-0003-1062-6501 - Garden, Derek/0000-0003-3336-3791}, - funding-acknowledgement = {Medical Research Council {[}G0501216]; Wellcome Trust {[}093295/Z/10/Z]; - BBSRC {[}Bb/H020284/1]; BBSRC {[}BB/H020284/1] Funding Source: UKRI; MRC - {[}G0501216] Funding Source: UKRI; Biotechnology and Biological Sciences - Research Council {[}BB/H020284/1] Funding Source: researchfish; Medical - Research Council {[}G0501216] Funding Source: researchfish; Wellcome - Trust {[}093295/Z/10/Z] Funding Source: Wellcome Trust}, - funding-text = {This work was supported by the Medical Research Council (G0501216), the - Wellcome Trust (093295/Z/10/Z) and the BBSRC (Bb/H020284/1).}, - number-of-cited-references = {43}, - times-cited = {9}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009}, + times-cited = {0}, + title = {Local field potentials get funny}, + type = {Editorial Material}, + unique-id = {WOS:000379804700002}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {3}, - journal-iso = {J. Physiol.-London}, - doc-delivery-number = {EL4HD}, + usage-count-since-2013 = {4}, + volume = {594}, + web-of-science-categories = {Neurosciences; Physiology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000394581400027}, - oa = {hybrid, Green Published}, - da = {2024-02-13} + year = {2016} } -@article{WOS:000281389500018, - author = {Cannon, Robert C. and O'Donnell, Cian and Nolan, Matthew F.}, - title = {Stochastic Ion Channel Gating in Dendritic Neurons: Morphology - Dependence and Probabilistic Synaptic Activation of Dendritic Spikes}, - journal = {PLOS COMPUTATIONAL BIOLOGY}, - year = {2010}, - volume = {6}, - number = {8}, - month = {AUG}, - abstract = {Neuronal activity is mediated through changes in the probability of - stochastic transitions between open and closed states of ion channels. - While differences in morphology define neuronal cell types and may - underlie neurological disorders, very little is known about influences - of stochastic ion channel gating in neurons with complex morphology. We - introduce and validate new computational tools that enable efficient - generation and simulation of models containing stochastic ion channels - distributed across dendritic and axonal membranes. Comparison of five - morphologically distinct neuronal cell types reveals that when all - simulated neurons contain identical densities of stochastic ion - channels, the amplitude of stochastic membrane potential fluctuations - differs between cell types and depends on sub-cellular location. For - typical neurons, the amplitude of membrane potential fluctuations - depends on channel kinetics as well as open probability. Using a - detailed model of a hippocampal CA1 pyramidal neuron, we show that when - intrinsic ion channels gate stochastically, the probability of - initiation of dendritic or somatic spikes by dendritic synaptic input - varies continuously between zero and one, whereas when ion channels gate - deterministically, the probability is either zero or one. At - physiological firing rates, stochastic gating of dendritic ion channels - almost completely accounts for probabilistic somatic and dendritic - spikes generated by the fully stochastic model. These results suggest - that the consequences of stochastic ion channel gating differ globally - between neuronal cell-types and locally between neuronal compartments. - Whereas dendritic neurons are often assumed to behave deterministically, - our simulations suggest that a direct consequence of stochastic gating - of intrinsic ion channels is that spike output may instead be a - probabilistic function of patterns of synaptic input to dendrites.}, - publisher = {PUBLIC LIBRARY SCIENCE}, - address = {1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA}, - type = {Article}, - language = {English}, - affiliation = {Cannon, RC (Corresponding Author), Textensor Ltd, Edinburgh, Midlothian, Scotland. - Cannon, Robert C., Textensor Ltd, Edinburgh, Midlothian, Scotland. - O'Donnell, Cian, Univ Edinburgh, Neuroinformat Doctoral Training Ctr, Edinburgh, Midlothian, Scotland. - Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland.}, - doi = {10.1371/journal.pcbi.1000886}, - article-number = {e1000886}, - issn = {1553-734X}, - eissn = {1553-7358}, - keywords-plus = {ACTION-POTENTIALS; INTEGRATIVE PROPERTIES; CURRENT FLUCTUATIONS; - PYRAMIDAL NEURONS; K+ CHANNELS; PROPAGATION; MEMBRANE; NOISE; - SIMULATION; CONDUCTANCE}, - research-areas = {Biochemistry \& Molecular Biology; Mathematical \& Computational Biology}, - web-of-science-categories = {Biochemical Research Methods; Mathematical \& Computational Biology}, +@article{WOS:000388572700024, + abbr = {NOLAN}, + address = {600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA}, + author = {Surmeli, Gulsen and Marcu, Daniel Cosmin and McClure, Christina and + Garden, Derek L. F. and Pastoll, Hugh and Nolan, Matthew F.}, author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - }, + da = {2024-02-13}, + doc-delivery-number = {ED0ZH}, + doi = {10.1016/j.neuron.2016.11.011}, + eissn = {1097-4199}, + issn = {0896-6273}, + journal = {NEURON}, + journal-iso = {Neuron}, + language = {English}, + month = {NOV 23}, + number = {4}, + number-of-cited-references = {1}, + oa = {Green Published, hybrid}, orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - O'Donnell, Cian/0000-0003-2031-9177}, - funding-acknowledgement = {BBSRC {[}BB/E014527/1]; Marie Curie Excellence; Network of European - Neuroscience Institutes; EPSRC; eDIKT initiative; Biotechnology and - Biological Sciences Research Council {[}BB/E014526/1] Funding Source: - researchfish; BBSRC {[}BB/E014526/1] Funding Source: UKRI}, - funding-text = {This work was supported by a BBSRC Tools and Resources Fund award - (BB/E014527/1 to MFN), a Marie Curie Excellence grant (MFN), the Network - of European Neuroscience Institutes (http://www.eni-net.org/) and the - EPSRC (C'OD). This work has made use of the resources provided by the - ECDF (http://www.ecdf.ed.ac.uk/). The ECDF is partially supported by the - eDIKT initiative (http://www.edikt.org.uk). The funders had no role in - study design, data collection and analysis, decision to publish, or - preparation of the manuscript.}, - number-of-cited-references = {72}, - times-cited = {57}, - usage-count-last-180-days = {0}, - usage-count-since-2013 = {9}, - journal-iso = {PLoS Comput. Biol.}, - doc-delivery-number = {644OU}, + Garden, Derek/0000-0003-3336-3791 + Marcu, Daniel-Cosmin/0000-0002-1006-3094 + SURMELI, GULSEN/0000-0002-3227-0641}, + pages = {929}, + publisher = {CELL PRESS}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {Surmeli, Gulsen/AAJ-1906-2020 + Nolan, Matthew F/A-1356-2009 + Garden, Derek/AAB-5908-2020 + }, + times-cited = {9}, + title = {Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep + Layers of the Medial Entorhinal Cortex (vol 88, pg 1040, 2015)}, + type = {Correction}, + unique-id = {WOS:000388572700024}, + usage-count-last-180-days = {1}, + usage-count-since-2013 = {4}, + volume = {92}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000281389500018}, - oa = {Green Published, gold}, - da = {2024-02-13} + year = {2016} } -@article{WOS:000209370100006, - author = {White, Melanie D. and Milne, Ruth V. J. and Nolan, Matthew F.}, - title = {A molecular toolbox for rapid generation of viral vectors to up- or - down-regulate neuronal gene expression in vivo}, - journal = {FRONTIERS IN MOLECULAR NEUROSCIENCE}, - year = {2011}, - volume = {4}, - abstract = {We introduce a molecular toolbox for manipulation of neuronal gene - expression in vivo. The toolbox includes promoters, ion channels, - optogenetic tools, fluorescent proteins, and intronic artificial - microRNAs. The components are easily assembled into adeno-associated - virus (AAV) or lentivirus vectors using recombination cloning. We - demonstrate assembly of toolbox components into lentivirus and AAV - vectors and use these vectors for in vivo expression of inwardly - rectifying potassium channels (Kir2.1, Kir3.1, and Kir3.2) and an - artificial microRNA targeted against the ion channel HCN1 (HCN1 miRNA). - We show that AAV assembled to express HCN1 miRNA produces efficacious - and specific in vivo knockdown of HCN1 channels. Comparison of in vivo - viral transduction using HCN1 miRNA with mice containing a germ line - deletion of HCN1 reveals similar physiological phenotypes in cerebellar - Purkinje cells. The easy assembly and re-usability of the toolbox - components, together with the ability to up- or down-regulate neuronal - gene expression in vivo, may be useful for applications in many areas of - neuroscience.}, - publisher = {FRONTIERS MEDIA SA}, - address = {AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND}, - type = {Article}, - language = {English}, +@article{WOS:000389029900005, + abbr = {NOLAN}, + address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. - White, Melanie D.; Milne, Ruth V. J.; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.3389/fnmol.2011.00008}, - article-number = {8}, - issn = {1662-5099}, - keywords = {intronic miRNA; ion channel; lentivirus; AAV; RNAi; hippocampus; - cerebellum; virus}, - keywords-plus = {LENTIVIRAL VECTORS; HCN1 CHANNELS; HOMOLOGOUS RECOMBINATION; - ADENOASSOCIATED VIRUS; TRANSGENE EXPRESSION; CORTICAL-NEURONS; RNA - INTERFERENCE; DNA CLONING; PROTEIN; BRAIN}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {mattnolan@ed.ac.uk}, + Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, affiliations = {University of Edinburgh}, - researcherid-numbers = {White, Melanie/J-5565-2019 - White, Melanie/IAR-3760-2023 - Nolan, Matthew F/A-1356-2009}, - orcid-numbers = {White, Melanie/0000-0002-7399-8348 - Nolan, Matthew F/0000-0003-1062-6501}, - funding-acknowledgement = {Marie Curie Excellence Grant; BBSRC; MRC; NARSAD; BBSRC {[}BB/H020284/1] - Funding Source: UKRI; MRC {[}G0501216] Funding Source: UKRI; - Biotechnology and Biological Sciences Research Council {[}BB/H020284/1] - Funding Source: researchfish; Medical Research Council {[}G0501216] - Funding Source: researchfish}, - funding-text = {We thank Trudi Gillespi from the IMPACT Imaging facility at the - University of Edinburgh for assistance with confocal microscopy and Bina - Santoro, Hiroyuki Hioki, Patrick Martin, Axel Schambach, and Guangwei Du - for generously providing plasmids. This work was funded by a Marie Curie - Excellence Grant and grants from the BBSRC, the MRC, and NARSAD.}, - number-of-cited-references = {49}, - times-cited = {30}, + author = {Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {ED7GI}, + doi = {10.1113/JP273087}, + eissn = {1469-7793}, + funding-acknowledgement = {Biotechnology and Biological Sciences Research Council {[}BB/L010496/1] + Funding Source: researchfish; BBSRC {[}BB/L010496/1] Funding Source: + Medline; BBSRC {[}BB/L010496/1] Funding Source: UKRI}, + issn = {0022-3751}, + journal = {JOURNAL OF PHYSIOLOGY-LONDON}, + journal-iso = {J. Physiol.-London}, + keywords-plus = {ENTORHINAL CORTEX; HEAD-DIRECTION; GRID CELLS}, + language = {English}, + month = {NOV 15}, + number = {22}, + number-of-cited-references = {23}, + oa = {Green Published, hybrid}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501}, + pages = {6487-6488}, + publisher = {WILEY-BLACKWELL}, + research-areas = {Neurosciences \& Neurology; Physiology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009}, + times-cited = {0}, + title = {Neural mechanisms for spatial computation}, + type = {Editorial Material}, + unique-id = {WOS:000389029900005}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {5}, - journal-iso = {Front. Molec. Neurosci.}, - doc-delivery-number = {V38VE}, + usage-count-since-2013 = {2}, + volume = {594}, + web-of-science-categories = {Neurosciences; Physiology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000209370100006}, - oa = {Green Published, gold}, - da = {2024-02-13} + year = {2016} } -@article{WOS:000346023000009, - author = {Briant, Linford J. B. and Stalbovskiy, Alexey O. and Nolan, Matthew F. - and Champneys, Alan R. and Pickering, Anthony E.}, - title = {Increased intrinsic excitability of muscle vasoconstrictor preganglionic - neurons may contribute to the elevated sympathetic activity in - hypertensive rats}, - journal = {JOURNAL OF NEUROPHYSIOLOGY}, - year = {2014}, - volume = {112}, - number = {11}, - pages = {2756-2778}, - month = {DEC 1}, - abstract = {Hypertension is associated with pathologically increased sympathetic - drive to the vasculature. This has been attributed to increased - excitatory drive to sympathetic preganglionic neurons (SPN) from - brainstem cardiovascular control centers. However, there is also - evidence supporting increased intrinsic excitability of SPN. To test - this hypothesis, we made whole cell recordings of muscle - vasoconstrictor-like (MVClike) SPN in the working-heart brainstem - preparation of spontaneously hypertensive (SH) and normotensive - Wistar-Kyoto (WKY) rats. The MVClike SPN have a higher spontaneous - firing frequency in the SH rat (3.85 +/- 0.4 vs. 2.44 +/- 0.4 Hz in WKY; - P = 0.011) with greater respiratory modulation of their activity. The - action potentials of SH SPN had smaller, shorter afterhyperpolarizations - (AHPs) and showed diminished transient rectification indicating - suppression of an A-type potassium conductance (I-A). We developed - mathematical models of the SPN to establish if changes in their - intrinsic properties in SH rats could account for their altered firing. - Reduction of the maximal conductance density of I-A by 15-30\% changed - the excitability and output of the model from the WKY to a SH profile, - with increased firing frequency, amplified respiratory modulation, and - smaller AHPs. This change in output is predominantly a consequence of - altered synaptic integration. Consistent with these in silico - predictions, we found that intrathecal 4-aminopyridine (4-AP) increased - sympathetic nerve activity, elevated perfusion pressure, and augmented - Traube-Hering waves. Our findings indicate that I-A acts as a powerful - filter on incoming synaptic drive to SPN and that its diminution in the - SH rat is potentially sufficient to account for the increased - sympathetic output underlying hypertension.}, - publisher = {AMER PHYSIOLOGICAL SOC}, - address = {9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA}, - type = {Article}, +@article{WOS:000389029900011, + abbr = {NOLAN}, + abstract = {Neurons in the medial entorhinal cortex encode location through spatial + firing fields that have a grid-like organisation. The challenge of + identifying mechanisms for grid firing has been addressed through + experimental and theoretical investigations of medial entorhinal + circuits. Here, we discuss evidence for continuous attractor network + models that account for grid firing by synaptic interactions between + excitatory and inhibitory cells. These models assume that grid-like + firing patterns are the result of computation of location from velocity + inputs, with additional spatial input required to oppose drift in the + attractor state. We focus on properties of continuous attractor networks + that are revealed by explicitly considering excitatory and inhibitory + neurons, their connectivity and their membrane potential dynamics. + Models at this level of detail can account for theta-nested gamma + oscillations as well as grid firing, predict spatial firing of + interneurons as well as excitatory cells, show how gamma oscillations + can bemodulated independently from spatial computations, reveal critical + roles for neuronal noise, and demonstrate that only a subset of + excitatory cells in a network need have grid-like firing fields. + Evaluating experimental data against predictions from detailed network + models will be important for establishing the mechanisms mediating grid + firing.}, + address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. + Shipston-Sharman, Oliver; Solanka, Lukas; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh}, + author = {Shipston-Sharman, Oliver and Solanka, Lukas and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {ED7GI}, + doi = {10.1113/JP270630}, + eissn = {1469-7793}, + funding-acknowledgement = {BBSRC {[}Bb/L010496/1, Bb/1022147/1]; Biotechnology and Biological + Sciences Research Council {[}BB/L010496/1, BB/I022147/1] Funding Source: + researchfish; BBSRC {[}BB/L010496/1, BB/I022147/1] Funding Source: UKRI}, + funding-text = {This work was supported by grants to M.F.N. from the BBSRC (Bb/L010496/1 + and Bb/1022147/1).}, + issn = {0022-3751}, + journal = {JOURNAL OF PHYSIOLOGY-LONDON}, + journal-iso = {J. Physiol.-London}, + keywords-plus = {ENTORHINAL CORTEX; PATH-INTEGRATION; GAMMA OSCILLATIONS; PHASE + PRECESSION; LAYER-II; DYNAMICS; INTERNEURONS; MECHANISMS; + REPRESENTATION; INTERFERENCE}, language = {English}, - affiliation = {Briant, LJB (Corresponding Author), Univ Bristol, Sch Med Sci, Sch Physiol \& Pharmacol, Univ Walk, Bristol BS8 1TD, Avon, England. - Briant, Linford J. B.; Stalbovskiy, Alexey O.; Pickering, Anthony E., Univ Bristol, Sch Physiol \& Pharmacol, Bristol BS8 1TD, Avon, England. - Pickering, Anthony E., Univ Hosp Bristol, Dept Anaesthesia, Bristol, Avon, England. - Champneys, Alan R., Univ Bristol, Dept Engn Math, Bristol BS8 1TD, Avon, England. - Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland.}, - doi = {10.1152/jn.00350.2014}, - issn = {0022-3077}, - eissn = {1522-1598}, - keywords = {sympathetic preganglionic; vasomotor tone; hypertension; transient - rectification}, - keywords-plus = {DEPENDENT POTASSIUM CURRENTS; TEMPORAL-LOBE EPILEPSY; SPINAL-CORD - INVITRO; MEMBRANE-PROPERTIES; IN-VITRO; ELECTROPHYSIOLOGICAL PROPERTIES; - SYNAPTIC POTENTIALS; PYRAMIDAL NEURONS; BLOOD-PRESSURE; NERVE ACTIVITY}, + month = {NOV 15}, + number = {22}, + number-of-cited-references = {57}, + oa = {Green Published, Green Accepted, hybrid}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Shipston-Sharman, Oliver/0000-0002-6529-1537}, + pages = {6547-6557}, + publisher = {WILEY}, research-areas = {Neurosciences \& Neurology; Physiology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + Shipston-Sharman, Oliver/Q-5431-2018}, + times-cited = {38}, + title = {Continuous attractor network models of grid cell firing based on + excitatory-inhibitory interactions}, + type = {Review}, + unique-id = {WOS:000389029900011}, + usage-count-last-180-days = {1}, + usage-count-since-2013 = {24}, + volume = {594}, web-of-science-categories = {Neurosciences; Physiology}, - author-email = {Tony.Pickering@Bristol.ac.uk}, - affiliations = {University of Bristol; University of Bristol; University of Bristol; - University of Edinburgh}, - researcherid-numbers = {Pickering, Anthony E/A-9929-2011 - Champneys, Alan R/A-2278-2013 - Briant, Linford/O-1205-2019 - Nolan, Matthew F/A-1356-2009 - }, - orcid-numbers = {Briant, Linford/0000-0003-3619-3177 - Nolan, Matthew F/0000-0003-1062-6501 - Champneys, Alan/0000-0001-7772-3686 - Pickering, Anthony/0000-0003-0345-0456}, - funding-acknowledgement = {British Heart Foundation {[}PG/06/084]; Wellcome Trust {[}088373]; - Biotechnology and Biological Sciences Research Council/Engineering; - Physical Sciences Research Council PhD Studentship}, - funding-text = {This study was supported by the British Heart Foundation (Grant - PG/06/084, PI: J. F. R. Paton) and also by The Wellcome Trust (Grant - 088373, PI: A. E. Pickering). L. J. B. Briant is supported by a - Biotechnology and Biological Sciences Research Council/Engineering and - Physical Sciences Research Council PhD Studentship. A. E. Pickering is a - Wellcome Trust Senior Clinical Research fellow.}, - number-of-cited-references = {65}, - times-cited = {10}, - usage-count-last-180-days = {0}, - usage-count-since-2013 = {5}, - journal-iso = {J. Neurophysiol.}, - doc-delivery-number = {AW1AN}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000346023000009}, - oa = {Green Submitted, Green Published}, - da = {2024-02-13} + year = {2016} } -@article{WOS:000349309400021, - author = {Ramsden, Helen L. and Suermeli, Guelsen and McDonagh, Steven G. and - Nolan, Matthew F.}, - title = {Laminar and Dorsoventral Molecular Organization of the Medial Entorhinal - Cortex Revealed by Large-scale Anatomical Analysis of Gene Expression}, - journal = {PLOS COMPUTATIONAL BIOLOGY}, - year = {2015}, - volume = {11}, - number = {1}, - month = {JAN}, - abstract = {Neural circuits in the medial entorhinal cortex (MEC) encode an animal's - position and orientation in space. Within the MEC spatial - representations, including grid and directional firing fields, have a - laminar and dorsoventral organization that corresponds to a similar - topography of neuronal connectivity and cellular properties. Yet, in - part due to the challenges of integrating anatomical data at the - resolution of cortical layers and borders, we know little about the - molecular components underlying this organization. To address this we - develop a new computational pipeline for high-throughput analysis and - comparison of in situ hybridization (ISH) images at laminar resolution. - We apply this pipeline to ISH data for over 16,000 genes in the Allen - Brain Atlas and validate our analysis with RNA sequencing of MEC tissue - from adult mice. We find that differential gene expression delineates - the borders of the MEC with neighboring brain structures and reveals its - laminar and dorsoventral organization. We propose a new molecular basis - for distinguishing the deep layers of the MEC and show that their - similarity to corresponding layers of neocortex is greater than that of - superficial layers. Our analysis identifies ion channel-, cell - adhesion-and synapse-related genes as candidates for functional - differentiation of MEC layers and for encoding of spatial information at - different scales along the dorsoventral axis of the MEC. We also reveal - laminar organization of genes related to disease pathology and suggest - that a high metabolic demand predisposes layer II to neurodegenerative - pathology. In principle, our computational pipeline can be applied to - high-throughput analysis of many forms of neuro-anatomical data. Our - results support the hypothesis that differences in gene expression - contribute to functional specialization of superficial layers of the MEC - and dorsoventral organization of the scale of spatial representations.}, - publisher = {PUBLIC LIBRARY SCIENCE}, - address = {1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA}, - type = {Article}, - language = {English}, - affiliation = {Ramsden, HL (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. - Ramsden, Helen L.; Suermeli, Guelsen; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. - Ramsden, Helen L., Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Edinburgh, Midlothian, Scotland. - McDonagh, Steven G., Univ Edinburgh, Inst Percept Act \& Behav, Sch Informat, Edinburgh, Midlothian, Scotland. - Nolan, Matthew F., inStem, Ctr Brain Dev \& Repair, Bangalore, Karnataka, India.}, - doi = {10.1371/journal.pcbi.1004032}, - article-number = {e1004032}, - issn = {1553-734X}, - eissn = {1553-7358}, - keywords-plus = {PREFERENTIAL NEURONAL LOSS; GENOME-WIDE ASSOCIATION; LAYER V NEURONS; - GRID CELLS; ELECTROPHYSIOLOGICAL CHARACTERISTICS; PARAHIPPOCAMPAL - REGION; IDENTIFIES VARIANTS; PYRAMIDAL NEURONS; MOUSE-BRAIN; ADULT}, - research-areas = {Biochemistry \& Molecular Biology; Mathematical \& Computational Biology}, - web-of-science-categories = {Biochemical Research Methods; Mathematical \& Computational Biology}, +@article{WOS:000391085500001, + abbr = {NOLAN}, + abstract = {Grid-firing fields of neurons in the entorhinal cortex are thought to + require inputs encoding running speed. Glutamatergic projections from + the medial septum may be one of the inputs that provide these speed + signals.}, + address = {75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. + Gonzalez-Sulser, Alfredo; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland.}, + affiliations = {University of Edinburgh}, + author = {Gonzalez-Sulser, Alfredo and Nolan, Matthew F.}, author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh; University of - Edinburgh; Department of Biotechnology (DBT) India; Institute for Stem - Cell Biology \& Regenerative Medicine - inStem}, + da = {2024-02-13}, + doc-delivery-number = {EG5LO}, + doi = {10.1038/nn.4460}, + eissn = {1546-1726}, + issn = {1097-6256}, + journal = {NATURE NEUROSCIENCE}, + journal-iso = {Nat. Neurosci.}, + keywords-plus = {PROJECTIONS; INTEGRATION; LOCOMOTION}, + language = {English}, + month = {JAN}, + number = {1}, + number-of-cited-references = {10}, + oa = {Green Accepted}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Gonzalez-Sulser, Alfredo/0000-0003-3494-4029}, + pages = {1-2}, + publisher = {NATURE PUBLISHING GROUP}, + research-areas = {Neurosciences \& Neurology}, researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - Surmeli, Gulsen/AAJ-1906-2020 }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - McDonagh, Steven/0000-0001-7025-5197 - SURMELI, GULSEN/0000-0002-3227-0641}, - funding-acknowledgement = {Biotechnology and Biological Sciences Research Council {[}BB/L010496/1, - BB/1022147/1]; Engineering and Physical Sciences Research Council - {[}EP/F500385/1, BB/F529254/1]; Wellcome Trust {[}098915/Z/12/Z]; - Wellcome Trust {[}098915/Z/12/Z] Funding Source: Wellcome Trust; BBSRC - {[}BB/L010496/1, BB/I022147/1] Funding Source: UKRI; Biotechnology and - Biological Sciences Research Council {[}BB/I022147/1, BB/L010496/1] - Funding Source: researchfish}, - funding-text = {This work was supported by the Biotechnology and Biological Sciences - Research Council (MFN) (BB/L010496/1 and BB/1022147/1), Engineering and - Physical Sciences Research Council (HR) (EP/F500385/1 and BB/F529254/1) - and Wellcome Trust (GS) (098915/Z/12/Z). The funders had no role in - study design, data collection and analysis, decision to publish, or - preparation of the manuscript.}, - number-of-cited-references = {103}, - times-cited = {37}, + times-cited = {2}, + title = {Grid cells' need for speed}, + type = {Editorial Material}, + unique-id = {WOS:000391085500001}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {14}, - journal-iso = {PLoS Comput. Biol.}, - doc-delivery-number = {CB0IO}, + usage-count-since-2013 = {8}, + volume = {20}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000349309400021}, - oa = {Green Published, Green Submitted, gold}, - da = {2024-02-13} + year = {2017} } -@article{WOS:000365766500020, - author = {Surmeli, Gulsen and Marcu, Daniel Cosmin and McClure, Christina and - Garden, Derek L. F. and Pastoll, Hugh and Nolan, Matthew F.}, - title = {Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep - Layers of the Medial Entorhinal Cortex}, - journal = {NEURON}, - year = {2015}, - volume = {88}, - number = {5}, - pages = {1040-1053}, - month = {DEC 2}, - abstract = {Deep layers of the medial entorhinal cortex are considered to relay - signals from the hippocampus to other brain structures, but pathways for - routing of signals to and from the deep layers are not well established. - Delineating these pathways is important for a circuit level - understanding of spatial cognition and memory. We find that neurons in - layers 5a and 5b have distinct molecular identities, defined by the - transcription factors Etv1 and Ctip2, and divergent targets, with - extensive intratelencephalic projections originating in layer 5a, but - not 5b. This segregation of outputs is mirrored by the organization of - glutamatergic input from stellate cells in layer 2 and from the - hippocampus, with both preferentially targeting layer 5b over 5a. Our - results suggest a molecular and anatomical organization of input-output - computations in deep layers of the MEC, reveal precise translaminar - microcircuitry, and identify molecularly defined pathways for spatial - signals to influence computation in deep layers.}, - publisher = {CELL PRESS}, - address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, - type = {Article}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. - Surmeli, Gulsen; Marcu, Daniel Cosmin; McClure, Christina; Garden, Derek L. F.; Pastoll, Hugh; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1016/j.neuron.2015.10.041}, - issn = {0896-6273}, - eissn = {1097-4199}, - keywords-plus = {PROJECTION NEURONS; PARAHIPPOCAMPAL REGION; GRID CELLS; RAT; - ORGANIZATION; CONNECTIONS; EXPRESSION; ORIGIN; REPRESENTATION; - SPECIFICATION}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, +@article{WOS:000393396400001, + abbr = {NOLAN}, + abstract = {Encoding of behavioral episodes as spike sequences during hippocampal + theta oscillations provides a neural substrate for computations on + events extended across time and space. However, the mechanisms + underlying the numerous and diverse experimentally observed properties + of theta sequences remain poorly understood. Here we account for theta + sequences using a novel model constrained by the septo-hippocampal + circuitry. We show that when spontaneously active interneurons integrate + spatial signals and theta frequency pacemaker inputs, they generate + phase precessing action potentials that can coordinate theta sequences + in place cell populations. We reveal novel constraints on sequence + generation, predict cellular properties and neural dynamics that + characterize sequence compression, identify circuit organization + principles for high capacity sequential representation, and show that + theta sequences can be used as substrates for association of conditioned + stimuli with recent and upcoming events. Our results suggest mechanisms + for flexible sequence compression that are suited to associative + learning across an animals lifespan.}, + address = {SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. + Chadwick, Angus; van Rossum, Mark C. W., Univ Edinburgh, Inst Adapt \& Neural Computat, Sch Informat, Edinburgh EH8 9YL, Midlothian, Scotland. + Chadwick, Angus, Univ Edinburgh, Neuroinformat Doctoral Training Ctr, Sch Informat, Edinburgh, Midlothian, Scotland. + Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh; University of + Edinburgh}, + article-number = {e20349}, + author = {Chadwick, Angus and van Rossum, Mark C. W. and Nolan, Matthew F.}, author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh}, - researcherid-numbers = {Core, Vector/CAF-4832-2022 - Surmeli, Gulsen/AAJ-1906-2020 - Garden, Derek/AAB-5908-2020 - Nolan, Matthew F/A-1356-2009 - }, - orcid-numbers = {Garden, Derek/0000-0003-3336-3791 - Nolan, Matthew F/0000-0003-1062-6501 - SURMELI, GULSEN/0000-0002-3227-0641 - Marcu, Daniel-Cosmin/0000-0002-1006-3094}, - funding-acknowledgement = {Biotechnology and Biological Sciences Research Council {[}BB/L010496/1, - BB/1022147/1]; Sir Henry Wellcome Fellowship {[}098915/Z/12/Z]; - Biotechnology and Biological Sciences Research Council {[}BB/L010496/1, - BB/I022147/1] Funding Source: researchfish; BBSRC {[}BB/I022147/1, - BB/L010496/1] Funding Source: UKRI; Wellcome Trust {[}098915/Z/12/Z] - Funding Source: Wellcome Trust}, - funding-text = {We thank Ian Duguid, Nathalie Rochefort, and Alfredo Gonzalez-Sulser for - their comments on the manuscript. We also thank Mark Robertson, Grant - Marshall, Julia Schiemann, and Kimberly Ritola-Hantman for technical - help and Thomas Jessell, Susan Morton, and Thomas Kuner for reagents. - This work was supported by the Biotechnology and Biological Sciences - Research Council (M.F.N.) (BB/L010496/1 and BB/1022147/1) and a Sir - Henry Wellcome Fellowship (GS) (098915/Z/12/Z). The funders had no role - in study design, data collection and analysis, decision to publish, or - preparation of the manuscript.}, - number-of-cited-references = {46}, - times-cited = {65}, - usage-count-last-180-days = {0}, - usage-count-since-2013 = {15}, - journal-iso = {Neuron}, - doc-delivery-number = {CX5TX}, - web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000365766500020}, - oa = {Green Published, hybrid}, - da = {2024-02-13} -} - -@article{WOS:000250952700003, - author = {Nolan, Matthew F. and Dudman, Joshua T. and Dodson, Paul D. and Santoro, - Bina}, - title = {HCN1 channels control resting and active integrative properties of - stellate cells from layer II of the entorhinal cortex}, - journal = {JOURNAL OF NEUROSCIENCE}, - year = {2007}, - volume = {27}, - number = {46}, - pages = {12440-12451}, - month = {NOV 14}, - abstract = {Whereas recent studies have elucidated principles for representation of - information within the entorhinal cortex, less is known about the - molecular basis for information processing by entorhinal neurons. The - HCN1 gene encodes ion channels that mediate hyperpolarization-activated - currents (I-h) that control synaptic integration and influence several - forms of learning and memory. We asked whether - hyperpolarization-activated, cation nonselective 1 (HCN1) channels - control processing of information by stellate cells found within layer - II of the entorhinal cortex. Axonal projections from these neurons form - a major component of the synaptic input to the dentate gyrus of the - hippocampus. To determine whether HCN1 channels control either the - resting or the active properties of stellate neurons, we performed - whole-cell recordings in horizontal brain slices prepared from adult - wild-type and HCN1 knock-out mice. We found that HCN1 channels are - required for rapid and full activation of hyperpolarization-activated - currents in stellate neurons. HCN1 channels dominate the membrane - conductance at rest, are not required for theta frequency (4-12 Hz) - membrane potential fluctuations, but suppress low-frequency (< 4 Hz) - components of spontaneous and evoked membrane potential activity. During - sustained activation of stellate cells sufficient for firing of repeated - action potentials, HCN1 channels control the pattern of spike output by - promoting recovery of the spike afterhyperpolarization. These data - suggest that HCN1 channels expressed by stellate neurons in layer II of - the entorhinal cortex are key molecular components in the processing of - inputs to the hippocampal dentate gyrus, with distinct integrative roles - during resting and active states.}, - publisher = {SOC NEUROSCIENCE}, - address = {11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA}, - type = {Article}, + da = {2024-02-13}, + doc-delivery-number = {EJ7IY}, + doi = {10.7554/eLife.20349}, + funding-acknowledgement = {Engineering and Physical Sciences Research Council {[}EP/F500385/1]; + Biotechnology and Biological Sciences Research Council {[}BB/L010496/1]; + Biotechnology and Biological Sciences Research Council {[}BB/L010496/1] + Funding Source: researchfish; BBSRC {[}BB/L010496/1] Funding Source: + UKRI}, + funding-text = {Engineering and Physical Sciences Research Council EP/F500385/1 Angus + Chadwick Mark CW van Rossum; Biotechnology and Biological Sciences + Research Council BB/L010496/1 Matthew F Nolan; The funders had no role + in study design, data collection and interpretation, or the decision to + submit the work for publication.}, + issn = {2050-084X}, + journal = {ELIFE}, + journal-iso = {eLife}, + keywords-plus = {HIPPOCAMPAL PLACE CELLS; CA1 PYRAMIDAL NEURONS; OSCILLATORY + INTERFERENCE; SEPTOTEMPORAL AXIS; VIRTUAL NAVIGATION; RAT HIPPOCAMPUS; + TEMPORAL CODE; GRID CELLS; DYNAMICS; NETWORK}, language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Neurosci Res \& Vet Biomed Sci, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland. - Univ Edinburgh, Ctr Neurosci Res \& Vet Biomed Sci, Edinburgh EH8 9XD, Midlothian, Scotland. - Columbia Univ, Ctr Neurobiol \& Behav, New York, NY 10032 USA.}, - doi = {10.1523/JNEUROSCI.2358-07.2007}, - issn = {0270-6474}, - eissn = {1529-2401}, - keywords = {parahippocampal cortex; voltage; gated ion channels; neuronal - excitability; spatial memory; I-h; epilepsy}, - keywords-plus = {SUBTHRESHOLD OSCILLATIONS; DIFFERENTIAL ELECTRORESPONSIVENESS; SPATIAL - REPRESENTATION; DENDRITIC INTEGRATION; PYRAMIDAL NEURONS; IONIC - MECHANISMS; CATION CURRENTS; PERFORANT PATH; H-CHANNEL; RAT}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; Columbia University}, + month = {DEC 8}, + number-of-cited-references = {79}, + oa = {gold, Green Submitted, Green Published, Green Accepted}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Chadwick, Angus/0000-0003-2664-0746 + van Rossum, Mark CW/0000-0001-6525-6814}, + publisher = {ELIFE SCIENCES PUBLICATIONS LTD}, + research-areas = {Life Sciences \& Biomedicine - Other Topics}, researcherid-numbers = {Nolan, Matthew F/A-1356-2009 }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Dodson, Paul/0000-0003-0858-6088 - Santoro, Bina/0000-0002-4277-1992}, - funding-acknowledgement = {Medical Research Council {[}G0501216] Funding Source: Medline; NINDS NIH - HHS {[}R56 NS036658, NS36658, R01 NS036658] Funding Source: Medline; - Medical Research Council {[}G0501216] Funding Source: researchfish; MRC - {[}G0501216] Funding Source: UKRI}, - number-of-cited-references = {62}, - times-cited = {146}, + times-cited = {10}, + title = {Flexible theta sequence compression mediated via phase precessing + interneurons}, + type = {Article}, + unique-id = {WOS:000393396400001}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {16}, - journal-iso = {J. Neurosci.}, - doc-delivery-number = {231NA}, + usage-count-since-2013 = {6}, + volume = {5}, + web-of-science-categories = {Biology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000250952700003}, - oa = {Green Published, hybrid}, - da = {2024-02-13} + year = {2016} } -@article{WOS:000850307700001, - author = {Tian, Tian and Yuan, Yifang and Mitra, Srinjoy and Gyongy, Istvan and - Nolan, Matthew F.}, - title = {Single Photon Kilohertz Frame Rate Imaging of Neural Activity}, - journal = {ADVANCED SCIENCE}, - year = {2022}, - volume = {9}, - number = {31}, - month = {NOV}, - abstract = {Establishing the biological basis of cognition and its disorders will - require high precision spatiotemporal measurements of neural activity. - Recently developed genetically encoded voltage indicators (GEVIs) report - both spiking and subthreshold activity of identified neurons. However, - maximally capitalizing on the potential of GEVIs will require imaging at - millisecond time scales, which remains challenging with standard camera - systems. Here, application of single photon avalanche diode (SPAD) - sensors is reported to image neural activity at kilohertz frame rates. - SPADs are electronic devices that when activated by a single photon - cause an avalanche of electrons and a large electric current. An array - of SPAD sensors is used to image individual neurons expressing the GEVI - Voltron-JF525-HTL. It is shown that subthreshold and spiking activity - can be resolved with shot noise limited signals at frame rates of up to - 10 kHz. SPAD imaging is able to reveal millisecond scale synchronization - of neural activity in an ex vivo seizure model. SPAD sensors may have - widespread applications for investigation of millisecond timescale - neural dynamics.}, - publisher = {WILEY}, +@article{WOS:000394581400027, + abbr = {NOLAN}, + abstract = {The inferior olive plays a critical role in motor coordination and + learning by integrating diverse afferent signals to generate climbing + fibre inputs to the cerebellar cortex. While it is well established that + climbing fibre signals are important for motor coordination, the + mechanisms by which neurones in the inferior olive integrate synaptic + inputs and the roles of particular ion channels are unclear. Here, we + test the hypothesis that neurones in the inferior olive actively + integrate glutamatergic synaptic inputs. We demonstrate that + optogenetically activated long-range synaptic inputs to the inferior + olive, including projections from the motor cortex, generate rapid + excitatory potentials followed by slower inhibitory potentials. Synaptic + projections from the motor cortex preferentially target the principal + olivary nucleus. We show that inhibitory and excitatory components of + the bidirectional synaptic potentials are dependent upon AMPA (GluA) + receptors, are GABA(A) independent, and originate from the same + presynaptic axons. Consistent with models that predict active + integration of synaptic inputs by inferior olive neurones, we find that + the inhibitory component is reduced by blocking large conductance + calcium-activated potassium channels with iberiotoxin, and is abolished + by blocking small conductance calcium-activated potassium channels with + apamin. Summation of excitatory components of synaptic responses to + inputs at intervals 20ms is increased by apamin, suggesting a role for + the inhibitory component of glutamatergic responses in temporal + integration. Our results indicate that neurones in the inferior olive + implement novel rules for synaptic integration and suggest new + principles for the contribution of inferior olive neurones to + coordinated motor behaviours.}, address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, - type = {Article}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. - Gyongy, I (Corresponding Author), Univ Edinburgh, Sch Engn, Inst Integrated Micro \& Nano Syst, Edinburgh EH9 3JL, Midlothian, Scotland. - Nolan, MF (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh EH8 9XD, Midlothian, Scotland. - Tian, Tian; Yuan, Yifang; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. - Mitra, Srinjoy; Gyongy, Istvan, Univ Edinburgh, Sch Engn, Inst Integrated Micro \& Nano Syst, Edinburgh EH9 3JL, Midlothian, Scotland. - Nolan, Matthew F., Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1002/advs.202203018}, - earlyaccessdate = {SEP 2022}, - article-number = {2203018}, - eissn = {2198-3844}, - keywords = {genetically encoded voltage indicators (GEVIs); kilohertz frame rate; - neural activity; shot noise; single photon avalanche diodes (SPADs); - temporal binning; voltage imaging}, - research-areas = {Chemistry; Science \& Technology - Other Topics; Materials Science}, - web-of-science-categories = {Chemistry, Multidisciplinary; Nanoscience \& Nanotechnology; Materials - Science, Multidisciplinary}, - author-email = {igyongy2@exseed.ed.ac.uk - mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh; University of - Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - Gyongy, Istvan/GLR-3372-2022 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Gyongy, Istvan/0000-0003-3931-7972}, - funding-acknowledgement = {Wellcome Trust {[}IS3-R2.36, 200855/Z/16/Z]; BBSRC EastBio doctoral - training programme; EPSRC {[}EP/S001638/1]; Wellcome Trust - {[}200855/Z/16/Z] Funding Source: Wellcome Trust}, - funding-text = {The authors thank Robert Henderson and Ian Duguid for helpful - discussions and support. The project was supported by funding from the - Wellcome Trust (ISSF3 award IS3-R2.36 to IG and MFN, and Investigator - Award 200855/Z/16/Z to MFN), the BBSRC EastBio doctoral training - programme, and EPSRC (EP/S001638/1). For the purpose of open access, the - author has applied a CC by public copyright license to any Author - Accepted Manuscript version arising from this submission.}, - number-of-cited-references = {27}, - times-cited = {3}, - usage-count-last-180-days = {2}, - usage-count-since-2013 = {18}, - journal-iso = {Adv. Sci.}, - doc-delivery-number = {5W8UC}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. + Garden, Derek L. F.; Rinaldi, Arianna; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh}, + author = {Garden, Derek L. F. and Rinaldi, Arianna and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {EL4HD}, + doi = {10.1113/JP273424}, + eissn = {1469-7793}, + funding-acknowledgement = {Medical Research Council {[}G0501216]; Wellcome Trust {[}093295/Z/10/Z]; + BBSRC {[}Bb/H020284/1]; BBSRC {[}BB/H020284/1] Funding Source: UKRI; MRC + {[}G0501216] Funding Source: UKRI; Biotechnology and Biological Sciences + Research Council {[}BB/H020284/1] Funding Source: researchfish; Medical + Research Council {[}G0501216] Funding Source: researchfish; Wellcome + Trust {[}093295/Z/10/Z] Funding Source: Wellcome Trust}, + funding-text = {This work was supported by the Medical Research Council (G0501216), the + Wellcome Trust (093295/Z/10/Z) and the BBSRC (Bb/H020284/1).}, + issn = {0022-3751}, + journal = {JOURNAL OF PHYSIOLOGY-LONDON}, + journal-iso = {J. Physiol.-London}, + keywords = {inferior olive; ion channel; synaptic integration}, + keywords-plus = {ELECTROPHYSIOLOGICAL PROPERTIES; MOTOR-CORTEX; SK CHANNELS; IN-VITRO; + NEURONS; OSCILLATIONS; MODULATION; CAT; ACTIVATION; PROJECTION}, + language = {English}, + month = {FEB}, + number = {4}, + number-of-cited-references = {43}, + oa = {hybrid, Green Published}, + orcid-numbers = {Rinaldi, Arianna/0000-0002-5167-7420 + RINALDI, ARIANNA/0000-0002-5167-7420 + Nolan, Matthew F/0000-0003-1062-6501 + Garden, Derek/0000-0003-3336-3791}, + pages = {1239-1251}, + publisher = {WILEY}, + research-areas = {Neurosciences \& Neurology; Physiology}, + researcherid-numbers = {Rinaldi, Arianna/F-4713-2018 + RINALDI, ARIANNA/AGG-5346-2022 + Nolan, Matthew F/A-1356-2009 + Garden, Derek/AAB-5908-2020}, + times-cited = {9}, + title = {Active integration of glutamatergic input to the inferior olive + generates bidirectional postsynaptic potentials}, + type = {Article}, + unique-id = {WOS:000394581400027}, + usage-count-last-180-days = {0}, + usage-count-since-2013 = {3}, + volume = {595}, + web-of-science-categories = {Neurosciences; Physiology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000850307700001}, - oa = {Green Published, Green Submitted, gold}, - da = {2024-02-13} + year = {2017} } -@article{WOS:000348683800002, - author = {Chadwick, Angus and van Rossum, Mark C. W. and Nolan, Matthew F.}, - title = {Independent Theta Phase Coding Accounts for CA1 Population Sequences and - Enables Flexible Remapping}, - journal = {ELIFE}, - year = {2015}, - volume = {4}, - month = {FEB 2}, - abstract = {Hippocampal place cells encode an animal's past, current and future - location through sequences of action potentials generated within each - cycle of the network theta rhythm. These sequential representations have - been suggested to result from temporally coordinated synaptic - interactions within and between cell assemblies. Instead, we find - through simulations and analysis of experimental data that rate and - phase coding in independent neurons is sufficient to explain the - organization of CA1 population activity during theta states. We show - that CA1 population activity can be described as an evolving traveling - wave that exhibits phase coding, rate coding, spike sequences and that - generates an emergent population theta rhythm. We identify measures of - global remapping and intracellular theta dynamics as critical for - distinguishing mechanisms for pacemaking and coordination of sequential - population activity. Our analysis suggests that, unlike synaptically - coupled assemblies, independent neurons flexibly generate sequential - population activity within the duration of a single theta cycle.}, - publisher = {ELIFE SCIENCES PUBLICATIONS LTD}, - address = {SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND}, - type = {Article}, +@article{WOS:000413916800007, + abbr = {NOLAN}, + abstract = {Synaptic integrative mechanisms have profound effects on electrical + signaling in the brain that, although largely hidden from recording + methods that observe the spiking activity of neurons, may be critical + for the encoding, storage and retrieval of information. Here we review + roles for synaptic integrative mechanisms in the selection, generation + and plasticity of place and grid fields, and in related temporal codes + for the representation of space. We outline outstanding questions and + challenges in the testing of hypothesized models for spatial computation + and memory.}, + address = {HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY}, + affiliation = {Schmidt-Hieber, C (Corresponding Author), Inst Pasteur, Paris, France. + Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland. + Schmidt-Hieber, Christoph, Inst Pasteur, Paris, France. + Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland.}, + affiliations = {Le Reseau International des Instituts Pasteur (RIIP); Universite Paris + Cite; Institut Pasteur Paris; University of Edinburgh}, + author = {Schmidt-Hieber, Christoph and Nolan, Matthew F.}, + author-email = {christoph.schmidt-hieber@pasteur.fr + mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {FL0QV}, + doi = {10.1038/nn.4652}, + eissn = {1546-1726}, + funding-acknowledgement = {BBSRC {[}BB/M025454/1, BB/L010496/1]; Human Frontiers Science Program + {[}RGP0062/2014]; Wellcome Trust {[}200855/Z/16/Z]; Simons Initiative + for the Developing Brain; ERC {[}StG 678790 NEWRON]; Biotechnology and + Biological Sciences Research Council {[}BB/L010496/1, BB/M025454/1] + Funding Source: researchfish; BBSRC {[}BB/L010496/1, BB/M025454/1] + Funding Source: UKRI; Wellcome Trust {[}200855/Z/16/Z] Funding Source: + Wellcome Trust}, + funding-text = {We thank N. Rochefort and G. Surmeli for comments on the manuscript, A. + Lee for sharing data before publication (ref. 26), and G. Buzsaki and E. + Stark for sharing material for the generation of figures. This work was + funded in part by the BBSRC (grants BB/M025454/1 and BB/L010496/1 to + M.F.N.), the Human Frontiers Science Program (grant RGP0062/2014 to + M.F.N.), the Wellcome Trust (grant 200855/Z/16/Z to M.F.N.), the Simons + Initiative for the Developing Brain (M.F.N.) and the ERC (grant StG + 678790 NEWRON to C.S.-H.).}, + issn = {1097-6256}, + journal = {NATURE NEUROSCIENCE}, + journal-iso = {Nat. Neurosci.}, + keywords-plus = {HIPPOCAMPAL PYRAMIDAL CELLS; MEDIAL ENTORHINAL CORTEX; THETA PHASE + PRECESSION; LONG-TERM POTENTIATION; PLACE CELLS; DENDRITIC INTEGRATION; + HCN1 CHANNELS; DISTAL DENDRITES; STELLATE CELLS; GRID CELLS}, language = {English}, - affiliation = {Chadwick, A (Corresponding Author), Univ Edinburgh, Sch Informat, Inst Adapt \& Neural Computat, Edinburgh EH8 9AB, Midlothian, Scotland. - Chadwick, Angus; van Rossum, Mark C. W., Univ Edinburgh, Sch Informat, Inst Adapt \& Neural Computat, Edinburgh EH8 9AB, Midlothian, Scotland. - Chadwick, Angus, Univ Edinburgh, Sch Informat, Neuroinformat Doctoral Training Ctr, Edinburgh EH8 9AB, Midlothian, Scotland. - Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.7554/eLife.03542}, - article-number = {e03542}, - issn = {2050-084X}, - keywords-plus = {HIPPOCAMPAL PLACE CELLS; NETWORK DYNAMICS; PYRAMIDAL CELLS; RUNNING - SPEED; PRECESSION; ASSEMBLIES; CODE; OSCILLATIONS; INHIBITION; FREQUENCY}, - research-areas = {Life Sciences \& Biomedicine - Other Topics}, - web-of-science-categories = {Biology}, - affiliations = {University of Edinburgh; University of Edinburgh; University of - Edinburgh}, - researcherid-numbers = {van Rossum, Mark/AAF-6620-2019 - Nolan, Matthew F/A-1356-2009 + month = {NOV}, + number = {11}, + number-of-cited-references = {149}, + oa = {Green Accepted}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Schmidt-Hieber, Christoph/0000-0002-5328-9704}, + pages = {1483-1492}, + publisher = {NATURE PORTFOLIO}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 }, - orcid-numbers = {van Rossum, Mark/0000-0001-6525-6814 - Nolan, Matthew F/0000-0003-1062-6501 - Chadwick, Angus/0000-0003-2664-0746}, - funding-acknowledgement = {EPSRC; BBSRC; MRC}, - funding-text = {This work was supported by the EPSRC, BBSRC and MRC. We thank Gyuri - Buzsaki, Kamran Diba and Iris Oren for helpful comments on the - manuscript. We are grateful for the provision of experimental data, made - freely available at crcns.org (Mizuseki et al., 2014).}, - number-of-cited-references = {75}, - times-cited = {31}, + times-cited = {23}, + title = {Synaptic integrative mechanisms for spatial cognition}, + type = {Review}, + unique-id = {WOS:000413916800007}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {2}, - journal-iso = {eLife}, - doc-delivery-number = {CA1PH}, + usage-count-since-2013 = {44}, + volume = {20}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000348683800002}, - oa = {Green Published, Green Accepted, gold, Green Submitted}, - da = {2024-02-13} + year = {2017} } -@article{WOS:000710927500041, - author = {Hristova, Katerina and Martinez-Gonzalez, Cristina and Watson, Thomas C. - and Codadu, Neela K. and Hashemi, Kevan and Kind, Peter C. and Nolan, - Matthew F. and Gonzalez-Sulser, Alfredo}, - title = {Medial septal GABAergic neurons reduce seizure duration upon optogenetic - closed-loop stimulation}, - journal = {BRAIN}, - year = {2021}, - volume = {144}, +@article{WOS:000423898500019, + abbr = {NOLAN}, + abstract = {Spatial learning requires estimates of location that may be obtained by + path integration or from positional cues. Grid and other spatial firing + patterns of neurons in the superficial medial entorhinal cortex (MEC) + suggest roles in behavioral estimation of location. However, + distinguishing the contributions of path integration and cue-based + signals to spatial behaviors is challenging, and the roles of identified + MEC neurons are unclear. We use virtual reality to dissociate linear + path integration from other strategies for behavioral estimation of + location. We find that mice learn to path integrate using motor-related + self-motion signals, with accuracy that decreases steeply as a function + of distance. We show that inactivation of stellate cells in superficial + MEC impairs spatial learning in virtual reality and in a real world + object location recognition task. Our results quantify contributions of + path integration to behavior and corroborate key predictions of models + in which stellate cells contribute to location estimation.}, + address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. + Tennant, Sarah A.; Fischer, Lukas; Garden, Derek L. F.; Gerlei, Klara Zsofia; Martinez-Gonzalez, Cristina; McClure, Christina; Wood, Emma R.; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh}, + author = {Tennant, Sarah A. and Fischer, Lukas and Garden, Derek L. F. and Gerlei, + Klara Zsofia and Martinez-Gonzalez, Cristina and McClure, Christina and + Wood, Emma R. and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {FU5MV}, + doi = {10.1016/j.celrep.2018.01.005}, + funding-acknowledgement = {BBSRC {[}BB/L010496/1, BB/M010996/1]; Human Frontiers Science Program + {[}RGP0062/2014]; Wellcome Trust {[}200855/Z/16/Z, WT093295MA]; Wellcome + Trust {[}200855/Z/16/Z] Funding Source: Wellcome Trust; BBSRC + {[}BB/L010496/1, BB/H020284/1] Funding Source: UKRI; Biotechnology and + Biological Sciences Research Council {[}BB/H020284/1, 1312826, 1068019, + BB/L010496/1] Funding Source: researchfish; Wellcome Trust + {[}200855/Z/16/Z] Funding Source: researchfish}, + funding-text = {We thank Ian Duguid for advice in establishing head fixation and + treadmill technologies, Gulsen Surmeli for assistance in targeting of + L2SCs, and Jessica Menzies and Michelle Haglund for collecting the + object recognition and object location data. This work was supported by + the BBSRC (BB/L010496/1 and a BBSRC Eastbio studentship {[}grant + BB/M010996/1]), the Human Frontiers Science Program (RGP0062/2014), and + the Wellcome Trust (200855/Z/16/Z and WT093295MA). The funders had no + role in study design, data collection and analysis, decision to publish, + or preparation of the manuscript.}, + issn = {2211-1247}, + journal = {CELL REPORTS}, + journal-iso = {Cell Reports}, + keywords-plus = {GRID CELLS; PATH-INTEGRATION; OCEAN CELLS; INPUT; PLACE; MODEL; + REPRESENTATION; CONTRIBUTE; NAVIGATION; CIRCUITRY}, + language = {English}, + month = {JAN 30}, number = {5}, - pages = {1576-1589}, - month = {MAY}, - abstract = {Seizures can emerge from multiple or large foci in temporal lobe - epilepsy, complicating focally targeted strategies such as surgical - resection or the modulation of the activity of specific hippocampal - neuronal populations through genetic or optogenetic techniques. Here, we - evaluate a strategy in which optogenetic activation of medial septal - GABAergic neurons, which provide extensive projections throughout the - hippocampus, is used to control seizures. We utilized the chronic - intrahippocampal kainate mouse model of temporal lobe epilepsy, which - results in spontaneous seizures and as is often the case in human - patients, presents with hippocampal sclerosis. Medial septal GABAergic - neuron populations were immunohistochemically labelled and were not - reduced in epileptic conditions. Genetic labelling with mRuby of medial - septal GABAergic neuron synaptic puncta and imaging across the rostral - to caudal extent of the hippocampus, also indicated an unchanged number - of putative synapses in epilepsy. Furthermore, optogenetic stimulation - of medial septal GABAergic neurons consistently modulated oscillations - across multiple hippocampal locations in control and epileptic - conditions. Finally, wireless optogenetic stimulation of medial septal - GABAergic neurons, upon electrographic detection of spontaneous - hippocampal seizures, resulted in reduced seizure durations. We propose - medial septal GABAergic neurons as a novel target for optogenetic - control of seizures in temporal lobe epilepsy.}, - publisher = {OXFORD UNIV PRESS}, - address = {GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND}, - type = {Article}, - language = {English}, - affiliation = {Gonzalez-Sulser, A (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Patrick Wild Ctr, Simons Initiat Developing Brain, Edinburgh, Midlothian, Scotland. - Hristova, Katerina; Martinez-Gonzalez, Cristina; Watson, Thomas C.; Codadu, Neela K.; Kind, Peter C.; Nolan, Matthew F.; Gonzalez-Sulser, Alfredo, Univ Edinburgh, Ctr Discovery Brain Sci, Patrick Wild Ctr, Simons Initiat Developing Brain, Edinburgh, Midlothian, Scotland. - Hristova, Katerina; Martinez-Gonzalez, Cristina; Watson, Thomas C.; Codadu, Neela K.; Kind, Peter C.; Nolan, Matthew F.; Gonzalez-Sulser, Alfredo, Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Midlothian, Scotland. - Hristova, Katerina; Martinez-Gonzalez, Cristina; Watson, Thomas C.; Codadu, Neela K.; Kind, Peter C.; Nolan, Matthew F.; Gonzalez-Sulser, Alfredo, Univ Edinburgh, Patrick Wild Ctr, Edinburgh, Midlothian, Scotland. - Hashemi, Kevan, Open Source Instruments, Watertown, MA USA.}, - doi = {10.1093/brain/awab042}, - earlyaccessdate = {MAR 2021}, - issn = {0006-8950}, - eissn = {1460-2156}, - keywords = {medial septum GABAergic neurons; temporal lobe epilepsy; network - stimulation; optogenetics; wireless closed-loop intervention}, - keywords-plus = {TEMPORAL-LOBE EPILEPSY; DENTATE GYRUS; HIPPOCAMPAL SCLEROSIS; THETA - OSCILLATIONS; MOUSE MODEL; INTERNEURONS; BRAIN; PROJECTIONS; PATHWAYS; - CELLS}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Clinical Neurology; Neurosciences}, - author-email = {agonzal2@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh; University of - Edinburgh}, - researcherid-numbers = {Core, Vector/CAF-4832-2022 - Nolan, Matthew F/A-1356-2009 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Kind, Peter/0000-0002-4256-9639 - Martinez-Gonzalez, Cristina/0000-0001-9969-1160 - Gonzalez-Sulser, Alfredo/0000-0003-3494-4029 - Codadu, Neela Krushna/0000-0002-5819-0340}, - funding-acknowledgement = {Epilepsy Research UK {[}F1603, P1602]; Simons Initiative for the - Developing Brain; Medical Research Council {[}MR/P006213/1]; Wellcome - Trust {[}200855/Z/16/Z]; MRC {[}MR/P006213/1] Funding Source: UKRI; - Wellcome Trust {[}200855/Z/16/Z] Funding Source: Wellcome Trust}, - funding-text = {This work was supported by Epilepsy Research UK F1603 (A.G.S.) and P1602 - (N.K.C.), the Simons Initiative for the Developing Brain (A.G.S., K.H., - C.M.G., T.C.W., N.K.C, P.C.K., M.F.N.), the Medical Research Council - MR/P006213/1 (P.C.K.) and the Wellcome Trust 200855/Z/16/Z (M.F.N.)}, - number-of-cited-references = {82}, - times-cited = {21}, - usage-count-last-180-days = {7}, - usage-count-since-2013 = {23}, - journal-iso = {Brain}, - doc-delivery-number = {WM2NM}, - web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000710927500041}, - oa = {Green Published, hybrid, Green Accepted}, - da = {2024-02-13} -} - -@article{WOS:000346191500020, - author = {Gonzalez-Sulser, Alfredo and Parthier, Daniel and Candela, Antonio and - McClure, Christina and Pastoll, Hugh and Garden, Derek and Suermeli, - Guelsen and Nolan, Matthew F.}, - title = {GABAergic Projections from the Medial Septum Selectively Inhibit - Interneurons in the Medial Entorhinal Cortex}, - journal = {JOURNAL OF NEUROSCIENCE}, - year = {2014}, - volume = {34}, - number = {50}, - pages = {16739-16743}, - month = {DEC 10}, - abstract = {The medial septum (MS) is required for theta rhythmic oscillations and - grid cell firing in the medial entorhinal cortex (MEC). While GABAergic, - glutamatergic, and cholinergic neurons project from the MS to the MEC, - their synaptic targets are unknown. To investigate whether MSneurons - innervate specific layers and cell types in the MEC, we expressed - channelrhodopsin-2 in mouse MSneurons and used patch-clamp recording in - brain slices to determine the response to light activation of identified - cells in the MEC. Following activation of MS axons, we observed fast - monosynaptic GABAergic IPSPs in the majority (>60\%) of fast-spiking - (FS) and low-threshold-spiking (LTS) interneurons in all layers of the - MEC, but in only 1.5\% of nonstellate principal cells (NSPCs) and in no - stellate cells. We also observed fast glutamatergic responses to MS - activation in a minority (<5\%) of NSPCs, FS, and LTS interneurons. - During stimulation of MS inputs at theta frequency (10 Hz), the - amplitude of GABAergic IPSPs was maintained, and spike output from LTS - and FS interneurons was entrained at low (25-60 Hz) and high (60-180 Hz) - gamma frequencies, respectively. By demonstrating cell type-specific - targeting of the GABAergic projection from the MS to the MEC, our - results support the idea that the MS controls theta frequency activity - in the MEC through coordination of inhibitory circuits.}, - publisher = {SOC NEUROSCIENCE}, - address = {11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA}, - type = {Article}, - language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Ctr Integrat Physiol, Hugh Robson Bldg,15 George Sq, Edinburgh EH8 9XD, Midlothian, Scotland. - Gonzalez-Sulser, Alfredo; Parthier, Daniel; Candela, Antonio; McClure, Christina; Pastoll, Hugh; Garden, Derek; Suermeli, Guelsen; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1523/JNEUROSCI.1612-14.2014}, - issn = {0270-6474}, - keywords = {gamma; interneuron; lamina organization; medial entorhinal cortex; - medial septum; theta}, - keywords-plus = {GAMMA OSCILLATIONS; THETA-RHYTHM; LAYER-II; SPATIAL PERIODICITY; FIRING - FIELDS; GRID CELLS; NEURONS; RAT; HIPPOCAMPUS; AREA}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh}, + number-of-cited-references = {62}, + oa = {Green Published, gold}, + orcid-numbers = {Garden, Derek/0000-0003-3336-3791 + Nolan, Matthew F/0000-0003-1062-6501 + Martinez-Gonzalez, Cristina/0000-0001-9969-1160}, + pages = {1313-1324}, + publisher = {CELL PRESS}, + research-areas = {Cell Biology}, researcherid-numbers = {Garden, Derek/AAB-5908-2020 - Surmeli, Gulsen/AAJ-1906-2020 - Core, Vector/CAF-4832-2022 Nolan, Matthew F/A-1356-2009 }, - orcid-numbers = {Garden, Derek/0000-0003-3336-3791 - Nolan, Matthew F/0000-0003-1062-6501 - Parthier, Daniel/0000-0001-8775-024X - SURMELI, GULSEN/0000-0002-3227-0641 - Gonzalez-Sulser, Alfredo/0000-0003-3494-4029}, - funding-acknowledgement = {Biotechnology and Biological Sciences Research Council (BBSRC) - {[}BB/L010496/1, BB/H020284/1]; Marie-Curie International Incoming - Post-Doctoral Fellowship {[}629586]; Sir Henry Wellcome Postdoctoral - Fellowship {[}098915/Z/12/z]; BBSRC {[}BB/L010496/1, BB/H020284/1] - Funding Source: UKRI; Biotechnology and Biological Sciences Research - Council {[}BB/H020284/1, BB/L010496/1] Funding Source: researchfish; - Wellcome Trust {[}098915/Z/12/Z] Funding Source: Wellcome Trust}, - funding-text = {This work was supported by the Biotechnology and Biological Sciences - Research Council (BBSRC Grants BB/L010496/1 and BB/H020284/1 to M.F.N.), - a Marie-Curie International Incoming Post-Doctoral Fellowship (629586 to - A.G.-S.), and a Sir Henry Wellcome Postdoctoral Fellowship - (098915/Z/12/z to G.S.). We thank the IMPACT facility at the University - of Edinburgh for imaging resources.}, - number-of-cited-references = {26}, - times-cited = {59}, - usage-count-last-180-days = {0}, - usage-count-since-2013 = {12}, - journal-iso = {J. Neurosci.}, - doc-delivery-number = {AW3MS}, - web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000346191500020}, - oa = {Green Published, hybrid}, - da = {2024-02-13} -} - -@article{WOS:000934319900001, - author = {Vandrey, Brianna and Armstrong, Jack and Brown, Christina M. and Garden, - Derek L. F. and Nolan, Matthew F.}, - title = {Fan cells in lateral entorhinal cortex directly influence medial - entorhinal cortex through synaptic connections in layer 1}, - journal = {ELIFE}, - year = {2022}, - volume = {11}, - month = {DEC 23}, - abstract = {Standard models for spatial and episodic memory suggest that the lateral - entorhinal cortex (LEC) and medial entorhinal cortex (MEC) send parallel - independent inputs to the hippocampus, each carrying different types of - information. Here, we evaluate the possibility that information is - integrated between divisions of the entorhinal cortex prior to reaching - the hippocampus. We demonstrate that, in mice, fan cells in layer 2 (L2) - of LEC that receive neocortical inputs, and that project to the - hippocampal dentate gyrus, also send axon collaterals to layer 1 (L1) of - the MEC. Activation of inputs from fan cells evokes monosynaptic - glutamatergic excitation of stellate and pyramidal cells in L2 of the - MEC, typically followed by inhibition that contains fast and slow - components mediated by GABA(A) and GABA(B) receptors, respectively. - Inputs from fan cells also directly activate interneurons in L1 and L2 - of MEC, with synaptic connections from L1 interneurons accounting for - slow feedforward inhibition of L2 principal cell populations. The - relative strength of excitation and inhibition following fan cell - activation differs substantially between neurons and is largely - independent of anatomical location. Our results demonstrate that the - LEC, in addition to directly influencing the hippocampus, can activate - or inhibit major hippocampal inputs arising from the MEC. Thus, local - circuits in the superficial MEC may combine spatial information with - sensory and higher order signals from the LEC, providing a substrate for - integration of `what' and `where' components of episodic memories.}, - publisher = {eLIFE SCIENCES PUBL LTD}, - address = {SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND}, + times-cited = {40}, + title = {Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial + Learning}, type = {Article}, - language = {English}, - affiliation = {Vandrey, B; Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Scotland. - Nolan, MF (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Scotland. - Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Stat, Edinburgh, Scotland. - Vandrey, Brianna; Armstrong, Jack; Brown, Christina M.; Garden, Derek L. F.; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Scotland. - Nolan, Matthew F., Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Scotland. - Nolan, Matthew F., Univ Edinburgh, Ctr Stat, Edinburgh, Scotland.}, - doi = {10.7554/eLife.83008}, - article-number = {e83008}, - issn = {2050-084X}, - keywords = {memory; neural circuit; hippocampal formation; optogenetics; Mouse}, - keywords-plus = {TOPOGRAPHIC ORGANIZATION; HIPPOCAMPAL-FORMATION; STELLATE CELLS; - PARAHIPPOCAMPAL REGION; PERIRHINAL CORTEX; RETROHIPPOCAMPAL REGION; - EFFERENT CONNECTIONS; POSTRHINAL CORTICES; ASSOCIATION CORTEX; PYRAMIDAL - NEURONS}, - research-areas = {Life Sciences \& Biomedicine - Other Topics}, - web-of-science-categories = {Biology}, - author-email = {brianna.vandrey@ed.ac.uk - mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh; University of - Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Garden, Derek/0000-0003-3336-3791}, - funding-acknowledgement = {Wellcome Trust {[}200855/Z/16/Z]; BBSRC {[}BB/V010107/1]; Wellcome Trust - {[}200855/Z/16/Z] Funding Source: Wellcome Trust}, - funding-text = {The funders had no role in study design, data collection and - interpretation, or the decision to submit the work for publication. For - the purpose of Open Access, the authors have applied a CC BY public - copyright license to any Author Accepted Manuscript version arising from - this submission.}, - number-of-cited-references = {103}, - times-cited = {2}, - usage-count-last-180-days = {0}, - usage-count-since-2013 = {5}, - journal-iso = {eLife}, - doc-delivery-number = {9A8SC}, + unique-id = {WOS:000423898500019}, + usage-count-last-180-days = {2}, + usage-count-since-2013 = {14}, + volume = {22}, + web-of-science-categories = {Cell Biology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000934319900001}, - oa = {Green Submitted, Green Published, gold}, - da = {2024-02-13} + year = {2018} } @article{WOS:000424981600009, - author = {Garden, Derek L. F. and Oostland, Marlies and Jelitai, Marta and - Rinaldi, Arianna and Duguid, Ian and Nolan, Matthew F.}, - title = {Inferior Olive HCN1 Channels Coordinate Synaptic Integration and Complex - Spike Timing}, - journal = {CELL REPORTS}, - year = {2018}, - volume = {22}, - number = {7}, - pages = {1722-1733}, - month = {FEB 13}, + abbr = {NOLAN}, abstract = {Cerebellar climbing-fiber-mediated complex spikes originate from neurons in the inferior olive (IO), are critical for motor coordination, and are central to theories of cerebellar learning. Hyperpolarization-activated @@ -2490,34 +2053,18 @@ @article{WOS:000424981600009 channels enable the IO to implement network-wide rules for synaptic integration that modulate the timing of cerebellar climbing fiber signals.}, - publisher = {CELL PRESS}, address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, - type = {Article}, - language = {English}, affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. Nolan, MF (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh EH8 9XD, Midlothian, Scotland. Garden, Derek L. F.; Oostland, Marlies; Jelitai, Marta; Rinaldi, Arianna; Duguid, Ian; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. Duguid, Ian; Nolan, Matthew F., Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1016/j.celrep.2018.01.069}, - issn = {2211-1247}, - keywords-plus = {CEREBELLAR PURKINJE-CELLS; NEURONS IN-VITRO; GAP-JUNCTIONS; DENDRITIC - INTEGRATION; GLUTAMATERGIC INPUT; IONIC CONDUCTANCES; OSCILLATIONS; - MODULATION; NETWORK; ORGANIZATION}, - research-areas = {Cell Biology}, - web-of-science-categories = {Cell Biology}, - author-email = {mattnolan@ed.ac.uk}, affiliations = {University of Edinburgh; University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - Rinaldi, Arianna/F-4713-2018 - Garden, Derek/AAB-5908-2020 - RINALDI, ARIANNA/AGG-5346-2022 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Rinaldi, Arianna/0000-0002-5167-7420 - Garden, Derek/0000-0003-3336-3791 - RINALDI, ARIANNA/0000-0002-5167-7420 - Oostland, Marlies/0000-0001-9474-4040 - Duguid, Ian/0000-0001-6966-2641}, + author = {Garden, Derek L. F. and Oostland, Marlies and Jelitai, Marta and + Rinaldi, Arianna and Duguid, Ian and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {FW0JV}, + doi = {10.1016/j.celrep.2018.01.069}, funding-acknowledgement = {Medical Research Council {[}G0501216]; Wellcome Trust {[}093295/Z/10/Z, 086602/Z/08/Z]; BBSRC {[}Bb/H020284/1]; Wellcome Trust {[}086602/Z/08/Z, 093295/Z/10/Z] Funding Source: Wellcome Trust; BBSRC {[}BB/H020284/1] @@ -2530,351 +2077,728 @@ @ed.ac.uk (Bb/H020284/1). We thank Paolo Puggioni for help with motion analysis and the IMPACT facility at the University of Edinburgh for imaging resources.}, + issn = {2211-1247}, + journal = {CELL REPORTS}, + journal-iso = {Cell Reports}, + keywords-plus = {CEREBELLAR PURKINJE-CELLS; NEURONS IN-VITRO; GAP-JUNCTIONS; DENDRITIC + INTEGRATION; GLUTAMATERGIC INPUT; IONIC CONDUCTANCES; OSCILLATIONS; + MODULATION; NETWORK; ORGANIZATION}, + language = {English}, + month = {FEB 13}, + number = {7}, number-of-cited-references = {43}, + oa = {Green Published, gold}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Rinaldi, Arianna/0000-0002-5167-7420 + Garden, Derek/0000-0003-3336-3791 + RINALDI, ARIANNA/0000-0002-5167-7420 + Oostland, Marlies/0000-0001-9474-4040 + Duguid, Ian/0000-0001-6966-2641}, + pages = {1722-1733}, + publisher = {CELL PRESS}, + research-areas = {Cell Biology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + Rinaldi, Arianna/F-4713-2018 + Garden, Derek/AAB-5908-2020 + RINALDI, ARIANNA/AGG-5346-2022 + }, times-cited = {4}, + title = {Inferior Olive HCN1 Channels Coordinate Synaptic Integration and Complex + Spike Timing}, + type = {Article}, + unique-id = {WOS:000424981600009}, usage-count-last-180-days = {0}, usage-count-since-2013 = {6}, - journal-iso = {Cell Reports}, - doc-delivery-number = {FW0JV}, + volume = {22}, + web-of-science-categories = {Cell Biology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000424981600009}, - oa = {Green Published, gold}, - da = {2024-02-13} + year = {2018} } -@article{WOS:000388572700024, - author = {Surmeli, Gulsen and Marcu, Daniel Cosmin and McClure, Christina and - Garden, Derek L. F. and Pastoll, Hugh and Nolan, Matthew F.}, - title = {Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep - Layers of the Medial Entorhinal Cortex (vol 88, pg 1040, 2015)}, - journal = {NEURON}, - year = {2016}, - volume = {92}, - number = {4}, - pages = {929}, - month = {NOV 23}, - publisher = {CELL PRESS}, - address = {600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA}, - type = {Correction}, +@article{WOS:000505692200033, + abbr = {NOLAN}, + abstract = {Episodic memory requires different types of information to be bound + together to generate representations of experiences. The lateral + entorhinal cortex (LEC) and hippocampus are required for episodic like + memory in rodents {[}1, 2]. The LEC is critical for integrating spatial + and contextual information about objects {[}236]. Further, LEC neurons + encode objects in the environment and the locations where objects were + previously experienced and generate representations of time during the + encoding and retrieval of episodes {[}7312]. However, it remains unclear + how specific populations of cells within the LEC contribute to the + integration of episodic memory components. Layer 2 (L2) of LEC manifests + early pathology in Alzheimer's disease (AD) and related animal models + {[}13-16]. Projections to the hippocampus from L2 of LEC arise from fan + cells in a superficial sub -layer (L2a) that are immunoreactive for + reelin and project to the dentate gyrus {[}17, 18]. Here, we establish + an approach for selectively targeting fan cells using Siml:Cre mice. + Whereas complete lesions of the LEC were previously found to abolish + associative recognition memory {[}2, 3], we report that, after selective + suppression of synaptic output from fan cells, mice can discriminate + novel object-context configurations but are impaired in recognition of + novel object-place-context associations. Our results suggest that memory + functions are segregated between distinct LEC networks.}, + address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Hugh Robson Bldg,15 George Sq, Edinburgh EH8 9XE, Midlothian, Scotland. + Ainge, JA (Corresponding Author), Univ St Andrews, Sch Psychol \& Neurosci, South St, St Andrews KY16 9JP, Fife, Scotland. + Vandrey, Brianna; Garden, Derek L. F.; McClure, Christina; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Hugh Robson Bldg,15 George Sq, Edinburgh EH8 9XE, Midlothian, Scotland. + Vandrey, Brianna; Ambrozova, Veronika; Ainge, James A., Univ St Andrews, Sch Psychol \& Neurosci, South St, St Andrews KY16 9JP, Fife, Scotland.}, + affiliations = {University of Edinburgh; University of St Andrews}, + author = {Vandrey, Brianna and Garden, Derek L. F. and Ambrozova, Veronika and + McClure, Christina and Nolan, Matthew F. and Ainge, James A.}, + author-email = {matt.nolan@ed.ac.uk + jaa7@st-andrews.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {KA3IK}, + doi = {10.1016/j.cub.2019.11.027}, + eissn = {1879-0445}, + funding-acknowledgement = {Carnegie Trust; Henry Dryerre scholarship from the Royal Society of + Edinburgh; Wellcome Trust {[}200855/Z/16/Z]; BBSRC {[}BB/M025454/1]; + Wellcome Trust {[}200855/Z/16/Z] Funding Source: Wellcome Trust; BBSRC + {[}BB/M025454/1] Funding Source: UKRI}, + funding-text = {This work was supported by a Carnegie Trust Collaborative Research Grant + to J.A. and M.F.N., a Henry Dryerre scholarship from the Royal Society + of Edinburgh to B.V., and grants from Wellcome Trust (200855/Z/16/Z) and + BBSRC (BB/M025454/1) to M.F.N.}, + issn = {0960-9822}, + journal = {CURRENT BIOLOGY}, + journal-iso = {Curr. Biol.}, + keywords-plus = {DENTATE GYRUS; BINDING DEFICITS; OBJECT-CONTEXT; STELLATE CELLS; + NEURONS; PLACE; RECOGNITION; CA3; REPRESENTATION; PARVALBUMIN}, language = {English}, - doi = {10.1016/j.neuron.2016.11.011}, - issn = {0896-6273}, - eissn = {1097-4199}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {mattnolan@ed.ac.uk}, - researcherid-numbers = {Surmeli, Gulsen/AAJ-1906-2020 - Nolan, Matthew F/A-1356-2009 + month = {JAN 6}, + number = {1}, + number-of-cited-references = {59}, + oa = {Green Published, Green Submitted, hybrid}, + orcid-numbers = {Garden, Derek/0000-0003-3336-3791 + Nolan, Matthew F/0000-0003-1062-6501 + Ainge, James A/0000-0002-0007-1533}, + pages = {169+}, + publisher = {CELL PRESS}, + research-areas = {Biochemistry \& Molecular Biology; Life Sciences \& Biomedicine - Other + Topics; Cell Biology}, + researcherid-numbers = {Core, Vector/CAF-4832-2022 Garden, Derek/AAB-5908-2020 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Garden, Derek/0000-0003-3336-3791 - Marcu, Daniel-Cosmin/0000-0002-1006-3094 - SURMELI, GULSEN/0000-0002-3227-0641}, - number-of-cited-references = {1}, - times-cited = {9}, + Nolan, Matthew F/A-1356-2009 + Ainge, James A/D-5831-2012}, + times-cited = {32}, + title = {Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for + Episodic-like Memory}, + type = {Article}, + unique-id = {WOS:000505692200033}, usage-count-last-180-days = {1}, - usage-count-since-2013 = {4}, - journal-iso = {Neuron}, - doc-delivery-number = {ED0ZH}, + usage-count-since-2013 = {7}, + volume = {30}, + web-of-science-categories = {Biochemistry \& Molecular Biology; Biology; Cell Biology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000388572700024}, - oa = {Green Published, hybrid}, - da = {2024-02-13} + year = {2020} } -@article{WOS:000288736500012, - author = {Zonta, Barbara and Desmazieres, Anne and Rinaldi, Arianna and Tait, - Steven and Sherman, Diane L. and Nolan, Matthew F. and Brophy, Peter J.}, - title = {A Critical Role for Neurofascin in Regulating Action Potential - Initiation through Maintenance of the Axon Initial Segment}, - journal = {NEURON}, - year = {2011}, - volume = {69}, - number = {5}, - pages = {945-956}, - month = {MAR 10}, - abstract = {The axon initial segment (AIS) is critical for the initiation and - propagation of action potentials. Assembly of the AIS requires - interactions between scaffolding molecules and voltage-gated sodium - channels, but the molecular mechanisms that stabilize the AIS are poorly - understood. The neuronal isoform of Neurofascin, Nfasc186, clusters - voltage-gated sodium channels at nodes of Ranvier in myelinated nerves: - here, we investigate its role in AIS assembly and stabilization. - Inactivation of the Nfasc gene in cerebellar Purkinje cells of adult - mice causes rapid loss of Nfasc186 from the AIS but not from nodes of - Ranvier. This causes AIS disintegration, impairment of motor learning - and the abolition of the spontaneous tonic discharge typical of Purkinje - cells. Nevertheless, action potentials with a modified waveform can - still be evoked and basic motor abilities remain intact. We propose that - Nfasc186 optimizes communication between mature neurons by anchoring the - key elements of the adult AIS complex.}, - publisher = {CELL PRESS}, - address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, - type = {Article}, +@article{WOS:000519942200001, + abbr = {NOLAN}, + abstract = {Distinctions between cell types underpin organizational principles for + nervous system function. Functional variation also exists between + neurons of the same type. This is exemplified by correspondence between + grid cell spatial scales and the synaptic integrative properties of + stellate cells (SCs) in the medial entorhinal cortex. However, we know + little about how functional variability is structured either within or + between individuals. Using ex-vivo patch-clamp recordings from up to 55 + SCs per mouse, we found that integrative properties vary between mice + and, in contrast to the modularity of grid cell spatial scales, have a + continuous dorsoventral organization. Our results constrain mechanisms + for modular grid firing and provide evidence for inter-animal phenotypic + variability among neurons of the same type. We suggest that neuron type + properties are tuned to circuit-level set points that vary within and + between animals.}, + address = {SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland. + Pastoll, Hugh; Garden, Derek L.; Surmeli, Gulden; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland. + Papastathopoulos, Ioannis, Alan Turing Inst, London, England. + Papastathopoulos, Ioannis, Univ Edinburgh, Maxwell Inst, Sch Math, Edinburgh, Midlothian, Scotland. + Papastathopoulos, Ioannis, Univ Edinburgh, Ctr Stat, Edinburgh, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; Heriot Watt University; University of + Edinburgh; University of Edinburgh}, + article-number = {e52258}, + author = {Pastoll, Hugh and Garden, Derek L. and Papastathopoulos, Ioannis and + Surmeli, Gulden and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {KU8DN}, + doi = {10.7554/eLife.52258}, + funding-acknowledgement = {Biotechnology and Biological Sciences Research Council (BBSRC) + {[}200855/Z/16/Z, BB/1022147/1]; Biotechnology and Biological Sciences + Research Council {[}BB/H020284/1]; Wellcome {[}200855/Z/16/Z]; BBSRC + {[}BB/L010496/1, BB/H020284/1, BB/I022147/1] Funding Source: UKRI; + Wellcome Trust {[}200855/Z/16/Z] Funding Source: Wellcome Trust}, + funding-text = {Biotechnology and Biological Sciences Research Council (BBSRC) + 200855/Z/16/Z Matthew F Nolan; Biotechnology and Biological Sciences + Research Council (BBSRC) BB/1022147/1 Matthew F Nolan; Biotechnology and + Biological Sciences Research Council BB/H020284/1 Matthew F Nolan; + Wellcome 200855/Z/16/Z Matthew F Nolan; The funders had no role in study + design, data collection and interpretation, or the decision to submit + the work for publication.}, + issn = {2050-084X}, + journal = {ELIFE}, + journal-iso = {eLife}, + keywords-plus = {GRID CELLS; HCN1 CHANNELS; LAYER-II; NEURONS; MODEL; DORSAL; THETA; + OSCILLATIONS; FREQUENCY; ORGANIZATION}, language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. - Rinaldi, Arianna; Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. - Zonta, Barbara; Desmazieres, Anne; Tait, Steven; Sherman, Diane L.; Brophy, Peter J., Univ Edinburgh, Ctr Neuroregenerat, Edinburgh EH16 4SB, Midlothian, Scotland.}, - doi = {10.1016/j.neuron.2011.02.021}, - issn = {0896-6273}, - eissn = {1097-4199}, - keywords-plus = {CEREBELLAR PURKINJE NEURONS; CELL-ADHESION MOLECULES; BETA-IV-SPECTRIN; - SODIUM-CHANNEL BETA-1; ANKYRIN-G; PYRAMIDAL NEURONS; NERVOUS-SYSTEM; ION - CHANNELS; NA CHANNELS; L1 FAMILY}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {mattnolan@ed.ac.uk - peter.brophy@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh}, - researcherid-numbers = {RINALDI, ARIANNA/AGG-5346-2022 - Rinaldi, Arianna/F-4713-2018 - Nolan, Matthew F/A-1356-2009 + month = {FEB 13}, + number-of-cited-references = {84}, + oa = {Green Submitted, gold, Green Published}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + SURMELI, GULSEN/0000-0002-3227-0641 + Garden, Derek/0000-0003-3336-3791}, + publisher = {eLIFE SCIENCES PUBL LTD}, + research-areas = {Life Sciences \& Biomedicine - Other Topics}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 }, - orcid-numbers = {RINALDI, ARIANNA/0000-0002-5167-7420 - Rinaldi, Arianna/0000-0002-5167-7420 - Nolan, Matthew F/0000-0003-1062-6501 - Desmazieres, Anne/0000-0001-6542-4566}, - funding-acknowledgement = {Medical Research Council; Wellcome Trust; Marie Curie Excellence Grant; - ARSEP; EU; Medical Research Council {[}G0501216, G0301172] Funding - Source: researchfish; MRC {[}G0501216, G0301172] Funding Source: UKRI}, - funding-text = {We thank Heather Anderson for excellent assistance. We acknowledge - generous gifts of tissue from NrCAM-null mice from Dr Valerie Castellani - (University of Lyon), and these mice were originally generated by Dr - Fritz Rathjen (Max-Delbruck-Centre, Berlin) to whom thanks are due for - tissue used in preliminary experiments. Drs. V. Bennett and M. Rasband - are thanked for generous gifts of antibodies to AnkyrinG and Caspr, - respectively. We gratefully acknowledge the gift of the CreERT2 cassette - from Prof. P. Chambon (IGBMC/GIE-CERBM). This work was supported by the - Medical Research Council, the Wellcome Trust, a Marie Curie Excellence - Grant, ARSEP, and an EU Framework 7 grant to NGIDD.}, - number-of-cited-references = {64}, - times-cited = {112}, + times-cited = {12}, + title = {Inter- and intra-animal variation in the integrative properties of + stellate cells in the medial entorhinal cortex}, + type = {Article}, + unique-id = {WOS:000519942200001}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {12}, - journal-iso = {Neuron}, - doc-delivery-number = {739RU}, - web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000288736500012}, - oa = {hybrid, Green Submitted, Green Published}, - da = {2024-02-13} + usage-count-since-2013 = {6}, + volume = {9}, + web-of-science-categories = {Biology}, + web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)}, + year = {2020} } -@article{WOS:000323427000002, - author = {Thuault, Sebastien J. and Malleret, Gael and Constantinople, Christine - M. and Nicholls, Russell and Chen, Irene and Zhu, Judy and Panteleyev, - Andrey and Vronskaya, Svetlana and Nolan, Matthew F. and Bruno, Randy - and Siegelbaum, Steven A. and Kandel, Eric R.}, - title = {Prefrontal Cortex HCN1 Channels Enable Intrinsic Persistent Neural - Firing and Executive Memory Function}, - journal = {JOURNAL OF NEUROSCIENCE}, - year = {2013}, - volume = {33}, - number = {34}, - pages = {13583-13599}, - month = {AUG 21}, - abstract = {In many cortical neurons, HCN1 channels are the major contributors to - I-h, the hyperpolarization-activated current, which regulates the - intrinsic properties of neurons and shapes their integration of synaptic - inputs, paces rhythmic activity, and regulates synaptic plasticity. - Here, we examine the physiological role of I-h in deep layer pyramidal - neurons in mouse prefrontal cortex (PFC), focusing on persistent - activity, a form of sustained firing thought to be important for the - behavioral function of the PFC during working memory tasks. We find that - HCN1 contributes to the intrinsic persistent firing that is induced by a - brief depolarizing current stimulus in the presence of muscarinic - agonists. Deletion of HCN1 or acute pharmacological blockade of I-h - decreases the fraction of neurons capable of generating persistent - firing. The reduction in persistent firing is caused by the membrane - hyperpolarization that results from the deletion of HCN1 or I-h - blockade, rather than a specific role of the hyperpolarization-activated - current in generating persistent activity. In vivo recordings show that - deletion of HCN1 has no effect on up states, periods of enhanced - synaptic network activity. Parallel behavioral studies demonstrate that - HCN1 contributes to the PFC-dependent resolution of proactive - interference during working memory. These results thus provide genetic - evidence demonstrating the importance of HCN1 to intrinsic persistent - firing and the behavioral output of the PFC. The causal role of - intrinsic persistent firing in PFC-mediated behavior remains an open - question.}, - publisher = {SOC NEUROSCIENCE}, - address = {11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA}, - type = {Article}, +@article{WOS:000568891400011, + abbr = {NOLAN}, + abstract = {Grid and head direction codes represent cognitive spaces for navigation + and memory. Pure grid cells generate grid codes that have been assumed + to be independent of head direction, whereas conjunctive cells generate + grid representations that are tuned to a single head direction. Here, we + demonstrate that pure grid cells also encode head direction, but through + distinct mechanisms. We show that individual firing fields of pure grid + cells are tuned to multiple head directions, with the preferred sets of + directions differing between fields. This local directional modulation + is not predicted by previous continuous attractor or oscillatory + interference models of grid firing but is accounted for by models in + which pure grid cells integrate inputs from co-aligned conjunctive cells + with firing rates that differ between their fields. We suggest that + local directional signals from grid cells may contribute to downstream + computations by decorrelating different points of view from the same + location. Neurons with grid firing fields are thought to play important + roles in spatial cognition. Here, the authors show that in contrast to + assumptions underlying current models and analyses, grid fields are + modulated by local head direction; this suggests different mechanisms + and new roles for grid firing.}, + address = {MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. + Nolan, MF (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh EH8 9XD, Midlothian, Scotland. + Gerlei, Klara; Passlack, Jessica; Hawes, Ian; Vandrey, Brianna; Stevens, Holly; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. + Papastathopoulos, Ioannis, Univ Edinburgh, Sch Math, Maxwell Inst, Edinburgh EH9 3FD, Midlothian, Scotland. + Papastathopoulos, Ioannis, Univ Edinburgh, Ctr Stat, Edinburgh EH9 3FD, Midlothian, Scotland. + Papastathopoulos, Ioannis, Alan Turing Inst, 96 Euston Rd, London NW1 2DB, England. + Nolan, Matthew F., Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh; Heriot Watt + University; University of Edinburgh; University of Edinburgh}, + article-number = {4228}, + author = {Gerlei, Klara and Passlack, Jessica and Hawes, Ian and Vandrey, Brianna + and Stevens, Holly and Papastathopoulos, Ioannis and Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {NN6JC}, + doi = {10.1038/s41467-020-17500-1}, + funding-acknowledgement = {Wellcome Trust {[}200855/Z/16/Z]; BBSRC {[}BB/L010496/1]; Centre for + Statistics at the University of Edinburgh; College of Medicine and + Veterinary Medicine PhD Studentship - Thomas Work Fellowship; Wellcome + Trust Translational Neuroscience PhD programme {[}108890/Z/15/Z]; BBSRC + {[}BB/L010496/1] Funding Source: UKRI; Wellcome Trust {[}200855/Z/16/Z] + Funding Source: Wellcome Trust}, + funding-text = {We thank Gulen Surmeli and Derek Garden for comments on the manuscript; + Emma Wood, Michael Allerhand and members of the Nolan laboratory for + helpful discussions and Elizabeth Allison for assistance with set up of + open field recordings and initial analysis. We thank scidraw.io for the + mouse schematic. This work was supported by grants to M.F.N. from the + Wellcome Trust (200855/Z/16/Z) and the BBSRC (BB/L010496/1); to I.P. and + M.F.N. from the Centre for Statistics at the University of Edinburgh; by + a College of Medicine and Veterinary Medicine PhD Studentship, funded by + the Thomas Work Fellowship, to K.G. and by the Wellcome Trust + (108890/Z/15/Z) Translational Neuroscience PhD programme to I.H. This + work made use of resources provided by the Edinburgh Compute and Data + Facility.}, + issn = {2041-1723}, + journal = {NATURE COMMUNICATIONS}, + journal-iso = {Nat. Commun.}, + keywords-plus = {MEDIAL ENTORHINAL CORTEX; PATH-INTEGRATION; PATTERN SEPARATION; STELLATE + CELLS; MODEL; MAP; OSCILLATIONS; MECHANISMS; NAVIGATION; MEMORY}, language = {English}, - affiliation = {Kandel, ER (Corresponding Author), Columbia Univ, Dept Neurosci, New York, NY 10032 USA. - Thuault, Sebastien J.; Constantinople, Christine M.; Nicholls, Russell; Chen, Irene; Zhu, Judy; Panteleyev, Andrey; Vronskaya, Svetlana; Bruno, Randy; Siegelbaum, Steven A.; Kandel, Eric R., Columbia Univ, Dept Neurosci, New York, NY 10032 USA. - Malleret, Gael, Fac Med Laennec, CNRS, UMR 5167, F-69372 Lyon, France. - Nolan, Matthew F., Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland. - Bruno, Randy; Siegelbaum, Steven A.; Kandel, Eric R., Columbia Univ, Kavli Inst Brain Sci, New York, NY 10032 USA. - Kandel, Eric R., Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA.}, - doi = {10.1523/JNEUROSCI.2427-12.2013}, - issn = {0270-6474}, - keywords-plus = {NEOCORTICAL PYRAMIDAL NEURONS; GENERAL FLUID INTELLIGENCE; - RAT-ASSOCIATION CORTEX; SHORT-TERM-MEMORY; WORKING-MEMORY; IN-VIVO; - ENTORHINAL CORTEX; UNIT-ACTIVITY; NUCLEUS BASALIS; INTEGRATIVE - PROPERTIES}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {sas8@columbia.edu - erk5@columbia.edu}, - affiliations = {Columbia University; Centre National de la Recherche Scientifique - (CNRS); Universite Claude Bernard Lyon 1; University of Edinburgh; - Columbia University; Howard Hughes Medical Institute; Columbia - University}, - researcherid-numbers = {Bruno, Randy M./ABC-2117-2021 - Nolan, Matthew F/A-1356-2009 - Panteleyev, Andrey/AAJ-1353-2020}, - orcid-numbers = {Bruno, Randy M./0000-0002-5122-4632 - Nolan, Matthew F/0000-0003-1062-6501 + month = {AUG 24}, + number = {1}, + number-of-cited-references = {56}, + oa = {gold, Green Published}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Gerlei, Klara/0000-0002-7803-6666 + , Ian/0000-0002-3574-7812 + Papastathopoulos, Ioannis/0000-0002-7498-2540 + Passlack, Jessica/0000-0002-1043-3980}, + publisher = {NATURE PUBLISHING GROUP}, + research-areas = {Science \& Technology - Other Topics}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 }, - funding-acknowledgement = {Howard Hughes Medical Institute from National Institutes of Health - {[}R01 MH045923, MH80745]; National Alliance for Research on - Schizophrenia and Depression Young Investigator Award}, - funding-text = {This work was supported by the Howard Hughes Medical Institute, grants - R01 MH045923 and MH80745 from National Institutes of Health (E.R.K. and - S.A.S.), and a National Alliance for Research on Schizophrenia and - Depression Young Investigator Award (S.J.T.). We are grateful to Bina - Santoro, Eleanor Simpson, Christoph Kellendonk, Pierre Trifilieff, Ilias - Pavlopoulos, Alexei Morozov, Pablo Jercog, Joseph Rayman, Harshad - Vishwasrao, Vivien Chevaleyre, Rebecca Piskorowski, and Alexander - Arguello for technical advice, reagents, and discussions about this - manuscript. We also thank Deqi Yin and Brittany Dubose for expert - technical assistance.}, - number-of-cited-references = {93}, - times-cited = {59}, - usage-count-last-180-days = {0}, - usage-count-since-2013 = {16}, - journal-iso = {J. Neurosci.}, - doc-delivery-number = {205FC}, + times-cited = {17}, + title = {Grid cells are modulated by local head direction}, + type = {Article}, + unique-id = {WOS:000568891400011}, + usage-count-last-180-days = {1}, + usage-count-since-2013 = {15}, + volume = {11}, + web-of-science-categories = {Multidisciplinary Sciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000323427000002}, - oa = {Green Published, hybrid}, - da = {2024-02-13} + year = {2020} } -@article{WOS:000423898500019, - author = {Tennant, Sarah A. and Fischer, Lukas and Garden, Derek L. F. and Gerlei, - Klara Zsofia and Martinez-Gonzalez, Cristina and McClure, Christina and - Wood, Emma R. and Nolan, Matthew F.}, - title = {Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial - Learning}, - journal = {CELL REPORTS}, - year = {2018}, - volume = {22}, - number = {5}, - pages = {1313-1324}, - month = {JAN 30}, - abstract = {Spatial learning requires estimates of location that may be obtained by - path integration or from positional cues. Grid and other spatial firing - patterns of neurons in the superficial medial entorhinal cortex (MEC) - suggest roles in behavioral estimation of location. However, - distinguishing the contributions of path integration and cue-based - signals to spatial behaviors is challenging, and the roles of identified - MEC neurons are unclear. We use virtual reality to dissociate linear - path integration from other strategies for behavioral estimation of - location. We find that mice learn to path integrate using motor-related - self-motion signals, with accuracy that decreases steeply as a function - of distance. We show that inactivation of stellate cells in superficial - MEC impairs spatial learning in virtual reality and in a real world - object location recognition task. Our results quantify contributions of - path integration to behavior and corroborate key predictions of models - in which stellate cells contribute to location estimation.}, - publisher = {CELL PRESS}, - address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, - type = {Article}, +@article{WOS:000710927500041, + abbr = {NOLAN}, + abstract = {Seizures can emerge from multiple or large foci in temporal lobe + epilepsy, complicating focally targeted strategies such as surgical + resection or the modulation of the activity of specific hippocampal + neuronal populations through genetic or optogenetic techniques. Here, we + evaluate a strategy in which optogenetic activation of medial septal + GABAergic neurons, which provide extensive projections throughout the + hippocampus, is used to control seizures. We utilized the chronic + intrahippocampal kainate mouse model of temporal lobe epilepsy, which + results in spontaneous seizures and as is often the case in human + patients, presents with hippocampal sclerosis. Medial septal GABAergic + neuron populations were immunohistochemically labelled and were not + reduced in epileptic conditions. Genetic labelling with mRuby of medial + septal GABAergic neuron synaptic puncta and imaging across the rostral + to caudal extent of the hippocampus, also indicated an unchanged number + of putative synapses in epilepsy. Furthermore, optogenetic stimulation + of medial septal GABAergic neurons consistently modulated oscillations + across multiple hippocampal locations in control and epileptic + conditions. Finally, wireless optogenetic stimulation of medial septal + GABAergic neurons, upon electrographic detection of spontaneous + hippocampal seizures, resulted in reduced seizure durations. We propose + medial septal GABAergic neurons as a novel target for optogenetic + control of seizures in temporal lobe epilepsy.}, + address = {GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND}, + affiliation = {Gonzalez-Sulser, A (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Patrick Wild Ctr, Simons Initiat Developing Brain, Edinburgh, Midlothian, Scotland. + Hristova, Katerina; Martinez-Gonzalez, Cristina; Watson, Thomas C.; Codadu, Neela K.; Kind, Peter C.; Nolan, Matthew F.; Gonzalez-Sulser, Alfredo, Univ Edinburgh, Ctr Discovery Brain Sci, Patrick Wild Ctr, Simons Initiat Developing Brain, Edinburgh, Midlothian, Scotland. + Hristova, Katerina; Martinez-Gonzalez, Cristina; Watson, Thomas C.; Codadu, Neela K.; Kind, Peter C.; Nolan, Matthew F.; Gonzalez-Sulser, Alfredo, Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Midlothian, Scotland. + Hristova, Katerina; Martinez-Gonzalez, Cristina; Watson, Thomas C.; Codadu, Neela K.; Kind, Peter C.; Nolan, Matthew F.; Gonzalez-Sulser, Alfredo, Univ Edinburgh, Patrick Wild Ctr, Edinburgh, Midlothian, Scotland. + Hashemi, Kevan, Open Source Instruments, Watertown, MA USA.}, + affiliations = {University of Edinburgh; University of Edinburgh; University of + Edinburgh}, + author = {Hristova, Katerina and Martinez-Gonzalez, Cristina and Watson, Thomas C. + and Codadu, Neela K. and Hashemi, Kevan and Kind, Peter C. and Nolan, + Matthew F. and Gonzalez-Sulser, Alfredo}, + author-email = {agonzal2@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {WM2NM}, + doi = {10.1093/brain/awab042}, + earlyaccessdate = {MAR 2021}, + eissn = {1460-2156}, + funding-acknowledgement = {Epilepsy Research UK {[}F1603, P1602]; Simons Initiative for the + Developing Brain; Medical Research Council {[}MR/P006213/1]; Wellcome + Trust {[}200855/Z/16/Z]; MRC {[}MR/P006213/1] Funding Source: UKRI; + Wellcome Trust {[}200855/Z/16/Z] Funding Source: Wellcome Trust}, + funding-text = {This work was supported by Epilepsy Research UK F1603 (A.G.S.) and P1602 + (N.K.C.), the Simons Initiative for the Developing Brain (A.G.S., K.H., + C.M.G., T.C.W., N.K.C, P.C.K., M.F.N.), the Medical Research Council + MR/P006213/1 (P.C.K.) and the Wellcome Trust 200855/Z/16/Z (M.F.N.)}, + issn = {0006-8950}, + journal = {BRAIN}, + journal-iso = {Brain}, + keywords = {medial septum GABAergic neurons; temporal lobe epilepsy; network + stimulation; optogenetics; wireless closed-loop intervention}, + keywords-plus = {TEMPORAL-LOBE EPILEPSY; DENTATE GYRUS; HIPPOCAMPAL SCLEROSIS; THETA + OSCILLATIONS; MOUSE MODEL; INTERNEURONS; BRAIN; PROJECTIONS; PATHWAYS; + CELLS}, + language = {English}, + month = {MAY}, + number = {5}, + number-of-cited-references = {82}, + oa = {Green Published, hybrid, Green Accepted}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Kind, Peter/0000-0002-4256-9639 + Martinez-Gonzalez, Cristina/0000-0001-9969-1160 + Gonzalez-Sulser, Alfredo/0000-0003-3494-4029 + Codadu, Neela Krushna/0000-0002-5819-0340}, + pages = {1576-1589}, + publisher = {OXFORD UNIV PRESS}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {Core, Vector/CAF-4832-2022 + Nolan, Matthew F/A-1356-2009 + }, + times-cited = {21}, + title = {Medial septal GABAergic neurons reduce seizure duration upon optogenetic + closed-loop stimulation}, + type = {Article}, + unique-id = {WOS:000710927500041}, + usage-count-last-180-days = {7}, + usage-count-since-2013 = {23}, + volume = {144}, + web-of-science-categories = {Clinical Neurology; Neurosciences}, + web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, + year = {2021} +} + +@article{WOS:000711952200005, + abbr = {NOLAN}, + abstract = {The deep layers of the entorhinal cortex are important for spatial + cognition, as well as memory storage, consolidation and retrieval. A + long-standing hypothesis is that deep-layer neurons relay spatial and + memory-related signals between the hippocampus and telencephalon. We + review the implications of recent circuit-level analyses that suggest + more complex roles. The organization of deep entorhinal layers is + consistent with multi-stage processing by specialized cell populations; + in this framework, hippocampal, neocortical, and subcortical inputs are + integrated to generate representations for use by targets in the + telencephalon and for feedback to the superficial entorhinal cortex and + hippocampus. Addressing individual sublayers of the deep entorhinal + cortex in future experiments and models will be important for + establishing systems-level mechanisms for spatial cognition and episodic + memory.}, + address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Midlothian, Scotland. + Nolan, MF (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Midlothian, Scotland. + Gerlei, Klara Z.; Brown, Christina M.; Surmeli, Gulsen; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Midlothian, Scotland. + Surmeli, Gulsen; Nolan, Matthew F., Univ Edinburgh, Simons Initiat Developing Brain, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh}, + author = {Gerlei, Klara Z. and Brown, Christina M. and Surmeli, Gulsen and Nolan, + Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {WN7MS}, + doi = {10.1016/j.tins.2021.08.003}, + earlyaccessdate = {OCT 2021}, + eissn = {1878-108X}, + funding-acknowledgement = {Simons Initiative for the Developing Brain; Wellcome Trust + {[}200855/Z/16/Z, 211236/Z/18/Z]; EastBio PhD programme; Wellcome Trust + {[}211236/Z/18/Z, 200855/Z/16/Z] Funding Source: Wellcome Trust}, + funding-text = {We thank members of the laboratories of M.F.N. and G.S. for helpful + discussions. This work was supported by the Simons Initiative for the + Developing Brain, by awards from the Wellcome Trust (200855/Z/16/Z to + M.F.N. and 211236/Z/18/Z to G.S.) , and by the EastBio PhD programme (to + C.B.) .}, + issn = {0166-2236}, + journal = {TRENDS IN NEUROSCIENCES}, + journal-iso = {Trends Neurosci.}, + keywords-plus = {COMPLEMENTARY LEARNING-SYSTEMS; LAYER-V NEURONS; PERSISTENT ACTIVITY; + SUPERFICIAL LAYERS; PARAHIPPOCAMPAL REGION; HIPPOCAMPAL-FORMATION; + RIPPLE OSCILLATIONS; CORTICAL-NEURONS; RAT; PROJECTIONS}, + language = {English}, + month = {NOV}, + number = {11}, + number-of-cited-references = {92}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + SURMELI, GULSEN/0000-0002-3227-0641}, + pages = {876-887}, + publisher = {CELL PRESS}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + }, + times-cited = {18}, + title = {Deep entorhinal cortex: from circuit organization to spatial cognition + and memory}, + type = {Review}, + unique-id = {WOS:000711952200005}, + usage-count-last-180-days = {5}, + usage-count-since-2013 = {18}, + volume = {44}, + web-of-science-categories = {Neurosciences}, + web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)}, + year = {2021} +} + +@article{WOS:000733722200008, + abbr = {NOLAN}, + address = {GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND}, + article-number = {e79}, + author = {Hristova, Katerina and Martinez-Gonzalez, Cristina and Watson, Thomas C. + and Codadu, Neela K. and Hashemi, Kevan and Kind, Peter C. and Nolan, + Matthew F. and Gonzalez-Sulser, Alfredo}, + da = {2024-02-13}, + doc-delivery-number = {XT6VH}, + doi = {10.1093/brain/awab212}, + earlyaccessdate = {JUN 2021}, + eissn = {1460-2156}, + issn = {0006-8950}, + journal = {BRAIN}, + journal-iso = {Brain}, + language = {English}, + month = {SEP}, + number = {9}, + number-of-cited-references = {1}, + oa = {Green Published, hybrid}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501}, + publisher = {OXFORD UNIV PRESS}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009}, + times-cited = {1}, + title = {Medial septal GABAergic neurons reduce seizure duration upon optogenetic + closed-loop stimulation (vol 144, pg 1576, 2021)}, + type = {Correction}, + unique-id = {WOS:000733722200008}, + usage-count-last-180-days = {0}, + usage-count-since-2013 = {0}, + volume = {144}, + web-of-science-categories = {Clinical Neurology; Neurosciences}, + web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, + year = {2021} +} + +@article{WOS:000850307700001, + abbr = {NOLAN}, + abstract = {Establishing the biological basis of cognition and its disorders will + require high precision spatiotemporal measurements of neural activity. + Recently developed genetically encoded voltage indicators (GEVIs) report + both spiking and subthreshold activity of identified neurons. However, + maximally capitalizing on the potential of GEVIs will require imaging at + millisecond time scales, which remains challenging with standard camera + systems. Here, application of single photon avalanche diode (SPAD) + sensors is reported to image neural activity at kilohertz frame rates. + SPADs are electronic devices that when activated by a single photon + cause an avalanche of electrons and a large electric current. An array + of SPAD sensors is used to image individual neurons expressing the GEVI + Voltron-JF525-HTL. It is shown that subthreshold and spiking activity + can be resolved with shot noise limited signals at frame rates of up to + 10 kHz. SPAD imaging is able to reveal millisecond scale synchronization + of neural activity in an ex vivo seizure model. SPAD sensors may have + widespread applications for investigation of millisecond timescale + neural dynamics.}, + address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. + Gyongy, I (Corresponding Author), Univ Edinburgh, Sch Engn, Inst Integrated Micro \& Nano Syst, Edinburgh EH9 3JL, Midlothian, Scotland. + Nolan, MF (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh EH8 9XD, Midlothian, Scotland. + Tian, Tian; Yuan, Yifang; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. + Mitra, Srinjoy; Gyongy, Istvan, Univ Edinburgh, Sch Engn, Inst Integrated Micro \& Nano Syst, Edinburgh EH9 3JL, Midlothian, Scotland. + Nolan, Matthew F., Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh EH8 9XD, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh; University of + Edinburgh}, + article-number = {2203018}, + author = {Tian, Tian and Yuan, Yifang and Mitra, Srinjoy and Gyongy, Istvan and + Nolan, Matthew F.}, + author-email = {igyongy2@exseed.ed.ac.uk + mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {5W8UC}, + doi = {10.1002/advs.202203018}, + earlyaccessdate = {SEP 2022}, + eissn = {2198-3844}, + funding-acknowledgement = {Wellcome Trust {[}IS3-R2.36, 200855/Z/16/Z]; BBSRC EastBio doctoral + training programme; EPSRC {[}EP/S001638/1]; Wellcome Trust + {[}200855/Z/16/Z] Funding Source: Wellcome Trust}, + funding-text = {The authors thank Robert Henderson and Ian Duguid for helpful + discussions and support. The project was supported by funding from the + Wellcome Trust (ISSF3 award IS3-R2.36 to IG and MFN, and Investigator + Award 200855/Z/16/Z to MFN), the BBSRC EastBio doctoral training + programme, and EPSRC (EP/S001638/1). For the purpose of open access, the + author has applied a CC by public copyright license to any Author + Accepted Manuscript version arising from this submission.}, + journal = {ADVANCED SCIENCE}, + journal-iso = {Adv. Sci.}, + keywords = {genetically encoded voltage indicators (GEVIs); kilohertz frame rate; + neural activity; shot noise; single photon avalanche diodes (SPADs); + temporal binning; voltage imaging}, + language = {English}, + month = {NOV}, + number = {31}, + number-of-cited-references = {27}, + oa = {Green Published, Green Submitted, gold}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Gyongy, Istvan/0000-0003-3931-7972}, + publisher = {WILEY}, + research-areas = {Chemistry; Science \& Technology - Other Topics; Materials Science}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + Gyongy, Istvan/GLR-3372-2022 + }, + times-cited = {3}, + title = {Single Photon Kilohertz Frame Rate Imaging of Neural Activity}, + type = {Article}, + unique-id = {WOS:000850307700001}, + usage-count-last-180-days = {2}, + usage-count-since-2013 = {18}, + volume = {9}, + web-of-science-categories = {Chemistry, Multidisciplinary; Nanoscience \& Nanotechnology; Materials + Science, Multidisciplinary}, + web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, + year = {2022} +} + +@article{WOS:000878031400006, + abbr = {NOLAN}, + abstract = {Neurons in the retrohippocampal cortices play crucial roles in spatial + memory. Many retrohippocampal neu-rons have firing fields that are + selectively active at specific locations, with memory for rewarded + locations associated with reorganization of these firing fields. Whether + this is the sole strategy for representing spatial memories is unclear. + Here, we demonstrate that during a spatial memory task retrohippocampal + neurons encode location through ramping activity that extends across + segments of a linear track approaching and following a reward, with the + rewarded location represented by offsets or switches in the slope of the + ramping activity. Ramping representations could be maintained + independently of trial outcome and cues marking the reward location, + indicating that they result from recall of the track structure. When + recorded in an open arena, neurons that generated ramping activity + during the spatial memory task were more numerous than grid or border + cells, with a majority showing spatial firing that did not meet criteria + for classification as grid or border representations. Encoding of + rewarded locations through offsets and switches in the slope of ramping + activ-ity also emerged in recurrent neural network models trained to + solve a similar spatial memory task. Impaired performance of model + networks following disruption of outputs from ramping neurons is + consistent with this coding strategy supporting navigation to recalled + locations of behavioral significance. Our results suggest that encoding + of learned spaces by retrohippocampal networks employs both discrete + firing fields and continuous ramping representations. We hypothesize + that retrohippocampal ramping activity mediates readout of learned + models for goal-directed navigation.}, + address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Scotland. + Nolan, MF (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Scotland. + Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Stat, Edinburgh, Scotland. + Tennant, Sarah A.; Clark, Harry; Hawes, Ian; Tam, Wing Kin; Hua, Junji; Yang, Wannan; Gerlei, Klara Z.; Wood, Emma R.; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Scotland. + Tam, Wing Kin; Wood, Emma R.; Nolan, Matthew F., Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Scotland. + Nolan, Matthew F., Univ Edinburgh, Ctr Stat, Edinburgh, Scotland. + Yang, Wannan, NYU, Ctr Neural Sci, New York, NY USA.}, + affiliations = {University of Edinburgh; University of Edinburgh; University of + Edinburgh; New York University}, + author = {Tennant, Sarah A. and Clark, Harry and Hawes, Ian and Tam, Wing Kin and + Hua, Junji and Yang, Wannan and Gerlei, Klara Z. and Wood, Emma R. and + Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {5W6OP}, + doi = {10.1016/j.cub.2022.08.050}, + earlyaccessdate = {OCT 2022}, + eissn = {1879-0445}, + funding-acknowledgement = {Wellcome Trust {[}108890/Z/15/Z, 200855/Z/16/Z]; BBSRC {[}BB/L010496/1]; + Simons Initiative for the Developing Brain; College of Medicine and + Veterinary Medicine PhD Studentship - Thomas Work Fellowship; Medical + Research Council Precision Medicine PhD programme; Wellcome Trust + {[}200855/Z/16/Z] Funding Source: Wellcome Trust}, + funding-text = {We thank Richard Morris for feedback on an earlier version of the + manuscript, Robert Wallace for assistance with micro-CT imaging, Holly + Stevens for technical assistance, and Gulsxen Surmeli, Ian Duguid, and + members of the Surmeli, Duguid, and Nolan labs for helpful discussions. + This work was supported by grants to M.F.N. from the Wellcome Trust + (200855/Z/16/Z), the BBSRC (BB/L010496/1), and the Simons Initiative for + the Developing Brain; by a College of Medicine and Veterinary Medicine + PhD Studentship, funded by the Thomas Work Fellowship, to K.Z.G.; by the + Wellcome Trust (108890/Z/15/Z) Translational Neuroscience PhD programme + to I.H.; and by the Medical Research Council Precision Medicine PhD + programme to H.C. This work made use of resources provided by the + Edinburgh Compute and Data Facility. For the purpose of open access, the + author has applied a CC BY public copyright license to any Author + Accepted Manuscript version arising from this submission.}, + issn = {0960-9822}, + journal = {CURRENT BIOLOGY}, + journal-iso = {Curr. Biol.}, + keywords-plus = {ENTORHINAL CORTEX; VENTRAL STRIATUM; SPEED CELLS; GRID CELLS; GAMMA + OSCILLATIONS; PLACE CELLS; HIPPOCAMPUS; NAVIGATION; MAP; INFORMATION}, + language = {English}, + month = {OCT 24}, + number = {20}, + number-of-cited-references = {87}, + oa = {Green Accepted, Green Published, hybrid}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501}, + pages = {4451+}, + publisher = {CELL PRESS}, + research-areas = {Biochemistry \& Molecular Biology; Life Sciences \& Biomedicine - Other + Topics; Cell Biology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009}, + times-cited = {0}, + title = {Spatial representation by ramping activity of neurons in the + retrohippocampal cortex}, + type = {Article}, + unique-id = {WOS:000878031400006}, + usage-count-last-180-days = {0}, + usage-count-since-2013 = {8}, + volume = {32}, + web-of-science-categories = {Biochemistry \& Molecular Biology; Biology; Cell Biology}, + web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, + year = {2022} +} + +@article{WOS:000934319900001, + abbr = {NOLAN}, + abstract = {Standard models for spatial and episodic memory suggest that the lateral + entorhinal cortex (LEC) and medial entorhinal cortex (MEC) send parallel + independent inputs to the hippocampus, each carrying different types of + information. Here, we evaluate the possibility that information is + integrated between divisions of the entorhinal cortex prior to reaching + the hippocampus. We demonstrate that, in mice, fan cells in layer 2 (L2) + of LEC that receive neocortical inputs, and that project to the + hippocampal dentate gyrus, also send axon collaterals to layer 1 (L1) of + the MEC. Activation of inputs from fan cells evokes monosynaptic + glutamatergic excitation of stellate and pyramidal cells in L2 of the + MEC, typically followed by inhibition that contains fast and slow + components mediated by GABA(A) and GABA(B) receptors, respectively. + Inputs from fan cells also directly activate interneurons in L1 and L2 + of MEC, with synaptic connections from L1 interneurons accounting for + slow feedforward inhibition of L2 principal cell populations. The + relative strength of excitation and inhibition following fan cell + activation differs substantially between neurons and is largely + independent of anatomical location. Our results demonstrate that the + LEC, in addition to directly influencing the hippocampus, can activate + or inhibit major hippocampal inputs arising from the MEC. Thus, local + circuits in the superficial MEC may combine spatial information with + sensory and higher order signals from the LEC, providing a substrate for + integration of `what' and `where' components of episodic memories.}, + address = {SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND}, + affiliation = {Vandrey, B; Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Scotland. + Nolan, MF (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Scotland. + Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Stat, Edinburgh, Scotland. + Vandrey, Brianna; Armstrong, Jack; Brown, Christina M.; Garden, Derek L. F.; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Scotland. + Nolan, Matthew F., Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Scotland. + Nolan, Matthew F., Univ Edinburgh, Ctr Stat, Edinburgh, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh; University of + Edinburgh}, + article-number = {e83008}, + author = {Vandrey, Brianna and Armstrong, Jack and Brown, Christina M. and Garden, + Derek L. F. and Nolan, Matthew F.}, + author-email = {brianna.vandrey@ed.ac.uk + mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {9A8SC}, + doi = {10.7554/eLife.83008}, + funding-acknowledgement = {Wellcome Trust {[}200855/Z/16/Z]; BBSRC {[}BB/V010107/1]; Wellcome Trust + {[}200855/Z/16/Z] Funding Source: Wellcome Trust}, + funding-text = {The funders had no role in study design, data collection and + interpretation, or the decision to submit the work for publication. For + the purpose of Open Access, the authors have applied a CC BY public + copyright license to any Author Accepted Manuscript version arising from + this submission.}, + issn = {2050-084X}, + journal = {ELIFE}, + journal-iso = {eLife}, + keywords = {memory; neural circuit; hippocampal formation; optogenetics; Mouse}, + keywords-plus = {TOPOGRAPHIC ORGANIZATION; HIPPOCAMPAL-FORMATION; STELLATE CELLS; + PARAHIPPOCAMPAL REGION; PERIRHINAL CORTEX; RETROHIPPOCAMPAL REGION; + EFFERENT CONNECTIONS; POSTRHINAL CORTICES; ASSOCIATION CORTEX; PYRAMIDAL + NEURONS}, language = {English}, - affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland. - Tennant, Sarah A.; Fischer, Lukas; Garden, Derek L. F.; Gerlei, Klara Zsofia; Martinez-Gonzalez, Cristina; McClure, Christina; Wood, Emma R.; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland.}, - doi = {10.1016/j.celrep.2018.01.005}, - issn = {2211-1247}, - keywords-plus = {GRID CELLS; PATH-INTEGRATION; OCEAN CELLS; INPUT; PLACE; MODEL; - REPRESENTATION; CONTRIBUTE; NAVIGATION; CIRCUITRY}, - research-areas = {Cell Biology}, - web-of-science-categories = {Cell Biology}, - author-email = {mattnolan@ed.ac.uk}, - affiliations = {University of Edinburgh}, - researcherid-numbers = {Garden, Derek/AAB-5908-2020 - Nolan, Matthew F/A-1356-2009 + month = {DEC 23}, + number-of-cited-references = {103}, + oa = {Green Submitted, Green Published, gold}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Garden, Derek/0000-0003-3336-3791}, + publisher = {eLIFE SCIENCES PUBL LTD}, + research-areas = {Life Sciences \& Biomedicine - Other Topics}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 }, - orcid-numbers = {Garden, Derek/0000-0003-3336-3791 - Nolan, Matthew F/0000-0003-1062-6501 - Martinez-Gonzalez, Cristina/0000-0001-9969-1160}, - funding-acknowledgement = {BBSRC {[}BB/L010496/1, BB/M010996/1]; Human Frontiers Science Program - {[}RGP0062/2014]; Wellcome Trust {[}200855/Z/16/Z, WT093295MA]; Wellcome - Trust {[}200855/Z/16/Z] Funding Source: Wellcome Trust; BBSRC - {[}BB/L010496/1, BB/H020284/1] Funding Source: UKRI; Biotechnology and - Biological Sciences Research Council {[}BB/H020284/1, 1312826, 1068019, - BB/L010496/1] Funding Source: researchfish; Wellcome Trust - {[}200855/Z/16/Z] Funding Source: researchfish}, - funding-text = {We thank Ian Duguid for advice in establishing head fixation and - treadmill technologies, Gulsen Surmeli for assistance in targeting of - L2SCs, and Jessica Menzies and Michelle Haglund for collecting the - object recognition and object location data. This work was supported by - the BBSRC (BB/L010496/1 and a BBSRC Eastbio studentship {[}grant - BB/M010996/1]), the Human Frontiers Science Program (RGP0062/2014), and - the Wellcome Trust (200855/Z/16/Z and WT093295MA). The funders had no - role in study design, data collection and analysis, decision to publish, - or preparation of the manuscript.}, - number-of-cited-references = {62}, - times-cited = {40}, - usage-count-last-180-days = {2}, - usage-count-since-2013 = {14}, - journal-iso = {Cell Reports}, - doc-delivery-number = {FU5MV}, - web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000423898500019}, - oa = {Green Published, gold}, - da = {2024-02-13} -} - -@article{WOS:000733722200008, - author = {Hristova, Katerina and Martinez-Gonzalez, Cristina and Watson, Thomas C. - and Codadu, Neela K. and Hashemi, Kevan and Kind, Peter C. and Nolan, - Matthew F. and Gonzalez-Sulser, Alfredo}, - title = {Medial septal GABAergic neurons reduce seizure duration upon optogenetic - closed-loop stimulation (vol 144, pg 1576, 2021)}, - journal = {BRAIN}, - year = {2021}, - volume = {144}, - number = {9}, - month = {SEP}, - publisher = {OXFORD UNIV PRESS}, - address = {GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND}, - type = {Correction}, - language = {English}, - doi = {10.1093/brain/awab212}, - earlyaccessdate = {JUN 2021}, - article-number = {e79}, - issn = {0006-8950}, - eissn = {1460-2156}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Clinical Neurology; Neurosciences}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009}, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501}, - number-of-cited-references = {1}, - times-cited = {1}, + times-cited = {2}, + title = {Fan cells in lateral entorhinal cortex directly influence medial + entorhinal cortex through synaptic connections in layer 1}, + type = {Article}, + unique-id = {WOS:000934319900001}, usage-count-last-180-days = {0}, - usage-count-since-2013 = {0}, - journal-iso = {Brain}, - doc-delivery-number = {XT6VH}, + usage-count-since-2013 = {5}, + volume = {11}, + web-of-science-categories = {Biology}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000733722200008}, - oa = {Green Published, hybrid}, - da = {2024-02-13} + year = {2022} } @article{WOS:000942420800001, - author = {Louros, Susana R. and Seo, Sang S. and Maio, Beatriz and - Martinez-Gonzalez, Cristina and Gonzalez-Lozano, Miguel A. and Muscas, - Melania and Verity, Nick C. and Wills, Jimi C. and Li, Ka Wan and Nolan, - Matthew F. and Osterweil, Emily K.}, - title = {Excessive proteostasis contributes to pathology in fragile X syndrome}, - journal = {NEURON}, - year = {2023}, - volume = {111}, - number = {4}, - pages = {508+}, - month = {FEB 15}, + abbr = {NOLAN}, abstract = {In fragile X syndrome (FX), the leading monogenic cause of autism, excessive neuronal protein synthesis is a core pathophysiology; however, an overall increase in protein expression is not observed. Here, we @@ -2891,36 +2815,25 @@ @article{WOS:000942420800001 specifically in the IC. Together, these results identify excessive activation of the UPS pathway in Fmr1-/y neurons as a contributor to multiple phenotypes that can be targeted for therapeutic intervention.}, - publisher = {CELL PRESS}, address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, - type = {Article}, - language = {English}, affiliation = {Osterweil, EK (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Scotland. Osterweil, EK (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Scotland. Louros, Susana R.; Seo, Sang S.; Maio, Beatriz; Martinez-Gonzalez, Cristina; Muscas, Melania; Verity, Nick C.; Nolan, Matthew F.; Osterweil, Emily K., Univ Edinburgh, Ctr Discovery Brain Sci, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Scotland. Louros, Susana R.; Seo, Sang S.; Maio, Beatriz; Martinez-Gonzalez, Cristina; Muscas, Melania; Verity, Nick C.; Nolan, Matthew F.; Osterweil, Emily K., Univ Edinburgh, Simons Initiat Developing Brain, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Scotland. Gonzalez-Lozano, Miguel A.; Li, Ka Wan, Vrije Univ Amsterdam, Ctr Neurogenom \& Cognit Res, Dept Mol \& Cellular Neurobiol, Amsterdam, Netherlands. Wills, Jimi C., Univ Edinburgh, Inst Genet \& Canc, CRUK Edinburgh Ctr, Edinburgh, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh; Vrije Universiteit + Amsterdam; University of Edinburgh}, + author = {Louros, Susana R. and Seo, Sang S. and Maio, Beatriz and + Martinez-Gonzalez, Cristina and Gonzalez-Lozano, Miguel A. and Muscas, + Melania and Verity, Nick C. and Wills, Jimi C. and Li, Ka Wan and Nolan, + Matthew F. and Osterweil, Emily K.}, + author-email = {Emily.osterweil@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {9M7QZ}, doi = {10.1016/j.neuron.2022.11.012}, earlyaccessdate = {FEB 2023}, - issn = {0896-6273}, eissn = {1097-4199}, - keywords-plus = {MENTAL-RETARDATION PROTEIN; MOUSE MODEL; MESSENGER-RNAS; PROTEASOME - ACTIVITY; UBIQUITIN LIGASES; GENE FMR-1; TRANSLATION; INHIBITION; - IDENTIFICATION; DEGRADATION}, - research-areas = {Neurosciences \& Neurology}, - web-of-science-categories = {Neurosciences}, - author-email = {Emily.osterweil@ed.ac.uk}, - affiliations = {University of Edinburgh; University of Edinburgh; Vrije Universiteit - Amsterdam; University of Edinburgh}, - researcherid-numbers = {Nolan, Matthew F/A-1356-2009 - }, - orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 - Martinez-Gonzalez, Cristina/0000-0001-9969-1160 - Maio, Beatriz/0000-0003-4258-9354 - Osterweil, Emily/0000-0003-0582-2284 - Louros, Susana/0000-0002-1012-0386 - li, ka wan/0000-0001-6983-5055}, funding-acknowledgement = {Wellcome Trust {[}104116/Z/14/Z, 219556/Z/19/Z]; Medical Research Council {[}MR/S026312/1]; Simons Initiative for the Developing Brain; ONO Pharmaceuticals; Wellcome Trust {[}104116/Z/14/Z, 219556/Z/19/Z] @@ -2932,14 +2845,141 @@ @ed.ac.uk Medical Research Council (MR/S026312/1) , Simons Initiative for the Developing Brain (SIDB) , and ONO Pharmaceuticals. We thank the IMPACT facility at the University of Edinburgh for imaging resources.}, + issn = {0896-6273}, + journal = {NEURON}, + journal-iso = {Neuron}, + keywords-plus = {MENTAL-RETARDATION PROTEIN; MOUSE MODEL; MESSENGER-RNAS; PROTEASOME + ACTIVITY; UBIQUITIN LIGASES; GENE FMR-1; TRANSLATION; INHIBITION; + IDENTIFICATION; DEGRADATION}, + language = {English}, + month = {FEB 15}, + number = {4}, number-of-cited-references = {111}, + oa = {Green Accepted, Green Published, hybrid}, + orcid-numbers = {Nolan, Matthew F/0000-0003-1062-6501 + Martinez-Gonzalez, Cristina/0000-0001-9969-1160 + Maio, Beatriz/0000-0003-4258-9354 + Osterweil, Emily/0000-0003-0582-2284 + Louros, Susana/0000-0002-1012-0386 + li, ka wan/0000-0001-6983-5055}, + pages = {508+}, + publisher = {CELL PRESS}, + research-areas = {Neurosciences \& Neurology}, + researcherid-numbers = {Nolan, Matthew F/A-1356-2009 + }, times-cited = {3}, + title = {Excessive proteostasis contributes to pathology in fragile X syndrome}, + type = {Article}, + unique-id = {WOS:000942420800001}, usage-count-last-180-days = {0}, usage-count-since-2013 = {2}, - journal-iso = {Neuron}, - doc-delivery-number = {9M7QZ}, + volume = {111}, + web-of-science-categories = {Neurosciences}, web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, - unique-id = {WOS:000942420800001}, - oa = {Green Accepted, Green Published, hybrid}, - da = {2024-02-13} + year = {2023} +} + +@inproceedings{WOS:000946638602032, + abbr = {NOLAN}, + abstract = {Accurate decoding of neural signals often requires assigning + extracellular waveforms acquired on the same electrode to their + originating neurons, a process known as spike sorting. While many + offline sorters are available, accurate online sorting of spikes with + many channels is still a challenging problem. Existing online sorters + either use simple algorithms with low accuracy, can only process a + handful of channels, or depend on a complex runtime environment that is + difficult to set up. We have developed a state-of-the-art online spike + sorting platform in Python that enables large-scale, fully automatic + real-time spike sorting and decoding on hundreds of channels. Our system + is cross-platform and works seamlessly with the Open Ephys suite of + open-source hardware and software widely used in many neuroscience + laboratories worldwide. It also comes with a user-friendly graphical + user interface to monitor the cluster quality, spike waveforms and + neuronal firing rate. Our platform has comparable accuracy to offline + sorters and can achieve an end-to-end sorting latency of around 160 ms + for 128-channel signals. It will be useful for research in fundamental + neuroscience, closed-loop feedback neuromodulation and brain-computer + interfaces.}, + address = {345 E 47TH ST, NEW YORK, NY 10017 USA}, + affiliation = {Tam, WK (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland. + Tam, WK (Corresponding Author), Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Midlothian, Scotland. + Tam, Wing-Kin; Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland. + Tam, Wing-Kin, Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh, Midlothian, Scotland.}, + affiliations = {University of Edinburgh; University of Edinburgh}, + author = {Tam, Wing-Kin and Nolan, Matthew F.}, + author-email = {wtam2@ed.ac.uk + mattnolan@ed.ac.uk}, + book-group-author = {IEEE}, + booktitle = {2022 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS (ISCAS 22)}, + da = {2024-02-13}, + doc-delivery-number = {BU8EO}, + doi = {10.1109/ISCAS48785.2022.9937512}, + funding-acknowledgement = {Simons Initiative for the Developing Brain}, + funding-text = {This study is supported by the Simons Initiative for the Developing + Brain.}, + isbn = {978-1-6654-8485-5}, + issn = {0271-4302}, + keywords = {spike sorting; neural signal processing; braincomputer interface}, + language = {English}, + note = {IEEE International Symposium on Circuits and Systems (ISCAS), Austin, + TX, MAY 28-JUN 01, 2022}, + number-of-cited-references = {17}, + oa = {Green Submitted}, + organization = {IEEE; Samsung; Synopsys; Silicon Labs; Mediatek; Cadence; Intel; + Qualcomm; IEEE Circuits \& Syst Soc}, + pages = {1943-1947}, + publisher = {IEEE}, + research-areas = {Engineering}, + series = {IEEE International Symposium on Circuits and Systems}, + times-cited = {0}, + title = {pyNeurode: a real-time neural signal processing framework}, + type = {Proceedings Paper}, + unique-id = {WOS:000946638602032}, + usage-count-last-180-days = {0}, + usage-count-since-2013 = {0}, + web-of-science-categories = {Engineering, Electrical \& Electronic}, + web-of-science-index = {Conference Proceedings Citation Index - Science (CPCI-S)}, + year = {2022} +} + +@article{WOS:001110181200001, + abbr = {NOLAN}, + abstract = {Memory consolidation involves interactions between the hippocampus and + other cortical areas. A new study identifies neurons in the medial + entorhinal cortex that over learning increase their coordination with + hippocampal replay events, suggesting a route for consolidation of + spatial memories.}, + address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA}, + affiliation = {Nolan, MF (Corresponding Author), Univ Edinburgh, Ctr Discovery Brain Sci, Simons Initiat Developing Brain, Hugh Robson Bldg, Edinburgh EH8 9XD, Scotland. + Nolan, Matthew F., Univ Edinburgh, Ctr Discovery Brain Sci, Simons Initiat Developing Brain, Hugh Robson Bldg, Edinburgh EH8 9XD, Scotland.}, + affiliations = {University of Edinburgh}, + author = {Nolan, Matthew F.}, + author-email = {mattnolan@ed.ac.uk}, + da = {2024-02-13}, + doc-delivery-number = {Z2BJ6}, + doi = {10.1016/j.cub.2023.09.072}, + earlyaccessdate = {NOV 2023}, + eissn = {1879-0445}, + issn = {0960-9822}, + journal = {CURRENT BIOLOGY}, + journal-iso = {Curr. Biol.}, + keywords-plus = {SHARP WAVE-RIPPLE; HIPPOCAMPAL; REPLAY; LAYERS; OSCILLATIONS; NEURONS}, + language = {English}, + month = {NOV 6}, + number = {21}, + number-of-cited-references = {19}, + pages = {R1160-R1162}, + publisher = {CELL PRESS}, + research-areas = {Biochemistry \& Molecular Biology; Life Sciences \& Biomedicine - Other + Topics; Cell Biology}, + times-cited = {0}, + title = {Memory consolidation: Building influence over the entorhinal cortex}, + type = {Editorial Material}, + unique-id = {WOS:001110181200001}, + usage-count-last-180-days = {4}, + usage-count-since-2013 = {4}, + volume = {33}, + web-of-science-categories = {Biochemistry \& Molecular Biology; Biology; Cell Biology}, + web-of-science-index = {Science Citation Index Expanded (SCI-EXPANDED)}, + year = {2023} }